Sample records for 4-substituted pent-4-enylamines scope

  1. 40 CFR 721.10043 - Dineopentyl-4-substituted phthalate (generic).


    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Dineopentyl-4-substituted phthalate... Specific Chemical Substances § 721.10043 Dineopentyl-4-substituted phthalate (generic). (a) Chemical... as dineopentyl-4-substituted phthalate (PMN P-02-697) is subject to reporting under this section...

  2. The synthesis of some unsaturated 4-substituted-g-lactones



    Full Text Available The synthesis of conjugated and nonconjugated unsaturated 4-substituted lactones of type 1 and 2 are described. The type 1 lactone was prepared by a two step procedure employing Bredereck's reagent. The type 2 lactone was synthesised by combining the Claisen-Ireland rearrangement and selenolactonisation.

  3. Dihydroxylation of 4-substituted 1,2-dioxines

    Robinson, Tony V; Pedersen, Daniel Sejer; Taylor, Dennis K;


    The synthesis of 2-C-branched erythritol derivatives, including the plant sugar (+/-)-2-C-methylerythritol 2, was achieved through a dihydroxylation/reduction sequence on a series of 4-substituted 1,2-dioxines 3. The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to...... optically enriched dihydroxy 1,2-dioxanes 4. The synthesized 1,2-dioxanes were converted to other erythro sugar analogues and tetrahydrofurans through controlled cleavage of the endoperoxide linkage....

  4. Reactivity and Regioselectivity in the Heck Reaction - A Hammett Study of 4-Substituted Styrenes

    Fristrup, Peter; Le Quement, Sebastian; Tanner, David Ackland; Norrby, Per-Ola


    The regioselectivity in the cationic Heck reaction of 4-substituted styrenes was addressed by a Hammett study. In this branching reaction, plots based on the substrate reactivity did not give meaningful data, whereas the product distribution was variable due to differing preferences for further s...

  5. 4-Substituted anilinomethylpropionate: New and efficient corrosion inhibitors for mild steel in hydrochloric acid solution

    4-substituted anilinomethylpropionate namely 3-anilinomethylpropionate (Inh-1), 3-(4-methylanilino)methylpropionate (Inh-2) and 3-(4-chloroanilino) methylpropionate (Inh-3) were synthesized and investigated as corrosion inhibitors of mild steel in 1 N HCl solution using weight loss, polarization resistance, Tafel polarization and electrochemical Impedance spectroscopy techniques. The inhibition efficiency of the synthesized inhibitors followed the order Inh3 > Inh2 > Inh1. The inhibiting action of the all inhibitors was found to depend on electronic nature of functional groups present in inhibitors. Potentiodynamic polarizations suggest that all inhibitors are mixed type in nature. Electrochemical impedance spectroscopy was also used to investigate the mechanism of corrosion inhibition.

  6. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones

    Aurea Echevarria


    Full Text Available We present an efficient procedure for the synthesis of thirty-six N1,N4-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide intermediates with aldehydes in the presence of glacial acetic acid in ethanol and under solvent free conditions. Overall reaction times (20–40 min when ethanol as solvent, and 3 min under solvent free conditions were much shorter than with the traditional procedure (480 min; satisfactory yields and high-purity compounds were obtained. The thiosemicarbazide intermediates were obtained from alkyl or aryl isothiocyanates and hydrazine hydrate or phenyl hydrazine by stirring at room temperature for 60 min or by microwave irradiation for 30 min, with lower yields for the latter. The preliminary in vitro antifungal activity of thiosemicarbazones was evaluated against Aspergillus parasiticus and Candida albicans.

  7. Combustion synthesis and characterization of Sn4+ substituted nanocrystalline NiFe2O4

    A series of Sn4+ substituted NiFe2O4 with general formula Ni1-xSn xFe2O4 (x = 0.0, 0.2, 0.4, 0.6, and 0.8) has been prepared by novel combustion synthetic method. The prepared compounds have been sintered at 1000 deg. C and evaluated for their structural and electrical properties. XRD studies reveal the synthesized compounds are nanocrystalline size with cubic structure. The Fourier transform infrared (FT-IR) spectra show the characteristic features of the synthesized ferrite compounds. The UV-vis spectra reveal the optical band gap of the synthesized compounds. The dc electrical conductivity of the compounds found to increase with increasing measuring temperature. A maximum dc electrical conductivity of 6.0 S cm-1 was obtained at a measuring temperature of 1000 deg. C in the composition of x = 0.8, for which the activation energy for conduction is found to be minimum

  8. 40 CFR 721.267 - N-[2-[(substituted dinitrophenyl)azo]diallylamino-4- substituted phenyl] acetamide (generic name).


    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false N- diallylamino-4- substituted phenyl] acetamide (generic name). 721.267 Section 721.267 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  9. Alpha-Thioalkylation of Zinc Dienolates to 4-Substituted 1-tert-Butoxy-7a-methyl-hexahydroinden-5-ones

    Groth, Ulrich; Köhler, Thomas; Taapken, Thomas


    α-Alkylation of the α,β-unsaturated ketone 1 at C-4 has been achieved by thioalkylation of the corresponding zinc dienolate with α-chlorosulfides of type 2. The desulfurization of the β-(phenylthio) ketones 4 leads directly to the 4-substituted hexahydroinden-5-ones 5.

  10. Development of one pot three component synthesis of 1,4-substituted, 1,2,3-triazoles, employing green catalyst

    Y. L. N arasimha Murthy


    Full Text Available An efficient and eco-friendly protocol for the synthesis of 1,4-substituted-1H-1,2,3-triazoles was achieved employing D-glucosamine as a green ligand with CuI as catalyst. An advantage, of high water solubility, of the ligand facilitates easy catalyst removal. All the products were formed in good yields and were characterized by advanced spectral data.

  11. A microwave approach to the synthesis of certain 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones

    Marinković Aleksandar


    Full Text Available A study of the synthesis of 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones from 2-cyano-3-phenylsubstituted acrylates and acetophenone is presented. 2-Pyridones were obtained using conventional as well as microwave synthesis using solvent and solvent free reactions in domestic and lab microwave ovens. The structure of the obtained pyridones was confirmed by m.p., FT-IR, NMR and UV data. [Projekat Ministarstva nauke Republike Srbije, br. 172013

  12. Planar geometry of 4-substituted-2,2'-bipyridines synthesized by Sonogashira and Suzuki cross-coupling reactions

    Luong Thi, T. T., E-mail:; Nguyen Bich, N.; Nguyen, H. [Hanoi National University of Education, Chemistry Department (Viet Nam); Van Meervelt, L., E-mail: [KU Leuven, Chemistry Department (Belgium)


    Two 4-substituted 2,2'-bipyridines, namely 4-(ferrocenylethynyl)-2,2'-bipyridine (I) and 4-ferrocenyl-2,2'-bipyridine (II) have been synthesized and fully characterized via single-crystal X-ray diffraction and {sup 1}H and {sup 13}C NMR analyses. The π-conjugated system designed from 2,2'-bipyridine modified with the ferrocenylethynyl and ferrocenyl groups shows the desired planarity. In the crystal packing of I and II, the molecules arrange themselves in head-to-tail and head-to-head motifs, respectively, resulting in consecutive layers of ferrocene and pyridine moieties.

  13. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

    Jubi John


    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  14. Modulating the Affinities of Phosphopeptides for the Human Pin1 WW Domain Using 4-Substituted Proline Derivatives.

    Huang, Kuei-Yen; Horng, Jia-Cherng


    Human Pin1 is involved in cancer developments and has been a pharmaceutical target. Thus, finding a high-affinity inhibitor of Pin1 has become an attractive topic. The WW domain of human Pin1 can recognize the phosphoserine/phosphothreonine-proline (pS/pT-P) motifs, while its PPIase domain catalyzes the cis/trans isomerization of prolyl bonds to regulate the cell cycle. Here we incorporated a series of 4-substituted proline derivatives into the phosphopeptides and investigated their affinities for the WW domain of Pin1 to develop better inhibitors of Pin1. On the basis of the ligand Myt1-T412 [PPA(pT)PP], we synthesized several phosphopeptides in which the proline residue in the pT-P motif was replaced with various 4-substituted proline derivatives. Isothermal titration calorimetry and fluorescence anisotropy analyses show that the replacement of proline with (2S,4R)-4-fluoroproline increases the binding affinity of the peptide. Circular dichroism measurements suggest that a more PPII-like structure of phosphopeptides makes them bind to the WW domain more tightly. Chemical shift perturbation experiments also indicate that (2S,4R)-4-fluoroproline interacts with Trp34 of the WW domain in the binding site. Results of molecular modeling further suggested that a strong C-H···π interaction induced by (2S,4R)-4-fluoroproline is important in enhancing the affinity of the peptide for the WW domain. The results of this study provide new valuable information for designing and developing effective inhibitors of human Pin1. PMID:26406962

  15. A spectrophotometric method for the quantification of an enzyme activity producing 4-substituted phenols: determination of toluene-4-monooxygenase activity.

    Nolan, Louise C; O'Connor, Kevin E


    A spectrophotometric method for the quantitative determination of an enzyme activity resulting in the accumulation of 4-substituted phenols is described in this article. Toluene-4-monooxygenase (T4MO) activity in whole cells of Pseudomonas mendocina KR1 is used to demonstrate this method. This spectrophotometric assay is based on the coupling of T4MO activity with tyrosinase activity. The 4-substituted phenol, produced by the action of T4MO on the aromatic ring of a substituted arene, is a substrate for tyrosinase, which converts phenols to o-quinones. The latter react with the nucleophile 3-methyl-2-benzothiazolinone hydrazone (MBTH) to produce intensely colored products that absorb light maximally at different wavelengths, depending on the phenolic substrate used. The incubation of whole cells of P. mendocina KRI with fluorobenzene resulted in the accumulation of 4-fluorophenol. The coupling of T4MO activity with tyrosinase activity in the presence of fluorobenzene resulted in the formation of a colored product absorbing maximally at 480 nm. The molar absorptivity (epsilon) value for the o-quinone-MBTH adduct formed from 4-fluorophenol was determined experimentally to be 12,827 M(-1) cm(-1) with a linear range of quantification between 2.5 and 75 microM. The whole cell assay was run as a continuous indirect assay. The initial rates of T4MO activity toward fluorobenzene, as determined spectrophotometrically, were 61.8+/-4.4 nmol/min/mg P. mendocina KR1 protein (using mushroom tyrosinase), 64.9+/-4.6 nmol/min/mg P. mendocina KR1 protein (using cell extracts Pseudomonas putida F6), and, as determined by HPLC analysis, 62.6+/-1.4 nmol/min/mg P. mendocina KR1 protein. PMID:16061193

  16. Synthesis, characterization and biological activity of new cyclization products of 3-(4-substituted benzylidene)-2-pyrido[1,2-]pyrimidine 2,4-(3)-diones

    Abha Bishnoi; Suruchi Singh; Anil K Tiwari; Krishna Srivastava; Ram Raghuvir; Chandrakant M Tripathi


    A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl)4-spiro[isoxazole-5,3'-pyrido[1,2-]pyrimidine]-2',4'-dione (3), 3-(4-substituted phenyl)-3-isoxazole[3, 4-]pyrido[1,2-]pyrimidin-4-(3a)-one (4) and 3-(4-substituted phenyl) 3,3a-dihydropyrazolo[3,4-]pyrido[1,2-]pyrimidin-4-(2)-one (5) which consists of the conversion of 2-pyrido[1,2-]pyrimidine-2,4(3)-dione (1) to chalcones (2) and their 1,3-dipolar cycloaddition with appropriate aldoximes to give spiro compounds and heterocyclization using amines to yield isoxazolines and pyrazolines. All the compounds were screened for their antimicrobial and antitubercular activity.

  17. A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.

    Naylor, A; Judd, D B; Lloyd, J E; Scopes, D I; Hayes, A G; Birch, P J


    The synthesis of 4-substituted 1-(arylacetyl)-2-[(alkylamino)methyl]piperazines (10-22, 26, 27, and 30-33) and their activities as kappa-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter series showing the greatest kappa-agonist activity. In particular, methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl) methyl]-1-piperazinecarboxylate (18) displays exceptional potency and selectivity. It showed the following activities in functional in vitro assays: rabbit vas deferens (kappa-specific tissue) IC50 = 0.041 nM, rat vas deferens (mu-specific tissue) IC50 > 10,000 nM, and hamster vas deferens (delta-specific tissue) IC50 > 10,000 nM. Compound 18 is also a highly potent antinociceptive agent, as determined in the mouse acetylcholine-induced abdominal constriction test: ED50 = 0.000 52 mg/kg, sc. The activity of 18 resides solely in its 3(R)-enantiomer. The kappa-agonist activity in both the 4-acyl and the 4-carbamate series is sensitive to the size of the 4-substituent. In addition, it would appear that an appreciable negative electrostatic potential in this region of the molecule is an important requirement for optimal potency. PMID:8393489

  18. Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

    Tian, Yuan; Ma, Yao; Gibeau, Craig R; Lahue, Brian R; Shipps, Gerald W; Strickland, Corey; Bogen, Stéphane L


    Led by the structural information of the screening hit with mDM2 protein, a structure modification of Leu26 moiety of the novel p53-hDM2 inhibitors was conducted. A structure-activity relationship study of 4-substituted piperidines revealed compound 20t with good potencies and excellent CYP450 profiles. PMID:27080185

  19. Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

    Alaux, Sebastien; Kusk, Mie; Sagot, Emanuelle;


    A series of nine L-2,4-syn-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized...

  20. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song


    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways. PMID:24675177

  1. Market scope

    Nova Scotia's Energy Strategy is aimed at opening the electricity market to wholesale competition, allowing eligible wholesale customers (such as municipal distribution utilities) to buy their electricity from competitive sources. The Nova Scotia Electricity Marketplace Governance Committee (EMGC) is concerned that this will not promote long-term competition because these eligible customers form only a very small fraction (1.6 per cent) of the total electricity demand in the province. This report examines the possible extensions of competition beyond the minimum specified in the Energy Strategy. It also identifies approaches that the EMGC may consider, including other potential levels of competition and their associated issues. The report discussed the issue of implementing wholesale competition as it relates to unbundling of the transmission tariff from the cost of energy supply and from the cost of distribution in retail marketing. The stages of expanding the market scope were also described with reference to large industrial customers, medium industrial and large commercial customers, and small commercial and residential customers. The report states that it is unlikely that the transition to an open access transmission market will need to be reversed, as it is likely to be an essential component of any further development. The EMGC feels it could minimize future transition costs and promote future evolution of competition by recommending for an institutional and market structure that is compatible with a broader competitive market

  2. An Efficient Synthesis of Highly Optically Active 4-Substituted-2(5H)-furanones from Chiral 3-Bromo-2(5H)-furanone

    FAN, Xue-E(范雪娥); HUANG, Min(黄敏); HUANG, Hui(黄慧); CHEN, Qing-Hua(陈庆华)


    Highly optically active 4-substituted-2(5H)-furanones 6a-6j were obtained in good yields with de≥98% by the tandem Michael addition/elimination reaction of chiral 3-bromo-2(5H)-furanone (4a), which was conveniently prepared starting from 2-furaldehyde under mild conditions. The products were identified on the basis of their satisfactory elemental analysis and spectroscopic data of IR, UV, 1H NMR, 13C NMR and mass spectra. The stereochemistry and absolute configuration of this type of compounds were established by the X-ray crystallographic study. The reaction provided a short and efficient synthesis of the interesting highly optically active 4-substituted-2(5H)-furanones containing an active pyrimidine and a purine base group.

  3. Structural and microwave dielectric behavior of (Li1/4Nb3/4) substituted ZrxSnyTizO4 (x + y + z = 2) system

    The phase structure, microwave dielectric properties, and their stability with different annealing conditions have been investigated in (Li1/4Nb3/4) substituted ZrxSnyTizO4 system. The sintering temperature of ZrxSnyTizO4 ceramic was lowered from 1500 to 1140 deg. C by (Li1/4Nb3/4) substitution. Both X-ray diffraction (XRD) analysis and electron diffraction (ED) analysis revealed that the (Li1/4Nb3/4) substituted ZrxSnyTizO4 ceramic crystallized as the high-temperature disordered ZrTiO4 phase. As the content of Sn increased from 0.10 to 0.30, the permittivity of the (Zr1-xSnx)(Li1/4Nb3/4)0.4Ti0.6O4 ceramic decreased gradually from 35.5 to 31.5, the Qf value increased from 37,800 to 58,300 GHz, and TCF value shifted slightly from -4.5 to -33.0 ppm deg. C-1. Both the phase structure and microwave dielectric properties of (Zr1-xSnx)(Li1/4Nb3/4)0.4Ti0.6O4 ceramics were stable with annealing conditions.

  4. N-(4-Substituted-benzoyl)-N'-(beta-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods

    Veronika Nagy; Nora Felfoeldi; Balint Konya; Praly, Jean-Pierre; Tibor Docsa; Pal Gergely; Chrysina, Evangelia D.; Tiraidis, Costas; Kosmopoulou, Magda N.; Alexacou, Kyra-Melinda; Konstantakaki, Maria; Leonidas, Demetres D.; Zographos, Spyros E.; Oikonomakos, Nikos G.; Kozmon, Stanislav


    N-(4-Substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas (substituents: Me, Ph, Cl, OH, OMe, NO2, NH2, COOH, and COOMe) were synthesised by ZnCl2 catalysed acylation of O-peracetylated beta-D-glucopyranosyl urea as well as in reactions of O-peracetylated or O-unprotected glucopyranosylamines and acyl-isocyanates. O-deprotections were carried out by base or acid catalysed transesterifications where necessary. Kinetic studies revealed that most of these compounds were low micromolar inhibitors...

