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Sample records for 3p cu 3s

  1. Intercombination decay of 3s3p3P10 in Mg I-like Ni and Cu

    The intercombination transition 3s21S0-3s3p 3p10 in Ni16+ and Cu17+ has been studied by beam-foil spectroscopic methods. Decay curve analysis yields lifetime values of (12.0+-1.0) ns and (8.8+-0.6) ns for Ni and Cu in agreement with various predictions. (orig./WL)

  2. A study of angle-resolved photoemission extended fine structure as applied to the Ni 3p, Cu 3s, and Cu 3p core levels of the respective clean (111) surfaces

    Huff, W.R.A.; Moler, E.J.; Kellar, S.A. [Lawrence Berkeley National Lab., CA (United States)] [and others

    1997-04-01

    The first non-s initial state angle-resolved photoemission extended fine structure (ARPEFS) study of clean surfaces for the purpose of further understanding the technique is reported. The surface structure sensitivity of ARPEFS applied to clean surfaces and to arbitrary initial states is studied using normal photoemission data taken from the Ni 3p core levels of a Ni(111) single crystal and the Cu 3s and the Cu 3p core-levels of a Cu(111) single crystal. The Fourier transforms of these clean surface data are dominated by backscattering. Unlike the s initial state data, the p initial state data show a peak in the Fourier transform corresponding to in-plane scattering from the six nearest-neighbors to the emitter. Evidence was seen for single-scattering events from in the same plane as the emitters and double-scattering events. Using a newly developed, multiple-scattering calculation program, ARPEFS data from clean surfaces and from p initial states can be modeled to high precision. Although there are many layers of emitters when measuring photoemission from a clean surface, test calculations show that the ARPEFS signal is dominated by photoemission from atoms in the first two crystal layers. Thus, ARPEFS applied to clean surfaces is sensitive to surface reconstruction. The known contraction of the first two Cu(111) layers is confirmed. The best-fit calculation for clean Ni(111) indicates an expansion of the first two layers. To better understand the ARPEFS technique, the authors studied s and non-s initial state photoemission from clean metal surfaces.

  3. A study of angle-resolved photoemission extended fine structure as applied to the Ni 3p, Cu 3s, and Cu 3p core levels of the respective clean (111) surfaces

    The first non-s initial state angle-resolved photoemission extended fine structure (ARPEFS) study of clean surfaces for the purpose of further understanding the technique is reported. The surface structure sensitivity of ARPEFS applied to clean surfaces and to arbitrary initial states is studied using normal photoemission data taken from the Ni 3p core levels of a Ni(111) single crystal and the Cu 3s and the Cu 3p core-levels of a Cu(111) single crystal. The Fourier transforms of these clean surface data are dominated by backscattering. Unlike the s initial state data, the p initial state data show a peak in the Fourier transform corresponding to in-plane scattering from the six nearest-neighbors to the emitter. Evidence was seen for single-scattering events from in the same plane as the emitters and double-scattering events. Using a newly developed, multiple-scattering calculation program, ARPEFS data from clean surfaces and from p initial states can be modeled to high precision. Although there are many layers of emitters when measuring photoemission from a clean surface, test calculations show that the ARPEFS signal is dominated by photoemission from atoms in the first two crystal layers. Thus, ARPEFS applied to clean surfaces is sensitive to surface reconstruction. The known contraction of the first two Cu(111) layers is confirmed. The best-fit calculation for clean Ni(111) indicates an expansion of the first two layers. To better understand the ARPEFS technique, the authors studied s and non-s initial state photoemission from clean metal surfaces

  4. Relativistic calculations of 3s21S0-3s3p 1P1 and 3s21S0-3s3p 3P1,2 transition probabilities in the Mg isoelectronic sequence

    Using the multi-configuration Dirac—Fock self-consistent field method and the relativistic configuration-interaction method, calculations of transition energies, oscillator strengths and rates are performed for the 3s21S0-3s3p 1P1 spin-allowed transition, 3s21S0-3s3p 3P1,2 intercombination and magnetic quadrupole transition in the Mg isoelectronic sequence (Mg I, Al II, Si III, P IV and S V). Electron correlations are treated adequately, including intravalence electron correlations. The influence of the Breit interaction on oscillator strengths and transition energies are investigated. Quantum electrodynamics corrections are added as corrections. The calculation results are found to be in good agreement with the experimental data and other theoretical calculations. (atomic and molecular physics)

  5. Size-tunable, hexagonal plate-like Cu3P and Janus-like Cu-Cu3P nanocrystals.

    De Trizio, Luca; Figuerola, Albert; Manna, Liberato; Genovese, Alessandro; George, Chandramohan; Brescia, Rosaria; Saghi, Zineb; Simonutti, Roberto; Van Huis, Marijn; Falqui, Andrea

    2012-01-24

    We describe two synthesis approaches to colloidal Cu(3)P nanocrystals using trioctylphosphine (TOP) as phosphorus precursor. One approach is based on the homogeneous nucleation of small Cu(3)P nanocrystals with hexagonal plate-like morphology and with sizes that can be tuned from 5 to 50 nm depending on the reaction time. In the other approach, metallic Cu nanocrystals are nucleated first and then they are progressively phosphorized to Cu(3)P. In this case, intermediate Janus-like dimeric nanoparticles can be isolated, which are made of two domains of different materials, Cu and Cu(3)P, sharing a flat epitaxial interface. The Janus-like nanoparticles can be transformed back to single-crystalline copper particles if they are annealed at high temperature under high vacuum conditions, which makes them an interesting source of phosphorus. The features of the Cu-Cu(3)P Janus-like nanoparticles are compared with those of the striped microstructure discovered more than two decades ago in the rapidly quenched Cu-Cu(3)P eutectic of the Cu-P alloy, suggesting that other alloy/eutectic systems that display similar behavior might give origin to nanostructures with flat, epitaxial interface between domains of two diverse materials. Finally, the electrochemical properties of the copper phosphide plates are studied, and they are found to be capable of undergoing lithiation/delithiation through a displacement reaction, while the Janus-like Cu-Cu(3)P particles do not display an electrochemical behavior that would make them suitable for applications in batteries. PMID:22136519

  6. KⅧ-TbLⅣ离子3s3p 3P1-3s2 1S0 的自旋禁戒跃迁%Intercombination Transitions 3s3p 3P1-3s2 1S0 in Magnesium-like Ions through KⅧ to TbLⅣ

    牟致栋; 魏琦瑛

    2004-01-01

    在对KⅧ-TbLⅣ离子3s3p 3P1能级结构的多组态相互作用理论HXR方法计算的基础上, 分析了各种效应对等电子序列离子能级结构的影响, 找出了能级沿等电子序列变化的规律性. 预测计算了K Ⅷ-Tb LⅣ离子3s3p 3P1的能级. 由此进一步计算了KⅧ-TbL Ⅳ离子自旋禁戒跃迁3s3p 3P1-3s2 1S0的谱线波长、振子强度和跃迁概率.

  7. Synthesization of the Ar VIII 3s-3p beam-foil decay curve

    The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

  8. Transition probabilities for the 3s2 3p(2P0)-3s3p2(4P) intersystem lines of Si II

    Calamai, Anthony G.; Smith, Peter L.; Bergeson, S. D.

    1993-01-01

    Intensity ratios of lines of the spin-changing 'intersystem' multiplet of S II (4P yields 2P0) at 234 nm have been used to determine electron densities and temperatures in a variety of astrophysical environments. However, the accuracy of these diagnostic calculations have been limited by uncertainties associated with the available atomic data. We report the first laboratory measurement, using an ion-trapping technique, of the radiative lifetimes of the three metastable levels of the 3s3p2 4P term of Si II. Our results are 104 +/- 16, 406 +/- 33, and 811 +/- 77 micro-s for lifetimes of the J = 1/2, 5/2, and 3/2 levels, respectively. A-values were derived from our lifetimes by use of measured branching fractions. Our A-values, which differ from calculated values by 30 percent or more, should give better agreement between modeled and observed Si II line ratios.

  9. Au Nanowire-Striped Cu3P Platelet Photoelectrocatalysts.

    Dutta, Anirban; Samantara, Aneeya K; Adhikari, Samrat Das; Jena, Bikash Kumar; Pradhan, Narayan

    2016-03-17

    A stripy pattern of continuous epitaxial growth of thin Au nanowires on plasmonic Cu3P platelets is reported. The obtained Au-Cu3P heterostructures retain their wide area interfacial heterojunction, which is typically not observed in metal-semiconductor heterostructures. This is performed by phosphine-mediated in situ reduction of Au ions on specific facets of Cu3P platelets. The intriguing stripy movements of nanowires are regulated by strong surface binding ligands. Because this is a dual plasmon heterostructure with wide visible absorption window, these are further explored as a photoelectrocatalyst for efficient hole transfer and sensing of an important biomolecule, nicotinamide adenine dinucleotide (NADH). The observed anodic photocurrent was 30 times higher in the presence of NADH, and this proves that the heterostructured material is an ideal photosenser and an efficient catalyst for solar energy conversion. PMID:26938025

  10. Relativistic calculations of 3s2 1S0-3s3p 1P1 and 3s2 1S0-3s3p 3P1,2 transition probabilities in the Mg isoelectronic sequence

    Cheng Cheng; Gao Xiang; Qing Bo; Zhang Xiao-Le; Li Jia-Ming

    2011-01-01

    Using the multi-configuration Dirac-Fock self-consistent field method and the relativistic configuration-interaction method, calculations of transition energies, oscillator strengths and rates are performed for the 3s2 1S0-3s3p 1P1 spinallowed transition, 3s2 1S0-3s3p 3P1,2 intercombination and magnetic quadrupole transition in the Mg isoelectronic sequence (Mg Ⅰ, Al Ⅱ, Si ⅢⅢ, P Ⅳ and S Ⅴ). Electron correlations are treated adequately, including intravalence electron correlations. The influence of the Breit interaction on oscillator strengths and transition energies are investigated. Quantum electrodynamics corrections are added as corrections. The calculation results are found to be in good agreement with the experimental data and other theoretical calculations.

  11. Radiative rates for E1, E2, M1, and M2 transitions among the 3s$^2$3p$^5$, 3s3p$^6$, and 3s$^2$3p$^4$3d configurations of Cl-like W LVIII

    Aggarwal, K M

    2014-01-01

    We report calculations of energy levels, radiative decay rates, and lifetimes for transitions among the 3s$^2$3p$^5$, 3s3p$^6$, and 3s$^2$3p$^4$3d configurations of Cl-like W LVIII. The general-purpose relativistic atomic structure package (GRASP) has been adopted for our calculations. Comparisons are made with the most recent results of Mohan et al. [Can. J. Phys. {\\bf 92} (2014) xxx] and discrepancies in lifetimes are noted, up to four orders of magnitude in some instances. Our energy levels are estimated to be accurate to better than 0.5\\%, whereas results for radiative rates and lifetimes should be accurate to better than 20\\%.

  12. 类硅铑离子的3s23p23P1,2-3s3p35S2的跃迁谱线%The Intercombination Lines of 3s23p23P1,2-3s3p35S2 in Si-like Ions, Rhodium

    2002-01-01

    用束箔法研究了类硅铑离子的3s23p23P1,2-3s3p35S2的禁戒跃迁谱线.谱线识别从已知基态精细结构的分裂、基于分支比的强度比、相似的衰减特性、离子束能量下的谱线预期值方面着手.识别后,通过对已知谱线的波长的等电子系列曲线插值或外推来获得用于较刻的谱线的波长,然后较刻出3s23p23P1,2-3s3p35S2这两条谱线.

  13. Electron Excitation Cross Sections for the S II Transitions: 3s(exp 2)3p(exp 3) 4S(exp o) approaches 3s(exp 2)3p(exp 3) 2D(exp o), 2P(exp o), and 3s3p(exp 4) 4P

    Liao, C.; Chutjian, A.; Hitz, D.; Tayal, S. S.

    1997-01-01

    Experimental and theoretical collisional excitation cross sections are reported for the transitions 3s(exp 2)3p(exp 3)4S(exp o) approaches 3s(exp 2)3p(exp 3) 2D(exp o), 2P(exp o), and 3s3P(exp 4) 4P in S II. The transition wavelengths (energies) are 6716 A (1.85 eV), 4069 A (3.05 eV), and 1256 A (9.87 eV), respectively. In the experiments, use is made of the energy-loss merged-beams method. The metastable fraction of the S II beam was assessed and minimized. The contribution of elastically scattered electrons was reduced by the use of a lowered solenoidal magnetic field and a modulated radio-frequency voltage on the analyzing plates and by retarding grids to reject the elastically scattered electrons with larger Larmor radii. For each transition, comparisons are made among experiments, the new 19 state R-matrix calculation, and three other close-coupling calculations.

  14. The Cu2FeTi3S8 and Cu2FeZr3S8 compounds: Crystal structure and electroanalytical application

    The Cu2FeTi3S8 and Cu2FeZr3S8 compounds were produced by solid-state synthesis. The crystal structure of the quaternary phases was investigated by X-ray powder method. The compounds are described in the thiospinel structure (space group Fd3-bar m) with the unit cell parameters a = 1.00099(1) nm (Cu2FeTi3S8) and a = 1.03837(2) nm (Cu2FeZr3S8). The atomic parameters were calculated in the isotropic approximation (RI = 0.0496 and RI = 0.0422 for Cu2FeTi3S8 and Cu2FeZr3S8, respectively). Iron(III)-selective electrodes were prepared using the chalcogenide compounds Cu2FeTi3S8 and Cu2FeZr3S8. The electrode function slopes are 52.7 mV/pC for Cu2FeTi3S8 and 66.2 mV/pC for Cu2FeZr3S8, the detection limits are 1 x 10-5 M and 2 x 10-5 M respectively. The prepared electrochemical sensors are not sensitive to Cd2+, Zn2+, Mn2+, Ni2+, Co2+, Mg2+, Cr3+, and Fe2+ ions, and were tested in the potentiometric titration of Fe(III) with EDTA solution.

  15. Experimental Determination of the 24Mg I (3s3p)3P2 Lifetime

    Jensen, Brian Bak; He, Ming; Westergaard, Philip Grabow;

    2011-01-01

    We present the first experimental determination of the electric-dipole forbidden (3s3p)3P2¿(3s2)1S0 (M2) transition rate in 24Mg and compare to state-of-the-art theoretical predictions. Our measurement exploits a magnetic trap isolating the sample from perturbations and a magneto-optical trap as an...

  16. Stark broadening of 3s 3P0-3p 3D and 3p 3D-3d 3F0 transitions along carbon isoelectronic sequences of ions revisited

    The Stark widths of N II and O III spectral lines belonging to 3s 3P0-3p 3D and 3p 3D-3d 3F0 multiplets have been calculated and measured in a capillary discharge plasma. The calculations are extended to the same multiplets of F IV and Ne V ions. The plasma electron density in the capillary discharge is determined from the width of the He II Pβ line, while the electron temperature is measured from the relative intensities of N II lines. A comparison of the experimental and theoretical data shows good mutual agreement, which is well within the estimated experimental and theoretical uncertainties. The theory predicts the ratio of the corresponding N II to O III line widths to be larger than unity, in disagreement with our earlier experiment in a pulsed arc. In the new experiment, where all spectral lines were recorded under the same plasma conditions, the theoretical predictions and the results of the capillary experiment are in agreement. The possible sources of an error in the earlier experiment are indicated

  17. Cu6Te3S. A Cu-filled Cr3Si-structure variant

    A solid state melting and annealing route was used to prepare Cu6Te3S, a copper telluride sulfide representing a filled variant of the Cr3Si structure type. The title compound exhibits a reversible phase transition at 404 K which was confirmed by thermal analysis, temperature dependent X-ray single crystal and powder diffractometry. Both polymorphs crystallize cubic in space groups P anti 43n and P213, respectively. X-ray photoelectron spectroscopy (XPS) was performed to evaluate the electronic structure of Cu6Te3S and to determine the oxidation state of Cu in the title compound.

  18. Influence of Optical Properties on the Spin Polarization of Cu3P Photoelectrons

    Chassé, A.; Niebergall, L.

    We have investigated the influence of optical properties of Cu(001) on the spin polarization in Cu3p photoelectron diffraction patterns. The refraction and absorption of light have been taken into account in the calculation of the dipole transition matrix element. Therefore, a general polarization vector of light is defined within a macroscopic theory of electromagnetic fields. Results are shown and discussed for Cu3p photoelectrons excited by linearly or circularly polarized light, respectively. It is shown that the optical behavior of crystals may cause a symmetry breaking in the angular dependence of the photoelectron intensity. Besides, there are strong quantitative changes in the related spin polarization of Cu3p photoelectrons.

  19. 'Oxygen' effect in ionization loss spectrum of Cu3p in YBa2Cu3Ox ceramics

    YBaCu3Ox ceramic samples with different oxygen concentration (6.2; 6.5 and 6.9) in a volume are investigated. The process of degradation of samples with high X in the vacuum is analyzed. The surface purification is performed through scribing in argon atmosphere. A new effect is ascertained which is manifested in high sensitivity of Cu3p ionization loss spectrum to the density of the non-occupied electron states at the Fermi level. It is shown that Cu3p ionization spectrum can serve as a new criterion of superconductor surface quality from the viewpoint of its electronic structure

  20. Redox mechanism in the binary transition metal phosphide Cu3P

    Mauvernay, B.; Doublet, M.-L.; Monconduit, L.

    2006-05-01

    The electrochemical behaviour of the binary transition metal phosphide Cu3P towards lithium is investigated through galvano- and potentiostatic measurements. Obtained through high-temperature synthesis, this system shows a better volumetric capacity than graphite and a good capacity retention. In situ X-ray diffraction and first-principles electronic structure calculations are combined with the electrochemical results to show that the complete insertion of 3Li+ in the Cu3P electrode proceeds with the formation of three intermediate phases of lithium composition LixCu(3-x)P (x=1,2,3). The extra capacity previously observed in discharge is now clearly assigned to lithium insertion into the CuP2 impurity and to SEI reactions.

  1. Long-range interactions between a He($2 ^3S$) atom and a He($2 ^3P$) atom for like isotopes

    Zhang, J Y; Sadeghpour, H R; Vrinceanu, D; Yan, Z C; 10.1103/.73.022710

    2006-01-01

    For the interactions between a He($2 ^3S$) atom and a He($2 ^3P$) atom for like isotopes, we report calculations of the coefficients determining the potential energies at large internuclear separations. Using accurate variational wave functions in Hylleraas coordinates we evaluate the coefficient $C_{3}$ of the resonant dipole-dipole energy, and the van der Waals coefficients $C_{6}$, $C_{8}$, and $C_{10}$ of the energies arising from the mutual perturbations of instantaneous electric dipole, quadrupole, and octupole interactions. We establish definitive values including treatment of the finite nuclear mass for the ${}^3$He($2 ^3S$)--${}^3$He($2 ^3P$) and ${}^4$He($2 ^3S$)--${}^4$He($2 ^3P$) interactions.

  2. Theoretical study of Na(4p2P)+Na(3s2S) and Cd(5p3P0)+Na(3s2S) collisions and their role in the energy transfer between Cd* and Na

    We have computed the cross sections for the energy transfer process Cd(5p3P0) + Na(3s2S) →Cd(5s1S) + Na(4p2P) and for the state changing collision Na(4p2P) + Na(3s2S)→Na(3d2D) + Na(3s2S), based on theoretical interaction potentials for the NaCd and Na2 systems, respectively. Our calculations shed light on the interpretation of experiments with laser excited Na+Cd vapour mixtures. It turns out that Cd(5p3P0), in rapid equilibrium with the doorway state Cd(5p3P1), efficiently transfers energy to Na, populating the 4p2P state. The collisions with ground state Na cause a very fast conversion of the 4p2P to the 3d2D state, from which the strongest emission is observed. (orig.)

  3. Isotope shifts of the (3s3p) 3P0,1,2-(3s4s) 3S1 Mg I transitions

    He, Ming; Therkildsen, Kasper T.; Jensen, Brian B.;

    2009-01-01

    We report measurements of the isotope shifts of the (3s3p)P30,1,2-(3s4s)S31 Mg I transitions for the stable isotopes M24g (I=0) , M25g (I=5/2) , and M26g (I=0) . Furthermore, the M25g S31 hyperfine coefficient A(S31)=(-321.6±1.5)MHz is extracted and found to be in excellent agreement with state...

  4. Reverse energy-pooling collisions: K(5D)+Na(3S)→K(4P)+Na(3P)

    The observation of a heteronuclear reverse energy pooling process is reported. The cross section for the collision processes K(5D)+Na(3S)→K(4P)+Na(3P) has been measured and compared to calculations carried out using a multicrossing Landau-Zener model. copyright 1997 The American Physical Society

  5. Effects on intercombination transition rates and branching ratios-the UV0.01 (3s{sup 2}3p{sup 2} {sup 3}P{sub 1,2} - 3s3p{sup 3} {sup 5}S{sub 2}) multiplet in Si I-like ions revisited

    Andersson, Martin; Brage, Tomas [Department of Physics, Lund University, Box 118, SE-221 00 Lund (Sweden)

    2007-02-28

    We report on large-scale ab initio calculations for intercombination lines in Si I-like ions. Two measurable quantities, the lifetime of the 3s3p{sup 3} {sup 5}S{sub 2} level and the branching ratio of the two lines are discussed, to infer the importance of different features of our calculations. The effects of core polarization, two-body spin-dependent operators and Dirac contra Breit-Pauli approaches are discussed. Earlier calculations are reviewed and evaluated. The calculated lifetimes are in good agreement with experiments, while a discrepancy persists for branching ratios.

  6. Auger Spectra and Different Ionic Charges Following 3s, 3p and 3d Sub-Shells Photoionization of Kr Atoms

    Yehia A. Lotfy

    2006-01-01

    Full Text Available The decay of inner-shell vacancy in an atom through radiative and non-radiative transitions leads to final charged ions. The de-excitation decay of 3s, 3p and 3d vacancies in Kr atoms are calculated using Monte-Carlo simulation method. The vacancy cascade pathway resulted from the de-excitation decay of deep core hole in 3s subshell in Kr atoms is discussed. The generation of spectator vacancies during the vacancy cascade development gives rise to Auger satellite spectra. The last transitions of the de-excitation decay of 3s, 3p and 3d holes lead to specific charged ions. Dirac-Fock-Slater wave functions are adapted to calculate radiative and non-radiative transition probabilities. The intensity of Kr^{4+} ions are high for 3s hole state, whereas Kr^{3+} and Kr^{2+} ions have highest intensities for 3p and 3d hole states, respectively. The present results of ion charge state distributions agree well with the experimental data.

  7. Calculation of the photo-electrons angular distribution asymmetry parameter β2p near the (3s3p)Ip resonance of He

    Near the (3s3p)1p resonance of He, we have calculated the photo-electrons angular distribution asymmetry parameter β2p in the diagonalization approximation. Using the measured value of βn=2 near the (3s3p)1p level obtained by Lindle et al. in the resonance photo-ionization of He to He+(n=2), we have estimated the ratio R=σ2p/σ2s of the partial 2p photo-ionization cross section to the partial 2s photo-ionization cross section. Our calculation supports the result that in the resonance region, the formation of ions in the 2p level dominates over the 2s level. This is in good agreement with the experimental and most of the theoretical results reported to date. (author). 18 refs, 1 fig., 2 tabs

  8. High current Cu3P liquid metal ion source using a novel extractor configuration

    Higuchi-Rusli, R. H.; Corelli, J. C.

    1987-12-01

    It has been found that by utilizing a sharp needle for the extractor electrode in close proximity to the source tip wetted with Cu3P liquid alloy, a large increase (factor ˜300) in ion current is observed in comparison to standard liquid metal ion sources (LMIS's). In standard previously used LMIS's the extractor electrode was a flat plane with a circular hole centered on the source needle tip. This new high current source has important applications in focused and broad ion beam deposition systems.

  9. Colloidal CdSe/Cu3P/CdSe nanocrystal heterostructures and their evolution upon thermal annealing.

    De Trizio, Luca; De Donato, Francesco; Casu, Alberto; Genovese, Alessandro; Falqui, Andrea; Povia, Mauro; Manna, Liberato

    2013-05-28

    We report the synthesis of colloidal CdSe/Cu(3)P/CdSe nanocrystal heterostructures grown from hexagonal Cu(3)P platelets as templates. One type of heterostructure was a sort of "coral", formed by vertical pillars of CdSe grown preferentially on both basal facets of a Cu(3)P platelet and at its edges. Another type of heterostructure had a "sandwich" type of architecture, formed by two thick, epitaxial CdSe layers encasing the original Cu(3)P platelet. When the sandwiches were annealed under vacuum up to 450 °C, sublimation of P and Cd species with concomitant interdiffusion of Cu and Se species was observed by in situ HR- and EFTEM analyses. These processes transformed the starting sandwiches into Cu2Se nanoplatelets. Under the same conditions, both the pristine (uncoated) Cu(3)P platelets and a control sample made of isolated CdSe nanocrystals were stable. Therefore, the thermal instability of the sandwiches under vacuum might be explained by the diffusion of Cu species from Cu(3)P cores into CdSe domains, which triggered sublimation of Cd, as well as out-diffusion of P species and their partial sublimation, together with the overall transformation of the sandwiches into Cu(2)Se nanocrystals. A similar fate was followed by the coral-like structures. These CdSe/Cu(3)P/CdSe nanocrystals are therefore an example of a nanostructure that is thermally unstable, despite its separate components showing to be stable under the same conditions. PMID:23557168

  10. Cross sections for the excitation of 3s,3p,3d,4p, and 4s manifolds in e-Ne collisions

    Theoretical differential and integral cross sections are reported for inelastic scattering of electrons by neon atoms for incident electron energies in the range of 20-100 eV. Transitions from the ground state to forty states associated with the 3s, 3p, 3d, 4s, and 4p manifolds were considered. The methods employed were the distorted wave approximation and first-order many-body theory, where the distorting potential includes the static-exchange potential. A comparison of our results with experimental data and other theoretical results are shown and discussed. (author)

  11. Radiative lifetime of the 3s3p exp 3(exp 5 S sub 2 exp 0) metastable level of P(+)

    Calamai, Anthony G.; Han, Xiaofeng; Parkinson, William H.

    1992-01-01

    The present experimental and theoretical results for the radiative lifetime of the 3s3p exp 3(exp 5 S sub 2 exp 0) metastable level of P(+) encompass an experimental determination of the (exp 5 S sub 2 exp 0) lifetime which represents the first measured lifetime of a low charge-state ion in the Si I sequence. This constitutes a fundamental test of the theoretical methods used to determine transition possibilities for intercombination lines involving this level, and suggests that theoretical techniques used to determine such transition probabilities in low-Z species of the Si I isoelectronic sequence should be reevaluated.

  12. Effects on intercombination transition rates and branching ratios-the UV0.01 (3s23p23P1,2 - 3s3p35S2) multiplet in Si I-like ions revisited

    We report on large-scale ab initio calculations for intercombination lines in Si I-like ions. Two measurable quantities, the lifetime of the 3s3p35S2 level and the branching ratio of the two lines are discussed, to infer the importance of different features of our calculations. The effects of core polarization, two-body spin-dependent operators and Dirac contra Breit-Pauli approaches are discussed. Earlier calculations are reviewed and evaluated. The calculated lifetimes are in good agreement with experiments, while a discrepancy persists for branching ratios

  13. Characterization of Cu3P phase in Sn3.0Ag0.5Cu0.5P/Cu solder joints

    Jian-xun Chen; Xing-ke Zhao; Xu-chen Zou; Ji-hua Huang; Hai-chun Hu; Hai-lian Luo

    2014-01-01

    This article reports the effects of phosphorus addition on the melting behavior, microstructure, and mechanical properties of Sn3.0Ag0.5Cu solder. The melting behavior of the solder alloys was determined by differential scanning calorimetry. The interfacial micro-structure and phase composition of solder/Cu joints were studied by scanning electron microscopy and energy dispersive spectrometry. Thermodynamics of Cu-P phase formation at the interface between Sn3.0Ag0.5Cu0.5P solder and the Cu substrate was characterized. The results indicate that P addition into Sn3.0Ag0.5Cu solder can change the microstructure and cause the appearance of rod-like Cu3P phase which is distributed randomly in the solder bulk. The Sn3.0Ag0.5Cu0.5P joint shows a mixture of ductile and brittle fracture after shear test-ing. Meanwhile, the solidus temperature of Sn3.0Ag0.5Cu solder is slightly enhanced with P addition.

  14. Characterization of Cu3P phase in Sn3.0Ag0.5Cu0.5P/Cu solder joints

    Chen, Jian-xun; Zhao, Xing-ke; Zou, Xu-chen; Huang, Ji-hua; Hu, Hai-chun; Luo, Hai-lian

    2014-01-01

    This article reports the effects of phosphorus addition on the melting behavior, microstructure, and mechanical properties of Sn3.0Ag0.5Cu solder. The melting behavior of the solder alloys was determined by differential scanning calorimetry. The interfacial microstructure and phase composition of solder/Cu joints were studied by scanning electron microscopy and energy dispersive spectrometry. Thermodynamics of Cu-P phase formation at the interface between Sn3.0Ag0.5Cu0.5P solder and the Cu substrate was characterized. The results indicate that P addition into Sn3.0Ag0.5Cu solder can change the microstructure and cause the appearance of rod-like Cu3P phase which is distributed randomly in the solder bulk. The Sn3.0Ag0.5Cu0.5P joint shows a mixture of ductile and brittle fracture after shear testing. Meanwhile, the solidus temperature of Sn3.0Ag0.5Cu solder is slightly enhanced with P addition.

  15. Measurement of the spin-forbidden decay rate (3s3d)1D2¿(3s3p)3 P2,1 in 24Mg

    Therkildsen, K. T.; Jensen, Brian Bak; Ryder, C. P.; Malossi, N.; Thomsen, Jan Westenkær

    2009-01-01

    We have measured the spin-forbidden decay rate from (3s3d)D12¿(3s3p)P32,1 in M24g atoms trapped in a magneto-optical trap. The total decay rate, summing up both exit channels (3s3p)P31 and (3s3p)P32 , yields 196±10s-1 in excellent agreement with resent relativistic many-body calculations of Porsev...

  16. Laser-induced fluorescence and polarized light in the collision regime: the He(2s 3S → 4p 3P) case

    Laser-induced fluorescence experiments carried out using linearly polarized photons from a pulsed laser on a He(2s 3S → 4p 3P) excitation-detection scheme in electrical discharges at 0.04-0.6 Torr, show that light emitted during the interaction and in the subsequent decay manifests anisotropy in its angular distribution and polarization. A rate equation approach is used to discuss the general features of the interaction between polarized light and atoms observed experimentally. The incident electromagnetic field is decomposed into multipolar components that may interact with the atom through an appropriate coupling. Defining the Einstein coefficients for each coupling, it is possible to introduce the equations for the dynamics of the atomic populations. For each direction and polarization, the temporal profile of the intensity during the transition is calculated. The theoretical prediction explains the outcome of the He experiment satisfactorily. (author)

  17. Excitation of the OI (3s 5S0-3p 5P; lambda 7774 A) multiplet by electron impact on O2

    Erdman, P. W.; Zipf, E. C.

    1987-01-01

    Electron impact on O2 has been employed to ascertain the absolute cross-section value and emission linewidths of the OI (3s 5S0-3p 5P; 7774 A) multiplet. The emission linewidths are highly Doppler-broadened in dissociative excitation, and display two distinct kinetic energy distributions: which indicate that both purely repulsive and discrete, bound, excited molecular states, which then predissociate, are involved in the dissociation process that leads to the excitation of OI 7774 A. The magnitude of the measured cross-section and the fragment kinetic energy distribution both indicate that the previous time-of-flight studies of the metastable OI (5S0) state require reinterpretation.

  18. Photovoltaic effect of n-In_2O_3/p-Cu_2O heterojunction thin film cells

    NAKAZAWA, Tatsuo; KURANOUCHI, Shin'ichi

    1992-01-01

    Electrical and photovoltaic characteristics of n-In_2O_3/p-Cu_2O heterojunction thin film cells were investigated. Cu_2O semiconducting films were prepared by simple method of thermal oxidation of copper foil in air. Conversion efficiency of 0.57% was obtained under illumination of the sunlight. It is thought that a high series resistance of the diode, which originated from a interface between Cu_2O film and copper foil, causes the poor characteristics. Photovoltaic characteristics of the cel...

  19. Effects of non-adiabatic and Coriolis couplings on the bound states of He(2 ^3S)+He(2 ^3P)

    Cocks, Daniel G; Peach, Gillian

    2009-01-01

    The effects of non-adiabatic and Coriolis couplings on the bound states of the He(2 ^3S_1)+He(2 ^3P_j) system, where j=0,1,2, are investigated using the recently available ab initio short-range $^{1,3,5}\\Sigma^{+}_{g,u}$ and $^{1,3,5}\\Pi_{g,u}$ potentials computed by Deguilhem et al. (J. Phys. B: At. Mol. Opt. Phys. 42 (2009) 015102). Three sets of calculations have been undertaken: single-channel, multichannel without Coriolis couplings and full multichannel with Coriolis couplings. We find that non-adiabatic effects are negligible for 0^-_u,0^\\pm_g,1_u,2_g,3_g Hund case (c) sets of levels in the j=2 asymptote but can be up to 6% for some of the 0^+_u and 1_g sets of levels where near degeneracies are present in the single-channel diagonalized potentials. Coriolis couplings are most significant for weakly bound levels, ranging from 1-5% for total angular momenta J=1,2 and up to 10% for J=3. Levels near the j=1 and j=0 asymptotes agree closely with previous multichannel calculations based upon long-range pote...

  20. Two-step laser excitation of 4snd 3D1,2,3 and 4sns 3S1 states from the 4s4p 3P levels in zinc

    We present new experimental data on the term energies and quantum defects of the even-parity triplet states of zinc using a two-step laser excitation scheme in conjunction with a thermionic diode ion detector. The first laser was fixed at 32 501.399 cm-1 to populate the 4s4p 3P1 intermediate level. The 4s4p 3P0,2 fine structure components get populated through collisional energy transfer. The second laser was scanned covering the energy region 43 200 to 42 000 cm-1 revealing the highly excited states up to the first ionization limit. Our observations include 4snd 3D2 (14 ≤ n ≤ 55) and 4sns 3S1 (15 ≤ n ≤ 35) Rydberg series excited from the 4s4p 3P1 level. In addition, 4snd 3D3 (13 ≤ n ≤ 49) and 4snd 3D1 (10 ≤ n ≤ 20) series including few members of the 4sns 3S1 series have also been observed from the 4s4p 3P2 and 4s4p 3P0 levels, respectively. The binding energy of 4s4p 3P1 has been determined as 43 267.93 ± 0.02 cm-1, which consequently yields the first ionization potential of zinc as 75 769.35 ± 0.05 cm-1, which is in good agreement with that reported previously

  1. Influence of relaxation effects on probabilities of the 2s2p3 S2—2s2 2p2 3p1,2intercombination

    袁萍; 刘欣生; 等

    2003-01-01

    Transition probabilities of the 2s2p3 5S2-2s2 2P2 3P1,2 intercombination transitions in NII have been calculated by using a large-scale multiconfiguration Dirac-Fock method.In the calculation themost important effects of relativity,correlation,and relaxation are considered.From the calculated transition probabilities,the lifetime of the s22p3 5S2 metastable state is derived.The result is in excellent agreement agreement with the latest experimental result.In the meantime the influence of anomalously strong relaxation effects on probabilities of the 2s2p3 5S2-2s2 2p2 3P1,2 lines in NII have been found.

  2. Self-supported Cu3P nanowire arrays as an integrated high-performance three-dimensional cathode for generating hydrogen from water.

    Tian, Jingqi; Liu, Qian; Cheng, Ningyan; Asiri, Abdullah M; Sun, Xuping

    2014-09-01

    Searching for inexpensive hydrogen evolution reaction (HER) electrocatalysts with high activity has attracted considerable research interest in the past years. Reported herein is the topotactic fabrication of self-supported Cu3 P nanowire arrays on commercial porous copper foam (Cu3 P NW/CF) from its Cu(OH)2 NW/CF precursor by a low-temperature phosphidation reaction. Remarkably, as an integrated three-dimensional hydrogen-evolving cathode operating in acidic electrolytes, Cu3 P NW/CF maintains its activity for at least 25 hours and exhibits an onset overpotential of 62 mV, a Tafel slope of 67 mV dec(-1) , and a Faradaic efficiency close to 100 %. Catalytic current density can approach 10 mA cm(-2) at an overpotential of 143 mV. PMID:25044801

  3. 弛豫与关联效应对NII离子2s22p3s3P1-2s22p2 1D2与2s22p3s 1P1-2s22p2 3P0,1,2自旋禁戒跃迁概率的影响%Influence of relaxation and correlation effects on probabilities of the 2s22p3s 3P1-2s22p2 1D2 and 2s22p3s 1P1-2s22p2 3P0,1,2 intercombination transitions in NII

    袁萍; 刘欣生; 张义军; 颉录有; 董晨钟

    2003-01-01

    用多组态Dirac-Fock方法,并系统考虑相对论效应、电子关联、弛豫效应等重要贡献,计算了NII离子2s22p3s 3P1-2s22p2 1D2和2s22p3s 1P1-2s22p2 3P0,1,2自旋禁戒跃迁概率和振子强度.通过比较计算证实:弛豫和关联效应对禁戒跃迁概率的影响非常大,考虑了这些效应后,计算结果有显著的改善.由跃迁概率和振子强度的计算值推断,2s22p3s 3P1-2s22p2 1D2的谱线强度应该比原有的理论预言值小.

  4. Cu3P

    Villars, P.; Cenzual, K.; Daams, J.; Gladyshevskii, R.; Shcherban, O.; Dubenskyy, V.; Melnichenko-Koblyuk, N.; Pavlyuk, O.; Savysyuk, I.; Stoyko, S.; Sysa, L.

    This document is part of Subvolume A6 `Structure Types. Part 6: Space Groups (166) R-3m - (160) R3m' of Volume 43 `Crystal Structures of Inorganic Compounds' of Landolt-Börnstein - Group III `Condensed Matter'.

  5. Effects of non-adiabatic and Coriolis couplings on the bound states of He(2 3S)+He(2 3P)

    The effects of non-adiabatic and Coriolis couplings on the bound states of the He(2 3S1) + He(2 3Pj) system, where j = 0, 1, 2, are investigated using the recently available ab initio short-range 1,3,5Σ+g,u and 1,3,5Πg,u potentials computed by Deguilhem et al (2009 J. Phys. B: At. Mol. Opt. Phys. 42 015102). Three sets of calculations have been undertaken: single-channel, multichannel without Coriolis couplings and full multichannel with Coriolis couplings. We find that non-adiabatic effects are negligible for 0-u, 0±g, 1u, 2g, 2u, 3g Hund case (c) sets of levels in the j = 2 asymptote but can be up to 15% for some of the 0+u and 1g sets of levels where near degeneracies are present in the single-channel diagonalized potentials. Coriolis couplings are most significant for weakly bound levels, ranging from 1% to 5% for total angular momenta J = 1, 2 and up to 10% for J = 3. Levels near the j = 1 and j = 0 asymptotes agree closely with previous multichannel calculations based upon long-range potentials constructed from retarded resonance dipole and dispersion interactions. Assignment of theoretical levels to experimental observations using criteria based upon the short-range character of each level and their coupling to metastable ground states produces well-matched assignments for the majority of observations. After a 1% increase in the slope of the 5Σ+g,u and 5Πg,u input potentials near the classical turning point is applied, improved matching of previous assignments is obtained and further assignments can be made, reproducing very closely the number of experimental observations.

  6. Comparative study of structural and morphological properties of CuIn{sub 3}S{sub 5} and CuIn{sub 7}S{sub 11} materials

    Khemiri, N., E-mail: naoufel_khemiri@yahoo.f [Laboratoire de Photovoltaique et Materiaux Semi-conducteurs, ENIT BP 37, Le belvedere 1002-Tunis (Tunisia); Kanzari, M. [Laboratoire de Photovoltaique et Materiaux Semi-conducteurs, ENIT BP 37, Le belvedere 1002-Tunis (Tunisia)

    2010-02-15

    CuIn{sub 3}S{sub 5} and CuIn{sub 7}S{sub 11} powders were prepared by solid-state reaction method using high-purity elemental copper, indium and sulphur. The films prepared from CuIn{sub 3}S{sub 5} and CuIn{sub 7}S{sub 11} powders were grown by thermal evaporation under vacuum (10{sup -6} Torr) on glass substrates at different substrate temperature Ts varying from room temperature to 200 deg. C. The powders and thin films were characterized for their structural properties by using X-ray diffraction (XRD) and energy dispersive X-ray (EDX). Both powders were polycrystalline with chalcopyrite and spinel structure, respectively. From the XRD data, we calculated the lattice parameters of the structure for the compounds. For CuIn{sub 3}S{sub 5} powder, we also calculated the cation-anion bond lengths. The effect of substrate temperature Ts on the structural properties of the films, such as crystal phase, preferred orientation and crystallinity was investigated. Indeed, X-ray diffraction analysis revealed that the films deposited at a room temperature (30 deg. C) are amorphous in nature while those deposited on heated were polycrystalline with a preferred orientation along (1 1 2) of the chalcopyrite phase and (3 1 1) of the spinel phase for CuIn{sub 3}S{sub 5} and CuIn{sub 7}S{sub 11} films prepared from powders, respectively. The morphology of the films was determined by atomic force microscopy AFM. The surface roughness and the grain size of the films increase on increasing the substrate temperature.

  7. Cu{sub 6}Te{sub 3}S. A Cu-filled Cr{sub 3}Si-structure variant

    Giller, Malte; Grotz, Carolin; Nilges, Tom [Technische Universitaet Muenchen, Garching (Germany). Dept. of Chemistry; Rudyk, Brent W.; Mar, Arthur [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemistry

    2014-07-01

    A solid state melting and annealing route was used to prepare Cu{sub 6}Te{sub 3}S, a copper telluride sulfide representing a filled variant of the Cr{sub 3}Si structure type. The title compound exhibits a reversible phase transition at 404 K which was confirmed by thermal analysis, temperature dependent X-ray single crystal and powder diffractometry. Both polymorphs crystallize cubic in space groups P anti 43n and P2{sub 1}3, respectively. X-ray photoelectron spectroscopy (XPS) was performed to evaluate the electronic structure of Cu{sub 6}Te{sub 3}S and to determine the oxidation state of Cu in the title compound.

  8. Nano-sized quaternary CuGa2In3S8 as an efficient photocatalyst for solar hydrogen production

    Kandiel, Tarek

    2014-09-03

    The synthesis of quaternary metal sulfide (QMS) nanocrystals is challenging because of the difficulty to control their stoichiometry and phase structure. Herein, quaternary CuGa2In3S8 photocatalysts with a primary particle size of ≈4nm are synthesized using a facile hot-injection method by fine-tuning the sulfur source injection temperature and aging time. Characterization of the samples reveals that quaternary CuGa2In3S8 nanocrystals exhibit n-type semiconductor characteristics with a transition band gap of ≈1.8eV. Their flatband potential is located at -0.56V versus the standard hydrogen electrode at pH6.0 and is shifted cathodically by 0.75V in solutions with pH values greater than 12.0. Under optimized conditions, the 1.0wt% Ru-loaded CuGa2In3S8 photocatalyst exhibits a photocatalytic H2 evolution response up to 700nm and an apparent quantum efficiency of (6.9±0.5)% at 560nm. These results indicate clearly that QMS nanocrystals have great potential as nano-photocatalysts for solar H2 production. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Study of χ{sub b} meson production in pp collisions at √(s) = 7 and 8 TeV and observation of the decay χ{sub b} (3P) → Υ (3S

    Aaij, R. [Nikhef National Institute for Subatomic Physics, Amsterdam (Netherlands); Adeva, B. [Universidad de Santiago de Compostela (Spain); Adinolfi, M. [Bristol Univ. (United Kingdom). H.H. Wills Physics Lab.; and others

    2014-10-15

    A study of χ{sub b} meson production at LHCb is performed on proton-proton collision data, corresponding to 3.0 fb{sup -1} of integrated luminosity collected at centre-of-mass energies √(s) = 7 and 8 TeV. The fraction of Υ(nS) mesons originating from χ{sub b} decays is measured as a function of the Υ transverse momentum in the rapidity range 2.0 < y{sup Υ} < 4.5. The radiative transition of the χ{sub b} (3P) meson to Υ(3S) is observed for the first time. The χ{sub b1} (3P) mass is determined to be m{sub χ{sub b{sub 1{sub ({sub 3{sub P{sub )}}}}}}} = 10 511.3 ± 1.7 ± 2.5MeV/c{sup 2}, where the first uncertainty is statistical and the second is systematic. (orig.)

  10. Determination and analysis of dispersive optical constants of CuIn{sub 3}S{sub 5} thin films

    Khemiri, N., E-mail: naoufel_khemiri@yahoo.f [Laboratoire de Photovoltaique et Materiaux Semiconducteurs-ENIT, Universite Tunis, ElManar BP 37, Le belvedere, 1002 Tunis (Tunisia); Sinaoui, A.; Kanzari, M. [Laboratoire de Photovoltaique et Materiaux Semiconducteurs-ENIT, Universite Tunis, ElManar BP 37, Le belvedere, 1002 Tunis (Tunisia)

    2011-04-15

    CuIn{sub 3}S{sub 5} thin films were prepared from powder by thermal evaporation under vacuum (10{sup -6} mbar) onto glass substrates. The glass substrates were heated from 30 to 200 {sup o}C. The films were characterized for their optical properties using optical measurement techniques (transmittance and reflectance). We have determined the energy and nature of the optical transitions of films. The optical constants of the deposited films were determined in the spectral range 300-1800 nm from the analysis of transmission and reflection data. The Swanepoel envelope method was employed on the interference fringes of transmittance patterns for the determination of variation of refractive index with wavelength. Wemple-Di Domenico single oscillator model was applied to determine the optical constants such as oscillator energy E{sub 0} and dispersion energy E{sub d} of the films deposited at different substrate temperatures. The electric free carrier susceptibility and the ratio of the carrier concentration to the effective mass were estimated according to the model of Spitzer and Fan.

  11. A Novel Sr2CuInO3S p-type semiconductor photocatalyst for hydrogen production under visible light irradiation

    Yushuai Jia; Jingxiu Yang; Dan Zhao; Hongxian Han; Can Li

    2014-01-01

    A novel Sr2CuInO3S oxysulfide p-type semiconductor photocatalyst has been prepared by solid state reaction method and it exhibits intriguing visible light absorption properties with a bandgap of 2.3 eV. The p-type semiconductor character of the synthesized Sr2CuInO3S was confirmed by Hall efficient measurement and Mott-Schottky plot analysis. First-principles density functional theory calculations (DFT) and electrochem-ical measurements were performed to elucidate the electronic structure and the energy band locations. It was found that the as-synthesized Sr2CuInO3S photocatalyst has appreciate conduction and valence band positions for hydrogen and oxygen evolution, respectively. Photocat-alytic hydrogen production experiments under a visible light irradiation (λ>420 nm) were carried out by loading different metal and metal-like cocatalysts on Sr2CuInO3S and Rh was found to be the best one among the tested ones.

  12. Preparation of Cu2Sn3S7 Thin-Film Using a Three-Step Bake-Sulfurization-Sintering Process and Film Characterization

    Tai-Hsiang Lui

    2015-01-01

    Full Text Available Cu2Sn3S7 (CTS can be used as the light absorbing layer for thin-film solar cells due to its good optical properties. In this research, the powder, baking, sulfur, and sintering (PBSS process was used instead of vacuum sputtering or electrochemical preparation to form CTS. During sintering, Cu and Sn powders mixed in stoichiometric ratio were coated to form the thin-film precursor. It was sulfurized in a sulfur atmosphere to form CTS. The CTS film metallurgy mechanism was investigated. After sintering at 500°C, the thin film formed the Cu2Sn3S7 phase and no impurity phase, improving its energy band gap. The interface of CTS film is continuous and the formation of intermetallic compound layer can increase the carrier concentration and mobility. Therefore, PBSS process prepared CTS can potentially be used as a solar cell absorption layer.

  13. Bonding Quandary in the [Cu3S2](3+) Core: Insights from the Analysis of Domain Averaged Fermi Holes and the Local Spin

    Ponec, Robert; Ramos-Córdoba, E.; Salvador, P.

    2013-01-01

    Roč. 117, č. 9 (2013), s. 1975-1982. ISSN 1089-5639 R&D Projects: GA ČR GA203/09/0118 Grant ostatní: SMCT(ES) MAT2008-04834; SMCT(ES) CTQ2011-23441/BQU; SFPU(ES) AP2008-01231 Institutional support: RVO:67985858 Keywords : Cu3S2 core * dafh analysis * bonding quandary Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.775, year: 2013

  14. Development of a tunable Fabry-Perot etalon-based near-infrared interference spectrometer for measurement of the HeI 2{sup 3}S-2{sup 3}P spectral line shape in magnetically confined torus plasmas

    Ogane, S.; Shikama, T., E-mail: shikama@me.kyoto-u.ac.jp; Hasuo, M. [Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto 615-8540 (Japan); Zushi, H. [Research Institute for Applied Mechanics, Kyushu University, Fukuoka 816-8580 (Japan)

    2015-10-15

    In magnetically confined torus plasmas, the local emission intensity, temperature, and flow velocity of atoms in the inboard and outboard scrape-off layers can be separately measured by a passive emission spectroscopy assisted by observation of the Zeeman splitting in their spectral line shape. To utilize this technique, a near-infrared interference spectrometer optimized for the observation of the helium 2{sup 3}S–2{sup 3}P transition spectral line (wavelength 1083 nm) has been developed. The applicability of the technique to actual torus devices is elucidated by calculating the spectral line shapes expected to be observed in LHD and QUEST (Q-shu University Experiment with Steady State Spherical Tokamak). In addition, the Zeeman effect on the spectral line shape is measured using a glow-discharge tube installed in a superconducting magnet.

  15. A facile synthesis of MInSe2 (M = Cu, Ag) via low temperature pyrolysis of single source molecular precursors, [(R3P)2MIn(SeCOAr)4

    Shamik Ghoshal; Liladhar B Kumbhare; Vimal K Jain; Gautam K Dey

    2007-04-01

    The reaction of KSeCOAr with InCl3 and [MCl(PR3)2] in benzene afforded bimetallic complexes, [(R3P)2MIn(SeCOAr)4] (PR3 = PEt3 or PPh3; M = Cu or Ag; Ar = –C6H5 (phenyl) or 4-MeC6H4 (tolyl)). The triethylphosphine complexes decomposed rapidly when M = Ag while slowly when M = Cu. All these complexes were characterized by elemental analysis, IR, UV-VIS, NMR (1H, 31P) spectral data. Pyrolysis in a furnace at 300°C gave tetragonal MInSe2 (M = Cu, Ag) structure. Solvothermal decomposition of [(PPh3)2CuIn(SeCOAr)4] in boiling ethylene glycol gave nanorods of CuInSe2 which were characterized by XRD, EDAX, SEM and TEM.

  16. 高剥离类镁等电子序列的磁偶极MI和电四极E2光谱跃迁理论研究%HIGHLY STRIPPED MAGNETIC DIPOLE M1 AND ELECTRIC QUADRUPOLE E2 TRANSITIONS IN THE 3s3p CONFIGURATION OF THE Mg-LIKE IONS

    易有根; 郑志坚; 唐永建; 朱正和

    2003-01-01

    利用全相对论性多组态Dirac-Fock广义平均能级方法,系统地计算了类镁离子3s3p 磁偶极M1 3 P2-3P1 和电四极E2 3 P2-3P0(Z=20~103)光谱跃迁的能级间隔、跃迁几率和振子强度.计算中考虑了原子核的有限体积效应,进行了高阶Breit修正和QED修正,所得到的能级间隔和最近的实验数据及理论计算值进行了比较.计算结果表明:高原子序数的高荷电离子的磁偶极矩M1和电四极矩E2跃迁几率和中性原子的电偶极E1的相当,在ICF和MCF高温激光等离子体中,磁偶极矩M1和电四极矩E2跃迁过程不容被忽视.

  17. Crystal momentum dependence of the correlation satellite intensity in the 3p → 3d resonant photoemission spectra of Bi2Sr2CaCu2O8 + δ

    Goldoni, A.; Corradini, V.; del Pennino, U.; Sangalli, P.; Parmigiani, F.; Avila, J.; Teodorescu, C.

    2000-05-01

    Angle-resolved resonant photoemission measurements at the Cu3pCu3d threshold have been performed on the superconducting cuprate Bi2Sr2CaCu2O8 + δ. We have investigated in particular the correlation satellite appearing in the valence band photoemission spectrum to investigate the effect of solid state on the interference effect occurring at resonance. We found that the intensity of the correlation satellite changes with the electron take-off angle in a way that depends on the particular crystallographic direction and on the sample hole doping. These results indicate that the intensity enhancement at the absorption edge is a real resonance albeit the intermediate state in the autoionization process is partly delocalised. This fact does not prevent the occurrence of interference between indirect and direct photoemission.

  18. Crystal momentum dependence of the correlation satellite intensity in the 3p {yields} 3d resonant photoemission spectra of Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}}

    Goldoni, A. [INFM, Trieste (Italy); Corradini, V.; Del Pennino, U. [INFM, Modena (Italy); Sangalli, P. [INFM, Pavia (Italy); Parmigiani, F. [INFM, Brescia (Italy); Avila, J. [CSIC, Madrid (Spain). Inst. de Ciencia de Materiales; Laboratoire pour l' Utilisation du Rayonnement Electromagnetique (LURE), Paris-11 Univ., 91 - Orsay (France); Teodorescu, C. [Laboratoire pour l' Utilisation du Rayonnement Electromagnetique (LURE), Paris-11 Univ., 91 - Orsay (France)

    2000-05-01

    Angle-resolved resonant photoemission measurements at the Cu3p {yields} Cu3d threshold have been performed on the superconducting cuprate Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}}. We have investigated in particular the correlation satellite appearing in the valence band photoemission spectrum to investigate the effect of solid state on the interference effect occurring at resonance. We found that the intensity of the correlation satellite changes with the electron take-off angle in a way that depends on the particular crystallographic direction and on the sample hole doping. These results indicate that the intensity enhancement at the absorption edge is a real resonance albeit the intermediate state in the autoionization process is partly delocalised. This fact does not prevent the occurrence of interference between indirect and direct photoemission. (orig.)

  19. Crystal momentum dependence of the correlation satellite intensity in the 3p → 3d resonant photoemission spectra of Bi2Sr2CaCu2O8+δ

    Angle-resolved resonant photoemission measurements at the Cu3pCu3d threshold have been performed on the superconducting cuprate Bi2Sr2CaCu2O8+δ. We have investigated in particular the correlation satellite appearing in the valence band photoemission spectrum to investigate the effect of solid state on the interference effect occurring at resonance. We found that the intensity of the correlation satellite changes with the electron take-off angle in a way that depends on the particular crystallographic direction and on the sample hole doping. These results indicate that the intensity enhancement at the absorption edge is a real resonance albeit the intermediate state in the autoionization process is partly delocalised. This fact does not prevent the occurrence of interference between indirect and direct photoemission. (orig.)

  20. A structural comparison of two thallium copper erbium sulfides. TlCu{sub 3}Er{sub 2}S{sub 5} and Tl{sub 2}Cu{sub 5}Er{sub 3}S{sub 8}

    Eberle, Marcel A.; Schleid, Thomas [Univ. of Stuttgart (Germany). Inst. of Inorganic Chemistry; Babo, Jean-Marie [Univ. of Notre Dame, IN (United States). Dept. of Civil Engineering and Geological Sciences and Dept. of Chemistry and Biochemistry

    2014-08-15

    Orange TlCu{sub 3}Er{sub 2}S{sub 5} crystallizes in the orthorhombic space group Cmcm (a = 391.27(2), b = 1382.91(7), c = 1630.54(8) pm, Z = 4). Its crystal structure contains one Tl{sup +}, one Er{sup 3+}, two Cu{sup +}, and three S{sup 2-} ions as crystallographically unique components. All Cu{sup +} cations are coordinated by four S{sup 2-} anions to form [CuS{sub 4}]{sup 7-} tetrahedra, which have vertex- and edge-connectivity to build up {sub ∞}{sup 2}{[Cu_3S_5]"7"-} layers parallel to the (010) plane. The Er{sup 3+} cations are octahedrally surrounded by six S{sup 2-} anions. These [ErS{sub 6}]{sup 9-} units share trans-oriented edges forming linear chains, which are further linked by common vertices yielding {sub ∞}{sup 1}{[Er_2S_1_0]"1"4"-} double strands. Further fusion via common vertices results in {sub ∞}{sup 2}{[Er_2S_5]"4"-} layers parallel to the (010) plane. Alternatingly stacked along [010] and condensed via S{sup 2-} anions, these two types of layers form a three-dimensional framework, leaving tunnels along [100], where the Tl{sup +} cations fit in. These are each coordinated by eight S{sup 2-} anions in the shape of bicapped trigonal prisms. Tl{sub 2}Cu{sub 5}Er{sub 3}S{sub 8} was obtained as black single crystals with metallic luster (monoclinic, Cm, a = 1381.69(7), b = 390.73(2), c = 1435.98(7) pm, β =111.132(3) {sup circle}, Z = 2). Four of the five crystallographically different Cu{sup +} cations are tetrahedrally surrounded by S{sup 2-} anions, whereas (Cu3){sup +} is situated in sulfur triangles. Connected via common vertices and edges, the copper-sulfur polyhedra form strongly corrugated {sub ∞}{sup 2}{[Cu_5S_8]"1"1"-} layers parallel to the (20 anti 1) plane. All Er{sup 3+} cations are again coordinated by six S{sup 2-} anions in the shape of [ErS{sub 6}]{sup 9-} octahedra. Their condensation via edges and vertices leads to {sub ∞}{sup 2}{[Er_3S_8]"7"-} layers spreading out parallel to the (010) plane. Both types of anionic

  1. 3p deletion syndrome.

    Kaur, Anupam; Khetarpal, S

    2013-08-01

    3p deletion is a rare cytogenetic finding. Here we describe a 3 months old male with congenital malformations. His karyotype revealed 3p deletion 46,XY,del(3)(p25-pter). The child had flexion deformity of wrist and elbow which has never been reported before. PMID:24036645

  2. On the kinetic and thermodynamic fragility of the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} bulk metallic glasses

    Gallino, Isabella, E-mail: i.gallino@mx.uni-saarland.de [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Gross, Oliver [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Dalla Fontana, Giulia [Department of Chemistry IFM and NIS, University of Torino, V. Giuria 7, 10125 Torino (Italy); Evenson, Zach; Busch, Ralf [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany)

    2014-12-05

    Highlights: • The studied Pt–Cu–(Ni,Co)–P glasses are more fragile than Zr-based alloys. • They show large increases in the C{sub p} at T{sub g} and small barriers for cooperative rearrangements of atoms. • They have fragility parameters among the lowest reported for BMG systems (D{sup *} = 10–12). • They crystallize into a state that melts with distinctly high entropy of fusion. • The microscopic origin of their fragility seems different than that for Zr- and Pd-based BMGs. - Abstract: The investigations in this study focus on bulk metallic glass (BMG) alloy families based on noble metals like Pt, which are more kinetically fragile than Zr-based BMG systems. Thermophysical properties have been investigated by calorimetry and thermal mechanical analyses for the determination of the specific heat capacity and viscosity, respectively. For the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} BMG compositions consistent Vogel–Fulcher–Tammann (VFT) fits of the viscosity measurements are established, and the temperature dependence of the configurational entropy is calculated from thermodynamic data. Fits to the Adam–Gibbs equation are performed using this configurational entropy change. Their fragile nature is compared to that of Zr-based alloys in terms of structural considerations.

  3. Transition probability values of the 1s22s3p 3P0 level in Be-like ions

    Transition probability values from the 1s22s3p 3P0 level for selected beryllium-like ions, from Z = 5 to 92, are calculated using the multi-configuration Dirac–Fock method including QED corrections, and full correlation up to the 4f subshell in both initial and final levels, for 1s22s3s 3S1, 1s22s2p 3P2 level and 1s22p23P1 decay modes of this level. (paper)

  4. Fine-structure energy levels, oscillator strengths and lifetimes in Cu XVI

    Gupta, G P [Department of Physics, S D (Postgraduate) College, Muzaffarnagar-251 001 (Affiliated to Chowdhary Charan Singh University, Meerut-250 004) (India); Msezane, A Z, E-mail: g_p_gupta1@yahoo.co.in [Department of Physics and Center for Theoretical Studies of Physical Systems, Clark Atlanta University, Atlanta, GA 30314 (United States)

    2011-05-01

    We have performed large-scale CIV3 calculations of excitation energies from ground state for 69 fine-structure levels as well as of oscillator strengths and radiative decay rates for all electric-dipole-allowed and intercombination transitions among the fine-structure levels of the terms belonging to the (1s{sup 2}2s{sup 2}2p{sup 6})3s{sup 2}3p{sup 2}, 3s3p{sup 3}, 3p{sup 4}, 3s{sup 2}3p3d, 3s{sup 2}3p4s, 3s{sup 2}3p4p, 3s{sup 2}3p4d, and 3s{sup 2}3p4f configurations of Cu XVI. These states are represented by very extensive configuration-interaction (CI) wave functions obtained with the computer code CIV3 of Hibbert. The important relativistic effects in intermediate coupling are incorporated by means of the Breit-Pauli Hamiltonian. Small adjustments to the diagonal elements of the Hamiltonian matrices have been made so that the energy splittings are as close as possible to the energy values of those from the National Institute for Standards and Technology. The mixing among several fine-structure levels is found to be very strong. From our radiative decay rates we have also calculated radiative lifetimes of the fine-structure levels. Our calculated lifetime for the high spin level 3s3p{sup 3}({sup 5}S{sub 2}) is found to be in excellent agreement with the experimental value of Trabert et al (1988 J. Opt. Soc. Am. B 5 2173). In this calculation, we also predict new data for several fine-structure levels where no other theoretical and/or experimental results are available.

  5. Relativistic atomic data for Cu-like tungsten

    Safronova, U. I.; Safronova, A. S.; Beiersdorfer, P.

    2013-05-01

    Energy levels, radiative transition probabilities, and autoionization rates for [Ne] 3s2 3p6 3d9 4l' nl , [Ne] 3s2 3p5 3d10 4l' nl (n=4-6), and [Ne] 3s2 3p6 3d9 5l' nl ,(n=5-7) states in Cu-like tungsten (W45+) are calculated using the relativistic many-body perturbation theory method (RMBPT code), the multiconfiguration relativistic Hebrew University Lawrence Livermore Atomic Code (HULLAC code), and the Hartree-Fock-relativistic method (COWAN code). Branching ratios relative to the first threshold and intensity factors are calculated for satellite lines, and dielectronic recombination (DR) rate coefficients are determined for the singly excited, as well as doubly excited non-autoionizing states in Cu-like W45+ ion. Contributions from the autoionizing doubly excited states (with n up to 500), which are particulary important for calculating total DR rates, are estimated. Synthetic dielectronic satellite spectra from Cu-like W are simulated in a broad spectral range from 3 to 70 Å. These calculations provide highly accurate values for a number of W45+ properties useful for a variety of applications including for fusion applications. This research was sponsored by the grant DE-FG02-08ER54951.

  6. Energy and Auger Widths of Triply Excited 3p3p3p 2po State of Lithium

    苟秉聪; 俞开智

    2003-01-01

    The high-lying triply excited 3p3p3p 2po state of the double hollow lithium atom is studied by using the saddlepoint complex-rotation method. The energy and Auger widths of this resonance are calculated. The relativistic corrections and mass polarization are included. The total Auger width is obtained by coupling the important open channels and summing over the other channels. The oscillator strength is also calculated. The results are compared with other theoretical and experimental data in the literature.

  7. Investigation of the ({radical}3 x {radical}3)R30{sup o}-Cu{sub 2}Si/Cu(1 1 1) surface alloy using DFT

    Shuttleworth, I.G., E-mail: shuttleworth.ian@gmail.com [Jubail University College, Jubail Industrial City, 31961 (Saudi Arabia)

    2011-05-15

    The electronic structure of the FCC, HCP and 2-fold bridge phases of the ({radical}3 x {radical}3)R30{sup o}-Cu{sub 2}Si/Cu(1 1 1) surface alloy have been investigated using LCAO-DFT. Analysis of the total electron density, partial density-of-states (PDOS) and crystal orbital overlap population (COOP) curves for the system have shown a surprising similarity between the intra- and inter-layer Si-Cu bond for each phase. Low hybridization between the Si 3s and 3p orbitals results in a low directionality of the Si-Cu bond within each of phase. The Si 3s orbitals are shown to form covalent bonds with their surrounding Cu atoms whereas the Si 3p and 3d orbitals are shown to form combinations of covalent and metallic bonds. The Si-Cu interaction is shown clearly to extend to the second layer of the alloy in deference to previous studies of Si/Cu alloys.

