3-kinase pathway controls: Topics by WorldWideScience.org

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor ?-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of ?-Catenin Signaling*

The expression status of the estrogen receptor alpha (ERα) and that of the epidermal growth factor receptor Her-2/neu frequently correlate inversely in breast cancers. While ERα-dependent...Full Text Available

2004-10-01

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Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110? but Not p110? Promotes Optimal Allergic Responses In Vivo1

The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered....Full Text Available

2010-03-19

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The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

The leukocyte-enriched p110γ and p110δ isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking...Full Text Available

2008-02-15

4

Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function.

SummaryThe Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes...Full Text Available

2009-07-15

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Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

Inhibition of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is an appealing method for decreasing the immunoresistance and augmenting T cell-mediated immunotherapy. A major impediment to this strategy is the impact of conventional PI3K/mTOR pathway inhibitors on T cell function. In particular, rapamycin, is a well-known immunosuppressant that can decrease the activity of the PI3K/mTOR pathway in tumor cells, but also has a profound inhibitory effect on T cells. Here we show that Honokiol, a natural dietary product isolated from an extract of seed cones from Magnolia grandiflora, can decrease PI3K/mTOR pathway-mediated immunoresistance of glioma, breast and prostate cancer cell lines, without affecting critical proinflammatory T cell functions. Specifically, we show that at doses sufficient to down-regulate levels of phospho-S6 ...

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The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors

OBJECTIVEPhosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions...Full Text Available

2010-04-01

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The hippo pathway in biological control and cancer development

SUMMARYTestosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain and behavior...Full Text Available

2010-04-29

8

British Library Electronic Table of Contents (United Kingdom)

Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with ...

2011-01-01

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Signal transduction pathway controlling synthesis of a class of degradative enzymes in Bacillus subtilis: expression of the regulatory genes and analysis of mutations in degS and degU.

How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry

The rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis are controlled by a signal transduction pathway defined by at least four regulatory genes:...Full Text Available

1990-02-01

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PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast

Immune challenge induces behavioral changes including reduced ingestion of palatable food. Multiple pathways likely contribute to this effect, including viscerosensory pathways controlling hypothalamic...Full Text Available

2008-11-01

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A Conserved Role for Phosphoinositide-3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy

Eukaryotic cells can massively transport their own cytoplasmic contents into a lytic compartment, the vacuole/lysosome, for recycling through a conserved system called autophagy. The key process in...Full Text Available

2011-01-01

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Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1α and increased fatty acid oxidative (FAO) capacity. It is...Full Text Available

2007-10-01

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Control of wrist position and muscle relaxation by shifting spatial frames of reference for motoneuronal recruitment: possible involvement of corticospinal pathways

BackgroundSerine proteinase inhibitors (Serpins) are a large superfamily of structurally related, but functionally diverse proteins that control essential proteolytic pathways in...Full Text Available

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Cell proliferation depends on mitochondrial Ca²⁺ uptake: inhibition by salicylate

It has previously been established that muscles become active in response to deviations from a threshold (referent) position of the body or its segments, and that intentional motor actions result from...Full Text Available

2010-05-01

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Analysis of control methods: mercury and cadmium pollution.

Store-operated Ca²⁺ entry (SOCE) is a ubiquitous Ca²⁺ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence...Full Text Available

2006-02-15

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A novel fluorescent pH probe for expression in plants

Physical system conceptual models are developed to illustrate the various interconnecting pathways of metal flow. Economic use of mercury and cadmium, as representative toxic heavy metals, is inventoried,...Full Text Available

1975-12-01

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Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae

BackgroundThe pH is an important parameter controlling many metabolic and signalling pathways in living cells. Recombinant fluorescent pH indicators (pHluorins) have come into vogue...Full Text Available

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Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine Kras^G12D-Induced Skin Carcinogenesis In Vivo

BackgroundWhen eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. Activated Gcn2p up-regulates the general amino...Full Text Available

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BosR (BB0647) Controls the RpoN-RpoS Regulatory Pathway and Virulence Expression in Borrelia burgdorferi by a Novel DNA-Binding Mechanism

BackgroundThe Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis....Full Text Available

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Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines, 07 Nov 2011 - 11 Nov 2011, Le Meridien New Delhi, New Delhi, India - SciDe

In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ...Full Text Available

2011-02-01

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Wastenet

... A better understanding of the links between nutrients, the gut microbiome and the intestinal immune system is likely to pave the way to the development of innovative approaches that target activation of specific immunological pathways for promoting the hostrsquo;s gut defense. Such knowledge should positively impact on the development of vaccine formulations and intervention strategies for improved control of enteric infections in developing countries. Registration fees # The Registration Fee is $715.00 on and before September 7, 2011. # After September 7, 2011, the ...

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Corrosion issues in the long term storage of aluminum-clad spent nuclear fuels

Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone

Approximately 8% of the spent nuclear fuel owned by the US Department of Energy is clad with aluminum alloys. The spent fuel must be either reprocessed or temporarily stored in wet or dry storage systems until a decision is made on final disposition in a repository. There are corrosion issues associated with the aluminum cladding regardless of the disposition pathway selected. This paper discusses those issues and provides data and analysis to demonstrate that control of corrosion induced degradation in aluminum clad spent fuels can be achieved through relatively simple engineering practices.

1996-03-24

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The Significance of PITX2 Overexpression in Human Colorectal Cancer

Aldosterone has been suggested to elicit vessel contraction via a nongenomic mechanism. We tested this proposal in microdissected, perfused rabbit renal afferent arterioles. Aldosterone had no effect on internal diameter in concentrations from 10(-10) to 10(-5) mol/L, but aldosterone abolished the ability of 100 mmol/L KCl to induce vascular contraction. The inhibitory effect of aldosterone was observed from 1 pmol/L. The inhibitory effect was significant after 5 minutes and maximal after 20 minutes and was fully reversible. Actinomycin D (10(-6) mol/L) prolonged the effect of aldosterone. The effect was abolished by the mineralocorticoid receptor antagonist spironolactone (10(-7) mol/L) but not by the glucocorticoid receptor antagonist mifepristone (10(-6) mol/L). The K+-mediated increase of intracellular calcium concentration in afferent arterioles was not affected by aldosterone. Mineralocorticoid receptor was detected by reverse transcription-polymerase chain reaction and ...

2003-01-01

24

British Library Electronic Table of Contents (United Kingdom)

Purpose The paired-like homeodomain transcription factor 2 (PITX2) gene encodes a transcription factor controlled by the WNT/Dvl/CTNNB1 and Hedgehog/TGFB pathways in the pathogenesis of colorectal cancer (CRC). Although PITX2 is reportedly involved in various functions, including tissue development by controlling cell growth, its significance in CRC remains unclear. We report our findings regarding abnormal PITX2 expression in human CRC. Methods PITX2 expression was evaluated in 5 human CRC cell lines and 92 primary CRC samples. Cell growth was evaluated after inhibition of PITX2 expression or after exogenous introduction of PITX2. Results PITX2 expression was seen in all the five CRC cell lines. The study of tissue samples indicated that PITX2 expression was significantly higher in cancer...

2011-01-01

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Lack of Association of the Genotype in the GNAS Fok I Polymorphism and Prostate Cancer

British Library Electronic Table of Contents (United Kingdom)

Abstract Background: G proteins are ubiquitously expressed signal transduction proteins playing a key role in multiple signal transduction pathways. The Gas subunit has been considered as an apoptosis factor. In this study the role of GNAS T393C genotypes of the GNAS gene encoding Gas was analyzed for its influence on the development and progression of prostate cancer. Methods: Genotyping of the GNAS T393C polymorphism in 196 prostate cancer patients and 200 healthy controls was performed by DNA extraction followed by PCR and restriction analysis. Results: We observed no evidence of effects related to GNAS T393C genotype as demonstrated by a comparison of the genotype distribution in prostate cancer patients and healthy controls, the genotype distribution dependent on grade of the primary ...