  5. Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at the C-4 position of oxazoles.

    Akula, Mahesh; Thigulla, Yadagiri; Davis, Connor; Jha, Mukund; Bhattacharya, Anupam


    A facile synthesis of 4-aryl substituted oxazolo[4,5-c]quinolines has been described via a modified Pictet-Spengler method and using Cu(TFA)2 as a catalyst. The developed methodology directly functionalizes the C-4 position of oxazoles without the aid of any prefunctionalization, in the presence of the more reactive C-2 position in good yields. The versatility of the established method has been demonstrated by its application in the synthesis of 4-substituted oxazolo-[1,8]naphthyridine ring systems. PMID:25574832

  6. Synthesis and antitumor evaluation of some new N4 substituted sulfa pyridine derivatives with studying the synergistic effect of γ-irradiation

    The aim of the present investigation is to synthesize a new class of N4 substituted sulfa pyridine derivatives with anticipated cytotoxic activity. All the newly synthesized compounds were screened for their in-vitro cytotoxic activity against breast cancer cell line (MCF-7) compared to the reference drug Doxorubicin. Also the synergism of the most potent synthesized compounds with γ- radiation was studied. Moreover, a molecular docking study was carried out by docking the most active synthesized compounds in the active site of Cyclin Dependent Kinase 2 receptor to assess their inhibitory effect upon this enzyme as this may have a role in their anticancer activity.

  7. Regioselective synthesis and anti-HIV activity of the novel 2- and 4- substituted pyrazolo [4,5-e] [ 1,2,4]thiadiazines

    Xin Yong Liu; Ren Zhang Yan; Nian Gen Chen; Wen Fang Xu


    The new regioisomer 7-methyl-pyrazolo[4,5-e] [1,2,4]thiadiazine nucleus (5) was synthesized, and its novel mono-N2- or N4-substituted pyrazolo[4,5-e][1,2,4]thiadiazines (6, 7) were regioselectively prepared by deprotonation of N2 or/and N4 atoms with different molar ratio of NaH and alkyl halides. Anti-HIV-1 screening tests showed some compounds to be potent as HIV-1 nonnucleoside reverse transcriptase inhibitors (HIV-1 NNRTIs).(C) 2006 Xin Yong Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  8. Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl-3-(2-naphthyl-1-phenyl-1H-pyrazole derivatives

    Neelima Goel


    Full Text Available Aim: Synthesis of series of 4-(substituted-anilinomethyl-3-(2-naphthyl-1-phenyl-1H-pyrazole derivatives (4a-4k and their in vitro antifungal and antibacterial screening. Materials and Methods: A series of compounds (4a-4k was synthesized through direct reductive amination of 3-(naphthalen-2-yl-1-phenyl-1H-pyrazole-4-carbaldehyde with various substituted aromatic amines using NaBH 4 in the presence of I 2 as reducing agent. The reaction was carried out in anhydrous methanol under neutral conditions at room temperature. The structures of synthesized compounds (4a-4k were established on the basis of IR, 1 H and 13 C-NMR, and mass spectral data. Results: All 4-(substituted-anilinomethyl-3-(2-naphthyl-1-phenyl-1H-pyrazole derivatives (4a-4k were tested in vitro for antifungal and antibacterial activities against different fungal and bacterial strains. Most of the compounds exhibited considerable antifungal activity, but poor antibacterial activity against the test strains. Conclusion: In the series compound 4e, 4g, 4j, and 4k, showed excellent antifungal activity against the fungal strain Aspergillus niger (MTCC 281 and Aspergillus flavus MTCC 277 (% inhibition in the range of 47.7-58.9.

  9. Mass Spectrometric Fragmentation of 1,8-Bis[4-substituted-(oxazolin-2-yl)] anthracenes: Ring-contraction Rearrangement of Oxazoline Ring under Electron-Impact Ionization Conditions


    The mass spectrometric fragmentation of 1,8-bis[4-substituted(oxazolin-2-yl)] anthracenes(AnBOXes) was investigated by using mass-analyzed ion kinetic energy spectrometry under electron-impact ionization conditions. All the compounds could undergo a ring contraction by the loss of an RCH=CH2 molecule to form 1-oxazirinyl-8-(oxazolin-2-yl) anthracene ions, which could further lose an R radical, followed by the loss of oxazoline. These ions could also eliminate an R radical and subsequently undergo ring-contraction rearrangements to lose a CHCH2O fragment and an epoxide molecule, respectively. The ions that are formed could further lose CHCH2O and CH2=CH fragments. Several ring-contraction rearrangements of the oxazoline ring were observed under electron-impact ionization conditions.

  10. Synthesis, properties and colour assessment of some new 5-(3- and 4-substituted phenylazo-4,6-dimethyl-3-cyano-2-pyridones



    Full Text Available A series of 5-(3- and 4-substituted phenylazo-4,6-dimethyl-3-cyano-2-pyridones were synthesized, starting from acetylacetone and arenediazonium salt, followed by condensation with cyanoacetamide using a modified literature procedure. The experimental investigation included modification of the synthetic procedure in terms of solvent, temperature, isolation techniques as well as purification and identification of the products. The azo dyes were characterized by melting point, IR, UV/Vis, 1H NMR and MS data. HPLC analyses were also performed. The 2-hydroxypyridine/ 2-pyridone tautomeric equilibration was found to depend on the polarity of the applied solvents. A colour assessment of the solid dyes and dyed polyester fabrics was also performed and the correlation between the colour and the structure of the dyes is discussed.

  11. Design, synthesis and nonlinear optical properties of (E)-1-(4-substituted)-3-(4-hydroxy-3-nitrophenyl) prop-2-en-1-one compounds

    Saha, Amrita; Shukla, Vijay; Choudhury, Sudip; Jayabalan, J.


    A new series of (E)-1-(4-substituted)-3-(4-hydroxy-3-nitrophenyl) prop-2-en-1-one compounds have been synthesized by Claisen-Schmidt condensation reaction. Nonlinear optical characterization were carried out using z-scan technique with nanosecond pulses. These samples are found to exhibit strong nonlinear absorption at 532 nm and the nonlinear absorption coefficient of these samples exponentially increases with the increase of phonon characteristic energy. This relation speaks the role of phonon in the origin of nonlinear absorption in these compounds. The reported dependence of optical nonlinearity of the chalcone derivatives on the phonon characteristic energy will help in designing similar class of new molecules with high nonlinear coefficients.

  12. Quantifier Scope and Constituency

    Park, J C


    Traditional approaches to quantifier scope typically need stipulation to exclude readings that are unavailable to human understanders. This paper shows that quantifier scope phenomena can be precisely characterized by a semantic representation constrained by surface constituency, if the distinction between referential and quantificational NPs is properly observed. A CCG implementation is described and compared to other approaches.

  13. RADAR PPI Scope Overlay

    National Oceanic and Atmospheric Administration, Department of Commerce — RADAR PPI Scope Overlays are used to position a RADAR image over a station at the correct resolution. The archive maintains several different RADAR resolution...

  14. Concrete decontamination scoping tests

    This report details the research efforts and scoping tests performed at the Idaho Chemical Process Plant using scabbling, chemical, and electro-osmotic decontamination techniques on radiologically contaminated concrete

  15. Disjunction, focus, and scope

    Han, Chung-Hye; Romero, Maribel


    This paper presents the observation that disjunction cannot take wide scope in negative non-wh-questions and declaratives with a preposed negative element. This rules out the alternative question reading for non-wh-questions with preposed negation and the wide-scope or reading for neg-inverted declaratives. We show that effects parallel to the ones associated with preposed negation can be reproduced in affirmative non-wh-questions and declaratives when Focus is involved. We propose that prepo...

  16. Antioxidant, DNA binding and nuclease activities of heteroleptic copper(II) complexes derived from 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols and diimines

    Ravichandran, J.; Gurumoorthy, P.; Imran Musthafa, M. A.; Kalilur Rahiman, A.


    A series of heteroleptic copper(II) complexes of the type [CuL1-4(diimine)](ClO4)2 (1-8) [L1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2‧-bipyridyl (bpy) or 1,10-phenanthroline (phen)], have been synthesized and characterized by spectroscopic methods. The IR spectra of complexes indicate the presence of uncoordinated perchlorate anions and the electronic spectra revealed the square pyramidal geometry with N4O coordination environment around copper(II) nuclei. Electrochemical studies of the mononuclear complexes evidenced one-electron irreversible reduction wave in the cathodic region. The EPR spectra of complexes with g|| (2.206-2.214) and A|| (154-172 × 10-4 cm-1) values support the square-based CuN3O coordination chromophore and the presence of unpaired electron localized in dx-y ground state. Antioxidant studies against DPPH revealed effective radical scavenging properties of the synthesized complexes. Binding studies suggest that the heteroleptic copper(II) complexes interact with calf thymus DNA (CT-DNA) through minor-groove and electrostatic interaction, and all the complexes display pronounced nuclease activity against supercoiled pBR322 DNA.

  17. N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.

    Nagy, Veronika; Felföldi, Nóra; Kónya, Bálint; Praly, Jean-Pierre; Docsa, Tibor; Gergely, Pál; Chrysina, Evangelia D; Tiraidis, Costas; Kosmopoulou, Magda N; Alexacou, Kyra-Melinda; Konstantakaki, Maria; Leonidas, Demetres D; Zographos, Spyros E; Oikonomakos, Nikos G; Kozmon, Stanislav; Tvaroška, Igor; Somsák, László


    N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl) ureas (substituents: Me, Ph, Cl, OH, OMe, NO(2), NH(2), COOH, and COOMe) were synthesised by ZnCl(2) catalysed acylation of O-peracetylated β-d-glucopyranosyl urea as well as in reactions of O-peracetylated or O-unprotected glucopyranosylamines and acyl-isocyanates. O-deprotections were carried out by base or acid catalysed transesterifications where necessary. Kinetic studies revealed that most of these compounds were low micromolar inhibitors of rabbit muscle glycogen phosphorylase b (RMGPb). The best inhibitor was the 4-methylbenzoyl compound (K(i)=2.3μM). Crystallographic analyses of complexes of several of the compounds with RMGPb showed that the analogues exploited, together with water molecules, the available space at the β-pocket subsite and induced a more extended shift of the 280s loop compared to RMGPb in complex with the unsubstituted benzoyl urea. The results suggest the key role of the water molecules in ligand binding and structure-based ligand design. Molecular docking study of selected inhibitors was done to show the ability of the binding affinity prediction. The binding affinity of the highest scored docked poses was calculated and correlated with experimentally measured K(i) values. Results show that correlation is high with the R-squared (R(2)) coefficient over 0.9. PMID:22325154

  18. Spectroscopy and quantum-chemical calculations of nitro-bis-bipyridyl complexes of ruthenium(II) with 4-substituted pyridine ligands

    Reshetova, K. I.; Krauklis, I. V.; Litke, S. V.; Ershov, A. Yu.; Chizhov, Yu. V.


    The luminescence, absorption, and luminescence excitation spectra of complexes cis-[Ru(bpy)2(L)(NO2)]+ [bpy = 2,2'-bipyridyl, L = pyridine, 4-aminopyridine, 4-dimethylaminopyridine, 4-picoline, isonicotinamide, or 4,4'-bipyridyl] in alcoholic (4 : 1 EtOH-MeOH) solutions are studied at 77 K. A linear correlation is established between the energy of the lowest electronically excited metal-toligand charge transfer state d π(Ru) → π*(bpy) of the complexes and the pKa parameter of the free 4-substituted pyridines used as ligands L. The B3LYP/[6-31G(d)+LanL2DZ(Ru)] hybrid density functional method is used to optimize the geometry of complexes and calculate their electronic structure and the charge distribution on the atoms of the nearest environment of ruthenium(II) ions. It is shown that there exists a mutually unambiguous correspondence between the charge on the nitrogen atom of ligands L coordinated in the complex and the pK a parameter of ligands. The calculated energies of the electronically excited metal-to-ligand charge transfer states of complexes linearly (correlation coefficient 0.99) depend on the charge on the nitrogen atom of ligands L, which completely agrees with the experimental data.

  19. Synthesis and antidepressant activities of 4-(substituted-phenyl)tetrazolo[1,5-a]quinazolin-5(4H)-ones and their derivatives.

    Zhang, Hong-Jian; Wang, Shi-Ben; Quan, Zhe-Shan


    A series of novel 4-(substituted-phenyl) tetrazolo[1,5-a]quinazolin-5(4H)-ones (6a-x) and their derivatives with tetrazole and other heterocyclic substituents (7-14) were designed, synthesized, and evaluated for antidepressant activities in mice. Pharmacological tests showed that three compounds (6l, 6u, and 6v) at a dose of 50 mg/kg significantly reduced the immobility time in the forced swimming test. The most active compound was 4-(p-tolyl)tetrazolo[1,5-a]quinazolin-5(4H)-one (6v), which decreased the immobility time by 82.69 % at 50 mg/kg. Moreover, 6v did not affect spontaneous activity in the open-field test, and this effect was comparable to the antidepressant effect of fluoxetine. Noradrenaline (NE) and 5-hydroxytryptamine (5-HT) levels in the brains of mice in the test sample groups significantly increased at a dose of 50 mg/kg compared with that in the control group. The monoamine oxidase (MAO) level of all test groups was reduced, but this result was not significantly different between the groups. Therefore, we can infer that their underlying mechanisms may involve the regulation of brain monoamine neurotransmitter homeostasis, based on the detected content of NE, 5-HT, and MAO in mouse brain tissue. PMID:26251313

  20. ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti- Trypanosoma cruzi agents

    Aguilera-Venegas, Benjamín; Olea-Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal, Fernando; Lapier, Michel; Maya, Juan Diego; Kemmerling, Ulrike; López-Muñoz, Rodrigo


    Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO as aprotic solvent. Two reduction mechanisms were found for these compounds: the first, for compounds bearing a labile hydrogen by following a self-protonation mechanism (ECE steps), and the second, for compounds without labile hydrogen, based on a purely electrochemical reduction mechanism (typical of nitroheterocycles). The electrochemical results were corroborated using ESR spectroscopy allowing us to propose the hyperfine splitting pattern of the nitro-radical, which was later corroborated by the ESR simulation spectra. All these compounds were assayed as growth inhibitors against Trypanosoma cruzi: first, on the non-proliferative (and infective) form of the parasite (trypomastigote stage), and then, the ones that displayed activity, were assayed on the non-infective form (epimastigote stage). Thus, we found four new compounds highly active against T. cruzi. Finally, molecular modeling studies suggest the inhibition of the trypanothione reductase like one of the possible mechanisms involved in the trypanocidal action.

  1. Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies.

    Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Alanazi, Amer M; Asiri, Yousif A; Al-Suwaidan, Ibrahim A; Maarouf, Azza R; Ayyad, Rezk R; Shawer, Taghreed Z


    The potential antitumor activities of a series of 7-(4-substituted piperazin-1-yl)fluoroquinolone derivatives (1-14a,b) using ciprofloxacin and norfloxacin as scaffolds are described. These compounds exhibit potent and broad spectrum antitumor activities using 60 human cell lines in addition to the inherent antibacterial activity. Compounds 1a, 2a, 3b, 6b and 7a were found to be the most potent, while 2b, 5b, and 6a were found to have an average activity. The results of this study demonstrated that compounds 1a, 2a, 3b, 6b and 7a (mean GI50; 2.63-3.09 µM) are nearly 7-fold more potent compared with the positive control 5-fluorouracil (mean GI50; 22.60 µM). More interestingly, compounds 1a, 2a, 3b, 6b and 7a have an almost antitumor activity similar to gefitinib (mean GI50; 3.24 µM) and are nearly 2-fold more potent compared to erlotinib (mean GI50; 7.29 µM). In silico study and ADME-Tox prediction methodology were used to study the antitumor activity of the most active compounds and to identify the structural features required for antitumor activity. PMID:26226179

  2. Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.

    Cao, Dong; Liu, Yibin; Yan, Wei; Wang, Chunyu; Bai, Peng; Wang, Taijin; Tang, Minghai; Wang, Xiaoyan; Yang, Zhuang; Ma, Buyun; Ma, Liang; Lei, Lei; Wang, Fang; Xu, Bixue; Zhou, Yuanyuan; Yang, Tao; Chen, Lijuan


    In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity toward a panel of tumor cell lines at subnanomolar IC50 values. Compound 65 showed potent antiproliferative ability (IC50 values of 7-47 nM) and retained full activity in multidrug resistant cancer cells. Compound 65 caused G2/M phase arrest and interacted with the colchicine-binding site in tubulin, as confirmed by immune-fluorescence staining, microtubule dynamics assays, and competition assays with N,N'-ethylene-bis(iodoacetamide). Compound 65 reduced the cell migration and disrupted capillary-like tube formation in HUVEC cells. Importantly, compound 65 significantly and dose-dependently reduced tumor growth in four xenografts models including paclitaxel sensitive and resistant ovarian tumors (A2780s and A2780/T), adrmicycin sensitive and resistant breast tumors (MCF-7 and MCF-7/ADR), suggesting that compound 65 is a promising novel antimitotic compound for the potential treatment of cancer. PMID:27213819

  3. Facile preparation of a 4-substituted [2,6-14C]pyridine: synthesis of [14C]SK and F 105809

    [14C]Formaldehyde was used in a nucleophile-assisted iminium ion cyclization with N-benzyl-3-butynylamine to provide N-benzyl-4-iodo-1,2,5,6-tetrahydro [2,6-14C2]pyridine. Palladium-catalyzed coupling of this vinyl iodide with the organozinc derivative 2 gave the corresponding 4-arylated tetrahydropyridine. Treatment of this compound at elevated temperatures with Pd/Al2O3 in nitrobenzene solution caused hydrogenolysis of the benzyl group and aromization, generating the 4-substituted [2,6-14C2]pyridine 4 in good overall radiochemical yield from [14C]formaldehyde. In high yields, compound 4 was converted via the methylsulfide [14C]SK and F 105561 (1b) to the methylsulfinyl compound [14C]SK and F 105809 (1a). It is proposed that, during the iminium ion cyclization, randomization of label between the 2- and 6-positions of the tetrahydropyridine ring occurs as the result of rapid equilibration between alkynyl and allenyl iminium ions, prior to cyclization. (author)

  4. 1, 3-Dipolar cycloaddition reactions: Synthesis of 5-benzyl-1-(2',4'-dibromophenyl)-3-(4"-substituted phenyl)-3a,4,6,6a-tetrahydro-1, 5-pyrrolo[3,4-]pyrazole-4,6-dione derivatives

    Manpreet Kaur; Baldev Singh; Baljit Singh


    1,3-Dipolar cycloaddition of nitrilimines 3 with -benzyl maleimide 4 has provided 5-benzyl-1-(2',4'-dibromophenyl)-3-(4"-substituted phenyl)-3a,4,6,6a-tetrahydro-1,5-pyrrolo[3,4-]pyrazole-4,6-dione derivatives 5 in excellent yield as the only isomer through a concerted pathway.