  8. Thermoelastic properties of Zn3P2

    Gerward, Leif; Olsen, J. Staun; Waśkowska, A.

    2011-01-01

    The bulk modulus and thermal expansion of Zn3P2 has been investigated at pressures up to 21GPa and temperatures down to 100K. The experimental zero-pressure bulk modulus is 80.7 ± 1.8GPa, in accordance with the bulk modulus scaling and lattice properties of the related compound Cd3P2. A tetragonal...... to orthorhombic phase transformation occurs above 11GPa with a relative volume change of-7.1%. Values for the thermal expansion coefficient are reported at 293, 200 and 100K....

  9. Photoelectron diffraction of magnetic ultrathin films: Fe/Cu(001)

    Tobin, J.G. (Lawrence Livermore National Lab., CA (USA)); Wagner, M.K. (Wisconsin Univ., Madison, WI (USA). Dept. of Chemistry); Guo, X.Q.; Tong, S.Y. (Wisconsin Univ., Milwaukee, WI (USA). Dept. of Physics)

    1991-01-03

    The preliminary results of an ongoing investigation of Fe/Cu(001) are presented here. Energy dependent photoelectron diffraction, including the spin-dependent variant using the multiplet split Fe3s state, is being used to investigate the nanoscale structures formed by near-monolayer deposits of Fe onto Cu(001). Core-level photoemission from the Fe3p and Fe3s states has been generated using synchrotron radiation as the tunable excitation source. Tentatively, a comparison of the experimental Fe3p cross section measurements with multiple scattering calculations indicates that the Fe is in a fourfold hollow site with a spacing of 3.6{Angstrom} between it and the atom directly beneath it, in the third layer. This is consistent with an FCC structure. The possibility of utilizing spin-dependent photoelectron diffraction to investigate magnetic ultrathin films will be demonstrated, using our preliminary spectra of the multiplet-split Fe3s os near-monolayer Fe/Cu(001). 18 refs., 10 figs.

  10. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    Friebe, Jan; Pape, André; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M.; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several ...

  11. Atomic scattering in the diffraction limit: electron transfer in keV Li+-Na(3s, 3p) collisions

    Poel, Mike van der; Nielsen, C.V.; Rybaltover, M.;

    2002-01-01

    We measure angle differential cross sections (DCS) in Li+ + Na --> Li + Na+ electron transfer collisions in the 2.7-24 keV energy range. We do this with a newly constructed apparatus which combines the experimental technique of cold target recoil ion momentum spectroscopy with a laser-cooled target...... quantum scattering amplitudes are derived by the eikonal method. The resulting angle-differential electron transfer cross sections and their diffraction patterns agree with the experimental level-to-level results over most scattering angles in the energy range....

  12. BOREAS Level-3p Landsat TM Imagery: Geocoded and Scaled At-sensor Radiance

    Nickeson, Jaime; Knapp, David; Newcomer, Jeffrey A.; Hall, Forrest G. (Editor); Cihlar, Josef

    2000-01-01

    For BOReal Ecosystem-Atmosphere Study (BOREAS), the level-3p Landsat Thematic Mapper (TM) data were used to supplement the level-3s Landsat TM products. Along with the other remotely sensed images, the Landsat TM images were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy, detailed land cover, and biophysical parameter maps such as Fraction of Photosynthetically Active Radiation (FPAR) and Leaf Area Index (LAI). Although very similar to the level-3s Landsat TM products, the level-3p images were processed with ground control information, which improved the accuracy of the geographic coordinates provided. Geographically, the level-3p images cover the BOREAS Northern Study Area (NSA) and Southern Study Area (SSA). Temporally, the four images cover the period of 20-Aug-1988 to 07-Jun-1994. Except for the 07-Jun-1994 image, which contains seven bands, the other three contain only three bands.

  13. Comparative investigation of the c(2 Multiplication-Sign 2)-Si/Cu(0 1 1) and ({radical}3 Multiplication-Sign {radical}3)R30 Degree-Sign -Cu{sub 2}Si/Cu(1 1 1) surface alloys using DFT

    Shuttleworth, I.G., E-mail: shuttleworth.ian@gmail.com [Jubail University College, Jubail Industrial City 31961 (Saudi Arabia)

    2012-02-01

    The electronic structure of the c(2 Multiplication-Sign 2)-Si/Cu(0 1 1) surface alloy has been investigated and compared to the structures seen in the three phases of the ({radical}3 Multiplication-Sign {radical}3)R30 Degree-Sign Cu{sub 2}Si/Cu(1 1 1) system, using LCAO-DFT. The weighted surface energy increase between the alloyed Cu(0 1 1) and Cu(1 1 1) surfaces is 126.7 meV/Si atom. This increase in energy for the (0 1 1) system when compared to the (1 1 1) system is assigned to the transition from a hexagonal to a rectangular local bonding environment for the Si ion cores, with the hexagonal environment being energetically more favorable. The Si 3s state is shown to interact covalently with the Cu 4s and 4p states whereas the Si 3p state, and to a lesser extent the Si 3d state, forms a mixture of covalent and metallic bonds with the Cu states. The Cu 4s and 4p states are shown to be altered by approximately the same amount by both the removal of Cu ion cores and the inclusion of Si ion cores during the alloying of the Cu(0 1 1) surface. However, the Cu 3d states in the surface and second layers of the alloy are shown to be more significantly altered during the alloying process by the removal of Cu ion cores from the surface layer rather than by the addition of Si ion cores. This is compared to the behavior of the Cu 3d states in the surface and second layers of the each phase of the ({radical}3 Multiplication-Sign {radical}3)R30 Degree-Sign -Cu{sub 2}Si/Cu(1 1 1) alloy and consequently the loss of Cu-Cu periodicity during alloying of the Cu(0 1 1) surface is conjectured as the driving force for changes to the Cu 3d states. The accompanying changes to the Cu 4s and 4p states in both the c(2 Multiplication-Sign 2)-Si/Cu(0 1 1) and ({radical}3 Multiplication-Sign {radical}3)R30 Degree-Sign -Cu{sub 2}Si/Cu(1 1 1) alloys are quantified and compared. The study concludes with a brief quantitative study of changes in the bond order of the Cu-Cu bonds during alloying of

  14. $^3P_2$ Superfluids Are Topological

    Mizushima, Takeshi

    2016-01-01

    We clarify the topology of the $^3P_2$ superfluidity which is expected to be realized in the cores of neutron stars and cubic odd-parity superconductors. The phase diagram includes the unitary uniaxial/biaxial nematic phases and nonunitary ferromagnetic and cyclic phases. We here show that the low-energy structures of all the phases are governed by different types of topologically protected gapless fermionic excitations: Surface Majorana fermions in nematic phases, single itinerant Majorana fermion in the ferromagnetic phase, and a quartet of itinerant Majorana fermions in the cyclic phase. Using the superfluid Fermi liquid theory, we also demonstrate that dihedral-two and -four biaxial nematic phases are thermodynamically favored in the weak coupling limit under a magnetic field. The mass acquisition of surface Majorana fermions in nematic phases is subject to symmetry.

  15. Crystal structure of ∼RCu3S3 and ∼RCuTe2 (R=Gd-Lu) compounds

    Gulay, L. D.; Daszkiewicz, M.; Shemet, V. Ya.

    2012-02-01

    The crystal structures of ternary compounds TbCu3S3, Dy1.06Cu2.84S3 (space group R3¯), Ho0.67Cu2S2 (space group P3¯m1), ErCu3S3 (space group P3¯1c), Yb0.80Cu1.60S2, Lu0.67Cu2S2, TbCuTe2, DyCuTe2, Tm1.07Cu0.78Te2, LuCuTe2 (space group P3¯m1), Gd0.75Cu1.74Te2 (space group P3¯1m) were determined by means of X-ray single crystal diffraction. The S(Te) atoms are stacked in a close packed arrangement with the layers in the sequence AB. The R atoms are distributed over octahedral interstices whereas Cu atoms are located in tetrahedral interstices. Disorder of R and Cu atoms in studied chalcogenides is found. Crystal structure comparison showed that TbCuTe2 and DyCuTe2 crystallize as superstructure 2a×2a×2c to CaAl2Si2 structure type, whereas Gd0.75Cu1.74Te2, ErCu3S3 and TbCu3S3 (Dy1.06Cu2.84S3) have superstructure √3a×√3a×nc with n=1, 2, 3.

  16. Helium 3 3S decay rates in a high-pressure afterglow

    We report a total collisional quenching rate of (6.4 +- 0.3) x 10-12 cm3 sec-1 at 292 0K (or a thermally averaged cross section of 0.36 x 10-16 cm2) for He 3 3S atoms colliding with ground-state He atoms. This rate is determined by using a pulsed dye laser to populate the 3 3S level in a He aftergow and then observing the decay of the 3 3S → 2 3P fluorescence. We see no evidence for three-body collisional quenching of 3 3S atoms at pressures up to 300 Torr

  17. Fine-structure energy levels, oscillator strengths and lifetimes in Cu XVI

    We have performed large-scale CIV3 calculations of excitation energies from ground state for 69 fine-structure levels as well as of oscillator strengths and radiative decay rates for all electric-dipole-allowed and intercombination transitions among the fine-structure levels of the terms belonging to the (1s22s22p6)3s23p2, 3s3p3, 3p4, 3s23p3d, 3s23p4s, 3s23p4p, 3s23p4d, and 3s23p4f configurations of Cu XVI. These states are represented by very extensive configuration-interaction (CI) wave functions obtained with the computer code CIV3 of Hibbert. The important relativistic effects in intermediate coupling are incorporated by means of the Breit-Pauli Hamiltonian. Small adjustments to the diagonal elements of the Hamiltonian matrices have been made so that the energy splittings are as close as possible to the energy values of those from the National Institute for Standards and Technology. The mixing among several fine-structure levels is found to be very strong. From our radiative decay rates we have also calculated radiative lifetimes of the fine-structure levels. Our calculated lifetime for the high spin level 3s3p3(5S2) is found to be in excellent agreement with the experimental value of Trabert et al (1988 J. Opt. Soc. Am. B 5 2173). In this calculation, we also predict new data for several fine-structure levels where no other theoretical and/or experimental results are available.

  18. Irradiation-induced softening of Ni3P and (Ni, Fe, Cr)3P alloys

    Production of amorphous alloys by solid state reactions (SSR) has attracted much interest during the last few years. One of the methods to induce such a reaction is the irradiation of suitable crystalline alloys by fast particles. Examination of this kind of SSR in M3P type of brazing alloys (M: Metal) is attractive because of the following reason: In brazed joints of candidate structural materials like 316L stainless steel for applications in fusion reactors, crystalline intermetallic phases have been detected which are unstable relative to the amorphous state when irradiated at moderate temperatures with fast particles. It is expected that the transition to the amorphous state is accompanied by changes of the mechanical properties, which are of fundamental interest in this context. Until now, only a few studies on the evolution of mechanical properties during amorphization have been performed. Measurements of microhardness of the crystalline and the corresponding amorphous phase do not exist to the authors knowledge. In this communication, the authors present results on changes of microhardness, due to amorphization by fast ions. The measurements have been performed on a model alloy Ni3P and on the brazed joint of stainless steel 316L, containing M3P (M: Ni, Fe, Cr) as one of the phases. Though microhardness is not a fundamental property of materials, it is a manifestation of several related properties, such as yield stress, ductility, work-hardening, elastic modulus and residual stress states. It represents a resistance for indentation and is, therefore, appropriate for comparative purposes

  19. Spectra and oscillator strengths of 3p63d9-3p53d10 and 3p63d9-3p63d84p transitions for cobalt-like Sn23+ ion

    Chen Ming-Lun; Yu Xiao-Guang

    2009-01-01

    This paper calculates the spectra and oscillator strengths for highly ionized cobalt-like Sn23+ ions 3p63d9-3p53d10,3p63d9 - 3p63d84p transitions by using a multi-configuration self-consistent field method program together with the proposed fitting formula. The calculations have a good agreement with observations.

  20. Photoemission time-delay measurements and calculations close to the 3s ionization minimum in Ar

    Guenot, D; Arnold, C L; Kroon, D; Dahlstrom, J M; Miranda, M; Fordell, T; Gisselbrecht, M; Johnsson, P; Mauritsson, J; Lindroth, E; Maquet, A; Taieb, R; L'Huillier, A; Kheifets, A S

    2012-01-01

    We present experimental measurements and theoretical calculations of photoionization time delays from the $3s$ and $3p$ shells in Ar in the photon energy range of 32-42 eV. The experimental measurements are performed by interferometry using attosecond pulse trains and the infrared laser used for their generation. The theoretical approach includes intershell correlation effects between the 3s and 3p shells within the framework of the random phase approximation with exchange (RPAE). The connection between single-photon ionization and the two-color two-photon ionization process used in the measurement is established using the recently developed asymptotic approximation for the complex transition amplitudes of laser-assisted photoionization. We compare and discuss the theoretical and experimental results especially in the region where strong intershell correlations in the 3s to kp channel lead to an induced "Cooper" minimum in the 3s ionization cross-section.

  1. Differential cross section of metastable Ne(3P0 and 3P2) scattered from ground state neon

    The differential elastic cross section for metastable Ne(3P0 and 3P2) from ground state Ne at collision energies between 70 and 150 meV have been measured. With a CW-dye laser it was possible to separate the cross sections for Ne(3P0) + Ne and Ne(3P2) + Ne and for the energy exchange process 20Ne* + 22Ne → 20Ne + 22Ne*. (Auth.)

  2. Differential cross section for Ne(3P0) and Ne(3P2) scattered from ground state neon

    The differential elastic cross sections for electronically excited Ne(3P0) and Ne(3P2) from ground state neon atoms at thermal collision energies have been measured separately. Potentials for Ne(3P0)+Ne could be determined and the height of the intermediate potential maxima for Ne(3P2)+Ne could be estimated to 25 meV. By preparing Ne(3P2) in special Msub(J) states scattering in single Ω molecular states could be observed. (Auth.)

  3. Differential cross section for Ne(3P0) and Ne(3P2) scattered from ground state neon

    The differential elastic cross sections for electronically exited Ne(3P0) and Ne(3P2) from ground state neon atoms at thermal collision energies have been measured separately. Potentials for Ne(3P0)+Ne could be determined and the height of the intermediate potential maxima for Ne(3P2)+Ne could be estimated to 25 meV. By preparing Ne(3P2) in special Msub(J) states scattering in single Ω molecular states could be observed. (Author)

  4. Resonant inverse photoemission study of late transition metals at 3p absorption edge

    Full text: Resonant inverse photoemission spectra (RIPES) of late transition metals (TM) were observed near TM 3p absorption edge. The RIPES spectra of polycrystalline Co, Ni and Cu, as well as single crystal Ni, were observed. Figure 1 shows resonant IPES spectra of polycrystalline Co, Ni and Cu, which were prepared by evaporation. These spectra ware excited by energy above 3p absorption edge (off-resonance). Since a core hole is created by these energies, TM 3d → 3p fluorescence peak is observed in each spectrum at high energy, which is indicated by vertical bars. The main peak just above EF is TM 3d structure, while TM 4sp is observed at 10 ∼ 15 eV. In resonant spectra, the 3d structure changes its intensity, while the 4sp structure does not. In case of Ni metal, satellite structures are also observed at about 2 and 4 eV. From a calculation by Tanaka and Jo, which is based on the Anderson impurity model, the observation of satellite structures suggests the 10 ∼ 20 % 3d8 in ground state The RIPES spectra in this study give us a direct evidence of 3d8 component in Ni metal

  5. Absence of hydrogen in superconducting molybdenum sulfide, Mo 3S 4

    Baillif, R.; Yvon, K.; Fischer, P.

    1983-09-01

    Superconducting Mo 3S 4( Tc=1.8 K) was prepared from the ternary sulfides MMo 3S 4 ( M=Cu, Ni) by the acid extraction method, and was studied by neutron diffraction and NMR spectroscopy. In contrast to earlier reports no significant amounts of hydrogen could be found in the rhombohedral structure. However, large proton concentrations were found in samples which had been exposed to moist air.

  6. Absence of hydrogen in superconducting molybdenum sulfide, Mo3S4

    Superconducting Mo3S4 (Tsub(c)=1.8 K) was prepared from the ternary sulfides MMo3S4 (M = Cu, Ni) by the acid extraction method, and was studied by neutron diffraction and NMR spectroscopy. In contrast to earlier reports no significant amounts of hydrogen could be found in the rhombohedral structure. However, large proton concentrations were found in samples which had been exposed to moist air. (author)

  7. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    Friebe, Jan; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several other optical transitions from $^1S_0$ to the $^3P_J$-level system for $^{24}$Mg, $^{25}$Mg and $^{26}$Mg. We describe in detail the components of our optical frequency standard like the stabilized spectroscopy laser, the atomic beam apparatus used for Ramsey-Bord\\'e interferometry and the frequency comb generator and discuss the uncertainty contributions to our measurement including the first and second order Doppler effect. An upper limit of $3\\times10^{-13}$ in one second for the short term instability of our optical f...

  8. Is Y(4008) possibly a 1{sup --} ψ(3{sup 3}S{sub 1}) state?

    Chen, Li-Jin; Zhang, Ailin [Shanghai University, Department of Physics, Shanghai (China); Ye, Dan-Dan [Shanghai University, Department of Physics, Shanghai (China); Jiaxing University, College of Mathematics, Physics and Information Engineering, Jiaxing (China)

    2014-08-15

    The strong decays of the radially excited ψ(3{sup 3}S{sub 1}) state are studied within the 3P0 model. As a believed ψ(3{sup 3}S{sub 1}), some strong decay widths and relevant ratios of ψ(4040) are calculated in the model. In a similar way, as a possible ψ(3{sup 3}S{sub 1}), the same strong decay widths and relevant ratios of Y(4008) are presented. Our study indicates that Y (4008) is hard to be identified with a ψ(3{sup 3}S{sub 1}) charmonium once it is confirmed under the D{sup *} anti D{sup *} threshold, but it is possibly a ψ(3{sup 3}S{sub 1}) charmonium once it is confirmed above the D{sup *} anti D{sup *} threshold by experiment. (orig.)

  9. Cooling of Neutron Stars and 3P_2 neutron gap

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``Nuclear medium cooling scenario'' is in favor of a suppressed value of the $3P_2$ neutron gap.

  10. 3p - 3d intershell interaction in Cr

    The photoemission of Cr films deposited under UHV conditions has been investigated in the photon energy range from 30 eV to 230 eV. The 3p - 3d intershell interaction gives rise to a strong maximum in the 3d partial yield above the 3p threshold. (orig.) 891 KBE/orig. 892 RDG

  11. Assessment of combined toxicity of heavy metals from industrial wastewaters on Photobacterium phosphoreum T3S

    Zeb, BibiSaima; Ping, Zheng; Mahmood, Qaisar; Lin, Qiu; Pervez, Arshid; Irshad, Muhammad; Bilal, Muhammad; Bhatti, Zulfiqar Ahmad; Shaheen, Shahida

    2016-02-01

    This research work is focusing on the toxicities of heavy metals of industrial origin to anaerobic digestion of the industrial wastewater. Photobacterium phosphoreum T3S was used as an indicator organism. The acute toxicities of heavy metals on P. phosphoreum T3S were assessed during 15-min half inhibitory concentration (IC50) as indicator at pH 5.5-6. Toxicity assays involved the assessment of multicomponent mixtures using TU and MTI approaches. The results of individual toxicity indicated that the toxicity of Cd, Cu and Pb on P. phosphoreum increased with increasing concentrations and there was a linear correlation. The 15-min IC50 values of Cd, Cu and Pb were 0.537, 1.905 and 1.231 mg/L, respectively, and their toxic order was Cd > Pb > Cu. The combined effects of Cd, Cu and Pb were assayed by equivalent concentration mixing method. The results showed that the combined effects of Cd + Cu, Cd + Pb, Cu + Pb, Cd + Cu + Pb were antagonistic, antagonistic and partly additive. The combined effect of three heavy metals was partly additive.

  12. The state dependence of the interaction of metastable rare gas atoms Rg sup * (ms sup 3 P sub 2 , sup 3 P sub 0 ) (Rg=Ne, Ar, Kr, Xe) with ground state sodium atoms

    Schohl, S.; Mueller, M.W.; Meijer, H.A.J.; Ruf, M.W.; Hotop, H. (Kaiserslautern Univ. (Germany, F.R.). Fachbereich Physik); Morgner, H. (Witten-Herdecke Univ., Witten (Germany, F.R.). Inst. fuer Experimentalphysik)

    1990-08-01

    Using crossed beams of metastable rare gas atoms Rg{sup *}(ms {sup 3}P{sub 2}, {sup 3}P{sub 0}) (Rg=Ne, Ar, Kr, Xe) and ground state sodium atoms Na(3s {sup 2}S{sub 1/2}), we have measured the energy spectra of electrons released in the respective Penning ionization processes at thermal collision energies. For Rg{sup *}({sup 3}P{sub 2})+Na(3s), the spectra are quite similar for the different rare gases, both in width and shape; they reflect attractive interactions in the entrance channel with well depths D{sub e}{sup *} (meV) decreasing slowly from Rg=Ne to Xe as follows: 676(18); 602(23); 565(26); 555(30). For Rg{sup *}({sup 3}P{sub 0})+Na(3 s), the spectra vary strongly with the rare gas, indicating a change in the character of the interaction from van der Waals type attraction (Ne) to chemical binding for Kr and Xe with well depths D{sub e}{sup *} (meV) of: 51(19); 107(25); 432(30); 530(50). These findings are explained through model calculations of the respective potential curves, in which the exchange and the spin orbit interaction in the excited rare gas and the molecular interaction between the two valence s-electrons in terms of suitably chosen singlet and triplet potentials are taken into account. These calculations also explain qualitatively the experimental finding that the ratios q{sub 2}/q{sub 0} of the ionization cross sections for Rg{sup *}({sup 3}P{sub 2})+Na and Rg{sup *}({sup 3}P{sub 0})+Na vary strongly with the rare gas from Ne to Xe as follows: 15.8(3.2); 2.6(4); 1.4(2); 1.6(4). (orig.).

  13. Chromosome 3p alterations in pancreatic endocrine neoplasia

    Amato, Eliana; Barbi, Stefano; Malpeli, Giorgio; Bersani, Samantha; Pelosi, Giuseppe; Capelli, Paola

    2010-01-01

    Pancreatic endocrine tumors (PET) are rare neoplasms classified as functioning (F-PET) or non-functioning (NF-PET) according to the presence of a clinical syndrome due to hormonal hypersecretion. PETs show variable degrees of clinical aggressiveness and loss of chromosome 3p has been suggested to be associated with an advanced stage of disease. We assessed chromosome 3p copy number in 113 primary PETs and 32 metastases by fluorescence in situ hybridization (FISH) using tissue microarrays. The series included 56 well-differentiated endocrine tumors (WDET), 62 well-differentiated endocrine carcinomas (WDEC), and 6 poorly differentiated endocrine carcinomas (PDEC). Chromosome 3p alterations were found in 23/113 (20%) primary tumors, with losses being predominant over gains (14% vs. 6%). Loss of 3p was found in 5/55 (9%) WDET, 11/52 (21%) WDEC, and never in PDEC. Gains of 3p were detected in 4/55 (7%) WDET, no WDEC, but notably in 3/6 (50%) PDEC (OR 23.6; P = 0.003). Metastases were more frequently monosomic for 3p compared to primary tumors (OR 3.6; P = 0.005). Monosomy was significantly associated with larger tumor size, more advanced tumor stage, and metastasis. No association was found with survival. Chromosome 3p copy number alterations are frequent events in advanced stage PET, with gains prevailing in PDEC while losses are more frequent in WDEC, supporting the view that a specific pattern of alterations are involved in these diverse disease subtypes. PMID:20981439

  14. Safety, Security and Safeguards (3S) Culture

    A meaningful discussion of Safety, Security, and Safeguards (3S) Culture requires a review of the concepts related to the culture of the three components. The concept of culture can be confusing, and so careful use of terminology is needed to enable a focused and constructive dialogue. To this end, this paper will use the concept of organizational culture as a backdrop for a broader discussion about how the three subcultures of safety, security and safeguards come together to enhance the mission of an organization. Since the accidents at Three Mile Island and Chernobyl, the nuclear industry has embraced the concept of safety culture. The work on safety culture has been used to develop programs and concepts in the culture of Material Protection, Control, and Accounting and Nuclear Security Culture. More recently, some work has been done on defining an International Safeguards Culture. Others have spoken about a 3S Culture, but there has been little rigorous consideration of the concept. This paper attempts to address 3S Culture, to begin to evaluate the merit of the concept, and to propose a definition. The paper is followed by the slides of the presentation. (authors)

  15. Vaporization of In2Te3(s)

    The vaporization chemistry of In2Te3(s) was studied by the computerautomated simultaneous Knudsen-effusion and torsion-effusion method, by high-temperature mass spectrometry, and by ancillary methods. The first absolute measurements of the vapor pressure of In2Te3 are reported. In2Te3(s) vaporized incongruently in the temperatue range 701-889 K and produced Te2(g) and a solid-solution, (Xsub(In)=0.42 and Xsub(Te)=0.58). The standard enthalpy of the reaction at 298 K, ΔH0 (298 K) by the third-law method was 136.0 +- 0.3 kJ/mol of vapor. The above solid solution vaporized incongruently and produced in InTe(s) and a vapor which consisted of Te2(g) and In2Te(g). InTe(s) vaporized congruently in the range 701-887 K and produded Te2(g) and In2Te(g); the third-law ΔH0sub(ν) (298 K) was 201.5 +- 1.0 kJ/mol. These results were at variance with the literature on vaporization of In2Te3(s) where both congruent vaporization and incongruent vaporization to give InTe(s) are separately reported. Further, InTe(s) was reported to vaporize incongruently. These differences are discussed. (Author)

  16. Band structure and electron-phonon coupling in H3S : A tight-binding model

    Ortenzi, L.; Cappelluti, E.; Pietronero, L.

    2016-08-01

    We present a robust tight-binding description, based on the Slater-Koster formalism, of the band structure of H3S in the Im3 ¯m structure, stable in the range of pressure P =180 -220 GPa. We show that the interatomic hopping between the 3 s and 3 p orbitals (and partially between the 3 p orbitals themselves) of sulfur is fundamental to capturing the relevant physics associated with the Van Hove singularities close to the Fermi level. Comparing the model so defined with density functional theory calculations we obtain a very good agreement not only of the overall band structure but also of the low-energy states and the Fermi surface properties. The description in terms of Slater-Koster parameters permits us also to evaluate at a microscopic level a hopping-resolved linear electron-lattice coupling which can be employed for further tight-binding analyses also at a local scale.

  17. P3P semantic checker of site behaviours

    Grande, Robson Eduardo; Zorzo, Sérgio Donizetti

    2006-01-01

    The interactive use of the web between users and service providers introduces a privacy problem that involves the undesired disclosing of user personal information, mainly with the presence of personalization that needs this type of information. Also there are many manners to face it, but the Platform for Privacy Preferences (P3P) is one that provides a variable level of privacy for the user’s browsing. However, the P3P only introduces a privacy contract between the site and the user, without...

  18. MAP3S precipitation chemistry network: seventh periodic summary report, 1983. [MAP3S Network

    Rothert, J.E.; Dana, M.T.

    1984-11-01

    This summary report, the seventh in the series, contains complete field and chemical data from the MAP3S Precipitation Chemistry Network for the year 1983. Sections cover QA/QC of the MAP3S/PCN; network history, network site information and a MAP3S/PCN bibliography; and a brief statistical look at the laboratory operations for 1983. There is also a brief statistical summary for 1982 to 1983. Included under the Quality Control section are the QA audits for site performance, laboratory comparisons, field blank and pH test results, and sample shipping and analysis results. Included is a listing of cooperating organizations and personnel for the MAP3S/PCN. 10 references, 10 figures, 32 tables.

  19. A developmental toxicity study of 3S, 3'S-Astaxanthin in New Zealand white rabbits.

    Schneider, Steffen; Mellert, Werner; Schulte, Stefan; van Ravenzwaay, Bennard

    2016-04-01

    Astaxanthin, a naturally occurring pigment used to give the characteristic orange-pink colour to salmonid fish reared in aquaculture, is also marketed as a dietary supplement. Synthetic 3S, 3'S-Astaxanthin was tested for potential harmful effects on the in utero development of New Zealand white rabbits in a study according to international regulatory guidelines. There were two control groups, one being a placebo administration and three dose levels corresponding to 100, 200, and 400 mg of 3S, 3'S-Astaxanthin per kg body weight/day. The group sizes varied from 23 to 27 litters, providing approximately 200 fetuses per group for evaluation of developmental toxicity. There were no significant effects on the health of the does, nor on the size and viability of the litters. Malformations, both external and internal, were rare and occurred in all groups, including controls with no indication of a treatment relationship. Variations were much more common, being found in all litters. However, when examined by type and frequency, no pattern emerged indicating a relationship to administration of the test substance. It is concluded that administration of 3S, 3'S-Astaxanthin in a gelatin/carbohydrate powder formulation throughout pregnancy up to 400 mg/kg body weight/day is without harmful effects on reproduction or fetal development. PMID:26854919

  20. Dsj meson decay in the C3P0 model

    Full text. Fock-Tani is a field theory formalism appropriated for the simultaneous treatment of composite particles and their constituents. The formalism was originally developed for the treatment of problems in atomic physics and it was extended later on to the treatment of problems on hadron physics. In the Fock-Tani formalism one starts with the Fock representation of the system using field operators of elementary constituents which satisfy canonical (anti) commutation relations. Composite-particle field operators are linear combinations of the elementary-particle operators and do not generally satisfy canonical (anti) commutation relations. 'Ideal' field operators acting on an enlarged Fock space are then introduced in close correspondence with the composite ones. Next, a given unitary transformation, which transforms the single composite states into single ideal states, is introduced. Application of the unitary operator on the microscopic Hamiltonian, or on other hermitian operators expressed in terms of the elementary constituent field operators, gives equivalent operators which contain the ideal field operators. The effective Hamiltonian in the new representation has a clear physical interpretation in terms of the processes it describes. Since all field operators in the new representation satisfy canonical (anti)commutation relations, the standard methods of quantum field theory can then be readily applied. For a long time the pair creation models for strong hadronic decays have been formulated. The 3P0 model is typical decay model which considers only OZI-allowed strong decays. The 3P0 model considers a quark-antiquark par creation in the presence of the initial state meson. The quark-antiquark par is created with the vacuum quantum numbers. This model can also be obtained from the non-relativistic limit of the pair creation Hamiltonian. Applying the Fock-Tani transformation to the pair creation Hamiltonian produces the characteristic expansion in powers of

  1. Ionic rotational branching ratios in resonant enhanced multiphoton ionization of NO via the A2Sigma(+)(3s sigma) and D2Sigma(+)(3p sigma) states

    Rudolph, H.; Mckoy, V.; Dixit, S. N.; Huo, W. M.

    1988-01-01

    Results are presented for the rotationally resolved photoelectron spectra resulting from a (2 + 1) one-color resonant enhanced multiphoton ionization (REMPI) of NO via the rotationally clean S21(11.5) and mixed S11(15.5) + R21(15.5) branches of the 0-0 transition in the D-X band. The calculations were done in the fixed-nuclei frozen core approximation. The resulting photoionization spectra, convoluted with a Lorentzian detection function, agree qualitatively with experimental results of Viswanathan et al. (1986) and support their conclusion that the nonspherical nature of the molecular potential creates a substantial l-mixing in the continuum, which in turn leads to the intense Delta N = 0 peak. The rather strong photoelectron energy dependence of the rotational branching ratios of the D 2Sigma(+) S21(11.5) line was investigated and compared to the weak energy dependence of the A 2Sigma(+) R22(21.5) line.

  2. Doubly excited 3P(e) resonant states in Ps(-)

    Ho, Y. K.; Bhatia, A. K.

    1992-01-01

    Doubly excited 3P(e) resonant states in Ps(-) are calculated using a method of complex-coordinate rotation. Resonance parameters (both resonance positions and widths) for doubly excited states associated with the n = 2, 3, 4, 5, and 6 thresholds of positronium atoms are evaluated using elaborate Hylleraas-type functions. In addition to ten Feshbach-type resonances lying below various Ps thresholds, three shape resonances were identified, one each lying above the n = 2, 4, and 6 Ps thresholds. It is further noted that the energy levels for the present 3P(e) states are nearly degenerate with respect to the previously calculated 1P(0) states. Such a symmetric character suggests that the highly and doubly excited Ps(-), similar to its counterpart in H(-), would exhibit rovibrational behaviors analogous to those of XYX triatomic molecules.

  3. Configuration interaction calculations of positron binding to Be(3P )

    The configuration interaction method is applied to investigate the possibility of positron binding to the metastable beryllium (1s22s2p 3P ) state. The largest calculation obtained an estimated energy that was unstable by 0.00014 Hartree with respect to the Ps + Be+(2s) lowest dissociation channel. It is likely that positron binding to parent states with non-zero angular momentum is inhibited by centrifugal barriers

  4. Spatial and electronic structure of the Ni3P surface

    To understand the catalytic effect in the Ni-Ni3P for the growth of carbon nanostructures, the structural and electronic properties of Ni3P surface are calculated from first-principles calculations. The calculated surface energies for the (0 0 1)-Ni4P4-terminated surface, the (0 0 1)-Ni8-terminated surface, and the (1 1 0)-Ni8-terminated surface show that the (0 0 1)-Ni4P4-terminated surface is energetically more stable within the allowed range of the chemical potential of P. Through the analysis of the partial density of states of Ni and P atoms in surface and bulk states, respectively, it is further found that due to the bond contractions of the surface layer, the core-level shifts of P atoms in the (0 0 1)-Ni4P4-terminated surface make P atoms in the Ni3P particles act as a catalyst. Finally, the obtained results of the work function show that the (0 0 1)-Ni4P4-terminated surface has the largest work function when compared with the other two studied surfaces.

  5. Hyperfine Quenching of the 2s2p 3P0 State of Berylliumlike Ions

    Cheng, K T; Chen, M H; Johnson, W R

    2008-03-13

    The hyperfine-induced 2s2p {sup 3}P{sub 0}-2s{sup 2} {sup 1}S{sub 0} transition rate for Be-like {sup 47}Ti{sup 18+} was recently measured in a storage-ring experiment by Schippers et al. [Phys. Rev. Lett. 98, 033001 (2007)]. The measured value of 0.56(3) s{sup -1} is almost 60% larger than the theoretical value of 0.356 s{sup -1} from a multiconfiguration Dirac-Fock calculation by Marques et al. [Phys. Rev. A 47, 929 (1993)]. In this work, we use a large-scale relativistic configuration-interaction method to calculate these hyperfine-induced rates for ions with Z = 6-92. Coherent hyperfine-quenching effects between the 2s2p {sup 1,3}P{sub 1} states are included in a perturbative as well as a radiation damping approach. Contrary to the claims of Marques et al., contributions from the {sup 1}P{sub 1} state are substantial and lead to a hyperfine-induced rate of 0.67 s{sup -1}, in better agreement with, though larger than, the measured value.

  6. The deexcitation of the Ar (3P2, 3p1 and 1P1) states as measured by absorption both in pure argon and in the presence of additives

    The de-excitation of the 3P2, 3p1 and 1P1 states of argon was studied in pure argon between 10 and 200 torr and in Ar + CO and Ar + H2 mixtures. These states are populated after excitation of the gas by a short (20 ns) pulse of 500 keV electrons (FEBETRON). Under our experimental conditions, the relation between the measured optical density of the lines studied and the concentration of absorbing species was found to be: DO = log I0/I ∝ (lC)n with n = 0,4. The three body rate constants k2 were measured for the two resonant states 3p1 (k2 = (1,65 ± 0,3) x 10-32 cm6 s-1) and 1P1 (k2 = (1,0 ± 0,2) x 10-32 cm6 s-1); they had not been considered in previous low pressure studies. For the metastable state 3P2, the measured value of k2 ((1,6 ± 0,3) x 10-32 cm6 s-1) is in good agreement with those found in the literature. However, our two body rate constant k1 is about ten times higher than that found in measurements at low pressure. This difference could be due to a collision-induced emission process at high pressure. The rate constants for the quenching by CO and H2 were measured for the metastable state 3P2 (1,85 and 10,5 x 10-11 cm3 s-1) and for the resonant states 3P1 (4,5 and 20 x 10-11 cm3 s-1) and 1P1 (8,5 and 33 X 10-11 cm3 s-1). Comparison of the de-excitation cross sections of resonant and metastable states should lead to a better understanding of energy transfer processes from these latter. (author)

  7. Einstein A-coefficients for transitions among the 3s23p3 states of S II

    Einstein A-coefficients for transitions among the 3s23p3 states of S II, calculated with the CIV3 code, are found to be up to ∝ 25% different from those of Mendoza and Zeippen. These new results are used to derive the theoretical emission line ratio R = I(3s23p34So3/2-3s2 3p32Do5/2)/I(3s33p34So3/2-3s23p32Do3/2) = I(6717 A)/I(6730 A), which is a very useful electron density diagnostic for gaseous nebulae. The present diagnostics are up to ∝ 10% larger than those deduced using the A-values of Mendoza and Zeippen, and will lead to electron density estimates up to ∝ 50% greater. (orig.)

  8. Thermodynamic properties of SrMoO3(s) and BaMoO3(s)

    Enthalpy increment measurements for SrMoO3(s) and BaMoO3(s) have been carried out using a high temperature Calvet drop calorimeter. The data were least squares fitted using the constraints that Cpo(298.15 K) values are from literature and Ho(T)-Ho(298.15 K) at 298.15 K equals zero. The enthalpy increment values for SrMoO3(s) and BaMoO3(s) can be given, respectively, by the following equations: Ho(T) - Ho(298.15 K) (J/mol) 123.2 T(K) + 8.092x10-3 T2(K) + 19.998x105/T(K) - 44162 (426 to 1011 K). Ho(T) - Ho(298.15 K)(J/mol) = 132.72 T(K) + 7.3646x10-3 T2 (K) + 27.696x 105/T(K) - 49539 (478 to 1011 K). The first differential of the above equations with respect to temperature gives Cpo(T). Other thermal properties were then derived. (author). 7 refs., 2 tabs

  9. Experimental and theoretical studies of isomeric CH3S2 and CH3S+2

    By combining molecular beam photodissociation and photoionization measurements with ab initio Gaussian-2 (G2) calculations on the CH3S2 and CH3S+2 systems, we have shown that CH3SS is the dominant isomer formed in the photodissociation process, CH3SSCH3+hν(193 nm) →CH3S2+CH3. The experimental ionization energy for CH3SS (8.97±0.02 eV) and the heat of formation at 0 K for CH3SS+ (217.7±1.2 kcal/mol) are in excellent agreement with the G2 results. The photoionization efficiency spectrum observed for CH3SS is also consistent with the theoretical prediction that the Franck--Condon factor for the photoionization process, CH3SS+hν →CH3SS++e-, is not favorable. Based on the statistical modeling of experimental rates obtained previously for HS loss in the unimolecular decomposition of CH3SSCH+3 and the comparison with G2 ab initio predictions, we conclude that CH2SSH+ is most likely the isomer structure formed near the experimental appearance energy (11.07 eV) observed for the photodissociative ionization process, CH3SSCH3+hν→CH3S+2+CH3+e-

  10. JS3P: junior staff programme pilot project

    Pretrel, H.; Tregoures, N.; Bessiron, V.; Dehoyos, A.; Delvallee, I.; Brisson, N.; Debayle, C.; Dubreuil, M.; Nicaise, G.; Perignon, J.P.; Richard, J. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 13 - Saint-Paul-lez-Durance (France); Reinke, N.; Kaulard, J.; Burgener, M.; Keesmann, S.; Schramm, B.; Seubert, A.; Sternkopf, J.; Thuma, G.; Weber, S. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Koln (Germany); Smidts, O.; Maillet, E.; Bucalossi, A.; Van haesendonck, M.; Uyttenhove, W.; Mertens, J. [AVN, Bruxelles (Belgium)

    2006-07-01

    Concept: The objective of the project is to allow junior staff members from the European Technical Safety Organisations (TSOs), IRSN, GRS and AVN, to work together with the final goal of creating a junior staff network, based on technical, cultural and personal interests. These projects are to show junior staff members at a very early stage during their career the need for European collaborations. They are also a tool to explore new subjects of co-operation. It is an initiative that should strengthen the links between the organisations and contribute to establishing the future of nuclear safety in Europe. A JS3P (Junior Staff Programme Pilot Project) is a project done jointly by 'junior' staff members from the three TSOs, where experience of 'seniors' is also integrated when needed. Compared to other collaborative activities, it has certain specific features. The JS3P favours staff exchanges, and technical meetings of several days should be planned during a project in order to encourage people to work together. Technical objectives are shared and the work is done jointly (reports, articles). The team involved in the JS3P should be as small as possible to favour its efficiency. The JS3P is short and easy to realize. Its duration is fixed to a maximum of about 12 months with the option to be prolonged. Typical topics are bibliographic work, comparison issues, scientific surveys, benchmark exercises and prospective investigations on innovative ideas. They can be linked to existing joint projects and then form a smaller module integrated into the large project. Topics may concern prospective issues, tentatively investigating new topics that can be seen as exploratory co-operation projects. Subjects may also concern research issues that are not a priority but that deserve to be investigated as new attractive topics. The JS3P is defined and managed by junior staff members. It is approved by a management board committee and supervised by a technical

  11. JS3P: junior staff programme pilot project

    Concept: The objective of the project is to allow junior staff members from the European Technical Safety Organisations (TSOs), IRSN, GRS and AVN, to work together with the final goal of creating a junior staff network, based on technical, cultural and personal interests. These projects are to show junior staff members at a very early stage during their career the need for European collaborations. They are also a tool to explore new subjects of co-operation. It is an initiative that should strengthen the links between the organisations and contribute to establishing the future of nuclear safety in Europe. A JS3P (Junior Staff Programme Pilot Project) is a project done jointly by 'junior' staff members from the three TSOs, where experience of 'seniors' is also integrated when needed. Compared to other collaborative activities, it has certain specific features. The JS3P favours staff exchanges, and technical meetings of several days should be planned during a project in order to encourage people to work together. Technical objectives are shared and the work is done jointly (reports, articles). The team involved in the JS3P should be as small as possible to favour its efficiency. The JS3P is short and easy to realize. Its duration is fixed to a maximum of about 12 months with the option to be prolonged. Typical topics are bibliographic work, comparison issues, scientific surveys, benchmark exercises and prospective investigations on innovative ideas. They can be linked to existing joint projects and then form a smaller module integrated into the large project. Topics may concern prospective issues, tentatively investigating new topics that can be seen as exploratory co-operation projects. Subjects may also concern research issues that are not a priority but that deserve to be investigated as new attractive topics. The JS3P is defined and managed by junior staff members. It is approved by a management board committee and supervised by a technical steering committee

  12. Highly charged swelling mica reduces Cu bioavailability in Cu-contaminated soils

    This is the first test of a highly charged swelling mica's (Na-2-mica) ability to reduce the plant-absorbed Cu in Cu-contaminated soils from Chile. Perennial ryegrass (Lolium perenne L.) was grown in two acid soils (Sector 2: pH 4.2, total Cu = 172 mg Cu kg-1 and Sector 3: pH 4.2, total Cu = 112 mg Cu kg-1) amended with 0.5% and 1% (w/w) mica, and 1% (w/w) montmorillonite. At 10 weeks of growth, both mica treatments decreased the shoot Cu of ryegrass grown in Sector 2 producing shoot Cu concentrations above 21-22 mg Cu kg-1 (the phytotoxicity threshold for that species), yet the mica treatments did not reduce shoot Cu concentrations when grown in Sector 3, which were at a typical level. The mica treatments improved shoot growth in Sector 3 by reducing free and extractable Cu to low enough levels where other nutrients could compete for plant absorption and translocation. In addition, the mica treatments improved root growth in both soils, and the 1% mica treatment reduced root Cu in both soils. This swelling mica warrants further testing of its ability to assist re-vegetation and reduce Cu bioavailability in Cu-contaminated surface soils. - In situ remediation of Cu-contaminated soils with a synthetic mica (Na-2-mica) will aid in re-vegetative efforts

  13. Products of the Benzene + O(3P) Reaction

    Taatjes, Craig A.; Osborn, David L.; Selby, Talitha M.; Meloni, Giovanni; Trevitt, Adam J.; Epifanovsky, Evgeny; Krylov, Anna I.; Sirjean, Baptiste; Dames, Enoch; Wang, Hai

    2009-12-21

    The gas-phase reaction of benzene with O(3P) is of considerable interest for modeling of aromatic oxidation, and also because there exist fundamental questions concerning the prominence of intersystem crossing in the reaction. While its overall rate constant has been studied extensively, there are still significant uncertainties in the product distribution. The reaction proceeds mainly through the addition of the O atom to benzene, forming an initial triplet diradical adduct, which can either dissociate to form the phenoxy radical and H atom, or undergo intersystem crossing onto a singlet surface, followed by a multiplicity of internal isomerizations, leading to several possible reaction products. In this work, we examined the product branching ratios of the reaction between benzene and O(3P) over the temperature range of 300 to 1000 K and pressure range of 1 to 10 Torr. The reactions were initiated by pulsed-laser photolysis of NO2 in the presence of benzene and helium buffer in a slow-flow reactor, and reaction products were identified by using the multiplexed chemical kinetics photoionization mass spectrometer operating at the Advanced Light Source (ALS) of Lawrence Berkeley National Laboratory. Phenol and phenoxy radical were detected and quantified. Cyclopentadiene and cyclopentadienyl radical were directly identified for the first time. Finally, ab initio calculations and master equation/RRKM modeling were used to reproduce the experimental branching ratios, yielding pressure-dependent rate expressions for the reaction channels, including phenoxy + H, phenol, cyclopentadiene + CO, which are proposed for kinetic modeling of benzene oxidation.

  14. Photoinduced Kondo effect in CeZn3P3

    Kitagawa, J.; Kitajima, D.; Shimokawa, K.; Takaki, H.

    2016-01-01

    The Kondo effect, which originates from the screening of a localized magnetic moment by a spin-spin interaction, is widely observed in nonartificial magnetic materials, artificial quantum dots, and carbon nanotubes. In devices based on quantum dots or carbon nanotubes that target quantum information applications, the Kondo effect can be tuned by a gate voltage, a magnetic field, or light. However, the manipulation of the Kondo effect in nonartificial materials has not been thoroughly studied; in particular, the artificial creation of the Kondo effect remains unexplored. Per this subject study, however, a route for the optical creation of the Kondo effect in the nonartificial material p -type semiconductor CeZn3P3 is presented. The Kondo effect emerges under visible-light illumination of the material by a continuous-wave laser diode and is ultimately revealed by photoinduced electrical resistivity, which clearly exhibits a logarithmic temperature dependency. By contrast, a La-based compound (LaZn3P3 ) displays only normal metallic behavior under similar illumination. The photoinduced Kondo effect, which occurs at higher temperatures when compared with the Kondo effect in artificial systems, provides a potential range of operation for not only quantum information/computation devices but also for operation of magneto-optic devices, thereby expanding the range of device applications based on the Kondo effect.

  15. Safeguards-by-design: 3S integration

    integration of nuclear safeguards, safety, and security (3S), is a logical and important step in the evolution of the design process, as has been recognized by the IAEA and member states. Integrating SBD with tight links to safety as well takes advantage of the maturity of the nuclear safety experience, properly coordinates the safety requirements with the safeguards and security requirements, and minimizes the negative impact of retrofits during design and construction. (author)

  16. Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.

    Gunn, Adam P; Wong, Bruce X; Johanssen, Timothy; Griffith, James C; Masters, Colin L; Bush, Ashley I; Barnham, Kevin J; Duce, James A; Cherny, Robert A

    2016-03-18

    Pyroglutamate-modified amyloid-β (pE-Aβ) is a highly neurotoxic amyloid-β (Aβ) isoform and is enriched in the brains of individuals with Alzheimer disease compared with healthy aged controls. Pyroglutamate formation increases the rate of Aβ oligomerization and alters the interactions of Aβ with Cu(2+) and lipids; however, a link between these properties and the toxicity of pE-Aβ peptides has not been established. We report here that Aβ3pE-42 has an enhanced capacity to cause lipid peroxidation in primary cortical mouse neurons compared with the full-length isoform (Aβ(1-42)). In contrast, Aβ(1-42) caused a significant elevation in cytosolic reactive oxygen species, whereas Aβ3pE-42 did not. We also report that Aβ3pE-42 preferentially associates with neuronal membranes and triggers Ca(2+) influx that can be partially blocked by the N-methyl-d-aspartate receptor antagonist MK-801. Aβ3pE-42 further caused a loss of plasma membrane integrity and remained bound to neurons at significantly higher levels than Aβ(1-42) over extended incubations. Pyroglutamate formation was additionally found to increase the relative efficiency of Aβ-dityrosine oligomer formation mediated by copper-redox cycling. PMID:26697885

  17. Microstructure and Strength of Brazed Joints of Ti3Al Base Alloy with Cu-P Filler Metal

    Peng HE; Jicai FENG; Heng ZHOU

    2005-01-01

    Brazing of Ti3Al alloys with the filler metal Cu-P was carried out at 1173~1273 K for 60~1800 s. When products are brazed, the optimum brazing parameters are as follows: brazing temperature is 1215~1225 K; brazing time is 250~300 s. Four kinds of reaction products were observed during the brazing of Ti3Al alloys with the filler metal Cu-P, i.e., Ti3Al phase with a small quantity of Cu (Ti3Al(Cu)) formed close to the Ti3Al alloy; the TiCu intermetallic compounds layer and the Cu3P intermetallic compounds layer formed between Ti3Al(Cu) and the filler metal, and a Cu-base solid solution formed with the dispersed Cu3P in the middle of the joint. The interfacial structure of brazed Ti3Al alloys joints with the filler metal Cu-P is Ti3Al/Ti3Al(Cu)/TiCu/Cu3P/Cu solid solution (Cu3P)/Cu3P/TiCu/Ti3Al(Cu)/Ti3Al, and this structure will not change with brazing time once it forms. The thickness of TiCu+Cu3P intermetallic compounds increases with brazing time according to a parabolic law. The activation energy Q and the growth velocity K0 of reaction layer TiCu+Cu3P in the brazed joints of Ti3Al alloys with the filler metal Cu-P are 286 k J/mol and 0.0821 m2/s, respectively, and growth formula was y2=0.0821exp(-34421.59/T)t.Careful control of the growth for the reaction layer TiCu+Cu3P can influence the final joint strength. The formation of the intermetallic compounds TiCu+Cu3P results in embrittlement of the joint and poor joint properties. The Cu-P filler metal is not fit for obtaining a high-quality joint of Ti3Al brazed.

  18. First Detection of [C I] $^3$P$_1$-$^3$P$_0$ Emission from a Protoplanetary Disk

    Tsukagoshi, Takashi; Saito, Masao; Kitamura, Yoshimi; Shimajiri, Yoshito; Kawabe, Ryohei

    2015-01-01

    We performed single point [C I] $^3$P$_1$-$^3$P$_0$ and CO J=4-3 observations toward three T Tauri stars, DM Tau, LkCa 15, and TW Hya, using the Atacama Large Millimeter/submillimeter Array (ALMA) Band 8 qualification model receiver installed on the Atacama Submillimeter Telescope Experiment (ASTE). Two protostars in the Taurus L1551 region, L1551 IRS 5 and HL Tau, were also observed. We successfully detected [C I] emission from the protoplanetary disk around DM Tau as well as the protostellar targets. The spectral profile of the [C I] emission from the protoplanetary disk is marginally single-peaked, suggesting that atomic carbon (C) extends toward the outermost disk. The detected [C I] emission is optically thin and the column densities of C are estimated to be <~10$^{16}$ cm$^{-2}$ and ~10$^{17}$ cm$^{-2}$ for the T Tauri star targets and the protostars, respectively. We found a clear difference in the total mass ratio of C to dust, $M$(C)/$M$(dust), between the T Tauri stars and protostellar targets; t...

  19. Is Upsilon(3S) a pure S-wave?

    Chakravarty, S; Ko, P; Chakravarty, Sumantra; Kim, Sun Myong; Ko, Pyungwon

    1993-01-01

    Assuming the QCD multipole expansion is applicable to hadronic transitions of Upsilon(3S) into lower level bottomonia, we consider the possibility that Upsilon(3S) has a D-wave component. This assumption leads to a natural explanation of the pi-pi spectrum in Upsilon(3S) -> Upsilon(1S) pi-pi. Consequences of this assumption on other hadronic and radiative transitions of Upsilon(3S) are also discussed in the same context.

  20. Untersuchung und Charakterisierung des Phasengebietes M-Q-X (M = Ag, Cu; Q = Chalkogen; X = Halogen)

    Giller, Malte

    2015-01-01

    Diese Dissertation beschreibt die Synthese und Charakterisierung von neuen Verbindungen, im Phasengebiet Cu-Te-Br und Cu-Te-S, sowie der festen Lösung von Cu10Te4Cl3 und Ag10Te4Br3. Hierbei wurden drei neue Phasen, Cu4.8(1)Te3Br, Cu5.4(1)Te3Br und Cu6Te3S isoliert und als kupfergefüllte Varianten des Cr3Si-Strukturtyps charakterisiert.

  1. Rydberg series in the photoionization of the excited 1s2s3s 1,3Se states of atomic beryllium

    Photoionization cross sections for ionization to Be+(2s, 2p, 3s, 3p, and 3d) states from the excited 2s3s 1,3S states of atomic beryllium, which contain several autoionizing Rydberg series of resonances converging to the Be+(2p, 3s, 3p, and 3d) states, have been calculated by an enhanced noniterative eigenchannel R-matrix method. Lower members of the Rydberg series of resonances with n ≤ 10 are identified along with the calculated resonance positions Er, effective quantum numbers n*, and widths Γ. The present results are compared with those of previous calculation and very good agreement between them is noted. There is excellent agreement between length and velocity gauges in the present calculation. (author)

  2. The synthesis of the heterocubane cluster [{CpMn}4(μ3-P)4] as a tetrahedral shaped starting material for the formation of polymeric coordination compounds.

    Heinl, Sebastian; Kiefer, Konrad; Balázs, Gábor; Wickleder, Claudia; Scheer, Manfred

    2015-09-11

    Thermolysis of [CpMn(η(6)-cht)] with P4 in 1,3-diisopropylbenzene leads to the formation of the heterocubane [Cp4Mn4P4] () in high yields, as a rare example of 'naked' phosphorus containing complexes of manganese. Compound is characterized and studied by DFT calculations and reflection measurements. 1D coordination polymers [{(CpMn)4(μ3-P)4}(CuX)]n (2-Cl: X = Cl; 2-Br: X = Br) are obtained in the reaction with CuX. Furthermore, it is shown that all four P atoms in can be addressed for a coordination towards cymantrene resulting in [{(CpMn)4(μ3-P)4}{CpMn(CO)2}n] (: n = 1; : n = 2; : n = 3; : n = 4), and shows that is a tetra-topic building block in coordination chemistry. PMID:26225545

  3. Gibbs energy of formation of UPd3(s)

    Gibbs energy of formation of UPd3(s) has been determined by measuring the equilibrium CO(g) pressure over {UO2(s) + C(s) + UPd3(s) + UPd4(s)} and is given as (ΔfG0m(UPd3,s,T) kJ mol-1±4.1=-526.9+0.1259 T (K), (1175≤T (K)≤1333) Using the required literature data, ΔfH0m(UPd3, s, 298.15 K) has been calculated as -(502.3 ± 5.1) kJ mol-1

  4. Variation of 3s photoionization resonance structures in a serial atomic number species Ar, K, and Ca

    Subvalence 3s-shell photoionization resonances of Ca were measured with monochromatized synchrotron radiation and photoion time-of-flight spectroscopy method. Charge resolved photoion yield spectra were obtained. Broad peak structures were found in the Ca+ spectrum and shallow window structures were found in the Ca2+ spectrum. We performed MCDF calculations to assign the resonance structures. The 3s-shell photoionization of Ar and K were also measured for comparison. A systematic increase was observed in Fano-Beutler parameter and in the resonance width along with the increase of atomic number from Z=18(Ar) to 20(Ca). We discuss also the spectral structures that could be of the 3p double-shake-up satellites, which are observed in the 3s photoionization region. (author)

  5. Promising bifunctional chelators for copper 64-PET imaging: practical (64)Cu radiolabeling and high in vitro and in vivo complex stability.

    Wu, Ningjie; Kang, Chi Soo; Sin, Inseok; Ren, Siyuan; Liu, Dijie; Ruthengael, Varyanna C; Lewis, Michael R; Chong, Hyun-Soon

    2016-04-01

    Positron emission tomography (PET) using copper-64 is a sensitive and non-invasive imaging technique for diagnosis and staging of cancer. A bifunctional chelator that can present rapid radiolabeling kinetics and high complex stability with (64)Cu is a critical component for targeted PET imaging. Bifunctional chelates 3p-C-NE3TA, 3p-C-NOTA, and 3p-C-DE4TA were evaluated for complexation kinetics and stability with (64)Cu in vitro and in vivo. Hexadentate 3p-C-NOTA and heptadentate 3p-C-NE3TA possess a smaller TACN-based macrocyclic backbone, while nonadentate 3p-C-DE4TA is constructed on a larger CYCLEN-based ring. The frequently explored chelates of (64)Cu, octadentate C-DOTA and hexadentate C-NOTA were also comparatively evaluated. Radiolabeling kinetics of bifunctional chelators with (64)Cu was assessed under mild conditions. All bifunctional chelates instantly bound to (64)Cu in excellent radiolabeling efficiency at room temperature. C-DOTA was less efficient in binding (64)Cu than all other chelates. All (64)Cu-radiolabeled bifunctional chelates remained stable in human serum without any loss of (64)Cu for 2 days. When challenged by an excess amount of EDTA, (64)Cu complexes of C-NOTA, 3p-C-NE3TA and 3p-C-NOTA were shown to be more stable than (64)Cu-C-DOTA and (64)Cu-3p-C-DE4TA. (64)Cu complexes of the new chelates 3p-C-NE3TA and 3p-C-NOTA displayed comparable in vitro and in vivo complex stability to (64)Cu-C-NOTA. In vivo biodistribution result indicates that the (64)Cu-radiolabeled complexes of 3p-C-NOTA and 3p-C-NE3TA possess excellent in vivo complex stability, while (64)Cu-3p-C-DE4TA was dissociated as evidenced by high renal and liver retention in mice. The results of in vitro and in vivo studies suggest that the bifunctional chelates 3p-C-NE3TA and 3p-C-NOTA offer excellent chelation chemistry with (64)Cu for potential PET imaging applications. PMID:26666778

  6. Linkage of autosomal dominant dystrophic epidermolysis bullosa in three British families to the marker D3S2 close to the COL7A1 locus.

    al-Imara, L; Richards, A J; Eady, R A; Leigh, I M; Farrall, M; Pope, F M

    1992-01-01

    Linkage of the anonymous marker D3S2 at 3p21 has been shown in three British families with dominant dystrophic epidermolysis bullosa with a combined lod score of 6.75 at theta = 0. This locus is close to the collagen type VII locus implying that abnormalities of this gene cause dominant dystrophic epidermolysis bullosa.

  7. Nascent 60S ribosomal subunits enter the free pool bound by Nmd3p.

    Ho, J. H.; Kallstrom, G; Johnson, A. W.

    2000-01-01

    Nmd3p from yeast is required for the export of the large (60S) ribosomal subunit from the nucleus (Ho et al., 2000). Here, we show that Nmd3p forms a stable complex with free 60S subunits. Using an epitope-tagged Nmd3p, we show that free 60S subunits can be coimmunoprecipitated with Nmd3p. The interaction was specific for 60S subunits; 40S subunits were not coimmunoprecipitated. Using this coprecipitation technique and pulse-chase labeling of ribosomal subunit proteins we showed that Nmd3p bo...

  8. Computational studies of modified [Fe3S4] clusters: Why iron is optimal

    Kepp, Kasper Planeta

    2008-01-01

    This work reports density functional computations of metal-substituted models of biological [Fe3S4] clusters in oxidation states [MFe2S4]+/0/−1 (M = Mn, Fe, Co, Ni, Cu, Zn, and Mo). Geometry optimization with a dielectric screening model is shown to provide a substantial improvement in structure......, compared to earlier used standard procedures. The error for average Fe–S bonds decreased from 0.038 Å to 0.016 Å with this procedure. Four density functionals were compared, B3LYP, BP86, TPSS, and TPSSh. B3LYP and to a lesser extent TPSSh energies were inconsistent with experiment for the oxidized [Fe3S4......]+ cluster. BP86 (and to a slightly lesser extent TPSS) was within expected theoretical and experimental uncertainties for all oxidation states, the only qualitative error being 5 kJ/mol in favor of the MS = 3/2 configuration for the [Fe3S4]+ cluster, so BP86 was used for quantitative results. Computed...

  9. Mn 3s exchange splitting in mixed-valence manganites.

    Galakhov, V. R.; Demeter, M.; Bartkowski, S.; Neumann, M.; Ovechkina, N. A.; Kurmaev, E. Z.; Lobachevskaya, N. I.; Mukovskii, Ya. M.; Mitchell, J.; Ederer, D. L.; Russian Academy of Sciences; Univ. of Osnabruck; Moscow State Steel and Alloys Inst.; Tulane Univ.

    2002-03-15

    We present Mn 3s x-ray photoelectron spectra of manganese oxides with the Mn formal valency from 2+ to 4+. We found that the Sr{sup 2+} doping or cation deficiency in manganites do not change the Mn 3s splitting in manganites with the Mn formal valency from 3.0+ to 3.3+. We suggest that doping holes are localized in O 2p states.

  10. Crystal structure of bis{S-hexyl 3-[4-(dimethylaminobenzylidene]dithiocarbazato-κ2N3,S}copper(II

    E. Zangrando

    2015-06-01

    Full Text Available In the title complex, [Cu(C16H24N3S22], the CuII atom is coordinated by two azomethine N and two thiolate S atoms of the chelating Schiff base ligands, resulting in a distorted square-planar coordination environment. The S—Cu—N chelating angle is of 84.41 (5°. The CuII atom is located on a crystallographic inversion centre, leading to a trans configuration of the N,S-chelating ligands.

  11. Accurate long-range coefficients for two excited like isotope He atoms: He(2 1P)-He(2 1P), He(2 1P)-He(2 3P), and He(2 3P)-He(2 3P)

    A general formalism is used to express the long-range potential energies in inverse powers of the separation distance between two like atomic or molecular systems with P symmetries. The long-range molecular interaction coefficients are calculated for the molecular symmetries Δ, Π, and Σ, arising from the following interactions: He(2 1P)-He(2 1P), He(2 1P)-He(2 3P), and He(2 3P)-He(2 3P). The electric quadrupole-quadrupole term C5, the van der Waals (dispersion) term C6, and higher-order terms C8 and C10 are calculated ab initio using accurate variational wave functions in Hylleraas coordinates with finite nuclear mass effects. A comparison is made with previously published results where available

  12. Thermodynamic properties of SrRuO3(s)

    The enthalpy increment measurements and the standard molar Gibb's energy of formation of SrRuO3(s) were measured using a high-temperature Calvet micro-calorimeter and a galvanic cell, respectively. The enthalpy increments can be represented by the polynomial expression: H0(T)-H0(298.15 K) (J mol-1)=-43517.2+120.8T (K)+0.898x10-2T2 (K)+19.97x105/T (K) [SrRuO3(s), 310.4≤T (K)≤798.8]. The heat capacity C0p,m(T), the first differential of H0(T)-H0(298.15 K) with respect to temperature is given by: C0p,m (SrRuO3, s, T) (J mol-1 K-1)=120.8+1.796x10-2T (K)-19.97x105/T2 (K). The standard Gibbs energy of formation of SrRuO3(s) has been determined by a galvanic cell using CaF2(s) as the solid electrolyte. The fluoride cell is represented by: (-)Pt/O2(g), {CaO(s)+CaF2(s)}//CaF2//{SrF2(s)+RuO2(s)+SrRuO3(s)}, O2(g)/Pt(+). The electromotive force (emf) of the above cell was measured as a function of temperature in the range from 894.4 to 1098 K. The standard Gibb's energy of formation of SrRuO3(s) from elements in their standard state obtained by the fluoride cell can be given by: ΔfG0[SrRuO3(s)]/kJ mol-1(±2)=-941.0+0.2586·(T/K) (894.4av=996.2 K. The heat capacity of SrRuO3(s) determined by Calvet calorimeter and the data obtained from fluoride cell were used to calculate the standard enthalpy and entropy of formation of the compound at 298.15 K. The second law method gives ΔfH0[SrRuO3(s), 298.15 K] and ΔfS0[SrRuO3(s), 298.15 K] of the compound from elements in their standard state to be -955.0 kJ mol-1 and 111.04 J K-1 mol-1, respectively

  13. Synthesis of (3S,4R)-bengamide E

    Qi Jun Liu; Hong Li; Shao Peng Chen; Guo Chun Zhou

    2011-01-01

    (3S,4R)-Bengamide E (2) was synthesized starting from D-glucono-δ-lactone (3) and the key deoxygenation step from 13 to 15 was achieved by the application of NaBH3CN and ZnI2. Compared with natural bengamide E (1), the synthetic compound (3S,4R)-bengamide E (2) was inactive against the cell growth of HUVEC and cancer cells. These data represent the significance of the stereochemistry at C-3 and C-4 of bengamides for structural recognition and binding with the target(s).