2011-01-01

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Systems Biology Approach in Chlamydomonas Reveals Connections between Copper Nutrition and Multiple Metabolic Steps[C][W][OA

Picornavirus Subversion of the Autophagy Pathway

In this work, we query the Chlamydomonas reinhardtii copper regulon at a whole-genome level. Our RNA-Seq data simulation and analysis pipeline validated a 2-fold cutoff and 10 RPKM (reads per kilobase of mappable length per million mapped reads) (~1 mRNA per cell) to reveal 63 CRR1 targets plus another 86 copper-responsive genes. Proteomic and immunoblot analyses captured 25% of the corresponding proteins, whose abundance was also dependent on copper nutrition, validating transcriptional regulation as a major control mechanism for copper signaling in Chlamydomonas. The impact of copper deficiency on the expression of several O2-dependent enzymes included steps in lipid modification pathways. Quantitative lipid profiles indicated increased polyunsaturation of fatty acids on thylakoid membrane digalactosyldiglycerides, indicating a global impact of copper deficiency on the photosynthetic apparatus. Discovery of a putative plastid copper chaperone ...

2011-04-01

27

Dysregulation of the mevalonate pathway promotes transformation

While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates...Full Text Available

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Vascular filtration function in galactose-fed versus diabetic rats: The role of polyol pathway activity

The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding...Full Text Available

2010-08-24

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ERK-dependent and -independent pathways trigger human neural progenitor cell migration

These studies were undertaken to assess the effects of increased galactose (v increased glucose) metabolism via the polyol pathway on vascular filtration function in the kidneys, eyes, nerves, and aorta. Quantitative radiolabeled tracer techniques were used to assess glomerular filtration rate (GFR) and regional tissue vascular clearance of plasma 131I-bovine serum albumin (BSA) in five groups of male Sprague-Dawley rats: nondiabetic controls, streptozotocin-diabetic rats, nondiabetic rats fed a 50% galactose diet, diabetic rats treated with sorbinil (an aldose reductase inhibitor), and galactose-fed rats treated with sorbinil. Sorbinil was added to the diet to provide a daily dose of approximately .2 mmol/kg body weight. After 2 months of diabetes or galactose ingestion, albumin clearance was increased twofold to fourfold in the eye (anterior uvea, choroid, and retina), sciatic nerve, aorta, and kidney; GFR was increased approximately twofold ...

1990-07-01

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RESRAD model presentation

Besides differentiation and apoptosis, cell migration is a basic process in brain development in which neural cells migrate several centimeters within the developing brain before reaching their proper positions and forming the right connections. For identifying signaling events that control neural migration and are therefore potential targets of chemicals to disturb normal brain development, we developed a human neurosphere-based migration assay based on normal human neural progenitor (NHNP) cells, in which the distance is measured that cells wander over time. Applying this assay, we investigated the role of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the regulation of NHNP cell migration. Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration. The participation of phospho-(P-) ERK1/2 was confirmed by exposure of the cells to the MEK inhibitor PD98059, ...

2007-05-15

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Pilot Study of the Treatment of VEGF-Signaling Pathway Inhibitor-Induced Hypertension

RESRAD was one of the multimedia models selected by the US Nuclear Regulatory Commission (NRC) to include in its workshop on radiation dose modeling and demonstration of compliance with the radiological criteria for license termination. This paper is a summary of the presentation made at the workshop and focuses on the 10 questions the NRC distributed to all participants prior to the workshop. The code selection criteria, which were solicited by the NRC, for demonstrating compliance with the license termination rule are also included. Among the RESRAD family of codes, RESRAD and RESRAD-BUILD are designed for evaluating radiological contamination in soils and in buildings. Many documents have been published to support the use of these codes. This paper focuses on these two codes. The pathways considered, the databases and parameters used, quality control and quality assurance, benchmarking, verification and validation of these codes, and ...

1998-05-01

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Manganese-enhanced and diffusion tensor MR imaging of the normal, injured and regenerating rat visual pathway

Treatment Induced Hypertension

2011-01-19

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Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2

Full Text Available

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The kinetic model of the shikimate pathway as a tool to optimize enzyme assays for high-throughput screening.

Udgivelsesdato: 2007/7

2007-01-01

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Disposal of De-ionizer Vessels Highly Contaminated with 14Carbon at SRS

Four-enzyme section of the shikimate pathway (Aro B, D, E, and K) of Streptococcus pneumoniae has been studied. Kinetic properties of the individual enzymes and three- and four-enzyme linked reactions have been characterized in vitro. On the basis of the data measured in spectrophotometric and LC-MS experiments, kinetic mechanisms of the enzymes have been suggested and all kinetic parameters have been identified. Kinetic models for these three- and four-enzyme sections of the shikimate pathway have been constructed and validated. The model of the four-enzyme section of shikimate pathway has been employed to design an inhibition-sensitive reconstituted pathway for a high-throughput screening effort on the shikimate pathway. It was demonstrated that using the model it was possible to optimize this reconstituted pathway in such a way to provide equal sensitivity of ...

2006-11-01

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Maturation of GABAergic Inhibition Promotes Strengthening of Temporally Coherent Inputs among Convergent Pathways

At the Savannah River Site (SRS), nuclear production reactors used de-ionizers to control the chemistry of the reactor moderator during their operation to produce nuclear materials primarily for the weapons program. These de-ionizers were removed from the reactors and stored as a legacy waste with no path to disposal due to the relatively high 14C contamination (i.e., on the order of 20 curies per de-ionizer for 48-50 de-ionizers) and the low disposal limit of 4.2 Ci previously established for the Intermediate Level Vault (ILV). The ILV is considered most appropriate facility within which to dispose these items due to the method of solidifying waste items with cementitious material inside concrete vaults. In previous analyses the 14C ILV disposal limit was established at 4.2 Ci resulting from the use of a very conservative method to analyze the dose received from atmospheric releases of gaseous 14C. This investigation implemented a more rigorous evaluation of the ...

2008-01-01

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The effect of low dose gamma irradiation on the activity of blood serum lysozyme and complement in broiler chickens

Spike-timing-dependent plasticity (STDP), a form of Hebbian plasticity, is inherently stabilizing. Whether and how GABAergic inhibition influences STDP is not well understood. Using a model neuron driven by converging inputs modifiable by STDP, we determined that a sufficient level of inhibition was critical to ensure that temporal coherence (correlation among presynaptic spike times) of synaptic inputs, rather than initial strength or number of inputs within a pathway, controlled postsynaptic spike timing. Inhibition exerted this effect by preferentially reducing synaptic efficacy, the ability of inputs to evoke postsynaptic action potentials, of the less coherent inputs. In visual cortical slices, inhibition potently reduced synaptic efficacy at ages during but not before the critical period of ocular dominance (OD) plasticity. Whole-cell recordings revealed that the amplitude of unitary IPSCs from parvalbumin positive (Pv+) interneurons to ...