  5. Spectrophotometric, voltammetric and cytotoxicity studies of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives: A combined experimental-computational study

    Akgemci, Emine Guler; Saf, Ahmet Ozgur; Tasdemir, Halil Ugur; Türkkan, Ercan; Bingol, Haluk; Turan, Suna Ozbas; Akkiprik, Mustafa


    In this study, 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) and its novel N(4) substituted derivatives were synthesized and characterized by different techniques. The optical band gap of the compounds and the energy of HOMO were experimentally examined by UV-vis spectra and cyclic voltammetry measurements, respectively. Furthermore, the conformational spaces of the compounds were scanned with molecular mechanics method. The geometry optimization, HOMO and LUMO energies, the energy gap of the HOMO-LUMO, dipole moment of the compounds were theoretically calculated by the density functional theory B3LYP/6-311++G(d,p) level. The minimal electronic excitation energy and maximum wavelength calculations of the compounds were also performed by TD-DFT//B3LYP/6-311++G(d,p) level of theory. Theoretically calculated values were compared with the related experimental values. The combined results exhibit that all compounds have good electron-donor properties which affect anti-proliferative activity. The cytotoxic effects of the compounds were also evaluated against HeLa (cervical carcinoma), MCF-7 (breast carcinoma) and PC-3 (prostatic carcinoma) cell lines using the standard MTT assay. All tested compounds showed antiproliferative effect having IC50 values in different range. In comparison with that of HMAT, it was obtained that while ethyl group on 4(N)-substituted position decreased in potent anti-proliferative effect, the phenyl group on the position increased in anti-proliferative effect for the tested cancer cell line. Considering the molecular energy parameters, the cytotoxicity activities of the compounds were discussed.

  6. Prediction of binding modes and affinities of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide inhibitors to the carbonic anhydrase receptor by docking and ONIOM calculations.

    Samanta, Pabitra Narayan; Das, Kalyan Kumar


    Inhibition activities of a series of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamides against the human carbonic anhydrase II (HCAII) enzyme have been explored by employing molecular docking and hybrid QM/MM methods. The docking protocol has been employed to assess the best pose of each ligand in the active site cavity of the enzyme, and probe the interactions with the amino acid residues. The docking calculations reveal that the inhibitor binds to the catalytic Zn(2+) site through the deprotonated sulfonamide nitrogen atom by making several hydrophobic and hydrogen bond interactions with the side chain residues depending on the substituted moiety. A cross-docking approach has been adopted prior to the hybrid QM/MM calculation to validate the docked poses. A correlation between the experimental dissociation constants and the docked free energies for the enzyme-inhibitor complexes has been established. Two-layered ONIOM calculations based on QM/MM approach have been performed to evaluate the binding efficacy of the inhibitors. The inhibitor potency has been predicted from the computed binding energies after taking into account of the electronic phenomena associated with enzyme-inhibitor interactions. Both the hybrid (B3LYP) and meta-hybrid (M06-2X) functionals are used for the description of the QM region. To improve the correlation between the experimental biological activity and the theoretical results, a three-layered ONIOM calculation has been carried out and verified for some of the selected inhibitors. The charge transfer stabilization energies are calculated via natural bond orbital analysis to recognize the donor-acceptor interaction in the binding pocket of the enzyme. The nature of binding between the inhibitors and HCAII active site is further analyzed from the electron density distribution maps. PMID:26619075

  7. Cosmetology: Scope and Sequence.

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  8. Synthesis of 7-Methoxy-4'-substituted Flavones%7-甲氧基-4'-取代黄酮类化合物的合成

    安景云; 刘湘; 杨青青; 陆小倩


    In this paper,an expedient procedure to synthesize 7-methoxy-4'-substituted flavones from 2-hydroxy-4-methoxyacetophenone and 4-substitutedbenzoyl chlorides was discovered and optimized. The four flavones were obtained via the successive reactions of esterification, rearrangement and cyclization. The esterification was carried out for 0. 5 ~ 4 h at room temperature, with the mole ratio of 1: (1. 0 ~ 1. 3 ) [ n ( 2-hydroxy-4-methoxyacetophenone) : n (4-substitutedbenzoyl chlorides ) ] ; the rearrangement was performed for 2 ~6 h at 30 ~ 60 ℃ ;the cyclization took place for 2 ~5 h at 80 ~ 100 ℃ ,with the catalyst of acetic acid/sulfuric acid ( V( acetic acid) : V( sulfuric acid )=(15~20):l]. Under the optimum reaction conditions, the target products were obtained with overall yields of 50% ~ 75% and with a purity of more than 95%. The structures of the compounds were confirmed by 'HNMR,IR and MS.%以2-羟基-4-甲氧基苯乙酮和4种对位取代的苯甲酰氯为原料,经过酯化、重排、成环3步反应方便地合成了4种7-甲氧基-4’-取代黄酮类化合物,并对各步反应条件进行了优化,得到的优化条件为:酯化反应∶常温反应0.5~4 h,n(2-羟基-4-甲氧基苯乙酮)∶n(对位取代苯甲酰氯)=1∶(1.0~1.3);重排反应:反应温度30 ~ 60℃,反应时间2~6 h;成环反应:反应温度80~100℃,反应时间2~5h,催化剂CH3COOH/H2SO4两者体积比(15~20)∶1.目标产物总收率50%~75%,HPLC分析纯度达95%以上.化合物结构经1HNMR、IR和MS证实.

  9. Interconversion study in 1,4-substituted six-membered cyclohexane-type rings. Structure and dynamics of trans-1,4-dibromo-1,4-dicyanocyclohexane.

    Bain, Alex D; Baron, Maximo; Burger, Steven K; Kowalewski, Valdemar J; Rodríguez, Marina Belén


    Cyclohexane is an extremely flexible molecule that oscillates, at room temperature, between two clearly distinct and extreme conformations that cannot be distinguished at room temperature; so much so that the NMR spectrum is a single line that includes all 12 protons be they axial or equatorial. This raises the interesting question as to what happens when there are equal substituents at the 1 and 4 carbon atoms of the ring. Therefore substitution in the 1,4-positions in the cyclohexane ring has been the subject of considerable interest because some form of interconversion between extreme conformations could lead to the existence of a rather unusual behavior. To study this problem, the interconversion in (di- or tetra-1,4)-substituted six-membered cyclohexane-type rings, trans-1,4-dibromo-1,4-dicyanocyclohexane, was found to be a particularly suitable candidate. Although X-ray diffraction studies on the crystalline solid found the molecule to be centrosymmetric, it still shows a significant dipole moment μ in solution, as determined with a procedure that leads to the vapor phase values of μ. Furthermore, the low magnetic field proton NMR spectrum at ambient temperature appears as a single line, a situation that changes with increasing field intensity and different solvents. Both these effects are attributed to dynamics, because small distortions can easily disrupt the exact cancellation of the individual dipoles (which are quite strong) associated with each end of the molecule. The molecule can exist in two forms, with both the bromines in an axial geometry or both in an equatorial position. Interconversion between these forms is observed, as in the parent cyclohexane. The single NMR line observed at low magnetic fields is due to fast exchange and requires that the two forms have roughly equal populations. Spectra obtained at low temperature confirm this, and variable-temperature studies allow measurement of the rates, leading to an enthalpy of activation of 62 k

  10. Frozen Scope and Grammatical Optimization

    Freedman, Michael


    The literature on quantifier scope has repeatedly observed that some otherwise expected permutations of scope taking elements are unavailable. Various methods have been proffered explaining these facts. This thesis aims to unify three disparate areas where the scope of operators seems to be frozen: the interaction of universal quantifiers with…

  11. SYNTHESIS OF SOME NEW 1-SUBSTITUTED 3-TRIFLUROMETHYL-5-PHENYL-4- (SUBSTITUTED PHENYL AZO PYRAZOLES AS ANTIFUNGAL AGENTS Synthese einiger NEW 1-substituierten 3-Trifluormethyl-5-phenyl-4- (Substituiertes Phenyl AZO PYRAZOLE als Antipilzmittel

    Vineeta Sareen, Vineeta Khatri and Prakash Jain


    Full Text Available Some new fluorine containing azo pyrazoles have been synthesized by the condensation of hydrazono derivatives (obtained by the reaction of 1, 3-diketone with diazonium salts in the presence of sodium acetate, with substituted hydrazines to give 1-substituted-3-trifluoromethyl- 5-phenyl-4-(substituted phenyl azo pyrazoles. The structure of these compounds are confirmed on the basis of elemental analysis and spectral studies.


    Surender Kumar


    Multimedia includes a combination of text, still images, audio, animation, video, and interactivity content forms. At present, scope of Multimedia course is much more than Animation, the reason behind is its course contents and future career options, a person after doing this course can opt any field such as Graphic Designer, Layout Artist, Image Editor, Template Artist, Interface Designer, Web Designer, Web Master, Presentation Artist, Audio/Video Editor, 3D Animator, Game Designer, Sound Pr...

  13. SCOPE New Photographic Practices

    Arthur, Mervyn; Baseman, Jordan; Behr, Bernd; Biswas, Sutapa; Chance, Veronique; Cobbing, William; Coldwell, Paul; Cross, David; Dobai, Sarah; Douglas, Lorrice; Drabble, Neil; Gunning, Lucy; Hamann, Sigune; Haywood, Thomas; Ingham, Mark


    The photographic practices brought together for this exhibition and publication provide a broad scope of how photographic and lens based media may be used in order to have a visceral and conceptual impact. The methods on show demonstrate the way that artists might pick and choose from the approaches, processes and debates that have arisen through the medium’s history. This collection of work features film, video and photography that demand a renegotiation of the relationship between camera, s...

  14. Scoping studies for NET

    Scoping studies for NET using the SUPERCOIL system code are described. Capital cost optimized devices satisfying constraints imposed on stresses/strains, fields, access, etc. are compared. The main objectives are to determine what impact the main design characteristics, performance objectives and underlying plasma physics assumptions have on the parameters and cost of NET. A complete picture for choosing the main parameters of NET is developed and illustrated by the main NET study points used during the conceptual design phase. (orig.)

  15. Synthesis and antifungal activity of 1- ( 1 H-1, 2,4-triazol-1-yl) -2- (2,4-difluorophenyl)-3-(4-substituted acyl piperazin-1-yl)-2-propanols

    LIANG Shuang; LIU Chao-mei; ZHU Jie; HE Qiu-qin; JIANG Yuan-ying; CAO Yong-bin


    Objective: To study the effect of fluconzole derivatives from a side chain containing 4-substituted acyl piperazin-1-yl on antifungal activity. Methods: Fourteen title compounds were synthesized and confirmed by the elementary analysis, 1HNMR and IR spectra. Five deep fungal strains and 3 shallow fungal strains were chosen as the experimental strains. Minimum inhibitory concentrations(MICs) of all title compounds were determined by the method recommended by the National Committee for Clinical Laboratory Standards (NCCLS) using RPMI 1640 test medium. Results: Among the 14title compounds, 12 were first reported. The results of preliminary antifungal test showed that all the title compounds exhibited potent antifungal activities to a certain extent. The activity of 4 compounds were more than 4 times as high as that of fluconazole and equal to that of ketoconazole against Candida albicans in vitro(MIC80 value≤0. 125 μg/ml). Conclusion:Introduction of a side chain containing 4-substituted acyl piperazin-l-yl into the main part of fluconazole has important influence on antifungal activities of title compounds.

  16. The Scope of Design Studying

    JIN Yin; Ren Wenying


    This article trys to discuss the scope of design studying in two fields.Firstly, design has three meanings: wide design, art design and industrial design.Secondly, design studying has five contents: cultural, philosophical, methodological, produced and marketable trends.

  17. The Scope of General Theory



    A “holy war†is being fought within comparative historical sociology between deductivists and inductivists over the scope of general theory. The issues include broad versus narrow scope conditions, explicit versus contingent theorizing, and theory testing versus theory building. The irony of the conflict is that each side makes ample use of the other's product, despite condemning its progenitor. The authors offer a hierarchical approach to qualitative comparative analysis (QCA) as a method...

  18. 32 CFR 989.18 - Scoping.


    ..., and impacts to be considered in the EIS (40 CFR 1508.25). The EPF must send scripts for scoping... initiate the public scoping process (40 CFR 1501.7) to determine the scope of issues to be addressed and to... soliciting written comments to conducting public scoping meetings (see 40 CFR 1501.7 and 1506.6(e))....

  19. Subject categories and scope descriptions

    This document is one in a series of publications known as the ETDE/INIS Joint Reference Series. It defines the subject categories and provides the scope descriptions to be used for categorization of the nuclear literature for the preparation of INIS and ETDE input by national and regional centres. Together with the other volumes of the INIS Reference Series it defines the rules, standards and practices and provides the authorities to be used in the International Nuclear Information System and ETDE. A complete list of the volumes published in the INIS Reference Series may be found on the inside front cover of this publication. This INIS/ETDE Reference Series document is intended to serve two purposes: to define the subject scope of the International Nuclear Information System (INIS) and the Energy Technology Data Exchange (ETDE) and to define the subject classification scheme of INIS and ETDE. It is thus the guide to the inputting centres in determining which items of literature should be reported, and in determining where the full bibliographic entry and abstract of each item should be included in INIS or ETDE database. Each category is identified by a category code consisting of three alphanumeric characters. A scope description is given for each subject category. The scope of INIS is the sum of the scopes of all the categories. With most categories cross references are provided to other categories where appropriate. Cross references should be of assistance in finding the appropriate category; in fact, by indicating topics that are excluded from the category in question, the cross references help to clarify and define the scope of the category to which they are appended. A Subject Index is included as an aid to subject classifiers, but it is only an aid and not a means for subject classification. It facilitates the use of this document, but is no substitute for the description of the scope of the subject categories

  20. Residential ventilation standards scoping study

    McKone, Thomas E.; Sherman, Max H.


    The goals of this scoping study are to identify research needed to develop improved ventilation standards for California's Title 24 Building Energy Efficiency Standards. The 2008 Title 24 Standards are the primary target for the outcome of this research, but this scoping study is not limited to that timeframe. We prepared this scoping study to provide the California Energy Commission with broad and flexible options for developing a research plan to advance the standards. This document presents the findings of a scoping study commissioned by the Public Interest Energy Research (PIER) program of the California Energy Commission to determine what research is necessary to develop new residential ventilation requirements for California. This study is one of three companion efforts needed to complete the job of determining the ventilation needs of California residences, determining the bases for setting residential ventilation requirements, and determining appropriate ventilation technologies to meet these needs and requirements in an energy efficient manner. Rather than providing research results, this scoping study identifies important research questions along with the level of effort necessary to address these questions and the costs, risks, and benefits of pursuing alternative research questions. In approaching these questions and corresponding levels of effort, feasibility and timing were important considerations. The Commission has specified Summer 2005 as the latest date for completing this research in time to update the 2008 version of California's Energy Code (Title 24).

  1. Aircraft Mechanics: Scope and Sequence.

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for an aircraft mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and…

  2. MANGANESE PERCHLORATE CATALYZED EFFICIENT GREENER SONOCHEMICAL SYNTHESIS OF ARYL-14-H-DIBENZO [3, J] XANTHENES AND 4-SUBSTITUTED 2H-CHROMEN-2-ONES Manganperchlorat katalysierten EFFICIENT GREENER Sonochemische Synthese von Aryl-14-H-DIBENZO [3, J] Xanthene und 4-substituierten 2H-chromen-2-one

    Bhupinder Kaur, Anupama Parmar and Harish Kumar


    Full Text Available Hydrated manganese perchlorate under ultrasonic irradiation is found to be an efficient, greener protocol for the synthesis of Aryl-14-H-dibenzo [α,j] xanthenes and 4- substituted 2H-Chromen-2-ones. The present methodology offers momentous improvement over various options for the synthesis of Aryl-14-H-dibenzo [α,j] xanthenes and 4-substituted 2HChromen-2-ones with regard to yield of the product, reaction time, simplicity in operation and green aspects by avoiding toxic solvents and high temperature.