  14. The effect of Sm, Eu and Yb on the thermoelectric properties of Th/sub 3/P/sub 4/ - type lanthanum sulfide

    The Th/sub 3/P/sub 4/-type lanthanum sulfides are n-type semiconductors and a continuous series of solid solutions is found between the compositions of La/sub 3/S/sub 4/ and La/sub 2/S/sub 3/. These materials are attractive for use in high temperature thermoelectric applications because of their high melting points, low thermal conductivities and their inherent ability to vary the electron concentration from a maximum of 6.02 X 10/sup 21/ cm/sup -3/ for La/sub 3/S/sub 4/ to zero for La/sub 2/S/sub 3/ (i.e., self-doping). In this study, La/sub 3/S/sub 4/ compounds in which trivalent La has been partially substituted by divalent Sm, Eu or Yb (La/sub 3-x/M/sub x/S/sub 4/, x = 0.1 to 0.9) have been prepared by the pressure assisted reaction sintering method and were found to have the Th/sub 3/P/sub 4/ structure. The thermoelectric properties (Seebeck coefficient and electrical resistivity) were measured as a function of temperature and the optimum composition was found for x between 0.2 and 0.3 in which the electrical power factor was a maximum at 10000C

  15. The direct measurement of the 3 3P0-3 3P1 fine-structure interval and the gJ-factor of atomic silicon by laser magnetic resonance

    Evenson, K. M.; Beltran-Lopez, V.; Ley-Koo, E.; Inguscio, M.

    1984-01-01

    The J - 1 fine structure interval and the g-factor of the 3P1 state have been determined with high precision in the present laser magnetic resonance measurements of the ground 3p2 3P multiplet of atomic Si. Delta-E(3P1-3P0) = 2,311,755.6(7) MHz, and gJ(3P1) = 1.500830(70). Single-configuration calculations of gJ for 3P1 and 3P2 yield a value for the latter which, at 1.501095, is noted to differ by an unexpectedly large margin from the experimental value.

  16. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    Carette, Thomas; Nemouchi, Messaoud; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are op...

  17. Medium Effects in Cooling of Neutron Stars and $3P_2$ Neutron Gap

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``nuclear medium cooling'' scenario is in favor of a suppressed value of the $3P_2$ neutron gap.

  18. On the magnetocrystalline anisotropy of greigite (Fe3S 4)

    Winklhofer, M.; Chang, L.; Eder, S.H.K.

    2014-01-01

    The ferrimagnetic mineral greigite (cubic Fe3S4) is well known as an intracellular biomineralization product in magnetic bacteria and as a widely occurring authigenic mineral in anoxic sediments. Due to the lack of suitable single-crystal specimens, the magnetic anisotropy parameters of greigite hav

  19. A case of 3p deletion syndrome associated with cerebellar hemangioblastoma.

    Suzuki-Muromoto, Sato; Hino-Fukuyo, Naomi; Haginoya, Kazuhiro; Kikuchi, Atsuo; Sato, Hiroki; Sato, Yuko; Nakayama, Tojo; Kubota, Yuki; Kakisaka, Yosuke; Uematsu, Mitsugu; Kumabe, Toshihiro; Md, Shigeo Kure

    2016-02-01

    We described clinical course of a 24-year-old woman with 3p deletion syndrome associated with cerebellar hemangioblastoma at the age of 16 years old. She presented dysmorphic facial features, growth retardation and severe psychomotor retardation associated with 3p deletion syndrome. We identified de novo 3p deletion encompassing p25 by using array-based comparative genomic hybridization, where causative gene of von Hippel-Lindau (VHL) disease located. Surgical therapy for cerebellar hemangioblastoma was performed, and histological examination was consistent in cerebellar hemangioblastoma. She showed no other tumors associated VHL disease till 24 years old. This is the first case report of a patient with 3p deletion syndrome whose cerebellar hemangioblastoma may be associated with VHL disease. Repeat imaging studies were recommended for the patients with 3p deletion syndrome. PMID:26365017

  20. Synthetic smythite and monoclinic Fe3S4

    Fleet, Michael E.

    1982-11-01

    Smythite and monoclinic Fe3S4 have been identified by X-ray diffraction procedures in quenched ironsulfide compositions. Both phases appear to be metastable under the conditions of the experiments and their development is structurally induced. Smythite occurs as a coherent twinned intergrowth with hexagonal 3C pyrrhotite. Individual single crystals contain about 50% smythite. Reciprocal lattice rows with h-k ≠ 3n show continuous diffraction streaks. The available data suggest that smythite forms via a “polytypic” displacive transformation, by the introduction of stacking faults in the hexagonal close-packed layers of S atoms in high-temperature 1C pyrrhotite. This is analogous to the transformation of 2H wurtzite to intermediate ordered and disordered ZnS layer sequences. The ideal formula of smythite appears to be Fe13S16. Monoclinic Fe3S4 ( a=5.93, b=3.42, c=10.64 Å, β=91.9°) is present in amounts up to 25% of total sulfides. It has a derivative NiAs-type structure, and is isomorphous with monoclinic Cr3S4 and Fe3Se4. It occurs as small lenticular lamellae within grains of 3C pyrrhotite, and apparently corresponds to the unidentified lamellar phase of Arnold (1962). The lamellae have a rhombohedral morphology, with a habit plane close to {1011}. In single crystal grains of pyrrhotite, monoclinic Fe3S4 in twinned in a manner consistent with transformation from high-temperature 1C pyrrhotite. Although Fe3S4 lamellae have the general appearance of plate martensite, they do not represent a diffusionless transformation.

  1. Towards a Mg lattice clock: Observation of the $^1S_{0}-$$^3P_{0}$ transition and determination of the magic wavelength

    Kulosa, A P; Zipfel, K H; Rühmann, S; Sauer, S; Jha, N; Gibble, K; Ertmer, W; Rasel, E M; Safronova, M S; Safronova, U I; Porsev, S G

    2015-01-01

    We optically excite the electronic state $3s3p~^3P_{0}$ in $^{24}$Mg atoms, laser-cooled and trapped in a magic-wavelength lattice. An applied magnetic field enhances the coupling of the light to the otherwise strictly forbidden transition. We determine the magic wavelength, the quadratic magnetic Zeeman shift and the transition frequency to be 468.463(207)$\\,$nm, -206.6(2.0)$\\,$MHz/T$^2$ and 655 058 646 691(101)$\\,$kHz, respectively. These are compared with theoretical predictions and results from complementary experiments. We also developed a high-precision relativistic structure model for magnesium, give an improved theoretical value for the blackbody radiation shift and discuss a clock based on bosonic magnesium.

  2. Ge 3P 6Si 2O 25: A cage structure closely related to the intersecting tunnel structure KMo 3P 6Si 2O 25

    Leclaire, A.; Raveau, B.

    1988-08-01

    A germanosilicophosphate Ge 3P 6Si 2O 25 has been isolated. Its structure was solved from a single-crystal study in the space group P overline31c . Its cell parameters are a = b = 7.994(1) Å, c = 16.513(2) Å, Z = 2. The refinement by full-matrix least-squares calculations leads to R = 0.043 with 686 independent reflections. The structure of this oxide is built up from corner-sharing PO 4 and SiO 4 tetrahedra and GeO 6 octahedra. One observes a feature common to several silicophosphates: the presence of the structural unit P 6Si 2O 25 built up from a disilicate group sharing its corners with six PO 4 tetrahedra. The structural relationships between this oxide and the silicophosphates AMo 3P 6Si 2O 25 and Si 3P 6Si 2O 25 (or Ge 3P 6 Ge 2O 25) are described.

  3. Preparation, spectroscopic investigation and antiproliferative capacity of new metal complexes of (3E)-2-(hydroxyimino)-N-P-Tolyl-3-(P-tolylimino) butanamide

    El-Tabl, Abdou Saad; Abd El-wahed, Moshira Mohamed; Abd El-Razek, Samar Ebrahim

    2013-03-01

    Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Sr(II), Hg(II), Tl(I), UO2(II) and ZrO(II) complexes of (3E)-2-(hydroxyimino)-N-P-Tolyl-3-(P-tolylimino) butanamide have been prepared and characterized by elemental analyses, IR, UV-Vis spectra, magnetic moments, conductances, 1H NMR and mass spectra (ligand and its Zn(II) complex), thermal analyses (DTA and TGA) and ESR measurements. The IR data show that, the ligand behaves as monobasic bidentate or neutral bidentate. Molar conductances in DMF indicate that, the complexes are non-electrolytes. ESR spectra of solid Cu(II) complexes at room temperature show axial type (dx2-y2) with covalent bond character in an octahedral environment. Complexes showed inhibitory activity against hepatocellular carcinoma (HepG-2 cell line).

  4. Electronic and Rovibrational Quantum Chemical Analysis of C$_3$P$^-$: The Next Interstellar Anion?

    Fortenberry, Ryan C

    2015-01-01

    C$_3$P$^-$ is analogous to the known interstellar anion C$_3$N$^-$ with phosphorus replacing the nitrogen in a simple step down the periodic table. In this work, it is shown that C$_3$P$^-$ is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C$_3$P$^-$ has a valence excited state that may lead to further stabilization of this molecule, and C$_3$P$^-$ has a larger dipole moment than neutral C$_3$P ($\\sim 6$ D vs. $\\sim 4$ D). As such, C$_3$P$^-$ is probably a more detectable astromolecule than even its corresponding neutral radical. Highly-accurate quantum chemical quartic force fields are also applied to C$_3$P$^-$ and its singly $^{13}$C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  5. Electronic and rovibrational quantum chemical analysis of C3P-: the next interstellar anion?

    Fortenberry, Ryan C.; Lukemire, Joseph A.

    2015-11-01

    C3P- is analogous to the known interstellar anion C3N- with phosphorus replacing nitrogen in a simple step down the periodic table. In this work, it is shown that C3P- is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C3P- has a valence excited state that may lead to further stabilization of this molecule, and C3P- has a larger dipole moment than neutral C3P (˜6 D versus ˜4 D). As such, C3P- is probably a more detectable astromolecule than even its corresponding neutral radical. Highly accurate quantum chemical quartic force fields are also applied to C3P- and its singly 13C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  6. Fundamental magnetic properties of Greigite (Fe3S4)

    Chang, Liao

    2009-01-01

    Over the last twenty years, greigite (Fe3S4), an authigenic magnetic iron sulphide mineral, has been increasingly identified in sulphate-reducing marine and lacustrine sedimentary systems. Its presence can significantly affect palaeomagnetic and environmental magnetic records. Understanding the recording characteristics of any magnetic mineral requires that its fundamental magnetic properties are known. However, unlike magnetite (Fe3O4) and other common terrestrial magnetic minerals, the fund...

  7. Inclusive χ(2P) production in Υ(3S) decay

    Using the CsI calorimeter of the CLEO II detector, the spin triplet χb(2P) states are observed in Υ(3S) radiative decays with much higher statistics than seen in previous experiments. The observed mass splittings are not described well by theoretical models, while the relative branching ratios agree with predictions that include relativistic corrections to the radiative transition rates

  8. Sizeable beta-strength in {sup 31}Ar (β3p) decay

    Koldste, G.T. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Blank, B. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Borge, M.J.G.; Briz, J.A.; Carmona-Gallardo, M. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Fraile, L.M. [Grupo de Física Nuclear, Universidad Complutense, CEI Moncloa, E-28040 Madrid (Spain); Fynbo, H.O.U. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Giovinazzo, J. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Johansen, J.G. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Jokinen, A. [Department of Physics, University of Jyväskylä, FIN-40351 Jyväskylä (Finland); Jonson, B. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Kurturkian-Nieto, T. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Nilsson, T. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Perea, A.; Pesudo, V. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); and others

    2014-10-07

    We present for the first time precise spectroscopic information on the recently discovered decay mode β-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow–Teller strength distribution from the decay of {sup 31}Ar revealing that as much as 30% of the strength resides in the β3p-decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in {sup 31}Cl is provided.

  9. Progress on the Multiphysics Capabilities of the Parallel Electromagnetic ACE3P Simulation Suite

    Kononenko, Oleksiy [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-03-26

    ACE3P is a 3D parallel simulation suite that is being developed at SLAC National Accelerator Laboratory. Effectively utilizing supercomputer resources, ACE3P has become a key tool for the coupled electromagnetic, thermal and mechanical research and design of particle accelerators. Based on the existing finite-element infrastructure, a massively parallel eigensolver is developed for modal analysis of mechanical structures. It complements a set of the multiphysics tools in ACE3P and, in particular, can be used for the comprehensive study of microphonics in accelerating cavities ensuring the operational reliability of a particle accelerator.

  10. Sizeable beta-strength in 31Ar (beta 3p) decay

    T. Koldste, G.; Blank, B.; J. G. Borge, M.;

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as...... much as 30% of the strength resides in the beta-3p decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in 31Cl is provided....

  11. Safeguards-by-Design: An Element of 3S Integration

    In 2008, the '20/20 Vision for the Future' background report by the IAEA Director General identified the possibility of integrating certain activities related to safeguards, safety, and security. Later in the year, the independent Commission report prepared at the request of the IAEA Director General noted that the Agency's's roles in nuclear safeguards, safety, and security (3S) complement and can mutually reinforce each other. Safeguards-by-design (SBD) is a practical measure that strengthens 3S integration, especially for the stage of nuclear facility design and construction, but also with ramifications for other stages of the facility life-cycle. This paper describes the SBD concept, with examples for diverse regulatory environments, being developed in the U.S under the U.S. Department of Energy (DOE) Next Generation Safeguards Initiative and the Advanced Fuel Cycle Initiative. This is compared with related international SBD work performed in the recent IAEA workshop on 'Facility Design and Plant Operation Features that Facilitate the Implementation of IAEA Safeguards'. Potential future directions for further development of SBD and its integration within 3S are identified.

  12. Investigation of the H-Cu and Cu-Cu bonds in hydrogenated Cu

    Shuttleworth, I. G.

    2013-01-01

    The pure and hydrogenated copper system CuHn (n=0, 0.25, 0.50, 0.75 and 1) has been investigated using LCAO-DFT. The average H-Cu (Cu-Cu) bonding interaction increases (decreases) with n whilst concurrent orbital-resolved studies of the H-Cu interactions showed that the (non-)directional H-Cu bonds become more (less) bonding. This preference for directional bonds is reflected in the Cu-Cu interactions. CuH0.25 is shown to have an unusually localized electronic structure compared to the more hydrogenated systems, and the origins of this structure are discussed.

  13. Multiscale Hy3S: Hybrid stochastic simulation for supercomputers

    Kaznessis Yiannis N

    2006-02-01

    Full Text Available Abstract Background Stochastic simulation has become a useful tool to both study natural biological systems and design new synthetic ones. By capturing the intrinsic molecular fluctuations of "small" systems, these simulations produce a more accurate picture of single cell dynamics, including interesting phenomena missed by deterministic methods, such as noise-induced oscillations and transitions between stable states. However, the computational cost of the original stochastic simulation algorithm can be high, motivating the use of hybrid stochastic methods. Hybrid stochastic methods partition the system into multiple subsets and describe each subset as a different representation, such as a jump Markov, Poisson, continuous Markov, or deterministic process. By applying valid approximations and self-consistently merging disparate descriptions, a method can be considerably faster, while retaining accuracy. In this paper, we describe Hy3S, a collection of multiscale simulation programs. Results Building on our previous work on developing novel hybrid stochastic algorithms, we have created the Hy3S software package to enable scientists and engineers to both study and design extremely large well-mixed biological systems with many thousands of reactions and chemical species. We have added adaptive stochastic numerical integrators to permit the robust simulation of dynamically stiff biological systems. In addition, Hy3S has many useful features, including embarrassingly parallelized simulations with MPI; special discrete events, such as transcriptional and translation elongation and cell division; mid-simulation perturbations in both the number of molecules of species and reaction kinetic parameters; combinatorial variation of both initial conditions and kinetic parameters to enable sensitivity analysis; use of NetCDF optimized binary format to quickly read and write large datasets; and a simple graphical user interface, written in Matlab, to help users

  14. MPI spectroscopy in the region of the 3p Rydberg state of some cycloketones

    Kosmidis, C.; Boulakis, G.; Bolovinos, A.; Tsekeris, P.; Brint, P.

    1992-03-01

    The two-photon resonance three photon ionization spectra of cyclopentanone, cyclohexanone and cycloheptanone in the region of the 3p Rydberg state have been recorded, analysed and compared with the one-photon absorption spectra. A new 3p origin is identified for cyclopentanone. The absence from the MPI spectra of a sharp spectral feature that is observed in the absorption spectra is discussed. Photochemical generation of acetaldehyde is observed at high laser intensities and possible mechanisms for this are considered.

  15. miR-1207-3p Is a Novel Prognostic Biomarker of Prostate Cancer.

    Das, Dibash K; Osborne, Joseph R; Lin, Hui-Yi; Park, Jong Y; Ogunwobi, Olorunseun O

    2016-06-01

    MicroRNAs (miRNAs) have been found to be dysregulated in prostate cancer (PCa). In this study, we investigated if miR-1207-3p is capable of distinguishing between indolent and aggressive PCa and if it contributes to explaining the disproportionate aggressiveness of PCa in men of African ancestry (moAA). A total of 404 patients with primary adenocarcinoma of the prostate were recruited between 1988 and 2003 at the Moffitt Cancer Center, Tampa, FL, USA. Patient clinicopathological features and demographic characteristics such as race were identified. RNA samples from 404 postprostatectomy prostate tumor tissue samples were analyzed by real-time quantitative reverse transcription polymerase chain reaction for the mRNA expression of miR-1207-3p. miR-1207-3p expression in PCa that resulted in overall death or PCa-specific death is significantly higher than in PCa cases that did not. The same positive correlation holds true for other clinical characteristics such as biochemical recurrence, Gleason score, clinical stage, and prostate-specific antigen level. Furthermore, miR-1207-3p expression was significantly less in moAA in comparison to Caucasian men. We also evaluated whether miR-1207-3p is associated with clinical outcomes adjusted for age at diagnosis and tumor stage in the modeling. Using competing risk regression, the PCa patients with a high miR-1207-3p expression (≥6 vs 3) had a high risk to develop PCa recurrence (hazard rate = 2.5, P < .001) adjusting for age at diagnosis and tumor stage. In conclusion, miR-1207-3p is a promising novel prognostic biomarker for PCa. Furthermore, miR-1207-3p may also be important in explaining the disproportionate aggressiveness of PCa in moAA. PMID:27267842

  16. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    Aibing WU

    2015-07-01

    Full Text Available Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in NSCLC tissues and lung adenocarcinoma cell lines was detected by quantitative reverse transcription polymerase chain reaction. The roles of miR-373-3p in regulating lung adenocarcinoma cell invasion and metastatic properties were analyzed with miR-373-3p mimic/inhibitor-transfected cells via Transwell chamber assay. Matrix metalloproteinase MMP-9 and MMP-14 protein levels were detected by Western blot in lung cancer cells after transfection. Results MiR-373-3p was upregulated in 51 NSCLC tissues and 5 NSCLC cell lines. Gain-of-function and loss-of-function studies showed that overexpression of miR-373-3p promoted H1299 cell migration and invasion, which resulted in upregulation of MMP-9 and MMP-14. By contrast, miR-373-3p knockdown inhibited these processes in A549 cells and downregulated the expression of MMP-9 and MMP-14. Conclusion Our results demonstrated that miR-373-3p participated in the invasion and metastasis of lung adenocarcinoma cells, partly by upregulation of MMP-9 and MMP-14.

  17. Determination of diffusion, reflection and deexcitation coefficients of metastable excited Ne(3P2) atom

    Suzuki, S.; Itoh, H.

    2016-05-01

    The diffusion coefficient of the metastable excited Ne(3P2) atom in neon, the reflection coefficient of Ne(3P2) at the surface of an electrode and the rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) were determined from the gas pressure dependence of the effective lifetime of Ne(3P2). The effective lifetime of Ne(3P2) was measured from the transient current after turning off the Ultraviolet (UV) light in a Townsend discharge. The observed transient current waveform was analysed by solving the diffusion equation for the metastable excited Ne(3P2) atom using the third kind of boundary condition. The rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) and the reflection coefficient were determined by a nonspectroscopic method for the first time in neon to the best of our knowledge and were (3.2  ±  0.4)  ×  10‑16 cm3 s‑1 and 0.10  ±  0.04, respectively. The obtained diffusion coefficient at 1 Torr was 177  ±  17 cm2 s‑1, which is consistent with the value reported by Dixon and Grant. Moreover, the present results are compared with the results of Phelps and were found to be in good agreement. We also discuss the deexcitation rate of Ne(3P2) at pressures of up to 60 Torr in comparison with previously reported values.

  18. Ab-initio calculation of the 2s21S0-2s3p 3P1 intercombination transition in beryllium-like ions

    Transition probabilities of the 2s21S0-2s3p 1,3P1 intercombination and resonance lines have been calculated for 14 beryllium-like ions in the atomic range 7 ≤ Z ≤ 36. We used multiconfiguration Dirac-Fock wave functions to explore the effects of configuration interaction, of electron rearrangement as well as of relativity in a consistent scheme along the isoelectronic sequence. To show the number of configurations needed in a proper expansion of the wave functions we systematically enlarged the basis from small to large-scale. For the low-Z elements, virtual excitations of the 2s and 3p electrons up to the 5l subshells contribute significantly to the intercombination probability even though the transition energies remain almost unaffected by excitations beyond the 3l shells. The incomplete orthogonality of the orbital functions due to the rearrangement of the electron density clearly shifts the intercombination rates and appears to be independent of the configuration expansion. This effect decreases, as expected, at higher nuclear charges. (orig.)

  19. miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma.

    Williams, Marissa; Kirschner, Michaela B; Cheng, Yuen Yee; Hanh, Jacky; Weiss, Jocelyn; Mugridge, Nancy; Wright, Casey M; Linton, Anthony; Kao, Steven C; Edelman, J James B; Vallely, Michael P; McCaughan, Brian C; Cooper, Wendy; Klebe, Sonja; Lin, Ruby C Y; Brahmbhatt, Himanshu; MacDiarmid, Jennifer; van Zandwijk, Nico; Reid, Glen

    2015-09-15

    Malignant pleural mesothelioma (MPM) is an asbestos-induced cancer with poor prognosis that displays characteristic alterations in microRNA expression. Recently it was reported that the expression of a subset of microRNAs can distinguish between MPM and adenocarcinoma of the lung. However, the functional importance of these changes has yet to be investigated. We compared expression of miR-192, miR-193a-3p and the miR-200 family in normal pleura and MPM tumor specimens and found a statistically significant reduction in the levels of miR-193a-3p (3.1-fold) and miR-192 (2.8-fold) in MPM. Transfection of MPM cells with a miR-193a-3p mimic resulted in inhibition of growth and an induction of apoptosis and necrosis in vitro. The growth inhibitory effects of miR-193a-3p were associated with a decrease in MCL1 expression and were recapitulated by RNAi-mediated MCL1 silencing. Targeted delivery of miR-193a-3p mimic using EDV minicells inhibited MPM xenograft tumour growth, and was associated with increased apoptosis. In conclusion, miR-193a-3p appears to have importance in the biology of MPM and may represent a target for therapeutic intervention. PMID:26125439

  20. Protective role of miR-23b-3p in kainic acid-induced seizure.

    Zhan, Lianbo; Yao, Yi; Fu, Huajun; Li, Zhenghui; Wang, Fengpeng; Zhang, Xiaobin; He, Wencan; Zheng, Weihong; Zhang, Yunwu; Zheng, Honghua

    2016-07-01

    Dysregulation of microRNAs has been proposed to contribute toward epilepsy. The miRNA miR-23b-3p has been found to protect against neuronal apoptosis and the production of reactive oxygen species. In this study, we assessed the potential role of miR-23b-3p in the kainic acid (KA)-induced seizure model. We found that miR-23b-3p levels were significantly decreased in the brain cortex of mice and in cultured mouse primary neurons treated with KA. Importantly, supplement of miR-23b-3p agomir by an intacerebroventricular injection alleviated seizure behaviors and abnormal cortical electroencephalogram recordings in KA-treated mice. Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure. PMID:27232518

  1. Bonding and electronic properties of the Cu2ZnSnS4 /WZ–ZnO interface from first-principles calculations

    Cheng, Yu-Wen; Tang, Fu-Ling; Xue, Hong-Tao; Liu, Hong-Xia; Gao, Bo; Feng, Yu-Dong

    2016-07-01

    We theoretically explored the interface structure, binding energy, band offsets and electronic properties of the CZTS (1 0 2)/WZ–ZnO (1 1 0) interface from first-principles calculations. The interface has a small lattice mismatch of less than 3.2%. The interface binding energy is about  ‑0.21 J m‑2. The values of band offset indicate that such an interface belongs to the type-I heterojunction. New electronic density of states, the so called interface states, appear near the Fermi level. These states are attributed to Cu 3d, Sn 5s, S 3s and 3p orbitals on the first CZTS layer, Zn 4s and 3d, O 2s and 2p orbitals on the first WZ–ZnO layer. The orbital hybridizations and charge transfers on both sides strengthen the interfacial adhesion.

  2. Increased miR-132-3p expression is associated with chronic neuropathic pain.

    Leinders, M; Üçeyler, N; Pritchard, R A; Sommer, C; Sorkin, L S

    2016-09-01

    Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance. We set out to analyze the role of miR-132-3p, first in patients with peripheral neuropathies and second in an animal model of neuropathic pain. We initially determined miR-132-3p expression by measuring its levels in white blood cells (WBC) of 30 patients and 30 healthy controls and next in sural nerve biopsies of 81 patients with painful or painless inflammatory or non-inflammatory neuropathies based on clinical diagnosis. We found a 2.6 fold increase in miR-132-3p expression in WBC of neuropathy patients compared to healthy controls (panimal model of neuropathic pain, the spared nerve injury model (SNI). For this purpose miR-132-3p expression levels were measured in dorsal root ganglia and spinal cord of rats. Subsequently, miR-132-3p expression was pharmacologically modulated with miRNA antagonists or mimetics, and evoked pain and pain aversion were assessed. Spinal miR-132-3p levels were highest 10days after SNI, a time when persistent allodynia was established (pbehavior in the place escape avoidance paradigm (pbehavior in naïve rats (p<0.001). Taken together these results indicate a pro-nociceptive effect of miR-132-3p in chronic neuropathic pain. PMID:27349406

  3. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.

    Prashant K Mishra

    2011-09-01

    Full Text Available The kinetochore (centromeric DNA and associated proteins is a key determinant for high fidelity chromosome transmission. Evolutionarily conserved Scm3p is an essential component of centromeric chromatin and is required for assembly and function of kinetochores in humans, fission yeast, and budding yeast. Overexpression of HJURP, the mammalian homolog of budding yeast Scm3p, has been observed in lung and breast cancers and is associated with poor prognosis; however, the physiological relevance of these observations is not well understood. We overexpressed SCM3 and HJURP in Saccharomyces cerevisiae and HJURP in human cells and defined domains within Scm3p that mediate its chromosome loss phenotype. Our results showed that the overexpression of SCM3 (GALSCM3 or HJURP (GALHJURP caused chromosome loss in a wild-type yeast strain, and overexpression of HJURP led to mitotic defects in human cells. GALSCM3 resulted in reduced viability in kinetochore mutants, premature separation of sister chromatids, and reduction in Cse4p and histone H4 at centromeres. Overexpression of CSE4 or histone H4 suppressed chromosome loss and restored levels of Cse4p at centromeres in GALSCM3 strains. Using mutant alleles of scm3, we identified a domain in the N-terminus of Scm3p that mediates its interaction with CEN DNA and determined that the chromosome loss phenotype of GALSCM3 is due to centromeric association of Scm3p devoid of Cse4p/H4. Furthermore, we determined that similar to other systems the centromeric association of Scm3p is cell cycle regulated. Our results show that altered stoichiometry of Scm3p/HJURP, Cse4p, and histone H4 lead to defects in chromosome segregation. We conclude that stringent regulation of HJURP and SCM3 expression are critical for genome stability.

  4. Planarian GSK3s are involved in neural regeneration.

    Adell, Teresa; Marsal, Maria; Saló, Emili

    2008-02-01

    Glycogen synthase kinase-3 (GSK3) is a key element in several signaling cascades that is known to be involved in both patterning and neuronal organization. It is, therefore, a good candidate to play a role in neural regeneration in planarians. We report the characterization of three GSK3 genes in Schmidtea mediterranea. Phylogenetic analysis shows that Smed-GSK3.1 is highly conserved compared to GSK3 sequences from other species, whereas Smed-GSK3.2 and Smed-GSK3.3 are more divergent. Treatment of regenerating planarians with 1-azakenpaullone, a synthetic GSK3 inhibitor, suggests that planarian GSK3s are essential for normal differentiation and morphogenesis of the nervous system. Cephalic ganglia appear smaller and disconnected in 1-azakenpaullone-treated animals, whereas visual axons are ectopically projected, and the pharynx does not regenerate properly. This phenotype is consistent with a role for Smed-GSK3s in neuronal polarization and axonal growth. PMID:18202849

  5. Microstructure of interaction interface between Al-Si, Zn-Al alloys and Al2O3p/6061Al composite

    许志武; 闫久春; 吕世雄; 杨士勤

    2004-01-01

    Interaction behaviors between Al-Si, Zn-AI alloys and Al2O3p/6061AI composite at different heating temperatures were investigated. It is found that Al2O3p/6061Al composite can be wetted well by AlSi-1, AlSi-4 and Zn-Al alloys and an interaction layer forms between the alloy and composite during interaction. Little Al-Si alloys remain on the surface when they fully wet the composite and Si element in Al-Si alloy diffuses into composite entirely and assembles in the composite near the interface of Al-Si alloy/composite to form a Si-rich zone. The microstructure in interaction layer with Si penetration is still dense. Much more residual Zn-Al alloy exists on the surface of composite when it wets the composite, and porosities appear at the interface of Zn-Al alloy/composite. The penetration of elements Zn, Cu of Zn-Al alloy into composite leads to the generation of shrinkage cavities in the interaction layer and makes the microstructure of Al2 O3p/6061A1 composite loose.

  6. User access to the MAP3S source emissions inventory

    Benkovitz, C M; Evans, V A

    1981-03-01

    An emissions inventory based on data obtained from the National Emissions Data System (NEDS), the Federal Power Commission (FPC), Environment Canada, and other agencies was compiled by the MAP3S Central Data Coordination at Brookhaven National Laboratory. Pertinent data was brought together, collated, and loaded into computerized data bases using SYSTEM 2000 as the data base management system. These data bases are available to interested users for interactive scanning or batch retrieval. The emissions inventory consists of two distinct sections: a point source inventory and an area source inventory. The point source inventory covers the continental US and Canada; information is kept at the individual source level. The area source inventory covers the continental US; information is kept on a county basis. Work is in progress to obtain a Canadian area source inventory based on census divisions.

  7. Doubly excited 2s2p 1,3p1 resonances in photoionization of helium

    Wan Jian-Jie; Dong Chen-Zhong

    2009-01-01

    The multi-configuration Dirac-Fock (MCDF) method is implemented to study doubly excited 2s2p 1,3P1 resonances of the helium atom and the interference between photoionization and photoexcitation autoionization processes.In order to reproduce the total photoionization sprectra,the excited energies from the ground ls2 1 S0 state to the doubly excited 2s2p 1'3P1 states and the relevant Auger decay rates and widths are calculated in detail. Furthermore,the interference profile determined by the so-called Fano parameters q and p2 is also reproduced. Good agreement is found between the present results and other available theoretical and experimental results. This indeed shows a promising way to investigate the Fano resonances in photoionization of atoms within the MCDF scheme,although there are some discrepancies in the present calculations of the 2s2p 3P1 state.

  8. PbS/Cd3P2 quantum heterojunction colloidal quantum dot solar cells

    Here, we demonstrated the quantum heterojunction colloidal quantum dot (CQD) solar cells employing the PbS CQDs/Cd3P2 CQDs architecture in which both the p-type PbS and n-type Cd3P2 CQD layers are quantum-tunable and solution-processed light absorbers. We synthesized well-crystallized and nearly monodispersed tetragonal Cd3P2 CQDs and then engineered their energy band alignment with the p-type PbS by tuning the dot size and hence the bandgap to achieve efficient light absorbing and charge separation. We further optimized the device through the Ag-doping strategy of PbS CQDs that may leverage an expanded depletion region in the n-layer, which greatly enhances the photocurrent. The resulting devices showed an efficiency of 1.5%. (paper)

  9. A new form of Ca3P2 with a ring of Dirac nodes

    We report the synthesis and crystal structure of a new high-temperature form of Ca3P2. The crystal structure was determined through Rietveld refinements of synchrotron powder x-ray diffraction data. This form of Ca3P2 has a crystal structure of the hexagonal Mn5Si3 type, with a Ca ion deficiency compared to the ideal 5:3 stoichiometry. This yields a stable, charge-balanced compound of Ca2+ and P3−. We also report the observation of a secondary hydride phase, Ca5P3H, which again is a charge-balanced compound. The calculated band structure of Ca3P2 indicates that it is a three-dimensional Dirac semimetal with a highly unusual ring of Dirac nodes at the Fermi level. The Dirac states are protected against gap opening by a mirror plane in a manner analogous to what is seen for graphene

  10. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    Carette, Thomas; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are optimized using the Dirac-Coulomb Hamiltonian with correlation models inspired by the non relativistic calculations. Higher-order excitations are captured through multireference configuration interaction calculations including the Breit interaction. In a third (intermediate) approach, the Dirac-Coulomb-Breit Hamiltonian matrix is diagonalized in a relativistic configuration space built with non relativistic MCHF radial functions converted into Dirac spinors using the Pauli approximation. The magnetic dipole hyperfine struct...

  11. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families

    Kashevarova, Anna A; Nazarenko, Lyudmila P; Schultz-Pedersen, Soren; Skryabin, Nikolay A; Salyukova, Olga A; Chechetkina, Nataliya N; Tolmacheva, Ekaterina N; Rudko, Aleksey A; Magini, Pamela; Graziano, Claudio; Romeo, Giovanni; Joss, Shelagh; Tümer, Zeynep; Lebedev, Igor N

    2014-01-01

    BACKGROUND: Detection of submicroscopic chromosomal alterations in patients with a idiopathic intellectual disability (ID) allows significant improvement in delineation of the regions of the genome that are associated with brain development and function. However, these chromosomal regions usually...... contain several protein-coding genes and regulatory elements, complicating the understanding of genotype-phenotype correlations. We report two siblings with ID and an unrelated patient with atypical autism who had 3p26.3 microdeletions and one intellectually disabled patient with a 3p26.3 microduplication...

  12. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    Wu, Aibing; Jinmei LI; Kunpeng WU; Mo, Yanli; Luo, Yiping; Haiyin YE; Shen, Xiang; Li, Shujun; Yahai LIANG; Liu, Meilian; Yang, Zhixiong

    2015-01-01

    Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC) and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in...

  13. Domain architectures of the Scm3p protein provide insights into centromere function and evolution

    Aravind, L.; Lakshminarayan, M. Iyer; Wu, Carl

    2007-01-01

    Recently, Scm3p has been shown to be a nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3–H4 histones, and to be required for the assembly of kinetochores in S. cerevisiae. Scm3p is conserved across fungi, and displays a remarkable variation in protein size, ranging from ~200 amino acids in Saccharomyces cerevisiae to ~1300 amino acids in Neurospora crassa. This is primarily due a variable C-terminal segment that is linked to a conserved N-terminal, CenH3-int...

  14. Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles.

    Hoebeeck, Jasmien; De Wilde, Bram; Michels, Evi; Combaret, Valérie; Yigit, Nurten; De Smet, Els; Van Roy, Nadine; Stanbridge, Eric; Ru, Ning; Laureys, Geneviève; De Paepe, Anne; Speleman, Frank; Vandesompele, Jo

    2009-10-01

    Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells. PMID:19544108

  15. Oxidation Behavior of a Pd43Cu27Ni10P20 Bulk Metallic Glass and Foam in Dry Air

    Kai, W.; Ren, I. F.; Barnard, B.; Liaw, P. K.; Demetriou, M. D.; Johnson, W. L.

    2010-07-01

    The oxidation behavior of both Pd43Cu27Ni10P20 bulk metallic glass (Pd4-BMG) and its amorphous foam containing 45 pct porosity (Pd4-AF) was investigated over the temperature range of 343 K (70 °C) to 623 K (350 °C) in dry air. The results showed that virtually no oxidation occurred in the Pd4-BMG at T Cu3P, and Pd3P.

  16. Atomic parameters for the 2{p}^{5}3p\\;{}^{2}{[3/2]}_{2}-2{p}^{5}3s\\;{}^{2}{[3/2]}_{2}^{o} transition of Ne I relevant in nuclear physics

    Li, Jiguang; Godefroid, Michel; Wang, Jianguo

    2016-06-01

    We calculated the magnetic dipole hyperfine interaction constants and the electric field gradients of 2{p}53p{}2{[3/2]}2 and 2{p}53s{}2[3/2{]}2o levels of Ne I by using the multiconfiguration Dirac–Hartree–Fock method. The electronic factors contributing to the isotope shifts were also estimated for the λ =614.5 {{nm}} transition connecting these two states. Electron correlation and relativistic effects including the Breit interaction were investigated in detail. Combining with recent measurements, we extracted the nuclear quadrupole moment values for 20Ne and 23Ne with a smaller uncertainty than the current available data. Isotope shifts in the 2{p}53p{}2{[3/2]}2-2{p}53s{}2[3/2{]}2o transition based on the present calculated field- and mass-shift parameters are in good agreement with the experimental values. However, the field shifts in this transition are two or three orders of magnitude smaller than the mass shifts, making rather difficult to deduce changes in nuclear-charge mean-square radii. According to our theoretical predictions, we suggest using instead transitions connecting levels arising from the 2p53s configuration to the ground state, for which the normal mass shift and specific mass shift contributions counteract each other, producing relatively small mass shifts that are only one order of magnitude larger than relatively large field shifts, especially for the 2{p}53s{}2[1/2{]}1o-2{p}6{}1{S}0 transition.

  17. Wetland resources investigation based on 3S technology

    Lin, Hui; Jing, Haitao; Zhang, Lianpeng

    2008-10-01

    Wetland is a special ecosystem between land and water . It can provide massive foods, raw material, water resources and habitat for human being, animals and plants, Wetlands are so important that wetlands' development, management and protection have become the focus of public attention ."3S" integration technology was applied to investigate wetland resources in Shandong Province ,the investigation is based on remote sensing(RS) information, combining wetlandrelated geographic information system(GIS) data concerning existing geology, hydrology, land, lakes, rivers, oceans and environmental protection, using the Global Positioning System (GPS) to determine location accurately and conveniently , as well as multi-source information to demonstrate each other based on "3S" integration technology. In addition, the remote sensing(RS) interpretation shall be perfected by combining house interpretation with field survey and combining interpretation results with known data.By contrasting various types of wetland resources with the TM, ETM, SPOT image and combining with the various types of information, remote sensing interpretation symbols of various types of wetland resources are established respectively. According to the interpretation symbols, we systematically interpret the wetland resources of Shandong Province. In accordance with the purpose of different work, we interpret the image of 1987, 1996 and 2000. Finally, various interpretation results are processed by computer scanning, Vectored, projection transformation and image mosaic, wetland resources distribution map is worked out and wetland resources database of Shandong Province is established in succession. Through the investigation, wetland resource in Shandong province can be divided into 4 major categories and 17 sub-categories. we have ascertained the range and area of each category as well as their present utilization status.. By investigating and calculating, the total area of wetland in Shandong Province is

  18. Electron impact investigation of the 3p-Rydberg transitions of acetone

    High resolution (15 meV), gas phase, electron impact energy loss spectra of acetone, and acetone-d6 measured as a function of incident energy and scattering angle have been used to study the anomalously weak 7.4 eV 3p-Rydberg transition in acetone. Assignments made on the basis of isotope shifts and differential electron scattering cross sections show that the weak transition observed optically and in the high energy electron impact spectrum is a forbidden transition to the out-of-plane 3p-Rydberg orbital. The band system is built on a vibronically allowed false origin enabled by the ν23 (CO bend) vibration. The analogous transition in the less symmetric molecule methyl ethyl ketone was observed to be optically allowed. All observed bands could be assigned to the one electronic transition to the out-of-plane 3p-Rydberg orbital. The other two 3p-Rydberg transitions do not appear to be active in acetone or methyl ethyl ketone. An unusual feature of this investigation was the experimental investigation of the relative differential scattering cross sections of both true and false vibronic origins within a single electronic transition. The high energy resolution allowed isotopic substitution, a traditional technique of optical spectroscopy, to be used to establish assignments in an electron impact experiment

  19. Canine-Origin G3P[3] Rotavirus Strain in Child with Acute Gastroenteritis

    De Grazia, Simona; Martella, Vito; Giammanco, Giovanni M; Gòmara, Miren Iturriza; Ramirez, Stefania; Cascio, Antonio; Colomba, Claudia; Arista, Serenella

    2007-01-01

    Infection by an animal-like strain of rotavirus (PA260/97) was diagnosed in a child with gastroenteritis in Palermo, Italy, in 1997. Sequence analysis of VP7, VP4, VP6, and NSP4 genes showed resemblance to a G3P[3] canine strain identified in Italy in 1996. Dogs are a potential source of human viral pathogens.

  20. miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation

    Qiu, Weimin; Kassem, Moustapha

    2014-01-01

    Wnt signaling determines human stromal (mesenchymal) stem cell (hMSC) differentiation fate into the osteoblast or adipocyte lineage. microRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate many aspects of osteoblast biology. Thus, we examined miRNAs regulated by Wnt signaling...... in hMSC. We identified miRNA (miR)-141-3p as a Wnt target which in turn inhibited Wnt signaling. Moreover, miR-141-3p inhibited hMSC proliferation by arresting cells at the G1 phase of the cell cycle. miR-141-3p inhibited osteoblast differentiation of hMSC as evidenced by reduced alkaline phosphatase...... activity, gene expression and in vitro mineralized matrix formation. Bioinformatic studies, Western blot analysis and 3'UTR reporter assay demonstrated that cell division cycle 25A (CDC25A) is a direct target of miR-141-3p. siRNA-mediated knock-down of CDC25A inhibited hMSC proliferation and osteoblast...

  1. miR-200a-3p regulates TLR1 expression in bacterial challenged miiuy croaker.

    Wang, Yanjin; Xu, Guoliang; Han, Jingjing; Xu, Tianjun

    2016-10-01

    MicroRNAs (miRNAs) are highly conserved, small non-coding RNAs which post-transcriptionally regulate various biological processes by repressing mRNA translation or degradating mRNA. It has been demonstrated that miRNAs play crucial roles in regulating the immune system. In this study, we explored the potential roles of miR-200a-3p in regulating TLR signaling pathway in miiuy croaker. Bioinformatics analysis showed that miiuy croaker TLR1 (mmiTLR1) was a putative target of miR-200a-3p. Negative expression profiles in spleen of Vibrio anguillarum challenged miiuy croaker and in lipopolysaccharide (LPS) stimulated miiuy croaker leukocytes further validated the prediction. Luciferase reporter assays showed that the dual-luciferase reporter fused to the 3'UTR of wild type mmiTLR1 cotransfected with miR-200a-3p mimics exhibited a reduction in luciferase activity compared with the controls. All of the present data provide direct evidence that miR-200a-3p is involved in TLR1 expression modulation in miiuy croaker, which will offer a basis for better understanding of miRNA regulation in fish TLR signaling pathways. PMID:27288848

  2. Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21

    Christensen, Ulla; Møller-Larsen, Steffen; Nyegaard, Mette;

    2009-01-01

    Atopic dermatitis (AD) is a common, itchy skin disease of complex inheritance characterized by dermal and epidermal inflammation. The heritability is considerable and well documented. To date, four genome scans have examined the AD phenotype, showing replicated linkage at 3p26-22, 3q13-21 and 18q11...

  3. $\\beta$3p- spectroscopy and P-$\\gamma$ width determination in the decay of $^{31}$Ar

    We propose to perform a detailed study of the $\\beta$-decay of the dripline nucleus $^{31}$Ar. This will allow a detailed study of the $\\beta$-delayed 3p-decay as well as provide important information on the resonances of $^{30}$S and $^{29}$P, in particular the ratio between the P- and $\\gamma$- partial widths relevant for astrophysics.

  4. miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

    Mario Leonardo Squadrito

    2012-02-01

    Full Text Available Expression of the mannose receptor (MRC1/CD206 identifies macrophage subtypes, such as alternatively activated macrophages (AAMs and M2-polarized tumor-associated macrophages (TAMs, which are endowed with tissue-remodeling, proangiogenic, and protumoral activity. However, the significance of MRC1 expression for TAM's protumoral activity is unclear. Here, we describe and characterize miR-511-3p, an intronic microRNA (miRNA encoded by both mouse and human MRC1 genes. By using sensitive miRNA reporter vectors, we demonstrate robust expression and bioactivity of miR-511-3p in MRC1+ AAMs and TAMs. Unexpectedly, enforced expression of miR-511-3p tuned down the protumoral gene signature of MRC1+ TAMs and inhibited tumor growth. Our findings suggest that transcriptional activation of Mrc1 in TAMs evokes a genetic program orchestrated by miR-511-3p, which limits rather than enhances their protumoral functions. Besides uncovering a role for MRC1 as gatekeeper of TAM's protumoral genetic programs, these observations suggest that endogenous miRNAs may operate to establish thresholds for inflammatory cell activation in tumors.

  5. 3P2-3F2 pairing in dense neutron matter: the spectrum of solutions

    The 3P2-3F2 pairing model is generally considered to provide an adequate description of the superfluid states of neutron matter at densities some 2-3 times that of saturated symmetrical nuclear matter. The problem of solving the system of BCS gap equations expressing the 3P2-3F2 model is attacked with the aid of the separation approach. This method, developed originally for quantitative study of S-wave pairing in the presence of strong short-range repulsions, serves effectively to reduce the coupled, singular, nonlinear BCS integral equations to a set of coupled algebraic equations. For the first time, sufficient precision becomes accessible to resolve small energy splittings between the different pairing states. Adopting a perturbative strategy, we are able to identify and characterize the full repertoire of real solutions of the 3P2-3F2 pairing model, in the limiting regime of small tensor-coupling strength. The P-F channel coupling is seen to lift the striking parametric degeneracies revealed by a earlier separation treatment of the pure, uncoupled 3P2 pairing problem. Remarkably, incisive and robust results are obtained solely on the basis of analytic arguments. Unlike the traditional Ginzburg-Landau approach, the analysis is not restricted to the immediate vicinity of the critical temperature, but is equally reliable at zero temperature. Interesting connections and contrasts are drawn between triplet pairing in dense neutron matter and triplet pairing in liquid 3He

  6. On the magnetocrystalline anisotropy of greigite (Fe3S4)

    Winklhofer, Michael; Chang, Liao; Eder, Stephan H. K.

    2014-04-01

    ferrimagnetic mineral greigite (cubic Fe3S4) is well known as an intracellular biomineralization product in magnetic bacteria and as a widely occurring authigenic mineral in anoxic sediments. Due to the lack of suitable single-crystal specimens, the magnetic anisotropy parameters of greigite have remained poorly constrained, to the point where not even the easy axis of magnetization is known. Here we report on an effort to determine the anisotropy parameters on the basis of ferromagnetic resonance (FMR) powder spectroscopy on hydrothermally synthesized, chemically pure greigite microcrystals dispersed in a nonmagnetic matrix. In terms of easy axis orientations, the FMR data are consistent with or , or less likely, a more general type. With a g factor of 2.09, the anisotropy field is about 90 mT and in some samples may reach 125 mT, compared to 30 mT for cubic magnetite. This confirms the dominating role of cubic anisotropy on the magnetic properties of greigite, which we show to be responsible for large SIRM/k values. K1 is in the range -15 … -23 J/m3 () or +10 … +15 kJ/m3 (), yielding upper limits of 44 or 34 nm for the superparamagnetic grain size, respectively.

  7. Current challenges with understanding greigite (Fe3S4) magnetism

    Chang, L.; Roberts, A. P.; Winklhofer, M.; Vasiliev, I.; Dekkers, M. J.; Krijgsman, W.

    2014-12-01

    Greigite (Fe3S4) is a widespread authigenic magnetic mineral in anoxic sediments, and is also commonly biosynthesized by magnetotactic bacteria in aqueous environments. Despite the importance of greigite in paleomagnetic and environmental magnetic studies, knowledge of its magnetic properties is at a much lower level than for more common rock-forming magnetic minerals. Much recent progress has been made to develop a more complete understanding of the magnetic properties of greigite and the range of grain sizes in which greigite occurs in nature. We present results of new determinations of a range of fundamental magnetic properties of greigite, including the saturation magnetization, the magnetocrystalline anisotropy, and calculated rock magnetic properties. In addition, we provide evidence for the preservation of greigite magnetofossils in ancient sediments, which has important implications for assessing the reliability of paleomagnetic records carried by greigite. Finally, we present an integrated study from a Messinian former Black Sea sedimentary sequence to unravel environmental controls on diagenetic greigite formation, and demonstrates the usefulness of greigite for studying long-term climate variability in anoxic environments.

  8. 3S-R10 automated RBS system

    Norton, G. A.; Schroeder, J. B.; Klody, G. M.; Strathman, M. D.

    1989-04-01

    The NEC 3S-R10 automated RBS spectrometer system includes the features required for routine application of Rutherford backscattering (RBS) and related techniques for materials analysis in both research and industrial settings. The NEC Model 3SDH Pelletron accelerator system provides stable, monoenergetic beams of helium ions up to 3.3 MeV and protons to 2.2 MeV and has heavy ion capability. The analytical end station is the fully computerized Charles Evans & Associates Model RBS-400. Automated features include sample positioning (precision 4-axis goniometer), channeling alignment, polar plot generation, and data acquisition and reduction. Computer automation of accelerator and chamber functions includes storage and recall of operating parameters. Unattended data acquisition, e.g., overnight or over a weekend, is possible for up to 100 samples per batch for random orientation, rotating random or channeling analyses at any sample location. Single samples may be up to 50 cm in diameter. A laser for sample alignment and a TV for video monitoring are included. Simultaneous detection (up to 4 detectors) at normal and grazing angles, external control of grazing angle detector position, and transmission scattering capability enhance system flexibility. The system is also compatible with PIXE, NRA, and hydrogen forward-scattering analyses. Data reduction is part of the computer system, which features displays (several formats) and manipulation of up to five spectra at one time using constant multipliers or point by point operations between spectra.

  9. The Euratom Treaty and the 3S approach

    The 3S concept concerns the adoption of an approach by national authorities to legislation and regulation in the areas of nuclear safety, security, and safeguards which treats these closely related areas in an integrated fashion, rather than as three separate Islands. The benefits from adopting such an integrated approach lire the avoidance of legislative or regulatory gaps, and what is equally important: the avoidance of legislative or regulatory overlaps - particularly where conflicts may be concerned. The European Union possesses extensive legislative competences in relation to protecting the health and safety of workers and the public against Ionizing radiation. It also possesses competences in relation to ensuring that nuclear materials are not diverted from their declared uses. In both of these areas there is a nexus with the security of nuclear materials end radioactive materials more generally. The European Commission is currently elaborating a legislative proposal to consolidate the European Basic Standards legislation, which includes the Directive on the control of High Activity Sealed Sources, into a single, integrated legal Instrument. This paper also takes note of current activities in the area of safeguards, which although intended to improve safeguards controls, are also expected to improve security of nuclear materials in the EU. The paper also briefly analyses overlaps between safeguards and safety. (author)

  10. The valence band electronic structure of the Cu(111) (√3X√3)R30deg-Si interface

    Full text: The structure and bonding of the copper-silicon interface is of considerable interest from a number of aspects. Firstly as a catalyst in the commercial synthesis of silane polymers, secondly as an anti-corrosion treatment, and thirdly, the formation of a well ordered and reactive silicon layer, which can be oxidised is relevant in the creation of ultra-thin silicon oxide-metal interfaces for electronic devices. Silicon is capable of forming a number of compounds with copper, the most widely studied of which is Cu3Si. Calculations have shown that when silicon impurity atoms are incorporated into a copper solid, there is an interaction between copper 3d levels and the 3s and sp levels of silicon. The silicon 2p orbitals rehybridise with the copper 3d band to form bonding and antibonding states separated by -4 eV. The resulting compounds have metallic, rather than semiconducting nature, there is charge transfer from copper to silicon and there is an increase in electron density into the silicon valence bands, making silicon more reactive. The splitting of the density of states near the Fermi edge has been measured as 4-5 eV in amorphous copper-silicon alloys, using Si Kβ fluorescence spectroscopy and has also been inferred from the 4 eV splitting of the LV V auger lines in Cu-Si compounds and in copper deposited on Si(100) and Si(111) surfaces. In this study we have used high resolution valence band photoemission spectroscopy to investigate the nature of the silicon valence bands in a well ordered silicon-copper interface. By comparing the valence band spectra of the clean surface and those from the silicon interface, we are able to identify three silicon-derived features which are in agreement with other published data. We suggest that these levels are due to emission from the 3s and 3p levels of Si

  11. Photoelectric characteristics of CH3NH3PbI3/p-Si heterojunction

    Yamei, Wu; Ruixia, Yang; Hanmin, Tian; Shuai, Chen

    2016-05-01

    Organic–inorganic hybrid perovskite CH3NH3PbI3 film is prepared on p-type silicon substrate using the one-step solution method to form a CH3NH3PbI3/p-Si heterojunction. The film morphology and structure are characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The photoelectric properties of the CH3NH3PbI3/p-Si heterojunction are studied by testing the current–voltage (I–V) with and without illumination and capacitance–voltage (C–V) characteristics. It turns out from the I–V curve without illumination that the CH3NH3PbI3/p-Si heterojunction has a rectifier feature with the rectification ratio over 70 at the bias of ±5 V. Also, there appears a photoelectric conversion phenomenon on this heterojunction with a short circuit current (Isc) of 0.16 μA and an open circuit voltage (Voc) of about 10 mV The high frequency C–V characteristic of the Ag/CH3NH3PbI3/p-Si heterojunction turns out to be similar to that of the metal–insulator–semiconductor (MIS) structure, and a parallel translation of the C–V curve along the forward voltage axis is found. This parallel translation means the existence of defects at the CH3NH3PbI3/p-Si interface and positive fixed charges in the CH3NH3PbI3 layer. The defects at the interface of the CH3NH3PbI3/p-Si heterojunction result in the dramatic decline of the Voc. Besides, the C–V test of CH3NH3PbI3 film shows a non-linear dielectric property and the dielectric value is about 4.64 as calculated. Project supported by the Hebei Province Natural Science Foundation of China (No. F2014202184) and the Tianjin Natural Science Foundation of China (No. 15JCZDJC37800).

  12. Gamma-ray irradiation induced bulk photochromism in WO3-P2O5 glass

    Shen, Wei; Baccaro, Stefania; Cemmi, Alessia; Xu, Xiaoqing; Chen, Guorong

    2015-11-01

    In the present work, photochromism of WO3-P2O5 glass under gamma-ray irradiation was reported. As-prepared glass samples with different WO3 content are all optically transparent in the visible wavelength range thanks to the addition of a small amount of oxidizing couple Sb2O3-NaNO3. The photochromic properties are identified by transmission spectra of the glasses before and after irradiation. The results show that the irradiation induced darkening results from the reduction of W6+ to W5+ or W4+. The existence of WO6 clusters in glasses of high WO3 content is proved by XPS, which is the main reason for the obvious photochromic effects. The WO3-P2O5 glass is a promising candidate in gamma-ray sensitive detector.

  13. Parallel 3D Finite Element Particle-in-Cell Simulations with Pic3P

    Candel, A.; Kabel, A.; Lee, L.; Li, Z.; Ng, C.; Schussman, G.; Ko, K.; /SLAC; Ben-Zvi, I.; Kewisch, J.; /Brookhaven

    2009-06-19

    SLAC's Advanced Computations Department (ACD) has developed the parallel 3D Finite Element electromagnetic Particle-In-Cell code Pic3P. Designed for simulations of beam-cavity interactions dominated by space charge effects, Pic3P solves the complete set of Maxwell-Lorentz equations self-consistently and includes space-charge, retardation and boundary effects from first principles. Higher-order Finite Element methods with adaptive refinement on conformal unstructured meshes lead to highly efficient use of computational resources. Massively parallel processing with dynamic load balancing enables large-scale modeling of photoinjectors with unprecedented accuracy, aiding the design and operation of next-generation accelerator facilities. Applications include the LCLS RF gun and the BNL polarized SRF gun.

  14. Ca3P2 and other topological semimetals with line nodes and drumhead surface states

    Chan, Y.-H.; Chiu, Ching-Kai; Chou, M. Y.; Schnyder, Andreas P.

    2016-05-01

    As opposed to ordinary metals, whose Fermi surfaces are two dimensional, topological (semi)metals can exhibit protected one-dimensional Fermi lines or zero-dimensional Fermi points, which arise due to an intricate interplay between symmetry and topology of the electronic wave functions. Here, we study how reflection symmetry, time-reversal symmetry, SU(2) spin-rotation symmetry, and inversion symmetry lead to the topological protection of line nodes in three-dimensional semimetals. We obtain the crystalline invariants that guarantee the stability of the line nodes in the bulk and show that a quantized Berry phase leads to the appearance of protected surfaces states, which take the shape of a drumhead. By deriving a relation between the crystalline invariants and the Berry phase, we establish a direct connection between the stability of the line nodes and the drumhead surface states. Furthermore, we show that the dispersion minimum of the drumhead state leads to a Van Hove singularity in the surface density of states, which can serve as an experimental fingerprint of the topological surface state. As a representative example of a topological semimetal, we consider Ca3P2 , which has a line of Dirac nodes near the Fermi energy. The topological properties of Ca3P2 are discussed in terms of a low-energy effective theory and a tight-binding model, derived from ab initio DFT calculations. Our microscopic model for Ca3P2 shows that the drumhead surface states have a rather weak dispersion, which implies that correlation effects are enhanced at the surface of Ca3P2 .

  15. Temperature dependence and mechanism of the reaction between O(3P) and chlorine dioxide

    Colussi, A. J.; Sander, S. P.; Fiedl, R. R.

    1992-01-01

    Second-order rate constants for the decay of O(3P) in excess chlorine dioxide, k(II), were measured as a function of total pressure (20-600 Torr argon) and temperature (248-312 K), using flash photolysis-atomic resonance fluorescence. Results indicate that k(II) is pressure dependent with a value, K(b), that is nonzero at zero pressure, and both the third-order rate constant and k(b) have negative temperature dependences.

  16. The Participative Design of an Endoscopy Facility using Lean 3P.

    Smith, Iain

    2016-01-01

    In the UK, bowel cancer is the second largest cancer killer. Diagnosing people earlier can save lives but demand for endoscopies is increasing and this can put pressure on waiting times. To address this challenge, an endoscopy unit in North East England decided to improve their facilities to increase capacity and create environments that improve the experience of users. This presented a significant opportunity for step change improvement but also a problem in terms of creating designs that meet user requirements whilst addressing structural or space constraints. The Lean design process known as '3P' (standing for the production preparation process) was utilised as a participative design strategy to engage stakeholders in the design of the new department. This involved a time-out workshop (or 3P event) in which Lean and participative design tools were utilised to create an innovative design based on 'point of delivery' (POD) principles. The team created a design that demonstrated an increase in treatment room capacity by 25% and bed capacity by 70% whilst reducing travel distance for patients by 25.8% and staff by 27.1%. This was achieved with an increase in available space of only 13%. The Lean 3P method provided a structured approach for corporate and clinical staff to work together with patient representatives as cross-functional teams. This participative approach facilitated communication and learning between stakeholders about care processes and personal preferences. Lean 3P therefore appears to be a promising approach to improving the healthcare facilities design process to meet user requirements. PMID:27493744

  17. Omega3P: A Parallel Finite-Element Eigenmode Analysis Code for Accelerator Cavities

    Lee, Lie-Quan; Li, Zenghai; Ng, Cho; Ko, Kwok; /SLAC

    2009-03-04

    Omega3P is a parallel eigenmode calculation code for accelerator cavities in frequency domain analysis using finite-element methods. In this report, we will present detailed finite-element formulations and resulting eigenvalue problems for lossless cavities, cavities with lossy materials, cavities with imperfectly conducting surfaces, and cavities with waveguide coupling. We will discuss the parallel algorithms for solving those eigenvalue problems and demonstrate modeling of accelerator cavities through different examples.

  18. $^3P_2$-$^3F_2$ Pairing in Dense Neutron Matter The Spectrum of Solutions

    Zverev, M V; Khodel, V A

    2003-01-01

    The $^3P_2$-$^3F_2$ pairing model is generally considered to provide an adequate description of the superfluid states of neutron matter at densities some 2-3 times that of saturated symmetrical nuclear matter. The problem of solving the system of BCS gap equations expressing the $^3P_2$-$^3F_2$ model is attacked with the aid of the separation approach. This method, developed originally for quantitative study of S-wave pairing in the presence of strong short-range repulsions, serves effectively to reduce the coupled, singular, nonlinear BCS integral equations to a set of coupled algebraic equations. For the first time, sufficient precision becomes accessible to resolve small energy splittings between the different pairing states. Adopting a perturbative strategy, we are able to identify and characterize the full repertoire of real solutions of the $^3P_2$-$^3F_2$ pairing model, in the limiting regime of small tensor-coupling strength. The P-F channel coupling is seen to lift the striking parametric degeneracie...

  19. Study of the Ne(^3P_2) + CH_3F Electron Transfer Reaction below 1 Kelvin

    Jankunas, Justin; Osterwalder, Andreas

    2014-01-01

    Relatively little is known about the dynamics of electron transfer reactions at low collision energy. We present a study of Penning ionization of ground state methyl fluoride molecules by electronically excited neon atoms in the 13 $\\mu$eV--4.8 meV (150 mK--56 K) collision energy range, using a neutral-neutral merged beam setup. Relative cross sections have been measured for three Ne($^3P_2$)+ CH$_3$F reaction channels by counting the number of CH$_3$F$^+$, CH$_2$F$^+$, and CH$_3^+$ product ions, as a function of relative velocity between the neon and methyl fluoride molecular beams. Experimental cross sections markedly deviate from the Langevin capture model at collision energies above 20 K. The branching ratios are constant. In other words, the chemical shape of the CH$_3$F molecule, as seen by Ne($^3P_2$) atom, appears not to change as the collision energy is varied, in contrast to related Ne($^3P_J$) + CH$_3$X (X=Cl and Br) reactions at higher collision energies.

  20. Phase transitions in Cd3P2 at high pressures and high temperatures

    Yel'kin, F.S.; Sidorov, V.A.; Waskowska, A.;

    2008-01-01

    The high-pressure, high-temperature structural behaviour of Cd3P2 has been studied using electrical resistance measurements, differential thermal analysis, thermo baric analysis and X-ray diffraction. At room temperature, a phase transformation is observed at 4.0 GPa in compression. The experimen......The high-pressure, high-temperature structural behaviour of Cd3P2 has been studied using electrical resistance measurements, differential thermal analysis, thermo baric analysis and X-ray diffraction. At room temperature, a phase transformation is observed at 4.0 GPa in compression....... The experimental zero-pressure bulk modulus of the low-pressure phase is 64.7(7) GPa, which agrees quite well with the calculated value of 66.3 GPa using the tight-binding linear muffin-tin orbital method within the local density approximation. Tentatively, the high-pressure phase has an orthorhombic crystal...... structure with space group Pmmn (#59). The relative volume change at the phase transition is Delta V/V= -5.5%. Amorphization of the sample occurs above 25 GPa. A P-T phase diagram of Cd3P2 has been constructed. A metastable phase is observed at ambient conditions after heating the sample to above 600 K...