2010-06-03

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Report on the International Peer Review of RAINS-ASIA

Samples from 314 broiler chickens at 2 months age were analyzed for blood serum level of lysozyme and 311 of them were analyzed also for activity of alternative path-way of complement activity (APCA). Chickens were hatched from eggs, irradiated immediately before incubation with different doses of gamma-rays using Rocus M device - group 1 - control (non irradiated), and groups 2, 3 and 4 - irradiated with doses of 0.15, 0.30 and 0.60 Gy, respectively. Lysozyme concentration was highest for the control group, and for the experimental ones it was lower (p<0.001) which is an indication of the strongly negative effect of gamma-rays on this indicator. For APCA the oppsite relationship was observed - increasing of its activity with increasing of irradiation dose (from p<0.05 to p<0.001) which gave reason to suggest that this phenomenon is due to the irradiation. 12 refs., 2 tabs. (author).

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Liquid and gaseous effluent control and monitoring at Cernavoda NPP and the assessment of the environmental impact

Many Asian countries have experienced rapid economic growth during recent years and this trend is expected to continue. The economic growth is accompanied by increasing energy demand, with coal as the dominant energy source. For the first time a model has been specifically developed and applied for integrated assessment of future SO{sub 2} emissions in Asia. The report deals with the RAINS-ASIA model developed in Norway offering an opportunity to assess sulphur deposition and ecosystem protection levels resulting from different energy pathways and different emission control strategies. The cost of various control strategies are also provided. During the project an impressive database has been collected for the region (23 countries, 94 subregions and 355 large point sources). This was made possible through dedicated work by the project team, in close collaboration with scientific and technical institutions in several Asian ...

1995-10-01

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A process model of natural attenuation in drainage from a historic mining district

The release of any potential radioactive pollutant to the environment during routine operation of a Nuclear Power Plant should be the subject of appropriate controls and assessments. It is impossible to monitor directly the dose contribution of normal releases because the environmental radioactivity levels are very small but source monitoring provides a means of assessing the radiation exposure of population groups, critical groups and individual members of the public. Derived emissions limits ( DELs ) are used to quantify the relationship between releases of radioactivity and doses to public - critical groups. CNE Cernavoda DELs are based on a pathway analysis conducted for Cernavoda site specific conditions and they were computed using a compartment transfer model. Annual air and water emissions for the most significant radionuclides between 1997 and 2008 are presented in terms of doses and can be observed that population doses are far below ...

2009-10-12

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KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats

A process model was used to better understand the controls on the chemical evolution of drainage in a historic mining district. At the Pecos Mine Operable Unit, New Mexico, drainage near the waste rock pile is acidic (pH varies from 3.0--5.0) and carries high concentrations of Zn, Al, Cu and Pb. As drainage flows toward the Pecos River, pH increases to greater than 7 and heavy metal content decreases. A process model of natural attenuation in this drainage shows the main controls on pH are reaction with a local bedrock that contains limestone, and concurrent mixing with tributary streams. Models that account for both calcite dissolution and mixing reproduce the observed decrease in aqueous metal concentrations with increasing pH. Contaminant concentrations attenuate primarily via two distinct pathways: Al, Cu, Fe and Pb precipitate directly from solution, whereas Zn, Mg, Mn and SO{sub 4} concentrations decrease primarily ...

2000-06-05

42

British Library Electronic Table of Contents (United Kingdom)

Summary: The KEGG PATHWAY database provides a widely used service for metabolic and nonmetabolic pathways. It contains manually drawn pathway maps with information about the genes, reactions and relations contained therein. To store these pathways, KEGG uses KGML, a proprietary XML-format. Parsers and translators are needed to process the pathway maps for usage in other applications and algorithms. We have developed KEGGtranslator, an easy-to-use stand-alone application that can visualize and convert KGML formatted XML-files into multiple output formats. Unlike other translators, KEGGtranslator supports a plethora of output formats, is able to augment the information in translated documents (e.g. MIRIAM annotations) beyond the scope of the KGML document, and amends missing components to fr...

2011-01-01

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Pathway analysis for alternate low-level waste disposal methods

The effect of oxygen and paraquat on the "1"4C-glucose oxidation of rabbit alveolar macrophages and lung slices

The purpose of this paper is to evaluate a complete set of environmental pathways for disposal options and conditions that the Nuclear Regulatory Commission (NRC) may analyze for a low-level radioactive waste (LLW) license application. The regulations pertaining In the past, shallow-land burial has been used for the disposal of low-level radioactive waste. However, with the advent of the State Compact system of LLW disposal, many alternative technologies may be used. The alternative LLW disposal facilities include below- ground vault, tumulus, above-ground vault, shaft, and mine disposal This paper will form the foundation of an update of the previously developed Sandia National Laboratories (SNL)/NRC LLW performance assessment methodology. Based on the pathway assessment for alternative disposal methods, a determination will be made about whether the current methodology can satisfactorily analyze the pathways and phenomena ...

1992-03-01

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skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release.

In this study, we measured the effects of different concentrations of paraquat (0,01 mM and 1,0 mM) on the 1-"1"4CO_2 and 6-"1"4CO_2 production of rabbit lung slices and isolated alveolar macrophages, in 20% and 95% oxygen phases respectively. A 95% oxygen phase induced an increase in the 6-"1"4C-glucose oxidation of control lung slices over a 3-hour period, while the increased activity of the pentose pathway over the first 2 hours started to decline during the third hour of incubation. Paraquat (1,0mM) in 20% oxygen caused a consistent increase in the 6-"1"4CO_2 production by lung slices, but in a 95% oxygen phase gradually inhibited the 6-"1"4C-glucose oxidation over a period of 3 hours. The pentose phosphate pathway was highly significantly stimulated by 1,0 mM paraquat in 20% and 95% oxygen over 3 hours. When isolated alveolar macrophages (viability 95%) were incubated in a 20% and 95% oxygen phase respectively, both ...

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation...Full Text Available

1998-12-01

46

The Requirement for Sodium as a Micronutrient by Species Having the C₄ Dicarboxylic Photosynthetic Pathway

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through...Full Text Available

2011-01-12

47

The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition

Six species having characteristics of plants with the C₄ dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon...Full Text Available

1972-05-01

48

Stabilization of ?-catenin induces pancreas tumor formation

Six genes involved in the heparan sulfate and heparin metabolism pathway, DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1...Full Text Available

49

Select spinal lesions reveal multiple ascending pathways in the rat conveying input from the male genitalia

Background & Aimsβ-catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated...Full Text Available

2008-10-01

50

RXR activators molecular signalling: involvement of a PPAR?-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart

The specific white matter location of all the spinal pathways conveying penile input to the rostral medulla is not known. Our previous studies using rats demonstrated the loss of low but not high threshold...Full Text Available

2010-04-01

51

Pathways, Outcomes, and Costs in Colon Cancer: Retrospective Evaluations in Two Distinct Databases

In this study we compared the molecular signalling elicited by rexinoids, selective retinoid X receptor (RXR)-activators, in several organs (i.e. liver, kidney,...Full Text Available

2003-03-01

52

PDP-1 Links the TGF-? and IIS Pathways to Regulate Longevity, Development, and Metabolism

Purpose:The goal of this study was to use two separate databases to evaluate the clinical outcomes and the economic impact of adherence to Level I Pathways, an evidence-based oncology...Full Text Available

2011-05-01

53

JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

2011-04-01

54

Complement-inhibiting and anti-inflammatory properties of chlorazole fast pink 2BL.

Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Studies conducted over the past 10 to 15 years have revealed that...Full Text Available

2010-10-01

55

Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice

Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be...Full Text Available

1981-02-01

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Preparation of "2"0"3Pb compounds for studies on pathway and effects of lead pollution

AIM: To investigate atrial natriuretic peptide (ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A) pathway and diabetic gastroparesis.METHODS:...Full Text Available

2010-01-07

57

Cholera toxin binding sites in yeast triggers biochemical pathway

... air pollution coprecipitation isotope production lead 203 proton beams

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The influence of electromagnetic field irradiated by high-voltage transmission lines on properties of cells.

... e Biologia Molecular (SBBq), Sao Paulo, SP (Brazil) 217 p. APPLIED LIFE

1998-05-23

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Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients

The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that signal transduction of cell is affected by this electromagnetic field. The spectra of infrared absorption for ...

2005-01-01

60

British Library Electronic Table of Contents (United Kingdom)

Aims: The present study explored the integrative effect of genes encoding methadone pharmacokinetic and pharmacodynamic pathways on methadone maintenance doses in Han Chinese Patients. Materials & methods: Genomic DNA was extracted from 321 opioid-dependent patients and 202 healthy controls, and realtime-PCR and PCR-RFLP were conducted to determine the genotypes. Results: Pair-wise comparisons revealed that carriers of the variants ABCB1 3435C>T or CYP2B6 516G>T alleles were more likely to require a higher methadone dose than noncarriers (both p G or 939C>T allele had a two-fold chance of requiring a lower methadone dose than noncarriers (p = 0.001). Proportional odds regression with adjustment of cofactors demonstrated that ...

2011-01-01

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Genetic engineering of group 2 sigma factor SigE widely activates expressions of sugar catabolic genes in Synechocystis species PCC 6803.

Expression profiles of PtrLOS2 encoding an enolase required for cold-responsive gene transcription from trifoliate orange

Metabolic engineering of photosynthetic organisms is required for utilization of light energy and for reducing carbon emissions.Control of transcriptional regulators is a powerful approach for changing cellular dynamics, because a set of genes is concomitantly regulated. Here, we show that overexpression of a group 2 ? factor, SigE, enhances the expressions of sugar catabolic genes in the unicellular cyanobacterium, Synechocystis sp. PCC 6803. Transcriptome analysis revealed that genes for the oxidative pentose phosphate pathway and glycogen catabolism are induced by overproduction of SigE. Immunoblotting showed that protein levels of sugar catabolic enzymes, such as glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, glycogen phosphorylase, and isoamylase, are increased. Glycogen levels are reduced in the SigE-overexpressing strain grown under light. Metabolome analysis revealed that metabolite levels of the TCA cycle and ...

2011-07-11

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British Library Electronic Table of Contents (United Kingdom)

Low expression of osmotically responsive genes 2 (LOS2) encodes an enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) that converts 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate (PEP) in the glycolytic pathway in Arabidopsis. Meanwhile, it is a transcriptional activator of cold-responsive gene, negatively controlling the expression of STZ/ZAT10, a zinc finger transcriptional repressor of cold-responsive gene from Arabidopsis. A novel LOS2 gene, designated PtrLOS2 (GenBank accession number GQ144341), was isolated from trifoliate orange [Poncirus trifoliata (L.) Raf.]. The PtrLOS2 cDNA is 1 662 bp in length with a 1 338 bp open reading frame (ORF), encoding a deduced 445 amino acid residue protein with a predicted molecular mass of 47.79 kDa and an isoelectric point of 5.54. The ded...

2011-01-01

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Dihydroxybenzene/benzoquinone-containing polymers: organic redox polymers

Defense Threat Reduction Agency Radiochemical Needs

Polymers containing hydroquinone, catechol or their corresponding benzoquinones are a special class of redox polymers. Three pathways of their syntheses are possible: condensation polymerization of suitable monomers, addition polymerization of vinyl monomers containing redox moiety, and chemical attachment of redox unit onto pre-made polymeric matrix. A range of functionalized matrices have been employed such as polyethers, polyesters, polycarbonates, polyurethanes, polyamides and others. Protection of their phenolic functionality has conducted to chemically interesting redox polymer precursors. The presence of a redox moiety coupled with the extant functionalization of the polymer matrix makes the materials very valuable, of wide properties and consequently of vast applicability. For instance, in the oil field, some polymers such as carboxy-methyl-cellulose (CMC) are often applied as to bring about a viscosity improvement and therefore to facilitate the oil ...

2000-08-01

64

Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc

The United States Government (USG) first developed nuclear forensics-related capabilities to analyze radiological and nuclear materials, including underground nuclear test debris and interdicted materials. Nuclear forensics is not a new mission for Department of Defense (DoD). The department's existing nuclear forensics capability is the result of programs that span six (6) decades and includes activities to assess foreign nuclear weapons testing activities, monitor and verify nuclear arms control treaties, and to support intelligence and law enforcement activities. Today, nuclear forensics must support not only weapons programs and nuclear smuggling incidents, but also the scientific analysis and subsequent attribution of terrorists' use of radiological or nuclear materials/devices. Nuclear forensics can help divulge the source of origin of nuclear materials, the type of design for an interdicted or detonated device, as well as the pathway of ...

2009-08-19

65

British Library Electronic Table of Contents (United Kingdom)

Intervertebral disc (IVD) cell apoptosis has been suggested to play an important role in promoting the degeneration process. It has been demonstrated that IVD cell apoptosis occurs through either death receptor, mitochondrial or endoplasmic reticulum (ER) pathway. Our study aimed to explore the relationship among these three pathways and grade of IVD degeneration (IVDD). IVDs were collected from patients with lumbar fracture, vertebral tumor, disc herniation or spondylolisthesis. IVDs were distinguished by MRI and histomorphological examination, cell apoptosis was detected by TUNEL staining. Biomarkers of these three apoptosis pathways were detected by RT-PCR and Western blot. Furthermore, the correlation between apoptosis pathways biomarkers and disc pathology were analyzed. Nucleus pulpo...

2011-01-01

66

SR 97 - Alternative models project. Discrete fracture network modelling for performance assessment of Aberg

On-site radiation exposure in severe reactor accidents: Scoping study

As part of studies into the siting of a deep repository for nuclear waste, Swedish Nuclear Fuel and Waste Management Company (SKB) has commissioned the Alternative Models Project (AMP). The AMP is a comparison of three alternative modeling approaches for geosphere performance assessment for a single hypothetical site. The hypothetical site, arbitrarily named Aberg is based on parameters from the Aespoe Hard Rock Laboratory in southern Sweden. The Aberg model domain, boundary conditions and canister locations are defined as a common reference case to facilitate comparisons between approaches. This report presents the results of a discrete fracture pathways analysis of the Aberg site, within the context of the SR 97 performance assessment exercise. The Aberg discrete fracture network (DFN) site model is based on consensus Aberg parameters related to the Aespoe HRL site. Discrete fracture pathways are identified from canister locations in a ...

1999-08-01

67

The geological structures of gas hydrate occurrence in big gas field of the northern slope of South China Sea

The results of a scoping study of onsite radiation exposures which could take place in each of three types of postulated reactor accidents are presented. The accident types are (1) a fuel handling accident at a Mark III BWR; an interfacing system LOCA or V sequence at a PWR; and and Anticipated Transient Without Scram (ATWS) at a Mark I BWR. Both external and internal dose pathways are considered. The results of the study indicate the prohibitively high radiation doses could be received in some plant areas if personnel were to remain there. However, times of the order of a few minutes to a few hours, depending on the type of accident, would be available before life-threatening doses would be accumulated assuming that the provided full face respiratory protection equipment were used promptly. Special attention was given radiation doses possibly received by control room personnel for several control room air in-leakage ...