  3. 78 FR 32372 - Notice of Scope Rulings


    ...). \\2\\ See Notice of Scope Rulings, 78 FR 9370 (February 8, 2013). Scope Rulings Made Between October 1... Republic of China Requestor: Tobacco Import USA (``TIU''); hookah charcoal tablets imported by TIU are...

  4. 76 FR 10558 - Notice of Scope Rulings


    ... of Scope Rulings, 75 FR 79339 (December 20, 2010). This current notice covers all scope rulings and... Threaded Rod from the People's Republic of China. Requestor: Elgin Fastener Group; hex collared stud is...

  5. 78 FR 59653 - Notice of Scope Rulings


    ...). \\2\\ See Notice of Scope Rulings, 78 FR 42934 (July 18, 2013). Scope Rulings Made Between April 1... (PTFE) resin products made from raw, unfilled PTFE powder from Russia and the People's Republic of...

  6. 75 FR 79339 - Notice of Scope Rulings


    ... Rulings, 75 FR 52311 (August 25, 2010). This current notice covers all scope rulings and anticircumvention... its turbocharger spindle units are within the scope of the antidumping duty order; requested...

  7. 78 FR 9370 - Notice of Scope Rulings


    ....225(o). \\2\\ See Notice of Scope Rulings, 77 FR 52313 (August 29, 2012). Scope Rulings Made Between.... Indah Kiat Pulp & Paper Tbk, and Paper Max, Ltd. (collectively ``APP''); (1) APP's Ningbo Fold...

  8. Making Patent Scopes Exceed the Technological Scopes of Scientific Inventions

    Beukel, Karin

    This paper presents the results of a grounded theory study of the transformation of scientific discoveries into patented inventions. Using an algebraic interpretive approach, the narratives collected during interviews are analyzed as Bayesian inferences and the developed theory is tested. The...... findings recast the relationship between science and patents as a process in which the way the transformation of the scientific invention is handled has an effect on the breadth of the patent scope. Unleashing patent scope surplus is dependent on processes related to abstraction and cognitive variety......, which can be mobilized by patent experts with both an in-depth understanding of the scientific discovery, due to their educational background in the life sciences, and capabilities within the legal framework for patenting. More specifically, the findings reveal previously unreported aspects of the...

  9. 76 FR 73596 - Notice of Scope Rulings


    ... Scope Rulings, 76 FR 31301 (May 31, 2011). This current notice covers all scope rulings and...: C2F, Inc.; its PRO-0203-01 black journal and PTL-018121 black bound-stitched journal are not within... scope of the antidumping duty order; requested October 12, 2010. A-570-900: Diamond Sawblades and...

  10. Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

    Devambatla, Ravi Kumar Vyas; Namjoshi, Ojas A; Choudhary, Shruti; Hamel, Ernest; Shaffer, Corena V; Rohena, Cristina C; Mooberry, Susan L; Gangjee, Aleem


    The design, synthesis, and biological evaluations of eight 4-substituted 5-methyl-furo[2,3-d]pyrimidines are reported. Synthesis involved N(4)-alkylation of N-aryl-5-methylfuro[2,3-d]pyrimidin-4-amines, obtained from Ullmann coupling of 4-amino-5-methylfuro[2,3-d]pyrimidine and appropriate aryl iodides. Compounds 3, 4, and 9 showed potent microtubule depolymerizing activities, while compounds 6-8 had slightly lower potency. Compounds 4, 6, 7, and 9 inhibited tubulin assembly with IC50 values comparable to that of combretastatin A-4 (CA-4). Compounds 3, 4, and 6-9 circumvented Pgp and βIII-tubulin mediated drug resistance, mechanisms that can limit the efficacy of paclitaxel, docetaxel, and the vinca alkaloids. In the NCI 60-cell line panel, compound 3 exhibited GI50 values less than 10 nM in 47 of the cell lines. In an MDA-MB-435 xenograft model, compound 3 had statistically significant antitumor effects. The biological effects of 3 identify it as a novel, potent microtubule depolymerizing agent with antitumor activity. PMID:27213719

  11. Product Scope and Endogenous Fluctuations

    Weder, Mark; Pavlov, Oscar


    Recent empirical evidence suggests that product creation is procyclical and it occurs largely within existing fi rms. Motivated by these findings, the current paper investigates the role of intrafi rm product scope choice in a general equilibrium economy with oligopolistic producers. We show that the multi-product nature of fi rms makes the economy signifi cantly more susceptible to sunspot equilibria. The estimated indeterminate model generates artifi cial business cycles that closely resemb...

  12. The Scope of Existential Spatiality

    Dimitri Ginev


    The paper does not suggest an outline of a comprehensive theory of existential spatiality. Its aim is much moderate – to reveal those aspects of the constitution of meaning within the totality of being in the world which delineate the scope of the problematic under investigation. Since these aspects are addressed by various kinds of constitutional analysis of meaning, a special effort is devoted to overcoming discrepancies among three basic phenomenological discourses – hermeneutic phenomenol...

  13. The EarthScope Portal

    Baru, C.; Ahern, T.; Anderson, G.; Behrends, K.; Casey, R.; Hoyt, B.; Kamb, L.; Lin, K.; Meertens, C.; Memon, A.; Muench, J.; Stolte, C.; Weertman, B.; Weiland, C.


    The EarthScope Portal is being developed in order to provide a unified, single-point of access to EarthScope data products from USArray, PBO, and SAFOD experiments. The portal will feature basic search and data access capabilities to allow users to discover and access EarthScope data using spatial, temporal, and other metadata- based search conditions. In this presentation, we will describe the features and design of the portal, which is being developed by a team consisting of GEON (Geosciences Network,, IRIS, UNAVCO, and Stanford. The portal search module invokes Web services developed by IRIS, UNAVCO, and Stanford to search for EarthScope data in the archives at each of these locations. The Web services provide information about all resources (data) that match the specified search conditions. Users will be able to select from the returned data sets, add selected data to a "data cart", and request the selected data to be packaged for download to the user. The initial services being defined are for "station discovery", to find which stations are available for specified spatial and temporal bounds, and "data discovery", to find the data sets that are available from the stations. Users will subsequently be able to choose the specific datasets, which will be assembled in a user "workspace" and available for download. The EarthScope Portal leverages the significant portal development efforts of the GEON Project at the San Diego Supercomputer Center, SDSC (, and the development of Web services interfaces at the three data archive facilities. The portal is implemented using the open source GridSphere portal software infrastructure which supports the well-known Java portlet interface, viz. JSR 168 or the Portlet API. It uses a set of "core" portlets that have been developed in GEON for Data Registration, Search, and Workspace Services. We will provide a report on the current state of development of the Portal. A

  14. IDC Reengineering Phase 2 Project Scope.

    Harris, James M.


    This report provides a brief description of the scope of the IDC Reengineering Phase 2 project. It describes the goals and objectives of reengineering, the system definition, and the technical scope of the system. REVISIONS Version Date Author/Team Revision Description Authorized by 1.0 9/25/2014 SNL IDC Reengineering Team Unlimited Release for I2 M. Harris 1.1 28/01/2015 IDC Reengineering Team Align with previous IDC scope document E. Tomuta

  15. 42 CFR 456.150 - Scope.


    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals,...

  16. 46 CFR 162.050-1 - Scope.


    ... APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-1 Scope. (a) This subpart contains... facility authorized to conduct approval tests; (5) Marking requirements; and (6) Factory...

  17. Anger perceptually and conceptually narrows cognitive scope.

    Gable, Philip A; Poole, Bryan D; Harmon-Jones, Eddie


    For the last 50 years, research investigating the effect of emotions on scope of cognitive processing was based on models proposing that affective valence determined cognitive scope. More recently, our motivational intensity model suggests that this past work had confounded valence with motivational intensity. Research derived from this model supports the idea that motivational intensity, rather than affective valence, explains much of the variance emotions have on cognitive scope. However, the motivational intensity model is limited in that the empirical work has examined only positive affects high in approach and negative affects high in avoidance motivation. Thus, perhaps only approach-positive and avoidance-negative states narrow cognitive scope. The present research was designed to clarify these conceptual issues by examining the effect of anger, a negatively valenced approach-motivated state, on cognitive scope. Results revealed that anger narrowed attentional scope relative to a neutral state and that attentional narrowing to anger was similar to the attentional narrowing caused by high approach-motivated positive affects (Study 1). This narrowing of attention was related to trait approach motivation (Studies 2 and Study 3). Anger also narrowed conceptual cognitive categorization (Study 4). Narrowing of categorization related to participants' approach motivation toward anger stimuli. Together, these results suggest that anger, an approach-motivated negative affect, narrows perceptual and conceptual cognitive scope. More broadly, these results support the conceptual model that motivational intensity per se, rather than approach-positive and avoidance-negative states, causes a narrowing of cognitive scope. PMID:26011662

  18. 32 CFR 775.8 - Scoping.


    ... proposed action (40 CFR 1501.7). This process also serves to deemphasize insignificant issues, narrowing the scope of the EIS process accordingly (40 CFR 1500.4(g)). Scoping results in the identification by the proponent of the range of actions, alternatives, and impacts to be considered in the EIS (40...

  19. 40 CFR 21.1 - Scope.


    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Scope. 21.1 Section 21.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SMALL BUSINESS § 21.1 Scope. This part establishes procedures for the issuance by EPA of the statements, referred to in section 7(g) of the Small Business...

  20. 10 CFR 850.1 - Scope.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed...

  1. 10 CFR 766.100 - Scope.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the Special Assessment of...

  2. 50 CFR 520.2 - Scope.


    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Scope. 520.2 Section 520.2 Wildlife and Fisheries MARINE MAMMAL COMMISSION PUBLIC AVAILABILITY OF AGENCY MATERIALS § 520.2 Scope. (a) These... techniques and procedures, or (vi) Endanger the life or physical safety of law enforcement personnel;...

  3. 78 FR 42934 - Notice of Scope Rulings


    ...). \\2\\ See Notice of Scope Rulings, 78 FR 32372 (May 30, 2013). Scope Rulings Made Between January 1... duty order; March 7, 2013. A-570-970 and C-570-971: Multilayered Wood Flooring From the People's... orders, and ASC's ladders, models ASE, ASH, and DJX3-W, and strip door mounting brackets are within...

  4. 19 CFR 177.0 - Scope.


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Scope. 177.0 Section 177.0 Customs Duties U.S...) ADMINISTRATIVE RULINGS § 177.0 Scope. This part relates to the issuance of rulings to importers and other... Act of 1930, as amended). Nor do the provisions of part 177 apply to requests for decisions of...

  5. 34 CFR 601.1 - Scope.


    ... 34 Education 3 2010-07-01 2010-07-01 false Scope. 601.1 Section 601.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION INSTITUTION AND LENDER REQUIREMENTS RELATING TO EDUCATION LOANS General § 601.1 Scope. This...

  6. 19 CFR 123.0 - Scope.


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 123.0 Section 123.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO § 123.0 Scope. This part contains special regulations pertaining to Customs procedures at the Canadian and...

  7. The Scope of the 1992 Water Convention

    Merkouris, Panos; Fitzmaurice, Malgosia; Tanzi, Attila; McIntyre, Owen; Kolliopoulos, Alexandros; Rieu-Clarke, Alistair; Kinna, Rémy


    This Chapter will be devoted to the scope of the 1992 Water Convention. Its focus will be the general legal framework of the Convention, as the detailed analysis of its normative scope and the overview of its underlying legal principles will be discussed elsewhere in this publication. Suffice to say

  8. 77 FR 9893 - Notice of Scope Rulings


    ... Rulings, 76 FR 73596 (November 29, 2011). This current notice covers all scope rulings and... Distributing, Inc.'s cast smart splitter is not within the scope of the antidumping duty order; June 6, 2011. A...: Ashley Furniture Industries Inc.; certain polyurethane mirrors and an upholstered mirror are ] not...

  9. 16 CFR 316.1 - Scope.


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Scope. 316.1 Section 316.1 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS CAN-SPAM RULE § 316.1 Scope. This part implements the Controlling the Assault of Non-Solicited Pornography and Marketing Act of...

  10. 32 CFR 516.27 - Scope.


    ... 32 National Defense 3 2010-07-01 2010-07-01 true Scope. 516.27 Section 516.27 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Individual Liability § 516.27 Scope. This subpart guidance when DA personnel, as a result of...

  11. 32 CFR 516.38 - Scope.


    ... 32 National Defense 3 2010-07-01 2010-07-01 true Scope. 516.38 Section 516.38 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Environmental Litigation § 516.38 Scope. This subpart contains guidance, policies, and...

  12. 31 CFR 103.80 - Scope.


    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 103.80 Section 103.80 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS Administrative Rulings § 103.80 Scope. This subpart...

  13. 30 CFR 90.1 - Scope.


    ... STANDARDS-COAL MINERS WHO HAVE EVIDENCE OF THE DEVELOPMENT OF PNEUMOCONIOSIS General § 90.1 Scope. This Part... areas of underground coal mines and who have evidence of the development of pneumoconiosis to work in...

  14. 50 CFR 216.102 - Scope.


    ... General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities § 216.102 Scope. The taking of small numbers of marine mammals under section 101(a)(5) (A) through (D) of...

  15. 16 CFR 432.1 - Scope.


    ... HOME ENTERTAINMENT PRODUCTS § 432.1 Scope. (a) Except as provided in paragraph (b) of this section... entertainment purposes, such as for example, radios, record and tape players, radio-phonograph and/or...

  16. The Scope of Microeconomics: A Comment.

    Hansen, Lee W.


    This article offers an analysis of Strober's paper (see SO516707) on the scope of microeconomics. It concludes that useful suggestions are made regarding modifications needed in the Joint Council's "Framework" and "Master Curriculum Guide." (JDH)

  17. 77 FR 50084 - Notice of Scope Rulings


    ... Rulings, 77 FR 38767 (June 29, 2012). Scope Rulings Completed Between January 1, 2012, and March 31, 2012... and Paper Mills, PT. Indah Kiat Pulp & Paper Tbk, and Paper Max, Ltd. (collectively ``APP''); (1)...

  18. 12 CFR 747.1 - Scope.


    ... NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS, ADJUDICATIVE HEARINGS, RULES OF PRACTICE AND PROCEDURE, AND INVESTIGATIONS Uniform Rules of Practice and Procedure § 747.1 Scope. This subpart prescribes uniform rules of practice and procedure applicable...

  19. 48 CFR 22.1500 - Scope.


    ... APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Prohibition of Acquisition of Products Produced by Forced or Indentured Child Labor 22.1500 Scope. This subpart applies to acquisitions of supplies that...

  20. Scope of nanotechnology in modern textiles

    This review article demonstrates the scope and applications of nanotechnology towards modification and development of advanced textile fibers, yarns and fabrics and their processing techniques. Basically, it summarizes the recent advances made in nanotechnology and its applications to cotton textil...

  1. Solomon Islands: Malaita Hub scoping report

    Schwarz, A.M.; Andrew, N.; Govan, H.; Harohau, D.; Oeta, J.


    The CGIAR Research Program (CRP) Aquatic Agricultural Systems (AAS) will target five countries, including Solomon Islands. The proposed hubs for Solomon Islands were to cover most provinces, referencing the Western, Central and Eastern regions. Scoping of the initial ‘Central’ hub was undertaken in Guadalcanal, Malaita and Central Islands provinces and this report details findings from all three. As scoping progressed however, it was agreed that, based on the AAS context and priority need...

  2. 48 CFR 36.302 - Scope of work.


    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scope of work. 36.302... Scope of work. The agency shall develop, either in-house or by contract, a scope of work that defines the project and states the Government's requirements. The scope of work may include criteria...

  3. 77 FR 63309 - Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping...


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping Period for the Planned Constitution Pipeline Project On October 24, 2012, the...

  4. Harry Potter and the sorcerer's scope: latent scope biases in explanatory reasoning.

    Khemlani, Sangeet S; Sussman, Abigail B; Oppenheimer, Daniel M


    What makes a good explanation? We examine the function of latent scope, i.e., the number of unobserved phenomena that an explanation can account for. We show that individuals prefer narrow latent scope explanations-those that account for fewer unobserved effects-to broader explanations. In Experiments 1a-d, participants found narrow latent scope explanations to be both more satisfying and more likely. In Experiment 2 we directly manipulated base rate information and again found a preference for narrow latent scope explanations. Participants in Experiment 3 evaluated more natural explanations of unexpected observations, and again displayed a bias for narrow latent scope explanations. We conclude by considering what this novel bias tells us about how humans evaluate explanations and engage in causal reasoning. PMID:21264612

  5. The ParaScope parallel programming environment

    Cooper, Keith D.; Hall, Mary W.; Hood, Robert T.; Kennedy, Ken; Mckinley, Kathryn S.; Mellor-Crummey, John M.; Torczon, Linda; Warren, Scott K.


    The ParaScope parallel programming environment, developed to support scientific programming of shared-memory multiprocessors, includes a collection of tools that use global program analysis to help users develop and debug parallel programs. This paper focuses on ParaScope's compilation system, its parallel program editor, and its parallel debugging system. The compilation system extends the traditional single-procedure compiler by providing a mechanism for managing the compilation of complete programs. Thus, ParaScope can support both traditional single-procedure optimization and optimization across procedure boundaries. The ParaScope editor brings both compiler analysis and user expertise to bear on program parallelization. It assists the knowledgeable user by displaying and managing analysis and by providing a variety of interactive program transformations that are effective in exposing parallelism. The debugging system detects and reports timing-dependent errors, called data races, in execution of parallel programs. The system combines static analysis, program instrumentation, and run-time reporting to provide a mechanical system for isolating errors in parallel program executions. Finally, we describe a new project to extend ParaScope to support programming in FORTRAN D, a machine-independent parallel programming language intended for use with both distributed-memory and shared-memory parallel computers.