  1. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae.

    Manabe, Kunio; Kawano-Kawada, Miyuki; Ikeda, Koichi; Sekito, Takayuki; Kakinuma, Yoshimi

    2016-06-01

    The vacuolar membrane proteins Ypq1p, Ypq2p, and Ypq3p of Saccharomyces cerevisiae are known as the members of the PQ-loop protein family. We found that the ATP-dependent uptake activities of arginine and histidine by the vacuolar membrane vesicles were decreased by ypq2Δ and ypq3Δ mutations, respectively. YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Δ and ypq3Δ. The vacuolar membrane vesicles isolated from the resulting quadruple deletion mutant ypq1Δypq2Δypq3Δavt1Δ completely lost the uptake activity of basic amino acids, and that of histidine, but not lysine and arginine, was evidently enhanced by overexpressing YPQ3 in the mutant. These results suggest that Ypq3p is specifically involved in the vacuolar uptake of histidine in S. cerevisiae. The cellular level of Ypq3p-HA(3) was enhanced by depletion of histidine from culture medium, suggesting that it is regulated by the substrate. PMID:26928127

  2. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway

    Zhao, Liang; Zhang, Yubao, E-mail: zhyb880077@sina.com

    2015-02-13

    Recent research indicates that non-coding microRNAs (miRNAs) help regulate basic cellular processes in many types of cancer cells. We hypothesized that overexpression of miR-342-3p might affect proliferation of hepatocellular carcinoma (HCC) cells. After confirming overexpression of miR-342-3p with qRT-PCR, MTT assay showed that HCC cell proliferation was significantly inhibited by miR-342-3p, and that it significantly decreased BrdU-positive cell proliferation by nearly sixfold. Searching for targets using three algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes. Results of western blot on extracted nuclear proteins of HepG2 and HCT-116 cells showed that miR-342-3p reduced and miR-342-3p-in increased p65 nuclear levels and qRT-PCR found that NF-κB pathway downstream genes were downregulated by miR-342-3p and upregulated by miR-342-3p-in, confirming that miR-342 targets NF-κB pathway. Overexpression of Ikk-γ, TAB2 and TAB3 partially rescued HCC cells proliferation inhibited by miR-342-3p. Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples. Our results show that miR-342-3p has a significant role in HCC cell proliferation and is suitable for investigation of therapeutic targets. - Highlights: • MiR-342-3p suppresses hepatocellular carcinoma cell proliferation. • MiR-342-3p targets IKK-γ, TAB2 and TAB3 genes. • MiR-342-3p downregulates NF-kB signaling pathway. • MiR-342-3p is downregulated in clinical hepatocellular carcinoma samples. • The expression of miR-342-3p and its target gene is inversely related.

  3. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway

    Recent research indicates that non-coding microRNAs (miRNAs) help regulate basic cellular processes in many types of cancer cells. We hypothesized that overexpression of miR-342-3p might affect proliferation of hepatocellular carcinoma (HCC) cells. After confirming overexpression of miR-342-3p with qRT-PCR, MTT assay showed that HCC cell proliferation was significantly inhibited by miR-342-3p, and that it significantly decreased BrdU-positive cell proliferation by nearly sixfold. Searching for targets using three algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes. Results of western blot on extracted nuclear proteins of HepG2 and HCT-116 cells showed that miR-342-3p reduced and miR-342-3p-in increased p65 nuclear levels and qRT-PCR found that NF-κB pathway downstream genes were downregulated by miR-342-3p and upregulated by miR-342-3p-in, confirming that miR-342 targets NF-κB pathway. Overexpression of Ikk-γ, TAB2 and TAB3 partially rescued HCC cells proliferation inhibited by miR-342-3p. Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples. Our results show that miR-342-3p has a significant role in HCC cell proliferation and is suitable for investigation of therapeutic targets. - Highlights: • MiR-342-3p suppresses hepatocellular carcinoma cell proliferation. • MiR-342-3p targets IKK-γ, TAB2 and TAB3 genes. • MiR-342-3p downregulates NF-kB signaling pathway. • MiR-342-3p is downregulated in clinical hepatocellular carcinoma samples. • The expression of miR-342-3p and its target gene is inversely related

  4. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

    Zhai, Qingna [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China); Zhou, Liang [Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Guangdong (China); Zhao, Chunjuan [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China); Wan, Jun [Section of Biochemistry and Cell Biology, Division of Life Science, The Hong Kong University of Science and Technology (Hong Kong); Yu, Zhendong, E-mail: zhendongyu66@hotmail.com [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Guo, Xin; Qin, Jie; Chen, Jing [Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Guangdong (China); Lu, Ruijing [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China)

    2012-03-23

    Highlights: Black-Right-Pointing-Pointer Previous method was the second-generation sequencing technology. Black-Right-Pointing-Pointer miR-508-3p and miR-509-3p were significantly down-regulated in RCC tissues. Black-Right-Pointing-Pointer They can inhibit cell proliferation and migration and promote cell apoptosis. Black-Right-Pointing-Pointer The expression of miR-508-3p was significantly decreased in RCC patients plasma. Black-Right-Pointing-Pointer miR-508-3p may be a novel diagnostic marker of RCC. -- Abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.

  5. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

    Highlights: ► Previous method was the second-generation sequencing technology. ► miR-508-3p and miR-509-3p were significantly down-regulated in RCC tissues. ► They can inhibit cell proliferation and migration and promote cell apoptosis. ► The expression of miR-508-3p was significantly decreased in RCC patients plasma. ► miR-508-3p may be a novel diagnostic marker of RCC. -- Abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.

  6. Theoretical study of intramultiplet transitions in collisions of atoms in 3P electronic states with structureless targets: Ca(3P)+He

    The quantum close-coupling (CC) treatment of collisions of an atom in a 3P electronic state with a structureless target is developed, based on earlier work of Mies [Phys. Rev. A 7, 942 (1973)], and a j/sub z/-conserving [coupled-states (CS)] simplification presented. There is no direct coupling between the J = 0 and J = 1 levels; transitions between these levels will occur only as a result of Coriolis coupling involving the J = 2 state. Actual CC and CS calculations are reported for collisions of Ca 43P/sup o/ with He, based on the potential curves of Malvern [J. Phys. B 11, 831 (1978)]. In the CC results, of the three independent cross sections, J = 2→1 is predicted to be largest, and J = 2→0 smallest, over the entire range of collision energies sampled. By contrast, the CS approximation predicts the 1→0 transition to be forbidden, and yields only fair accuracy for the CC 2→1 and 2→0 transitions. The coupling between spin-orbit states is also interpreted within an adiabatic model. A comparison with the experimental results of Yuh and Dagdigian (preceding paper) is made by averaging the CC cross sections over the experimental translational energy distribution. The experimental cross sections for the 2→1 and 2→0 transitions are 3--4 times larger than the theoretical values, and the 2→0 cross section is found experimentally to be approx.3 times larger than the 1→0 cross section, in direct contrast with the theoretical prediction for this ratio

  7. Spectra of identified high-p(T) pi(+/-) and p((p)over-bar ) in Cu + Cu collisions at root s(NN)=200 GeV

    Abelev, B. I.; Aggarwal, M. M.; Ahammed, Z.; Alakhverdyants, A. V.; Anderson, B. D.; Arkhipkin, D.; G.S. Averichev; Balewski, J.; Barnby, L.S.; Baumgart, S.; Beavis, D.R.(Brookhaven National Laboratory, Upton, NY, 11973, USA); Bellwied, R.; Benedosso, F.; Betancourt, M. J.; Betts, R. R.

    2010-01-01

    We report new results on identified (anti) proton and charged pion spectra at large transverse momenta (3 < p(T) < 10 GeV/c) from Cu + Cu collisions at root s(NN) = 200 GeV using the STAR detector at the Relativistic Heavy Ion Collider (RHIC). This study explores the system size dependence of two novel features observed at RHIC with heavy ions: the hadron suppression at high-p(T) and the anomalous baryon to meson ...

  8. Study of Υ(3S,2S)→ηΥ(1S) and Υ(3S,2S)→π+π-Υ(1S) hadronic transitions

    BABAR Collection; Lees, J. P.; Poireau, V.; Tisserand, V.; Snoek, H.; et al

    2011-01-01

    We study the Υ(3S,2S)→ηΥ(1S) and Υ(3S,2S)→π+π-Υ(1S) transitions with 122×106Υ(3S) and 100×106Υ(2S) mesons collected by the BABAR detector at the PEP-II asymmetric-energy e+e- collider. We measure B[Υ(2S)→ηΥ(1S)]=(2.39±0.31(stat.)±0.14(syst.))×10-4 and Γ[Υ(2S)→ηΥ(1S)]/Γ[Υ(2S)→π+π-Υ(1S)]=(1.35±0.17(stat.)±0.08(syst.))×10-3. We find no evidence for Υ(3S)→ηΥ(1S) and obtain B[Υ(3S)→ηΥ(1S)

  9. Dsj meson decay in the C{sup 3}P{sub 0} model

    Silva, D.T. da; Silva, M.L.L. da; Quadros, J.N. de; Vasconcellos, C.A.Z.; Hadjimichef, D. [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil)

    2010-07-01

    Full text. Fock-Tani is a field theory formalism appropriated for the simultaneous treatment of composite particles and their constituents. The formalism was originally developed for the treatment of problems in atomic physics and it was extended later on to the treatment of problems on hadron physics. In the Fock-Tani formalism one starts with the Fock representation of the system using field operators of elementary constituents which satisfy canonical (anti) commutation relations. Composite-particle field operators are linear combinations of the elementary-particle operators and do not generally satisfy canonical (anti) commutation relations. 'Ideal' field operators acting on an enlarged Fock space are then introduced in close correspondence with the composite ones. Next, a given unitary transformation, which transforms the single composite states into single ideal states, is introduced. Application of the unitary operator on the microscopic Hamiltonian, or on other hermitian operators expressed in terms of the elementary constituent field operators, gives equivalent operators which contain the ideal field operators. The effective Hamiltonian in the new representation has a clear physical interpretation in terms of the processes it describes. Since all field operators in the new representation satisfy canonical (anti)commutation relations, the standard methods of quantum field theory can then be readily applied. For a long time the pair creation models for strong hadronic decays have been formulated. The {sup 3}P{sub 0} model is typical decay model which considers only OZI-allowed strong decays. The {sup 3}P{sub 0} model considers a quark-antiquark par creation in the presence of the initial state meson. The quark-antiquark par is created with the vacuum quantum numbers. This model can also be obtained from the non-relativistic limit of the pair creation Hamiltonian. Applying the Fock-Tani transformation to the pair creation Hamiltonian produces the

  10. MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.

    Fordham, Jezrom B; Guilfoyle, Katherine; Naqvi, Afsar Raza; Nares, Salvador

    2016-01-01

    MicroRNA are small, non-coding, single-stranded RNAs that are estimated to regulate ~60% of the human genome. MiRNA profiling of monocyte-to-osteoclast differentiation identified miR-142-3p as a miRNA that is significantly, differentially expressed throughout osteoclastogenesis. Enforced expression of miR-142-3p via transient transfection with miR-142-3p mimic inhibited cell-to-cell contact and fusion, decreased protein kinase C alpha expression, and ultimately reduced cell viability. miR-142-3p was also identified as significantly differentially expressed during monocyte-to-macrophage differentiation and overexpression of miR-142-3p prevented their conversion to osteoclasts. Furthermore, the inhibitory effect of miR-142-3p on osteoclastogenesis extended to the conversion of a third osteoclast precursor cell type- dendritic cells. These results demonstrate miR-142-3p to be a negative regulator of osteoclastogenesis from the 3 main precursor cell types: monocytes, macrophages and dendritic cells. Importantly, decreased survival was dependent upon both miR-142-3p expression and RANK-signaling, with no harmful effects detected in the absence of this combination. As such, miR-142-3p represents a novel target for the selective removal of osteoclasts by targeting of osteoclastogenic pathways. PMID:27113904

  11. MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-δ1.

    Wu, Shifeng; Du, Xinjie; Wu, Manwu; Du, Hechun; Shi, Xiaoliang; Zhang, Tao

    2016-06-10

    Osteosarcoma is the most common primary bone cancer which is associated with early metastatic potential and poor prognosis. However, the molecular mechanisms underlying osteosarcoma progression are not well characterized. Here, we investigated the role of miR-409-3p in osteosarcoma metastasis. Osteosarcoma tissue showed decreased expression of miR-409-3p compared to adjacent non-tumorous tissue. The expression level of miR-409-3p was negatively correlated with osteosarcoma metastasis. Overexpression of miR-409-3p in osteosarcoma cells (U2OS) inhibited cell migration and invasion. Bioinformatics analysis showed that catenin-δ1 (CTNND1, p120-catenin) is a direct target of miR-409-3p. Overexpression of miR-409-3p repressed the expression of catenin-δ1 in U2OS cells at both mRNA and protein levels. Meanwhile, miR-409-3p repressed the activity of luciferase reporter containing the 3'-untranslated region (3'UTR) of CTNND1 gene. Furthermore, expression of catenin-δ1 rescued the inhibitory effect of miR-409-3p on cell migration and invasion. Altogether, these results indicated that miR-409-3p targets catenin-δ1 to repress osteosarcoma metastasis. PMID:26992637

  12. A quasi-particle description of the M(3,p) models

    Jacob, P.; Mathieu, P

    2005-01-01

    The M(3,p) minimal models are reconsidered from the point of view of the extended algebra whose generators are the energy-momentum tensor and the primary field \\phi_{2,1} of dimension $(p-2)/4$. Within this framework, we provide a quasi-particle description of these models, in which all states are expressed solely in terms of the \\phi_{2,1}-modes. More precisely, we show that all the states can be written in terms of \\phi_{2,1}-type highest-weight states and their phi_{2,1}-descendants. We fu...

  13. Absolute frequency measurement of the 1S0 - 3P0 transition of 171Yb

    Pizzocaro, Marco; Rauf, Benjamin; Bregolin, Filippo; Milani, Gianmaria; Clivati, Cecilia; Costanzo, Giovanni A; Levi, Filippo; Calonico, Davide

    2016-01-01

    We report the absolute frequency measurement of the unperturbed transition 1S0 - 3P0 at 578 nm in 171Yb realized in an optical lattice frequency standard. The absolute frequency is measured 518 295 836 590 863.55(28) Hz relative to a cryogenic caesium fountain with a fractional uncertainty of 5.4x10-16 . This value is in agreement with the ytterbium frequency recommended as a secondary representation of the second in the International System of Units.

  14. Photoionization from the excited (3p, 3d, 4s, 4p) states of sodium

    Calculations are presented for the total cross section (σ) and the angular distribution of asymmetry parameter (β) for photoionization from initial excited (3p, 3d, 4s and 4p) states of sodium atom. Comparison of our results for σ and β is made with other available theoretical calculations and the experimental data. We also present results for the angular distributions in electron-Na+ elastic scattering at energies of k 0.5 and 1.0 a0. (author). 43 refs., 7 figs., 2 tabs

  15. Gene-centric Association Mapping of Chromosome 3p implicates MST1 in IBD pathogenesis

    Goyette, Philippe; Ng, Aylwin; Lefebvre, Céline; Brant, Steven R.; Cho, Judy H; Duerr, Richard H.; Silverberg, Mark S; Kent D. Taylor; Latiano, Anna; Aumais, Guy; Deslandres, Colette; Jobin, Gilles; Annese, Vito; Daly, Mark J.; Xavier, Ramnik J.

    2008-01-01

    Association mapping and candidate gene studies within IBD linkage regions, as well as genome-wide association studies in CD have led to the discovery of multiple risk genes, but these only explain a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and UC using a gene-centric association mapping approach. We identified twelve functional candidate genes by searching for literature co-citations with relevant k...

  16. Electron-phonon superconductivity in $A$Pt$_3$P compounds: from weak to strong coupling

    Subedi, Alaska; Ortenzi, Luciano; Boeri, Lilia

    2012-01-01

    We study the newly discovered Pt phosphides $A$Pt$_3$P ($A$=Sr, Ca, La) [ T. Takayama et al. Phys. Rev. Lett. 108, 237001 (2012)] using first-principles calculations and Migdal-Eliashberg theory. Given the remarkable agreement with the experiment, we exclude the charge-density wave scenario proposed by previous first-principles calculations, and give conclusive answers concerning the superconducting state in these materials. The pairing increases from La to Ca and Sr due to changes in the ele...

  17. sup 3 P sub 0 study of meson decays in a chiral quark model

    Bonnaz, R; Silvestre-Brac, B; Fernández, F; Valcarce, A

    2001-01-01

    The strong decays of a meson into two mesons are studied in the framework of the sup 3 P sub 0 model. The meson wave functions are determined by means of a realistic chiral quark model constructed in the baryon sector and comparison is made with a traditional potential of 'Coulomb + linear' type. Two different forms for the creation vertex are analyzed. A momentum dependent vertex is proved to be definitively superior. The chiral quark model provides an overall good description of all known transitions and gives results of roughly the same quality as those obtained from phenomenological quark-antiquark potentials.

  18. Diagnostic value of solitary pulmonary nodules using 99Tm-3P4-RGD2 scintigraphy

    Objective: To investigate the value of 99Tcm-HYNIC-(poly-(ethylene glycol), PEG)4-E (PEG4-c(RGDfK))2 (99Tcm-3P4-RGD2) SPECT imaging in the diagnosis of SPN by visual and semiquantitative analysis.Methods Twenty-one patients (13 men, 8 women; age range 37-77 (58±11) years) with SPN observed on CT were analyzed prospectively. All patients underwent SPECT imaging after administration of 99Tcm-3P4-RGD2 with a dose of (939 ± 118) MBq. The gold standard was based on the histopathological diagnosis of the surgical samples from all recruited patients. The diagnostic performance of CT, SPECT visual and semiquantitative analysis was compared and analyzed with ROC curves. Immunohistochemistry was performed in part of the samples to obtain the information of integrin αvβ3 expression. Informed consent was obtained from all patients. Application of a new radiopharmaceutical was permitted and approved by the local independent Ethics Committee and the Institutional Review Board of the China-Japan Union Hospital. One-way analysis of variance,two-sample t test were used with SPSS 13.0. Results: Among the 21 SPN patients, 15 cases (71%) were diagnosed as malignant, and the other 6 (29%) were benign. T/NT ratio in malignant SPN was higher than that in benign SPN (1.87 ± 0.39 vs 1.41 ± 0.65), but with no statistical significance (t=2.01, P>0.05). The sensitivities for CT, SPECT visual and semiquantitative analysis were 80% (12/15), 100% (15/15) and 100% (15/15) respectively,and the specificity were all 4/6. The AUC was 0.811 (95% CI 58%-95%) for CT, 0.833 (95% CI 61%-96%) for SPECT and 0.844 (95% CI 62%-96%) for T/NT ratios, which showed no statistical significance (F=0.83, P>0.05). Immunohistochemistry confirmed αvβ3 expression in both the malignant and benign nodules which had uptake of 99Tcm-3P4-RGD2 in SPECT imaging. Conclusion: SPECT visual and semiquantitative analysis with 99Tcm-3P4-RGD2 appears to have high sensitivity and consistency in diagnosis of SPN. (authors)

  19. Quantum chaos in ultracold collisions between Yb($^1$S$_0$) and Yb($^3$P$_2$)

    Green, Dermot G; Frye, Matthew D; Morita, Masato; Hutson, Jeremy M

    2015-01-01

    We calculate and analyze Feshbach resonance spectra for ultracold Yb($^1$S$_0$) + Yb($^3$P$_2$) collisions as a function of an interatomic potential scaling factor $\\lambda$ and external magnetic field. We show that, at zero field, the resonances are distributed randomly in $\\lambda$, but that signatures of quantum chaos emerge as a field is applied. The random zero-field distribution arises from superposition of structured spectra associated with individual total angular momenta. In addition, we show that the resonances in magnetic field in the experimentally accessible range 400 to 2000~G are chaotically distributed, with strong level repulsion that is characteristic of quantum chaos.

  20. Pulsar Spin-Down by 3P2 Superfluid Neutron with Field Decay

    LUO Xin-Lian; PENG Qiu-He; CHOU Chih-Kang

    2003-01-01

    To describe pulsar spin-down, we present a simple combined torque model that takes into account both the standard magnetic dipole radiation and the electromagnetic radiation from the 3P2 superSuid vortex neutrons inside neutron star. Using an ordinary exponential model for the magnetic field decay, we derive an analytical formulae for pulsar evolution tracks. The pulsar evolution on the P-P diagram is quite different from that of the standard magnetic dipole radiation model, especially when the supernuid torque or Geld decay becomes dominant.

  1. MiR-519d-3p suppresses invasion and migration of trophoblast cells via targeting MMP-2.

    Jie Ding

    Full Text Available Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military Medical University and complied strictly with national ethical guidelines. Preeclampsia (PE is a specific clinical disorder characterized by gestational hypertension and proteinuria and is a leading cause of maternal and perinatal mortality worldwide. The miR-519d-3p is upregulated in the maternal plasma of patients with PE which indicates a possible association between this microRNA and the pathogenesis of PE. No studies to date have addressed the effect of miR-519d-3p on the invasion and migration of trophoblast cells. In our study, we found that miR-519d-3p expression was elevated in placental samples from patients with PE. In vitro, overexpression of miR-519d-3p significantly inhibited trophoblast cell migration and invasion, whereas transfection of a miR-519d-3p inhibitor enhanced trophoblast cell migration and invasion. Luciferase assays confirmed that matrix metalloproteinase-2 (MMP-2 is a direct target of miR-519d-3p. Quantitative real-time PCR and western blot assays showed that overexpression of miR-519d-3p downregulated MMP-2 mRNA and protein expression. Knockdown of MMP-2 using a siRNA attenuated the increased trophoblast migration and invasion promoted by the miR-519d-3p inhibitor. In placentas from patients with PE or normal pregnancies, a negative correlation between the expression of MMP-2 and miR-519d-3p was observed using the Pearson correlation and linear regression analysis. Our present findings suggest that upregulation of miR-519d-3p may contribute to the development of PE by inhibiting trophoblast cell migration and invasion via targeting MMP-2; miR-519d-3p may represent a potential predictive and therapeutic target for PE.

  2. A New Case of an Extremely Rare 3p21.31 Interstitial Deletion.

    Lovrecic, Luca; Bertok, Sara; Žerjav Tanšek, Mojca

    2016-05-01

    Interstitial 3p21.31 deletions have been very rarely reported. We describe a 7-year-old boy with global developmental delay, specific facial characteristics, hydronephrosis, and hypothyreosis with a de novo deletion of 3p21.31, encompassing 29 OMIM genes. Despite the wide use of microarrays, no similar case has been reported in the literature so far. Five overlapping cases are deposited in the DECIPHER database, 2 of which have significant overlapping chromosomal aberrations. They both share some phenotypic characteristics with our case, e.g. developmental delay, intellectual disability and facial dysmorphism (arched eyebrows, hypertelorism, low-set ears, and a large nose tip). In addition, loss-of-function mutations in the SETD2 gene (OMIM 612778) of the deleted region have been described in 3 patients, presenting with some similar clinical features, namely overgrowth, intellectual disability, speech delay, hypotonia, autism, and epilepsy. Therefore, SETD2 may explain part of the phenotype in our case. We focused on 3 other genes in the deleted region, based on their known functions, namely CSPG5 (OMIM 606775), PTH1R (OMIM 168468) and SMARCC1 (OMIM 601732), and assessed their potentially important role in describing the patient's phenotype. Additional cases with haploinsufficiency of this region are needed to elucidate further genotype-phenotype correlations. PMID:27385966

  3. Optical potentials for Ne*(3P2,0)-Ar, N2 interactions

    Baudon, J.; Feron, P.; Miniatura, C.; Perales, F.; Reinhardt, J.; Robert, J.; Haberland, H.; Brunetti, B.; Vecchiocattivi, F.

    1991-08-01

    The differential elastic cross sections for Ne*(3P2,0)-Ar and Ne*(3P2,0)-N2 collisions have been measured in crossed beam experiments at 0.064 and 0.318 and at 0.071 and 0.295 eV, collision energies, respectively. These results have been analyzed simultaneously with integral cross sections and total ionization cross sections already available and optical spherical potentials for these two systems have been obtained. These potentials appear to be rather accurate in the distance range from 2.5 to ˜9 and from 3.0 to ˜9 Å for Ne*-Ar and Ne*-N2, respectively. The well depths and equilibrium distances are 5.12 meV and 4.9 Å for Ne*-Ar and 3.56 meV and 5.40 Å for Ne*-N2. The short-range repulsion in both cases exhibits a change in slope which can be correlated with the influence, for the interaction at shorter distances, of the Ne+ core of the metastable atom, which becomes less effective when the intermolecular distance increases. The optical potentials proposed here are given in analytical form suitable for the calculation of dynamical observables of these systems.

  4. Controlling the $2p$ Hole Alignment in Neon via the $2s$-$3p$ Fano Resonance

    Heinrich-Josties, Elisabeth; Santra, Robin

    2014-01-01

    We study the state-resolved production of neon ion after resonant photoionization of Ne via the $2s$-$3p$ Fano resonance. We find that by tuning the photon energy across the Fano resonance a surprisingly high control over the alignment of the final $2p$ hole along the polarization direction can be achieved. In this way hole alignments can be created that are otherwise very hard to achieve. The mechanism responsible for this hole alignment is the destructive interference of the direct and indirect (via the autoionizing $2s^{-1}3p$ state) ionization pathways of $2p$. By changing the photon energy the strength of the interference varies and $2p$-hole alignments with ratios up to 19:1 between $2p_0$ and $2p_{\\pm 1}$ holes can be created: an effect normally only encountered in tunnel ionization using strong-field IR pulses. Including spin-orbit interaction does not change the qualitative feature and leads only to a reduction in the alignment by $2/3$. Our study is based on a time-dependent configuration-interactio...

  5. A Mixed-Valent Molybdenum Monophosphate with a Layer Structure: KMo 3P 2O 14

    Guesdon, A.; Borel, M. M.; Leclaire, A.; Grandin, A.; Raveau, B.

    1994-03-01

    A new mixed-valent molybdenum monophosphate with a layer structure KMo 3P 2O 14 has been isolated. It crystallizes in the space group P2 1/ m with a = 8.599(2) Å, b = 6.392(2) Å, c = 10.602(1) Å, and β = 111.65(2)°. The layers [Mo 3P 2O 14] ∞ are parallel to (100) and consist of [MoPO 8] ∞ chains running along limitb→ , in which one MoO 6 octahedron alternates with one PO 4 tetrahedron. In fact, four [MoPO 8] ∞ chains share the corners of their polyhedra and the edges of their octahedra, forming [Mo 4P 4O 24] ∞ columns which are linked through MoO 5 bipyramids along limitc→. The K + ions interleaved between these layers are surrounded by eight oxygens, forming bicapped trigonal prisms KO 8. Besides the unusual trigonal bipyramids MoO 5, this structure is also characterized by a tendency to the localization of the electrons, since one octahedral site is occupied by Mo(V), whereas the other octahedral site and the trigonal bipyramid are occupied by Mo(VI). The similarity of this structure with pure octahedral layer structures suggests the possibility of generating various derivatives, and of ion exchange properties.

  6. CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF YEAST ARTIFICIAL CHROMOSOMES CONTAINING HUMAN 3P13-P21-SPECIFIC SEQUENCE-TAGGED SITES

    MICHAELIS, SC; BARDENHEUER, W; LUX, A; SCHRAMM, A; GOCKEL, A; SIEBERT, R; WILLERS, C; SCHMIDTKE, K; TODT, B; VANDERHOUT, AH; BUYS, CHCM; HEPPELLPARTON, AC; RABBITTS, PH; UNGAR, S; SMITH, D; LEPASLIER, D; COHEN, D; OPALKA, B; SCHUTTE, J

    1995-01-01

    Human chromosomal region 3p12-p23 is proposed to harbor at least three tumor suppressor genes involved in the development of lung cancer, renal cell carcinoma, and other neoplasias. In order to identify one of these genes we defined sequence tagged sites (STSs) specific for 3p13-p24.2 by analyzing a

  7. Research of Interaction Between Zn Based Solders and Cu, Al Substrates

    Prach Michal; Kostolný Igor; Koleňák Roman

    2014-01-01

    The paper deals with the study of interaction between Cu, Al substrates (purity 5N) and ZnAl4, ZnAg6Al6 zinc solders for higher application temperatures. Soldering was performed with power ultrasound in the air without flux application at temperature 420 °C. Acting time of ultrasonic vibration was 3 s and ultrasound frequency was 40 kHz. Soldered joints were assessed by optical light microscopy and EDX microanalysis. Intermetallic layers (IM) CuZn4 and Cu5Zn8 were formed at the Cu/ZnAl4 bound...

  8. Interaction between 4p photoionization and 3p resonant excitation channels of krypton

    Complete text of publication follows. The angular distribution of Kr 4p photoelectrons was measured employing a linearly polarized photon beam at energies from 205 eV to 230 eV. In this range the Kr 3p→ns/md (n,m=4,5,6, etc.) resonances can be excited. The experimental anisotropy parameters (β, γ and δ) were determined for the Kr 4p shell and its fine structure components. The measurement was carried out at beamline BW3 of the DORIS III synchrotron light source at HASYLAB (Hamburg, Germany). The ESA-22D electrostatic electron spectrometer was used to analyze the emitted electrons. The spectrometer consists of a spherical and a cylindrical mirror analyzer. The spherical mirror focuses the electrons from the scattering plane to the entrance slit of the cylindrical analyzer performing the energy analysis of the electrons. (For detailed description of an ESA- 22-type electron spectrometer see Ref. [1].) The measured dipole anisotropy parameters ? of Kr 4p photoelectrons are shown in Fig. 1 as a function of photon energy. Resonance-like structure can be seen in the photon energy dependence of the dipole parameters. This structure indicates that the channel interactions are important between the 3p resonant excitation-autoionization and 4p direct photoionization processes in krypton. The natural line width of the 3p photoelectron peaks was determined from the measured spectra and it is about 0.8 eV while the experimental width of the resonance near 220 eV photon energy (3p1/2-1→5s resonant excitation) is approximately 2 eV in Fig. 1. This broadening can be explained with the strong interference between the ionization and excitation channels. As before, we conclude that the angular distribution of photoelectrons is strongly influenced by the excitation processes. Acknowledgements. The authors wish to thank the DORIS III staff for providing excellent working conditions. This work was supported by the NKTH-OTKA (Grant No. K67719), and by the European Community

  9. Unified interpretation of Hund's first and second rules for 2p and 3p atoms.

    Oyamada, Takayuki; Hongo, Kenta; Kawazoe, Yoshiyuki; Yasuhara, Hiroshi

    2010-10-28

    A unified interpretation of Hund's first and second rules for 2p (C, N, O) and 3p (Si, P, S) atoms is given by Hartree-Fock (HF) and multiconfiguration Hartree-Fock (MCHF) methods. Both methods exactly satisfy the virial theorem, in principle, which enables one to analyze individual components of the total energy E(=T+V(en)+V(ee)), where T, V(en), and V(ee) are the kinetic, the electron-nucleus attraction, and the electron-electron repulsion energies, respectively. The correct interpretation for each of the two rules can only be achieved under the condition of the virial theorem 2T+V=0 by investigating how V(en) and V(ee) interplay to attain the lower total potential energy V(=V(en)+V(ee)). The stabilization of the more stable states for all the 2p and 3p atoms is ascribed to a greater V(en) that is caused by contraction of the valence orbitals accompanied with slight expansion of the core orbitals. The contraction of the valence orbitals for the two rules is a consequence of reducing the Hartree screening of the nucleus at short interelectronic distances. The reduced screening in the first rule is due to a greater amount of Fermi hole contributions in the state with the highest total spin-angular momentum S. The reduced screening in the second rule is due to the fact that two valence electrons are more likely to be on opposite sides of the nucleus in the state with the highest total orbital-angular momentum L. For each of the two rules, the inclusion of correlation does not qualitatively change the HF interpretation, but HF overestimates the energy difference ∣ΔE∣ between two levels being compared. The magnitude of the correlation energy is significantly larger for the lower L states than for the higher L states since two valence electrons in the lower L states are less likely to be on opposite sides of the nucleus. The MCHF evaluation of ∣ΔE∣ is in excellent agreement with experiment. The present HF and MCHF calculations demonstrate the above statements

  10. Study of Upsilon(3S,2S) -> eta Upsilon(1S) and Upsilon(3S,2S) -> pi+pi- Upsilon(1S) hadronic trasitions

    The BABAR Collaboration; Lees, J. P.; others

    2011-01-01

    We study the Upsilon(3S,2S)->eta Upsilon(1S) and Upsilon(3S,2S)->pi+pi- Upsilon(1S) transitions with 122 million Upsilon(3S) and 100 million Upsilon(2S) mesons collected by the BaBar detector at the PEP-II asymmetric energy e+e- collider. We measure B[Upsilon(2S)->eta Upsilon(1S)]=(2.39+/-0.31(stat.)+/-0.14(syst.))10^-4 and Gamma[Upsilon(2S)->eta Upsilon(1S)]/Gamma[Upsilon(2S)-> pi+pi- Upsilon(1S)]=(1.35+/-0.17(stat.)+/-0.08(syst.))10^-3. We find no evidence for Upsilon(3S)->eta Upsilon(1S) a...

  11. Search For the Lepton-Flavor Violating Decays Y(3S)->e tau and Y(3S)->mu tau

    Aubert, B.

    2008-12-11

    Charged lepton-flavor violating processes are extremely rare in the Standard Model, but they are predicted to occur in several beyond-the-Standard Model theories, including Supersymmetry or models with leptoquarks or compositeness. We present a search for such processes in a sample of 117 x 10{sup 6} {Upsilon}(3S) decays recorded with the BABAR detector. We place upper limits on the branching fractions BF({Upsilon}(3S) {yields} e{sup {+-}}{tau}{sup {-+}}) < 5.0 x 10{sup -6} and BF({Upsilon}(3S) {yields} {mu}{sup {+-}}{tau}{sup {-+}}) < 4.1 x 10{sup -6} at 90% confidence level. These results are used to place lower limits on the mass scale of beyond-the-Standard Model physics contributing to lepton-flavor violating decays of the {Upsilon}(3S).

  12. The spin-spin mixing of 1s3s3S1 and 1s3d3D1 states in the helium isoelectronic sequence

    Both relativistic and nonrelativistic analytical calculations of the off-diagonal matrix elements between excited vertical stroke 1s3s 3S1> and vertical stroke 1s3d 3D1> states of He-like atoms have been performed, taking into account the spin-spin interaction of the first order of perturbation theory. The considered values of nuclear charge Z range from Z = 2 to Z = 100. The nonrelativistic results for neutral helium agree well with earlier numerical estimates. The relativistic approach of evaluation of the off-diagonal matrix elements of He-like multicharged ions is analyzed in some details, using the hydrogen-like approximation for the basis wave functions. A precise evaluation of the one-photon exchange correction to the vertical stroke 1s3s 3S1> and vertical stroke 1s3d 3D1> energies is made. (orig.)

  13. MicroRNA-490-3p inhibits proliferation of A549 lung cancer cells by targeting CCND1

    Highlights: • We examined the level of miR-490-3p in A549 lung cancer cells compared with normal bronchial epithelial cell line. • We are the first to show the function of miR-490-3p in A549 lung cancer cells. • We demonstrate CCND1 may be one of the targets of miR-490-3p. - Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate the translation of messenger RNAs by binding their 3′-untranslated region (3′UTR). In this study, we found that miR-490-3p is significantly down-regulated in A549 lung cancer cells compared with the normal bronchial epithelial cell line. To better characterize the role of miR-490-3p in A549 cells, we performed a gain-of-function analysis by transfecting the A549 cells with chemically synthesized miR-490-3P mimics. Overexpression of miR-490-3P evidently inhibits cell proliferation via G1-phase arrest. We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1, which plays a key role in G1/S phase transition. In addition, the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3′UTR. These findings indicated miR-490-3P could be a potential suppressor of cellular proliferation

  14. Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae.

    Soracom Chardwiriyapreecha

    Full Text Available In Saccharomyces cerevisiae, Avt3p and Avt4p mediate the extrusion of several amino acids from the vacuolar lumen into the cytosol. SpAvt3p of Schizosaccharomyces pombe, a homologue of these vacuolar amino acid transporters, has been indicated to be involved in spore formation. In this study, we confirmed that GFP-SpAvt3p localized to the vacuolar membrane in S. pombe. The amounts of various amino acids increased significantly in the vacuolar pool of avt3Δ cells, but decreased in that of avt3+-overexpressing avt3Δ cells. These results suggest that SpAvt3p participates in the vacuolar compartmentalization of amino acids in S. pombe. To examine the export activity of SpAvt3p, we expressed the avt3+ gene in S. cerevisiae cells. We found that the heterologously overproduced GFP-SpAvt3p localized to the vacuolar membrane in S. cerevisiae. Using the vacuolar membrane vesicles isolated from avt3+-overexpressing S. cerevisiae cells, we detected the export activities of alanine and tyrosine in an ATP-dependent manner. These activities were inhibited by the addition of a V-ATPase inhibitor, concanamycin A, thereby suggesting that the activity of SpAvt3p is dependent on a proton electrochemical gradient generated by the action of V-ATPase. In addition, the amounts of various amino acids in the vacuolar pools of S. cerevisiae cells were decreased by the overproduction of SpAvt3p, which indicated that SpAvt3p was functional in S. cerevisiae cells. Thus, SpAvt3p is a vacuolar transporter that is involved in the export of amino acids from S. pombe vacuoles.

  15. Spin structure of binary processes in the 3P0 model of coloured tube

    The binary processes 0+1/2 →0+1/2 (π-p → π0n, π-p → ηn) are considered in the coloured tube model. It is shown that the relations of residues of the amplitude M0+iσ-vectorn-vectorq/2q0M1 and their q2-dependence at the secondary Regge pole exchange is determined by the wave function of a gg-bar pair which appears in the 3P0 state at disruption of a coloured tube. The account of the Thomas interaction gives a small contribution into matrix elements logarithmically decreasing with energy. The model, accounting for absorption, agrees semiquantitatively with experimental data

  16. Product lambda-doublet ratios for the O(3P) + D2 reaction: A mechanistic imprint

    Jambrina, P G; Aldegunde, J; Brouard, M; Aoiz, F J

    2016-01-01

    In the last decade, the development of theoretical methods have allowed chemists to reproduce and explain almost all of the experimental data associated with elementary atom plus diatom collisions. However, there are still a few examples where theory cannot account yet for experimental results. This is the case for the preferential population of one of the $\\Lambda$-doublet states produced by chemical reactions. In particular, recent measurements of the OD($^2\\Pi$) product of the O($^3$P) + D$_2$ reaction have shown a clear preference for the $\\Pi(A')$ $\\Lambda$-doublet states, in apparent contradiction with {\\em ab initio} calculations, which predict a larger reactivity on the $A"$ potential energy surface. Here we present a method to calculate the $\\Lambda$-doublet ratio when concurrent potential energy surfaces participate in the reaction. It accounts for the experimental $\\Lambda$-doublet populations via explicit consideration of the stereodynamics of the process. Furthermore, our results demonstrate that...

  17. Lanthanide refractory semiconductors based on the Th/sub 3/P/sub 4/ structure

    The phase relationships and the important structural, electrical and thermal properties of the R/sub 3/X/sub 4/-R/sub 2/X/sub 3/ (where R = lanthanides and X = S, Se and Te) phases having the Th/sub 3/P/sub 4/-type structure are reviewed. The room temperature electrical resistivity and Seebeck coefficient of these materials are independent of R and only slightly dependent on X, but critically dependent on the X:R ratio. The long term stability of these phases is also reviewed. Although these materials have good thermoelectric properties there are some problems which need to be solved before these phases can be utilized in thermoelectric devices. These problems include long term stability, higher than desirable thermal conductivities, and low electron mobilities

  18. Mechanisms and Kinetics of Radical Reaction of O(1D,3P) + HCN System

    HUANG Yu-Cheng; DU Jin-Yan; JU Xue-Hai; YE Shi-Yong; ZHOU Tao

    2008-01-01

    The reaction of HCN with O(1D, 3P) radical has been investigated by density functional theory (DFT) and ab initio methods. The stationary points on the reaction paths(reactants, intermediates and products) were optimized at the (U)B3LYP/aug-cc-pVTZ level.Single-point calculations were performed at the (U)QCISD(T)/aug-cc-pVTZ level for the optimized structures and all the total energies were corrected by zero-point energy. It is shown that there exist three competing mechanisms of oxygen attacking nitrogen O→N, oxygen attacking carbon O→C and oxygen attacking hydrogen O→H. The rate constants were obtained via Eyring transition-state theory in the temperature range of 600~2000 K. The linear relationship between lnk and 1/T was presented. The results show that path 1 is the main reaction channel and the product of NCO + H is predominant.

  19. High strength Al–Al2O3p composites: Optimization of extrusion parameters

    Luan, B.F.; Hansen, Niels; Godfrey, A.;

    2011-01-01

    Composite aluminium alloys reinforced with Al2O3p particles have been produced by squeeze casting followed by hot extrusion and a precipitation hardening treatment. Good mechanical properties can be achieved, and in this paper we describe an optimization of the key processing parameters. The...... investigation of their mechanical properties and microstructure, as well as on the surface quality of the extruded samples. The evaluation shows that material with good strength, though with limited ductility, can be reliably obtained using a production route of squeeze casting, followed by hot extrusion and a...... precipitation hardening treatment. For the extrusion step optimized processing parameters have been determined as: (i) extrusion temperature=500°C–560°C; (ii) extrusion rate=5mm/s; (iii) extrusion ratio=10:1....

  20. Electron impact excitation of 2p and 3p states of hydrogen at intermediate energies

    A coupled-channel-optical (CCO) calculation with 9 and 12 atomic states supplemented with the continuum optical potentials for the stronger coupling channels has been performed for the electron impact excitation of hydrogen. The calculated n = 2 and n = 3 differential cross sections and the reduced Stokes parameters are comparable with the state-of-the art calculations. There is closer agreement between the present calculations and the experimental measurements for the reduced Stokes parameters P-bar1 and P-bar3 in the n = 2p excitation at 54.4 eV. The present CCO calculations also display good accord with the limited experimental data for the reduced Stokes parameters in the n = 3p excitation. (authors)

  1. Precision Hyperfine Structure of 2;^3P State of ^3He with External Magnetic

    Wu, Qixue; Drake, G. W. F.

    2007-06-01

    The theory of the Zeeman effect can be used to extrapolate precise measurements for the fine structure or the hyperfine structure to zero-field strength. In the present work, the hyperfine structure of 2;^3P state of ^3He with external magnetic fields is precisely calculated. The values of the fields for 32 crossings and five anticrossings of the magnetic sublevels are theoretically predicted for magnetic field strengths up to 1 Tesla. The results are compared with experimental work. We include the linear terms, diamagnetic terms, and the 2̂ relativistic correction terms in the Zeeman Hamiltonian. All related matrix elements are calculated with high accuracy by the use of double basis set Hylleraas type variational wave functions[1,2].[1] Z. -C. Yan and G.W.F. Drake, Phys. Rev. A 50, R1980 (1994).[2] Q. Wu and G.W.F. Drake, J. Phys. B 40, 393 (2007).

  2. Microstructure, thermal, and mechanical properties of nanostructured Cu-9.5Ni-4.0Sn-7.5P

    Li, J.; Wang, T. M.

    1995-04-01

    Nanostructured Cu-9.5Ni-4.0Sn-7.5P samples represent a polycrystal microstructure of nanometer-sized α-Cu and Cu3P crystallites for crystallite sizes less than 20 nm and of nanometer-sized α-Cu, Cu3P, and Ni2P crystallites for crystallite sizes greater than 20 nm. The specific heat values between 300 K and 400 K for the nanostructured sample with crystallite size of 10 nm are about 20% higher than for the amorphous sample and about 40% higher than for the coarse-grained sample. The hardness of the nanostructured sample with crystallite size of 10 nm is 30% higher than that of the amorphous sample and 110% higher than that of the coarse-grained sample. The variation in hardness with the crystallite size for the nanostructured samples follows the Hall-Petch relationship.

  3. Thermochemical process for recovering Cu from CuO or CuO.sub.2

    Richardson, deceased, Donald M.; Bamberger, Carlos E.

    1981-01-01

    A process for producing hydrogen comprises the step of reacting metallic Cu with Ba(OH).sub.2 in the presence of steam to produce hydrogen and BaCu.sub.2 O.sub.2. The BaCu.sub.2 O.sub.2 is reacted with H.sub.2 O to form Cu.sub.2 O and a Ba(OH).sub.2 product for recycle to the initial reaction step. Cu can be obtained from the Cu.sub.2 O product by several methods. In one embodiment the Cu.sub.2 O is reacted with HF solution to provide CuF.sub.2 and Cu. The CuF.sub.2 is reacted with H.sub.2 O to provide CuO and HF. CuO is decomposed to Cu.sub.2 O and O.sub.2. The HF, Cu and Cu.sub.2 O are recycled. In another embodiment the Cu.sub.2 O is reacted with aqueous H.sub.2 SO.sub.4 solution to provide CuSO.sub.4 solution and Cu. The CuSO.sub.4 is decomposed to CuO and SO.sub.3. The CuO is decomposed to form Cu.sub.2 O and O.sub.2. The SO.sub.3 is dissolved to form H.sub.2 SO.sub.4. H.sub.2 SO.sub.4, Cu and Cu.sub.2 O are recycled. In another embodiment Cu.sub.2 O is decomposed electrolytically to Cu and O.sub.2. In another aspect of the invention, Cu is recovered from CuO by the steps of decomposing CuO to Cu.sub.2 O and O.sub.2, reacting the Cu.sub.2 O with aqueous HF solution to produce Cu and CuF.sub.2, reacting the CuF.sub.2 with H.sub.2 O to form CuO and HF, and recycling the CuO and HF to previous reaction steps.

  4. Cu(I)/Cu(II) templated functional pseudorotaxanes and rotaxanes

    Subrata Saha; Pradyut Ghosh

    2012-11-01

    Threaded complexes like pseudorotaxanes, rotaxanes based on Cu(I)/Cu(II) ions have shown to be promising for the construction of mechanically interlocked molecular-level architectures. In this short review, we focus on the synthetic strategies developed to construct pseudorotaxanes and rotaxanes using Cu(I)/Cu(II) ions as template. Further, brief discussions on chemical and mechanical properties associated with some of the selected to Cu(I)/Cu(II) based pseudorotaxanes and rotaxanes are presented.

  5. Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.

    Gu, Nan; You, Lianghui; Shi, Chunmei; Yang, Lei; Pang, Lingxia; Cui, Xianwei; Ji, Chenbo; Zheng, Wen; Guo, Xirong

    2016-08-01

    Obesity is associated with a notable risk for disease, including risk of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension. Adipose tissue modulates the metabolism by releasing free fatty acids (FFAs) and adipokines, including leptin, resistin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL‑6). Altered secretion patterns of FFAs and adipokines have been demonstrated to result in obesity‑associated insulin resistance (IR) and inflammatory responses. MicroRNA-199a-3p (miR)-199a-3p expression is significantly induced in differentiated human adipose-derived mesenchymal stem cells and indicates the association with T2DM. However, the association between miR-199a-3p levels in adipocytes and obesity‑associated IR, as well as inflammatory responses remains to be elucidated. The present study observed an elevation of miR‑199a‑3p expression level in mature human adipocytes (visceral) compared with pre-adipocytes. In addition, miR‑199a‑3p expression was higher in visceral adipose deposits from obese subjects. FFA, TNF-α, IL‑6 and leptin significantly induced miR‑199a‑3p expression in mature human adipocytes, while resistin had the opposite effect. miR‑199a‑3p may represent a factor in the modulation of obesity‑associated IR and inflammatory responses. PMID:27279151

  6. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200.

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  7. A controllable synthetic route to Cu, Cu2O, and CuO nanotubes and nanorods.

    Cao, Minhua; Hu, Changwen; Wang, Yonghui; Guo, Yihang; Guo, Caixin; Wang, Enbo

    2003-08-01

    Reducing Cu(OH)4(2-) with hydrazine hydrate and glucose in the presence of a structure-directing surfactant at room temperature gave Cu and Cu2O nanotubes/nanorods, respectively, whereas facile hydrothermal treatment of Cu(OH)4(2-) precursor resulted in CuO nanotubes/nanorods. PMID:12932015

  8. MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes.

    Kang, Liang; Yang, Cao; Song, Yu; Liu, Wei; Wang, Kun; Li, Shuai; Zhang, Yukun

    2016-09-01

    Osteoarthritis (OA) is a common chronic degenerative joint disease. Progressive destruction of the integrity of articular cartilage is an important pathological feature, but treatment options that reverse this damage have not been developed. According to recent studies, microRNAs have important regulatory roles in the initiation and progression of OA. In the current study, the biological effects of miR-23a-3p and its expression in OA tissues were examined. We found that miR-23a-3p expression was obviously higher and SMAD3 expression was significantly lower in OA cartilage than in normal tissues. The hypomethylation status of CpG islands in the promoter region of miR-23a-3p was confirmed by methylation-specific polymerase chain reaction in OA cartilage tissues. Furthermore, a bioinformatics analysis and luciferase reporter assay identified SMAD3 as a target gene of miR-23a-3p and SMAD3 expression at both the protein and mRNA levels was inhibited by miR-23a-3p. A functional analysis demonstrated that miR-23a-3p overexpression suppresses type II collagen and aggrecan expression, while miR-23a-3p inhibition had the opposite effects. Small interfering RNA-mediated knockdown of SMAD3 reversed the effects of the miR-23a-3p inhibitor on the expression of type II collagen and aggrecan. Our results suggested that miR-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment. PMID:27318087

  9. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells

  10. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping, E-mail: bieping2010@163.com

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  11. Genomic characterization of uncommon human G3P[6] rotavirus strains causing diarrhea in children in Italy in 2009.

    Ianiro, Giovanni; Delogu, Roberto; Fiore, Lucia; Ruggeri, Franco M

    2015-07-01

    Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis in young children, causing up to 450,000 deaths worldwide, mostly in developing countries. Most of RVA human infections in developed countries are related to five major G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8]. During the surveillance activity of RotaNet-Italy, three uncommon G3P[6] RVA strains, designated as RVA/Human-wt/ITA/NA01/2009/G3P[6], RVA/Human-wt/ITA/NA06/2009/G3P[6], and RVA/Human-wt/ITA/NA19/2009/G3P[6], were identified in the stools of children with diarrhea hospitalized in Southern Italy in 2009. Samples NA01, NA06 and NA19 were characterized as genotype G3P[6]. To investigate the three strains further, partial sequencing of the eleven genomic segments was performed. RVA strains NA01, NA06 and NA19 were found to share the rare genotype constellation: G3-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2, which had not been reported previously in continental Italy. The phylogenetic analysis of the eleven genomic segments showed no evidence of zoonosis or inter-species reassortment at the origin of the Italian G3P[6] strains, indicating that they possessed DS-1-like genomic constellations similar to those detected previously in human cases in Africa and Europe. The analysis of the hypervariable regions of VP7 and VP4 (VP8*) revealed high amino acid identity between the Italian G3P[6] RVA strains involved in this study. PMID:25913157

  12. The system Cu-Rh-S at 900 degrees, 700 degrees, 540 degrees and 500 degrees C

    Karup-Møller, Sven; Makovicky, E.

    2007-01-01

    Phase relations in the dry condensed system Cu-Rh-S were determined at 900, 700, 540 and 500 degrees C. At 900 degrees C, the system contains digenite, four rhodium sulfides (Rh17S15, Rh3S4, Rh2S3 and RhS similar to 3), three ternary sulfides (CuRh2S4, CuxRhS3+x and a fibrous sulfide in the range...... Cu11.9Rh24.6S63.6 - Cu20.4Rh19.8S59.7), Cu-S sulfide melt, and Cu-Rh alloys. At 700 degrees C, the ternary association changes to CuRh2S4, CuRhS3, and CuRhS4. All these phases persist with little change at 540 degrees C. At 500 degrees C, CuS appears, and the number of phases is reduced; only CuRhS4...... persists as a ternary phase. Ranges of solid solution for Cu-Rh alloys drop drastically with temperature. The solubility of Cu in Rh sulfides increases moderately as temperature decreases from 900 degrees to 540 degrees C. The solubility of Rh in digenite and Cu-S melt is very limited at all temperatures....

  13. Hyperfine Quenching of the $4s4p ^{3}P_{0}$ Level in Zn-like Ions

    Marques, J P; Indelicato, Paul

    2007-01-01

    In this paper, we used the multiconfiguration Dirac-Fock method to compute with high precision the influence of the hyperfine interaction on the $[Ar]3d^{10} 4s4p ^3P_0$ level lifetime in Zn-like ions for stable and some quasi-stable isotopes of nonzero nuclear spin between Z=30 and Z=92. The influence of this interaction on the $[Ar]3d^{10} 4s4p ^3P_1 - [Ar]3d^{10} 4s4p ^3P_0$ separation energy is also calculated for the same ions.

  14. Energy-band alignment of II-VI/Zn3P2 heterojunctions from x-ray photoemission spectroscopy

    Watson, Graeme

    2013-01-01

    PUBLISHED The energy-band alignments for zb-ZnSe(001)/ a -Zn 3 P 2 (001), w-CdS(0001)/ a -Zn 3 P 2 (001), and w-ZnO(0001)/ a -Zn 3 P 2 (001) heterojunctions have been determined using high-resolution x-ray photoelectron spectroscopy via the Kraut method. Ab initio hybrid density functional theory calculations of the valence-band density of states were used to determine the energy differences between the core level and ...

  15. Wakefield Computations for the CLIC PETS using the Parallel Finite Element Time-Domain Code T3P

    Candel, A; Kabel, A.; Lee, L.; Li, Z.; Ng, C.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; /CERN

    2009-06-19

    In recent years, SLAC's Advanced Computations Department (ACD) has developed the high-performance parallel 3D electromagnetic time-domain code, T3P, for simulations of wakefields and transients in complex accelerator structures. T3P is based on advanced higher-order Finite Element methods on unstructured grids with quadratic surface approximation. Optimized for large-scale parallel processing on leadership supercomputing facilities, T3P allows simulations of realistic 3D structures with unprecedented accuracy, aiding the design of the next generation of accelerator facilities. Applications to the Compact Linear Collider (CLIC) Power Extraction and Transfer Structure (PETS) are presented.

  16. The standard molar Gibbs energy formation of Rb2ThO3(s)

    The standard molar Gibbs energy of formation of Rb2ThO3(s) has been determined using manometric technique. The equilibrium CO2(g) pressure over the three phase mixture: [Rb2ThO3(s)+ Rb2CO3(s)+ ThO2(s)] have been measured using an oil manometer in the temperature range 952 to 1113 K. The corresponding Gibbs energy expression as a function of temperature is given by: ΔfGom (Rb2ThO3, s,T) (kJ mol-l) ± 23 = ∼1691.4 + 0.2609 T(K). (author)

  17. Investigating Safety, Safeguards and Security (3S) Synergies to Support Infrastructure Development and Risk-Informed Methodologies for 3S by Design

    In 2008, Japan and other G8 countries pledged to support the Safeguards, Safety, and Security (3S) Initiative to raise awareness of 3S worldwide and to assist countries in setting up nuclear energy infrastructures that are essential cornerstones of a successful nuclear energy program. The goals of the 3S initiative are to ensure that countries already using nuclear energy or those planning to use nuclear energy are supported by strong national programs in safety, security, and safeguards not only for reliability and viability of the programs, but also to prove to the international audience that the programs are purely peaceful and that nuclear material is properly handled, accounted for, and protected. In support of this initiative, Japan Atomic Energy Agency (JAEA) has been conducting detailed analyses of the R and D programs and cultures of each of the 'S' areas to identify overlaps where synergism and efficiencies might be realized, to determine where there are gaps in the development of a mature 3S culture, and to coordinate efforts with other Japanese and international organizations. As an initial outcome of this study, incoming JAEA employees are being introduced to 3S as part of their induction training and the idea of a President's Award program is being evaluated. Furthermore, some overlaps in 3S missions might be exploited to share facility instrumentation as with Joint-Use-Equipment (JUE), in which cameras and radiation detectors, are shared by the State and IAEA. Lessons learned in these activities can be applied to developing more efficient and effective 3S infrastructures for incorporating into Safeguards by Design methodologies. They will also be useful in supporting human resources and technology development projects associated with Japan's planned nuclear security center for Asia, which was announced during the 2010 Nuclear Security Summit. In this presentation, a risk-informed approach regarding integration of 3S will be introduced. An initial

  18. Atomic layer deposition of ultrathin Cu2O and subsequent reduction to Cu studied by in situ x-ray photoelectron spectroscopy

    The growth of ultrathin (<5 nm) Ru-doped Cu2O films deposited on SiO2 by atomic layer deposition (ALD) and Cu films by subsequent reduction of the Cu2O using HCO2H or CO is reported. Ru-doped Cu2O has been deposited by a mixture of 16: 99 mol. % of [(nBu3P)2Cu(acac)] as Cu precursor and 17: 1 mol. % of [Ru(η5-C7H11)(η5-C5H4SiMe3)] as Ru precursor. The catalytic amount of Ru precursor was to support low temperature reduction of Cu2O to metallic Cu by formic acid (HCO2H) on arbitrary substrate. In situ x-ray photoelectron spectroscopy investigations of the Cu2O ALD film indicated nearly 1 at. % of carbon contamination and a phosphorous contamination below the detection limit after sputter cleaning. Systematic investigations of the reduction of Ru-doped Cu2O to metallic Cu by HCO2H or CO as reducing agents are described. Following the ALD of 3.0 nm Cu2O, the ultrathin films are reduced between 100 and 160 °C. The use of HCO2H at 110 °C enabled the reduction of around 90% Cu2O. HCO2H is found to be very effective in the removal of oxygen from Ru-doped Cu2O films with 2.5–4.7 nm thickness. In contrast, CO was effective for the removal of oxygen from the Cu2O films only below 3.0 nm at 145 °C. Root mean square surface roughness of 0.4 ± 0.1 nm was observed from atomic force microscopy (AFM) investigations after the ALD of Cu2O, followed by the subsequent reduction of 3.0 nm Cu2O using either HCO2H at 110 °C or CO at 145 °C on SiO2. Furthermore, ex situ low energy ion scattering and AFM investigations confirmed that the Cu2O film after ALD and Cu films after subsequent reduction was continuous on the SiO2 substrate

  19. Join the CERN ISEF special award winners | 16 June - 3 p.m.

    2016-01-01

    Come and join the CERN ISEF special award winners at their lightning talks session on 16 June at 3.00 p.m. in the main auditorium.   The 2016 Intel ISEF CERN special award winners on stage with the selection committee on 17 May 2016 in Phoenix, Arizona, USA. (Picture: Society for Science and the Public) Between 11 and 17 June 2016, the ten finalists of the Intel International Science and Engineering Fair (ISEF) who won the CERN Special Award, will visit CERN to partake in various educational lectures. ISEF is the world's largest international pre-college science competition, with approximately 1,700 high school students from more than 75 countries taking part. They will present their projects in short 5 minutes lightning talks' sessions at the main auditorium on Thursday 16 June at 3 p.m. The award winners would be also very happy to have a chance to interact and discuss with you af...

  20. (2p2)3P state of H- and the convergence of the CI series

    A sequence of increasingly accurate configuration interaction (CI) wave functions is used to discuss binding and the convergence of the CI series for the (2p2)3P state of H-. We get an upper bound energy E/sub u/=-0.1 253 547 166 a.u.(H), the lowest yet obtained, lying within an estimated 0.4 μhartree from the exact eigenvalue of Schroedinger's nonrelativistic equation. The angular energy limits define angular energy increments ΔE/sub l/ which follows the formula ΔE/sub l/approx. =0.18 (l+1/2)-7a.u. for l> or =4. Five or eighty per cent of binding is obtained with a three-term Psi=c1(2p)2+c2(2p')2+c3 (3d)2 depending on whether the 2p,2p', and 3d orbitals are energy optimized STO's or accurate natural orbitals, respectively

  1. Half-quantized Non-Abelian Vortices in Neutron $^3P_2$ Superfluids inside Magnetars

    Masuda, Kota

    2016-01-01

    We point out that half-quantized non-Abelian vortices exist as the minimum energy states in rotating neutron $^3P_2$ superfluids in the inner cores of magnetars with magnetic field greater than $3 \\times 10^{15}$ Gauss, while they do not in ordinary neutron stars with smaller magnetic fields. One integer vortex is split into two half-quantized vortices. The number of vortices is about $10^{19}$ and they are separated at about $\\mu$m in a vortex lattice for typical parameters, while the vortex core size is about 10-100 fm. They are non-Abelian vortices characterized by non-Abelian first homotopy group, and consequently when two vortices corresponding to non-commutative elements collide, a rung vortex must be created between them, implying the formation of an entangled vortex network inside the cores of magnetars. We find the spontaneous magnetization in the vortex core showing anti-ferromagnetism whose typical magnitude is about $10^{8-9}$ Gauss that is ten times larger than that of integer vortices, when exte...

  2. ACE3P Computations of Wakefield Coupling in the CLIC Two-Beam Accelerator

    Candel, Arno; Li, Z.; Ng, C.; Rawat, V.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; Grudiev, A.; Wuensch, W.; /CERN

    2010-10-27

    The Compact Linear Collider (CLIC) provides a path to a multi-TeV accelerator to explore the energy frontier of High Energy Physics. Its novel two-beam accelerator concept envisions rf power transfer to the accelerating structures from a separate high-current decelerator beam line consisting of power extraction and transfer structures (PETS). It is critical to numerically verify the fundamental and higher-order mode properties in and between the two beam lines with high accuracy and confidence. To solve these large-scale problems, SLAC's parallel finite element electromagnetic code suite ACE3P is employed. Using curvilinear conformal meshes and higher-order finite element vector basis functions, unprecedented accuracy and computational efficiency are achieved, enabling high-fidelity modeling of complex detuned structures such as the CLIC TD24 accelerating structure. In this paper, time-domain simulations of wakefield coupling effects in the combined system of PETS and the TD24 structures are presented. The results will help to identify potential issues and provide new insights on the design, leading to further improvements on the novel CLIC two-beam accelerator scheme.

  3. Utilising the `3P-model' to Characterise the Discipline of Didactics of Science

    Adúriz-Bravo, Agustín; Izquierdo-Aymerich, Mercè

    In our research within didactics of science, we have been exploring contributions of the so called cognitive models from contemporary philosophy of science. We have used these philosophical frameworks on different levels. As an outcome, we have formulated a model of didactics of science according to which this discipline adapts and transforms theoretical contributions from different scholarly fields. In this paper, we concentrate on this description of didactics of science, which we have called the 3P-model (i.e., philosophy + psychology + pedagogy). This model of the internal functioning of the discipline may be useful to make innovations in science curriculum design and re-conceptualise the role of science teachers as professionals. We see didactics of science as a set of interrelated activities, performed by different individuals, and ranging from theoretical production to practice of science education at school. We find the concept of technoscience suitable to account for this diversity of goals. According to this concept, scientific disciplines are identified both with generation of knowledge and with active intervention on the world. Within current didactics of science, we recognise several kinds of research, having goals more or less directed to practical intervention in science education.

  4. Precision frequency measurement of 1S0–3P1 intercombination lines of Sr isotopes

    We report on frequency measurement of the intercombination (5s2)1S0–(5s5p)3P1 transition of the four natural isotopes of strontium, including 88Sr (82.58%), 87Sr (7.0%), 86Sr (9.86%), and 84Sr (0.56%). A narrow-linewidth laser that is locked to an ultra-low expansion (ULE) optical cavity with a finesse of 12000 is evaluated at a linewidth of 200 Hz with a fractional frequency drift of 2.8×10−13 at an integration time of 1 s. The fluorescence collector and detector are specially designed, based on a thermal atomic beam. Using a double-pass acousto-optic modulator (AOM) combined with a fiber and laser power stabilization configuration to detune the laser frequency enables high signal-to-noise ratios and precision saturated spectra to be obtained for the six transition lines, which allows us to determine the transition frequency precisely. The optical frequency is measured using an optical frequency synthesizer referenced to an H maser. Both the statistical values and the final values, including the corrections and uncertainties, are derived for a comparison with the values given in other works. (paper)

  5. miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene.