1990-09-01

68

The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

The passive continental margin in the northern South China Sea is a weakly active area. It has been found to be favorable for large gas field development and also to be profitable for gas hydrate. The active faults, diapir structure, slump deposits, faults break of slopes, gas chimneys and sandstone of submarine fan, control the concentration of gas hydrate. Gas chimneys are widely distributed in the northern South China Sea. They supply the pathway for migration of deeper gas to gas hydrate stability zones especially in the basin of tectonic inactive zone. This paper discussed the geological structures of gas hydrate occurrence in gas fields and presented a detailed analysis of gas chimneys within the northern slope of the South China Sea. The paper described the geological setting of the Qiongdongnan Basin and provided information on the data description and processing. Two multichannel seismic (MCS) reflection profiles were used for the ...

2008-07-01

69

Temperature stabilization, ocean heat uptake and radiative forcing overshoot profiles

Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.

2010-01-01

70

British Library Electronic Table of Contents (United Kingdom)

Political leaders in numerous nations argue for an upper limit of the global average surface temperature of 2 K above the pre-industrial level, in order to attempt to avoid the most serious impacts of climate change. This paper analyzes what this limit implies in terms of radiative forcing, emissions pathways and abatement costs, for a range of assumptions on rate of ocean heat uptake and climate sensitivity. The primary aim is to analyze the importance of ocean heat uptake for radiative forcing pathways that temporarily overshoot the long-run stabilization forcing, yet keep the temperature increase at or below the 2 K limit. In order to generate such pathways, an integrated climate-economy model, MiMiC, is used, in which the emissions pathways generated represent the least-cost solution o...

2011-01-01

71

Telomeres and telomerase in cancer

Technology Improvement Pathways to Cost-Effective Vehicle Electrification: Preprint

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

2010-01-01

72

Physiology of the Autonomic Nervous System

This paper evaluates several approaches aimed at making plug-in electric vehicles (EV) and plug-in hybrid electric vehicles (PHEVs) cost-effective.

2010-02-01

73

Phenolic compounds in ectomycorrhizal interaction of lignin modified silver birch

This manuscript discusses the physiology of the autonomic nervous system (ANS). The following topics are presented: regulation of activity; efferent pathways; sympathetic and parasympathetic divisions;...Full Text Available

2007-08-15

74

Pathway analysis: aquatic plants imported in 10 EPPO countries

BackgroundThe monolignol biosynthetic pathway interconnects with the biosynthesis of other secondary phenolic metabolites, such as cinnamic acid derivatives, flavonoids and condensed...Full Text Available

75

British Library Electronic Table of Contents (United Kingdom)

Pathway analyses are regarded by National Plant Protection Organizations as a very efficient way to address the risks posed by invasive alien species. Data on import of aquatic plants was obtained from 10 EPPO countries (Austria, Czech Republic, Estonia, France, Germany, Hungary, the Netherlands, Latvia, Switzerland and Turkey) and aggregated in order to consider whether invasive or potentially invasive alien plants could be introduced in the EPPO region through this pathway. This study highlights that this pathway mainly consists of the import of tropical plants for use in aquaria, and which do not represent a risk due to their climatic requirements. However, a few species require thorough attention owing to the threats they cause. Of the 247 species recorded as imported, only 10 are curr...

2009-01-01

76

Oxidation of ethane by an Acremonium species.

Liver Carcinogenesis Unit

Ethane oxidation was studied in ethane-grown resting cells (mycelia) of an Acremonium sp. and in cell-free preparations of such mycelia. From resting cell experiments evidence was found for a pathway...Full Text Available

1976-07-01

77

Genomics of human longevity

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

78

Foodstuff Concentrations and Relocation Considerations Following a Tritium Oxide Release from SRS Tritium Facilities

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

79

Far-out Pathways to Space: Great Guns? - ISTP

The ingestion pathway consequences following an accidental tritium release from the Savannah River Site Tritium Facilities are evaluated.

1999-05-18

80

Far-out Pathways to Space: Great Guns?

The SHARP cannon. Hydrogen is compressed in the tube on top, the gun barrel is on bottom. When Jules Verne wrote in 1865 "From Earth to the Moon" he ...

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81

Characteristics of compounds that cross the blood-brain barrier

Turbine Afterword The SHARP cannon. Hydrogen is compressed in the tube on top, the gun barrel is on bottom. When Jules Verne wrote in 1865 "From Earth to the Moon" he envisioned...

2011-09-03

82

Biosynthesis and metabolism of salicylic acid.

Substances cross the blood-brain barrier (BBB) by a variety of mechanisms. These include transmembrane diffusion, saturable transporters, adsorptive endocytosis, and the extracellular pathways. Here,...Full Text Available

83

Activation of the alternative pathway of complement by mycobacteria and cord factor.

Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

1995-05-09

84

A $G_{4}$ Sequence within PHR1 Promoter Acts as a Gate for Cross-Talks between Damage-Signaling Pathway and Multi-Stress Response

The ability of a number of mycobacteria and some of their components to activate complement was examined. Mycobacterium bovis BCG (Glaxo strain), Mycobacterium leprae, Mycobacterium lepraemurium, and...Full Text Available

1980-07-01

85

Synergistic Activation of Glucose-6-Phosphate Dehydrogenase and NAD(P)H oxidase by Src kinase Elevates Superoxide in Type 2 Diabetic, Zucker fa/fa, Rat Liver

Full Text Available

2002-09-01

86

Regulation of Indole-3-Acetic Acid Biosynthetic Pathways in Carrot Cell Cultures ¹

Glucose metabolism through glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, its fate through the pentose phosphate pathway (PPP) is currently unclear....Full Text Available

2009-08-01

87

Differential regulation of the biosynthesis of glucose transporters by the PI3-K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla.

2,4-Dichlorophenoxyacetic acid (2,4-D) promotes the accumulation of tryptophan-derived indole-3-acetic acid (IAA) in carrot cell cultures during callus proliferation by a biosynthetic pathway that is...Full Text Available

1992-11-01

88

Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila

The insulin signaling pathway, involving protein kinase B (PKB) and mitogen-activated protein kinase (MAPK), mediates the biological response to insulin and several growth factors and cytokines. To investigate the correlation between glucose transporter (Glut) biosynthesis and the insulin signaling pathway activated by novel compounds of Liriope platyphylla (LP9M80-H), alterations in Glut and key protein expression in the insulin signaling pathway were analyzed in the liver and brain of ICR mice treated with LP9M80-H. An in vitro assay showed that the highest level of insulin concentration was observed in the LP9M80-H-treated group, followed by the LP-H, LP-M, LP-E, and LP9M80-C-treated groups. Therefore, LP9M80-H was selected for use in studying the detailed mechanism of the insulin signaling pathway in animal systems. In an in vivo experiment, LP9M80-H induced a significant increase in glucose levels ...

2010-12-14

89

The requirement for sodium as a micronutrient by species having the c(4) dicarboxylic photosynthetic pathway.