  6. Consumer Behavior: Its Scope and Boundary.

    Sirgy, M. Joseph

    Consumer behavior can be conceptualized by introducing a theoretical framework which defines its scope and boundary and identifies six developmental levels. The infancy stage, Level I, is the study of consumer behavior referred to as the scientific study of psychological structure and process dynamics of individuals consuming an economic good…

  7. 19 CFR 174.0 - Scope.


    ... applicable to Canadian and Mexican exporters and producers regarding administrative review and appeal of...) PROTESTS § 174.0 Scope. This part deals with the administrative review of decisions of the port director, including the requirements for the filing of protests against such decisions, amendment of protests,...

  8. 21 CFR 26.3 - Scope.


    ... PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN... Provisions for Pharmaceutical Good Manufacturing Practices § 26.3 Scope. (a) The provisions of this subpart... inspections and the good manufacturing practices (GMP's) requirements. (c) Appendix B of this subpart...

  9. 14 CFR 77.21 - Scope.


    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Scope. 77.21 Section 77.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE OBJECTS... Alaska or Pacific Airman's Guide and Chart Supplement; or (2) A planned or proposed airport or an...

  10. 14 CFR 77.11 - Scope.


    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Scope. 77.11 Section 77.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE OBJECTS... supplemental notices 48 hours before the start and upon the completion of certain construction or...

  11. 22 CFR 309.13 - Scope.


    ... offset; (3) 5 CFR part 550, subpart K, setting forth the minimum requirements for executive agency regulations on salary offset; and (4) 31 CFR parts 900 through 904, the Federal Claims Collections Standards... PEACE CORPS DEBT COLLECTION Salary Offset § 309.13 Scope. (a) The provisions of this section apply...

  12. 24 CFR 17.1 - Scope; definitions.


    ... Tort Claims Act issued by the Attorney General (31 FR 16616; 28 CFR part 14). (c) The terms Department and Organizational unit are defined in 24 CFR part 5. Procedures ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Scope; definitions. 17.1 Section...

  13. 45 CFR 1355.10 - Scope.



  14. 7 CFR 3.51 - Scope.


    ... Secretary of Agriculture DEBT MANAGEMENT Administrative Wage Garnishment § 3.51 Scope. (a) This subpart applies to any agency that administers a program that gives rise to a delinquent nontax debt owed to the United States and to any agency that pursues recovery of such debt. (b) This subpart shall...

  15. 20 CFR 901.0 - Scope.


    ...' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 § 901.0 Scope. This part contains rules governing the performance of actuarial services under the Employee Retirement Income Security Act of...

  16. 21 CFR 17.1 - Scope.


    ... act that relate to prescription drug marketing practices. (b) Section 303(f)(1) of the act authorizing... mitigation strategies for drugs. (d) Section 303(g)(1) of the act authorizing civil money penalties for... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Scope. 17.1 Section 17.1 Food and Drugs FOOD...

  17. 16 CFR 1101.2. - Scope.


    ... Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Background § 1101.2. Scope. Section 6(b) and these... Law 110-278, 122 Stat. 2602 (July 17, 2008)....

  18. 77 FR 38767 - Notice of Scope Rulings


    ... Rulings, 77 FR 32568 (June 1, 2012). This current notice covers all scope rulings and anticircumvention...-968: Aluminum Extrusions from the People's Republic of China Requestor: Rubbermaid; cleaning system...: Aluminum Extrusions from the People's Republic of China Requestor: Rubbermaid; non-extruded...

  19. 21 CFR 878.1 - Scope.


    ... PLASTIC SURGERY DEVICES General Provisions § 878.1 Scope. (a) This part sets forth the classification of general and plastic surgery devices intended for human use that are in commercial distribution. (b) The... listings, a general and plastic surgery device that has two or more types of uses (e.g., used both as...

  20. 43 CFR 15.1 - Scope.


    ...: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.1 Scope. The State of Florida has established a similar coral reef preserve on an area situated shoreward of a line three geographic miles from Key Largo and contiguous to the Key Largo Coral Reef Preserve. It is the policy of...

  1. 20 CFR 411.100 - Scope.


    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Scope. 411.100 Section 411.100 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Introduction § 411... managers to assist us in the administration of the Ticket to Work program. (e) Subpart E...

  2. 48 CFR 23.1000 - Scope.


    ... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Federal Compliance With Right-To-Know Laws and Pollution Prevention Requirements 23.1000 Scope...) Compliance with right-to-know laws and pollution prevention requirements; (b) Implementation of...

  3. 5 CFR 179.202 - Scope.


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Scope. 179.202 Section 179.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS... implementing the Federal Claims Collection Act (31 U.S.C. 3711 et seq., 4 CFR parts 101-105, 38 CFR 1.900...

  4. 21 CFR 892.1 - Scope.


    ... DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.1 Scope. (a) This part sets forth the classification of radiology devices... devices, as required by § 807.87. (c) To avoid duplicative listings, a radiology device that has two...

  5. 44 CFR 206.343 - Scope.


    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope. 206.343 Section 206.343 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... orientation which is unrelated to development is not subject to the requirements of these regulations....

  6. 32 CFR 319.3 - Scope.


    ... INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.3 Scope. (a) Any individual who is a citizen of the United States or... Defense Intelligence Agency. (b) These rules apply to those systems of records: (1) Maintained by the Defense Intelligence Agency; (2) For which the Defense Intelligence Agency prescribes the content...

  7. 46 CFR 58.16-1 - Scope.


    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-1 Scope. (a) This subpart prescribes standards for the use of liquefied petroleum gas for heating and cooking on inspected vessels,...

  8. 34 CFR 686.30 - Scope.


    ... 34 Education 3 2010-07-01 2010-07-01 false Scope. 686.30 Section 686.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION TEACHER EDUCATION ASSISTANCE FOR COLLEGE AND HIGHER EDUCATION (TEACH) GRANT...

  9. 14 CFR 171.21 - Scope.


    ... FACILITIES NON-FEDERAL NAVIGATION FACILITIES Nondirectional Radio Beacon Facilities § 171.21 Scope. (a) This... radio beacon facilities that are to be involved in the approval of instrument flight rules and air traffic control procedures related to those facilities. (b) A nondirectional radio beacon (“H”...

  10. Interdisciplinary Doctoral Research Supervision: A Scoping Review

    Vanstone, Meredith; Hibbert, Kathy; Kinsella, Elizabeth Anne; McKenzie, Pam; Pitman, Allan; Lingard, Lorelei


    This scoping literature review examines the topic of interdisciplinary doctoral research supervision. Interdisciplinary doctoral research programs are expanding in response to encouragement from funding agencies and enthusiasm from faculty and students. In an acknowledgement that the search for creative and innovative solutions to complex problems…

  11. On the Scope of Egalitarian Justice

    Joseph Heath


    Full Text Available It is not clear whether the social contract is supposed to merely supplement the unequal gains that individuals are able to make through the exercise of their natural endowments with a set of equal gains secured through social cooperation, or whether the social contract must also compensate individuals for the effects of these natural inequalities, so that they literally become all equal. The issue concerns, in effect, whether natural inequality falls within the scope of egalitarian justice. I think it is fair to say that the majority of egalitarians assume that the principle of equality imposes an obligation to redress natural inequality. Yet there is no consensus on this issue. David Gauthier has made the rejection of the principle of redress a central component of his project. It has often escaped notice that John Rawls also rejects the principle of redress. Thus it is not just anti-egalitarians who reject the principle of redress. There is a current of egalitarian thought– which we might call, for lack of a better term, narrow-scope egalitarianism – which also rejects this principle. In this paper, I would like to show that there is considerable wisdom in the narrow-scope egalitarian position. Many of the problems that lead theorists to reject egalitarianism in its entirety are a consequence, not of the principle of equality per se, but rather of the commitment to redress natural inequality. The narrow-scope view avoids all of these difficulties.

  12. The widening scope of mentalizing: a discussion

    Fonagy, P.; Bateman, A


    The editors of this special issue have commissioned us to bring together some of the conceptual and empirical research presented in six intriguing papers that illustrate the widening scope of mentalization. Our discussion will look at each paper in turn, but bring ideas and findings from the other papers into focus when relevant.

  13. 49 CFR 234.1 - Scope.


    ... TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE ACTION PLANS General § 234.1 Scope. This part imposes minimum maintenance, inspection, and testing standards for highway-rail grade crossing warning... particular identified States to develop State highway-rail grade crossing action plans. This part does...

  14. 76 FR 31301 - Notice of Scope Rulings


    ... Rulings, 76 FR 10558 (February 25, 2011). This current notice covers all scope rulings and... Furniture from the People's Republic of China. Requestor: Stork Craft Manufacturing; whether its infant... tissue paper from the Socialist Republic of Vietnam (``Vietnam'') are circumventing the antidumping...

  15. Examining Young Students' Problem Scoping in Engineering Design

    Watkins, Jessica; Spencer, Kathleen; Hammer, David


    Problem scoping--determining the nature and boundaries of a problem--is an essential aspect of the engineering design process. Some studies from engineering education suggest that beginning students tend to skip problem scoping or oversimplify a problem. However, the ways these studies often characterize students' problem scoping often do not…

  16. 40 CFR 35.917-4 - Planning scope and detail.


    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Planning scope and detail. 35.917-4 Section 35.917-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... Planning scope and detail. (a) Initially, the geographic scope of step 1 grant assistance shall be based...

  17. 45 CFR 703.3 - Scope of subject matter.


    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Scope of subject matter. 703.3 Section 703.3... AND FUNCTIONS OF STATE ADVISORY COMMITTEES § 703.3 Scope of subject matter. The scope of the subject matter to be dealt with by Advisory Committees shall be those subjects of inquiry or study with which...

  18. Reduced attentional scope in cocaine polydrug users.

    Lorenza S Colzato

    Full Text Available Cocaine is Europe's second preferred recreational drug after cannabis but very little is known about possible cognitive impairments in the upcoming type of recreational cocaine user (monthly consumption. We asked whether recreational use of cocaine impacts early attentional selection processes. Cocaine-free polydrug controls (n = 18 and cocaine polydrug users (n = 18 were matched on sex, age, alcohol consumption, and IQ (using the Raven's progressive matrices, and were tested by using the Global-Local task to measure the scope of attention. Cocaine polydrug users attended significantly more to local aspects of attended events, which fits with the idea that a reduced scope of attention may be associated with the perpetuation of the use of the drug.

  19. Revising the Complex Economics of Patent Scope

    Howells, John

    Merges and Nelson claim to have provided an empirically grounded argument that pioneer patents of 'broad' scope are used to block technological development. It is widely understood in both law and economics that they have, as they claim, faulted Kitch's 'prospect theory' of patents, a theory that a...... function of patents is to enable the coordinated development of novel technical ideas. This article is a critical review of Merges and Nelson's historical empirical evidence. I find that, first, 'broad' scope is only implicated in one of the examples cited by Merges and Nelson as supportive evidence - the...... Wright brothers' warped-wing patent; second, that strict development block, defined as the prevention, or retardation of the development of technology understood to be capable of useful development, was not illustrated by any of their examples. Therefore I conclude that their general thesis is not...

  20. Latin American forensic pathology: scope and needs

    Gabriel M. Fonseca


    Full Text Available Pathology pertains to the study of a disease; from ancient times it has sought to explain the cause of death through postmortem examination. The advancement of science and technology has led to a greater definition of roles and has favored its development through different subspecialties among which we stands out forensic pathology. This discipline has its own characteristics, scope, case series, procedures and terminology. Likewise, although forensic pathology does not differ substantially from clinical pathology, significant differences can be found between the Anglo American approach and the Latin American approach. Beyond semantics of these alleged differences, the article reviews the concepts involved and discusses the scope and requirements needed to qualify experts, in the understanding that globalizing criteria should establish new paradigms and define the specific roles of the specialty.

  1. Synthesis and characterization of new 2-amino-4-(substituted phenyl-6-(7’’-methoxy, 3’’,4’’-dihydro, 2’’,2’’-dimethyl-2hbenzopyran pyrimidines and their bio evaluation

    Murthy Y.L.N.


    Full Text Available A series of eight novel 2-amino-4-(substituted phenyl-6-(7"- methoxy, 3",4"-dihydro, 2",2"-dimethyl-2H-benzopyran pyrimidines were designed and synthesized by utilizing benzene-1,3-diol as starting material. The structures of the isolated products (6a-h were established through 1HNMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. The synthesized compounds were utilized for screening antimicrobial properties against gram positive (Bacillus pumilus, Bacillus subtilis, Streptococcus faecalis, gram negative bacteria (Enterococcus faecalis, Escheria coli, Proteus vulgaris and fungi (Pencillian expasom, Aspergillus niger, Candida albicans using Ampicillin and Ketoconazole. Most of the compounds showed moderate to high antibacterial and antifungal activities against studied strains with inhibition zones between 8 and 30 mm.

  2. Superposition and Entanglement from Quantum Scope

    Wang, Dong-sheng


    The abstract framework of quantum mechanics (QM) causes the well-known weirdness, which leads to the field of foundation of QM. We constructed the new concept, i.e., scope, to lay the foundation of quantum coherence and openness, also the principles of superposition and entanglement. We studied analytically and quantitatively the quantum correlations and information, also we discussed the physical essence of the existed entanglement measures. We compared with several other approaches to the f...

  3. Industrial Scope of Agglomeration Economies in Brazil

    Ana Maria Bonomi Barufi; Eduardo A. Haddad, Peter Nijkamp


    The tendency towards urbanization in the emerging world accompanied by the constant pursuit for higher productivity prompts an urge for studies aiming at understanding agglomeration economies. In the context of Brazil, a country with extremely high regional disparities, exploring this issue is important not only for private stakeholders, but also for public policy practitioners. In the framework of static agglomeration effects, we investigate the industrial scope of agglomeration economies in...

  4. The Scope of Moore's Ethical Intuitionism

    Ali Akbar Abdolabadi


    One of the most fundamental questions about G. E. Moore's ethical intuitionism relates to its scope. Does Moore's ethical intuitionism only relate to the value - ethical terms and the ethical judgments or propositions containing them, or beside those terms and judgments or propositions, it relate to the obligatory ethical terms and the ethical judgments or propositions containing them? In this paper, we will try to show, by an analytic - critical method, that contrary to som...

  5. How the Cloud Stretches the SOA Scope

    Lakshmanan G


    Full Text Available In this article, we will describe how the enterprise serviceoriented-architecture (SOA scope is stretched with the advent of cloud computing. With the help of the case study of a fictitious global retailer, we will demonstrate the process for identifying cloud scenarios. Also, we will come across an emerging breed of distributed applications—both on-premise and in the Cloud—and discuss the integration considerations for building them.

  6. Framing maternal morbidity: WHO scoping exercise

    Vanderkruik, Rachel C; Tunçalp, Özge; Chou, Doris; Say, Lale


    Background Maternal morbidity estimations are not based on well-documented methodologies and thus have limited validity for informing efforts to address the issue and improve maternal health. To fill this gap, maternal morbidity needs to be clearly defined, driving the development of tools and indicators to measure and monitor maternal health. This article describes the scoping exercise conducted by the World Health Organization’s Department of Reproductive of Health and Research (WHO/RHR), a...

  7. Home care safety markers: a scoping review.

    Macdonald, Marilyn; Lang, Ariella; Storch, Jan; Stevenson, Lynn; Donaldson, Susan; Barber, Tanya; Iaboni, Kristine


    Safety in home care is a new research frontier, and one in which demand for services continues to rise. A scoping review of the home care literature on chronic obstructive pulmonary disease and congestive heart failure was thus completed to identify safety markers that could serve to develop our understanding of safety in this sector. Results generated seven safety markers: (a) Home alone; (b) A fixed agenda in a foreign language; (c) Strangers in the home; (d) The butcher, the baker, the candlestick maker; (e) Medication mania; (f) Out of pocket: The cost of caring at home; and (g) My health for yours: Declining caregiver health. PMID:23679662

  8. Objectives, scope and programme of work

    The objectives and scope for Working Group 1 were: (1) to estimate needs for nuclear energy and correlated needs for uranium and heavy water according to different fuel cycle strategies; (2) to review uranium availability; (3) to review heavy water availability; (4) to review thorium availability; (5) to consider special needs of developing countries. Sub-Groups were formed to carry out specific parts of the evaluation as follows: Sub-Group A: Nuclear Growth and Demand. Sub-Group B: Nuclear Fuel Resources. Sub-Group C: Technical and Political Aspects of Uranium and Thorium Exploration and Production. Sub-Group D: Heavy Water Availability

  9. Tokamak Engineering Technology Facility scoping study

    Stacey, W.M. Jr.; Abdou, M.A.; Bolta, C.C.


    A scoping study for a Tokamak Engineering Technology Facility (TETF) is presented. The TETF is a tokamak with R = 3 m and I/sub p/ = 1.4 MA based on the counterstreaming-ion torus mode of operation. The primary purpose of TETF is to demonstrate fusion technologies for the Experimental Power Reactor (EPR), but it will also serve as an engineering and radiation test facility. TETF has several technological systems (e.g., superconducting toroidal-field coil, tritium fuel cycle, impurity control, first wall) that are prototypical of EPR.

  10. Hardware Support for Safety-critical Java Scope Checks

    Rios Rivas, Juan Ricardo; Schoeberl, Martin


    Memory management in Safety-Critical Java (SCJ) is based on time bounded, non garbage collected scoped memory regions used to store temporary objects. Scoped memory regions may have different life times during the execution of a program and hence, to avoid leaving dangling pointers, it is necessary...... in terms of execution time for applications where cross-scope references are frequent. Our proposal was implemented and tested on the Java Optimized Processor (JOP)....