    Meng, Fang; Qian, Liting; Lv, Lei; Ding, Bojin; Zhou, Gieping; Cheng, Xu; Niu, Sanqiang; Liang, Yu

    2016-04-01

    Chemoradiation therapy is an important component of the curative treatment for oesophageal carcinomas. These therapeutic effects are prevented in patients according to radioresistance and multi-drug resistance, and the cause of such resistance remains unclear. In this study, we identified the role of miR-193a-3p in modulating the radioresistance and chemoresistance of oesophageal cancer cells. We found that KYSE150 and KYSE410 cells could be characterized as relatively radiation-sensitive and radiation-resistant cells, respectively. Similarly, KYSE150 and KYSE410 cells were found to be chemosensitive and chemoresistant, respectively. Over-expression of miR-193a-3p increased the radioresistance and chemoresistance of oesophageal squamous cell carcinoma (ESCC) cells. In contrast, the down-regulation of miR-193a-3p decreased the radioresistance and chemoresistance of ESCC cells. In addition, miR-193a-3p inducing DNA damage has also been demonstrated through measuring the level of gamma-H2AX associated with miR-193a-3p. Moreover, a small interfering RNA(siRNA)-induced repression of the PSEN1 gene had an effect similar to that of miR-193a-3p up-regulation. The above processes also inhibited oesophageal cancer cells apoptosis. These findings suggest that miR-193a-3p contributes to the radiation and chemotherapy resistance of oesophageal carcinoma by down-regulating PSEN1. Thus, miR-193a-3p and PSEN1 might be potential biomarkers for chemoradiation resistant cancers. PMID:26743123

  6. Prm3p Is a Pheromone-induced Peripheral Nuclear Envelope Protein Required for Yeast Nuclear Fusion

    Shen, Shu; Tobery, Cynthia E.; Rose, Mark D.

    2009-01-01

    Nuclear membrane fusion is the last step in the mating pathway of the yeast Saccharomyces cerevisiae. We adapted a bioinformatics approach to identify putative pheromone-induced membrane proteins potentially required for nuclear membrane fusion. One protein, Prm3p, was found to be required for nuclear membrane fusion; disruption of PRM3 caused a strong bilateral defect, in which nuclear congression was completed but fusion did not occur. Prm3p was localized to the nuclear envelope in pheromon...

  7. Electron impact excitation out of the metastable levels of argon into the 3p54p J = 3 level

    We have measured the direct cross section for electron impact excitation out of the metastable 3p54s[3/2]20 level (1s5 in Paschen's notation) into the 3p54p[5/2]3 level (2p9) of argon from threshold to 800 eV. The direct cross section is 40 x 10-16 cm2 at 10 eV. (author)

  8. MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma.

    Deng, Danni; Wang, Lei; Chen, Yao; Li, Bowen; Xue, Lian; Shao, Naiyuan; Wang, Qiang; Xia, Xiwei; Yang, Yilin; Zhi, Feng

    2016-07-01

    The PIM1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and metabolism in various human cancers. MicroRNAs (miRNAs) are powerful post-transcriptional gene regulators that function through translational repression or transcript destabilization. Therefore, we aimed to identify whether a close relationship exists between PIM1 and miRNAs. PIM1 protein levels and mRNA levels were significantly upregulated in astrocytoma tissues, indicating the oncogenic role of PIM1 in astrocytoma. Further bioinformatics analysis indicated that miR-124-3p targeted the 3'-UTR of PIM1. We also observed an inverse correlation between the miR-124-3p levels and PIM1 protein or mRNA levels in astrocytoma samples. Next, we experimentally confirmed that miR-124-3p directly recognizes the 3'-UTR of the PIM1 transcript and regulates PIM1 expression at both the protein and mRNA levels. Furthermore, we examined the biological consequences of miR-124-3p targeting PIM1 in vitro. We showed that the repression of PIM1 in astrocytoma cancer cells by miR-124-3p suppressed proliferation, invasion, and aerobic glycolysis and promoted apoptosis. We observed that the restoration or inhibition of PIM1 activity resulted in effects that were similar to those induced by miR-124-3p inhibitors or mimics in cancer cells. Finally, overexpression of PIM1 rescued the inhibitory effects of miR-124-3p. In summary, these findings aid in understanding the tumor-suppressive role of miR-124-3p in astrocytoma pathogenesis through the inhibition of PIM1 translation. PMID:27088547

  9. First-principles study of electronic structure of CuSbS{sub 2} and CuSbSe{sub 2} photovoltaic semiconductors

    Maeda, T., E-mail: tmaeda@ad.ryukoku.ac.jp; Wada, T.

    2015-05-01

    We studied the features of CuSbS{sub 2} (CAS) and CuSbSe{sub 2} (CASe), two proposed photovoltaic compounds, and clarified their electronic structures by first-principles calculations and compared them to the chalcopyrite-type CuInSe{sub 2} results. For both CAS and CASe, the calculated enthalpies of formation of the chalcostibite phases were considerably lower than those of the chalcopyrite phases. Therefore, we considered that the chalcostibite phase is more stable for CAS and CASe. In their band structure calculated with the HSE06 hybrid functional, the valence band maxima of CAS and CASe were located at the Γ-point, and the conduction band minima were located at the R-point. Their second lowest conduction band was located at the Γ-point, whose energy level nearly equaled the R-point. For CAS (CASe), the partial density of the states shows the character of the Cu 3d and S 3p (Se 4p) orbitals at the top of the valence bands and the Sb 5p and S 3p (Se 4p) orbitals at the bottom of the conduction bands. The conduction bands of CAS and CASe have a p-orbital character (Sb 5p) that differs from the s-orbital character (In 5s) of CuInSe{sub 2}. It is for the reason that CAS and CASe do not have a chalcopyrite structure but a chalcostibite-type structure. The calculated absorption coefficient of CuSbS{sub 2} (10{sup 4}-10{sup 5} cm{sup −1}) is comparable to that of CuInSe{sub 2}. - Highlights: • We studied the features of CuSbS{sub 2} and CuSbSe{sub 2}, newly proposed photovoltaic compounds. • Chalcostibite phase is more stable in CuSbS{sub 2} and CuSbSe{sub 2}. • Band structures of CuSbS{sub 2} and CuSbS{sub 2} were calculated with HSE06 hybrid functional. • Absorption coefficient of chalcostibite-type CuSbS{sub 2} is comparable to that of CuInSe{sub 2}.

  10. First-principles study of electronic structure of CuSbS2 and CuSbSe2 photovoltaic semiconductors

    We studied the features of CuSbS2 (CAS) and CuSbSe2 (CASe), two proposed photovoltaic compounds, and clarified their electronic structures by first-principles calculations and compared them to the chalcopyrite-type CuInSe2 results. For both CAS and CASe, the calculated enthalpies of formation of the chalcostibite phases were considerably lower than those of the chalcopyrite phases. Therefore, we considered that the chalcostibite phase is more stable for CAS and CASe. In their band structure calculated with the HSE06 hybrid functional, the valence band maxima of CAS and CASe were located at the Γ-point, and the conduction band minima were located at the R-point. Their second lowest conduction band was located at the Γ-point, whose energy level nearly equaled the R-point. For CAS (CASe), the partial density of the states shows the character of the Cu 3d and S 3p (Se 4p) orbitals at the top of the valence bands and the Sb 5p and S 3p (Se 4p) orbitals at the bottom of the conduction bands. The conduction bands of CAS and CASe have a p-orbital character (Sb 5p) that differs from the s-orbital character (In 5s) of CuInSe2. It is for the reason that CAS and CASe do not have a chalcopyrite structure but a chalcostibite-type structure. The calculated absorption coefficient of CuSbS2 (104-105 cm−1) is comparable to that of CuInSe2. - Highlights: • We studied the features of CuSbS2 and CuSbSe2, newly proposed photovoltaic compounds. • Chalcostibite phase is more stable in CuSbS2 and CuSbSe2. • Band structures of CuSbS2 and CuSbS2 were calculated with HSE06 hybrid functional. • Absorption coefficient of chalcostibite-type CuSbS2 is comparable to that of CuInSe2

  11. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.

    Tambe, Mahesh; Pruikkonen, Sofia; Mäki-Jouppila, Jenni; Chen, Ping; Elgaaen, Bente Vilming; Straume, Anne Hege; Huhtinen, Kaisa; Cárpen, Olli; Lønning, Per Eystein; Davidson, Ben; Hautaniemi, Sampsa; Kallio, Marko J

    2016-03-15

    The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs. We demonstrate miR-493-3p to be a novel negative regulator of mitotic arrest deficient-2 (MAD2), an essential component of the spindle assembly checkpoint that monitors the fidelity of chromosome segregation. The microRNA targets the 3' UTR of Mad2 mRNA thereby preventing translation of the Mad2 protein. In cancer cells, overexpression of miR-493-3p induced a premature mitotic exit that led to increased frequency of aneuploidy and cellular senescence in the progeny cells. Importantly, excess of the miR-493-3p conferred resistance of cancer cells to microtubule drugs. In human neoplasms, miR-493-3p and Mad2 expression alterations correlated with advanced ovarian cancer forms and high miR-493-3p levels were associated with reduced survival of ovarian and breast cancer patients with aggressive tumors, especially in the paclitaxel therapy arm. Our results suggest that intratumoral profiling of miR-493-3p and Mad2 levels can have diagnostic value in predicting the efficacy of taxane chemotherapy. PMID:26943585

  12. Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.

    Kershaw, Christopher J; Costello, Joseph L; Talavera, David; Rowe, William; Castelli, Lydia M; Sims, Paul F G; Grant, Christopher M; Ashe, Mark P; Hubbard, Simon J; Pavitt, Graham D

    2015-01-01

    The PUF family of RNA-binding proteins regulate gene expression post-transcriptionally. Saccharomyces cerevisiae Puf3p is characterised as binding nuclear-encoded mRNAs specifying mitochondrial proteins. Extensive studies of its regulation of COX17 demonstrate its role in mRNA decay. Using integrated genome-wide approaches we define an expanded set of Puf3p target mRNAs and quantitatively assessed the global impact of loss of PUF3 on gene expression using mRNA and polysome profiling and quantitative proteomics. In agreement with prior studies, our sequencing of affinity-purified Puf3-TAP associated mRNAs (RIP-seq) identified mRNAs encoding mitochondrially-targeted proteins. Additionally, we also found 720 new mRNA targets that predominantly encode proteins that enter the nucleus. Comparing transcript levels in wild-type and puf3∆ cells revealed that only a small fraction of mRNA levels alter, suggesting Puf3p determines mRNA stability for only a limited subset of its target mRNAs. Finally, proteomic and translatomic studies suggest that loss of Puf3p has widespread, but modest, impact on mRNA translation. Taken together our integrated multi-omics data point to multiple classes of Puf3p targets, which display coherent post-transcriptional regulatory properties and suggest Puf3p plays a broad, but nuanced, role in the fine-tuning of gene expression. PMID:26493364

  13. Measurement of the positronium 1 3S1–2 3S1 interval by continuous-wave two-photon excitation

    Fee, M.; Chu, S.; Mills, A.; Chichester, R.; Zuckerman, D.; Shaw, E; Danzmann, K.

    1993-01-01

    Positronium is the quasistable bound system consisting of an electron and its antiparticle, the positron. Its energy levels can be explained to a high degree of accuracy by the electromagnetic interaction, affording an ideal test of the quantum electrodynamic (QED) theory of bound systems. We have measured the 1 3S1–2 3S1 interval in positronium by Doppler-free two-photon spectroscopy to be 1 233 607 216.4±3.2 MHz. We employ continous-wave (cw) excitation to eliminate the problems inherent wi...

  14. Crystal structure of methyl (2R,3S-3-[(tert-butylsulfinylamino]-2-fluoro-3-phenylpropanoate

    Zhiwei Zhao

    2015-12-01

    Full Text Available The title compound, C14H20FNO3S, contains two chiral carbon centres and the absolute configuration has been confirmed as (2R,3S. In the crystal, adjacent molecules are linked by weak C—H...O hydrogen bonds, generating zigzag chains along the a-axis direction.

  15. H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A.

    Kim, Se-Ryeon; Kim, Kee-Beom; Chae, Yun-Cheol; Park, Jin Woo; Seo, Sang-Beom

    2016-01-01

    Histone H3S10 phosphorylation has been known as a cell cycle-specific marker and has a role in transcriptional activation. Various kinases phosphorylate H3S10 in different species, however, the role of the mitotic serine/threonine protein kinase Aurora A (AURKA) is largely unknown. Here we present evidence that AURKA phosphorylates H3S10 and activates target gene transcription. We show that down-regulation of AURKA level during leukemia cell differentiation results in decreased H3S10 phosphorylation level. We further show that AURKA is recruited to target gene promoters and activates transcription via H3S10 phosphorylation. Furthermore, this recruitment can be disrupted by the AURKA inhibitor Alisertib and results in H3K9-me2 recruitment by G9a. PMID:26607113

  16. Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy.

    Ma, Wei; Ma, Chao-Nan; Zhou, Nan-Nan; Li, Xian-Dong; Zhang, Yi-Jie

    2016-01-01

    MicroRNAs (miRNAs) are believed to be resistant against radiotherapy in certain types of cancers. The aim of our study was to determine the clinical application of miRNAs in non-small cell lung cancer (NSCLC). Sixty NSCLC tissue samples and adjacent histologically normal tissues were obtained for miRNAs microarray analysis and validated by RT-qPCR. Correlation between miRNA expression level and clinicopathological features was evaluated. Our study examined the influence of changed miRNA expression on the damaged DNA and its associated radio sensitivity. Luciferase assay was performed to determine potential effects on the targeted gene. Our study identified fifteen altered miRNAs in which miR-328-3p was down regulated in NSCLC tumour tissue as compared to normal tissues. Down-expression of miR-328-3p was positively associated with an enhanced lymph node metastasis, advanced clinical stage and a shortened survival rate. miR-328-3p expression was decreased in A549 cells compared to other NSCLC cell lines. Up-regulation of miR-328-3p demonstrated a survival inhibition effect in A549 and restored NSCLC cells' sensitivity to radio therapy. An increased miR-328-3p expression promoted irradiation-induced DNA damage in cells. γ-H2AX was identified as the direct target of miR-328-3p. Over-expressed miR-328-3p can improve the radiosensitvity of cells by altering the DNA damage/repair signalling pathways in NSCLC. PMID:27530148

  17. Physico-chemical studies of MgNa3P3O10·12H2O

    Fahim I.

    2013-09-01

    Full Text Available A magnesium-sodium triphosphate MgNa3P3O10·12H2O already known has been prepared by the method of ion exchange resin of aqueous chemistry and studied by X-Ray diffraction, thermal analyses (TGA-DTA, differential scanning calorimetry (DSC and infrared spectrometry which show the characteristic bands of a triphosphate P3O. The results of differential thermal analysis, X-Ray powder diffraction and IR spectra of the compound heated at different temperatures showed that, after dehydration, MgNa3P3O10·12H2O decomposes into an amorphous compound, then it crystallizes at 600 ° C in order to give the anhydrous triphosphate MgNa3P3O10. MgNa3P3O10 is stable until its melting point at 612 ° C. Two different methods Ozawa and KAS have been selected in studying the kinetics of thermal behavior of the triphosphate P3O10 for the first time. The kinetic and thermodynamic characteristics of the dehydration of MgNa3P3O10·12H2O and the thermal phenomena accompanying this dehydration were determinated and discussed on the basis of the proposed crystalline structure.

  18. MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes.

    Li, Man; Wang, Nan; Zhang, Jian; He, Hong-Peng; Gong, Hui-Qin; Zhang, Rui; Song, Tie-Feng; Zhang, Li-Nan; Guo, Zhi-Xia; Cao, Dong-Sun; Zhang, Tong-Cun

    2016-07-01

    Transcription factor nuclear factor of activated T cells c4 (NFATc4) is the best-characterized target for the development of cardiac hypertrophy. Aberrant microRNA-29 (miR-29) expression is involved in the development of cardiac fibrosis and congestive heart failure. However, whether miR-29 regulates hypertrophic processes is still not clear. In this study, we investigated the potential functions of miR-29a-3p in endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy. We showed that miR-29a-3p was down-regulated in ET-1-treated H9c2 cardiomyocytes. Overexpression of miR-29a-3p significantly reduced ET-1-induced hypertrophic responses in H9c2 cardiomyocytes, which was accompanied by a decrease in NFATc4 expression. miR-29a-3p targeted directly to the 3'-UTR of NFATc4 mRNA and silenced NFATc4 expression. Our results indicate that miR-29a-3p inhibits ET-1-induced cardiomyocyte hypertrophy via inhibiting NFATc4 expression. PMID:26992639

  19. Soft-mode enhanced superconductivity in the antiperovskite APt{sub 3}P, A=Sr, Ca, La

    Heid, Rolf; Bohnen, Klaus-Peter [Institut fuer Festkoerperphysik, Karlsruher Institut fuer Technologie (Germany)

    2013-07-01

    The surprising discovery of superconductivity in iron pnictides initiated an increased search for superconductivity in other unconventional compounds. Recently, a new class of P-based antiperovskites was synthesized, and superconductivity with a T{sub c} of 8.4 K was observed for SrPt{sub 3}P. Specific heat measurements indicated a strong-coupling scenario and the presence of low-energy phonon modes. Replacing Sr by Ca or La resulted in lower T{sub c}'s and a progressive loss of strong-coupling signatures. Here we present results of a first principles study of lattice dynamics and electron-phonon coupling properties of APt{sub 3}P, A=Sr,Ca,La, with full consideration of spin-orbit interaction. For SrPt{sub 3}P, the coupling is carried almost totally by a single low-frequency branch consisting of planar Pt vibrations, which result in a coupling constant of λ∼2. In CaPt{sub 3}P this mode stiffens significantly thereby reducing λ to about 1, while in LaPt{sub 3}P the coupling is further reduced to 0.5 because of a shift of the electronic bands. In contrast to previous work, our ab initio results provide a consistent quantitative description of the key features of superconductivity in this new class of materials within the framework of the strong-coupling Eliashberg theory.

  20. Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch.

    Maria Poulou

    Full Text Available BACKGROUND: Present technology uses mostly chimeric proteins as regulators and hormones or antibiotics as signals to induce spatial and temporal gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that a chromosomally integrated yeast 'Leu3p-alpha-IotaRhoMu' system constitutes a ligand-inducible regulatory "off-on" genetic switch with an extensively dynamic action area. We find that Leu3p acts as an active transcriptional repressor in the absence and as an activator in the presence of alpha-isopropylmalate (alpha-IotaRhoMu in primary fibroblasts isolated from double transgenic mouse embryos bearing ubiquitously expressing Leu3p and a Leu3p regulated GFP reporter. In the absence of the branched amino acid biosynthetic pathway in animals, metabolically stable alpha-IPM presents an EC(50 equal to 0.8837 mM and fast "OFF-ON" kinetics (t(50ON = 43 min, t(50OFF = 2.18 h, it enters the cells via passive diffusion, while it is non-toxic to mammalian cells and to fertilized mouse eggs cultured ex vivo. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that the 'Leu3p-alpha-IotaRhoMu' constitutes a simpler and safer system for inducible gene expression in biomedical applications.

  1. Reactions of N+ (3P) ions with H2 and HD molecules at low temperatures

    Grozdanov, Tasko P.; McCarroll, Ronald; Roueff, Evelyne

    2016-04-01

    formation of ND+. The calculated value is consistent with the available experimental data. Conclusions: The present results allow for the determination of reaction rate coefficients for any given distribution of specific fine structure and rotational state populations of the reactants. In interstellar conditions, where N+ is in its 3P0 state and para- and ortho-H2 respectively in J = 0 and J = 1. Our results enable a study of the influence of the ortho/para evolution of molecular hydrogen on the formation of nitrogen compounds.

  2. M3S: the local network for electric wheelchairs and rehabilitation equipment.

    Linnman, S

    1996-09-01

    M3S is an open electric network standard for connecting rehabilitation equipment, especially electric modules in a wheelchair. It provides bidirectional communication at 250 kbaud via a CAN bus and extra safety lines for "Dead Man's Switch" and a TURN ON key. In an M3S system, the same input device may be used for controlling many different output devices in different operating modes. It provides flexible configuration tools for adapting the system for the individual user. M3S has been demonstrated and tested in more than ten different European development projects. PMID:8800222

  3. Experimental Conditions: SE3_S04_M01_D03 [Metabolonote[Archive

    Full Text Available SE3_S04_M01_D03 SE3 Comparison of fruit metabolites among tomato varieties 1 SE3_S0...4 Solanum peruvianum LA3858 Fruit SE3_S04_M01 6.7mg [MassBase ID] MDLC1_25535 SE3_MS1 LC-FT-ICR-MS ESI posit...ive method 1 SE3_DS3 PowerGet analysis for detection of all peaks (C2) 6|ITMS 2 SE3_AM1 PowerGet annotation A1 ...

  4. Regulatory role of the sequences downstream from nodD3 P1 promoter of Rhizobium meliloti

    2000-01-01

    The 660 bp region between nodD3 P1 promoter and the following coding region of Rhizobium meliloti has been studied.This region is designated "downstream sequences".It consists of two potential open reading frames,ORF1 and ORF2.Studies on the role of the downstream sequences on the activity of nodD3 P1 with nod D3(P1)-lacZ fusion show that deletion of the sequences containing ORF2 causes the increase of the activity of the fusion; on the contrary,addition of extra copies of ORF2 markedly decreases the activity of the fusion.These results indicate that the product of ORF2 plays a negative role in the expression of nod D3.

  5. Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.

    Pearce, D A; Nosel, S A; Sherman, F

    1999-04-01

    Although the gene responsible for Batten disease, CLN3, was positionally cloned in 1995, the function of Cln3p and the molecular basis of the disease still remain elusive. We previously reported that the yeast Saccharomyces cerevisiae contains a homolog to Cln3p, designated Btn1p, and that the human Cln3p complemented the pH-dependent resistance to D-(-)-threo-2-amino-1-[p-nitrophenyl]-1, 3-propanediol in btn1-Delta yeast mutants. We have determined that yeast lacking Btn1p have an elevated ability to acidify media during growth that correlates with an elevated plasma membrane ATPase activity. Btn1p may be involved in maintaining pH homeostasis of yeast cells. PMID:10191121

  6. Biomimetic-Inspired Infrared Sensors from Zn3P2 Microwires: Study of Their Photoconductivity and Infrared Spectrum Properties

    M. Israelowitz

    2014-01-01

    Full Text Available The fire beetle, Melanophila acuminata (Coleoptera: Buprestidae, senses infrared radiation at wavelengths of 3 and 10–25 microns via specialized protein-containing sensilla. Although the protein denatures outside of a biological system, this detection mechanism has inspired our bottom-up approach to produce single zinc phosphide microwires via vapour transport for IR sensing. The Zn3P2 microwires were immobilized and electrical contact was made by dielectrophoresis. Photoconductivity measurements have been extended to the near IR range, spanning the Zn3P2 band gaps. Purity and integrity of the Zn3P2 microwires including infrared light scattering properties were confirmed by infrared transmission microscopy. This biomimetic microwire shows promise for infrared chip development.

  7. Doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions in Debye plasmas

    Hu, Xiao-Qing; Wang, Yang; Kar, Sabyasachi, E-mail: skar@hit.edu.cn, E-mail: karsabyasachi@yahoo.com [Center for Theoretical Atomic and Molecular Physics, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080 (China); Jiang, Zishi [College of Physical Science and Technology, Heilongjiang University, Harbin 150080 (China); Jiang, Pinghui [College of Electrical and Information Engineering, Heilongjiang Institute of Technology, Harbin 150050 (China)

    2015-11-15

    We investigate the doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions Li{sup +}, Be{sup 2+}, B{sup 3+}, and C{sup 4+} by employing correlated exponential wave functions. In the framework of the stabilization method, we calculate two series (3pnp and 3dnd) of {sup 3}P{sup e} resonances below the N = 3 threshold. The {sup 3}P{sup e} resonance parameters (resonance energies and widths) are reported for the first time as a function of the screening parameter. For free-atomic cases, comparisons are made with the reported results and few resonance states are reported for the first time.

  8. Na*(3p)-Formation under grazing scattering of Na[sup +]-ions at an Al(111) surface

    Zimny, R. (Inst. fuer Kernphysik, Univ. Muenster (Germany)); Borisov, A.G. (Dept. of Physics, Moscow State Univ. (Russian Federation))

    1994-06-01

    Excited Na*(3p)-atoms are observed in grazing surface-collision experiments with Na[sup +]-beams. Such atoms can be formed beyond a certain threshold velocity via resonant electron transfer between atomic and metallic conduction band levels due to motion of the atom relative to the surface of the metal (''kinematic resonance''). This mechanism is studied here theoretically employing two different techniques: the nonperturbative ''Coupled Angular Mode'' (CAM) method and the approximate ''Transfer Hamiltonian'' (TH) method. The calculated Na*(3p)-populations agree well with recent experimental results. Moreover, the complete density matrix of the Na*(3p)-subspace has been computed with the TH-method for ion-energies between 10 and 300 keV. (orig.)

  9. Are Omega-3s Linked to Lower Risk for Fatal Heart Attack?

    ... Omega-3s Linked to Lower Risk for Fatal Heart Attack? These vital nutrients are found in seafood, nuts ... these people, nearly 8,000 suffered a first heart attack over time, which resulted in 2,781 deaths. ...

  10. Parcels and Land Ownership, 3S8W, Published in 2007, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset as of 2007. It is described as '3S8W'. Data by this publisher are often provided in UTM coordinate system; in a Transverse...

  11. Structure and properties of the mixed-valence compound Eu5Zr3S12

    Johrendt, Dirk; Jakubcova, Petra; Schappacher, Falko M.; Pöttgen, Rainer

    2009-01-01

    Abstract Needle shaped crystals of Eu5Zr3S12 and Eu3.67Sr1.33Zr3S12 were synthesized by solid state reactions of the elements and ZrS2 at 673-1273 K in alumina crucibles and their crystal structures were determined by single crystal methods. Both are isotypic with hexagonal symmetry (space group P-62m, Z = 1, Eu5Zr3S12: a = 1170.7(2), c = 394.27(8) pm, wR2 = 0.0636 for 552 F2 and 27 parameters; Eu3.67Sr1.33Zr3S12: a = 1167.0(2), c = 395.71(8) pm, wR2 = 0.0887 for 484 F2 and 29 para...

  12. Synthesis of Co3S4 Nanosheets and Their Superior Supercapacitor Property

    Xu, Bo; Pan, Lu; Zhu, Qiyong

    2016-03-01

    Sheet-like Co3S4 nanomaterial with high purity was synthesized via a facile and easily controlled one-step hydrothermal route. The structure and morphology of the as-synthesized sample was characterized by x-ray diffraction, transmission electron microscopy, and field emission scanning electron microscopy, respectively. The Co3S4 nanosheets with a mean size of 10 nm or so were used as electrode material and the supercapacitor property was determined. The results show that the specific capacitance of the Co3S4 nanosheets reaches 1037 F/g at 1 A/g. After 3000 charge-discharge recycles, the remained specific capacitance of the supercapacitor is 978 F/g, which is 94.3% of its initial value. The experiments indicate that the Co3S4 supercapacitor possesses high specific capacitance and excellent cyclic stability, which suggests its potential application in supercapacitor.

  13. BOT3P: a mesh generation software package for transport analysis with deterministic and Monte Carlo codes

    BOT3P consists of a set of standard Fortran 77 language programs that gives the users of the deterministic transport codes DORT, TORT, TWODANT, THREEDANT, PARTISN and the sensitivity code SUSD3D some useful diagnostic tools to prepare and check the geometry of their input data files for both Cartesian and cylindrical geometries, including graphical display modules. Users can produce the geometrical and material distribution data for all the cited codes for both two-dimensional and three-dimensional applications and, only in 3-dimensional Cartesian geometry, for the Monte Carlo Transport Code MCNP, starting from the same BOT3P input. Moreover, BOT3P stores the fine mesh arrays and the material zone map in a binary file, the content of which can be easily interfaced to any deterministic and Monte Carlo transport code. This makes it possible to compare directly for the same geometry the effects stemming from the use of different data libraries and solution approaches on transport analysis results. BOT3P Version 5.0 lets users optionally and with the desired precision compute the area/volume error of material zones with respect to the theoretical values, if any, because of the stair-cased representation of the geometry, and automatically update material densities on the whole zone domains to conserve masses. A local (per mesh) density correction approach is also available. BOT3P is designed to run on Linux/UNIX platforms and is publicly available from the Organization for Economic Cooperation and Development (OECD/NEA)/Nuclear Energy Agency Data Bank. Through the use of BOT3P, radiation transport problems with complex 3-dimensional geometrical structures can be modelled easily, as a relatively small amount of engineer-time is required and refinement is achieved by changing few parameters. This tool is useful for solving very large challenging problems, as successfully demonstrated not only in some complex neutron shielding and criticality benchmarks but also in a power

  14. Angle-integrated photoemission studies of ruthocuprate Eu_2-xCe_xRuSr_2Cu_2O_10, Gd_2RuSr_2Cu_2O_10 and Eu_1.5Nb_1-xRu_xCu_2O_10 systems

    Frazer, B.; Hirai, Y.; Rast, Simon; Felner, I.; Asaf, U.; Onellion, M.

    2000-03-01

    We report on both resonant photoemission and fixed photon energy studies of the conduction band and core levels for several ruthocuprate systems. The pure Ru-containing compounds exhibit ferromagnetic order, with metallic behavior and superconductivity depending on the rare earth and oxygen content. We report on as-prepared, hydrogen loaded, and oxygen-annealed polycrystalline samples. The Nb-Ru series changes from purely superconducting to both ferromagnetic and superconducting (Ru). The resonant photoemission measurements of the conduction band across the Ru4p, Cu3p, and Eu4d core levels allow us to determine the location and contribution of Ru, Cu and rare earth related states in the conduction band. The O1s, Cu2p, Ru3p, Ce4d, and Gd4d and several Nb core levels allow us to determine the valence of Ru and Nb, and the metallicity of the Ru/Nb, rare earth, and CuO2 planes.

  15. Establishing Forest Landscape Resources Information System Based on 3S Technique

    2003-01-01

    The application of Geographic Information System(GIS), Remote Sensing(RS) and Global Position System(GPS) in the research of forest landscape is outlined in this paper. The integration of the 3S technique is also described. In the 3S system, RS is used to obtain the various information of forest landscape. GPS is used to obtain the ground data of orientation and guide the people to the different places. And GIS is used in information management and processing.

  16. Progress in Spectroscopy of the 1S–3S Transition in Hydrogen

    Galtier, Sandrine, E-mail: sandrine.galtier@lkb.upmc.fr; Fleurbaey, Hélène; Thomas, Simon; Julien, Lucile; Biraben, François; Nez, François [Laboratoire Kastler Brossel, UPMC-Sorbonne Universités, CNRS, ENS-PSL Research University, Collège de France, 4 place Jussieu, Case 74, 75252 Paris Cedex 05 (France)

    2015-09-15

    We report the latest advances in the Doppler-free spectroscopy of the 1S–3S transition in hydrogen. A new continuous ultra-violet source has been developed and delivers a power level of 15 mW. With this setup, the statistical uncertainty on the 1S–3S transition frequency measurement is 2.2 kHz. Combined with the 1S–2S frequency, absolute accuracy at that level would significantly enlighten the proton radius puzzle.

  17. Application of 3S Techniques in the Study of Wetland Environment of Dong Ting Lake

    Xie, Baicheng; Zhang, Chunxia; Shuai, Xiqiang; Luo, Boliang

    2010-01-01

    Wetland is a multifunctional ecosystem in the earth, wetlands possess irreplaceable and enormous ecological functions and serve as an essential life supporting system. how to apply the new and high technology to the study of wetland has become the key point in wetland study area in our country. RS, GIS and GPS technology provide a new method for resource and ecological environment monitor. In this paper, the problem and development trend of 3S technology are discussed. Application of 3S techn...

  18. Progress in Spectroscopy of the 1S-3S Transition in Hydrogen

    Galtier, Sandrine; Fleurbaey, Hélène; Thomas, Simon; Julien, Lucile; Biraben, François; Nez, François

    2015-09-01

    We report the latest advances in the Doppler-free spectroscopy of the 1S-3S transition in hydrogen. A new continuous ultra-violet source has been developed and delivers a power level of 15 mW. With this setup, the statistical uncertainty on the 1S-3S transition frequency measurement is 2.2 kHz. Combined with the 1S-2S frequency, absolute accuracy at that level would significantly enlighten the proton radius puzzle.

  19. Lifetime measurement of the metastable 2{sup 3}P{sub 0} state in He-like uranium

    Toleikis, S. [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., MS 88R0192, Berkeley, CA 94720-8101 (United States) and Texas A and M University, College Station, TX (United States)]. E-mail: stoleikis@lbl.gov; Manil, B. [GANIL, Caen (France); Bednarz, G. [IFUJ, Cracow (Poland); Berdermann, E. [GSI, Darmstadt (Germany); Beyer, H.F. [GSI, Darmstadt (Germany); Bosch, F. [GSI, Darmstadt (Germany); Braeuning-Demian, A. [GSI, Darmstadt (Germany); Gumberidze, A. [GSI, Darmstadt (Germany); Indelicato, P. [Universite P. et M. Curie, Paris (France); Kozhuharov, C. [GSI, Darmstadt (Germany); Liesen, D. [GSI, Darmstadt (Germany); Marrus, R. [University of California, Berkeley, CA (United States); Mokler, P.H. [GSI, Darmstadt (Germany); Stachura, Z. [INP, Cracow (Poland); Stoehlker, T. [GSI, Darmstadt (Germany); Warczak, A. [IFUJ, Cracow (Poland)

    2005-07-01

    The lifetime of the 2{sup 3}P{sub 0} state in He-like uranium has been measured in a beam-foil time-of-flight experiment at the Gesellschaft fur Schwerionenforschung accelerator facility with the result {tau}(2{sup 3}P{sub 0})=58.2(9.5)ps. With the measured lifetime it is possible to derive a value of {delta}E{sub 2s}{sup Lamb}=76.3+/-20.6eV for the n=2 Lamb shift in uranium.

  20. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

    Gross, Andrew M.; Ryan K. Orosco; Shen, John P.; Egloff, Ann Marie; Carter, Hannah; Hofree, Matan; Choueiri, Michel; Charles S. Coffey; Lippman, Scott M.; Hayes, D. Neil; Cohen, Ezra E.; Grandis, Jennifer R.; Nguyen, Quyen T.; Ideker, Trey

    2014-01-01

    Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a propensity for metastasis and recurrence. Here we report a comprehensive analysis of the molecular and clinical features of HNSCC that govern patient survival. We find that TP53 mutation is frequently accompanied by loss of chromosome 3p, and that the combination of both events associates with a surprising decrease in survival rates (1.9 years versus >5 years for TP53 mutation alone). The TP53-3p inte...

  1. Spectroscopy of 1S0- 3P1 transition of magnesium atom in an external absorption cell

    Bagayev, S. N.; Baraulya, V. I.; Bonert, A. E.; Goncharov, A. N.; Seydaliev, M. R.

    2001-09-01

    The results of saturated absorption spectroscopy of the intercombination 1S0- 3P1 transition of magnesium atoms at 457 nm in an external absorption cell are presented. A laser system based on a Ti:Sa laser with frequency doubling in a LBO nonlinear crystal was used in these experiments. Saturated absorption resonances of magnesium in an external cell at the 1S0- 3P1 transition have been obtained for the first time. Pressure broadening of resonances equal to 12.5±1.5 kHz/mTorr has been measured.

  2. High lying energy positions of doubly (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} excited states of the beryllium atom

    Sakho, I., E-mail: aminafatima_sakho@yahoo.fr [UFR Sciences and Technologies, Department of physics, University of Ziguinchor, Ziguinchor (Senegal)

    2011-12-15

    The Screening Constant by Unit Nuclear Charge (SCUNC) method is used to study (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} autoionizing states of the beryllium atom. Energy positions are reported up to n=20. In addition, resonance widths of the (2pns) {sup 1}P{sup o} states also presented. The current results compared very well to available theoretical and experimental literature values up to n=15. The accurate data presented in this work may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be. - Highlights: > Accurate energy positions of (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} (n=3-20) autoionizing states of Be atoms. > Currently results compared very well to theoretical and experimental literature values up to n=15. > Presently data may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be.

  3. Experimental transition probabilities of the intercombination line 1s2ws21S0-1s22s3p3P01 in Be-like ions of Na through Si

    The decay of the 1s22s3p3 Po0,1,2 levels in Be-like ions of Na, Mg, Al and Si has been investigated using the beam-foil method. The mean wavelengths of the transition 1s22p23P0,1,2-1s22s3p 3Po0,1,2 and the lifetimes of the 1s22s3p 3Po0,1,2 levels have been measured. An intercomparison of these lifetimes yields the transition probability of the intercombination line 1s22s21S0-1s22s3p 3Po1. The results are (3.45 ± 0.73) 109 s-1 in Na VIII, (5.55 ± 0.96) 109 s-1 in Mg IX, (1.21 ± 0.24) 1010 s-1 in Al X and (2.50 ± 0.54) 1010 s-1 in Si XI. (orig.)

  4. Parity nonconservation effect with laser-induced 2^3S_1 - 2^1S_0 transition in heavy heliumlike ions

    Shabaev, V M; Kozhuharov, C; Plunien, G; Stöhlker, Th

    2010-01-01

    The parity nonconservation (PNC) effect on the laser-induced 2^3S_1 - 2^1S_0 transition in heavy heliumlike ions is considered. A simple analytical formula for the PNC correction to the cross section is derived for the case, when the opposite-parity 2^1S_0 and 2^3P_0 states are almost degenerate and, therefore, the PNC effect is strongly enhanced. Numerical results are presented for heliumlike gadolinium and thorium, which seem most promising candidates for such kind of experiments. In both Gd and Th cases the photon energy required will be anticipated with a high-energy laser built at GSI. Alternatively, it can be gained with ultraviolet lasers utilizing relativistic Doppler tuning at FAIR facilities in Darmstadt.

  5. Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma

    Houben Roland

    2005-12-01

    Full Text Available Abstract Background Activation of Ras or Raf contributes to tumorigenesis of melanoma. However, constitutive Raf activation is also a characteristic of the majority of benign melanocytic nevi and high intensity signaling of either Ras or Raf was found to induce growth inhibition and senescence rather than transformation. Since the chromosome 3p kinase (3pK is a target of the Ras/Raf/Mek/Erk signaling pathway which antagonizes the function of the oncogene and anti-differentiation factor Bmi-1, 3pK may function as a tumor suppressor in tumors with constitutive Ras/Raf activation. Consequently, we tested whether inactivating 3pK mutations are present in melanoma. Methods 30 metastatic melanoma samples, which were positive for activating mutations of either BRaf or NRas, were analyzed for possible mutations in the 3pk gene. The 10 coding exons and their flanking intron sequences were amplified by PCR and direct sequencing of the PCR products was performed. Results This analysis revealed that besides the presence of some single nucleotide polymorphisms in the 3pk gene, we could not detect any possible loss of function mutation in any of these 30 metastatic melanoma samples selected for the presence of activating mutations within the Ras/Raf/Mek/Erk signaling pathway. Conclusion Hence, in melanoma with constitutively active Ras/Raf inactivating mutations within the 3pk gene do not contribute to the oncogenic phenotype of this highly malignant tumor.

  6. LEAN MANUFACTURING: CONTINUOUS IMPROVEMENT OF PRODUCTIVITY USING KAIZEN 3P PHILOSOPHY IN A LARGE SIZED COMPANY IN BOTUCATU, SP, BRAZIL

    Fernando Doriguel

    2015-06-01

    Full Text Available The search for excellence in a company´s production occurs mainly from developing reputable philosophies by training and monitoring groups which are formed by the company itself. Due to such factors as well as the necessity to increase excellence in production, new methodologies as Kaizen 3P (Production Preparation Process is still little known. This paper aims at deploying Lean Manufacturing which used Kaizen 3P method in a production line in order to reduce the operator time in production as wellas to reduce the product cycling time in assembling line. Results showed that Kaizen 3P method used in the company reduced man hour (MH in all the process reduction 660 hours. Furthermore assembling line had a time reduction 200 hours. Product route had a reduction of 17,6 kilometers. It was possible to conclude that the correct use of Kaizen 3P tool based on Lean manufacturing showed significant and productive gains when compared to old working methods adopted by the company.

  7. 78 FR 12130 - Social Security Ruling, SSR 13-3p; Appeal of an Initial Medical Disability Cessation...

    2013-02-21

    ... Social Security--Disability Insurance; 96.004 Social Security--Survivors Insurance; 96.006 Supplemental... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Social Security Ruling, SSR 13-3p; Appeal of an Initial Medical Disability Cessation...

  8. Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia.

    Piscopo, Paola; Grasso, Margherita; Fontana, Francesca; Crestini, Alessio; Puopolo, Maria; Del Vescovo, Valerio; Venerosi, Aldina; Calamandrei, Gemma; Vencken, Sebastian F; Greene, Catherine M; Confaloni, Annamaria; Denti, Michela A

    2016-01-01

    Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and is activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial frontotemporal lobar degeneration (FTLD). PGRN has a neurotrophic and anti-inflammatory activity, and it is neuroprotective in several injury conditions, such as oxygen or glucose deprivation, oxidative injury, and hypoxic stress. Indeed, we have previously demonstrated that hypoxia induces the up-regulation of GRN transcripts. Several studies have shown microRNAs (miRNAs) involvement in hypoxia. Moreover, in FTLD patients with a genetic variant of GRN (rs5848), the reinforcement of miR-659-3p binding site has been suggested to be a risk factor. Here, we report that miR-659-3p interacts directly with GRN 3'UTR as shown by luciferase assay in HeLa cells and ELISA and Western Blot analysis in HeLa and Kelly cells. Moreover, we demonstrate the physical binding between GRN mRNA and miR-659-3p employing a miRNA capture-affinity technology in SK-N-BE and Kelly cells. In order to study miRNAs involvement in hypoxia-mediated up-regulation of GRN, we evaluated miR-659-3p levels in SK-N-BE cells after 24 h of hypoxic treatment, finding them inversely correlated to GRN transcripts. Furthermore, we analyzed an animal model of asphyxia, finding that GRN mRNA levels increased at post-natal day (pnd) 1 and pnd 4 in rat cortices subjected to asphyxia in comparison to control rats and miR-659-3p decreased at pnd 4 just when GRN reached the highest levels. Our results demonstrate the interaction between miR-659-3p and GRN transcript and the involvement of miR-659-3p in GRN up-regulation mediated by hypoxic/ischemic insults. PMID:27199656

  9. Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis

    Shinya Takigawa

    2016-02-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs that play a mostly post-transcriptional regulatory role in gene expression. Using RAW264.7 pre-osteoclast cells and genome-wide expression analysis, we identified a set of miRNAs that are involved in osteoclastogenesis. Based on in silico analysis, we specifically focused on miR-222-3p and evaluated its role in osteoclastogenesis. The results show that the inhibitor of miR-222-3p upregulated the mRNA levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1 and tartrate-resistant acid phosphatase (TRAP, while its mimicking agent downregulated their mRNA levels. Western blot analysis showed that its inhibitor increased the protein levels of TRAP and cathepsin K, while its mimicking agent decreased their levels. Genome-wide mRNA expression analysis in the presence and absence of receptor activator of nuclear factor κ-B ligand (RANKL predicted c-Src as a potential regulatory target of miR-222-3p. Live cell imaging using a fluorescence resonance energy transfer (FRET technique revealed that miR-222-3p acted as an inhibitor of c-Src activity, and a partial silencing of c-Src suppressed RANKL-induced expression of TRAP and cathepsin K, as well as the number of multi-nucleated osteoclasts and their pit formation. Collectively, the study herein demonstrates that miR-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K and TRAP.

  10. Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction.

    Coskunpinar, Ender; Cakmak, Huseyin Altug; Kalkan, Ali Kemal; Tiryakioglu, Necip Ozan; Erturk, Mehmet; Ongen, Zeki

    2016-10-10

    Recent studies have reported circulating microRNAs (miRNAs) as novel biomarkers for cardiovascular diseases including acute myocardial infarction, heart failure, diabetes mellitus, stroke, and acute pulmonary embolism. The aims of this study were 1) to compare the plasma expression levels of miRNAs in patients with acute coronary syndrome (ACS) and control subjects and in ST-elevation myocardial infarction (STEMI) and non-STEMI 2) to evaluate miRNAs potential to be used as novel diagnostic biomarkers for ACS. Twenty seven consecutive patients, admitted to emergency department of a training and research hospital between January-December 2013 with acute chest pain and/or dyspnea and diagnosed with ACS, and 16 non-ACS control subjects were included in this study. miRNA profiling was performed by using real time polymerase chain reaction. Functions of dysregulated miRNAs were evaluated by computerized-pathways analysis. miR-221-3p was one of the two most dysregulated miRNAs with a fold regulation of 3.89. It was significantly positively correlated with both Troponin and GRACE and Synthax Score. Moreover, miR221-3p was found to be significantly inversely correlated with left ventricular ejection fraction. miR-221-3p was the most prominent biomarker candidate with an area under curve (AUC) level of 0.881 (95% confidence interval: 0.774-0.987; p=0.002). The present study is the first to report an increased expression levels of miR-221-3p in AMI. Since miR-221-3p has a high discriminative value and significant relations with Troponin, GRACE and Synthax score and left ventricular systolic function, it may be a potential biomarker for early prediction of AMI. PMID:27374153

  11. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes

    Sadanand Fulzele

    2015-01-01

    Full Text Available Hyperglycemia- (HG- Amadori-glycated albumin- (AGA- induced activation of microglia and monocytes and their adherence to retinal vascular endothelial cells contribute to retinal inflammation leading to diabetic retinopathy (DR. There is a great need for early detection of DR before demonstrable tissue damages become irreversible. Extracellular adenosine, required for endogenous anti-inflammation, is regulated by the interplay of equilibrative nucleoside transporter with adenosine deaminase (ADA and adenosine kinase. ADA, including ADA1 and ADA2, exists in all organisms. However, because ADA2 gene has not been identified in mouse genome, how diabetes alters adenosine-dependent anti-inflammation remains unclear. Studies of pig retinal microglia and human macrophages revealed a causal role of ADA2 in inflammation. Database search suggested miR-146b-3p recognition sites in the 3′-UTR of ADA2 mRNA. Coexpression of miR-146b-3p, but not miR-146-5p or nontargeting miRNA, with 3′-UTR of the ADA2 gene was necessary to suppress a linked reporter gene. In the vitreous of diabetic patients, decreased miR-146b-3p is associated with increased ADA2 activity. Ectopic expression of miR-146b-3p suppressed ADA2 expression, activity, and TNF-α release in the AGA-treated human macrophages. These results suggest a regulatory role of miR-146b-3p in diabetes related retinal inflammation by suppressing ADA2.

  12. Optical dynamics of MgO/Ga4Se3S interface

    Highlights: • A p–n interface made of MgO as an optical window to Ga4Se3S crystals is designed. • The device is studied by means of transmittance, reflectance and absorbance. • The reflection dependence on incident angle is investigated in the range of 30–80°. • The Brewster angles for the layers are determined. • The strong absorption domination conditions are reported. -- Abstract: A new p–n interface made of p-type MgO as an optical window to the n-type Ga4Se3S crystals is investigated by means of optical reflectance, transmittance and absorbance in the incident light wavelength (λ) range of 200–1100 nm. The reflectivity spectral analysis as a function of angle of incidence for MgO, Ga4Se3S and the Ga4Se3S/MgO layers revealed Brewster angles of 75°, 80° and 70° with the corresponding dielectric constants of 13.93, 32.16 and εMgO=7.55εGa4Se3S, respectively. To remove Brewster condition of reflection and obtain maximum absorption, the light must be incident from the MgO side. A novel light absorbability is observed. Namely, for all λ 4Se3S layer. For larger λ values, while the crystal absorbance decreases significantly, the bilayer absorbance increased by four times in the visible range and three times in the IR range of spectrum. In the MgO layer, two distinct sets of band tails of the localized states with the widths of 2.30 and 1.26 eV are determined from the absorption spectral analysis. These band tails shift up to 2.32 and 1.44 eV when the interface is constructed. In addition, an indirect energy band gaps (Eg) which are located at 3.10, 2.13 and 1.90 eV for the MgO, Ga4Se3S and the Ga4Se3S/MgO layers, respectively, are determined. The Eg value of the crystal shifts by a 0.23 eV upon bilayer construction. The reflection properties, the band tails, the energy gaps and related shifts make the Ga4Se3S/MgO interface attractive for fabrication of solar cells, narrow barrier resonant tunneling diodes or quantum dots, and as an optical

  13. MAP3S/RAINE biennial progress report for the period FY 1980-FY 1981

    1981-11-01

    Research accomplished under the MAP3S/RAINE program during the two-year period ending on October 1, 1981 is reported. Load shifting to meet unanticipated demands occurred frequently throughout this two-year period, with the result that new activities were introduced to the program and some scheduled activities deferred or deleted. Therefore the report is organized in a format to present both the scheduled and unscheduled activities. The first section provides a broad overview of the total program from a management perspective, indicating major decision points, accomplishments, and the rationale for the decision-paths chosen. The next section is a summary of unscheduled activities in MAP3S/RAINE that pertain to the first two categories noted above. The next section describes the major element of the third class of deviation, namely the OSCAR experiment. The following section presents the activity summaries, which constitute a major portion of the report. As noted above, these pertain to originally scheduled research components, and thus are a direct measure of scientific productivity. The next and final section provides an indexed listing of MAP3S/RAINE publications, and describes the future MAP3S/RAINE-dedicated issue of Atmospheric Environment, which is a major final product of the 1980-81 MAP3S/RAINE phase.

  14. Multifunctional Co3S4/graphene composites for lithium ion batteries and oxygen reduction reaction.

    Mahmood, Nasir; Zhang, Chenzhen; Jiang, Jie; Liu, Fei; Hou, Yanglong

    2013-04-15

    Cobalt sulfide is a good candidate for both lithium ion batteries (LIBs) and cathodic oxygen reduction reaction (ORR), but low conductivity, poor cyclability, capacity fading, and structural changes hinder its applications. The incorporation of graphene into Co3S4 makes it a promising electrode by providing better electrochemical coupling, enhanced conductivity, fast mobility of ions and electrons, and a stabilized structure due to its elastic nature. With the objective of achieving high-performance composites, herein we report a facile hydrothermal process for growing Co3S4 nanotubes (NTs) on graphene (G) sheets. Electrochemical impedance spectroscopy (EIS) verified that graphene dramatically increases the conductivity of the composites to almost twice that of pristine Co3S4. Electrochemical measurements indicated that the as-synthesized Co3S4/G composites exhibit good cyclic stability and a high discharge capacity of 720 mA h g(-1) up to 100 cycles with 99.9% coulombic efficiency. Furthermore, the composites react with dissolved oxygen in the ORR by four- and two-electron mechanisms in both acidic and basic media with an onset potential close to that of commercial Pt/C. The stability of the composites is much higher than that of Pt/C, and exhibit high methanol tolerance. Thus, these properties endorse Co3 S4 /G composites as auspicious candidates for both LIBs and ORR. PMID:23447515

  15. Investigation of the bonding of SiHn and CHn (n = 1,…,3) on Cu(1 1 1) using DFT

    Shuttleworth, I. G.

    2012-07-01

    The interaction of SiHn and CHn (n = 1,…,3) fragments with the three-fold sites of Cu(1 1 1) has been investigated using LCAO-DFT. The binding site preference for the HCP site (SiHn) has been shown to be due to the removal of unoccupied Si 3p-Cu 4s anti-bonding states by the second layer Cu ion cores. A similar but less pronounced effect is shown between the C 2p-Cu 4s interaction for CHn fragments bound in the FCC site.

  16. Communication: Direct measurements of nascent O(3P0,1,2) fine-structure distributions and branching ratios of correlated spin-orbit resolved product channels CO(ã3Π; v) + O(3P0,1,2) and CO(Χ~1Σ+; v) + O(3P0,1,2) in VUV photodissociation of CO2

    We present a generally applicable experimental method for the direct measurement of nascent spin-orbit state distributions of atomic photofragments based on the detection of vacuum ultraviolet (VUV)-excited autoionizing-Rydberg (VUV-EAR) states. The incorporation of this VUV-EAR method in the application of the newly established VUV-VUV laser velocity-map-imaging-photoion (VMI-PI) apparatus has made possible the branching ratio measurement for correlated spin-orbit state resolved product channels, CO(ã3Π; v) + O(3P0,1,2) and CO(Χ~1Σ+; v) + O(3P0,1,2), formed by VUV photoexcitation of CO2 to the 4s(101) Rydberg state at 97,955.7 cm−1. The total kinetic energy release (TKER) spectra obtained from the O+ VMI-PI images of O(3P0,1,2) reveal the formation of correlated CO(ã3Π; v = 0–2) with well-resolved v = 0–2 vibrational bands. This observation shows that the dissociation of CO2 to form the spin-allowed CO(ã3Π; v = 0–2) + O(3P0,1,2) channel has no potential energy barrier. The TKER spectra for the spin-forbidden CO(Χ~1Σ+; v) + O(3P0,1,2) channel were found to exhibit broad profiles, indicative of the formation of a broad range of rovibrational states of CO(Χ~1Σ+)  with significant vibrational populations for v = 18–26. While the VMI-PI images for the CO(ã3Π; v = 0–2) + O(3P0,1,2) channel are anisotropic, indicating that the predissociation of CO2 4s(101) occurs via a near linear configuration in a time scale shorter than the rotational period, the angular distributions for the CO(Χ~1Σ+; v) + O(3P0,1,2) channel are close to isotropic, revealing a slower predissociation process, which possibly occurs on a triplet surface via an intersystem crossing mechanism

  17. Oscillator strength of the strongly 'forbidden' Pb 6p{sup 2} {sup 3}P{sub 0}{yields}6p{sup 2} {sup 3}P{sub 1} transition at 1278.9 nm

    Vadla, C.; Horvatic, V. [Inst. of Physics, Zagreb (Croatia); Niemax, K. [Inst. of Spectrochemistry and Applied Spectroscopy (ISAS), Dortmund (Germany)

    2001-04-01

    The 'forbidden' Pb 6p{sup 2} {sup 3}P{sub 0}{yields}6p{sup 2} {sup 3}P{sub 1} line at 1278.9 nm is measured by diode laser absorption in a resistively heated hot-pipe filled with a lead vapour and argon as buffer gas. The measurements performed at a temperature of 1170 K and a lead number density of 2.4 x 10{sup 15} cm{sup -3} yield the oscillator strength f{sub F}=(4.5{+-}1.1) x 10{sup -7} which corresponds to a radiative transition probability A{sub F}=(6.1{+-}1.5) s{sup -1}. Within the error bars, the result is in agreement with theoretical data published by different authors. (orig.)

  18. Electron capture into the 3s state of atomic hydrogen by H+ on Kr and Xe

    Absolute cross sections for electron capture into the 3s state of atomic hydrogen have been measured for 10-150-keV proton impact on Kr and Xe. The experimental procedure involved the quantitative measurement of the Balmer-alpha radiation emitted by the spontaneous decay of fast hydrogen atoms in flight. The 3s-state radiation was identified by its characteristic lifetime. The cross sections for both target gases reach a maximum in the projectile energy range under consideration. The Xe cross sections are approximately 40% higher than those for Kr near 25 keV but are similar above 80 keV. These values are consistent with existing 3s cross-section measurements and with an n-3 scaling of existing total electron-capture cross sections in accordance with Born-approximation predictions

  19. Heazlewoodite, Ni3S2: A Potent Catalyst for Oxygen Reduction to Water under Benign Conditions.

    Falkowski, Joseph M; Concannon, Nolan M; Yan, Bing; Surendranath, Yogesh

    2015-07-01

    Electrodeposited thin films and nanoparticles of Ni3S2 are highly active, poison- and corrosion-resistant catalysts for oxygen reduction to water at neutral pH. In pH 7 phosphate buffer, Ni3S2 displays catalytic onset at 0.8 V versus the reversible hydrogen electrode, a Tafel slope of 109 mV decade(-1), and high faradaic efficiency for four-electron reduction of O2 to water. Under these conditions, the activity and stability of Ni3S2 exceeds that of polycrystalline platinum and manganese, nickel, and cobalt oxides, illustrating the catalytic potential of pairing labile first-row transition metal active sites with a more covalent sulfide host lattice. PMID:26101848

  20. BOREAS Level-3s Landsat TM Imagery Scaled At-sensor Radiance in LGSOWG Format

    Nickeson, Jaime; Knapp, David; Newcomer, Jeffrey A.; Cihlar, Josef; Hall, Forrest G. (Editor)

    2000-01-01

    For BOReal Ecosystem-Atmosphere Study (BOREAS),the level-3s Landsat Thematic Mapper (TM) data, along with the other remotely sensed images,were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy,detailed land cover, and biophysical parameter maps such as Fraction of Photosynthetically Active Radiation (FPAR) and Leaf area Index (LAI). CCRS collected and supplied the level-3s images to BOREAS for use in the remote sensing research activities. Geographically,the bulk of the level-3s images cover the BOREAS Northern Study Area (NSA) and Southern Study Area (SSA) with a few images covering the area between the NSA and SSA. Temporally,the images cover the period of 22-Jun-1984 to 30-Jul-1996. The images are available in binary,image-format files.

  1. Compositional disorder and its effect on the thermoelectric performance of Zn3P2 nanowire–copper nanoparticle composites

    Recent studies indicated that nanowire format of materials is ideal for enhancing the thermoelectric performance of materials. Most of these studies were performed using individual nanowires as the test elements. It is not currently clear whether bulk assemblies of nanowires replicate this enhanced thermoelectric performance of individual nanowires. Therefore, it is imperative to understand whether enhanced thermoelectric performance exhibited by individual nanowires can be extended to bulk assemblies of nanowires. It is also imperative to know whether the addition of metal nanoparticle to semiconductor nanowires can be employed for enhancing their thermoelectric performance further. Specifically, it is important to understand the effect of microstructure and composition on the thermoelectric performance on bulk compound semiconductor nanowire–metal nanoparticle composites. In this study, bulk composites composed of mixtures of copper nanoparticles with either unfunctionalized or 1,4-benzenedithiol (BDT) functionalized Zn3P2 nanowires were fabricated and analyzed for their thermoelectric performance. The results indicated that use of BDT functionalized nanowires for the fabrication of composites leads to interface-engineered composites that have uniform composition all across their cross-section. The interface engineering allows for increasing their Seebeck coefficients and electrical conductivities, relative to the Zn3P2 nanowire pellets. In contrast, the use of unfunctionalized Zn3P2 nanowires for the fabrication of composite leads to the formation of composites that are non-uniform in composition across their cross-section. Ultimately, the composites were found to have Zn3P2 nanowires interspersed with metal alloy nanoparticles. Such non-uniform composites exhibited very high electrical conductivities, but slightly lower Seebeck coefficients, relative to Zn3P2 nanowire pellets. These composites were found to show a very high zT of 0.23 at 770 K, orders of

  2. Nuclear regulatory policy concept on safety, security, safeguards and emergency preparedness (3S+EP)

    Regulatory Policy is formulated in regulations that stipulate the assurance of workers and public safety and environmental protection. Legislation and regulations on nuclear energy should consider nuclear safety, security and safeguards, as well as nuclear emergency preparedness (3S+EP) and liability for nuclear damage. Specific requirements stipulated in international conventions and agreements should also be taken into account. Regulatory Policy is formulated in regulations that stipulate the assurance of workers and public safety and environmental protection. Legislation and regulations on nuclear energy should consider nuclear safety, security and safeguards, as well as nuclear emergency preparedness (3S+EP) and liability for nuclear damage. Specific requirements stipulated in international conventions and agreements should also be taken into account. By undertaking proper regulatory oversight on Safety, Security and Emergency Preparedness (3S+EP) as an integrated and comprehensive system, safe and secure use of nuclear energy can be assured. Licence requirements and conditions should fulfil regulatory requirements pertaining to 3S+EP for nuclear installation as an integrated system. An effective emergency capacity that can be immediately mobilized is important. The capacity in protecting the personnel before, during and after the disaster should also be planned. Thus, proper emergency preparedness should be supported by adequate resources. The interface between safety, security, safeguards and emergency preparedness has to be set forth in nuclear regulations, such as regulatory requirements; 3S+EP; components, systems and structures of nuclear installations and human resources. Licensing regulations should stipulate, among others, DIQ, installations security system, safety analysis report, emergency preparedness requirements and necessary human resources that meet the 3S+EP requirements.

  3. Theoretical Studies of the Reaction Mechanisms of CH3S + NO2

    2002-01-01

    The potential energy surface for the CH3S + NO2 reaction has been studied using the ab initio G3 (MP2) method. A variety of possible complexes and saddle points along the minimum energy reaction paths have been characterized at UMP2 (full)/6-31G(d) level. The calculations reveal dominating reaction mechanisms of the title reaction: CH3S + NO2 firstly produce intermediate CH3SONO, then break up into CH3SO + NO. The results are valuable to understand the atmospheric sulfur compounds oxidation mechanism.

  4. 4th International Symposium on Sensor Science (I3S2015: Conference Report

    Peter Seitz

    2015-09-01

    Full Text Available An international scientific conference was sponsored by the journal Sensors under the patronage of the University of Basel. The 4th edition of the International Symposium on Sensor Science (I3S2015 ran from 13 to 15 July 2015 in Basel, Switzerland. It comprised five plenary sessions and one morning with three parallel sessions. The conference covered the most exciting aspects and the latest developments in sensor science. The conference dinner took place on the second evening of the conference. The I3S2015 brought together 170 participants from 40 different countries. [...

  5. Application of 3S Technology in Dynamic Monitoring of Capital Farmland

    Xiaoyan; WANG; Guoye; REN

    2013-01-01

    Firstly,this paper introduces current situations of protection of capital farmland. According to current situations,it analyzes significance in protecting capital farmland and significance and functions of application of 3S technology in dynamic monitoring of capital farmland. With the aid of examples,it discusses functions of remote sensing and GIS in dynamic monitoring of capital farmland. It is believed that 3S technology not only can provide accurate parcel data of capital farmland changes for reviewing land change survey,but also can provide data for monitoring development situations of capital farmland,as well as provide basic current information for decision-making department.

  6. Near-infrared radiation absorption properties of covellite (CuS using first-principles calculations

    Lihua Xiao

    2016-08-01

    Full Text Available First-principles density functional theory was used to investigate the electronic structure, optical properties and the origin of the near-infrared (NIR absorption of covellite (CuS. The calculated lattice constant and optical properties are found to be in reasonable agreement with experimental and theoretical findings. The electronic structure reveals that the valence and conduction bands of covellite are determined by the Cu 3d and S 3p states. By analyzing its optical properties, we can fully understand the potential of covellite (CuS as a NIR absorbing material. Our results show that covellite (CuS exhibits NIR absorption due to its metal-like plasma oscillation in the NIR range.

  7. Photoassociation spectroscopy of long-range molecular states below the 2s + 3p 6Li2 asymptote

    Gross, Christian; Chaudhuri, Saptarishi; Gan, Jaren; Dieckmann, Kai

    2015-05-01

    We present photoassociation spectra of high-lying vibrational states of the interatomic potentials correlating to the 2s + 3p asymptote of 6Li2 . Starting from an atomic cloud in a magneto-optical trap we first drive a free-to-bound transition into a molecular bound state using a tunable ultra-violet laser. Thereafter we ionize these long-range molecules using a 532 nm laser and detect the resulting ions with a channeltron. We determine the absolute positions of the transitions with MHz precision utilizing a frequency comb based calibration. Lithium dimers are extensively studied theoretically using various models and methods. Spectroscopic measurements are crucial to test and benchmark these methods and are available for various electronic states and inter-nuclear distances of 6Li2 molecule. Our study provides the first experimental observation of long-range states of the 2s + 3p asymptote of 6Li2 .

  8. Efficient transfer hydrogenation reaction Catalyzed by a dearomatized PN 3P ruthenium pincer complex under base-free Conditions

    He, Lipeng

    2012-03-01

    A dearomatized complex [RuH(PN 3P)(CO)] (PN 3PN, N′-bis(di-tert-butylphosphino)-2,6-diaminopyridine) (3) was prepared by reaction of the aromatic complex [RuH(Cl)(PN 3P)(CO)] (2) with t-BuOK in THF. Further treatment of 3 with formic acid led to the formation of a rearomatized complex (4). These new complexes were fully characterized and the molecular structure of complex 4 was further confirmed by X-ray crystallography. In complex 4, a distorted square-pyramidal geometry around the ruthenium center was observed, with the CO ligand trans to the pyridinic nitrogen atom and the hydride located in the apical position. The dearomatized complex 3 displays efficient catalytic activity for hydrogen transfer of ketones in isopropanol. © 2011 Elsevier B.V. All rights reserved.