A multiple comparison approach using whole genome transcriptional arrays was used to identify genes and pathways involved in calorie restriction/dietary restriction (DR) life span extension in Drosophila....Full Text Available

2011-03-15

90

The Requirement for Sodium as a Micronutrient by Species Having the C4 Dicarboxylic Photosynthetic Pathway

Six species having characteristics of plants with the C(4) dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon L. (Bermuda grass), Kyllinga brevifolia Rottb., Amaranthus tricolor L. cv. Early splendour, Kochia childsii Hort., and Portulaca grandiflora Hook (rose moss), responded decisively to 0.1 milliequivalent per liter NaCl supplied to their culture solutions initially containing less than 0.08 microequivalent per liter Na. Chlorosis and necrosis occurred in leaves of plants not receiving sodium. Portulaca failed to set flower in the sodium-deficient cultures. Under similar conditions Poa pratensis L. (Kentucky blue grass) having characteristics of the C(3) photosynthetic pathway made normal growth and did not respond to the addition of sodium. It is concluded from these results and previously reported work that sodium is generally essential for species having the C(4) ...

1972-05-01

91

UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1

Six species having characteristics of plants with the C4 dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon L. (Bermuda grass), Kyllinga brevifolia Rottb., Amaranthus tricolor L. cv. Early splendour, Kochia childsii Hort., and Portulaca grandiflora Hook (rose moss), responded decisively to 0.1 milliequivalent per liter NaCl supplied to their culture solutions initially containing less than 0.08 microequivalent per liter Na. Chlorosis and necrosis occurred in leaves of plants not receiving sodium. Portulaca failed to set flower in the sodium-deficient cultures. Under similar conditions Poa pratensis L. (Kentucky blue grass) having characteristics of the C3 photosynthetic pathway made normal growth and did not respond to the addition of sodium. It is concluded from these results and previously reported work that sodium is generally essential for species having the C4 ...

1972-01-01

92

UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1

This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for contaminants to reach the environment during ...

2004-06-22

93

Shape evolution of nanostructures by thermal and ion beam processing. Modeling and atomistic simulations

This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for contaminants to reach the environment during ...

1995-10-01

94

Regulation of the phosphoinositide pathway in cultured Sertoli cells from immature rats: effects of follicle-stimulating hormone and fluoride

Single-crystalline nanostructures often exhibit gradients of surface (and/or interface) curvature that emerge from fabrication and growth processes or from thermal fluctuations. Thus, the system-inherent capillary force can initiate morphological transformations during further processing steps or during operation at elevated temperature. Therefore and because of the ongoing miniaturization of functional structures which causes a general rise in surface-to-volume ratios, solid-state capillary phenomena will become increasingly important: On the one hand diffusion-mediated capillary processes can be of practical use in view of non-conventional nanostructure fabrication methods based on self-organization mechanisms, on the other hand they can destroy the integrity of nanostructures which can go along with the failure of functionality. Additionally, capillarity-induced shape transformations are effected and can thereby be controlled by applied fields and forces (guided ...

2009-05-12

95

Pyridoxine dependent epilepsy and antiquitin deficiency Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.

Many hormones elicit effects on target cells by stimulating the enzyme phospholipase-C, which catalyzes the hydrolysis of phosphoinositides to the intracellular second messengers diacylglycerol and inositol phosphates. The present study examined the roles of FSH and guanine nucleotide-binding proteins (G-proteins) in regulating the hydrolysis of phosphoinositides in Sertoli cells. Sertoli cell cultures prepared from 16- to 18-day-old rats were incubated for 24 h with myo-[2-3H] inositol to label endogenous phospholipids. Treatment of cells from 0.5-20 min with preparations of ovine FSH ranging in potency from 1-60 times that of NIH FSH S1 did not affect accumulation of inositol phosphates. Levels of total [3H]inositol phosphates [[3H]inositol mono-, di-, and triphosphates (IP, IP2, and IP3)] in FSH-treated cultures was 75-120% the levels in control cultures over the various time intervals studied. Addition of testosterone and the combination of testosterone plus ...

96

N"v"a"r"-"e"p"s"i"l"o"n-acetyl-#beta#-lysine: An osmolyte synthesized by mothanogenic archaebacteria

Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of ?-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, treatment with oral/enteral ...

2011-05-24

97

Effects of amifostine on radiation-induced apoptosis in mouse ovary

Methanosarcina thermophila, a nonmarine methanogenic archaebacterium, can grow in a range of saline concentrations. At less than 0.4 M NaCl, Ms. thermophila accumulated glutamate in response to increasing osmotic stress. At greater than 0.4 M NaCl, this organism synthesized a modified #beta#-amino acid that was identified as N"v"a"r"-"e"p"s"i"l"o"n-acetyl-#beta#-lysine by NMR spectroscopy and ion-exchange HPLC. This #beta#-amino acid derivative accumulated to high intracellular concentrations (up to 0.6 M) in Ms. thermophila and in another methanogen examined - Methanogenium cariaci, a marine species. The compound has features that are characteristic of a compatible solute: it is neutrally charged at physiological pH and it is highly soluble. When the cells were grown in the presence of exogenous glycine betaine, a physiological pH and it is highly soluble. When the cells were grown in the presence of exogenous glycine betaine, a physiological compatible solute, ...

98

Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana

The present study was designed to assess the radioprotective effects of amifostine on ovarian follicles. Three week-old female mice with or without pretreatment of amifostine were irradiated with 6.42 Gy of #gamma# -ray. Ovaries were collected 0 and 6h after irradiation. DNA fragmentation pattern and expression of genes and activity of proteins related with apoptosis were investigated by means of RT-PCR and Western blot. Proliferation of granulosa cells was reduced and incidence rate of follicular atresia was increased in ovarian follicles in #gamma# -ray irradiated mice compared to those in control or amifostine-treated group. DNA fragmentation was increased in time-dependent manner in granulosa cells of all irradiated groups. However, no difference between amifostine pre-treated group and irradiated groups was found and the expression of p53 as tumor suppressor gene and Bax as one of pro-apoptotic Bcl-2 family was increased in irradiated mice ovaries. PARP as DNA ...

2002-10-20

99

Assimilation of cadmium, chromium, and zinc by the green mussel Perna viridis and the clam Ruditapes philippinarum

The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values were drawn. Sensitivity analyses of the steady-state model showed ...

1994-04-29

100

A rapid response air quality analysis system for use in projects having stringent quality assurance requirements

The green mussel Perna viridis and the clam Ruditapes philippinarum have been frequently used as biomonitors of coastal contamination in subtropical and tropical waters, yet the physiological processes controlling metal uptake in these bivalves are unknown. Assimilation efficiency (AE) is an important physiological parameter quantifying metal bioavailability from ingested food. The authors determined the AEs of Cd, CR, and Zn in these bivalves feeding on five species of phytoplankton and one natural section. The influences of the cytoplasmic distribution of metals in the algal cells and the digestive physiology of bivalves on metal AEs were also examined. Among the three metals, Zn was generally assimilated at the highest efficiency, i.e., 21 to 36% in the mussels and 29 to 59% in the clams. Cr was the least assimilated metal, with AEs being 10 to 16% in the mussels and 11 to 24% in the clams. The AEs of Cd and Zn in the clams were 1.8 to 4.7 and 1.1 to 1.9 times ...

2000-06-01

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101

Role-based access control

This paper describes an approach to solve air quality problems which frequently occur during iterations of the baseline change process. From a schedule standpoint, it is desirable to perform this evaluation in as short a time as possible while budgetary pressures limit the size of the staff available to do the work. Without a method in place to deal with baseline change proposal requests the environment analysts may not be able to produce the analysis results in the time frame expected. Using a concept called the Rapid Response Air Quality Analysis System (RAAS), the problems of timing and cost become tractable. The system could be adapted to assess other atmospheric pathway impacts, e.g., acoustics or visibility. The air quality analysis system used to perform the EA analysis (EA) for the Salt Repository Project (part of the Civilian Radioactive Waste Management Program), and later to evaluate the consequences of proposed baseline changes, consists of three ...