  11. Requirements scoping outside product lines : Systematic Literature Review and Survey

    Kollu, Ravichandra Kumar


    Context: Scoping is admitted as a key activity in Market Driven Software Development for handling the constant inflow of requirements. It helps in identifying the features, domains and products which help for gaining economic benefits in Software Product Line (SPL) development. Beyond SPL, managing the scope of the project is a major risk for project management. Continuously changing scope creates a congestion state to handle the requirements inflow which causes negative consequences like sco...

  12. Donkey anaphora is in-scope binding

    Chris Barker


    Full Text Available We propose that the antecedent of a donkey pronoun takes scope over and binds the donkey pronoun, just like any other quantificational antecedent would bind a pronoun. We flesh out this idea in a grammar that compositionally derives the truth conditions of donkey sentences containing conditionals and relative clauses, including those involving modals and proportional quantifiers. For example, an indefinite in the antecedent of a conditional can bind a donkey pronoun in the consequent by taking scope over the entire conditional. Our grammar manages continuations using three independently motivated type-shifters, Lift, Lower, and Bind. Empirical support comes from donkey weak crossover (*He beats it if a farmer owns a donkey: in our system, a quantificational binder need not c-command a pronoun that it binds, but must be evaluated before it, so that donkey weak crossover is just a special case of weak crossover. We compare our approach to situation-based E-type pronoun analyses, as well as to dynamic accounts such as Dynamic Predicate Logic. A new 'tower' notation makes derivations considerably easier to follow and manipulate than some previous grammars based on continuations. BibTeX info See also the interactive tutorial about the system in this paper

  13. CMS Phase II Upgrade Scope Document

    Butler, J; Klute, M; Mans, J; Silvestris, L; on behalf of the CMS, Collaboration; CERN. Geneva. The LHC experiments Committee; LHCC


    The High-Luminosity LHC (HL-LHC) has been identified as the highest priority program in High Energy Physics by both the European Strategy Group and the US Particle Physics Project Prioritization Panel. To fulfil the full potential of this program, which includes the study of the nature of the Higgs boson, the investigation of the properties of any newly discovered particles in the upcoming LHC runs, and the extension of the mass reach for further discoveries, an integrated luminosity of 3000 fb-1 will have to be accumulated by the end of the program. In preparation for operation at the HL-LHC , CMS has documented the necessary upgrades and their expected costs in a Technical Proposal submitted to the CERN LHC Committee (LHCC) in mid-2015. The material presented in the current “Scope Document” provides additional information to assist the LHCC and the CERN Resource Review Board (RRB) in their review of the CMS upgrade. The document commences with a summary of the process followed to develop the scope of t...

  14. Optical fiber scope for inspecting fuel assembly

    Since a fiber scope has only one objective section, it has to observe a plurality of places successively. Then, if the time for the observation is long, the objective section is deteriorated by radiation rays, which causes a problem of interrupting the observation and increasing operator's radiation dose. In view of the above, one or two light guides are combined with an image guide to form one objective section, and a plurality of them are formed in parallel and gathered as a comb-like shape. A prism is put into a window of the objective section and resins are filled or a glass cover is attached, to make the objective section smooth and flat. Compared with the case of using only one objective section, it is no more necessary for successive observation, and objection can be conducted at one time. For example, if a fiber scope having nine objective sections is used for observing 8 x 8 arrangement fuel assembly, the observation time is shortened to 1/9. Since the prism, the glass cover, and the resins are used for making the window flat, cruds deposited between the optical fiber and a reflection mirror are easily removed, to obtain clear images. (N.H.)

  15. Quarry residuals RI/FS scoping document

    The purpose of this document is to serve as a planning tool for the implementation of the Quarry Residual Remedial Investigation/Feasibility Study (RI/FS) process and to provide direct input to revising and updating the 1988 Work Plan for the Weldon Spring Site Remedial Action Project (WSSRAP) Remedial Investigation/Feasibility Study-Environmental Impact Statement for the Weldon Spring Site (RI/FS-EIS) (Peterson et al. 1988) for this effort. The scoping process is intended to outline the tasks necessary to develop and implement activities in compliance with the Comprehensive Environmental Response, Compensation and Liability Act-National Environmental Policy Act (CERCLA-NEPA) process from detailed planning through the appropriate decision document. In addition to scoping the entire process, this document will serve as the primary tool for planning and accomplishing all activities to be developed in the Quarry Residual RI/FS Work Plan. Subsequent tasks are difficult to plan at this time. 10 refs., 5 figs., 5 tabs

  16. EarthScope Education and Outreach: Accomplishments and Emerging Opportunities

    Robinson, S.; Ellins, K. K.; Semken, S. C.; Arrowsmith, R.


    EarthScope's Education and Outreach (E&O) program aims to increase public awareness of Earth science and enhance geoscience education at the K-12 and college level. The program is distinctive among major geoscience programs in two ways. First, planning for education and public engagement occurred in tandem with planning for the science mission. Second, the NSF EarthScope program includes funding support for education and outreach. In this presentation, we highlight key examples of the program's accomplishments and identify emerging E&O opportunities. E&O efforts have been collaboratively led by the EarthScope National Office (ESNO), IRIS, UNAVCO, the EarthScope Education and Outreach Subcommittee (EEOSC) and PI-driven EarthScope projects. Efforts by the EEOSC, guided by an EarthScope Education and Outreach Implementation Plan that is periodically updated, focus EarthScope E&O. EarthScope demonstrated early success in engaging undergraduate students (and teachers) in its mission through their involvement in siting USArray across the contiguous U.S. Funded E&O programs such as TOTLE, Illinois EarthScope, CEETEP (for K-12), InTeGrate and GETSI (for undergraduates) foster use of freely available EarthScope data and research findings. The Next Generation Science Standards, which stress science and engineering practices, offer an opportunity for alignment with existing EarthScope K-12 educational resources, and the EEOSC recommends focusing efforts on this task. The EEOSC recognizes the rapidly growing use of mobile smart devices by the public and in formal classrooms, which bring new opportunities to connect with the public and students. This will capitalize on EarthScope's already prominent social media presence, an effort that developed to accomplish one of the primary goals of the EarthScope E&O Implementation Plan to "Create a high-profile public identity for EarthScope" and to "Promote science literacy and understanding of EarthScope among all audiences through

  17. Prioritising Project Scope Definition Elements in Public Building Projects

    Mohammed K Fageha


    Full Text Available A complete definition of the scope of a project upfront during early stages ensures smooth and successful implementation during the project execution. This research identifies and prioritises project scope definition elements for public buildings in Saudi Arabia. Elements that could significantly contribute to complete project scope definition package at pre-project planning stage are identified and their interrelationship determined and prioritised. Using the Project Definition Rating Index (PDRI as a basis, the study uses analytical network process (ANP technique based on data obtained from project managers who have been involved in public sector projects in Saudi Arabia. Data collection and analysis was conducted in three steps. The first step involved identification of scope definition elements while the second involved an investigation into interrelationships among the elements. In the third step, ANP was used to determine the weight of the elements’ importance in terms of contribution to project scope definition completeness. Finally, Pareto analysis was used to prioritise and assess the distribution pattern of the elements. The outcome from this research is the prioritisation of project scope definition elements for public building projects in Saudi Arabia. The prioritised list developed indicates the importance of project scope definition elements. It should help project management teams identify elements to consider when evaluating project scope definition for completeness at the pre-project planning stage. Keywords: Project scope definition, pre-project planning, prioritising, public building projects, Saudi Arabia, Analytical Network Process (ANP

  18. 48 CFR 28.203-4 - Substitution of assets.


    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Substitution of assets. 28... assets. An individual surety may request the Government to accept a substitute asset for that currently... may agree to the substitution of assets upon determining, after consultation with legal counsel,...

  19. Scope of algae as third generation biofuels

    Shuvashish eBehera


    Full Text Available An initiative has been taken to develop different solid, liquid and gaseous biofuels as the alternative energy resources. The current research and technology based on the third generation biofuels derived from algal biomass have been considered as the best alternative bioresource that avoids the disadvantages of first and second generation biofuels. Algal biomass have been investigated for the implementation of economic conversion processes producing different biofuels such as biodiesel, bioethanol, biogas, biohydrogen and other valuable co-products. In the present review, the recent findings and advance developments in algal biomass for improved biofuel production. This review discusses about the importance of the algal cell contents, various strategies for product formation through various conversion technologies, and its future scope as an energy security.

  20. Automation scope at Roxboro generating station

    Many fossil fired power plant have replaced their aging unit control hardware with modern DCS technology. This paper describes a jointly sponsored project by EPRI, Carolina Power and Light Co. (CP and L) and ABB, to implement plant automation functions which would complement DCS technology, and result in improvements in plant operations in terms of heat rate, availability, and operations cost. These will be demonstrated at CP and L's Roxboro Station, a 4 unit coal fired plant with total capacity of nearly 2,477 MW. The scope of this four year project includes installation of a plant-wide information management system, automation of unit testing, implementation of advanced controls, intelligent alarms, operator advisory functions, and a plant-wide simulator, as well as support for plant unit economic dispatch

  1. NASA Scope and Subject Category Guide


    This guide provides a simple, effective tool to assist aerospace information analysts and database builders in the high-level subject classification of technical materials. Each of the 76 subject categories comprising the classification scheme is presented with a description of category scope, a listing of subtopics, cross references, and an indication of particular areas of NASA interest. The guide also includes an index of nearly 3,000 specific research topics cross referenced to the subject categories. The portable document format (PDF) version of the guide contains links in the index from each input subject to its corresponding categories. In addition to subject classification, the guide can serve as an aid to searching databases that use the classification scheme, and is also an excellent selection guide for those involved in the acquisition of aerospace literature. The CD-ROM contains both HTML and PDF versions.

  2. The AuScope Geodetic VLBI Array

    Lovell, J E J; Reid, P B; McCulloch, P M; Baynes, B E; Dickey, J M; Shabala, S S; Watson, C S; Titov, O; Ruddick, R; Twilley, R; Reynolds, C; Tingay, S J; Shield, P; Adada, R; Ellingsen, S P; Morgan, J S; Bignall, H E; 10.1007/s00190-013-0626-3


    The AuScope geodetic Very Long Baseline Interferometry array consists of three new 12 m radio telescopes and a correlation facility in Australia. The telescopes at Hobart (Tasmania), Katherine (Northern Territory) and Yarragadee (Western Australia) are co-located with other space geodetic techniques including Global Navigation Satellite Systems (GNSS) and gravity infrastructure, and in the case of Yarragadee, Satellite Laser Ranging (SLR) and Doppler Orbitography and Radiopositioning Integrated by Satellite (DORIS) facilities. The correlation facility is based in Perth (Western Australia). This new facility will make significant contributions to improving the densification of the International Celestial Reference Frame in the Southern Hemisphere, and subsequently enhance the International Terrestrial Reference Frame through the ability to detect and mitigate systematic error. This, combined with the simultaneous densification of the GNSS network across Australia will enable the improved measurement of intrapl...


    Jeffrey Brown; Bruce Exstrum


    This report summarizes the activities carried out by Aspen Systems Corporation in support of the Department of Energy's Rebuild America program during the period from October 9, 1999 to October 31, 2004. These activities were in accordance with the Scope of Work contained in a GSA MOBIS schedule task order issued by the National Energy Technology Laboratory. This report includes descriptions of activities and results in the following areas: deployment/delivery model; program and project results; program representative support activities; technical assistance; web site development and operation; business/strategic partners; and training/workshop activities. The report includes conclusions and recommendations. Five source documents are also provided as appendices.

  4. Observational therapeutics: Scope, challenges, and organization

    Rama Vaidya


    Full Text Available The importance of Observational Therapeutics in the progress of medicine has been neglected in the current era of the hierarchal position imparted to Randomized Controlled Trials (RCTs for new drug discovery and practice of evidence-based medicine. There is a need to reflect on the reason for many new drugs being withdrawn during post marketing surveillance. There are several examples in literature where drug-discovery has originated initially from keen clinical and / or laboratory observations. The roots of these discoveries have often been from observations made by practitioners of traditional medicine including Ayurveda. The present article draws attention to the scope and challenges for observational therapeutics. There is an urgent need for the meticulous planning for a systematic organization of developing observational therapeutics, with a full understanding of its strengths and limitations.

  5. Scoping Review of the Zika Virus Literature.

    Lisa A Waddell

    Full Text Available The global primary literature on Zika virus (ZIKV (n = 233 studies and reports, up to March 1, 2016 has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations 56.6% (132/233, pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis 38.2% (89/233 and ZIKV studies (molecular characterisation and in vitro evaluation of the virus 18.5% (43/233. There has been little reported in the primary literature on ZIKV vectors (12/233, surveillance for ZIKV (13/233, diagnostic tests (12/233 and transmission (10/233. Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233, of which 62/233 were case studies or case series, while fewer (24/233 used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health.

  6. EarthScope's Transportable Array in Alaska

    Busby, R. W.; Woodward, R.; Hafner, K.


    Since 2003, EarthScope has been installing a network of seismometers, known as the Transportable Array-across the continental United States and southern Canada. The station deployments will be completed in the Conterminous US in the fall of 2013. Beginning in October, 2013, and continuing for 5 years, EarthScope's Transportable Array plans to create a grid of seismic sensors in approximately 300 locations In Alaska and Western Canada. The proposed station grid is 85 km, and target locations will supplement or enhance existing seismic stations operating in Alaska. When possible, they will also be co-located with existing GPS stations constructed by the Plate Boundary Observatory. We review the siting plans for stations, the progress towards reconnaissance and permitting, and detail the engineering concept of the stations. In order to be able to determine the required site conditions and descriptions of installation methods to the permitting agencies, the National Science Foundation (NSF) has been supporting exploratory work on seismic station design, sensor emplacement and communication concepts appropriate for the challenging high-latitude environment that is proposed for deployment. IRIS has installed several experimental stations to evaluate different sensor emplacement schemes both in Alaska and the lower-48 U.S. The goal of these tests is to maintain or enhance a station's noise performance while minimizing its footprint and the equipment, materials, and overall expense required for its construction. Motivating this approach are recent developments in posthole broadband seismometer design and the unique conditions for operating in Alaska, where most areas are only accessible by small plane or helicopter, and permafrost underlies much of the region. IRIS has experimented with different portable drills and drilling techniques to create shallow holes (1-5M) in permafrost and rock outcrops. Seasonal changes can affect the performance of seismometers in different

  7. Scoping Review of the Zika Virus Literature


    The global primary literature on Zika virus (ZIKV) (n = 233 studies and reports, up to March 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations) 56.6% (132/233), pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis) 38.2% (89/233) and ZIKV studies (molecular characterisation and in vitro evaluation of the virus) 18.5% (43/233). There has been little reported in the primary literature on ZIKV vectors (12/233), surveillance for ZIKV (13/233), diagnostic tests (12/233) and transmission (10/233). Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233), of which 62/233 were case studies or case series, while fewer (24/233) used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health. PMID:27244249

  8. Scope Underspecification with Tree Descriptions: Theory and Practice

    Koller, Alexander; Thater, Stefan; Pinkal, Manfred

    Scope underspecification is the standard technique used in computational linguistics to deal efficiently with scope ambiguities, a certain type of semantic ambiguity. Its key idea is to not enumerate all semantic readings from a syntactic analysis during or after parsing as in more traditional approaches to semantic construction, but to derive a single, compact underspecified representation (USR) that describes the set of readings instead.

  9. 34 CFR 686.1 - Scope and purpose.


    ..., DEPARTMENT OF EDUCATION TEACHER EDUCATION ASSISTANCE FOR COLLEGE AND HIGHER EDUCATION (TEACH) GRANT PROGRAM Scope, Purpose, and General Definitions § 686.1 Scope and purpose. The TEACH Grant program awards grants to students who intend to teach, to help meet the cost of their postsecondary education. In...

  10. 47 CFR 80.1187 - Scope of communication.


    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Scope of communication. 80.1187 Section 80.1187... MARITIME SERVICES Voluntary Radio Installations Mobile-Satellite Stations § 80.1187 Scope of communication. Ship earth stations must be used for telecommunications related to the business or operation of...

  11. 12 CFR 363.1 - Scope and definitions.


    ... ANNUAL INDEPENDENT AUDITS AND REPORTING REQUIREMENTS § 363.1 Scope and definitions. (a) Applicability... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope and definitions. 363.1 Section 363.1... management report requirement of § 363.2(b) and the internal control reporting requirement of §...

  12. 28 CFR 544.100 - Purpose and scope.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 544.100 Section 544.100 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Inmate Library Services § 544.100 Purpose and scope. The Bureau of Prisons provides inmates...

  13. 30 CFR 775.1 - Scope and purpose.


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope and purpose. 775.1 Section 775.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR SURFACE COAL... ADMINISTRATIVE AND JUDICIAL REVIEW OF DECISIONS § 775.1 Scope and purpose. This part provides requirements...

  14. 32 CFR 775.1 - Purpose and scope.


    ... Quality Regulations for Implementing the Procedural Provisions of NEPA, 40 CFR 1500-1508, and the... 32 National Defense 5 2010-07-01 2010-07-01 false Purpose and scope. 775.1 Section 775.1 National... IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT § 775.1 Purpose and scope. (a) To implement the...

  15. 27 CFR 479.81 - Scope of tax.


    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Scope of tax. 479.81... OTHER FIREARMS Transfer Tax § 479.81 Scope of tax. Except as otherwise provided in this part, each transfer of a firearm in the United States is subject to a tax to be represented by an adhesive stamp...