  9. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells’ sensitivity to paclitaxel

    Tambe, Mahesh; Pruikkonen, Sofia; Mäki-Jouppila, Jenni; Ping CHEN; Elgaaen, Bente Vilming; Straume, Anne Hege; Huhtinen, Kaisa; Cárpen, Olli; Lønning, Per Eystein; Davidson, Ben; Hautaniemi, Sampsa; Kallio, Marko J.

    2016-01-01

    The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs. We demonstrate miR-493-3p to be a novel negative regulator of mitotic arrest deficient-2 (MAD2), an...

  10. Wakefield Simulation of CLIC PETS Structure Using Parallel 3D Finite Element Time-Domain Solver T3P

    Candel, A.; Kabel, A.; Lee, L.; Li, Z.; Ng, C.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; /CERN

    2009-06-19

    In recent years, SLAC's Advanced Computations Department (ACD) has developed the parallel 3D Finite Element electromagnetic time-domain code T3P. Higher-order Finite Element methods on conformal unstructured meshes and massively parallel processing allow unprecedented simulation accuracy for wakefield computations and simulations of transient effects in realistic accelerator structures. Applications include simulation of wakefield damping in the Compact Linear Collider (CLIC) power extraction and transfer structure (PETS).

  11. Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfaces

    Zhao, Xiaomin; Daniels, Karla J.; Oh, Soon-Hwan; GREEN, CLAYTON B.; Yeater, Kathleen M; Soll, David R.; Hoyer, Lois L.

    2006-01-01

    Candida albicans ALS3 encodes a large cell-surface glycoprotein that has adhesive properties. Immunostaining of cultured C. albicans germ tubes showed that Als3p is distributed diffusely across the germ tube surface. Two-photon laser scanning microscopy of model catheter biofilms grown using a PALS3-green fluorescent protein (GFP) reporter strain showed GFP production in hyphae throughout the biofilm structure while biofilms grown using a PTPI1-GFP reporter strain showed GFP in both hyphae an...

  12. The fast C(3P) + CH3OH reaction as an efficient loss process for gas-phase interstellar methanol

    Shannon, Robin J; Loison, Jean-Christophe; Caubet, Philippe; Balucani, Nadia; Seakins, Paul W; Wakelam, Valentine; Hickson, Kevin M

    2014-01-01

    Rate constants for the C(3P) + CH3OH reaction have been measured in a continuous supersonic flow reactor over the range 50 K to 296 K. C(3P) was created by the in-situ pulsed laser photolysis of CBr4, a multiphoton process which also produced some C(1D), allowing us to investigate simultaneously the low temperature kinetics of the C(1D) + CH3OH reaction. C(1D) atoms were followed by an indirect chemiluminescent tracer method in the presence of excess CH3OH. C(3P) atoms were detected by the same chemiluminescence technique and also by direct vacuum ultra-violet laser induced fluorescence (VUV LIF). Secondary measurements of product H(2S) atom formation have been undertaken allowing absolute H atom yields to be obtained by comparison with a suitable reference reaction. In parallel, statistical calculations have been performed based on ab-initio calculations of the complexes, adducts and transition states (TSs) relevant to the title reaction. By comparison with the experimental H atom yields, the preferred react...

  13. miR-130b-3p Upregulation Contributes to the Development of Thyroid Adenomas Targeting CCDC6 Gene

    Leone, Vincenza; Langella, Concetta; Esposito, Francesco; De Martino, Marco; Decaussin-Petrucci, Myriam; Chiappetta, Gennaro; Bianco, Antonio; Fusco, Alfredo

    2015-01-01

    We have previously studied the function of microRNAs (miRNAs) in thyroid cells using the differentiated rat thyroid PC Cl 3 cells that need thyrotropin (TSH) for their growth. The miRNA expression profile examination allowed the detection of a set of miRNAs downregulated and upregulated by TSH. Here, we first demonstrated that upregulation of miR-130b-3p occurs through a protein kinase A-cAMP-responsive element binding protein (CREB)-dependent mechanism. Then, we analyzed its expression in human thyroid follicular adenomas, where a constitutive CREB activation is frequently present. miR-130b-3p results in upregulation with a high fold-change in most thyroid follicular adenomas. Then, we identified CCDC6, coding for a protein that interacts with CREB1 leading to the transcriptional repression of CREB1 target genes, as a target of this miRNA. The targeting of CCDC6 by miR-130b-3p likely accounts for the mechanism by which its upregulation contributes to the development of thyroid adenomas increasing CREB1 activity. PMID:26835423

  14. Theoretical Studies on the Reaction Mechanisms of C3H2 (cyclopropenylidene) and O(3P) Radicals

    XlE Xiaohua; SHEN Wei; HE Rongxing; ZHANG Jinsheng; LI Ming

    2009-01-01

    The complex potential energy surface for the reaction of C3H2 (cyclopropenylidene) with O(3p) was explored computationally using a density functional and ab initio QCISD(T) methods. The geometries of all the stationary points (transition states, intermediates and products) were fully optimized at the B3LYP/6-311++G** computa-tional level, and the single point calculation including full population analysis was performed by employing QCISD(T). Our results show that the product P1 (C2H+HCO) is the major product, while the products P2 (C2H2+ CO) and P3 (HC3O+H) are minor products, as confirmed by experiment. Product P1 could be gained through the path: R→IM1→IM2→P1, and the C3H2+O(3P) reaction was expected to be rapid. So, the C3H2+O(3p) reaction may be an efficient strategy for producing C2H using cyclopropenylidene in atmosphere. The present results can lead us to understand deeply the mechanism of the title reaction.

  15. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model.

    Abraham Lin

    Full Text Available Conjugation is the main mode of horizontal gene transfer that spreads antibiotic resistance among bacteria. Strategies for inhibiting conjugation may be useful for preserving the effectiveness of antibiotics and preventing the emergence of bacterial strains with multiple resistances. Filamentous bacteriophages were first observed to inhibit conjugation several decades ago. Here we investigate the mechanism of inhibition and find that the primary effect on conjugation is occlusion of the conjugative pilus by phage particles. This interaction is mediated primarily by phage coat protein g3p, and exogenous addition of the soluble fragment of g3p inhibited conjugation at low nanomolar concentrations. Our data are quantitatively consistent with a simple model in which association between the pili and phage particles or g3p prevents transmission of an F plasmid encoding tetracycline resistance. We also observe a decrease in the donor ability of infected cells, which is quantitatively consistent with a reduction in pili elaboration. Since many antibiotic-resistance factors confer susceptibility to phage infection through expression of conjugative pili (the receptor for filamentous phage, these results suggest that phage may be a source of soluble proteins that slow the spread of antibiotic resistance genes.

  16. BOT3P: a mesh generation software package for the transport analysis codes Dort, Tort, Twodant, Threedant and MCNP

    Bot3p consists of a set of standard Fortran 77 language programs that gives the users of the deterministic transport codes Dort and Tort some useful diagnostic tools to prepare and check the geometry of their input data files for both Cartesian and cylindrical geometries including graphical display modules. Bot3p produces at the same time the geometrical and material distribution data for the deterministic transport codes Twodant and Threedant and, only in three-dimensional (3D) Cartesian geometry, for the Monte Carlo Transport Code MCNP. This makes it possible to compare directly for the same geometry the effects stemming from the use of different data libraries and solution approaches on transport analysis results. Through the use of Bot3p, radiation transport problems with complex 3D geometrical structures can be modelled easily, as a relatively small amount of engineer-time is required and refinement is achieved by changing few parameters. This tool is useful for solving very large challenging problems. (author)

  17. The MAP3S precipitation chemistry network: Eighth periodic summary report (1984)

    Dana, M.T.

    1987-01-01

    This summary report, the eighth in the series, contains complete field and chemical data from the MAP3S Precipitation Chemistry Network for the year 1984. Sections cover Quality Assurance/Quality Control, network site information, and a brief statistical summary of the 1984 data.

  18. Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid

    Silverman, Richard B; Dewey, Stephen L; Miller, Steven

    2015-03-03

    (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).

  19. Hydrogen Evolution on Supported Incomplete Cubane-type [Mo3S4](4+) Electrocatalysts

    Jaramillo, Thomas; Bonde, Jacob Lindner; Zhang, Jingdong;

    2008-01-01

    Electrocatalytic properties of biomimetic supported incomplete cubane-type [Mo3S4](4+) clusters are investigated. The activity toward the hydrogen evolution reaction (HER) is evaluated on both a high surface area gas diffusion electrode in a membrane electrode assembly and on highly orientated...

  20. High-Purity Fe3S4 Greigite Microcrystals for Magnetic and Electrochemical Performance

    Li, Guowei; Zhang, Baomin; Yu, Feng; Novakova, Alla A.; Krivenkov, Maxim S.; Kiseleva, Tatiana Y.; Chang, Liao; Rao, Jiancun; Polyakov, Alexey O.; Blake, Graeme R.; de Groot, Robert A.; Palstra, Thomas T. M.

    2014-01-01

    High-purity Fe3S4 (greigite) microcrystals with octahedral shape were synthesized via a simple hydrothermal method using a surfactant. The as-prepared samples have the inverse spinel structure with high crystallinity. The saturation magnetization (M-s) reaches 3.74 mu(B) at 5 K and 3.51 mu(B) at roo

  1. Modification of chimeric (2S, 3S)-butanediol dehydrogenase based on structural information.

    Shimegi, Tomohito; Mochizuki, Kaito; Oyama, Takuji; Ohtsuki, Takashi; Kusunoki, Masami; Ui, Sadaharu

    2014-01-01

    A chimeric (2S, 3S)-butanediol dehydrogenase (cLBDH) was engineered to have the strict (S)-configuration specificity of the (2S, 3S)-BDH (BsLBDH) derived from Brevibacterium saccharolyticum as well as the enzymatic stability of the (2R, 3S)-BDH (KpMBDH) from Klebsiella pneumonia by swapping the domains of two native BDHs. However, while cLBDH possesses the stability, it lacks the specificity. In order to assist in the design a BDH having strict substrate specificity, an X-ray structural analysis of a cLBDH crystal was conducted at 1.58 Å. The results obtained show some readily apparent differences around the active sites of cLBDH and BsLBDH. Based on this structural information, a novel (2S, 3S)-BDH having a preferred specificity was developed by introducing a V254L mutation into cLBDH. The influence of this mutation on the stability of cLBDH was not evaluated. Nevertheless, the technique described herein is an effective method for the production of a tailor-made BDH. PMID:25612804

  2. MAP3S precipitation chemistry network: sixth periodic summary report (1982)

    Rothert, J.E.; Dana, M.T.

    1983-07-01

    This report contains complete field and chemical data from the MAP3S Precipitation Chemistry Network for the year 1982. Included is an update on network status and a summary of the USGS blind sample analysis program and laboratory sample exchanges during 1982. The statistical summary is deferred to a forthcoming publication.

  3. Frequency measurements on the 2S-3S transition of lithium-7 and lithium-6

    Sanchez, A. Rodolfo M.; Ewald, Guido; Geppert, Christopher; Kluge, Juergen [GSI mbH, Darmstadt (Germany); Noerterhaeuser, Wilfried [GSI mbH, Darmstadt (Germany)]|[Institut fuer Kernchemie, Universitaet Mainz (Germany); Andjelkovic, Zoran; Kraemer, Joerg; Nothhelfer, Matthias; Tiedemann, Dirk; Zakova, Monika [Institut fuer Kernchemie, Universitaet Mainz (Germany); Winters, Danyal [Institut fuer Kernphysik, Universitaet Muenster (Germany)

    2008-07-01

    We report on the absolute frequency measurement of the 2S-3S two-photon transition of lithium-7 and -6 by employing a frequency comb. The values we obtained in this measurement are a factor ten times better than the last reported ones. We also discuss how a detailed description of the line profile is necessary in order improve the measured values.

  4. Review of future plans of the MAP3S Precipitation Chemistry Network: Derived from a MAP3S workshop held April 18--20, 1989, Bethesda, Maryland

    Wesely, M.L. (Argonne National Lab., IL (USA). Environmental Research Div.); McNaughton, D.J. (ENSR Consulting and Engineering, Glastonbury, CT (USA)); Artz, R.S. (National Oceanic and Atmospheric Administration, Silver Spring, MD (USA). Air Resources Lab.); Gibson, J.H. (National Atmospheric Deposition Program, Fort Collins, CO (USA)); Hansen, D.A. (Electric Power Research Inst., Palo Alto, CA (

    1990-02-01

    A workshop was held in April 1989 to review the future plans of the MAP3S Precipitation Chemistry Network program sponsored by the Department of Energy (DOE). A panel of scientists reviewed options for future activities with regard to meeting the needs of DOE for health and environmental research. The panel concluded that the program should be redirected in the 1990s toward climate change research concerned with the effects of energy-related emissions on the extent of cloud cover and the optical properties of clouds. In addition, the panel found that current operations could be improved, more scientific analysis of the collected data should be conducted, and that the program should be considered as a means of carrying out future research that might be needed to address new health and environmental issues. 37 refs., 5 tabs.

  5. File list: His.PSC.05.H3S10ph.AllCell [Chip-atlas[Archive

    Full Text Available His.PSC.05.H3S10ph.AllCell mm9 Histone H3S10ph Pluripotent stem cell SRX963273,SRX9...63272 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.H3S10ph.AllCell.bed ...

  6. Observation of strong electron correlations in YBa2Cu3O7-δ by hv-dependent photoelectron spectroscopy

    We present photoemission spectra from single-phase YBa2Cu3O7-δ which have been measured in the photon energy range (17(division)130)eV, at T=80 K, T=300 K and intermediate temperatures using synchrotron radiation. Intense satellites associated with the Cu3d and O2p bands are observed to undergo resonances at the Cu3p and O2s core level excitation thresholds, respectively, indicating the presence of holes in the Cu and O hybrid bands on both Cu and O sites. The strong correlation effects for the valence electrons suggest that one-electron calculations may not be appropriate for a detailed description of the electronic properties of this material

  7. Strong decays of χ{sub cJ}(2P) and χ{sub cJ}(3P)

    Wang, Hui; Ping, Jialun [Nanjing Normal University and Jiangsu Key Laboratory for Numerical Simulation of Large Scale Complex Systems, Department of Physics, Nanjing (China); Yang, Youchang [Zunyi Normal College, Department of Physics, Zunyi (China)

    2014-04-15

    In the framework of the chiral quark model, the mass spectrum of χ{sub cJ}(J = 0, 1, 2, n = 1, 2, 3) is studied with the Gaussian expansion method. Using the wave functions obtained in the study of mass spectrum, the open charm two-body strong decay widths of these states are calculated by using the {sup 3}P{sub 0} model. The results show that the masses of χ{sub cJ}(1P) and χ{sub c2}(2P) are consistent with the experimental data. But the strong decay width of χ{sub c2}(2P) is three times that of the experimental value. The decay width of χ{sub c1}(2P) is sensitive to its mass. In the quark-antiquark picture, the width is about 385 MeV. However, if the channel coupling effects shift its mass to 3872 MeV, its decay width will be around 1 MeV. The possibility of assigning the state X(3872) as χ{sub c1}(2P) cannot be excluded. To assign X(3915) as χ{sub c0}(2P) is disfavored, due to the unmatching of decay channel. For the χ{sub cJ}(3P) states, no states have been assigned. The possible candidates of χ{sub c0}(3P) are X(4160) and X(4140). Their masses are close to the theoretical ones. The experimental branching ratio of X(4160), Γ (X(4160) → D anti D)/Γ (X(4160) → D* anti D*) < 0.09 is compatible with that of χ{sub c0}(3P), 0.07. However the broad decay width of X(4160) cannot be explained by the open charm two-body decay. To assign X(4140) as χ{sub c0}(3P) is also possible, due to the compatibility of the total decay width, the further measurement of decay modes of X(4140) are expected to justify the assignment. (orig.)

  8. Ternary Phosphide Ho 2Cu 6- xP 5- y, Its Crystal Structure, and REm+ n(Cu 2P 3) m(Cu 4P 2) n Relationship with Other Rhombohedral Rare-Earth Copper Phosphides

    Mozharivskyj, Yurij; Kuz'ma, Yurij B.

    2000-04-01

    Crystals of the phosphide Ho2Cu6-xP5-y (x=0.41, y=0.50) have been prepared by annealing pressed powders of the elements at 800°C for 2 weeks. The structure was determined by single-crystal methods: space group Roverline3m (No. 166), Z=3, a=3.976(1) Å, c=40.554(8) Å, R=0.045 for 243 independent reflections [F>4σ(F)]. The unit cell of Ho2Cu6-xP5-y can be built from a close packing of Ho atoms and fragments of Cu3P, with one of the fragments containing additional P atoms. It can be also considered as an intercalation of additional P atoms in the YbCu3-xP2 structure (P. Klüfers, A. Mewis, and H. U. Schuster, Z. Kristallogr. 149, 211 (1979)). The REm+n(Cu2P3)m(Cu4P2)n relationship with other rare-earth copper phosphides, having similar structural characteristics is discussed.

  9. Analisa Kadar Unsur Zn Dan Cu Pada Kopi Bubuk (Coffea spp.) Dengan Metode Spektrofotometri Serapan Atom

    Mutiara

    2011-01-01

    The research done on the metal content of Zn and Cu from the coffee powder. Samples analyzed are ground coffee with coffee powder factory industry industrial households are analyzed each week for a month. Measurement of Zn and Cu metal concentrations in ground coffee is done by using basah.Pelarut dekstruksi method used was HNO 3 (p) and H 2 SO 4 (p) and pengoksidasinya H 2 O 2 30% and then analyzed by Atomic Absorption Sepektrofotometer on specific λ = 213.9 nm (Zn) and specific λ = 324.8 ...

  10. Cu vi parolas Esperante?

    Andrzej; Pettyn

    1999-01-01

    LA DEKDUA LECIONOu vi longe atendis min?—Danuta:Saluton,Banjo!—Barbara:Saluton!—D:Cu vi longe atendis min?—B:Tute ne.Mi jus venis i tien.—D:Mi esperas,ke nun vi estas libera.—B:Mi estas tute libera,do ni povas iriien,kien vi deziras.—D:Bone.Mi proponas do,ke unue niiru al magazenoj fari aetojn kaj

  11. Morphology-controllable synthesis of CuO nanostructures and their catalytic activity for the reduction of 4-nitrophenol

    Che, Wei; Ni, Yonghong; Zhang, Yuxing; Ma, Yue

    2015-02-01

    The investigation on the correlation between properties and shapes of nanomaterials always draws increased interest. However, the correlation between properties and shapes of CuO nanostructures was rarely reported in the previous works. The shape-controlled preparation of CuO nanostructures was successfully realized in the present work via a simple oil-bath route in air at 170 °;C for 30 min, employing CuCl2•2H2O and NaOH as the reactants. It was found that CuO nanocrystals with leaf-like, dumbbell-like and flowerlike structures were obtained through introducing various additives. At the same time, the correlation between properties and shapes was investigated. It was found that the catalytic performances of the as-prepared CuO nanostructures for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in NaBH4 aqueous solution were dependent on its morphologies. Experiments showed that the first-order rate constants for CuO nanostructures with various shapes were in turn 35.5‧ 10-3 s-1 (leaf-like nanosheets), 4.77‧ 10-3 s-1 (dumbbell-like architectures), 10.6‧ 10-3 s-1 (flowerlike nanostructures). The present research provides a new catalyst selection for the reduction of 4-NP to 4-AP in excess NaBH4 aqueous solution, which has potential application in industrial production.

  12. Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5'-Monophosphate (AMP)-activated Protein Kinase α1.

    Meng, Xiangyu; Guo, Jun; Fang, Weiwei; Dou, Lin; Li, Meng; Huang, Xiuqing; Zhou, Shutong; Man, Yong; Tang, Weiqing; Yu, Liqing; Li, Jian

    2016-05-13

    In a microarray study, we found that hepatic miR-291b-3p was significantly increased in leptin-receptor-deficient type 2 mice (db/db), a mouse model of diabetes. The function of miR-291b-3p is unknown. The potential role of miR-291b-3p in regulating hepatic lipid metabolism was explored in this study. High-fat diet (HFD)- and chow-fed mice were injected with an adenovirus expressing a miR-291b-3p inhibitor and a miR-291b-3p mimic through the tail vein. Hepatic lipids and lipogenic gene expression were analyzed. Additionally, gain- and loss-of-function studies were performed in vitro to identify direct targets of miR-291b-3p. MiR-291b-3p expression and the protein levels of sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FAS) were increased in the steatotic liver of db/db mice and HFD-fed mice versus their respective controls. Inhibition of hepatic miR-291b-3p expression prevented increases in hepatic lipogenesis and steatosis in HFD-fed mice. The opposite was observed when miR-291b-3p was overexpressed in the livers of chow-fed C57BL/6J wild-type mice. In vitro studies revealed that silencing of miR-291b-3p in NCTC1469 hepatic cells ameliorated oleic acid/palmitic acid mixture-induced elevation of cellular triglycerides. Importantly, we identified AMP-activated protein kinase (AMPK)-α1 as a direct target of miR-291b-3p. Using metformin, an activator of AMPK, we showed that AMPK activation-induced inhibition of hepatic lipid accumulation was accompanied by reduced expression of miR-291b-3p in the liver. Liver miR-291b-3p promoted hepatic lipogenesis and lipid accumulation in mice. AMPKα1 is a direct target of miR-291b-3p. In conclusion, our findings indicate that miR-291b-3p promotes hepatic lipogenesis by suppressing AMPKα1 expression and activity, indicating the therapeutic potential of miR-291b-3p inhibitors in fatty liver disease. PMID:27013659

  13. WAVELENGTHS OF THE 3p-3d TRANSITIONS OF THE Co- AND Fe-LIKE IONS : THE EFFECTS OF ELECTRON CORRELATION

    Chen, M.

    1988-01-01

    The experimental observations of the 3p6 3d9 2D - 3p5 3dl0 2p transitions of the Co-like ions and 3p6 3d8 3F4 - 3p5 3d9 3F3 of the Fe-like ions have recently been extended to highly charged ions of heavy elements up to uranium (Z = 92). A comparison between the observed energies and calculated values from the Dirac-Fock model indicated persistent diicrepancies of 3-4 eV for al1 ions. Systematic multiconfiguration Dirac-Fock caiculations for these transitions have been carried out with emphasi...

  14. Additional investigations of silicon phosphides (SiP and Si3P2) at phosphor-diffused silicon wafers

    Results were obtained by X-ray microanalysis and neutron activation analysis. The formation of the Si3P2-phase (circular particles of about 15 μm in diameter) takes place on polished silicon slices during the phosphorus diffusion both in N2-O2-POCl3 carrier gas and in O2-P2O5 carrier gas. In this case the average phosphorus concentration in phosphorus glass sheet (reaction phase, i.e. SiO2-P2O5-phase) is greater than the limit value being placed in the interval c1 = (8,30 ... 9,44) mass-percent phosphorus for a temperature T = 1523 K (12500C). The surface concentration of phosphorus in silicon between the Si3P2-particles being formed on slices does not depend on the phosphorus concentration in the carrier gas. This constant concentration value is identical with the solid solubility limit for phosphorus in silicon, measured for C/sub F/ = 1.29 x 1021 P-atoms/cm3, resp. c/sub F/ = 2.72 mass percent. On the other hand the phosphorus concentration is C/sub G/ = 9.2 x 1020 P-atoms/cm3 in the interior of the diffused layer in silicon directly beside the Si3P2-particle. The formation of the SiP-phase was observed on lapped silicon slices for phosphorus diffusion in wet N2-O2-POCl3 carrier gas at a temperature T = 1523 K (12500C). (author)

  15. The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.

    Du, William W; Li, Xianmin; Li, Tianbi; Li, Haoran; Khorshidi, Azam; Liu, Fengqiong; Yang, Burton B

    2015-01-15

    The microRNA miR-17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We examined the roles of miR-17 in senescence and demonstrated that miR-17-3p attenuates cardiac aging in the myocardium by targeting Par4 (also known as PAWR). This upregulates the downstream proteins CEBPB, FAK, N-cadherin, vimentin, Oct4 and Sca-1 (also known as stem cell antigen-1), and downregulates E-cadherin. Par4 has been reported as a tumor suppressor gene that induces apoptosis in cancer cells, but not in normal cells. Repression of Par4 by miR-17-3p enhances the transcription of CEBPB and FAK, which promotes mouse cardiac fibroblast (MCF) epithelial-to-mesenchymal transition (EMT) and self-renewal, resulting in cellular senescence and apoptosis resistance. We conclude that Par4 can bind to the CEBPB promoter and inhibit its transcription. Decreased Par4 expression increases the amount of CEBPB, which binds to the FAK promoter and enhances FAK transcription. Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal. Through this novel senescence signaling axis, miR-17-3p represses Par4 expression, acting pleiotropically as a negative modulator of cardiac aging and cardiac fibroblast cellular senescence. PMID:25472717

  16. Internationally Recommended Best Practices in Transportation Financing Public-Private Partnerships (P3s)

    Martin, Lawrence; Lawther, Wendell; Hodge, Graeme;

    2013-01-01

    internationally recommended best practices in transportation financing P3s. Based upon the study findings, a checklist in then proposed that can be used by U.S. state and local governments to assess their current or proposed transportation financing P3 policies and procedures. The article makes a contribution to...... the literature on transportation financing P3s by bringing together for the first time internationally recommended best practices in ten major areas....... sector partner designs-builds-finances-operates- maintains (DBFOM) a transportation infrastructure asset (road, highway, bridge, tunnel, etc.) with an emphasis on financing. Under this type of arrangement, the private sector partner is primarily responsible for securing all or substantially all of the...

  17. Synthetic Ni3S2/Ni hybrid architectures as potential contrast agents in MRI

    Ma, J.; Chen, K.

    2016-04-01

    Traditional magnetic resonance imaging (MRI) contrast agents mainly include superparamagnetic (SPM) iron oxide nanoparticle as T 2 contrast agent for liver and paramagnetic Gd (III)-chelate as T 1 contrast agent for all organs. In this work, weak ferromagnetic kale-like and SPM cabbage-like Ni3S2@Ni hybrid architectures were synthesized and evaluated as potential T 1 MRI contrast agents. Their relatively small r 2/r 1 ratios of 2.59 and 2.38, and high r 1 values of 11.27 and 4.89 mmol‑1 L s‑1 (for the kale-like and cabbage-like Ni3S2@Ni, respectively) will shed some light on the development of new-type MRI contrast agents.

  18. Ionisation from the 3s sub-level of highly charged ions

    Golden, L. B.; Sampson, D. H.; Omidvar, K.

    1978-01-01

    Scaled electron-impact cross sections are calculated for ionization from the 3s sublevel of hydrogenic ions with Z equal infinity by use of the Born exchange or the Coulomb-Born Oppenheimer approximation (which is exact, apart from relativistic corrections, in this limit). The results are fitted to an analytic expression which goes into the correct Bethe approximation result at high energies and which can readily be integrated over a Maxwellian electron velocity distribution to obtain collision rates. These results permit calculation of the approximate cross section and collision rate for ionization from the 3s sublevel of any highly charged ion with Z/N larger than approximately 2. Results obtained by the described procedure for Fe-14(+) and Fe-15(+) are compared with results obtained by other procedures.

  19. Evidence for a heated gas bubble inside the "cooling flow" region of MKW3s

    Mazzotta, P; Paerels, F B S; Ferrigno, C; Colafrancesco, Sergio; Mewe, R; Forman, W R

    2002-01-01

    We report on the deep Chandra observation of central r=200kpc region of the cluster of galaxies MKW3s which was previously identified as a moderate cooling flow cluster. The Chandra image reveals two striking features -- a 100kpc long and 21kpc wide filament, extending from the center to the south-west and a nearly circular, 50kpc diameter depression 90 kpc south of the X-ray peak. The temperature map shows that the filamentary structure is colder while the surface brightness depression is hotter than the average cluster temperature at any radius. The hot and the cold regions indicate that both cooling and heating processes are taking place in the center of MKW3s. We argue that the surface brightness depression is produced by a heated, low-density gas bubble along the line of sight. We suggest that the heated bubble is produced by short-lived nuclear outbursts from the central galaxy.

  20. A free surface algorithm in the N3S finite element code for turbulent flows

    In this paper, we present a free surface algorithm which was implemented in the N3S code. Free surfaces are represented by marker particles which move through a mesh. It is assumed that the free surface is located inside each element that contains markers and surrounded by at least one element with no marker inside. The mesh is then locally adjusted in order to coincide with the free surface which is well defined by the forefront marker particles. After describing the governing equations and the N3S solving methods, we present the free surface algorithm. Results obtained for two-dimensional and three-dimensional industrial problems of mould filling are presented. (authors). 5 refs., 2 figs

  1. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance

    Szczesny, Roman J; Borowski, Lukasz S.; Brzezniak, Lien K.; Dmochowska, Aleksandra; Gewartowski, Kamil; Bartnik, Ewa; Stepien, Piotr P.

    2009-01-01

    The mechanism of human mitochondrial RNA turnover and surveillance is still a matter of debate. We have obtained a cellular model for studying the role of hSuv3p helicase in human mitochondria. Expression of a dominant-negative mutant of the hSUV3 gene which encodes a protein with no ATPase or helicase activity results in perturbations of mtRNA metabolism and enables to study the processing and degradation intermediates which otherwise are difficult to detect because of their short half-lives...

  2. Two-photon ionisation of metastable helium: complex structure in the 2S-3P resonance profiles

    The wavelength dependence of resonant two-photon ionisation of metastable helium via the 3P intermediate level is reported. In both the singlet and triplet systems an additional complex, but reproducible, structure is seen in the resonance profile of the ion signal. This occurs for moderate laser intensities strong enough to saturate the resonant transition. The physical reason for the structure is not understood, but measurements point to a delicate dependence on the time development of the atomic states and the laser pulse. (author)

  3. Fum3p, a 2-Ketoglutarate-Dependent Dioxygenase Required for C-5 Hydroxylation of Fumonisins in Fusarium verticillioides

    Ding, Yousong; Bojja, Ravi S.; Du, Liangcheng

    2004-01-01

    Fumonisins are polyketide-derived mycotoxins produced by several agriculturally important Fusarium species. The B series fumonisins, FB1, FB2, FB3, and FB4, are fumonisins produced by wild-type Fusarium verticillioides strains, differing in the number and location of hydroxyl groups attached to the carbon backbone. We characterized the protein encoded by FUM3, a gene in the fumonisin biosynthetic gene cluster. The 33-kDa FUM3 protein (Fum3p) was heterologously expressed and purified from Sacc...

  4. Remote frequency measurement of the 1S0-3P1 transition in laser cooled Mg-24

    Friebe, J.; Riedmann, M.; Wübbena, T.; Pape, A.; Kelkar, H.; Ertmer, W.; Terra, O.; Sterr, U.; Weyers, S.; Grosche, G.; Schnatz, H.; Rasel, E. M.

    2011-01-01

    We perform Ramsey-Bord\\'e spectroscopy on laser-cooled magnesium atoms in free fall to measure the 1S0 \\rightarrow 3P1 intercombination transition frequency. The measured value of 655 659 923 839 730 (48) Hz is consistent with our former atomic beam measurement (Friebe et al 2008 Phys. Rev. A 78 033830). We improve upon the fractional accuracy of the previous measurement by more than an order of magnitude to 7e-14. The magnesium frequency standard was referenced to a fountain clock of the Phy...

  5. Formation of deeply bound ultracold Sr_2 molecules by photoassociation near the ^1S + ^3P_1 intercombination line

    Skomorowski, Wojciech; Moszynski, Robert; Koch, Christiane P.

    2012-01-01

    We predict feasibility of the photoassociative formation of Sr_2 molecules in arbitrary vibrational levels of the electronic ground state based on state-of-the-art ab initio calculations. Key is the strong spin-orbit interaction between the c^3\\Pi_u, A^1\\Sigma_u^+ and B^1\\Sigma_u^+ states. It creates not only an effective dipole moment allowing free-to-bound transitions near the ^1S + ^3P_1 intercombination line but also facilitates bound-to-bound transitions via resonantly coupled excited st...

  6. Polarization Measurements of the Resonant Multiphoton Ionization Spectrum of the 3 s Rydberg States of Monomethylpyridines

    Kosmidis, C.; Bolovinos, A.; Tsekeris, P.

    1993-07-01

    The circular to linear polarization ratio for the two-photon excitation of the 3 s Rydberg states of monomethylpyridines has been measured by 2 + 1 resonant MPI spectroscopy in a static cell. The symmetry of the Rydberg vibrational bands is deduced and the results from the 0-0 transition suggest that the highest occupied MO of 4-methylpyridine is an n MO, while that for 2- and 3-methylpyridines is a π-type one.

  7. Ef3S: An evaluation framework for flash-based systems

    Galfano, Salvatore; Di Carlo, Stefano; Indaco, Marco; Prinetto, Paolo Ernesto

    2013-01-01

    NAND Flash memories are gaining popularity in the development of electronic embedded systems for both consumer and mission-critical applications. NAND Flashes crucially influence computing systems development and performances. EF3S, a framework to easily assess NAND Flash based memory systems performances (reliability, throughput, power), is presented. The framework is based on a simulation engine and a running environment which enable developers to assess any application impact. Experimental...

  8. Total synthesis of (3S, 5R, 3'S, 5'R)-capsorubin

    Frederico, Daniel; Constantino, Mauricio G.; Donate, Paulo M. [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras. Dept. de Quimica

    2009-07-01

    The total synthesis of enantiomerically enriched (3S, 5R, 3'S, 5'R)-capsorubin (1) by aldol condensation of (1R, 4S)-1-(4-hydroxy-1,2,2-trimethyl-cyclopentyl)ethanone (2a) and crocetindial (3) is described. An alternative, short eight-step synthesis of the optically active compound 2a (ee 89%) is also reported. (author)

  9. Magnetic properties of sedimentary greigite (Fe3S4): an update

    Roberts, A. P.; Research School of Earth Sciences, Australian National University, Canberra, ACT, Australia; Chang, L.; National Oceanography Centre, Southampton, University of Southampton, Southampton, UK; Rowan, C. J.; School of GeoSciences, University of Edinburgh, Edinburgh, UK; Horng, C.; Institute of Earth Sciences, Academia Sinica, Taipei, Taiwan; Florindo, F.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma2, Roma, Italia

    2010-01-01

    Greigite (Fe3S4) is an authigenic ferrimagnetic mineral that grows as a precursor to pyrite during early diagenetic sedimentary sulfate reduction. It can also grow at any time when dissolved iron and sulfide are available during diagenesis. Greigite is important in paleomagnetic, environmental, biological, biogeochemical, tectonic, and industrial processes. Much recent progress has been made in understanding its magnetic properties. Greigite is an inverse spinel and a collinear ferrimagnet...

  10. Catalytic water dissociation by greigite Fe3S4 surfaces: density functional theory study

    Roldan, A.; de Leeuw, N. H.

    2016-01-01

    The iron sulfide mineral greigite, Fe3S4, has shown promising capability as a hydrogenating catalyst, in particular in the reduction of carbon dioxide to produce small organic molecules under mild conditions. We employed density functional theory calculations to investigate the {001},{011} and {111} surfaces of this iron thiospinel material, as well as the production of hydrogen ad-atoms from the dissociation of water molecules on the surfaces. We systematically analysed the adsorption geomet...

  11. Magnetic properties of sedimentary greigite (Fe3S4): an update

    Roberts, A. P.; National Oceanography Centre, University of Southampton, Southampton, UK.; Chang, L.; National Oceanography Centre, Southampton, University of Southampton, Southampton, UK; Rowan, C. J.; National Oceanography Centre, Southampton, University of Southampton, Southampton, UK and Now at School of GeoSciences, University of Edinburgh, Edinburgh, UK; Horng, C.‐S.; Institute of Earth Sciences, Academia Sinica, Taipei, Taiwan; Florindo, F.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma2, Roma, Italia

    2011-01-01

    Greigite (Fe3S4) is an authigenic ferrimagnetic mineral that grows as a precursor to pyrite during early diagenetic sedimentary sulfate reduction. It can also grow at any time when dissolved iron and sulfide are available during diagenesis. Greigite is important in paleomagnetic, environmental, biological, biogeochemical, tectonic, and industrial processes. Much recent progress has been made in understanding its magnetic properties. Greigite is an inverse spinel and a col...

  12. Risk-informed approach for safety, safeguards, and security (3S) by design

    Over several decades the nuclear energy society worldwide has developed safety assessment methodology based on probabilistic risk analysis for incorporating its benefit into design and accident prevention for nuclear reactors. Although safeguards and security communities have different histories and technical aspects compared to safety, risk assessment as a supplement to their current requirements could be developed to promote synergism between Safety, Safeguards, and Security (3S) and to install effective countermeasures in the design of complex nuclear fuel cycle facilities. Since the 3S initiative was raised by G8 countries at Hokkaido Toyako-Summit in 2008, one approach to developing synergism in a 3S By Design (3SBD) process has been the application of risk-oriented assessment methodology. In the existing regulations of safeguards and security, a risk notion has already been considered for inherent threat and hazard recognition. To integrate existing metrics into a risk-oriented approach, several mathematical methods have already been surveyed, with attention to the scarcity of intentional acts in the case of safeguards and the sparseness of actual event data. A two-dimensional probability distribution composed of measurement error and incidence probabilities has been proposed to formalize inherent difficulties in the International Atomic Energy Agency (IAEA) safeguards criteria. In particular, the incidence probability that is difficult to estimate has been explained using a Markov model and game theory. In this work, a feasibility study of 3SBD is performed for an aqueous reprocessing process, and synergetic countermeasures are presented for preliminary demonstration of 3SBD. Although differences and conflicts between individual 'S' communities exist, the integrated approach would be valuable for optimization and balance between the 3S design features as well as for effective and efficient implementation under existing regulation frameworks. In addition

  13. Van Hove singularities and spectral smearing in high-temperature superconducting H3S

    Quan, Yundi; Pickett, Warren E.

    2016-03-01

    The superconducting phase of hydrogen sulfide at Tc=200 K observed by Drozdov and collaborators at pressures around 200 GPa is simple bcc I m 3 ¯m H3S from a combination of theoretical and experimental confirmation. The various "extremes" that are involved—high pressure implying extreme reduction of volume, extremely high H phonon energy scale around 1400 K, extremely high temperature for a superconductor—necessitates a close look at new issues raised by these characteristics in relation to high Tc itself. First principles methods are applied to analyze the H3S electronic structure, beginning with the effect of sulfur and then focusing on the origin and implications of the two van Hove singularities (vHs) providing an impressive peak in the density of states near the Fermi energy. Implications arising from strong coupling Migdal-Eliashberg theory are studied. It becomes evident that electron spectral density smearing due to virtual phonon emission and absorption must be accounted for in a correct understanding of this unusual material and to obtain accurate theoretical predictions. Means for increasing Tc in H3S -like materials are noted.

  14. Participation of the Pennsylvania State University in the MAP3S precipitation chemistry network

    The Meteorology Department of the Pennsylvania State University collected precipitation in central Pennsylvania for more than 14 years on behalf of the Multistate Atmospheric Power Production Pollution Study (MAP3S). The MAP3S protocol, based on the sampling of precipitation from individual meteorological events over a long period of time, has allowed both for the development of a chemical climatology of precipitation in the eastern region of the United States and for a vastly improved understanding of the atmospheric processes responsible for wet acidic deposition. The precipitation chemistry data from the Penn State MAP3S site provide evidence of links to the anthropogenic emissions of sulfur dioxide and oxidant precursors. There is now little doubt that the free acidity in the precipitation of the region is due to the presence of unneutralized sulfate in the aqueous phase. In the absence of significant sources of this sulfur species and in view of supplemental enrichment studies, it is concluded that the sulfate enters cloud and rain water primarily through the aqueous-phase oxidation of sulfur dioxide emitted into the air within the geographical region of deposition. Within the source region the local abundances of sulfur dioxide often exceed those of the oxidants, so the depositions of sulfate and free acidity tend to be modulated by the availability of the strong oxidants. As a consequence, the deposition of sulfate exhibits a very strong seasonal dependence and little response to changes in the emissions of sulfur dioxide

  15. The crystal structure of novel silver sulphogermanate Ag10Ge3S11

    Highlights: •Ag10Ge3S11 single crystal was synthesized. •The crystal structure was studied in detail by X-ray diffraction. •The structure is a packing of twin [Ge2S7]6− and single tetrahedra [GeS4]4-. •The studied crystal has potential applications as photoinduced materials. -- Abstract: The Ag10Ge3S11 compound was synthesized by melting the calculated amounts of elements in evacuated quartz ampoules at 1170 K. The crystal structure of the compound was determined by the single crystal technique; it is a representative of its own structural type. The compound crystallizes in a non-centrosymmetric space group Cc with unit cell parameters a = 2.6244(4), b = 0.65020(5), c = 2.5083(4) nm, β = 109.910(1)°. The Ag10Ge3S11 structure may be described as a packing of the fragments composed of two twin [Ge2S7]6− and two single tetrahedra [GeS4]4−. The Ag atoms are situated in the tunnels formed by these fragments. The relationship with the similar structures is discussed

  16. BOREAS Level-3s SPOT Imagery: Scaled At-sensor Radiance in LGSOWG Format

    Strub, Richard; Nickeson, Jaime; Newcomer, Jeffrey A.; Hall, Forrest G. (Editor); Cihlar, Josef

    2000-01-01

    For BOReal Ecosystem-Atmosphere Study (BOREAS), the level-3s Satellite Pour l'Observation de la Terre (SPOT) data, along with the other remotely sensed images, were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy, detailed land cover, and biophysical parameter maps such as Fraction of Photosynthetically Active Radiation (FPAR) and Leaf Area Index (LAI). The SPOT images acquired for the BOREAS project were selected primarily to fill temporal gaps in the Landsat Thematic Mapper (TM) image data collection. CCRS collected and supplied the level-3s images to BOREAS Information System (BORIS) for use in the remote sensing research activities. Spatially, the level-3s images cover 60- by 60-km portions of the BOREAS Northern Study Area (NSA) and Southern Study Area (SSA). Temporally, the images cover the period of 17-Apr-1994 to 30-Aug-1996. The images are available in binary image format files. Due to copyright issues, the SPOT images may not be publicly available.

  17. Heated Intracluster Gas and Radio Connections: the Singular case of MKW3s

    Mazzotta, P; Giacintucci, S; Venturi, T; Bardelli, S; Mazzotta, Pasquale; Brunetti, Gianfranco; Giacintucci, Simona; Venturi, Tiziana; Bardelli, Sandro

    2004-01-01

    Similarly to other cluster of galaxies previously classified as cooling flow systems, the Chandra observation of MKW3s reveals that this object has a complex X-ray structure hosting both a X-ray cavity and a X-ray filament. Unlike the other clusters, however, the temperature map of the core of MKW3s shows the presence of extended regions of gas heated above the radially averaged gas temperature at any radius. As the cluster does not show evidences for ongoing major mergers Mazzotta et al. suggest a connection between the heated gas and the activity of the central AGN. Nevertheless, due to the lack of high quality radio maps, this interpretation was controversial. In this paper we present the results of two new radio observations of MKW3s at 1.28GHz and 604MHz obtained at the GMRT. Together with the Chandra observation and a separate VLA observation at 327MHz from Young, we show unequivocal evidences for a close connection between the heated gas region and the AGN activity and we briefly summarize possible imp...

  18. Magnetic Moment of $^{59}$Cu

    2002-01-01

    Experiment IS358 uses the intense and pure beams of copper isotopes provided by the ISOLDE RILIS (resonance ionization laser ion source). The isotopes are implanted and oriented in the low temperature nuclear orientation set-up NICOLE. Magnetic moments are measured by $\\beta$-NMR. Copper (Z=29), with a single proton above the proton-magic nickel isotopes provides an ideal testground for precise shell model calculations of magnetic moments and their experimental verification. In the course of our experiments we already determined the magnetic moments of $^{67}$Ni, $^{67}$Cu, $^{68g}$Cu, $^{69}$Cu and $^{71}$Cu which provide important information on the magicity of the N=40 subshell closure. In 2001 we plan to conclude our systematic investigations by measuring the magnetic moment of the neutron-deficient isotope $^{59}$Cu. This will pave the way for a subsequent study of the magnetic moment of $^{57}$Cu with a complementary method.

  19. Effect of CuO on the Formation Mechanism of Calcium Sulphoaluminate

    MA Suhua; SHEN Xiaohong; HUANG Yeping; ZHONG Baiqian

    2008-01-01

    Calcium sulphoaluminate was prepared with chemical reagents in this paper.The formation mechanism of calcium sulphoaluminate and effect of CuO on the formation mechanism of calcium sulphoaluminate were investigated by the chemical analysis,X-ray diffraction(XRD),and differential scanning calorimetry(DSC).The results show that there are three ways in the formation of calcium sulphoaluminate.CuO can promote the decomposition of calcium carbonate and decrease the formation temperature of calcium sulphoaluminate(C4A3S).When the burning temperature is below 1000℃,the addition of CuO can promote the formation of calcium sulphoaluminate,while CuO can not favor the formation of calcium sulphoaluminate above 1000℃.

  20. A Mild One-Step Solvothermal Route to Metal Phosphides (Metal=Co, Ni, Cu)

    Xie, Y.; Su, H. L.; Qian, X. F.; Liu, X. M.; Qian, Y. T.

    2000-01-01

    Nanocrystalline Co2P, Ni2P, and Cu3P were successfully prepared through a simple solvothermal process based on the direct reactions of metal halides with yellow phosphorus at rather mild temperatures (80-140°C) with ethylenediamine used as the solvent. XRD, XPS, and TEM were used to study the phases, compositions, and morphologies of the final products. A possible mechanism is proposed and the influential factors in the process are discussed in detail.

  1. Effect of Van Hove singularities on high-Tc superconductivity in H3S

    Sano, Wataru; Koretsune, Takashi; Tadano, Terumasa; Akashi, Ryosuke; Arita, Ryotaro

    2016-03-01

    One of the interesting open questions for the high-transition-temperature (Tc) superconductivity in sulfur hydrides is why high-pressure phases of H3S have extremely high Tc's. Recently, it has been pointed out that the presence of the Van Hove singularities (VHS) around the Fermi level is crucial. However, while there have been quantitative estimates of Tc based on the Migdal-Eliashberg theory, the energy dependence of the density of states (DOS) has been neglected to simplify the Eliashberg equation. In this study, we go beyond the constant DOS approximation and explicitly consider the electronic structure over 40 eV around the Fermi level. In contrast with the previous conventional calculations, this approach with a sufficiently large number of Matsubara frequencies enables us to calculate Tc without introducing the empirical pseudo Coulomb potential. We show that while H3S has much higher Tc than H2S for which the VHS is absent, the constant DOS approximation employed so far seriously overestimates (underestimates) Tc by ˜60 K (˜10 K) for H3S (H2S ). We then discuss the impact of the strong electron-phonon coupling on the electronic structure with and without the VHS and how it affects the superconductivity. In particular, we focus on (1) the feedback effect in the self-consistent calculation of the self-energy, (2) the effect of the energy shift due to the zero-point motion, and (3) the effect of the changes in the phonon frequencies due to strong anharmonicity. We show that the effect of (1)-(3) on Tc is about 10-30 K for both H3S and H2S . Eventually, Tc is estimated to be 181 K for H3S at 250 GPa and 34 K for H2S at 140 GPa, which explains the pressure dependence of Tc observed in the experiment. In addition, we evaluate the lowest-order vertex correction beyond the Migdal-Eliashberg theory and discuss the validity of the Migdal approximation for sulfur hydrides.

  2. Cu2O-based solar cells using oxide semiconductors

    Minami, Tadatsugu; Nishi, Yuki; Miyata, Toshihiro

    2016-01-01

    We describe significant improvements of the photovoltaic properties that were achieved in Al-doped ZnO (AZO)/n-type oxide semiconductor/p-type Cu2O heterojunction solar cells fabricated using p-type Cu2O sheets prepared by thermally oxidizing Cu sheets. The multicomponent oxide thin film used as the n-type semiconductor layer was prepared with various chemical compositions on non-intentionally heated Cu2O sheets under various deposition conditions using a pulsed laser deposition method. In Cu2O-based heterojunction solar cells fabricated using various ternary compounds as the n-type oxide thin-film layer, the best photovoltaic performance was obtained with an n-ZnGa2O4 thin-film layer. In most of the Cu2O-based heterojunction solar cells using multicomponent oxides composed of combinations of various binary compounds, the obtained photovoltaic properties changed gradually as the chemical composition was varied. However, with the ZnO-MgO and Ga2O3-Al2O3 systems, higher conversion efficiencies (η) as well as a high open circuit voltage (Voc) were obtained by using a relatively small amount of MgO or Al2O3, e.g., (ZnO)0.91-(MgO)0.09 and (Ga2O3)0.975-(Al2O3)0.025, respectively. When Cu2O-based heterojunction solar cells were fabricated using Al2O3-Ga2O3-MgO-ZnO (AGMZO) multicomponent oxide thin films deposited with metal atomic ratios of 10, 60, 10 and 20 at.% for the Al, Ga, Mg and Zn, respectively, a high Voc of 0.98 V and an η of 4.82% were obtained. In addition, an enhanced η and an improved fill factor could be achieved in AZO/n-type multicomponent oxide/p-type Cu2O heterojunction solar cells fabricated using Na-doped Cu2O (Cu2O:Na) sheets that featured a resistivity controlled by optimizing the post-annealing temperature and duration. Consequently, an η of 6.25% and a Voc of 0.84 V were obtained in a MgF2/AZO/n-(Ga2O3-Al2O3)/p-Cu2O:Na heterojunction solar cell fabricated using a Cu2O:Na sheet with a resistivity of approximately 10 Ω·cm and a (Ga0.975Al0

  3. Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast

    García-Rodríguez, Luis J.; Gay, Anna Card; Pon, Liza A.

    2007-01-01

    Puf3p binds preferentially to messenger RNAs (mRNAs) for nuclear-encoded mitochondrial proteins. We find that Puf3p localizes to the cytosolic face of the mitochondrial outer membrane. Overexpression of PUF3 results in reduced mitochondrial respiratory activity and reduced levels of Pet123p, a protein encoded by a Puf3p-binding mRNA. Puf3p levels are reduced during the diauxic shift and growth on a nonfermentable carbon source, conditions that stimulate mitochondrial biogenesis. These findings support a role for Puf3p in mitochondrial biogenesis through effects on mRNA interactions. In addition, Puf3p links the mitochore, a complex required for mitochondrial–cytoskeletal interactions, to the Arp2/3 complex, the force generator for actin-dependent, bud-directed mitochondrial movement. Puf3p, the mitochore, and the Arp2/3 complex coimmunoprecipitate and have two-hybrid interactions. Moreover, deletion of PUF3 results in reduced interaction between the mitochore and the Arp2/3 complex and defects in mitochondrial morphology and motility similar to those observed in Arp2/3 complex mutants. Thus, Puf3p is a mitochondrial protein that contributes to the biogenesis and motility of the organelle. PMID:17210948

  4. 2s 2p 3P10 → 2s21S0 intercombination line in beryllium-like krypton, molybdenum and tungsten

    Transition probabilities are evaluated for the 2s 2p 3P10 → 2s21S0 transition in beryllium-like ions for krypton, molybdenum and tungsten, using configuration-interaction wavefunctions. The importance of the 2s 3p 1P10 configuration is considered

  5. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells

    Rasmussen, Mads Heilskov; Lyskjær, Iben; Jersie-Christensen, Rosa Rakownikow;

    2016-01-01

    Oxaliplatin resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Herein, we show that miR-625-3p functionally induces oxaliplatin resistance in CRC cells, and identify the...

  6. MiR-291b-3p Induces Apoptosis in Liver Cell Line NCTC1469 by Reducing the Level of RNA-binding Protein HuR

    Jun Guo

    2014-03-01

    Full Text Available Background: There is increasing evidence that miRNAs are involved in cellular apoptosis. However, the specific role of miR-291b-3p in apoptosis has not been elucidated. In the present study, we investigated the effect of miR-291b-3p on NCTC1469 cell growth and apoptosis. Methods: Cell viability and apoptosis were examined in NCTC1469 cells transfected with miR-291b-3p mimics, inhibitor miRNA or negative control. Using computational miRNA target prediction databases, HuR was predicted as a target of miR-291b-3p. Luciferase assay, immunofluorescence and western blot were used to further explore the effects of miR-291b-3p on HuR expression. In addition, the effect of HuR on cell apoptosis was evaluated using a HuR-specific siRNA. Results: TNF-α-induced hepatocyte apoptosis was accompanied by enhanced expression of miR-291b-3p, suggesting that miR-291b-3p might contribute to the apoptotic process. Follow-up experiments showed that upregulation of miR-291b-3p decreased cell viability and induced NCTC1469 cell apoptosis. Additionally, similar to the activity of miR-519, which is another member of the same miRNA family, miR-291b-3p suppressed HuR translation through binding to the HuR coding region (CR. We further showed that the downregulation of HuR expression by miR-291b-3p was accompanied by reduced Bcl-2 expression. Moreover, knockdown of HuR also impaired Bcl-2 expression and increased the ratio of Bax/Bcl-2. More significantly, downregulation of miR-291b-3p failed to increase Bcl2 expression in NCTC1469 cells that were co-transfected with siRNA-HuR. Finally, inhibition of miR-291b-3p led to reduced apoptosis, while knockdown of HuR by siRNA promoted apoptosis, even in NCTC1469 cells that were co-transfected with the miR-291b-3p inhibitor. Conclusion: The current data suggested that miR-291b-3p contributed to NCTC1469 cell apoptosis by regulating the expression of HuR, which in turn increased Bcl-2 stability.

  7. A ternary Cu2O-Cu-CuO nanocomposite: a catalyst with intriguing activity.

    Sasmal, Anup Kumar; Dutta, Soumen; Pal, Tarasankar

    2016-02-21

    In this work, the syntheses of Cu2O as well as Cu(0) nanoparticle catalysts are presented. Copper acetate monohydrate produced two distinctly different catalyst particles with varying concentrations of hydrazine hydrate at room temperature without using any surfactant or support. Then both of them were employed separately for 4-nitrophenol reduction in aqueous solution in the presence of sodium borohydride at room temperature. To our surprise, it was noticed that the catalytic activity of Cu2O was much higher than that of the metal Cu(0) nanoparticles. We have confirmed the reason for the exceptionally high catalytic activity of cuprous oxide nanoparticles over other noble metal nanoparticles for 4-nitrophenol reduction. A plausible mechanism has been reported. The unusual activity of Cu2O nanoparticles in the reduction reaction has been observed because of the in situ generated ternary nanocomposite, Cu2O-Cu-CuO, which rapidly relays electrons and acts as a better catalyst. In this ternary composite, highly active in situ generated Cu(0) is proved to be responsible for the hydride transfer reaction. The mechanism of 4-nitrophenol reduction has been established from supporting TEM studies. To further support our proposition, we have prepared a compositionally similar Cu2O-Cu-CuO nanocomposite using Cu2O and sodium borohydride which however displayed lower rate of reduction than that of the in situ produced ternary nanocomposite. The evolution of isolated Cu(0) nanoparticles for 4-nitrophenol reduction from Cu2O under surfactant-free condition has also been taken into consideration. The synthetic procedures of cuprous oxide as well as its catalytic activity in the reduction of 4-nitrophenol are very convenient, fast, cost-effective, and easily operable in aqueous medium and were followed spectrophotometrically. Additionally, the Cu2O-catalyzed 4-nitrophenol reduction methodology was extended further to the reduction of electronically diverse nitroarenes. This

  8. Unravelling the composition of the surface layers formed on Cu, Cu-Ni, Cu-Zn and Cu-Ni-Zn in clean and polluted environments

    Graphical abstract: - Highlights: • Mixed oxides were detected over Cu-Zn while only Cu2O is detected over Cu-Ni surface. • Mixed oxides/hydroxides were detected on the surface of Cu-Ni-Zn. • Although ZnS is a wide bandgap semiconductor, it enhances the ionic conduction. • Both XPS and XRD analyses confirm the absence of any copper sulphide in case of Cu-Ni-Zn. • Polysulfide (S8) is formed on the surface of Cu-Ni and Cu-Zn. - Abstract: The performance of copper and copper-based alloys in working environments is controlled by the composition of the layers formed on their surfaces. Herein, we report the detailed structural and compositional analyses of the layers formed on the surface of Cu, Cu-Ni, Cu-Zn and Cu-Ni-Zn upon their use in both NaCl and Na2S-polluted NaCl solutions. In clean NaCl environments, X-ray photoelectron spectroscopy (XPS) analysis revealed that Cu2O is the major compound formed over the surfaces of pure Cu and Cu-Ni, whereas mixed oxides/hydroxides were detected over the surfaces of Cu-Zn (Cu2O and ZnO) and Cu-Ni-Zn alloy (CuO, ZnO, Cu(OH)2 and Ni(OH)2). However, in Na2S- polluted NaCl environments, sulphide compounds (such as Cu2S) were detected on the surfaces of Cu-Ni and Cu-Zn. X-ray diffraction (XRD) analysis confirmed the XPS findings, where Cu2O was confirmed in case of Cu and CuO in case of Cu-Ni-Zn in pure NaCl solutions. However, in sulphide-polluted media, compounds such as Cu4(S2)2(CuS)2 were identified in case of Cu-Ni, and CuS in case of Cu-Zn. Further, the morphology of the surface of Cu-Ni-Zn tested in Na2S-polluted NaCl solution looks compact and has a wide band gap (4.47 eV) as revealed from the UV–vis absorption measurements. Therefore, the formation of mixed oxides/hydroxides and/or sulphides on the surface of Cu-Ni-Zn alloy is ultimately responsible for the enhancement of its dissolution resistance

  9. Unravelling the composition of the surface layers formed on Cu, Cu-Ni, Cu-Zn and Cu-Ni-Zn in clean and polluted environments

    Awad, Nasser K.; Ashour, E.A. [National Research Centre, Electrochemistry and Corrosion Lab., Dokki, Cairo 12422 (Egypt); Allam, Nageh K., E-mail: nageh.allam@aucegypt.edu [National Research Centre, Electrochemistry and Corrosion Lab., Dokki, Cairo 12422 (Egypt); Energy Materials Laboratory (EML), Physics Department, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835 (Egypt)

    2015-08-15

    Graphical abstract: - Highlights: • Mixed oxides were detected over Cu-Zn while only Cu{sub 2}O is detected over Cu-Ni surface. • Mixed oxides/hydroxides were detected on the surface of Cu-Ni-Zn. • Although ZnS is a wide bandgap semiconductor, it enhances the ionic conduction. • Both XPS and XRD analyses confirm the absence of any copper sulphide in case of Cu-Ni-Zn. • Polysulfide (S{sub 8}) is formed on the surface of Cu-Ni and Cu-Zn. - Abstract: The performance of copper and copper-based alloys in working environments is controlled by the composition of the layers formed on their surfaces. Herein, we report the detailed structural and compositional analyses of the layers formed on the surface of Cu, Cu-Ni, Cu-Zn and Cu-Ni-Zn upon their use in both NaCl and Na{sub 2}S-polluted NaCl solutions. In clean NaCl environments, X-ray photoelectron spectroscopy (XPS) analysis revealed that Cu{sub 2}O is the major compound formed over the surfaces of pure Cu and Cu-Ni, whereas mixed oxides/hydroxides were detected over the surfaces of Cu-Zn (Cu{sub 2}O and ZnO) and Cu-Ni-Zn alloy (CuO, ZnO, Cu(OH){sub 2} and Ni(OH){sub 2}). However, in Na{sub 2}S- polluted NaCl environments, sulphide compounds (such as Cu{sub 2}S) were detected on the surfaces of Cu-Ni and Cu-Zn. X-ray diffraction (XRD) analysis confirmed the XPS findings, where Cu{sub 2}O was confirmed in case of Cu and CuO in case of Cu-Ni-Zn in pure NaCl solutions. However, in sulphide-polluted media, compounds such as Cu{sub 4}(S{sub 2}){sub 2}(CuS{sub )2} were identified in case of Cu-Ni, and CuS in case of Cu-Zn. Further, the morphology of the surface of Cu-Ni-Zn tested in Na{sub 2}S-polluted NaCl solution looks compact and has a wide band gap (4.47 eV) as revealed from the UV–vis absorption measurements. Therefore, the formation of mixed oxides/hydroxides and/or sulphides on the surface of Cu-Ni-Zn alloy is ultimately responsible for the enhancement of its dissolution resistance.

  10. Thermodynamic studies on LnCoO3(s) (Ln = Dy, Ho) by solid-state electrochemical cells

    Ternary oxides, DyCoO3(s) and HoCoO3(s) have been synthesized by citrate-nitrate gel combustion method and characterized by X-ray powder diffraction method. The standard molar Gibbs energies of formation of DyCoO3(s) and HoCoO3(s) have been measured using solid oxide galvanic cell technique employing yttria-stabilized zirconia (YSZ) and calcia-stabilized zirconia (CSZ) as solid electrolyte tubes, respectively. The standard molar Gibbs energies of formation of DyCoO3(s) and HoCoO3(s) were calculated from the measured e.m.f. data and are given as: ΔfGmo(DyCoO3,s,T)kJmol-1(±4)=-1211.3+0.2449*(TK),(1013K≤T≥1167K), ΔfGmo(HCoO3,s,T)kJmol-1(±4)=-1237.8+0.2590*(TK).(964K≤T≥1102K), A set of self consistent thermodynamic functions for LnCoO3(s) (Ln = La, Nd, Sm, Eu, Gd, Dy, Ho) has been computed from available experimental data in the literature

  11. Break spectrum analyses for small break loss of coolant accidents in a RESAR-3S Plant

    A series of thermal-hydraulic analyses were performed to investigate phenomena occurring during small break loss-of-coolant-accident (LOCA) sequences in a RESAR-3S pressurized water reactor. The analysis included simulations of plant behavior using the TRAC-PF1 and RELAP5/MOD2 computer codes. Series of calculations were performed using both codes for different break sizes. The analyses presented here also served an audit function in that the results shown here were used by the US Nuclear Regulatory Commission (NRC) as an independent confirmation of similar analyses performed by Westinghouse Electric Company using another computer code. 10 refs., 62 figs., 14 tabs

  12. Diffusion of sulfur 35S in β-Ni3S2

    The diffusion of 35S radioisotope in β-Ni3S2 polycrystals was studied at temperatures ranging from 848 to 893 K and at sulfur vapour pressure (5.6 x 10-6 - 3.2 x 10-4) Pa. The autoradiography and the tracer sectioning method were used. It was found that the bulk diffusion is the main process of sulfur transport. The activation energy of the diffusion equals (190±10) kJmol-1. Under the conditions used in the experiments the dominant anionic point defects are single-ionized vacancies and quasi-free electrons. (author)

  13. Shape-independent expansion for the 3S1 - 3D1 mixing parameter

    A low-energy shape-independent expansion is suggested for the function [tan(2εBB)/(2 k2)], where εBB is the Blatt-Biedenharn mixing parameter for the 3 S1-3 D1 channel. This expansion allows an evaluation of the mixing parameters εBB from a knowledge of the deuteron asymptotic D to S ratio, pion mass and other low-energy observables, such as the scattering lengths, deuteron binding etc., of the nucleon-nucleon system. It is demonstrated that the correct long range behavior of the tensor potential is essential for a realistic reproduction of εBB. (author)

  14. Measuring the free neutron lifetime to <= 0.3s via the beam method

    Mulholland, Jonathan; Fomin, Nadia; BL3 Collaboration

    2015-10-01

    Neutron beta decay is an archetype for all semi-leptonic charged-current weak processes. A precise value for the neutron lifetime is required for consistency tests of the Standard Model and is needed to predict the primordial 4He abundance from the theory of Big Bang Nucleosynthesis. An effort has begun for an in-beam measurement of the neutron lifetime with an projected large area silicon detector technology address the two largest sources of uncertainty of in-beam measurements, paving the way for a new measurement. The experimental design and projected uncertainties for the 0.3s measurement will be discussed.

  15. Spectroscopy of the hydrogen 1 S -3 S transition with chirped laser pulses

    Yost, D. C.; Matveev, A.; Grinin, A.; Peters, E.; Maisenbacher, L.; Beyer, A.; Pohl, R.; Kolachevsky, N.; Khabarova, K.; Hänsch, T. W.; Udem, Th.

    2016-04-01

    We identify a systematic present in two-photon direct frequency comb spectroscopy (DFCS) which is a result of chirped laser pulses and is a manifestation of the first-order Doppler effect. We carefully analyze this systematic and propose methods for its mitigation within the context of our measurement of the hydrogen 1 S -3 S transition. We also report on our determination of the absolute frequency of this transition, which is comparable to a previous measurement using continuous-wave spectroscopy [O. Arnoult et al., Eur. Phys. J. D 60, 243 (2010), 10.1140/epjd/e2010-00249-6], but was obtained with a different experimental method.