102

Frequency Controlled Electric Drives

Role-based access control

2007-01-01

103

Control of Influenza A Virus Infection

Development of Frequency Controlled Electric Drives

104

Quantum-chemical investigation of mechanism of dehydroxylation of crystalline and amorphous aluminosilicates

Control of Influenza A Virus Infection

105

Care programmes and integrated care pathways

Within the framework of the cluster approach and the semiempirical SCF MO LCAO method in the CNDO/BW valence approximation, possible pathways have been compared for the dehydroxylation of aluminosilicate systems. It has been shown that dehydroxylation as a result of splitting of a water molecule from an acidic bridge hydroxyl group and a more basic terminal group Al-OH is the most energyfavorable. Apparently, such a dehydroxylation pathway is primarily characteristic for amorphous aluminosilicates. Typical of crystalline aluminosilicates at moderate heat-treating temperature is dehydroxylation through splitting of a water molecule from an acidic bridge hydroxyl group and a neutral Si-OH group; at higher temperatures, there is a possible pathway of dehydroxylation of highsilica zeolites as a result of condensation of two acidic surface hydroxyls.

1986-07-01

106

British Library Electronic Table of Contents (United Kingdom)

Purpose - The article discusses how care programmes and integrated care pathways can be linked, finding ways to improve healthcare process professional and logistical quality from a supply chain and a network point-of-view. Design/methodology/approach - The authors argue that owing to cost containment goals and increasing healthcare demand, healthcare services systems are challenged to improve service quality, whilst at the same time finding ways to improve delivery processes. It explores if the combination of two instruments, care programmes and integrated care pathways, can meet both goals. This combination is illustrated by an example from the Institute of Mental Health Care Eindhoven en de Kempen. Findings - Analysis suggests that care programmes can be combined with integrated care pa...

2008-01-01

107

Ag/C nanoparticles as an cathode catalyst for a zinc-air battery with a flowing alkaline electrolyte

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-? Signaling Through SMAD2 in a ?-Catenin-Dependent Manner

The cyclic voltammetry indicated that the oxygen reduction reaction (ORR) proceeded by the four-electron pathway mechanism on larger Ag particles (174 nm), and that the ORR proceeded by the four-electron pathway and the two-electron pathway mechanisms on finer Ag particles (4.1 nm), simultaneously. The kinetics towards ORR was measured at a rotating disk electrode (RDE) with Ag/C electrode. The number of exchanged electrons for the ORR was found to be close to four on larger Ag particles (174 nm) and close to three on finer Ag particles (4.1 nm). The zinc-air battery with Ag/C catalysts (25.9 nm) was fabricated and examined. (author)

2009-09-05

108

VAGUS NERVE STIMULATION REGULATES HEMOSTASIS IN SWINE

Growing evidence suggests the Wnt family of secreted glycoproteins and their associated signaling pathways, linked to development, are recapitulated during wound repair and regeneration events. However,...Full Text Available

109

Use of Forward Genetics to Discover Novel Regulators of NF-?B

The central nervous system regulates peripheral immune responses via the vagus nerve, the primary neural component of the cholinergic anti-inflammatory pathway. Electrical stimulation of the...Full Text Available

2010-06-01

110

Uptake of injected 125I-ricin by rat liver in vivo. Subcellular distribution and characterization of the internalized ligand.

Forward and reverse genetic experiments have both played important roles in revealing critical aspects of mammalian signal transduction pathways in cell culture experiments. Only recently have we begun...Full Text Available

2010-06-01

111

Tumour suppressor ING1b maintains genomic stability upon replication stress

Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available

1992-05-15

112

Towards computational prediction of microRNA function and activity

The lesion bypass pathway, which is regulated by monoubiquitination of proliferating cell nuclear antigen (PCNA), is essential for resolving replication stalling due to DNA lesions. This process is...Full Text Available

2011-05-01

113

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

While it has been established that microRNAs (miRNAs) play key roles throughout development and are dysregulated in many human pathologies, the specific processes and pathways regulated by individual...Full Text Available

2010-08-01

114

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

Temperature sensing is crucial for homeotherms, including human beings, to maintain a stable body core temperature and respond to the ambient environment. A group of exquisitely temperature-sensitive...Full Text Available

2010-04-13

115

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

Purpose of ReviewThe vertebrate cap’n’collar family transcription factor Nrf2 and its invertebrate homologs SKN-1 (in worms) and CncC (in flies) function...Full Text Available

2011-01-01

116

The mitochondrial p53 pathway

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200...Full Text Available

2009-07-01

117

The inhibition of tumor cell intravasation and subsequent metastasis through the regulation of in vivo tumor cell motility by the tetraspanin CD151

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array...Full Text Available

2009-05-01

118

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

SummaryIn vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo...Full Text Available

2008-03-01

119

The brown adipocyte differentiation pathway in birds: An evolutionary road not taken

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

120

The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/?-Catenin Signaling*

BackgroundThermogenic brown adipose tissue has never been described in birds or other non-mammalian vertebrates. Brown adipocytes in mammals are distinguished from the more common...Full Text Available

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121

The Organizational Hypothesis and Final Common Pathways: Sexual Differentiation of the Spinal Cord and PeripheralNervous System

The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available

2008-11-28

122

Targeting the p53 Pathway in Ewing Sarcoma

In honor of the 50^th anniversary of the “organizational hypothesis,” this paper reviews work on sexual differentiation of the spinal cord and peripheral nervous system....Full Text Available

2009-05-01

123

Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available

2011-01-01

124

Synergistic Operation of the CAR2 (Ornithine Transaminase) Promoter Elements in Saccharomyces cerevisiae

Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance,...Full Text Available

2010-05-01

125

Synapse-Associated Protein 102/dlgh3 Couples the NMDA Receptor to Specific Plasticity Pathways and Learning Strategies

Dal82p binds to the UIS_ALL sites of allophanate-induced genes of the allantoin-degradative pathway and functions synergistically with the GATA family Gln3p and Gat1p transcriptional...Full Text Available

1999-11-01

126

Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis

Understanding the mechanisms whereby information encoded within patterns of action potentials is deciphered by neurons is central to cognitive psychology. The multiprotein complexes formed by...Full Text Available

2007-03-07

127

Structural Characterization and Expression Analysis of the SERK/SERL Gene Family in Rice (Oryza sativa)

Cysticercosis is an infection with larval cysts of the cestode Taenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that,...Full Text Available

2010-01-01

128

Soluble Variants of Rhodobacter capsulatus Membrane-anchored Cytochrome c_y Are Efficient Photosynthetic Electron Carriers*

Somatic embryogenesis (SE) is the developmental restructuring of somatic cells towards the embryogenic pathway and forms the basis of cellular totipotency in angiosperms. With the availability of full-length...Full Text Available

2009-01-01

129

Scientists seek to turn methanol glut to profit

Photosynthetic (Ps) electron transport pathways often contain multiple electron carriers with overlapping functions. Here we focus on two c-type cytochromes (cyt) in facultative phototrophic...Full Text Available

2008-05-16

130

Regulation of Energy Metabolism Pathways by Estrogens and Estrogenic Chemicals and Potential Implications in Obesity Associated with Increased Exposure to Endocrine Disruptors

French scientists think they have discovered one of the key steps in the methanol-to-gasoline reaction pathway and their British counterparts have learned a new way of converting methanol into acetic acid without carbon monoxide.