  16. 32 CFR 235.2 - Applicability and scope.


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Applicability and scope. 235.2 Section 235.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS SALE OR RENTAL OF SEXUALLY EXPLICIT MATERIAL ON DOD PROPERTY § 235.2 Applicability and scope....

  17. 42 CFR 73.2 - Purpose and scope.


    ... 42 Public Health 1 2010-10-01 2010-10-01 false Purpose and scope. 73.2 Section 73.2 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES QUARANTINE, INSPECTION, LICENSING SELECT AGENTS AND TOXINS § 73.2 Purpose and scope. This part implements the provisions of the Public...

  18. 10 CFR 2.1103 - Scope of subpart K.


    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope of subpart K. 2.1103 Section 2.1103 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Hybrid... § 2.1103 Scope of subpart K. The provisions of this subpart, together with subpart C and...

  19. 10 CFR 431.191 - Purpose and scope.


    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 431.191 Section 431.191 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Distribution Transformers § 431.191 Purpose and scope. This subpart contains energy conservation requirements for distribution...

  20. 43 CFR 4.800 - Scope and construction of rules.


    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Scope and construction of rules. 4.800... of the Department of the Interior-Effectuation of Title VI of the Civil Rights Act of 1964 General § 4.800 Scope and construction of rules. (a) The rules of procedure in this subpart I supplement...

  1. Literacy Teaching Aids from High/Scope Educational Research Foundation

    Science Activities: Classroom Projects and Curriculum Ideas, 2005


    High/Scope's approach to education is a blend of Jean Piaget's constructivist theory of child development and the best of traditional teacher experience. The High/Scope approach is about helping students gain knowledge and skills in important content areas, such as language and literacy, initiative and social relations, movement, music, and…

  2. 42 CFR 405.2411 - Scope of benefits.


    ... 42 Public Health 2 2010-10-01 2010-10-01 false Scope of benefits. 405.2411 Section 405.2411 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... Center Services § 405.2411 Scope of benefits. (a) Rural health clinic services reimbursable under...

  3. 42 CFR 410.3 - Scope of benefits.


    ... 42 Public Health 2 2010-10-01 2010-10-01 false Scope of benefits. 410.3 Section 410.3 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS General Provisions § 410.3 Scope of benefits. (a)...

  4. 26 CFR 521.103 - Scope of the convention.


    ... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Scope of the convention. 521.103 Section 521... UNDER TAX CONVENTIONS DENMARK General Income Tax Taxation of Nonresident Aliens Who Are Residents of Denmark and of Danish Corporations § 521.103 Scope of the convention. (a) The primary purposes of...

  5. 26 CFR 509.103 - Scope of the convention.


    ... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Scope of the convention. 509.103 Section 509... UNDER TAX CONVENTIONS SWITZERLAND General Income Tax § 509.103 Scope of the convention. (a) Purposes of convention. The primary purposes of the convention, to be accomplished on a reciprocal basis, are to...

  6. 39 CFR 3030.2 - Scope and nature of complaints.


    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Scope and nature of complaints. 3030.2 Section 3030.2 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES FOR COMPLAINTS General § 3030.2 Scope and nature of complaints. Any interested person (including a duly appointed officer of...

  7. 30 CFR 206.150 - Purpose and scope.


    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Purpose and scope. 206.150 Section 206.150 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.150 Purpose and scope. (a) This subpart is applicable to all...

  8. 29 CFR 1606.2 - Scope of title VII protection.


    ... 29 Labor 4 2010-07-01 2010-07-01 false Scope of title VII protection. 1606.2 Section 1606.2 Labor... BECAUSE OF NATIONAL ORIGIN § 1606.2 Scope of title VII protection. Title VII of the Civil Rights Act of..., religion, sex or national origin. The title VII principles of disparate treatment and adverse...

  9. 21 CFR 1230.2 - Scope of the act.


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope of the act. 1230.2 Section 1230.2 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS... CAUSTIC POISON ACT General Provisions § 1230.2 Scope of the act. The provisions of the act apply to...

  10. 21 CFR 1210.2 - Scope of act.


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope of act. 1210.2 Section 1210.2 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER... MILK ACT General Provisions § 1210.2 Scope of act. The provisions of the act apply to all milk...

  11. 45 CFR 302.0 - Scope of this part.


    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Scope of this part. 302.0 Section 302.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES STATE PLAN REQUIREMENTS § 302.0 Scope of this...

  12. Radiological Scoping Survey of the Scotia Depot Scotia, New York

    E. N. Bailey


    At the request of the Defense Logistics Agency, the Oak Ridge Institute for Science and Education conducted radiological scoping surveys of the Scotia Depot during the period of September 24 through 27, 2007. The scoping survey included visual inspections and limited radiological surveys performed in accordance with area classification that included surface scans, total and removable activity measurements, and soil sampling.

  13. 46 CFR 53.01-5 - Scope (modifies HG-100).


    ... 46 Shipping 2 2010-10-01 2010-10-01 false Scope (modifies HG-100). 53.01-5 Section 53.01-5... General Requirements § 53.01-5 Scope (modifies HG-100). (a) The regulations in this part apply to steam... IV of the ASME Boiler and Pressure Vessel Code (incorporated by reference; see 46 CFR 53.01-1)....

  14. 41 CFR 105-1.000-50 - Scope of part.


    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope of part. 105-1.000-50 Section 105-1.000-50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION § 105-1.000-50 Scope of...


    Mullarkey, Daniel J.; Bishop, Richard C.


    Wetlands valuation is a situation in which CVM studies might be expected to fail scope tests. This paper reports results from a split-sample CVM study of Wisconsin wetlands. The survey employed a multiple-bounded, polychotomous-choice format, and compared WTP distributions using the method of convolutions. The survey demonstrated sensitivity to scope.

  16. 40 CFR 82.1 - Purpose and scope.


    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Purpose and scope. 82.1 Section 82.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls § 82.1 Purpose and scope. (a) The purpose of the regulations in this subpart is...

  17. 7 CFR 1773.38 - Scope of engagement.


    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Scope of engagement. 1773.38 Section 1773.38 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF... § 1773.38 Scope of engagement. (a) RUS requires that the audit procedures set forth in §§ 1773.39...

  18. 20 CFR 422.601 - Scope and purpose.


    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Scope and purpose. 422.601 Section 422.601 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Administrative Review Process Under the Coal Industry Retiree Health Benefit Act of 1992 § 422.601 Scope and purpose. The...

  19. 7 CFR 215.1 - General purpose and scope.


    ... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 215.1 Section 215.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR CHILDREN § 215.1 General purpose and scope. This part announces the policies...

  20. 10 CFR 820.70 - Purpose and scope.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Purpose and scope. 820.70 Section 820.70 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES Criminal Penalties § 820.70 Purpose and scope... Requirements and the referral of such violations to the Department of Justice....

  1. Upgrade of Daya Bay full scope simulator

    Daya Bay full scope simulator was manufactured by French THOMSON Company in earlier 1990s. It was put into operation in August 1992, one year before the plant's unit-1 was commissioned. During nearly 10 years, the Daya Bay simulator was used to train the control room operators. As many as 220 operators obtained their operator licenses or senior operators licenses. The Daya Bay simulator made a great contribution to the plant's operation. 2) Owing to the limitation of simulation technology and computer capacity in that age, Daya Bay simulator had its deficiencies from the beginning, making maintenance difficult, gradually bringing more and more impact on operator training. - Bad performance: The main computer was the Gould CONCEPT 32/67. Its calculation speed is quite low and memory very limited. Even in the normal operation mode, the average CPU load was up to 80%. The simulation fidelity and scope were not sufficient, which could not meet the deep level of training demand. Many special plant scenarios were not simulated; therefore it was not possible to undertake the verification exercises for the corresponding plant operations. - Poor maintainability: - In hardware aspect, due to that Gould CONCEPT 32/67 is with multi-board architecture. Thousands of tiny connection pins between boards and chasses was the weak link, after many times board plug in-out repair the connection became worse and worse. In addition, the spare parts are difficult to order. Computer crashes happened very often. Each time, the failures each took a few hours, even a few days to fix. - In software aspect, simulation modules suspension, OUT OF TIME error and software breakdown were often occurring. To restart the system took over half an hour each time, which seriously interrupted normal training. - In software maintenance aspect, most modules are manually coded and the development tools are difficult to use. Less than 10% of modifications related to the plant upgrade could be implemented on

  2. A global attentional scope setting prioritizes faces for conscious detection.

    Sun, Sol Z; Cant, Jonathan S; Ferber, Susanne


    The scope of visual attention is known to affect conscious object perception, with recent studies showing that a global attentional scope boosts holistic face processing, relative to a local scope. Here we show that attentional scope settings can also modulate the availability of information for conscious visual awareness. In an initial experiment, we show that adopting a global attentional scope accelerates conscious detection of initially invisible faces, presented under continuous flash suppression (CFS). Furthermore, face detection time was not modulated by attentional scope in a nonrivalrous control condition, which emulated the experience of CFS without inducing binocular rivalry. In a follow-up experiment, we report an exact replication of the original effect, as well as data suggesting that this effect is specific to upright faces, and is abolished when using both inverted faces and images of houses in an otherwise identical task. Thus, attentional scope settings can modulate the availability of information to conscious awareness, fundamentally altering the contents of our subjective visual experience. PMID:27089064

  3. Oral care post stroke: a scoping review.

    Kwok, C; McIntyre, A; Janzen, S; Mays, R; Teasell, R


    Health concerns post stroke may be the result of, or exacerbated by, neglected oral health care (OHC). However, OHC may be challenging post stroke due to hemiparesis, hemiplegia, a lack of coordination, and/or cognitive deficits. The objective of this study was to conduct a scoping review and summarise the current state of knowledge pertaining to OHC post stroke. A literature search was conducted using the multiple databases (MEDLINE, CINAHL, EMBASE, etc.). Combinations of multiple keywords were searched: oral, dental, health, care, hygiene, teeth, dentures, tooth brushing, stroke, cardiovascular health and cardiovascular disease. A grey literature search was also conducted. Articles included were those published in English between 1970 and July 2013, which focused on at least one aspect of OHC among a stroke population. For clinical trials, ≥50% of the sample must have sustained a stroke. In total, 60 articles met inclusion and focused on three primary area: (i) OHC Importance/Stroke Implications; (ii) Current Research; and (iii) Current Practice. It was found that OHC concerns are mainly related to mastication, dysphagia/nutrition, hygiene, prostheses and quality of life. Research indicates that there is limited specialised and individual care provided, and there are few assessment tools, guidelines and established protocols for oral health that are specific to the stroke population. Further, dental professionals' and nurses' knowledge of OHC is generally inadequate; hence, proper education for health professionals in acute and rehabilitation settings, patients, and caregivers has been discussed. PMID:25244419

  4. The Scope of Numeracy after Five Years

    H.L. Vacher


    Full Text Available The purpose of this editorial is to provide an efficient way for readers and potential authors to see (a what type of papers are published in this journal and (b what subjects are appropriate. The editorial consists mainly of about a dozen pages of tables including live links to the papers’ access/abstract pages to facilitate easy browsing. In the first table, the 85 papers that have been published in the journal’s first five years are classified into: review papers; research papers; case studies; essays; book reviews; columns; and editorials about the journal. In the second table, the papers are inventoried into overlapping sets on: assessment; QL and writing; the construct of QL; focused QL courses and curricula; QL across the curriculum; QL centers; algebra and calculus education; statistics education; intersections with science and engineering; intersections with social sciences; financial numeracy; health numeracy; math anxiety; and cognition. Browsing these links confirms what we said in the first editorial: the scope of Numeracy is huge.

  5. Some scoping experiments for a space reactor

    Some scoping experiments were performed to evaluate fuel performance in a lithium heat pipe reactor operating at a nominal 1500K heat pipe temperature. Fuel-coolant and fuel-coolant-clad relationships showed that once a failed heat pipe occurs temperatures can rise high enough so that large concentrations of uranium can be transported by the vapor phase. Upon condensation this uranium would be capable of penetrating heat pipes adjacent to the failed pipe. The potential for propagation of failure exists with UO2 and a lithium heat pipe. Changing the composition of the metal of the heat pipe would have only a second order effect on the kinetics of the failure mechanism. Uranium carbide and nitride were considered as potential fuels which are nonreactive in a lithium environment. At high temperatures the nitride would be favored because of its better compatibility with potential cladding materials. Compositions of UN with small additions of YN appear to offer very attractive properties for a compact high temperature high power density reactor

  6. Cementitious waste option scoping study report

    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored as a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period

  7. Cementitious waste option scoping study report

    Lee, A.E.; Taylor, D.D.


    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored as a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period.

  8. Magnetotactic bacteria and magnetosomes - Scope and challenges.

    Jacob, Jobin John; Suthindhiran, K


    Geomagnetism aided navigation has been demonstrated by certain organisms which allows them to identify a particular location using magnetic field. This attractive technique to recognize the course was earlier exhibited in numerous animals, for example, birds, insects, reptiles, fishes and mammals. Magnetotactic bacteria (MTB) are one of the best examples for magnetoreception among microorganisms as the magnetic mineral functions as an internal magnet and aid the microbe to move towards the water columns in an oxic-anoxic interface (OAI). The ability of MTB to biomineralize the magnetic particles (magnetosomes) into uniform nano-sized, highly crystalline structure with uniform magnetic properties has made the bacteria an important topic of research. The superior properties of magnetosomes over chemically synthesized magnetic nanoparticles made it an attractive candidate for potential applications in microbiology, biophysics, biochemistry, nanotechnology and biomedicine. In this review article, the scope of MTB, magnetosomes and its challenges in research and industrial application have been discussed in brief. This article mainly focuses on the application based on the magnetotactic behaviour of MTB and magnetosomes in different areas of modern science. PMID:27524094

  9. The international scope of IAEA safeguards

    As a result of safeguards agreements under the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and with States not Party to that Treaty, the Agency's safeguards coverage today is very extensive. According to the best information officially available to the Agency, there are only five States in the world besides the nuclear-weapon States that have significant nuclear activities which are not subject to Agency safeguards, namely Egypt, India, Israel, South Africa and Spain. Nevertheless, any State that is not a Party to the NPT or the Treaty for the Prohibition of Nuclear Weapons in Latin America (Tlatelolco Treaty) is free, in the absence of treaty obligations, to build or otherwise acquire unsafeguarded nuclear plant. Furthermore, there are significant differences between the NPT safeguards agreements and those with States not Party to the NPT, not only with regard to scope (NPT agreements cover all peaceful nuclear activities in the State, which in practice means all nuclear activities, while non-NPT agreements so far only cover particular plants or supply agreements) but also in technical and legal approach (NPT agreements reflect important advances in safeguards concepts indicated in the Treaty itself). (author)

  10. AuScope VLBI Project and Hobart 26-m Antenna

    Lovell, Jim; Dickey, John; Reid, Brett; McCallum, Jamie; Shabala, Stas; Watson, Christopher; Ellingsen, Simon; Memin, Anthony


    This is a report on the activities carried out at the three AuScope VLBI observatories and the Hobart 26-m antenna. In 2012 the three AuScope 12-m antennas at Hobart (Hb), Katherine (Ke), and Yarragadee (Yg) completed their first full year of operations as an array. The Hobart 26-m antenna (Ho) continued to make a contribution to IVS, providing overlap with the Hb time series. In total the AuScope antennas and the Hobart 26 m observed for 146 antenna days in 2012. In this report we also briefly highlight our research activities during 2012 and our plans for 2013.

  11. Scope of Collections Statement Ohio River Islands National Wildlife Refuge

    US Fish and Wildlife Service, Department of the Interior — This Scope of Collections Statement serves to define the holdings, present and future, of museum property that contributes directly to the mission of Ohio River...

  12. 31 CFR 29.301 - Purpose and scope.


    ... determination and review of eligibility and payments, and financial management, are beyond the scope of this... illustrative examples of sample computations to show the application of the general principles to...

  13. 40 CFR 255.1 - Scope and purpose.


    ... types (residential and commercial solid waste, hazardous wastes, industrial sludges and pretreatment... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT General Provisions § 255.1 Scope and purpose. (a)...

  14. 12 CFR 216.1 - Purpose and scope.


    ... CONSUMER FINANCIAL INFORMATION (REGULATION P) § 216.1 Purpose and scope. (a) Purpose. This part governs the... who obtain financial products or services primarily for personal, family, or household purposes...

  15. 12 CFR 716.1 - Purpose and scope.


    ... CONSUMER FINANCIAL INFORMATION § 716.1 Purpose and scope. (a) Purpose. This part governs the treatment of... services for personal, family or household purposes. This part does not apply to information...

  16. 12 CFR 332.1 - Purpose and scope.


    ... OF CONSUMER FINANCIAL INFORMATION § 332.1 Purpose and scope. (a) Purpose. This part governs the... who obtain financial products or services primarily for personal, family, or household purposes...

  17. Economies of scope in Danish primary care practices

    Kristensen, Troels; Rose Olsen, Kim


    Aim: We analyze total operating costs and activities in Danish General Practice units to assess whether there are unexploited economies of scope in the production of primary care services. Methods: We apply stochastic frontier analysis to derive cost functions and associated cost complementarities...... between GP services and overall economies of scope. Data: Cross-section data for a sample of 331 primary care practices with 1-8 GPs from the year 2006. This is a unique combined dataset consisting of survey and register data. Results: We find a trend towards cost complementarities between the production...... positive economies of scope in the production of GP services. Conclusions: Our preliminary results show that there were overall economies of scope associated with the joint production of a) standard consultations, b) email/phone consultations and c) home visits. Cost complementarities between standard...