  16. Atomic layer deposition of ultrathin Cu{sub 2}O and subsequent reduction to Cu studied by in situ x-ray photoelectron spectroscopy

    Dhakal, Dileep [Center for Microtechnologies—ZfM, Technische Universität Chemnitz, D-09107 Chemnitz (Germany); Assim, Khaybar; Lang, Heinrich [Institute of Chemistry, Inorganic Chemistry, Technische Universität Chemnitz, D-09107 Chemnitz (Germany); Bruener, Philipp; Grehl, Thomas [ION-TOF GmbH, Heisenbergstr. 15, D-48149 Münster (Germany); Georgi, Colin; Waechtler, Thomas; Ecke, Ramona; Schulz, Stefan E., E-mail: stefan.schulz@zfm.tu-chemnitz.de; Gessner, Thomas [Center for Microtechnologies—ZfM, Technische Universität Chemnitz, D-09107 Chemnitz, Germany and Fraunhofer Institute for Electronic Nano Systems—ENAS, Technologie-Campus 3, D-09126 Chemnitz (Germany)

    2016-01-15

    The growth of ultrathin (<5 nm) Ru-doped Cu{sub 2}O films deposited on SiO{sub 2} by atomic layer deposition (ALD) and Cu films by subsequent reduction of the Cu{sub 2}O using HCO{sub 2}H or CO is reported. Ru-doped Cu{sub 2}O has been deposited by a mixture of 16: 99 mol. % of [({sup n}Bu{sub 3}P){sub 2}Cu(acac)] as Cu precursor and 17: 1 mol. % of [Ru(η{sup 5}-C{sub 7}H{sub 11})(η{sup 5}-C{sub 5}H{sub 4}SiMe{sub 3})] as Ru precursor. The catalytic amount of Ru precursor was to support low temperature reduction of Cu{sub 2}O to metallic Cu by formic acid (HCO{sub 2}H) on arbitrary substrate. In situ x-ray photoelectron spectroscopy investigations of the Cu{sub 2}O ALD film indicated nearly 1 at. % of carbon contamination and a phosphorous contamination below the detection limit after sputter cleaning. Systematic investigations of the reduction of Ru-doped Cu{sub 2}O to metallic Cu by HCO{sub 2}H or CO as reducing agents are described. Following the ALD of 3.0 nm Cu{sub 2}O, the ultrathin films are reduced between 100 and 160 °C. The use of HCO{sub 2}H at 110 °C enabled the reduction of around 90% Cu{sub 2}O. HCO{sub 2}H is found to be very effective in the removal of oxygen from Ru-doped Cu{sub 2}O films with 2.5–4.7 nm thickness. In contrast, CO was effective for the removal of oxygen from the Cu{sub 2}O films only below 3.0 nm at 145 °C. Root mean square surface roughness of 0.4 ± 0.1 nm was observed from atomic force microscopy (AFM) investigations after the ALD of Cu{sub 2}O, followed by the subsequent reduction of 3.0 nm Cu{sub 2}O using either HCO{sub 2}H at 110 °C or CO at 145 °C on SiO{sub 2}. Furthermore, ex situ low energy ion scattering and AFM investigations confirmed that the Cu{sub 2}O film after ALD and Cu films after subsequent reduction was continuous on the SiO{sub 2} substrate.

  17. Application of an electro-optical modulator in inelastic collision studies with laser-excited Na*(3p) atoms

    In atomic collision experiments with laser-excited target atoms it is often desirable to maximize the fraction f* of excited atoms. In the case of Na atoms pumped by a single mode CW dye laser radiation several effects including hyperfine pumping limit f* to about 10%. Using two side-bands of laser radiation, produced by means of an electro-optical modulator (phase modulation of laser radiation by a LiTaO3 crystal in a microwave field) transitions from both hyperfine ground states of Na can be pumped simultaneously. In this way a significant increase of the fraction of excited Na atoms in the 32P states to typically 30% could be achieved. The advantage of using an electro-optical modulator is demonstrated for the case of state-selective single electron capture studies of the He2+-Na*(3p) collision system. (author)

  18. Synthesis and characterization of Fe3P composite nanorods produced by phosphate reduction in anodized alumina templates

    A synthetic method for nanoscale iron phosphide rod production based on reductive annealing of iron phosphate deposited in porous alumina membranes has been explored. Two methods of pore filling, incipient wetness and drip-drying of precursor phosphate particles, were investigated. Reduction was carried out in a flowing H2/Ar atmosphere at 650-800 deg. C for 2 h and the template was removed by dissolution in NaOH. Particle morphology, composition and phase were examined by scanning electron microscopy, transmission electron microscopy, scanning transmission electron microscopy and energy-dispersive spectroscopy. The data suggest that rods are formed as heterogeneous structures comprising Fe3P nanoparticles within an amorphous matrix

  19. Phase-formation in K2O-Er2O3-P2O5-H2O system

    The K2O-Er2O3-P2O5-H2O system in the condensed phosphates crystallization at 300 and 500 deg C and constant pressUre of saturated water vapours by the method is investigated. Crystallization tregions of eight condensed erbium phosphates haVe been found out: two varieties of ErP5O14 ultraphosphates, two Er(PO3)3 polyphospates (Q and R phases), KErP4O12-A double cyclotetraphosphate and three double KEr)/PO3)4 of 3, 4 and 7 types, polyphosphates the KEr(PO3)4 - 7 and Er(PO3)3 - R types are obtained for the first time. Roentgenometric, morphological, crystalloptical and IR spectroscopic characteristics of condensed erbium phosphates are given

  20. Interactions of solute (3p, 4p, 5p and 6p) with solute, vacancy and divacancy in bcc Fe

    You, Yu-Wei; Kong, Xiang-Shan; Wu, Xue-Bang; Liu, Wei [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Liu, C.S., E-mail: csliu@issp.ac.cn [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Fang, Q.F. [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Chen, J.L.; Luo, G.-N. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wang, Zhiguang [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2014-12-15

    Solute–vacancy binding energy is a key quantity in understanding solute diffusion kinetics and phase segregation, and may help choice of alloy compositions for future material design. However, the binding energy of solute with vacancy is notoriously difficult to measure and largely unknown in bcc Fe. With first-principles method, we systemically calculate the binding energies of solute (3p, 4p, 5p and 6p alloying solutes are included) with vacancy, divacancy and solute in bcc Fe. The binding energy of Si with vacancy in the present work is in good consistent with experimental value available. All the solutes considered are able to form stable solute–vacancy, solute–divacancy complexes, and the binding strength of solute–divacancy is about two times larger than that of solute–vacancy. Most solutes could not form stable solute–solute complexes except S, Se, In and Tl. The factors controlling the binding energies are analyzed at last.

  1. On mechanism of Ar(3p54p) states excitation in low-energy Ar-Ar collisions

    The present work is devoted to study of Ar(3p54p) states excitation in binary low-energy Ar-Ar collisions. The results of the experimental investigation of excitation cross sections of Ar I 4p'[l/2]1, 4p'[3/2]1, 4p'[3/2]2 and 4p[3/2]2 levels in the collision energy range from threshold up to 500 eV (cm) and degree of polarization for 4s[3/2]20-4p'[l/2]1 and 4s[3/2]20-4p[3/2]2 transitions in this energy range are represented.

  2. Interactions of solute (3p, 4p, 5p and 6p) with solute, vacancy and divacancy in bcc Fe

    Solute–vacancy binding energy is a key quantity in understanding solute diffusion kinetics and phase segregation, and may help choice of alloy compositions for future material design. However, the binding energy of solute with vacancy is notoriously difficult to measure and largely unknown in bcc Fe. With first-principles method, we systemically calculate the binding energies of solute (3p, 4p, 5p and 6p alloying solutes are included) with vacancy, divacancy and solute in bcc Fe. The binding energy of Si with vacancy in the present work is in good consistent with experimental value available. All the solutes considered are able to form stable solute–vacancy, solute–divacancy complexes, and the binding strength of solute–divacancy is about two times larger than that of solute–vacancy. Most solutes could not form stable solute–solute complexes except S, Se, In and Tl. The factors controlling the binding energies are analyzed at last

  3. Magnetic control of ultra-cold $^6$Li and $^{174}$Yb($^3P_2$) atom mixtures with Feshbach resonances

    Petrov, Alexander; Kotochigova, Svetlana

    2015-01-01

    We theoretically evaluate the feasibility to form magnetically-tunable Feshbach molecules in collisions between fermionic $^6$Li atoms and bosonic metastable $^{174}$Yb($^3$P$_2$) atoms. In contrast to the well-studied alkali-metal atom collisions, collisions with meta-stable atoms are highly anisotropic. Our first-principle coupled-channel calculation of these collisions reveals the existence of broad Feshbach resonances due to the combined effect of anisotropic-molecular and atomic-hyperfine interactions. In order to fit our predictions to the specific positions of experimentally-observed broad resonance structures \\cite{Deep2015} we optimized the shape of the short-range potentials by direct least-square fitting. This allowed us to identify the dominant resonance by its leading angular momentum quantum numbers and describe the role of collisional anisotropy in the creation and broadening of this and other resonances.

  4. Theoretical investigation of the dynamics of O(1D→3P) electronic quenching by collision with Xe

    We present the quantum close-coupling treatment of spin-orbit induced transitions between the 1D and 3P states of an atom in collisions with a closed-shell spherical partner. In the particular case of O colliding with Xe, we used electronic structure calculations to compute the relevant potential energy curves and spin-orbit coupling matrix elements. We then carried out quantum scattering calculations of integral and differential quenching cross sections as functions of the collision energy. The calculated differential cross sections for electronic quenching are in reasonable agreement with measurements [Garofalo et al., J. Chem. Phys. 143, 054307 (2015)]. The differential cross sections exhibit pronounced oscillations as a function of the scattering angle. By a semiclassical analysis, we show that these oscillations result from quantum mechanical interference between two classical paths

  5. Electron-phonon superconductivity in APt3P (A=Sr, Ca, La) compounds: From weak to strong coupling

    Subedi, Alaska; Ortenzi, Luciano; Boeri, Lilia

    2013-04-01

    We study the newly discovered Pt phosphides APt3P (A=Sr, Ca, La) [T. Takayama , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.108.237001 108, 237001 (2012)] using first-principles calculations and Migdal-Eliashberg theory. Given the remarkable agreement with the experiment, we exclude the charge-density wave scenario proposed by previous first-principles calculations, and give conclusive answers concerning the superconducting state in these materials. The pairing increases from La to Ca and Sr due to changes in the electron-phonon matrix elements and low-frequency phonons. Although we find that all three compounds are well described by conventional s-wave superconductivity and spin-orbit coupling of Pt plays a marginal role, we show that it could be possible to tune the structure from centrosymmetric to noncentrosymmetric opening new perspectives towards the understanding of unconventional superconductivity.

  6. Polarization effects in metastable neon atom (Ne* ( 3P 2)) on ground state neon atom collision at thermal energy

    Baudon, J.; Perales, F.; Miniatura, Ch.; Robert, J.; Vassilev, G.; Reinhardt, J.; Haberland, H.

    1990-08-01

    The difference Δ between the differential cross section for Ne*( 3P 2 atoms polarized either in state | j=2, m=+2 > or | j=2, m=-2 >, colliding at thermal energy with a groundstate target (Ne,O 2), is measured. In the symmetric case Ne*-Ne, direct and exchange contribution are observed. General properties of Δ, derived from symmetry considerations, are established; in particular: (i) the interference character of Δ, (ii) the role played by the azimuthal dependence of the scattering amplitudes, (iii) the property Δ(0) = Δ(180°)=0. The relationship between the Fourier harmonics introduced in this discussion and the scattering amplitudes used in standard collision treatments are given.

  7. The C(3P) + NH3 reaction in interstellar chemistry: I. Investigation of the product formation channels

    Bourgalais, Jeremy; Kailasanathan, Ranjith Kumar Abhinavam; Osborn, David L; Hickson, Kevin M; Loison, Jean-Christophe; Wakelam, Valentine; Goulay, Fabien; Picard, Sébastien D Le

    2016-01-01

    The product formation channels of ground state carbon atoms, C(3P), reacting with ammonia, NH3, have been investigated using two complementary experiments and electronic structure calculations. Reaction products are detected in a gas flow tube experiment (330 K, 4 Torr) using tunable VUV photoionization coupled with time of flight mass spectrometry. Temporal profiles of the species formed and photoionization spectra are used to identify primary products of the C + NH3 reaction. In addition, H-atom formation is monitored by VUV laser induced fluorescence from room temperature to 50 K in a supersonic gas flow generated by the Laval nozzle technique. Electronic structure calculations are performed to derive intermediates, transition states and complexes formed along the reaction coordinate. The combination of photoionization and laser induced fluorescence experiments supported by theoretical calculations indicate that in the temperature and pressure range investigated, the H + H2CN production channel represents ...

  8. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines

    Henry, Jon C. [Department of Surgery, Ohio State University Medical Center, Columbus, OH (United States); Park, Jong-Kook; Jiang, Jinmai; Kim, Ji Hye [College of Pharmacy, Ohio State University, Columbus, OH (United States); Nagorney, David M.; Roberts, Lewis R. [Divisions of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN (United States); Banerjee, Soma [Center for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata (India); Schmittgen, Thomas D., E-mail: Schmittgen.2@osu.edu [College of Pharmacy, Ohio State University, Columbus, OH (United States)

    2010-12-03

    Research highlights: {yields} miR-199a-3p targets CD44 in HCC. {yields} Proliferation and invasion are reduced by miR-199a-3p in CD44+ HCC. {yields} miR-199a-3p is reduced and CD44 protein is increased in HCC tissues. {yields} The duplex form of miR-199a-3p mimetic is required for activity. -- Abstract: Previous work by us and others reported decreased expression of miR-199a-3p in hepatocellular carcinoma (HCC) tissues compared to adjacent benign tissue. We report here a significant reduction of miR-199a-3p expression in 7 HCC cell lines. To determine if miR-199a-3p has a tumor suppressive role, pre-miR-199a-3p oligonucleotides were transfected into the HCC cell lines. Pre-miR-199a-3p oligonucleotide reduced cell proliferation by approximately 60% compared to control oligonucleotide in only two cell lines (SNU449 and SNU423); the proliferation of the other 5 treated cell lines was similar to control oligonucleotide. A pre-miR-199a-3p oligonucleotide formulated with chemical modifications to enhance stability while preserving processing, reduced cell proliferation in SNU449 and SNU423 to the same extent as the commercially available pre-miR-199a-3p oligonucleotide. Furthermore, only the duplex miR-199a-3p oligonucleotide, and not the guide strand alone, was effective at reducing cell viability. Since a CD44 variant was essential for c-Met signaling [V. Orian-Rousseau, L. Chen, J.P. Sleeman, P. Herrlich, H. Ponta, CD44 is required for two consecutive steps in HGF/c-Met signaling, Genes Dev. 16 (2002) 3074-3086] and c-Met is a known miR-199a-3p target, we hypothesized that miR-199a-3p may also target CD44. Immunoblotting confirmed that only the two HCC lines that were sensitive to the effects of pre-miR-199a-3p were CD44+. Direct targeting of CD44 by miR-199a-3p was confirmed using luciferase reporter assays and immunoblotting. Transfection of miR-199a-3p into SNU449 cells reduced in vitro invasion and sensitized the cells to doxorubicin; both effects were enhanced

  9. Detection of S1-P1 and S3-P3 interactions between papain and four synthetic substrates

    Emmanuel M Papamichael

    1999-01-01

    Full Text Available In this study, the S1 - P1 and S3 - P3 interactions between papain and four synthetic peptide substrates were found as to be important. The values of Km were estimated as to be practically identical between these substrates; this latter is supporting the conclusions obtained by considering the estimated values of other kinetic parameters. Nevertheless, based on the estimated kcat and/or k cat/Km parameters of the used substrates, we concluded that an aromatic ring at the P3 position, and a positively charged side chain of the residue at the P1 position of the synthetic substrates were favored considerably their interaction with papain.Neste estudo, o S1 - P1 e S3 - P3, interações entre papaina e quatro substratos sintéticos de pepetídios foram considerados importantes. Os valores de Km foram estimados e são praticamente idênticos entre esses substratos; Isso dá suporte as conclusões obtidas, considerando os valores parâmetros cinéticos estimados. No obstante, baseou na estimação parâmetros kcat e/ou k cat /Km dos substratos utilizados. Se pode concluir que um anel aromático na posição P3, e uma corrente carregada positivamente da cadeia do resíduo na posição P1 dos substratos sintéticos favoreceram interação com a papaina.

  10. Major weapon system environmental life-cycle cost estimating for Conservation, Cleanup, Compliance and Pollution Prevention (C3P2)

    Hammond, Wesley; Thurston, Marland; Hood, Christopher

    1995-01-01

    The Titan 4 Space Launch Vehicle Program is one of many major weapon system programs that have modified acquisition plans and operational procedures to meet new, stringent environmental rules and regulations. The Environmental Protection Agency (EPA) and the Department of Defense (DOD) mandate to reduce the use of ozone depleting chemicals (ODC's) is just one of the regulatory changes that has affected the program. In the last few years, public environmental awareness, coupled with stricter environmental regulations, has created the need for DOD to produce environmental life-cycle cost estimates (ELCCE) for every major weapon system acquisition program. The environmental impact of the weapon system must be assessed and budgeted, considering all costs, from cradle to grave. The Office of the Secretary of Defense (OSD) has proposed that organizations consider Conservation, Cleanup, Compliance and Pollution Prevention (C(sup 3)P(sup 2)) issues associated with each acquisition program to assess life-cycle impacts and costs. The Air Force selected the Titan 4 system as the pilot program for estimating life-cycle environmental costs. The estimating task required participants to develop an ELCCE methodology, collect data to test the methodology and produce a credible cost estimate within the DOD C(sup 3)P(sup 2) definition. The estimating methodology included using the Program Office weapon system description and work breakdown structure together with operational site and manufacturing plant visits to identify environmental cost drivers. The results of the Titan IV ELCCE process are discussed and expanded to demonstrate how they can be applied to satisfy any life-cycle environmental cost estimating requirement.

  11. MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.

    Huizi Lei

    Full Text Available BACKGROUND AIMS: Gastric cancer is the most frequent gastrointestinal tumor in adults and is the most lethal form of human cancer. Despite of the improvements in treatments, the underlying mechanism of gastric carcinogenesis is not well known. To define novel modulators that regulate susceptibility to tumorgenesis, we focused on miR-219-2-3p. METHODS: Quantitative RT-PCR was employed to investigate the level of miR-219-2-3p in gastric cancer (GC tissues (n = 113 and their matched adjacent normal tissues (n = 113. In vitro cell proliferation, apoptosis assays, cell migration, and invasion assays were performed to elucidate biological effects of miR-219-2-3p. Since silencing of miRNA by promoter CpG island methylation may be an important mechanism in tumorgenesis, GC cells were treated with 5-aza-2'-deoxycytidine and trichostatin A, and expression changes of miR-219-2-3p were subsequently examined by quantitative RT-PCR. Finally, the methylation status of CpG island upstream of miR-219-2-3p was analyzed by methylation-specific PCR in GC tissues (n = 22. RESULTS: miR-219-2-3p was down-regulated in GC and cell lines. In addition, the experiments documented the lower expression of miR-219-2-3p in GC specimens with higher grade and later stage tumors. Meanwhile, miR-219-2-3p exerted antiproliferative, proapoptotic, and antimetastatic roles and reduced levels of p-ERK1/2 in GC cells. Furthermore, 5-aza-2'-deoxycytidine and trichostatin A increased the expression (~2 fold of miR-219-2-3p in GC cells. By methylation-specific PCR, DNA methylation in the upstream region of miR-219-2-3p was detected in both adjacent normal tissues and cancer tissues. As expected, the methylation level was considerably higher in the miR-219-2-3p down-regulated group than up-regulated group. CONCLUSIONS: miR-219-2-3p is potentially involved in gastric cancer progression and metastasis by regulating ERK1/2-related signal pathways, which may provide a novel therapeutic strategy

  12. Discrimination and detection limits of secondary phases in Cu2ZnSnS4 using X-ray diffraction and Raman spectroscopy

    The formation of single-phase Cu2ZnSnS4 thin films is known to be challenging, mainly due to the difficulties to detect secondary phases in the Cu2ZnSnS4 system. Here, the ability to quantitatively discriminate the most likely secondary phases ZnS and Cu2SnS3 from Cu2ZnSnS4 using common approaches but also using more complex and time-consuming Rietveld refinement analysis techniques to analyse X-ray diffractograms is investigated in a comparative study to the peak analysis of Raman spectra measured with standard conditions. In studying not only individual samples of the respective phases but also a phase-gradient sample containing various amounts of Cu2SnS3 and ZnS alongside Cu2ZnSnS4, we found that refinement analyses can only discriminate more than 10% ZnS and 50% Cu2SnS3 from Cu2ZnSnS4, respectively. In comparison, Raman measurements performed with green-wavelength excitation can discern more than 30% Cu2SnS3 from Cu2ZnSnS4 while ZnS is indiscernible. The results show that the identification of secondary phases in the Cu2ZnSnS4 system is more difficult than currently assumed in literature. Furthermore, the potential of multiple-wavelength Raman spectroscopy as a tool to identify ZnS secondary phases is shown. Characterization of a Sn-rich sample (composition nearly Cu2ZnSn3S8) shows no sign of a Sn-rich quaternary phase, questioning its existence under typical annealing conditions. - Highlights: • XRD cannot be used to identify < 10% ZnS or < 50% Cu2SnS3 in a mixed Cu2ZnSnS4 sample. • Green light Raman spectroscopy can't discern < 30% Cu2SnS3 in a Cu2ZnSnS4 sample. • Green light Raman spectroscopy can't discern ZnS in a mixed Cu2ZnSnS4 sample at all. • Multiple-wavelength Raman spectroscopy is useful to discern ZnS from Cu2ZnSnS4. • Cu2ZnSn3S8 could not be confirmed in a thin film made by a typical growth process

  13. Investigation of Spectra (NMR, Mass) of Some Fe3S3 Cluster Compounds

    刘平; 王艰; 陈忠; 彭奇

    2000-01-01

    The chemical shifts of 1H-NMR of five Fe3S3 cluster compounds wereassigned. The main chemical shift values are: δcH3 = 1. 095 - 1. 946, δCH2 = 2. 882 -3.803, δC6Hn = 7. 547 7. 172. In comparison with those of pure (CH3CH2)3N andthiophenol, these values are moved to high position, and the width of these peaks is ob-viously increased. These characteristics conformed to NMR spectra of paramagneticcompounds and their molecular structures. The paramagnetic property of these com-pounds was also studied with ESR spectrum. Mass spectra of three compounds were de-termined. The main fragments were observed, for example, m/z: 130 [(C2H5)4N]+,264[Fe3S3] +, 144[Fe-S-Fe] +, 120[S-Fe-S]+, 88[Fe-S]+, 136[FeBr]+, 91[FeCl] + etc. These supported structural characteristics of the anion skeleton and molecules strongly. The possible mechanism of fragmentation was discussed.

  14. An Integrated 3S and Historical Materials Analysis of the Keriya Paleoriver, NW China

    Luo, Lei; Wang, Xinyuan; Cai, Heng

    2014-03-01

    Combining analysis of 3S (RS, GIS and GPS) and historical materials (historical records, ancient map and academic and literary writings) allows mapping of the Keriya Paleoriver of Southern Xinjiang, NW China. Keriya Paleoriver, one of the ancient Four Green Corridors which passes through the Taklimakan Desert from south to north in the Tarim Basin, recorded changes of the climate-environment in the ancient Silk Road of the region. According to the archaeological data, historical materials and paleoclimates information, its eco-environment and climate have had great changes since the 1.09Ma B.P., especially during the last 2,000 years, which has led to many famous ancient cities to be abandoned and the route of the ancient Silk Road to be moved southward. Using RS (optical and radar imagery), GIS (mapping and spatial analysis) and GPS (study area investigation), we mapped a major paleodrainage system of Keriya River, which have linked the Kunlun Mountains to the Tienshan Mountains through the Taklimakan Desert, possibly as far back as the early Pleistocene. This study illustrates the capability of the 3S and historical materials, in mapping the Keriya Paleoriver drainage networks and archaeological study on the ancient Silk Road.

  15. Study of dipion transitions among Υ(3S), Υ(2S), and Υ(1S) states

    We present measurements of decay matrix elements for hadronic transitions of the form Υ(nS)→Υ(mS)ππ, where (n,m)=(3,1),(2,1),(3,2). We reconstruct charged and neutral pion modes with the final state Upsilon decaying to either μ+μ- or e+e-. Dalitz plot distributions for the 12 decay modes are fit individually as well as jointly assuming isospin symmetry, thereby measuring the matrix elements of the decay amplitude. We observe and account for the anomaly previously noted in the dipion invariant mass distribution for the Υ(3S)→Υ(1S)ππ transition and obtain good descriptions of the dynamics of the decay using the most general decay amplitude allowed by partial conservation of the axial-vector current considerations. The fits further indicate that the Υ(2S)→Υ(1S)ππ and Υ(3S)→Υ(2S)ππ transitions also show the presence of terms in the decay amplitude that were previously ignored, although at a relatively suppressed level

  16. The Copernicus Climate Change Service (C3S): A European Answer to Climate Change

    Thepaut, Jean-Noel

    2016-04-01

    Copernicus is the European Commission's flagship Earth observation programme that delivers freely accessible operational data and information services. ECMWF has been entrusted to operate two key parts of the Copernicus programme, which will bring a consistent standard to the measurement, forecasting and prediction of atmospheric conditions and climate change: • The Copernicus Atmosphere Monitoring Service, CAMS, provides daily forecasts detailing the makeup composition of the atmosphere from the ground up to the stratosphere. • The Copernicus Climate Change Service (C3S) (in development) will routinely monitor and analyse more than 20 essential climate variables to build a global picture of our climate, from the past to the future, as well as developing customisable climate indicators for relevant economic sectors, such as energy, water management, agriculture, insurance, health…. C3S has now taken off and a number of proof-of-concept sectoral climate services have been initiated. This paper will focus on the description and expected outcome of these proof-of-concept activities as well as the definition of a roadmap towards a fully operational European Climate Change Service.

  17. An Integrated 3S and Historical Materials Analysis of the Keriya Paleoriver, NW China

    Combining analysis of 3S (RS, GIS and GPS) and historical materials (historical records, ancient map and academic and literary writings) allows mapping of the Keriya Paleoriver of Southern Xinjiang, NW China. Keriya Paleoriver, one of the ancient Four Green Corridors which passes through the Taklimakan Desert from south to north in the Tarim Basin, recorded changes of the climate-environment in the ancient Silk Road of the region. According to the archaeological data, historical materials and paleoclimates information, its eco-environment and climate have had great changes since the 1.09Ma B.P., especially during the last 2,000 years, which has led to many famous ancient cities to be abandoned and the route of the ancient Silk Road to be moved southward. Using RS (optical and radar imagery), GIS (mapping and spatial analysis) and GPS (study area investigation), we mapped a major paleodrainage system of Keriya River, which have linked the Kunlun Mountains to the Tienshan Mountains through the Taklimakan Desert, possibly as far back as the early Pleistocene. This study illustrates the capability of the 3S and historical materials, in mapping the Keriya Paleoriver drainage networks and archaeological study on the ancient Silk Road

  18. Void formation in neutron-irradiated Cu and Cu alloys

    Pure copper and copper-aluminium alloys were neutron-irradiated at high temperatures in the as-received condition, and after being melted under high vacuum or in argon. Melting under high vacuum was done to reduce the residual gas amount in the specimens. The number density of voids in the vacuum-melted Cu was one tenth of that in as-received Cu after JMTR irradiation to 5.2 x 1024 n/m2 at 603 K. Similarly, voids were also formed in an argon-melted Cu-1at%Al specimen but were not formed in a vacuum-melted one. Following higher dose irradiation in the JOYO reactor, nearly the same number density and size of voids were formed in both argon and vacuum-melted Cu. In Cu-5at%Al, many voids were formed in argon-melted specimens, whereas in vacuum-melted specimens voids were not formed. These results show that voids nucleate at vacancy clusters which trap gas atoms. In the JOYO irradiation, diffused-in gas atoms play an important role in the formation of voids in Cu. In Cu-5at%Al, diffused-in gas atoms were trapped by Al atoms, resulting in a difference of void formation between the two types of specimens. (orig.)

  19. Copper tin sulfide (CTS) absorber thin films obtained by co-evaporation: Influence of the ratio Cu/Sn

    Highlights: • Copper tin sulfide (CTS) thin films were grown by co-evaporation at different Cu/Sn atomic ratios. • Smooth Cu2SnS3 layers with large grains are obtained at Cu/Sn ⩾ 1.5 and T ⩾ 350 °C. • At 450 °C, the cubic Cu2SnS3 phase changes to tetragonal phase. • Cu2SnS3 presents suitable optical and electrical properties for use as photovoltaic absorbers. - Abstract: Copper tin sulfide thin films have been grown on soda-lime glass substrates from the elemental constituents by co-evaporation. The synthesis was performed at substrate temperatures of 350 °C and 450 °C and different Cu/Sn ratios, adjusting the deposition time in order to obtain thicknesses above 1000 nm. The evolution of the morphological, structural, chemical, optical and electrical properties has been analyzed as a function of the substrate temperature and the Cu/Sn ratio. For the samples with Cu/Sn ⩽ 1, Cu2Sn3S7 and Cu2SnS3 have been observed by XRD. Increasing the Cu/Sn to 1.5, the Cu2SnS3 phase was the majority, being the formation completed at Cu/Sn ratio around 2. The increment of the substrate temperature leads to a change of cubic structure to tetragonal of the Cu2SnS3 phase. The chemical treatment with KCN was effective to eliminate CuS excess detected in the samples with Cu/Sn > 2.2. The samples with Cu2SnS3 structure show a band gap energy increasing from 0.9 to 1.25 eV and an electrical resistivity decreasing from 7 ∗ 10−2 Ω cm to 3 ∗ 10−3 Ω cm when the Cu/Sn atomic ratio increases from 1.5 to 2.2

  20. Copper tin sulfide (CTS) absorber thin films obtained by co-evaporation: Influence of the ratio Cu/Sn

    Robles, V., E-mail: victor.robles@ciemat.es; Trigo, J.F.; Guillén, C.; Herrero, J.

    2015-09-05

    Highlights: • Copper tin sulfide (CTS) thin films were grown by co-evaporation at different Cu/Sn atomic ratios. • Smooth Cu{sub 2}SnS{sub 3} layers with large grains are obtained at Cu/Sn ⩾ 1.5 and T ⩾ 350 °C. • At 450 °C, the cubic Cu{sub 2}SnS{sub 3} phase changes to tetragonal phase. • Cu{sub 2}SnS{sub 3} presents suitable optical and electrical properties for use as photovoltaic absorbers. - Abstract: Copper tin sulfide thin films have been grown on soda-lime glass substrates from the elemental constituents by co-evaporation. The synthesis was performed at substrate temperatures of 350 °C and 450 °C and different Cu/Sn ratios, adjusting the deposition time in order to obtain thicknesses above 1000 nm. The evolution of the morphological, structural, chemical, optical and electrical properties has been analyzed as a function of the substrate temperature and the Cu/Sn ratio. For the samples with Cu/Sn ⩽ 1, Cu{sub 2}Sn{sub 3}S{sub 7} and Cu{sub 2}SnS{sub 3} have been observed by XRD. Increasing the Cu/Sn to 1.5, the Cu{sub 2}SnS{sub 3} phase was the majority, being the formation completed at Cu/Sn ratio around 2. The increment of the substrate temperature leads to a change of cubic structure to tetragonal of the Cu{sub 2}SnS{sub 3} phase. The chemical treatment with KCN was effective to eliminate CuS excess detected in the samples with Cu/Sn > 2.2. The samples with Cu{sub 2}SnS{sub 3} structure show a band gap energy increasing from 0.9 to 1.25 eV and an electrical resistivity decreasing from 7 ∗ 10{sup −2} Ω cm to 3 ∗ 10{sup −3} Ω cm when the Cu/Sn atomic ratio increases from 1.5 to 2.2.

  1. Direct patterning of Cu microstructures using femtosecond laser-induced CuO nanoparticle reduction

    Cu-based microstructures were directly patterned using femtosecond laser-induced CuO nanoparticle reduction. CuO nanoparticle-based solution, consisting CuO nanoparticles, ethylene glycol, and polyvinylpyrrolidone, was spin-coated on glass substrates. Microstructures were formed by irradiating focused femtosecond laser pulses. Cu and Cu2O peak intensities were observed in the X-ray diffraction (XRD) spectra of the microstructures. Compared to single scan, the Cu peak intensities increased by double scan. This result suggests that double scan is effective for increasing the amount of Cu from CuO nanoparticle solution. Cu- and Cu2O-rich microstructures were formed selectively by controlling laser irradiation conditions. The resistivity of the Cu-rich microstructures was estimated by 528 µΩ m which was 104 times and 10 times larger than the values of Cu and Cu2O, respectively. This large resistivity could be applied for microheaters. (author)

  2. Direct patterning of Cu microstructures using femtosecond laser-induced CuO nanoparticle reduction

    Arakane, Shun; Mizoshiri, Mizue; Hata, Seiichi

    2015-06-01

    Cu-based microstructures were directly patterned using femtosecond laser-induced CuO nanoparticle reduction. CuO nanoparticle-based solution, consisting CuO nanoparticles, ethylene glycol, and polyvinylpyrrolidone, was spin-coated on glass substrates. Microstructures were formed by irradiating focused femtosecond laser pulses. Cu and Cu2O peak intensities were observed in the X-ray diffraction (XRD) spectra of the microstructures. Compared to single scan, the Cu peak intensities increased by double scan. This result suggests that double scan is effective for increasing the amount of Cu from CuO nanoparticle solution. Cu- and Cu2O-rich microstructures were formed selectively by controlling laser irradiation conditions. The resistivity of the Cu-rich microstructures was estimated by 528 µΩ m which was 104 times and 10 times larger than the values of Cu and Cu2O, respectively. This large resistivity could be applied for microheaters.

  3. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore.

    Measday, Vivien; Hailey, Dale W; Pot, Isabelle; Givan, Scott A; Hyland, Katherine M; Cagney, Gerard; Fields, Stan; Davis, Trisha N; Hieter, Philip

    2002-01-01

    The budding yeast kinetochore is composed of an inner and outer protein complex, which binds to centromere (CEN) DNA and attaches to microtubules. We performed a genetic synthetic dosage lethality screen to identify novel kinetochore proteins in a collection of chromosome transmission fidelity mutants. Our screen identified several new kinetochore-related proteins including YLR381Wp/Ctf3p, which is a member of a conserved family of centromere-binding proteins. Ctf3p interacts with Mcm22p, Mcm16p, and the outer kinetochore protein Ctf19p. We used chromatin immunoprecipitation to demonstrate that Ctf3p, Mcm22p, and Mcm16p bind to CEN DNA in a Ctf19p-dependent manner. In addition, Ctf3p, Mcm22p, and Mcm16p have a localization pattern similar to other kinetochore proteins. The fission yeast Ctf3p homolog, Mis6, is required for loading of a CENP-A centromere specific histone, Cnp1, onto centromere DNA. We find however that Ctf3p is not required for loading of the budding yeast CENP-A homolog, Cse4p, onto CEN DNA. In contrast, Ctf3p and Ctf19p fail to bind properly to the centromere in a cse4-1 mutant strain. We conclude that the requirements for CENP-A loading onto centromere DNA differ in fission versus budding yeast. PMID:11782448

  4. GMI in FeCuNbSiB/Cu multilayers

    Correa, M.A. [Departamento de Fisica, CCNE, UFSM, 97105-900, Santa Maria, RS (Brazil)]. E-mail: mmacorrea@gmail.com; Viegas, A.D.C. [Departamento de Fisica, CCNE, UFSM, 97105-900, Santa Maria, RS (Brazil); Silva, R.B. da [Departamento de Fisica, CCNE, UFSM, 97105-900, Santa Maria, RS (Brazil); Andrade, A.M.H. de [Departamento de Fisica, CCNE, UFSM, 97105-900, Santa Maria, RS (Brazil); Sommer, R.L. [Centro Brasileiro de Pesquisas Fisicas, 22290-180, Rio de Janeiro, RJ (Brazil)

    2006-10-01

    Very high magnetoimpedance (MI) measured at frequencies up to 1.8 GHz in single and multilayered thin films with composition Fe{sub 73.5}Cu{sub 1}Nb{sub 3}Si{sub 13.5}B{sub 9} and (Fe{sub 73.5}Cu{sub 1}Nb{sub 3}Si{sub 13.5}B{sub 9}+Cu) are reported. The magnetic properties of both systems are also compared. MI ratio as high as 300% for the multilayered samples were obtained.

  5. Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver.

    Zhang, Wenxiang; Wang, Peng; Chen, Siyu; Zhang, Zhao; Liang, Tingming; Liu, Chang

    2016-06-01

    Circadian clocks orchestrate daily oscillations in mammalian behaviors, physiology, and gene expression. MicroRNAs (miRNAs) play a crucial role in fine-tuning of the circadian system. However, little is known about the direct regulation of the clock genes by specific miRNAs. In this study, we found that miR-27b-3p exhibits rhythmic expression in the metabolic tissues of the mice subjected to constant darkness. MiR-27b-3p's expression is induced in livers of unfed and ob/ob mice. In addition, the oscillation phases of miR-27b-3p can be reversed by restricted feeding, suggesting a role of peripheral clock in regulating its rhythmicity. Bioinformatics analysis indicated that aryl hydrocarbon receptor nuclear translocator-like (also known as Bmal1) may be a direct target of miR-27b-3p. Luciferase reporter assay showed that miR-27b-3p suppressed Bmal1 3' UTR activity in a dose-dependent manner, and mutagenesis of their binding site abolished this suppression. Furthermore, overexpression of miR-27b-3p dose-dependently reduced the protein expression levels of BMAL1 and impaired the endogenous BMAL1 and gluconeogenic protein rhythmicity. Collectively, our results suggest that miR-27b-3p plays an important role in the posttranscriptional regulation of BMAL1 protein in the liver. MiR-27b-3p may serve as a novel node to integrate the circadian clock and energy metabolism.-Zhang, W., Wang, P., Chen, S., Zhang, Z., Liang, T., Liu, C. Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver. PMID:26919869

  6. Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

    Gehani, Simmi Suman; Agrawal-Singh, Shuchi; Dietrich, Nikolaj;

    2010-01-01

    phosphorylation, and displacement of PcG proteins, lead to gene activation. We present evidence that the H3K27me3S28 phosphorylation is functioning in response to stress signaling, mitogenic signaling, and retinoic acid (RA)-induced neuronal differentiation. We propose that MSK-mediated H3K27me3S28...

  7. Produktion und Freisetzung von L-Glycerol-3-Phosphat (L-G3P) mit genetisch modifizierten Stämmen von Saccharomyces cerevisiae

    Popp, Almut

    2008-01-01

    L-G3P ist ein intrazelluläres phosphoryliertes Stoffwechselzwischenprodukt und zählte als solches bisher nicht zur Produktpalette von Hefe-Fermentationen. Um L-G3P als Baustein für die enzymatische Synthese von Monosacchariden und für andere Anwendungen zu gewinnen, wurden Bedingungen gesucht, unter denen ein S. cerevisiae-Produktionsstamm mit ausgeschalteter Glycerol-3-Phosphatase (gpp1/2) und Überexpression der cytosolischen Glycerol-3-Phosphat-Dehydrogenase (GPD1) gleichzeitig gute L-G3P-P...

  8. Measurement of the photoionization cross-section of the 3p{sup 2}P{sub 1/2,3/2} excited levels of sodium

    Amin, N.; Mahmood, S.; Anwar-ul-Haq, M.; Riaz, M.; Baig, M.A. [Quaid-i-Azam Univ., Atomic and Molecular Physics Lab., Dept. of Physics, Islamabad (Pakistan)

    2006-01-15

    The photoionization cross-section and number density of the 3p{sup 2}P(1/2,3/2) excited levels of sodium have been measured as a function of the laser energy using two-step laser excitation in conjunction with a thermionic diode working in the space charge limited mode. Employing the saturation technique, the cross-sections for the 3p{sup 2}P(1/2) and 3p{sup 2}P(3/2) levels are determined as 2.16 (43) Mb and 3.74 (74) Mb respectively. (authors)

  9. Fabrication and characterization of nanostructured Fe3S4, an isostructural compound of half-metallic Fe3O4

    Li, Peng

    2015-06-10

    High-purity, well-crystallized spinel Fe3S4 nanoplatelets were synthesized by the hydrothermal method, and the saturation magnetic moment of Fe3S4 was measured at 1.83 μB/f.u. The temperature-dependent resistivity of Fe3S4 was metallic-like for T < 180 K: room-temperature resistivity was measured at 7.711 × 103  μΩ cm. The anomalous Hall conductivity of Fe3S4 decreased with increasing longitudinal conductivity, in sharp contrast with the accepted theory of the anomalous Hall effect in a dirty-metal regime. Furthermore, negligible spin-dependent magnetoresistance was observed. Band structure calculations confirmed our experimental observations that Fe3S4 is a metal and not a half metal as expected.

  10. The Copernicus Climate Change Service (C3S): Open Access to a Climate Data Store

    Thepaut, Jean-Noel; Dee, Dick

    2016-04-01

    In November 2014, The European Centre for Medium-range Weather Forecasts (ECMWF) signed an agreement with the European Commission to deliver two of the Copernicus Earth Observation Programme Services on the Commission's behalf. The ECMWF delivered services - the Copernicus Climate Change Service (C3S) and Atmosphere Monitoring Service (CAMS) - will bring a consistent standard to how we monitor and predict atmospheric conditions and climate change. They will maximise the potential of past, current and future earth observations - ground, ocean, airborne, satellite - and analyse these to monitor and predict atmospheric conditions and in the future, climate change. With the wealth of free and open data that the services provide, they will help business users to assess the impact of their business decisions and make informed choices, delivering a more energy efficient and climate aware economy. These sound investment decisions now will not only stimulate growth in the short term, but reduce the impact of climate change on the economy and society in the future. C3S is in its proof of concept phase and through its Climate Data Store will provide • global and regional climate data reanalyses; • multi-model seasonal forecasts; • customisable visual data to enable examination of wide range of scenarios and model the impact of changes; • access to all the underlying data, including climate data records from various satellite and in-situ observations. In addition, C3S will provide key indicators on climate change drivers (such as carbon dioxide) and impacts (such as reducing glaciers). The aim of these indicators will be to support European adaptation and mitigation policies in a number of economic sectors. At the heart of the Service is the provision of open access to a one stop shop (the Climate Data Store) of climate data and modelling, analysing more than 20 Essential Climate Variables to build a global picture of our past, present and future climate and developing

  11. Cu, Cu-Cu2O core-shell, and hollow Cu2O nanodendrites: Structural evolution and reverse surface-enhanced Raman scattering

    Cu-Cu2O core-shell nanodendrites and Cu2O hollow dendrites were prepared for the first time by distinct heat treatments of single crystalline Cu nanodendrites synthesized by the proposed low toxicity electrodeposition route. The crystallographic directions of the nanodendrites were studied by high resolution transmission electron microscopy and the orientation relations of Cu2O and Cu from the Cu-Cu2O core-shell nanodendrites were found to be Cu(1 1 1)[0 1-bar 1]||Cu2O(0 0 1)[1 1-bar 0]. Hollow Cu2O nanodendrites were characterized as quasi-single crystalline structures, which are proposed to form via the evaporation and escape of Cu in the core part of nanodendrites during specific heat treatments. Raman spectra show reverse surface-enhanced Raman scattering (SERS) effects for Cu and Cu-Cu2O core-shell nanodendrites in detecting absorbed 4-aminobenzenethiol molecules under 633 and 532 nm excitation. The Cu-Cu2O core-shell dendrites show an even stronger SERS effect than Cu dendrites under 532 nm excitation, which is attributed to near resonance excitations and shape effects. Contact angle measurements show the contact angles of Cu, Cu-Cu2O, and hollow Cu2O nanodendrites are 20.9o, 133.2o, and 104.9o, respectively. These diverse nanodendrites not only provide abundant directions for academic research, but are also promising for sensing, self-cleaning, electronic devices and drug delivery applications.

  12. Cu-Cr Literature Review

    Need, Ryan F. [Los Alamos National Laboratory

    2012-08-09

    Cu-Cr alloys are part of a class of face-centered cubic (FCC)-body-centered cubic (BCC) composites that includes similar alloys, such as Cu-Nb and Cu-Ta. When heavily deformed, these FCC-BCC materials create 'in situ' composites with a characteristic structure-nanoscale BCC filaments in a ductile FCC matrix. The strength of these composites is vastly greater than predicted by the rule of mixtures, and has been shown to be inversely proportional to the filament spacing. Lower raw materials costs suggest that Cu-Cr alloys may offer more economical solution to high-strength, high-conductivity wire than either their Nb or Ta counterparts. However, Cr is also more brittle and soluble in Cu than Nb or Ta. These qualities necessitate thermal treatments to remove solute atoms from the Cu matrix, improve conductivity, and maintain the ductility of the Cr filaments. Through the use of different thermomechanical processing routes or the addition of select dopants, alloys with strength in excess of 1 GPa at 70% IACS have been achieved. To date, previous research on Cu-Cr alloys has focused on a relatively small number of alloy compositions and processing methods while the effects of dopants and ageing treatments have only been studied independently. Consequently, there remains considerable opportunity for the development and optimization of these alloys as a leading high-strength, high-conductivity material.

  13. Cu-ZSM-5, Cu-ZSM-11, and Cu-ZSM-12 Catalysts for Direct NO Decomposition

    Kustova, Marina; Kustov, Arkadii; Christiansen, Sofie E.;

    2006-01-01

    Cu-ZSM-5 has for many years been recognized as a unique catalyst for direct NO decomposition. Here, it is discovered that both Cu-ZSM-11 and Cu-ZSM-12 are about twice as active as Cu-ZSM-5. This difference is attributed to the active sites located almost exclusively in the straight zeolite pores...

  14. Possible mechanism of superconductivity in CuO-Cu interface

    Amelin, I I

    2002-01-01

    The CuO two-dimensional lattice consisting of the Cu sup 2 sup + and O sup 1 sup - ions which form the narrow partially filled two-dimensional zone is apparently formed in the CuO-Cu interface on the copper oxide surface. In this case formation of local electron pairs (LEP) is possible in the plane oxygen subsystem due to the Shubin-Vonsovskii conditions. In this approximation rough evaluation of the LEP formation temperature results in the T* approx 10 sup 4 K value. The temperature of the initial Bose-Einstein condensation by the concentration in the interface layer n approx 1.6 x 10 sup 2 sup 0 cm sup - sup 3 and the carriers effective mass m* approx m sub e may have the value of T sub c approx 1000 K. The obtained evaluation of the T sub c temperature corresponds by the values order to the experimental value

  15. JRC Copernicus Climate Change Service (C3S) F4P platform

    Gobron, Nadine; Adams, Jennifer; Cappucci, Fabrizio; Lanconelli, Christian; Morgan, Olivier; Mota, Bernado; Robustelli, Monica

    2016-07-01

    This paper presents the Climate Change Copernicus Service (C3S) fitness-for-purpose (F4P) platform which is actually developed at the Joint Research Centre. This platform aims at monitoring several Earth Observation (EO) land Essential Climate Variables (ECVs) accuracies by assessing their compliance against GCOS criteria. One component uses a quality 3-D radiative transfer modelled-based approach for assessing 1) the ground-based measurements protocols traditionally used to validate EO products and 2) several space retrieval algorithms. In the second module, we propose an automatic review of their quality at global and regional scale and present new metrics, such as the Gamma Index, to check GCOS criteria compliance, including the stability assessment.

  16. Controlled Sonar Exposure Experiments on Cetaceans in Norwegian Waters: Overview of the 3S-Project.

    Lam, Frans-Peter A; Kvadsheim, Petter H; Miller, Patrick J O; Tyack, Peter L; Ainslie, Michael A; Curé, Charlotte; Kleivane, Lars; Sivle, Lise Doksæter; van Ijsselmuide, Sander P; Visser, Fleur; von Benda-Beckmann, Alexander M; Wensveen, Paul J; Dekeling, René P A

    2016-01-01

    In mitigating the risk of sonar operations, the behavioral response of cetaceans is one of the major knowledge gaps that needs to be addressed. The 3S-Project has conducted a number of controlled exposure experiments with a realistic sonar source in Norwegian waters from 2006 to 2013. In total, the following six target species have been studied: killer, long-finned pilot, sperm, humpback, minke, and northern bottlenose whales. A total of 38 controlled sonar exposures have been conducted on these species. Responses from controlled and repeated exposure runs have been recorded using acoustic and visual observations as well as with electronic tags on the target animal. So far, the first dose-response curves as well as an overview of the scored severity of responses have been revealed. In this paper, an overview is presented of the approach for the study, including the results so far as well as the current status of the ongoing analysis. PMID:26611008

  17. Cell Monitoring and Manipulation Systems (CMMSs based on Glass Cell-Culture Chips (GC3s

    Sebastian M. Buehler

    2016-06-01

    Full Text Available We developed different types of glass cell-culture chips (GC3s for culturing cells for microscopic observation in open media-containing troughs or in microfluidic structures. Platinum sensor and manipulation structures were used to monitor physiological parameters and to allocate and permeabilize cells. Electro-thermal micro pumps distributed chemical compounds in the microfluidic systems. The integrated temperature sensors showed a linear, Pt1000-like behavior. Cell adhesion and proliferation were monitored using interdigitated electrode structures (IDESs. The cell-doubling times of primary murine embryonic neuronal cells (PNCs were determined based on the IDES capacitance-peak shifts. The electrical activity of PNC networks was detected using multi-electrode arrays (MEAs. During seeding, the cells were dielectrophoretically allocated to individual MEAs to improve network structures. MEA pads with diameters of 15, 20, 25, and 35 µm were tested. After 3 weeks, the magnitudes of the determined action potentials were highest for pads of 25 µm in diameter and did not differ when the inter-pad distances were 100 or 170 µm. Using 25-µm diameter circular oxygen electrodes, the signal currents in the cell-culture media were found to range from approximately −0.08 nA (0% O2 to −2.35 nA (21% O2. It was observed that 60-nm thick silicon nitride-sensor layers were stable potentiometric pH sensors under cell-culture conditions for periods of days. Their sensitivity between pH 5 and 9 was as high as 45 mV per pH step. We concluded that sensorized GC3s are potential animal replacement systems for purposes such as toxicity pre-screening. For example, the effect of mefloquine, a medication used to treat malaria, on the electrical activity of neuronal cells was determined in this study using a GC3 system.

  18. Observation of strong electron correlations in YBa/sub 2/Cu/sub 3/O/sub 7-/ /sub delta/ by hv-dependent photoelectron spectroscopy

    Thiry, P.; Rossi, G.; Petroff, Y. and others

    1988-01-01

    We present photoemission spectra from single-phase YBa/sub 2/Cu/sub 3/O/sub 7-/ /sub delta/ which have been measured in the photon energy range (17(division)130)eV, at T=80 K, T=300 K and intermediate temperatures using synchrotron radiation. Intense satellites associated with the Cu3d and O2p bands are observed to undergo resonances at the Cu3p and O2s core level excitation thresholds, respectively, indicating the presence of holes in the Cu and O hybrid bands on both Cu and O sites. The strong correlation effects for the valence electrons suggest that one-electron calculations may not be appropriate for a detailed description of the electronic properties of this material.

  19. Electron-energy-loss spectroscopy of KxC60 and K-halides: comparison in the K-3p excitation region

    上野, 啓司; 斉木, 幸一朗; 小間, 篤

    2001-01-01

    We have investigated the electronic structure of KxC60 (x = 0-6) using low-energy electron energy loss spectroscopy (LEELS), especially focusing on the K-3p core-electron excitation spectra. It is found that the structure of the K-3p-excitation spectrum of KxC60 quite differs from that of KCI. Furthermore, the K-3p-excitation LEELS of K3C60 has been revealed to be different from that of K6C60. K-3p electrons are excited into K-4s- and K-3d-derived empty states in both KxC60 and KCI, but in th...

  20. Synthesis and Characterization of Organophosphazene Polyoxotungstate [(N3P3)(SiW11O39H2)3]12-

    Jian GONG; Chang Lu SHAO; Lun Yu QU

    2004-01-01

    A new organophosphazene polyoxotungstate, [(N3P3)(SiW11O39H2)3]12-, has been prepared by reaction of hexachlorocyclotriphosphazene with undecatungstosilicate, and characterized by elemental analysis, infrared spectroscopy, and multinuclear 31P NMR.

  1. T3P as an efficient cyclodehydration reagent for the one-pot synthesis of 2-amino-1,3,4-oxadiazoles

    Andivelu Ilangovan; Shanmugasundar Saravanakumar; Siddappa Umesh

    2015-05-01

    A scalable and environmentally friendly one-pot method for the synthesis of 2-amino-1,3,4-oxadiazoles from acylhydrazides and isocyanates has been achieved with propane phosponic anhydride (T3P) acting as cyclodehydrating reagent.

  2. Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae

    A soluble variant of the monoglyceride lipase Yju3p was successfully expressed, purified and crystallized. Diffraction data were collected to 2.4 Å resolution. The protein Yju3p is the orthologue of monoglyceride lipases in the yeast Saccharomyces cerevisiae. A soluble variant of this lipase termed s-Yju3p (38.3 kDa) was generated and purified to homogeneity by affinity and size-exclusion chromatography. s-Yju3p was crystallized in a vapour-diffusion setup at 293 K and a complete data set was collected to 2.4 Å resolution. The crystal form was orthorhombic (space group P212121), with unit-cell parameters a = 77.2, b = 108.6, c = 167.7 Å. The asymmetric unit contained four molecules with a solvent content of 46.4%

  3. Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae

    Rengachari, Srinivasan; Aschauer, Philipp; Sturm, Christian; Oberer, Monika, E-mail: m.oberer@uni-graz.at [University of Graz, Humboldtstrasse 50/3, 8010 Graz (Austria)

    2015-01-28

    A soluble variant of the monoglyceride lipase Yju3p was successfully expressed, purified and crystallized. Diffraction data were collected to 2.4 Å resolution. The protein Yju3p is the orthologue of monoglyceride lipases in the yeast Saccharomyces cerevisiae. A soluble variant of this lipase termed s-Yju3p (38.3 kDa) was generated and purified to homogeneity by affinity and size-exclusion chromatography. s-Yju3p was crystallized in a vapour-diffusion setup at 293 K and a complete data set was collected to 2.4 Å resolution. The crystal form was orthorhombic (space group P2{sub 1}2{sub 1}2{sub 1}), with unit-cell parameters a = 77.2, b = 108.6, c = 167.7 Å. The asymmetric unit contained four molecules with a solvent content of 46.4%.

  4. Cu-62, Cu-64 and Cu-66 production with 4.2 MeV deuterons

    Full text: The natural copper irradiation with deuterons produces the Cu-62, Cu-64 and Cu-66 radionuclides. Of two radioisotopes, those with deficiencies in neutrons, are applied in nuclear medicine diagnostic processes, mainly for the nuclear characteristic of the decay modes. The positron emitters, of short life mean Cu-62 (9.1 min, β+) and Cu(12.7 h), are radionuclides applied in radio pharmacological preparation for brain, core, blood flux studies. The radiochemical process consists in the de solution of the irradiated metallic copper target, in acid medium. The result solution, can be neutralized with a base or a buffer at wished pH. Using a deuteron beam of 4,2 ± 0,1 MeV energy has been obtained total yields of 1,103 ± 0,011 μCl/μAh medium for 62 Cu and of 0,148 ± 0,015 μCl/μAh for 64 Cu

  5. Measurement of electron-impact excitation into the 3p54p levels of argon using Fourier-transform spectroscopy

    To experimentally determine electron-impact excitation cross sections with the optical method, it is necessary to measure all transitions out of a level (the apparent cross sections), as well as the cascades into the level. In the case of the ten 3p54p levels of argon, the emissions to lower levels lie in the visible and near infrared (660 endash 1150 nm) and are hence observable with a monochromator endash photomultiplier-tube (PMT) system. A Fourier-transform spectrometer (FTS) allows us to measure the previously uninvestigated cascades that lie in the infrared. For the incident electron energy range between onset and 300 eV, we have measured the apparent cross sections with a monochromator-PMT system, and the cascade cross sections with a weak emission FTS system. The magnitude of both the apparent and cascade cross sections increases with target gas pressure due to radiation trapping effects. By subtracting the cascade contributions from the apparent cross sections, we have determined the direct cross sections and verified that they do not vary with pressure in the 0.5 endash 4-mTorr pressure range considered here. copyright 1998 The American Physical Society

  6. Preparation and H+ response mechanism of W/WO3 pH electrode by sol-gel method

    CHEN Dong-chu; FU Chao-yang; ZHEN Jia-sheng; WANG Zhe

    2005-01-01

    A method of sol-gel for preparing a W/WO3 pH electrode was presented. H+ response characteristics,such as response range, response sensitivity, response time were investigated. The effect of heat-treatment on response linear relation was discussed. The influences of interfered ions and solution temperatures were also taken into consideration. Many kinds of determination technology, such as TG, DSC, IR, SEM, AFM,XPS, XRD were used to characterize the film. The results show that the film appears in crack dried-mud, and the film is composed of ature; the W+6 in the electrode film transfers to W+5 in the course of H+ response; the H+ response course is controlled by the H+ diffusion from the solution to the WO3 crystalline, which is indicated in the EIS spectra; the best heat-treatment temperature is 200 ℃, and at this temperature, the electrode has an H+ response sensitivity of 52mV/pH.

  7. (2p/sup 2/)/sup 3/P state of H/sup -/ and the convergence of the CI series

    Jauregui, R.; Bunge, C.F.

    1979-12-01

    A sequence of increasingly accurate configuration interaction (CI) wave functions is used to discuss binding and the convergence of the CI series for the (2p/sup 2/)/sup 3/P state of H/sup -/. We get an upper bound energy E/sub u/=-0.1 253 547 166 a.u.(H), the lowest yet obtained, lying within an estimated 0.4 ..mu..hartree from the exact eigenvalue of Schroedinger's nonrelativistic equation. The angular energy limits define angular energy increments ..delta..E/sub l/ which follows the formula ..delta..E/sub l/approx. =0.18 (l+1/2)/sup -7/a.u. for l> or =4. Five or eighty per cent of binding is obtained with a three-term Psi=c/sub 1/(2p)/sup 2/+c/sub 2/(2p')/sup 2/+c/sub 3/ (3d)/sup 2/ depending on whether the 2p,2p', and 3d orbitals are energy optimized STO's or accurate natural orbitals, respectively.

  8. Kinetic isotope effect in the reaction of O(3P) with H2, D2, and HD

    The reaction of O(3P)+H2, D2, and HD was studied by the flash photolysis-resonance fluorescence method. The rate constants k/sub XY/(T) were measured over the temperature ranges 297--471 K for XY = H2, 422--472 K for D2, and 422--473 K for HD. Above 400 K k2 are in excellent agreement with earlier flow measurements, but below this temperature most of the flow data are systematically lower. A small deviation from the Arrhenius function was observed for k2 at 297 K. Our measurements of k2 are in excellent agreement with the results of Westenberg and deHaas and differ from those Clyne and Thrush. The measured values of k/sub HD/ equal the arithmetic mean of k2 and k2 within experimental error. A detailed comparison is made between the present results and the CEQB calculations of Bowman, Wagner, Walch, and Dunning and the ICVT/LAG calculations of Garrett and Truhlar. Good overall agreement is obtained with both theories

  9. Semirigid vibrating rotor target calculation for reaction O(3p)+CH4 →CH3+OH

    LIU; Xinguo; BAI; Lihua; ZHANG; Qinggang

    2004-01-01

    The time-dependent quantum dynamics calculation for reaction O(3p)+CH4→ CH3+OH is made, using of the semirigid vibrating rotor target (SVRT) model and the time-dependent wave packet (TDWP) method. The corresponding reaction probabilities of different initial states are provided. From the calculation of initial rovibrational state j= 0,v= 0, 1, we can see that the excitation of the H-CH3 stretching vibration gives significant enhancement of reaction probability and the reaction threshold decreases dramatically with the enhancement of the vibrating excitation, which indicates that the vibrating energy of reagent molecules contributes a lot to the molecular collision. As for the calculation of reaction probability of state v= 0, j= 0,1,2,3, the results show that the reaction probability rises significantly with the enhancement of rotational quantum number j while the reaction threshold has no changes. The spatial steric effect of the title reaction is studied and analyzed too after the calculation of reaction probability of states j= 5, k= 0-2, n= 0 and j=5, k=2, n=0-2 is made.

  10. SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation

    Wainwright, Elanor N; Jorgensen, Joan S; Kim, Youngha; Truong, Vy; Bagheri-Fam, Stefan; Davidson, Tara; Svingen, Terje; Fernandez-Valverde, Selene L; McClelland, Kathryn S; Taft, Ryan J; Harley, Vincent R; Koopman, Peter; Wilhelm, Dagmar

    2013-01-01

    differentiation. These microRNAs are expressed in a sexually dimorphic pattern as the primordial XY gonad differentiates into a testis, with strong expression in Sertoli cells. In vivo, ectopic expression of pri-miR-202 in XX gonads did not result in molecular changes to the ovarian determination pathway...... promoter that is sufficient to drive expression in XY but not XX fetal gonads ex vivo. Mutation of SOX9 and SF1 binding sites reduced ex vivo transactivation of the pri-miR-202 promoter, demonstrating that pri-miR-202 may be a direct transcriptional target of SOX9/SF1 during testis differentiation. Our....... Expression of the primary transcript of miR-202-5p/3p remained low in XY gonads in a conditional Sox9-null mouse model, suggesting that pri-miR-202 transcription is downstream of SOX9, a transcription factor that is both necessary and sufficient for male sex determination. We identified the pri-miR-202...

  11. A common variant of PNPLA3 (p.I148M is not associated with alcoholic chronic pancreatitis.

    Jonas Rosendahl

    Full Text Available BACKGROUND: Chronic pancreatitis (CP is an inflammatory disease that in some patients leads to exocrine and endocrine dysfunction. In industrialized countries the most common aetiology is chronic alcohol abuse. Descriptions of associated genetic alterations in alcoholic CP are rare. However, a common PNPLA3 variant (p.I148M is associated with the development of alcoholic liver cirrhosis (ALC. Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M possibly influences the development of alcoholic CP. METHODS: Using melting curve analysis we genotyped the variant in 1510 patients with pancreatitis or liver disease (961 German and Dutch alcoholic CP patients, 414 German patients with idiopathic or hereditary CP, and 135 patients with ALC. In addition, we included in total 2781 healthy controls in the study. RESULTS: The previously published overrepresentation of GG-genotype was replicated in our cohort of ALC (p-value <0.0001, OR 2.3, 95% CI 1.6-3.3. Distributions of genotype and allele frequencies of the p.I148M variant were comparable in patients with alcoholic CP, idiopathic and hereditary CP and in healthy controls. CONCLUSIONS: The absence of an association of PNPLA3 p.I148M with alcoholic CP seems not to point to a common pathway in the development of alcoholic CP and alcoholic liver cirrhosis.

  12. Analysis of a ribonuclease H digestion of N3'-->P5' phosphoramidate-RNA duplexes by capillary gel electrophoresis.

    DeDionisio, L; Gryaznov, S M

    1995-07-01

    Phosphodiester oligonucleotides (ODNs) and their analogs are presently being investigated as potential antisense therapeutics in the treatment of viral infections and various forms of cancer. here, we would like to report results from an investigation of activity for a ribonuclease H (RNase H) mediated RNA digestion assay in the duplexes formed by an ODN or the ODN analog, N3'-->P5' phosphoramidate (3'-phosphoramidate), and complimentary RNA strands. Capillary gel electrophoresis (CGE) proved to be an effective method for determining RNA hydrolysis in the presence of RNase H. RNA and an ODN or RNA and a 3'-phosphoramidate were hybridized in a Tris-HCl, MgCl2 buffer at room temperature (RT) and incubated with RNase H. Digestions were carried out at RT or at 37 degrees C. Control samples were unhybridized RNA with RNase H, RNA without RNase H, and duplexes (RNA-ODN or 3'-phosphoramidate) without RNase H. All controls were incubated in Tris-HCl, MgCl2 buffer, and sample aliquots were analyzed at various time intervals. A homodecamer, (dT)10, was used as an internal standard to determine the relative migration time of the RNA strand. The final digestion products for the duplexes and the various controls were monitored by CGE. In addition, polyacrylamide gel electrophoresis (PAGE) was used in conjunction with Stains-All (staining) and a densitometric analysis to verify CGE results. PMID:7581876

  13. Remote frequency measurement of the 1S0-3P1 transition in laser cooled 24Mg

    Friebe, J; Wübbena, T; Pape, A; Kelkar, H; Ertmer, W; Terra, O; Sterr, U; Weyers, S; Grosche, G; Schnatz, H; Rasel, E M

    2011-01-01

    We perform Ramsey-Borde spectroscopy on laser cooled magnesium atoms in free fall to measure the 1S0-3P1 intercombination transition frequency. The measured value of 655 659 923 839 730 (48) Hz is consistent with our former atomic beam measurement. We improve upon the fractional accuracy of the previous measurement by more than an order of magnitude to 7 x 10^-14. The magnesium frequency standard was referenced to a fountain clock of the Physikalisch Technische Bundesanstalt (PTB) via a phase-stabilized telecom fiber link and its stability characterized for interrogation times up to 8000 s. Our measurement revealed a new systematic effect due to the movement of atoms across the spectroscopy beams. A remarkable property of this effect is the counterintuitive reduction of residual Doppler shift with increasing resolution. Our theoretical model of the atom-light interaction is in agreement with the observed effect and allows us to quantify its contribution in the uncertainty budget.

  14. Formation of deeply bound ultracold Sr_2 molecules by photoassociation near the ^1S + ^3P_1 intercombination line

    Skomorowski, Wojciech; Koch, Christiane P

    2012-01-01

    We predict feasibility of the photoassociative formation of Sr_2 molecules in arbitrary vibrational levels of the electronic ground state based on state-of-the-art ab initio calculations. Key is the strong spin-orbit interaction between the c^3\\Pi_u, A^1\\Sigma_u^+ and B^1\\Sigma_u^+ states. It creates not only an effective dipole moment allowing free-to-bound transitions near the ^1S + ^3P_1 intercombination line but also facilitates bound-to-bound transitions via resonantly coupled excited state rovibrational levels to deeply bound rovibrational levels of the ground X^1\\Sigma_g^+ potential, with v" as low as v"=6. The spin-orbit interaction is responsible for both optical pathways. Therefore, those excited state levels that have the largest bound-to-bound transition moments to deeply bound ground state levels also exhibit a sufficient photoassociation probability, comparable to that of the lowest weakly bound excited state level previously observed by Zelevinsky et al. [Phys. Rev. Lett. 96, 203201 (2006)]. Ou...

  15. Incorporation of trace elements in Portland cement clinker: Thresholds limits for Cu, Ni, Sn or Zn

    This paper aims at defining precisely, the threshold limits for several trace elements (Cu, Ni, Sn or Zn) which correspond to the maximum amount that could be incorporated into a standard clinker whilst reaching the limit of solid solution of its four major phases (C3S, C2S, C3A and C4AF). These threshold limits were investigated through laboratory synthesised clinkers that were mainly studied by X-ray Diffraction and Scanning Electron Microscopy. The reference clinker was close to a typical Portland clinker (65% C3S, 18% C2S, 8% C3A and 8% C4AF). The threshold limits for Cu, Ni, Zn and Sn are quite high with respect to the current contents in clinker and were respectively equal to 0.35, 0.5, 0.7 and 1 wt.%. It appeared that beyond the defined threshold limits, trace elements had different behaviours. Ni was associated with Mg as a magnesium nickel oxide (MgNiO2) and Sn reacted with lime to form a calcium stannate (Ca2SnO4). Cu changed the crystallisation process and affected therefore the formation of C3S. Indeed a high content of Cu in clinker led to the decomposition of C3S into C2S and of free lime. Zn, in turn, affected the formation of C3A. Ca6Zn3Al4O15 was formed whilst a tremendous reduction of C3A content was identified. The reactivity of cements made with the clinkers at the threshold limits was followed by calorimetry and compressive strength measurements on cement paste. The results revealed that the doped cements were at least as reactive as the reference cement.

  16. Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores

    King, Emma M J; Rachidi, Najma; Morrice, Nick; Hardwick, Kevin G.; Stark, Michael J. R.

    2007-01-01

    The spindle checkpoint delays anaphase onset until all chromosomes are correctly attached to microtubules. Ipl1 protein kinase (Aurora B) is required to correct inappropriate kinetochore-microtubule attachments and for the response to lack of tension between sister kinetochores. Here we identify residues in the checkpoint protein Mad3p that are phosphorylated by Ipl1p. When phosphorylation of Mad3p at two sites is prevented, the cell's response to reduced kinetochore tension is dramatically c...

  17. Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores

    King, Emma M J; Rachidi, Najma; Morrice, Nick; Hardwick, Kevin G.; Stark, Michael J. R.

    2007-01-01

    The spindle checkpoint delays anaphase onset until all chromosomes are correctly attached to microtubules. Ipl1 protein kinase (Aurora B) is required to correct inappropriate kinetochore–microtubule attachments and for the response to lack of tension between sister kinetochores. Here we identify residues in the checkpoint protein Mad3p that are phosphorylated by Ipl1p. When phosphorylation of Mad3p at two sites is prevented, the cell’s response to reduced kinetochore tension is dramatically c...

  18. A mixed-valent molybdenum monophosphate with a layer structure: KMo[sub 3]P[sub 2]O[sub 14

    Guesdon, A.; Borel, M.M.; Leclaire, A.; Grandin, A.; Raveau, B. (Universite de Caen (France))

    1994-03-01

    A new mixed-valent molybdenum monophosphate with a layer structure KMo[sub 3]P[sub 2]O[sub 14] has been isolated. It crystallizes in the space group P2[sub 1]/m with a = 8.599 (2) [angstrom], b = 6.392(2) [angstrom], c = 10.602(1) [angstrom], and [beta] = 111.65 (2)[degrees]. The layers [KMo[sub 3]P[sub 2]O[sub 14

  19. miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG.

    Yoo, Je-Ok; Kwak, Seo-Young; An, Hyun-Ju; Bae, In-Hwa; Park, Myung-Jin; Han, Young-Hoon

    2016-07-01

    Epithelial-mesenchymal transition (EMT) is essential for increased invasion and metastasis during cancer progression. Among the candidate EMT-regulating microRNAs that we previously identified, miR-181b-3p was found to induce EMT in MCF7 breast cancer cells, as indicated by an EMT-characteristic morphological change, increased invasiveness, and altered expression of an EMT marker. Transfection with a miR-181b-3p inhibitor reduced the expression of mesenchymal markers and the migration and invasion of highly invasive breast cancer cells. miR-181b-3p induced the upregulation of Snail, a master EMT inducer and transcriptional repressor of E-cadherin, through protein stabilization. YWHAG was identified as a direct target of miR-181b-3p, downregulation of which induced Snail stabilization and EMT phenotypes. Ectopic expression of YWHAG abrogated the effect of miR-181b-3p, including Snail stabilization and the promotion of invasion. In situ hybridization and immunohistochemical analyses indicated that YWHAG expression was inversely correlated with the expression of miR-181b-3p and Snail in human breast cancer tissues. Furthermore, transfection with miR-181b-3p increased the frequency of metastatic nodule formation in the lungs of mice in experimental metastasis assays using MDA-MB-231 cells. Taken together, our data suggest that miR-181b-3p functions as a metastasis activator by promoting Snail-induced EMT, and may therefore be a therapeutic target in metastatic cancers. PMID:27102539

  20. Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway.

    Zheng, Kehong; Zhou, Xinying; Yu, Jinlong; Li, Qiang; Wang, Hui; Li, Mingyi; Shao, Ziyun; Zhang, Feifei; Luo, Yuhao; Shen, Zetao; Chen, Fei; Shi, Fujun; Cui, Chunhui; Zhao, Dachuan; Lin, Zhiqun; Zheng, Wei; Zou, Zhaowei; Huang, Zonghai; Zhao, Liang

    2016-06-28

    The Wnt/β-catenin pathway is known to contribute to colorectal cancer (CRC) progression, although little is known about the contribution of β-catenin on this process. We investigated the role of miR-490-3p, which was recently reported to suppress tumorigenesis through its effect on Wnt/β-catenin signaling. We found that hypermethylation of the miR-490-3p promoter down-regulates miR-490-3p expression in CRC tissue. Gain- and loss-of-function assays in vitro and in vivo reveal that miR-490-3p suppresses cancer cell proliferation by inducing apoptosis and inhibits cell invasiveness by repressing the initiation of epithelial-to-mesenchymal transition (EMT), a key mechanism in cancer cell invasiveness and metastasis. The frequently rearranged in advanced T-cell lymphomas (FRAT1) protein was identified as a direct target of miR-490-3p and contributes to its tumor-suppressing effects. miR-490-3p appears to have an inhibitory effect on β-catenin expression in nuclear fractions of CRC cells, whereas FRAT1 expression is associated with the accumulation of β-catenin in the nucleus of cells, which could be weakened by transfection with miR-490-3p. Our findings suggest that the miR-490-3p/FRAT1/β-catenin axis is important in CRC progression and provides new insight into the molecular mechanisms underlying CRC. They may help to confirm the pathway driving CRC aggressiveness and serve for the development of a novel miRNA-targeting anticancer therapy. PMID:27037061

  1. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore

    Measday, Vivien; Hailey, Dale W.; Pot, Isabelle; Givan, Scott A.; Hyland, Katherine M.; Cagney, Gerard; Fields, Stan; Davis, Trisha N.; Hieter, Philip

    2002-01-01

    The budding yeast kinetochore is composed of an inner and outer protein complex, which binds to centromere (CEN) DNA and attaches to microtubules. We performed a genetic synthetic dosage lethality screen to identify novel kinetochore proteins in a collection of chromosome transmission fidelity mutants. Our screen identified several new kinetochore-related proteins including YLR381Wp/Ctf3p, which is a member of a conserved family of centromere-binding proteins. Ctf3p interacts with Mcm22p, Mcm...

  2. Order-v^4 Relativistic Corrections to Gluon Fragmentation into ^3S_1 Quarkonium

    Bodwin, Geoffrey T; Lee, Jungil

    2013-01-01

    We compute the relativistic corrections to the color-singlet contribution to gluon fragmentation into a J/psi at relative order v^4, making use of the nonrelativistic QCD (NRQCD) factorization approach. The corresponding full-QCD process exhibits infrared divergences that manifest themselves as single and double poles in epsilon in 4-2epsilon dimensions. We isolate the infrared-divergent contributions and treat them analytically. In the matching of full QCD to NRQCD, the pole contributions are absorbed into long-distance NRQCD matrix elements. The renormalizations of the ultraviolet divergences of the long-distance NRQCD matrix elements involve Born and one-loop single-pole counterterm contributions and Born double-pole counterterm contributions. While the order-v^4 contribution enhances the J/psi hadroproduction rate for the color-singlet channel substantially, this contribution is not important numerically in comparison with the color-octet contributions. We also find that the ^3P_J color-octet channel in t...

  3. Study of π+π- transitions from the Υ(3S) and a search for the hb

    We have investigated the transitions Υ(3S)→π+π-Υ(1S), Υ(3S)→π+π-Υ(2S) and the cascade process Υ(3S)→Υ(2S)+X,Υ(2S)→π+π-Υ(1S), both in the exclusive decay mode, with the daughter Υ state decaying into two leptons, and in the inclusive decay mode, with the daughter Υ state decaying hadronically. Results are presented on the branching fractions and properties of the π+π- system. The π+π- invariant-mass spectra for the decays Υ(3S)→π+π-Υ(1S) and Υ(3S)→π+π-Υ(2S) are measured and compared with theoretical predictions. We also present the results of a search for the hb(1 1P1) and Υ(1 3D) states in inclusive Υ(3S) decays, and for the exclusive decay Υ(3S)→ηΥ(1S)

  4. A comparable study of structural and electrical transport properties of Al and Cu nanowires using first-principle calculations

    The structural and quantum transport properties of Al and Cu nanowires with diameters up to 3.6 nm are studied using density functional theory combined with Landauer formalism. Contrary to the classical electronic behavior, the conductance of Al wires is larger than that of Cu. This is mainly attributed to the larger contribution of conductance channels from Al-3p, which is determined by the chemical nature. Meanwhile, the stronger axial contraction of Al wires plays a minor role to conductance. This makes Al wires possible candidate interconnects in integrated circuits

  5. MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes

    Qu, Xiaochen; Chen, Zhongqiang; Fan, Dongwei; Sun, Chuiguo; Zeng, Yan

    2016-01-01

    Ossification of the ligamentum flavum (OLF) is a disorder of heterotopic ossification of spinal ligaments and is the main cause of thoracic spinal canal stenosis. Previous studies suggested that miR-132-3p negatively regulates osteoblast differentiation. However, whether miR-132-3p is involved in the process of OLF has not been investigated. In this study, we investigated the effect of miR-132-3p and its target genes forkhead box O1 (FOXO1), growth differentiation factor 5 (GDF5) and SRY-box 6 (SOX6) on the osteogenic differentiation of ligamentum flavum (LF) cells. We demonstrated that miR-132-3p was down-regulated during the osteogenic differentiation of LF cells and negatively regulated the osteoblast differentiation. Further, miR-132-3p targeted FOXO1, GDF5 and SOX6 and down-regulated the protein expression of these genes. Meanwhile, FOXO1, GDF5 and SOX6 were up-regulated after osteogenic differentiation and the down-regulation of endogenous FOXO1, GDF5 or SOX6 suppressed the osteogenic differentiation of LF cells. In addition, we also found FOXO1, GDF5 and SOX6 expression in the ossification front of OLF samples. Overall, these results suggest that miR-132-3p inhibits the osteogenic differentiation of LF cells by targeting FOXO1, GDF5 and SOX6. PMID:27556448

  6. Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling.

    Fang, Lishan; Cai, Junchao; Chen, Baixue; Wu, Shanshan; Li, Rong; Xu, Xiaonan; Yang, Yi; Guan, Hongyu; Zhu, Xun; Zhang, Le; Yuan, Jie; Wu, Jueheng; Li, Mengfeng

    2015-01-01

    Cancer stem cells (CSCs) are involved in tumorigenesis, tumour recurrence and therapy resistance and Wnt signalling is essential for the development of the biological traits of CSCs. In non-small cell lung carcinoma (NSCLC), unlike in colon cancer, mutations in β-catenin and APC genes are uncommon; thus, the mechanism underlying the constitutive activation of Wnt signalling in NSCLC remains unclear. Here we report that miR-582-3p expression correlates with the overall- and recurrence-free-survival of NSCLC patients, and miR-582-3p has an activating effect on Wnt/β-catenin signalling. miR-582-3p overexpression simultaneously targets multiple negative regulators of the Wnt/β-catenin pathway, namely, AXIN2, DKK3 and SFRP1. Consequently, miR-582-3p promotes CSC traits of NSCLC cells in vitro and tumorigenesis and tumour recurrence in vivo. Antagonizing miR-582-3p potently inhibits tumour initiation and progression in xenografted animal models. These findings suggest that miR-582-3p mediates the constitutive activation of Wnt/β-catenin signalling, likely serving as a potential therapeutic target for NSCLC. PMID:26468775

  7. Acidic phospholipid-independent interaction of Yas3p, an Opi1-family transcriptional repressor of Yarrowia lipolytica, with the endoplasmic reticulum.

    Kobayashi, Satoshi; Tezaki, Satoshi; Horiuchi, Hiroyuki; Fukuda, Ryouichi; Ohta, Akinori

    2015-12-01

    In the n-alkane-assimilating yeast Yarrowia lipolytica, the transcription of ALK1, encoding cytochrome P450, that catalyses n-alkane hydroxylation is activated by a complex composed of Yas1p and Yas2p via a promoter element, ARE1, in response to n-alkanes. An Opi1-family transcription factor, Yas3p, represses the transcription by binding to Yas2p in the nucleus when cultured in glucose-containing medium, but it is localized to the ER, presumably through interaction with acidic phospholipids, phosphatidic acid and/or phospho inositides, when cultured in n-alkane-containing medium. Here, to elucidate the mechanisms regulating the localization of Yas3p, point and deletion mutants of Yas3p were constructed and analysed. The substitution of Trp(360) and Cys(361) by Arg abrogated the localization of Yas3p to the ER and decreased ARE1-mediated transcriptional activation by n-alkane. A Yas3p truncation mutant consisting of residues 259-422 did not bind to acidic phospholipids, but it was localized to the ER in the presence of n-alkane, implying the acidic-phospholipid-independent recruitment of this mutant to the ER in response to n-alkane. The W360R and C361R substitutions in this truncation mutant abolished its localization to the ER. The results suggest that these residues are implicated in the acidic phospholipid-independent interaction of Yas3p to the ER. PMID:26284565

  8. miR-148b-3p promotes migration of Schwann cells by targeting cullin-associated and neddylation-dissociated 1

    Qian, Tian-mei; Zhao, Li-li; Wang, Jing; Li, Ping; Qin, Jing; Liu, Yi-sheng; Yu, Bin; Ding, Fei; Gu, Xiao-song; Zhou, Song-lin

    2016-01-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively adjust gene expression in multifarious biological processes. However, the regulatory effects of miRNAs on Schwann cells remain poorly understood. Previous microarray analysis results have shown that miRNA expression is altered following sciatic nerve transaction, thereby affecting proliferation and migration of Schwann cells. This study investigated whether miR-148b-3p could regulate migration of Schwann cells by directly targeting cullin-associated and neddylation-dissociated 1 (Cand1). Up-regulated expression of miR-148b-3p promoted Schwann cell migration, whereas silencing of miR-148b-3p inhibited Schwann cell migration in vitro. Further experiments confirmed that Cand1 was a direct target of miR-148b-3p, and Cand1 knockdown reversed suppression of the miR-148b-3p inhibitor on Schwann cell migration. These results suggested that miR-148b-3p promoted migration of Schwann cells by directly targeting Cand1 in vitro.

  9. Characterization of transparent conductive delafossite-CuCr1−xO2 films

    In this study, the CuCr1−xO2 films with x = 0.00–0.25 were prepared on a quartz substrate by sol–gel processing. The films were first deposited onto a quartz substrate by spin-coating. The specimens were annealed at 500 °C in air for 1 h and post-annealed in N2 at 700 °C for 2 h. As the films were post-annealed in N2, a pure delafossite-CuCrO2 phase appeared in the CuCr1−xO2 films below x = 0.20. However, an additional CuO phase appeared at x = 0.25. The pure delafossite-CuCrO2 phase can exist within x ≤ 0.20 in CuCr1−xO2 films. The binding energies of Cu-2p3/2 and Cr-2p3/2 in the CuCr1−xO2 films with the pure delafossite-CuCrO2 phase were 932.1 ± 0.2 eV and 576.0 ± 0.2 eV, respectively. The surface exhibited elongated grain features when the pure delafossite-CuCrO2 phase was present in the CuCr1−xO2 films. The maximum transmittance of the CuCr1−xO2 films with the pure delafossite-CuCrO2 phase was approximately 80%, which moved toward the visible region with the increasing x-value. The film absorption edges were observed at 400 nm, which were sharper with the increasing x-value. The optical bandgaps of CuCr1−xO2 films with the pure delafossite-CuCrO2 phase were approximately 3.0 eV. The electrical conductivity of CuCr1−xO2 films with the pure delafossite-CuCrO2 phase was 1.1 × 10−3 S cm−1 (x = 0.00), and increased to 0.16 S cm−1 (x = 0.20). The corresponding carrier concentration of CuCr1−xO2 films with the pure delafossite-CuCrO2 phase was 2.8 × 1014 cm−3 (x = 0.00), and markedly increased to 1.8 × 1016 cm−3 (x = 0.20). The Cr-deficient condition in delafossite-CuCrO2 films enhances film electrical conductivity and carrier concentration, but retains the film's high-visible transparency.

  10. First-principles study on the elastic properties of B′ and Q phase in Al-Mg-Si (-Cu) alloys

    First-principles calculations within the density functional theory have been carried out to study the structural, elastic and electronic properties of B′ and Q phases in Al-Mg-Si (-Cu) alloys. The obtained lattice constant a is reduced while c is increased with the addition of Cu into B′ phase Al3Mg9Si7. The lower formation enthalpy of Q phase Al3Cu2Mg9Si7 shows that the structural stability is improved after the addition of Cu into the B′ phase. The calculated elastic constants Cij with the exception of C13 for Q phase are larger than for B′ phase. In addition, the derived bulk, shear, Young's modulus and Debye temperature except Poisson's ratio are also significantly increased with Cu addition, indicating that Q phase has a favorable improvement of hardness. The elastic anisotropies of the two phases are discussed in detail using several criteria, showing that the anisotropy degree of B′ phase is larger than of Q phase. The electronic structures show that the two phases possess a mixed bonding character of covalent and ionic, and Cu-Si bonding is beneficial in stabilizing the Q phase due to the hybridization of Cu 3d and Si 3p orbits.

  11. Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.

    Igor Landais

    2015-05-01

    Full Text Available Human Cytomegalovirus (HCMV encodes multiple microRNAs (miRNAs whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR innate immunity pathway as a possible target of HCMV miRNAs. Luciferase reporter assay screens further identified TLR2 as a target of HCMV miR-UL112-3p. TLR2 plays a major role in innate immune response by detecting both bacterial and viral ligands, including HCMV envelope proteins gB and gH. TLR2 activates a variety of signal transduction routes including the NFκB pathway. Furthermore, TLR2 plays an important role in controlling CMV infection both in humans and in mice. Immunoblot analysis of cells transfected with a miR-UL112-3p mimic revealed that endogenous TLR2 is down-regulated by miR-UL112-3p with similar efficiency as a TLR2-targeting siRNA (siTLR2. We next found that TLR2 protein level decreases at late times during HCMV infection and correlates with miR-UL112-3p accumulation in fibroblasts and monocytic THP1 cells. Confirming direct miR-UL112-3p targeting, down-regulation of endogenous TLR2 was not observed in cells infected with HCMV mutants deficient in miR-UL112-3p expression, but transfection of miR-UL112-3p in these cells restored TLR2 down-regulation. Using a NFκB reporter cell line, we found that miR-UL112-3p transfection significantly inhibited NFκB-dependent luciferase activity with similar efficiency as siTLR2. Consistent with this observation, miR-UL112-3p transfection significantly reduced the expression of multiple cytokines (IL-1β, IL-6 and IL-8 upon stimulation with a TLR2 agonist. Finally, miR-UL112-3p transfection significantly inhibited the TLR2-induced post-translational activation of IRAK1, a kinase located in the upstream section of the TLR2/NFκB signaling axis. To our knowledge, this is the first identified mechanism of TLR2 modulation by HCMV and is the first report of functional targeting of TLR2 by a viral miRNA. These

  12. Synthesis, crystal structures and optical properties of two congruent-melting isotypic diphosphates: LiM3P2O7 (M=Na, K)

    Two new isotypic diphosphates, LiNa3P2O7 (1) and LiK3P2O7 (2), have been synthesized by conventional solid-state reaction. The single-crystal X-ray structural analyses have shown that they crystallize in the orthorhombic space group C2221 (No. 20) with the unit cells: a=5.4966(2) Å, b=9.1365(4) Å, c=12.2764(5) Å for compound 1 and a=6.0373(14) Å, b=9.339(2) Å, c=13.292(3) Å for compound 2. The LiM3P2O7 (M=Na, K) consist of two-dimensional [LiP2O7]3− layers, which are composed by LiO4 tetrahedral and diphosphate groups, the Na or K atoms are filled in the interlayers and balance the charge. Second harmonic generation (SHG) on powder samples have been measured using Kurtz and Perry techniques. Thermal analyses, IR spectroscopy, UV–vis–NIR diffuse reflectance spectra, and band structure calculations are performed on the reported compounds. - Graphical Abstract: LiM3P2O7 (M=Na, K) consists of a two-dimensional infinite [LiP2O7]3− layer, which is composed by LiO4 tetrahedra and diphosphate groups. Highlights: ► LiNa3P2O7 and LiK3P2O7 are new compounds in the Li2O–M2O (M=Na, K)–P2O5 systems. ► Crystal structures of LiNa3P2O7 and LiK3P2O7 consist of two-dimensional [LiP2O7]3− layers. ► LiNa3P2O7 and LiK3P2O7 are congruent melting compounds.

  13. Ultrafine-Grain and Isotropic Cu/SAC305/Cu Solder Interconnects Fabricated by High-Intensity Ultrasound-Assisted Solidification

    Ji, Hongjun; Wang, Qiang; Li, Mingyu; Wang, Chunqing

    2014-07-01

    With the miniaturization of portable electronic devices, the size of solder joint interconnects is decreasing to micrometer levels. These joints possess only several or even one or two grains, resulting in anisotropy and failure issues. Direct ultrasound-assisted solidification of Cu/SAC305/Cu interconnects for grain refinement and fabrication of isotropic solder joints is presented herein. These joints consist of many β-Sn grains. The average cross-sectional area of the Sn-rich phase is significantly reduced by up to 99% when compared with conventional as-reflowed samples. The ultrasonic power density exhibits a threshold value for affecting the microstructures. Below 200 W cm-2, the β-Sn grains were refined and had circular shape. The Ag3Sn phase grew in a manner similar to branched coral to sizes reaching 30 μm, or as rods aggregated together with Cu6Sn5 tube fragments. Above 200 W cm-2, the microstructures were coarsened and Ag3Sn had plate-like shape. The thickness of Cu6Sn5 intermetallic layers at the Cu/solder interfaces was reduced by more than 26%. The relationships among the ultrasonic power, nucleation rate, local temperature drop, and pressure were identified. At the highest power density of 267 W cm-2, the nucleation rate was about 4.05 × 1014 m-3 s-1, the local temperature drop was 248 K, and the local pressure was on the order of several GPa.

  14. Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.

    Joseph W Jackson

    Full Text Available Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and contain several pro-inflammatory molecules including cytokines and chemokines that mediate leukocyte recruitment and activation. Not surprisingly, platelet dysfunction is known to contribute to several inflammatory disorders. Antiplatelet therapies, such as aspirin, adenosine diphosphate (ADP antagonists, glycoprotein IIb/IIIa (GPIIb/IIIa inhibitors, and anticoagulants such as warfarin, dampen platelet activity at the risk of unwarranted bleeding. Thus, the development of drugs that reduce platelet-mediated inflammation without interfering with thrombus formation is of importance to combat platelet-associated disorders. We have shown here for the first time that the tetracycline antibiotic, minocycline, administered to HIV-infected individuals reduces plasma levels of soluble CD40L and platelet factor 4 levels, host molecules predominately released by platelets. Minocycline reduced the activation of isolated platelets in the presence of the potent platelet activator, thrombin, as measured by ELISA and flow cytometry. Platelet degranulation was reduced upon exposure to minocycline as shown by mepacrine retention and flow cytometry. However, minocycline had no effect on spreading, aggregation, GPIIb/IIIa activation, or in vivo thrombus formation. Lastly, immunoblot analysis suggests that the antiplatelet activity of minocycline is likely mediated by inhibition of mixed lineage kinase 3 (MLK3-p38 MAPK signaling axis and loss of p38 activity. Our findings provide a better understanding of platelet biology and a novel repurposing of an established antibiotic, minocycline, to specifically reduce platelet granule release without affecting thrombosis, which may yield insights in generating novel, specific antiplatelet therapies.

  15. Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis

    Jackson, Joseph W.; Singh, Meera V.; Singh, Vir B.; Jones, Letitia D.; Davidson, Gregory A.; Ture, Sara; Morrell, Craig N.; Schifitto, Giovanni; Maggirwar, Sanjay B.

    2016-01-01

    Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and contain several pro-inflammatory molecules including cytokines and chemokines that mediate leukocyte recruitment and activation. Not surprisingly, platelet dysfunction is known to contribute to several inflammatory disorders. Antiplatelet therapies, such as aspirin, adenosine diphosphate (ADP) antagonists, glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors, and anticoagulants such as warfarin, dampen platelet activity at the risk of unwarranted bleeding. Thus, the development of drugs that reduce platelet-mediated inflammation without interfering with thrombus formation is of importance to combat platelet-associated disorders. We have shown here for the first time that the tetracycline antibiotic, minocycline, administered to HIV-infected individuals reduces plasma levels of soluble CD40L and platelet factor 4 levels, host molecules predominately released by platelets. Minocycline reduced the activation of isolated platelets in the presence of the potent platelet activator, thrombin, as measured by ELISA and flow cytometry. Platelet degranulation was reduced upon exposure to minocycline as shown by mepacrine retention and flow cytometry. However, minocycline had no effect on spreading, aggregation, GPIIb/IIIa activation, or in vivo thrombus formation. Lastly, immunoblot analysis suggests that the antiplatelet activity of minocycline is likely mediated by inhibition of mixed lineage kinase 3 (MLK3)-p38 MAPK signaling axis and loss of p38 activity. Our findings provide a better understanding of platelet biology and a novel repurposing of an established antibiotic, minocycline, to specifically reduce platelet granule release without affecting thrombosis, which may yield insights in generating novel, specific antiplatelet therapies. PMID:27270236

  16. Valence Band Character of NiS2-xSex using 3p-3d Resonant ARPES

    Han, Garam; Kim, Yeongkwan; Koh, Yoonyoung; Kim, Beomyoung; Song, Dongjoon; Seo, Jungjin; Kyung, Wonshik; Lee, Kyungdong; Kim, Changyoung

    2013-03-01

    Understanding the strong correlated system is one of the most challenging tasks in condensed matter physics. Especially, the metal insulator transition (MIT) has been one of the major topics recent few decades. NiS2-xSex is known as one of famous material which has MIT. The cubic pyrite NiS2 is a charge-transfer (CT) insulator. NiS2 attracts particular interest as it easily forms a solid solution with NiSe2 (NiS2-xSex) which, while being isoelectronic and isostructural to NiS2, is nevertheless a good metal. MIT, induced by Se alloying, is observed at low temperature (T) for x =0.45. Perucchi and his collaborators revealed closed relation between MIT and band width through comparison of infrared spectroscopy result and LDA calculation. However, it was only an indirect observation, and is inconsistent with recent proposal that NiS2 is not a CT insulator but an insulator due to the bonding-antibonding splitting in the S - S (Se - Se) dimers. To reveal the true mechanism in the MIT in NiS2-xSex, resonant photoemission experiment is essential. According to competing theories (CT insulator and insulator due to bonding-antibonding splitting), it is expected that the character of the main band that is responsible for the MIT should be different. Therefore, we performed 3p->3d resonant ARPES for various Se dopings (x =0.43; insulator, x =0.5, 0.7, 2.0; metal) and observed a significant change between on- and off-resonances near the MIT. Our experimental result supports that the origin of MIT in NiS2-xSex is the CT theory rather than the dimer theory.

  17. Effect of P5+ on spectroscopy and structure of Yb3+/Al3+/P5+ co-doped silica glass

    Two series of silica glasses [(95.9−x)SiO2–4Al2O3–xP2O5–0.1Yb2O3 (in mol%, x=0–10) and (92−y) SiO2–4Al2O3–4P2O5–yYb2O3 (in mol%, y=0–0.2)] were prepared by sol–gel method combined with high-temperature sintering. The relationship between the glass structure and spectroscopic properties is investigated. Significant alterations in density, refractive index, absorption and emission cross sections, fluorescence lifetime, and scalar crystal field NJ are observed at a molar ratio of P5+/Al3+=1 due to the transformation of P5+ structure type from AlPO4-like to PO4 units. This structural change is clearly observed in Raman spectra. In addition, NMR experimental results suggest that Yb3+ is mainly located in AlPO4-like but not SiO4 units at a molar ratio of P5+/Al3+=1, and also Raman spectra reveals the presence of P=O linkage in samples with molar ratio of P5+/Al3+>1. This further demonstrates that it is due to the formation of P=O site but not the simple addition of P2O5 in Yb3+/Al3+/P5+ co-doped silica glass to significantly decrease the absorption and emission cross sections of Yb3+. It reflects in the change of Yb3+ Stark splitting, and is revealed by the decline of Yb3+ asymmetry degree. - Highlights: • Silica glasses doped with P5+, Yb3+, Al3+ were successfully prepared. • Their optical and spectroscopic properties were measured at room temperature. • Structure–property relationships of these glasses were investigated

  18. Synthesis of ethanol via syngas on Cu/SiO2 catalysts with balanced Cu0-Cu+ sites.

    Gong, Jinlong; Yue, Hairong; Zhao, Yujun; Zhao, Shuo; Zhao, Li; Lv, Jing; Wang, Shengping; Ma, Xinbin

    2012-08-29

    This paper describes an emerging synthetic route for the production of ethanol (with a yield of ~83%) via syngas using Cu/SiO(2) catalysts. The remarkable stability and efficiency of the catalysts are ascribed to the unique lamellar structure and the cooperative effect between surface Cu(0) and Cu(+) obtained by an ammonia evaporation hydrothermal method. Characterization results indicated that the Cu(0) and Cu(+) were formed during the reduction process, originating from well-dispersed CuO and copper phyllosilicate, respectively. A correlation between the catalytic activity and the Cu(0) and Cu(+) site densities suggested that Cu(0) could be the sole active site and primarily responsible for the activity of the catalyst. Moreover, we have shown that the selectivity for ethanol or ethylene glycol can be tuned simply by regulating the reaction temperature. PMID:22625653

  19. Interfacial tension studies between Fe-Cu-Ni sulfide and halo-norilsk basalt slag system

    SU; Shangguo

    2005-01-01

    The interfacial tension of the matte/halo-Norilsk basalt slag systems of FeS-Cu2S-Ni3S2 and FeO-FeS were investigated using the sessile drop technique. The results indicate that interfacial tension decreases with increasing copper and nickel contents in the matte of FeS-Cu2S-Ni3S2 system while it increases with increasing oxygen content in the matte of FeO-FeS system. It is inferred from these results that two conditions are critical for the formation of giant Cu-Ni sulfide deposits. One is that mafic-ultramafic parent magma of sulfide deposits should be rich in copper and nickel where due to the low interfacial tension, it is difficult to form sulfide droplet in the early stage of magma evolution. In other words, sulfide liquid conglomeration occurs more difficultly. The other condition is that the magma emplacement should be shallow; and a lot of faults occur in the magma emplacement field. Since oxygen content is high in the environment, interfacial tension is high, which helps sulfide liquid conglomeration and consequently Cu-Ni sulfide deposits form.

  20. Fe3S4 and Fe3O4 magnetic nanocrystals: magneto-optical and Mössbauer spectroscopy study

    Lin, C.-R.; Tseng, Y.-T.; Ovchinnikov, S. G.; Ivantsov, R. D.; Edelman, I. S.; Fedorov, A. S.; Kuzubov, A. A.; Fedorov, D. A.; Starchikov, S. S.; Lyubutin, I. S.

    2014-04-01

    Iron oxide magnetite (Fe3O4) should be a reasonable analog for conception and understanding of the magnetic properties of iron sulfide greigite (Fe3S4)—one of the most required magnetic materials having numerous applications but being far from the complete understanding now. We present here a comparative study of the Mössbauer effect (ME) and the magnetic circular dichroism (MCD) spectroscopy of Fe3O4 and Fe3S4 nanoparticles. The ME spectrum parameters of Fe3S4 are shown to distinguish strongly from that of Fe3O4, and the MCD spectrum shapes are shown to be absolutely different for two compounds. To clarify the origin of the Fe3S4 MCD spectrum we have performed ab initio band structure calculations and identified the MCD spectrum features with the transitions between calculated energy states.

  1. Defect characterization of Ga$_4$Se$_3$S layered single crystals by thermoluminescence

    Isik M; Delice S; Gasanly N

    2016-04-01

    Trapping centres in undoped Ga$_4$Se$_3$S single crystals grown by Bridgman method were characterized for the first time by thermoluminescence (TL) measurements carried out in the low temperature range of 15−300 K. After illuminating the sample with blue light (∼470 nm) at 15 K, TL glow curve exhibited one peak around 74 K when measured with a heating rate of 0.4 K/s.The results of the various analysis methods were in good agreement about the presence of one trapping centre with an activation energy of 27 meV. Analysis of curve fitting method indicated that mixed order of kinetics dominates the trapping process. Heating rate dependence and distribution of the traps associated with the observed TL peak were also studied. The shift of peak maximum temperature from 74 to 113 K with increasing rate from 0.4 to 1.2 K/s was revealed. Distribution of traps was investigated using an experimental technique based on cleaning the centres giving emission at lower temperatures. Activation energies of the levels were observed to be increasing from 27 to 40 meV by rising the stopping temperature from 15 to 36 K.

  2. [Application of 3S techniques in ecological landscape planning of Harbin suburb].

    Fan, Wenyi; Gong, Wenfeng; Liu, Dandan; Zhou, Hongze; Zhu, Ning

    2005-12-01

    With the image data (SPOT), soil utilization map (1:50000) and other related materials of Harbin, and under the support of GIS, RS and GPS techniques, this paper obtained the landscape pattern of Harbin suburb and the Digital Elevation Model (DEM) of Harbin. Indices including mean patch area, landscape dominance, mean slope, mean altitude, and fragmentation degree were selected and synthetically analyzed, with the ecological landscape planning made by DEM model. The results showed that 3S techniques could help to decide typical landscape types. The landscape type database was established, and the landscape type thematic map was generated, with land use status and landscape distribution, physiognomy, and land use types combined. The ecological landscape planning was described in large scale with the image data and DEM combined, and the landscape structure of Harbin suburb was reflected directly with the ecological landscape planning and DEM combined, which improved the ecological function in this region, and provided scientific bases to the healthy development in urban-rural integration area. PMID:16515174

  3. Radiative Bottomonium Spectroscopy at the Y(2, 3S) Resonances at BaBar

    Lewis, Peter M. [Stanford Univ., CA (United States)

    2013-08-01

    The compact bound state consisting of a bottom and anti-bottom quark pair interacting via the strong nuclear force is called “bottomonium.” A wealth of long-lived bottomonium states can be both experimentally produced and theoretically described, providing a unique tool to probe calculation techniques with experiment. Bottomonia with total angular momentum J = 1 and orbital angular momentum L = 0 at a variety of radial excitations n – called Υ(nS) – can be produced at electron-positron colliders. The BABAR experiment, located at the interaction point of such a collider (the PEP-II storage ring), has observed 122 million Υ(3S) and 100 million Υ(2S) decays. Some of these involve a transition to the bottomonium state χbJ (nP) (L = 1 and J = (0, 1, 2)), emitting a photon, with subsequent transition to a lower Υ(nS), also emitting a photon. The final Υ(nS) can be identified through a decay to two muons. The dependence of the branching fractions and photon energies in this process on the spin state of the intermediate χbJ (nP) is a key test of phenomenological models. To this end, this dissertation contains a nearly comprehensive study of these transitions with an emphasis on experimentally optimal discrimination between various models. This focus spurs innovative techniques that complement a large array of physics results, both presented in detail herein.

  4. Thermochemistry of the Cu{sub 2}Se–In{sub 2}Se{sub 3} system

    Ider, M., E-mail: muhsin.ider@usak.edu.tr [Department of Chemical Engineering, Usak University, 64200 Usak (Turkey); Pankajavalli, R. [Thermodynamics and Kinetics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Zhuang, W. [General Research Institute for Nonferrous Metals, Grirem Advanced Materials Co., Ltd., Beijing 100088 (China); Shen, J.Y. [General Research Institute for Nonferrous Metals, Beijing 100088 (China); Anderson, T.J. [Department of Chemical Engineering, University of Florida, Gainesville, FL 32611 (United States)

    2014-08-01

    Highlights: • Solid state EMF experiments were employed to obtain Gibbs energy data of CuInSe{sub 2}. • The phase diagram data in the Cu{sub 2}Se–In{sub 2}Se{sub 3} pseudo-binary system were assessed. • ΔG{sub f}{sup ∘} CuInSe{sub 2} (α) ± 0.0003 = 0.0051T (K) − 220.92 kJ/mol (949–1044 K) was obtained. • ΔG{sub f}{sup ∘} CuInSe{sub 2} (δ) ± 0.0004 = −0.0043T (K) − 210.92 kJ/mol (1055–1150 K) was obtained. • T{sub trans} and, ΔH{sub trans}{sup ∘} for α to δ-CuInSe{sub 2} were determined to be 1064 K and 10.0 kJ/mol. - Abstract: Solid state electrochemical cells were employed to obtain standard Gibbs energy of formation of CuInSe{sub 2} as well as the temperature and enthalpy of the α to δ-CuInSe{sub 2} transformation in the Cu{sub 2}Se–In{sub 2}Se{sub 3} pseudo-binary system. The reversible EMF data of the following solid-state electrochemical cell were measured: Pt,In(l),In{sub 2}O{sub 3}(s)‖YSZ‖In{sub 2}O{sub 3}(s),Cu{sub 2}Se(s),Cu(s),CuInSe{sub 2}(αorδ),C,PtCell I The calculated standard molar Gibbs energy of formation of α and δ-CuInSe{sub 2} from measured data are given by ΔG{sub f}{sup ∘}CuInSe{sub 2}(α)±0.0003=0.0051T(K)-220.92kJ/mol(949–1044K) ΔG{sub f}{sup ∘}CuInSe{sub 2}(δ)±0.0004=-0.0043T(K)-210.92kJ/mol(1055–1150K) The α to δ phase transition temperature T{sub trans} and the enthalpy of transition ΔH{sub trans}{sup ∘} for CuInSe{sub 2} were determined to be 1064 K and 10.0 kJ/mol respectively. ΔS{sub trans}{sup ∘} was calculated as 9.4 J/mol K. The thermodynamic and phase diagram data in the Cu{sub 2}Se–In{sub 2}Se{sub 3} pseudo-binary system were critically assessed. A self consistent set of thermochemistry and phase diagram data was obtained with the help of measured data. The liquid phase along the Cu{sub 2}Se–In{sub 2}Se{sub 3} pseudo-binary was calculated with the Redlich–Kister model. The β-Cu{sub 1}In{sub 3}Se{sub 5} and γ-Cu{sub 1}In{sub 5}Se{sub 8} phases were

  5. Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration.

    Han, Bo; Lian, Ling; Li, Xin; Zhao, Chunfang; Qu, Lujiang; Liu, Changjun; Song, Jiuzhou; Yang, Ning

    2016-01-01

    Marek's disease (MD) is a highly contagious viral neoplastic disease caused by Marek's disease virus (MDV), which can lead to huge economic losses in the poultry industry. Recently, microRNAs (miRNAs) have been found in various cancers and tumors. In recent years, 994 mature miRNAs have been identified through deep sequencing in chickens, but only a few miRNAs have been investigated further in terms of their function. Previously, gga-miR-103-3p was found downregulated in MDV-infected samples by using Solexa deep sequencing. In this study, we further verified the expression of gga-miR-103-3p among MDV-infected spleen, MD lymphoma from liver, noninfected spleen, and noninfected liver, by qPCR. The results showed that the expression of gga-miR-103-3p was decreased in MDV-infected tissues, which was consistent with our previous study. Furthermore, two target genes of gga-miR-103-3p, cyclin E1 (CCNE1) and transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2), were predicted and validated by luciferase reporter assay, qPCR, and western blot analysis. The results suggested that CCNE1 and TFDP2 are direct targets of gga-miR-103-3p in chickens. Subsequent cell proliferation and migration assay showed that gga-miR-103-3p suppressed MDCC-MSB1 migration, but did not obviously modulate MDCC-MSB1 cell proliferation. In conclusion, gga-miR-103-3p targets the CCNE1 and TFDP2 genes, and suppresses cell migration, which indicates that it might play an important role in MD tumor transformation. PMID:26935418

  6. Blockage of miR-92a-3p with locked nucleic acid induces apoptosis and prevents cell proliferation in human acute megakaryoblastic leukemia.

    Sharifi, M; Salehi, R

    2016-01-01

    MicroRNAs (miRNAs) are non-coding RNAs involved in post-transcriptional regulation of gene expression. In many cancers, up- or downregulation of different miRNAs is reported. In acute myeloid leukemia, upregulation of miR-92a-3p was reported in human in vitro studies. We performed blockage of miR-29a-3p in human acute megakaryoblastic leukemia cell line (M-07e) by using locked nucleic acid (LNA) and cell proliferation; apoptosis and necrosis were assessed. At different time points after LNA-anti-miR92a-3p transfection, miR-92a-3p quantitation was assessed by qRT-real-time PCR, MTT assay and annexin/propidium iodide staining were performed. The data were processed using the ANOVA test. At all three time points, the expression of miR-92a-3p was lower in the LNA-anti-miR group compared with the control groups. Cell viability between LNA-Anti-miR and the control group was statistically significant. Blockage of miR-92a-3p was associated with increment of the ratio of apoptotic cells in the LNA-anti-miR group was higher than the other group. The ratio of necrotic cells in the LNA-antimiR group was higher than the other groups. These assessments indicate that miR-92a-3p blockage can decrease the viability of M-07e cells, which is mainly due to induction of apoptosis and necrosis. Our findings could open up a path to a miRNA based therapeutic approach for treatment of acute megakaryoblastic leukemia. PMID:26658357

  7. MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.

    Dai, Xin; Chen, Xi; Chen, Qun; Shi, Lei; Liang, Hongwei; Zhou, Zhen; Liu, Qian; Pang, Wenjing; Hou, Dongxia; Wang, Cheng; Zen, Ke; Yuan, Yaozong; Zhang, Chen-Yu; Xia, Lu

    2015-06-26

    Intestinal inflammation is characterized by epithelial disruption, leading to the loss of barrier function, recruitment of immune cells, and host immune responses to gut microbiota. PepT1, a di/tripeptide transporter that uptakes bacterial products, is up-regulated in inflamed colon tissue, which implies its role in bacterium-associated intestinal inflammation. Although microRNA (miRNA)-mediated gene regulation has been found to be involved in various processes of inflammatory bowel disease (IBD), the biological function of miRNAs in the pathogenesis of IBD remains to be explored. In this study we detected miRNA expression patterns in colon tissues during colitis and investigated the mechanism underlying the regulation of colonic PepT1 by miRNAs. We observed an inverse correlation between PepT1 and miR-193a-3p in inflamed colon tissues with active ulcerative colitis, and we further demonstrated that miR-193a-3p reduced PepT1 expression and activity as a target gene and subsequently suppressed the NF-κB pathway. Intracolonic delivery of miR-193a-3p significantly ameliorated dextran sodium sulfate-induced colitis, whereas the overexpression of colonic PepT1 via PepT1 3'-untranslated region mutant lentivirus vector abolished the anti-inflammatory effect of miR-193a-3p. Furthermore, antibiotic treatment eliminated the difference in the dextran sodium sulfate-induced inflammation between the presence and absence of miR-193a-3p. These findings suggest that miR-193a-3p regulation of PepT1 mediates the uptake of bacterial products and is a potent mechanism during the colonic inflammation process. Overall, we believe miR-193a-3p may be a potent regulator of colonic PepT1 for maintaining intestinal homeostasis. PMID:25931122

  8. Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine

    Oliver Ries; Martin Büschleb; Markus Granitzka; Dietmar Stalke; Christian Ducho

    2014-01-01

    (2S,3S)-3-Hydroxyleucine can be found in an increasing number of bioactive natural products. Within the context of our work regarding the total synthesis of muraymycin nucleoside antibiotics, we have developed a synthetic approach towards (2S,3S)-3-hydroxyleucine building blocks. Application of different protecting group patterns led to building blocks suitable for C- or N-terminal derivatization as well as for solid-phase peptide synthesis. With respect to according motifs occurring in natur...

  9. Toxicity of CuO nanoparticles and Cu ions on Tubifex tubifex

    Rosca, Mette; Wolter, Preben; Obiribea, Millicent; Triantafillopoulos, Katerina

    2015-01-01

    Abstract The amount of Copper (Cu) in aquatic environments is rising along with the increasing usage of Cu in industries and agriculture. Additionally nanoparticles (NPs) such as Copper(II) oxide nanoparticles (CuO NPs) (>100 nm) are being increasingly produced and led into the environment. Cu is an essential micronutrient necessary for most animals’ and plants’ survival, but an excess amount of Cu can be toxic. Cu that is led into the aquatic environments is expected to settle in the sedi...

  10. Thermodynamic evaluation of Cu-H-O-S-P system - Phase stabilities and solubilities for OFP-copper

    A thermodynamic evaluation for Cu-H-O-S-P has been made, with special focus on the phase stabilities and solubilities for OFP-copper. All binary systems including copper have been reviewed. Gaseous species and stoichiometric crystalline phases have been included for higher systems. Sulphur in OFP-copper will be found in sulphides. The sulphide can take different morphologies but constant stoichiometry Cu2S. The solubility of sulphur in FCC-copper reaches ppm levels already at 550 deg C and decreases with lower temperature. No phosphorus-sulphide will be stable, although the copper sulphide can be replaced by copper sulphates at high partial pressure oxygen like in the oxide scale. Phosphorus has a high affinity to oxygen, and phosphorus oxide P4O10 and copper phosphates (Cu2P2O7 and Cu3(PO4)2) are all more stable than copper oxide Cu2O. With hydrogen present at atmospheric pressure, copper phosphates Cu2P2O7 and Cu3(P2O6OH)2 are both more stable than water vapour or aqueous water at temperatures below 400 deg C. At high pressure conditions, the copper phosphates can be reduced giving water. However, the phosphates are still more stable than water vapour. The solubility limit of phosphorus in FCC-copper at 25 deg C is 510 ppm, in equilibrium with copper phosphide Cu3P. The major part of phosphorus in OFP-copper will be in solid solution. Oxygen in FCC-copper has a very low solubility. In the presence of a strong oxide forming element such as phosphorus in OFP-copper, the solubility decreases even more. Copper oxides will become stable first when all phosphorus has been consumed, which takes place at twice the phosphorus content, calculated in weight. Hydrogen has a low solubility in copper, calculated as 0.1 ppm at 675 deg C. No crystalline hydrogen phase has been found stable at atmospheric pressures and above 400 deg C. At lower temperatures the hydrogen containing phosphate Cu3(P2O6OH)2 can become stable. Measured hydrogen contents for OFP-copper are higher than

  11. Thermodynamic evaluation of Cu-H-O-S-P system - Phase stabilities and solubilities for OFP-copper

    Magnusson, Hans; Frisk, Karin [Swerea KIMAB, Kista (Sweden)

    2013-04-15

    A thermodynamic evaluation for Cu-H-O-S-P has been made, with special focus on the phase stabilities and solubilities for OFP-copper. All binary systems including copper have been reviewed. Gaseous species and stoichiometric crystalline phases have been included for higher systems. Sulphur in OFP-copper will be found in sulphides. The sulphide can take different morphologies but constant stoichiometry Cu{sub 2}S. The solubility of sulphur in FCC-copper reaches ppm levels already at 550 deg C and decreases with lower temperature. No phosphorus-sulphide will be stable, although the copper sulphide can be replaced by copper sulphates at high partial pressure oxygen like in the oxide scale. Phosphorus has a high affinity to oxygen, and phosphorus oxide P{sub 4}O{sub 10} and copper phosphates (Cu{sub 2}P{sub 2}O{sub 7} and Cu{sub 3}(PO{sub 4}){sub 2}) are all more stable than copper oxide Cu{sub 2}O. With hydrogen present at atmospheric pressure, copper phosphates Cu{sub 2}P{sub 2}O{sub 7} and Cu{sub 3}(P{sub 2}O{sub 6}OH){sub 2} are both more stable than water vapour or aqueous water at temperatures below 400 deg C. At high pressure conditions, the copper phosphates can be reduced giving water. However, the phosphates are still more stable than water vapour. The solubility limit of phosphorus in FCC-copper at 25 deg C is 510 ppm, in equilibrium with copper phosphide Cu{sub 3}P. The major part of phosphorus in OFP-copper will be in solid solution. Oxygen in FCC-copper has a very low solubility. In the presence of a strong oxide forming element such as phosphorus in OFP-copper, the solubility decreases even more. Copper oxides will become stable first when all phosphorus has been consumed, which takes place at twice the phosphorus content, calculated in weight. Hydrogen has a low solubility in copper, calculated as 0.1 ppm at 675 deg C. No crystalline hydrogen phase has been found stable at atmospheric pressures and above 400 deg C. At lower temperatures the hydrogen

  12. MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2

    Fujii, Tomomi; Shimada, Keiji; Asano, Aya; Tatsumi, Yoshihiro; Yamaguchi, Naoko; Yamazaki, Masaharu; Konishi, Noboru

    2016-01-01

    Aberrant expression of microRNAs (miRNAs) is involved in the development and progression of various types of cancers. In this study, we investigated the role of miR-331-3p in cell proliferation and the expression of keratinocyte differentiation markers of uterine cervical cancer cells. Moreover, we evaluated whether neuropilin 2 (NRP2) are putative target molecules that regulate the human papillomavirus (HPV) related oncoproteins E6 and E7. Cell proliferation in the human cervical cancer cell lines SKG-II, HCS-2, and HeLa was assessed using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay. Cellular apoptosis was measured using the TdT-mediated dUTP nick end labeling (TUNEL) and Annexin V assays. Quantitative RT-PCR was used to measure the messenger RNA (mRNA) expression of the NRP2, E6, E7, p63, and involucrin (IVL) genes. A functional assay for cell growth was performed using cell cycle analyses. Overexpression of miR-331-3p inhibited cell proliferation, and induced G2/M phase arrest and apoptosis in SKG-II, HCS-2 and HeLa cells. The luciferase reporter assay of the NRP2 3′-untranslated region revealed the direct regulation of NRP2 by miR-331-3p. Gene expression analyses using quantitative RT-PCR in SKG-II, HCS-2, and HeLa cells overexpressing miR-331-3p or suppressing NRP2 revealed down-regulation of E6, E7, and p63 mRNA and up-regulation of IVL mRNA. Moreover, miR-331-3p overexpression was suppressed NRP2 expression in protein level. We showed that miR-331-3p and NRP2 were key effectors of cell proliferation by regulating the cell cycle, apoptosis. NRP-2 also regulates the expression of E6/E7 and keratinocyte differentiation markers. Our findings suggest that miR-331-3p has an important role in regulating cervical cancer cell proliferation, and that miR-331-3p may contribute to keratinocyte differentiation through NRP2 suppression. miR-331-3p and NRP2 may contribute to anti-cancer effects

  13. Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion

    Lopez, Jesus Adrian [Laboratorio de Terapia Genica, Departamento de Genetica y Biologia Molecular, CINVESTAV, Av. IPN 2508, Mexico 07360 D.F. (Mexico); Alvarez-Salas, Luis Marat, E-mail: lalvarez@cinvestav.mx [Laboratorio de Terapia Genica, Departamento de Genetica y Biologia Molecular, CINVESTAV, Av. IPN 2508, Mexico 07360 D.F. (Mexico)

    2011-06-10

    Highlights: {yields} In this study we examine miR-34c-3p and miR-34c-5p functions in SiHa cells. {yields} We study miRNA effect on cell proliferation, anchorage independent growth, apoptosis, cell motility and invasion. {yields} We find that miR-34c-3p and miR-34c-5p inhibition of proliferation and anchorage independent growth are exclusive to SiHa cells. {yields} miR-34c-3p induces apoptosis and inhibits cell motility and invasion in SiHa cells. {yields} In this study we conclude that miR-34c-3p functions as a tumor suppressor differ from miR-34c-5p. -- Abstract: MicroRNAs (miRNA) regulate expression of several genes associated with human cancer. Here, we analyzed the function of miR-34c, an effector of p53, in cervical carcinoma cells. Expression of either miR-34c-3p or miR-34c-5p mimics caused inhibition of cell proliferation in the HPV-containing SiHa cells but not in other cervical cells irrespective of tumorigenicity and HPV content. These results suggest that SiHa cells may lack of regulatory mechanisms for miR-34c. Monolayer proliferation results showed that miR-34c-3p produced a more pronounced inhibitory effect although both miRNAs caused inhibition of anchorage independent growth at similar extent. However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. A significant inhibition was observed only for miR-34c-3p on SiHa cells migration and invasion, therefore implying alternative regulatory pathways and targets. These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology.

  14. Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion

    Highlights: → In this study we examine miR-34c-3p and miR-34c-5p functions in SiHa cells. → We study miRNA effect on cell proliferation, anchorage independent growth, apoptosis, cell motility and invasion. → We find that miR-34c-3p and miR-34c-5p inhibition of proliferation and anchorage independent growth are exclusive to SiHa cells. → miR-34c-3p induces apoptosis and inhibits cell motility and invasion in SiHa cells. → In this study we conclude that miR-34c-3p functions as a tumor suppressor differ from miR-34c-5p. -- Abstract: MicroRNAs (miRNA) regulate expression of several genes associated with human cancer. Here, we analyzed the function of miR-34c, an effector of p53, in cervical carcinoma cells. Expression of either miR-34c-3p or miR-34c-5p mimics caused inhibition of cell proliferation in the HPV-containing SiHa cells but not in other cervical cells irrespective of tumorigenicity and HPV content. These results suggest that SiHa cells may lack of regulatory mechanisms for miR-34c. Monolayer proliferation results showed that miR-34c-3p produced a more pronounced inhibitory effect although both miRNAs caused inhibition of anchorage independent growth at similar extent. However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. A significant inhibition was observed only for miR-34c-3p on SiHa cells migration and invasion, therefore implying alternative regulatory pathways and targets. These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology.

  15. Downregulation of microRNA-362-3p and microRNA-329 promotes tumor progression in human breast cancer.

    Kang, H; Kim, C; Lee, H; Rho, J G; Seo, J-W; Nam, J-W; Song, W K; Nam, S W; Kim, W; Lee, E K

    2016-03-01

    p130Cas regulates cancer progression by driving tyrosine receptor kinase signaling. Tight regulation of p130Cas expression is necessary for survival, apoptosis, and maintenance of cell motility in various cell types. Several studies revealed that transcriptional and post-translational control of p130Cas are important for maintenance of its expression and activity. To explore novel regulatory mechanisms of p130Cas expression, we studied the effect of microRNAs (miRs) on p130Cas expression in human breast cancer MCF7 cells. Here, we provide experimental evidence that miR-362-3p and miR-329 perform a tumor-suppressive function and their expression is downregulated in human breast cancer. miR-362-3p and miR-329 inhibited cellular proliferation, migration, and invasion, thereby suppressing tumor growth, by downregulating p130Cas. Ectopic expression of p130Cas attenuated the inhibitory effects of the two miRs on tumor progression. Relative expression levels of miR-362-3p/329 and p130Cas between normal and breast cancer correlated inversely; miR-362-3p/329 expression was decreased, whereas that of p130Cas increased in breast cancers. Furthermore, we showed that downregulation of miR-362-3p and miR-329 was caused by differential DNA methylation of miR genes. Enhanced DNA methylation (according to methylation-specific PCR) was responsible for downregulation of miR-362-3p and miR-329 in breast cancer. Taken together, these findings point to a novel role for miR-362-3p and miR-329 as tumor suppressors; the miR-362-3p/miR-329-p130Cas axis seemingly has a crucial role in breast cancer progression. Thus, modulation of miR-362-3p/miR-329 may be a novel therapeutic strategy against breast cancer. PMID:26337669

  16. Phosphate enrichment mechanism in CaO-SiO2-FeO-Fe2O3-P2O5 steelmaking slags with lower binary basicity

    Li, Jin-yan; Zhang, Mei; Guo, Min; Yang, Xue-min

    2016-05-01

    The addition of silica to steelmaking slags to decrease the binary basicity can promote phosphate enrichment in quenched slag samples. In this study, we experimentally investigated phosphate enrichment behavior in CaO-SiO2-FeO-Fe2O3-P2O5 slags with a P2O5 content of 5.00% and the binary basicity B ranging from 1.0 to 2.0, where the (%Fe t O)/(%CaO) mass percentage ratio was maintained at 0.955. The experimental results are explained by the defined enrichment degree R_{C_2 S - C_3 P} of solid solution 2CaO·SiO2-3CaO·P2O5 (C2S-C3P), where R_{C_2 S - C_3 P} is a component of the developed ion and molecule coexistence theory (IMCT)- N i model for calculating the mass action concentrations N i of structural units in the slags on the basis of the IMCT. The asymmetrically inverse V-shaped relation between phosphate enrichment and binary basicity B was observed to be correlated in the slags under applied two-stage cooling conditions. The maximum content of P2O5 in the C2S-C3P solid solution reached approximately 30.0% when the binary basicity B was controlled at 1.3.

  17. MiRNA-199a-3p Regulates C2C12 Myoblast Differentiation through IGF-1/AKT/mTOR Signal Pathway

    Long Jia

    2013-12-01

    Full Text Available MicroRNAs constitute a class of ~22-nucleotide non-coding RNAs. They modulate gene expression by associating with the 3' untranslated regions (3' UTRs of messenger RNAs (mRNAs. Although multiple miRNAs are known to be regulated during myoblast differentiation, their individual roles in muscle development are still not fully understood. In this study, we showed that miR-199a-3p was highly expressed in skeletal muscle and was induced during C2C12 myoblasts differentiation. We also identified and confirmed several genes of the IGF-1/AKT/mTOR signal pathway, including IGF-1, mTOR, and RPS6KA6, as important cellular targets of miR-199a-3p in myoblasts. Overexpression of miR-199a-3p partially blocked C2C12 myoblast differentiation and the activation of AKT/mTOR signal pathway, while interference of miR-199a-3p by antisense oligonucleotides promoted C2C12 differentiation and myotube hypertrophy. Thus, our studies have established miR-199a-3p as a potential regulator of myogenesis through the suppression of IGF-1/AKT/mTOR signal pathway.

  18. Reactive scattering of carbon atoms: the reaction dynamics of C(3P, 1D) +C2H2 and C2H4

    The reaction dynamics of C(3P, 1D) with acetylene and ethylene have been investigated by using the crossed beam technique with mass spectrometric detection and time-of-flight (TOF) analysis. The novel capability of generating continuous supersonic beams of carbon atoms by a radio-frequency discharge beam source is exploited. From angular and velocity distribution measurements, the primary reaction products are identified, their relative importance assessed, and their dynamics of formation characterized. While the reaction C(3P) + C2H2(X1Σg+) has been found to lead to C3H + H and C3(X1Σg+) + H2(X1Σg+) in comparable amount, the reaction C(3P) + C2H4(X1At) has been found to lead, predominantly, to H + C3H3 (propargylene). The dynamics of the C(1D) reactions are also characterized. The spin-forbidden H2 elimination channel in the reaction C(3P) + C2H2 is attributed to the occurrence of inter-system-crossing between the triplet and singlet manifold of the C3H2 potential energy surfaces. Interestingly, these findings provide evidence that the C(3P) + C2H2 reaction maybe the source of both C3H and C3 species detected in the extreme environment of dense interstellar clouds and outflows of carbon stars, as well as in combustion systems. (author)

  19. Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.

    Krystyna Mazan-Mamczarz

    2014-01-01

    Full Text Available Deregulation of the translational machinery is emerging as a critical contributor to cancer development. The contribution of microRNAs in translational gene control has been established however; the role of microRNAs in disrupting the cap-dependent translation regulation complex has not been previously described. Here, we established that elevated miR-520c-3p represses global translation, cell proliferation and initiates premature senescence in HeLa and DLBCL cells. Moreover, we demonstrate that miR-520c-3p directly targets translation initiation factor, eIF4GII mRNA and negatively regulates eIF4GII protein synthesis. miR-520c-3p overexpression diminishes cells colony formation and reduces tumor growth in a human xenograft mouse model. Consequently, downregulation of eIF4GII by siRNA decreases translation, cell proliferation and ability to form colonies, as well as induces cellular senescence. In vitro and in vivo findings were further validated in patient samples; DLBCL primary cells demonstrated low miR-520c-3p levels with reciprocally up-regulated eIF4GII protein expression. Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity.

  20. Two aluminotriphosphates with closely related intersecting tunnel structures involving tetrahedral 'AlP' chains and layers: AAl3(P3O10)2, A=Rb, Cs

    Two new aluminotriphosphates, RbAl3(P3O10)2 and CsAl3(P3O10)2, were synthesized by solid-state reaction. They crystallize in non-centrosymmetric space groups: C2221 with a=9.8757(7)A, b=12.8854(10)A, c=11.9192(7)A (Z=4) for RbAl3(P3O10)2 and C2ce with a=10.0048(7)A, b=13.3008(10)A, c=12.1698(7)A (Z=4) for CsAl3(P3O10)2. Their 3D frameworks, built up of corner sharing P3O10 groups, AlO4 tetrahedra and AlO6 octahedra, exhibit several remarkable features. The AlO4 tetrahedra and P3O10 groups are directly associated through the corners, forming helical columns in the Rb-phase and 'helicoid' layers in the Cs-phase. The simultaneous presence of AlO4 and AlO6 species, rather rare in phosphates, leads to the formation of closely related [Al3P6O24]∞ layers in both structures, which differ by their stacking mode. The presence of intersecting tunnels running along and [001] directions, with Rb+ and Cs+ sitting at the intersections, shows the opened character of these two structures