  18. 45 CFR 170.400 - Basis and scope.


    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION... FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT § 170.400 Basis and scope... and procedures related to the temporary certification program for health information...

  19. 30 CFR 881.1 - Purpose and scope.


    ... LAND RECLAMATION SUBSIDENCE AND STRIP MINE REHABILITATION, APPALACHIA § 881.1 Purpose and scope. The... rehabilitation of existing strip and surface mine areas under the authority of subsection (a)(1) of section...

  20. 5 CFR 179.301 - Scope of regulations.


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Scope of regulations. 179.301 Section 179.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS... in 4 CFR 102.3....

  1. 28 CFR 551.20 - Purpose and scope.


    ... Birth Control, Pregnancy, Child Placement, and Abortion § 551.20 Purpose and scope. The Bureau of Prisons provides an inmate with medical and social services related to birth control, pregnancy,...

  2. 32 CFR 320.1 - Purpose and scope.


    ... NATIONAL GEOSPATIAL-INTELLIGENCE AGENCY (NGA) PRIVACY § 320.1 Purpose and scope. (a) This part is published... whether the National Geospatial-Intelligence Agency (NGA) maintains or has disclosed a record...

  3. 78 FR 36748 - Caribbean Fishery Management Council; Scoping Meetings

    2013-06-19 , or the Council office at (787) 766-5926 to obtain copies. Written comments can be sent to... . The scoping meetings will be held on the following dates and locations: In...

  4. 48 CFR 750.7100 - Scope of subpart.


    ... MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS Extraordinary Contractual Actions To Protect Foreign Policy Interests of the United States 750.7100 Scope of subpart. This subpart sets forth the standards and...

  5. 48 CFR 10.000 - Scope of part.


    ... MARKET RESEARCH 10.000 Scope of part. This part prescribes policies and procedures for conducting market research to arrive at the most suitable approach to acquiring, distributing, and supporting supplies...

  6. 12 CFR 715.1 - Scope of this part.


    ... of the Supervisory Committee to obtain an annual audit of the credit union according to its charter... COMMITTEE AUDITS AND VERIFICATIONS § 715.1 Scope of this part. This part implements section 202(a)(6)(D)...

  7. 49 CFR 178.700 - Purpose, scope and definitions.


    ... PACKAGINGS IBC Performance-Oriented Standards § 178.700 Purpose, scope and definitions. (a) This subpart... pertain to the IBC standards in this subpart. (1) Body means the receptacle proper (including openings...

  8. 48 CFR 4.500 - Scope of subpart.


    ... MATTERS Electronic Commerce in Contracting 4.500 Scope of subpart. This subpart provides policy and procedures for the establishment and use of electronic commerce in Federal acquisition as required by...

  9. 48 CFR 2917.500 - Scope of subpart.


    ... CONTRACT TYPES SPECIAL CONTRACTING METHODS Interagency Acquisitions Under The Economy Act 2917.500 Scope of... of interagency acquisitions under the Economy Act (31 U.S.C. 1535) as prescribed by FAR 17.5....

  10. 30 CFR 5.10 - Purpose and scope.


    ... MINING PRODUCTS FEES FOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS § 5.10 Purpose and scope... control and security and document preparation directly supporting application processing; (3)...

  11. Scoping accident(s) for emergency planning

    At the request of the Conference of State Radiation Control Program Director's (CRCPD), in November 1976 the U.S. Nuclear Regulatory Commission formed a joint Task Force with representatives of the U.S. Environmental Protection Agency to answer a number of questions posed by the States regarding emergency planning. This Task Force held monthly meetings through November 1977. In December 1977 a draft report was prepared for limited distribution for review and comment by selected State and local organizations. The NRC/EPA Task Force deliberations centered on the CRCPD request for '... a determination of the most severe accident basis for which radiological emergency response plans should be developed by offsite agencies...' in the vicinity of nuclear power plants. Federal Interagency guidance to the States in this regard has been that the scoping accident should be the most serious conservatively analyzed accident considered for siting purposes, as exemplified in the Commission's Regulations at 10 CFR Part 100 and the NRC staffs Regulatory Guides 1.3 and 1.4, and as presented in license applicant's Safety Analysis Reports and the USNRC Staffs Safety Evaluation Reports. The draft report of the Task Force amplifies on this recommendation: to present a clearer picture of its import and introduces the concept of protective action zones (PAZs) within which detailed emergency plans should be developed; one zone for the plume exposure pathway and a second, larger zone for contamination pathways. The time dependence of potential releases and atmospheric transport, and important radionuclide groups of possible import are also discussed in the draft Task Force report. A status report regarding this effort, as of June 1978, will be presented. (author)

  12. Automated diagnostics scoping study. Final report

    Quadrel, R.W.; Lash, T.A.


    The objective of the Automated Diagnostics Scoping Study was to investigate the needs for diagnostics in building operation and to examine some of the current technologies in automated diagnostics that can address these needs. The study was conducted in two parts. In the needs analysis, the authors interviewed facility managers and engineers at five building sites. In the technology survey, they collected published information on automated diagnostic technologies in commercial and military applications as well as on technologies currently under research. The following describe key areas that the authors identify for the research, development, and deployment of automated diagnostic technologies: tools and techniques to aid diagnosis during building commissioning, especially those that address issues arising from integrating building systems and diagnosing multiple simultaneous faults; technologies to aid diagnosis for systems and components that are unmonitored or unalarmed; automated capabilities to assist cause-and-effect exploration during diagnosis; inexpensive, reliable sensors, especially those that expand the current range of sensory input; technologies that aid predictive diagnosis through trend analysis; integration of simulation and optimization tools with building automation systems to optimize control strategies and energy performance; integration of diagnostic, control, and preventive maintenance technologies. By relating existing technologies to perceived and actual needs, the authors reached some conclusions about the opportunities for automated diagnostics in building operation. Some of a building operator`s needs can be satisfied by off-the-shelf hardware and software. Other needs are not so easily satisfied, suggesting directions for future research. Their conclusions and suggestions are offered in the final section of this study.

  13. 10 CFR 715.1 - Purpose and scope.


    ... production facility,” in section 416(a)(2)(B) of the Clean Air Act Amendments of 1990, 42 U.S.C. 7651o(a)(2... 10 Energy 4 2010-01-01 2010-01-01 false Purpose and scope. 715.1 Section 715.1 Energy DEPARTMENT OF ENERGY DEFINITION OF NON-RECOURSE PROJECT-FINANCED § 715.1 Purpose and scope. This part sets...

  14. Full scope simulator commissioning and training experience at Cernavoda NPP

    The paper presents the experience gained during commissioning and the initial use of the CANDU training full-scope simulator for operation personnel at Cernavoda NPP. The full-scope simulator as an integral part of the training programs that take place in Cernavoda Nuclear Training Department (CNTD), is mainly used for the development of operational skills, knowledge and attitudes required to operate the plant in a safe and efficient manner. (author)


    Kupar, J; Sadika Baladi, S; Mark Amidon, M


    This scoping summary supports development of the combined Remedial Investigation (RI)/Baseline Risk Assessment (BRA)/Feasibility Study (FS) for the P-Area Operable Unit (PAOU), or Combined document, which will be submitted on or before 09/28/2007. The objective of this Feasibility Study scoping summary meeting is to agree on the likely response actions to be evaluated and developed as alternatives in the combined document and agree on the uncertainties identified and whether they have been adequately managed.


    This scoping summary supports development of the combined Remedial Investigation (RI)/Baseline Risk Assessment (BRA)/Feasibility Study (FS) for the P-Area Operable Unit (PAOU), or Combined document, which will be submitted on or before 09/28/2007. The objective of this Feasibility Study scoping summary meeting is to agree on the likely response actions to be evaluated and developed as alternatives in the combined document and agree on the uncertainties identified and whether they have been adequately managed

  17. Comorbidity and dementia: a scoping review of the literature

    Bunn, F; Burn, A-M; Goodman, C; Rait, G.; Norton, S.; Robinson, L.; J Schoeman; Brayne, C


    Background Evidence suggests that amongst people with dementia there is a high prevalence of comorbid medical conditions and related complaints. The presence of dementia may complicate clinical care for other conditions and undermine a patient’s ability to manage a chronic condition. The aim of this study was to scope the extent, range and nature of research activity around dementia and comorbidity. Methods We undertook a scoping review including all types of research relating to the prevalen...

  18. Scoping review of patient-centered care approaches in healthcare

    Constand, Marissa K; MacDermid, Joy C; Dal Bello-Haas, Vanina; Law, Mary


    Background The purpose of this scoping review was to describe how three tenants of patient-centered care provision: communication, partnership, and health promotion are addressed in patient-centered care models/frameworks across the literature. Methods A scoping review of literature published in English since 1990 was conducted using Medline, CINAHL, and EMBASE. A key term search strategy was employed using “patient-centered care”, “client-centered care”, “framework” and “model” to identify r...

  19. De betekenis van marktstructuren voor de scope van de onderneming

    Commandeur, Harry


    textabstractDifferent market structures and value systems give insight into the changing environment in which companies operate. In this inaugural address the central question is: What is the influence of market structures on the scope of the firm?The objective is to give meaningful contributions to the clear understanding of market structures that are of specific importance at the meso level. To gain more insights into the scope of the firm a framework is constructed based on the three dimen...

  20. Demand Responsive Lighting: A Scoping Study

    Rubinstein, Francis; Kiliccote, Sila


    The objective of this scoping study is: (1) to identify current market drivers and technology trends that can improve the demand responsiveness of commercial building lighting systems and (2) to quantify the energy, demand and environmental benefits of implementing lighting demand response and energy-saving controls strategies Statewide. Lighting systems in California commercial buildings consume 30 GWh. Lighting systems in commercial buildings often waste energy and unnecessarily stress the electrical grid because lighting controls, especially dimming, are not widely used. But dimmable lighting equipment, especially the dimming ballast, costs more than non-dimming lighting and is expensive to retrofit into existing buildings because of the cost of adding control wiring. Advances in lighting industry capabilities coupled with the pervasiveness of the Internet and wireless technologies have led to new opportunities to realize significant energy saving and reliable demand reduction using intelligent lighting controls. Manufacturers are starting to produce electronic equipment--lighting-application specific controllers (LAS controllers)--that are wirelessly accessible and can control dimmable or multilevel lighting systems obeying different industry-accepted protocols. Some companies make controllers that are inexpensive to install in existing buildings and allow the power consumed by bi-level lighting circuits to be selectively reduced during demand response curtailments. By intelligently limiting the demand from bi-level lighting in California commercial buildings, the utilities would now have an enormous 1 GW demand shed capability at hand. By adding occupancy and light sensors to the remotely controllable lighting circuits, automatic controls could harvest an additional 1 BkWh/yr savings above and beyond the savings that have already been achieved. The lighting industry's adoption of DALI as the principal wired digital control protocol for dimming ballasts

  1. Automated scoping methodology for liquid metal natural circulation small reactor

    Highlights: • Automated scoping methodology for natural circulation small modular reactor is developed. • In-house code is developed to carry out system analysis and core geometry generation during scoping. • Adjustment relations are obtained to correct the critical core geometry out of diffusion theory. • Optimized design specification is found using objective function value. • Convex hull volume is utilized to quantify the impact of different constraints on the scope range. - Abstract: A novel scoping method is proposed that can automatically generate design variable range of the natural circulation driven liquid metal cooled small reactor. From performance requirements based upon Generation IV system roadmap, appropriate structure materials are selected and engineering constraints are compiled based upon literature. Utilizing ASME codes and standards, appropriate geometric sizing criteria on constituting components are developed to ensure integrity of the system during its lifetime. In-house one dimensional thermo-hydraulic system analysis code is developed based upon momentum integral model and finite element methods to deal with non-uniform descritization of temperature nodes for convection and thermal diffusion equation of liquid metal coolant. In order to quickly generate critical core dimensions out of given unit cell information, an adjustment relation that relates the critical geometry estimated from one-group diffusion and that from MCNP code is constructed and utilized throughout the process. For the selected unit cell dimension ranges, burnup calculations are carried out to check the cores can generate energy over the reactor lifetime. Utilizing random method, sizing criteria, and in-house analysis codes, an automated scoping methodology is developed. The methodology is applied to nitride fueled integral type lead cooled natural circulation reactor concept to generate design scopes which satisfies given constraints. Three dimensional convex

  2. USArray Siting Outreach: Telling the EarthScope Story

    Dorr, P. M.; Taber, J. J.; McQuillan, P.; Busby, R. W.; Woodward, R.


    USArray has engaged in a variety of activities that involve students in and inform the general public about EarthScope. Examples include the highly successful Transportable Array Student Siting Program that employed students and faculty from colleges and universities in the identification of sites for future Transportable Array stations in their region, and a range of informal education and media opportunities where information about EarthScope and its discoveries are shared with educators and the public. During the course of eight summers, more than 135 students from about 55 institutions conducted site reconnaissance for nearly 1375 sites from the West Coast to the East Coast, and from the Gulf of Mexico to the Great Lakes and southern Canada. While telling the EarthScope story, students who participated in the program increased their professional skills and deepened their personal growth. Other students had opportunities to engage in EarthScope-related research as part of the Research Experiences for Undergraduates program. Several EarthScope-focused outreach products for the public and educational audiences have been developed including Ground Motion Visualizations, EarthScope-centric and regional content sets for the IRIS Active Earth Monitor (AEM), and animations of earth processes. A kiosk loan program has helped to broadly disseminate the AEM displays. There have also been articles published in university, local and regional newspapers; stories appearing in national and international print and broadcast media; and documentaries produced by some of the world's most respected scientific and educational production companies that have included a segment about EarthScope and the Transportable Array. Over the next five years, USArray will be deploying and operating Transportable Array stations in Alaska and western Canada. This challenging environment will offer new opportunities to connect with communities throughout the region including native populations.

  3. Visualizing Data from EarthScope's USArray

    Woodward, R.; Frassetto, A.; Adinolfi, A.


    The EarthScope USArray program has generated a large volume of data from across the North American continent. The Transportable Array (TA) component of USArray has deployed over 400 seismic stations in a grid with 70 km spacing between stations. The TA has rolled the array across the contiguous US states over a ten-year period, and will have occupied over 1600 distinct sites from the Pacific Ocean to the Atlantic Ocean by the end of 2013. All stations transmit multiple channels of 40 samples per second data continuously, in near real time. Each station records and transmits seismic, barometric pressure, and infrasound data, as well as various state-of-health data streams. All data are immediately open and unrestricted. The TA provides a unique tool for visualizing large-scale seismic wave phenomena. The power of this tool is particularly apparent when displaying simultaneous signals from all stations as a function of time, as well as rendering multiple channels of data from each station. In this situation it is challenging to convey the 3D motion at each station as well as the aggregate 3D motion across the entire set of 400 stations. Creating movies of the data becomes essential to illustrate the time dependence of the observations. Typically the rendering of such movies requires the use of programming language that is suitable for both data analysis and graphics, as it is essential to explore different data pre-processing strategies (often filtering, but also including other pre-processing steps). Different visualization strategies provide a means for dealing with the very large volume of data generated by the TA. Typical data review strategies include a survey mode to scan large volumes of data for signals of interest, or zooming in on fine features using combinations of specialized data processing and frame-by-frame time-steps, or going back and forth between the two modes. The data visualizations are continuously evolving to explore new ideas. The movie

  4. Evaluation of full-scope simulator testing methods

    This report discusses the use of full scope nuclear power plant simulators in licensing examinations for Unit First Operators of CANDU reactors. The existing literature is reviewed, and an annotated bibliography of the more important sources provided. Since existing methods are judged inadequate, conceptual bases for designing a system for licensing are discussed, and a method proposed which would make use of objective scoring methods based on data collection in full-scope simulators. A field trial of such a method is described. The practicality of such a method is critically discussed and possible advantages of subjective methods of evaluation considered. (author). 32 refs., 1 tab., 4 figs

  5. 22 CFR 194.1 - Authority and scope of application.


    ... Section 194.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION INTER-AMERICAN COMMERCIAL ARBITRATION COMMISSION RULES OF PROCEDURE § 194.1 Authority and scope of application. In... State has determined that the amended Rules of Procedures of the Inter-American Commercial...

  6. 12 CFR 219.21 - Authority, purpose and scope.


    ... Authority, purpose and scope. This subpart of Regulation S (12 CFR part 219, subpart B) is issued by the... amended by the Annunzio-Wylie Anti-Money Laundering Act of 1992 (Pub. L. 102-550, Title XV; 106 Stat. 3672... promulgated and administered jointly by the Board and the Treasury and are codified in 31 CFR 103.11 and...

  7. 20 CFR 410.401 - Scope of subpart D.


    ...-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.401 Scope of subpart... totally disabled due to pneumoconiosis, whether he was totally disabled due to pneumoconiosis at the time of his death, or whether his death was due to pneumoconiosis. (b) Pneumoconiosis...

  8. 28 CFR 543.10 - Purpose and scope.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 543.10 Section 543.10 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS... shall establish an inmate law library, and procedures for access to legal reference materials and...

  9. 13 CFR 303.1 - Purpose and scope.


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Purpose and scope. 303.1 Section 303.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE...-term Planning Investments and State plans designed to create and retain higher-skill, higher-wage...

  10. 34 CFR 682.700 - Purpose and scope.


    ... basis of handicap), which is governed by 34 CFR part 104; or (iv) Title IX of the Education Amendments of 1972 (relating to sex discrimination), which is governed by 34 CFR part 106. (c) This subpart does... 34 Education 3 2010-07-01 2010-07-01 false Purpose and scope. 682.700 Section 682.700...