1984-11-18

131

Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells

The prevalence of obesity among children, adolescents and adults has been dramatically increasing worldwide during the last several decades. The obesity epidemic has been recognized as one of...Full Text Available

2009-07-01

132

Prostaglandin-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum

The ubiquitin–proteasome pathway is the principal system for extralysosomal protein degradation in eukaryotic cells, and is essential for the regulation and maintenance of basic cellular processes,...Full Text Available

2007-01-01

133

Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex

SUMMARYSmall bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair as function recovers...Full Text Available

2003-11-01

134

Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain

Rapamycin inhibits the mTOR (target of rapamycin) pathway and extends lifespan in multiple species. The tuberous sclerosis complex (TSC) protein is a negative regulator of mTOR. In humans, loss of the...Full Text Available

135

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

Previous studies in several different trigeminal nerve injury/inflammation models indicated that the hyperexcitability of primary afferent neurons contributes to the pain pathway underlying mechanical...Full Text Available

136

Pathway to Licensure for Protective Antigen-based Anthrax Vaccines ...

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

137

Pathway of Sugar Transport in Germinating Wheat Seeds

... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

138

PGM2 overexpression improves anaerobic galactose fermentation in Saccharomyces cerevisiae

Three homeologous genes encoding a sucrose (Suc) transporter (SUT) in hexaploid wheat (Triticum aestivum), TaSUT1A, 1B, and 1D, were...Full Text Available

2006-08-01

139

Opposing function of mitochondrial prohibitin in aging

BackgroundIn Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose...Full Text Available

140

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice

While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless,...Full Text Available

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141

NASA Materials, Structures, Mechanical Systems, & Manufacturing ...

OBJECTIVE—Identification of arterial genes and pathways altered in obesity and diabetes.RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of...Full Text Available

2008-10-01

142

Molecular mechanisms of genetic adaptation to xenobiotic compounds.

considers a wide range of pathways to advance the nation's current capabilities. The present ... opment of new energy sources, aging infrastruc- ture and ... and manufacturing TA strategic roadmap as brief- ..... pellant storage and transport. ...

143

NAME=\\

Wastenet

...this pathway study the following two focus modules (in addition to the six core modules) and carry out a research investigation within this theme: Agricultural Production Systems Considers the type of farming systems that have evolved globally in relation to the prevailing agro-climatic zones, the influences of economic factors ...

144

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

Microorganisms in the environment can often adapt to use xenobiotic chemicals as novel growth and energy substrates. Specialized enzyme systems and metabolic pathways for the degradation of man-made...Full Text Available

1992-12-01

145

Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq

BackgroundThe zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are...Full Text Available

146

BackgroundIsopentenyl diphosphate (IPP), a common biosynthetic precursor to the labdane diterpene forskolin, has been biosynthesised via a non-mevalonate pathway. Geranylgeranyl...Full Text Available

147

Metabolism of Cytokinin

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

As part of the study of cytokinin metabolic pathways, an enzyme, adenosine phosphorylase (EC 2.4.2.-), which catalyzed the ribosylation of N⁶-(Δ²-isopentenyl)adenine,...Full Text Available

1978-12-01

148

Maturation of GABAergic Inhibition Promotes Strengthening of Temporally Coherent Inputs among Convergent Pathways

Melanoma is one of the most aggressive cancers, and its incidence is increasing. These tumors derive from the melanocyte lineage and remain incurable after metastasis. Here we report that SONIC HEDGEHOG...Full Text Available

2007-04-03

149

Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome

Spike-timing-dependent plasticity (STDP), a form of Hebbian plasticity, is inherently stabilizing. Whether and how GABAergic inhibition influences STDP is not well understood. Using a model neuron driven...Full Text Available

2010-06-01

150

Lnk constrains myeloproliferative diseases in mice

The identification of predictive biomarkers is at the core of modern toxicology. So far, a number of approaches have been proposed. These rely on statistical inference of toxicity response from either...Full Text Available

151

Late onset muscle plasticity in the whisker pad of enucleated rats

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling,...Full Text Available

2010-06-01

152

Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population

Blindness leads to a major reorganization of neural pathways associated with touch. Because incoming somatosensory information influences motor output, it is plausible that motor plasticity occurs in...Full Text Available

2008-10-14

153

Involvement of the NF-?B pathway in multidrug resistance induced by HBx in a hepatoma cell line.

Dysregulation of the alternative pathway of complement activation, caused by mutations or polymorphisms in the genes encoding factor H, membrane co-factor protein, factor I or factor B, is associated...Full Text Available

2009-01-01

154

Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis.

Summary.? It is widely believed that hepatocellular cancer (HCC), especially HBV associated HCC, is highly resistant to chemotherapy. To investigate the molecular influence of HBx protein on multidrug resistance (MDR) in HCC and the potential role of the NF-?B pathway in this process. We established HBx-expressing cells by liposome-mediated transfection of the HBx into the HepG2 cell line. We found that HBx expression in HCC cells induces drug resistance against multiple drugs, a significantly lower apoptosis ratio in HepG2-HBx and HepG2.2.15 cells, compared with HepG2 and HepG2-3.1 cells (P?HCC cells were downregulated by IMD-0354 treatment, which is the NF-?B pathway inhibitor. Taken together, these results suggest that HBx protein might be one of the causes for the occurrence of MDR in HCC, and the NF-?B pathway might be involved in this change. PMID:21914061

2011-05-27

155

Intermediates of Salicylic Acid Biosynthesis in Tobacco1

All molybdenum enzymes except nitrogenase contain a common molybdenum cofactor, whose organic moiety is a novel pterin called molybdopterin (MPT). To assist in elucidating the biosynthetic pathway of...Full Text Available

1987-01-01

156

In vivo expression and mitochondrial targeting of yeast apoiso-1-cytochrome c fusion proteins.

Salicylic acid (SA) is an important component of systemic-acquired resistance in plants. It is synthesized from benzoic acid (BA) as part of the phenylpropanoid pathway. Benzaldehyde (BD), a potential...Full Text Available

1998-10-01

157

In Vivo Reconstitution of ?-Secretase in Drosophila Results in Substrate Specificity?

To define the import pathway for apoiso-1-cytochrome c in vivo, the coding region for bacterial chloramphenicol acetyltransferase (CAT) or yeast copper metallothionein (CuMT) was fused to the carboxy...Full Text Available

1990-11-01

158

Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture

The intramembrane aspartyl protease γ-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases,...Full Text Available

2010-07-01

159

Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis

During a study on the mTor pathway in the rat kidney we observed a striking increase of the phosphorylation of the S6 kinase in mitosis. In cryostat sections of perfusion-fixed tissue mitotic cells...Full Text Available

2007-02-01

160

Hierarchical and serial processing in the spatial auditory cortical pathway is degraded by natural aging

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

2004-10-12

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

Heterogeneity of the supramammillary-hippocampal pathways: Evidence for a unique GABAergic neurotransmitter phenotype and regional differences

The compromised abilities to localize sounds and to understand speech are two hallmark deficits in aged individuals. The auditory cortex is necessary for these processes, yet we know little...Full Text Available

2010-11-03

162

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis

The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore...Full Text Available

2010-09-01

163

Genetic Heterogeneity in Severe Congenital Neutropenia: How Many Aberrant Pathways Can Kill a Neutrophil?

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent...Full Text Available

2010-05-01

164

Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

2007-12-01

165

Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes

Exteriorized phosphatidylserine (PS) residues in apoptotic cells trigger rapid phagocytosis by macrophage scavenger receptor pathways. Mimicking apoptosis with liposomes containing PS may represent...Full Text Available

2009-11-01

166

Evolution and Optimality of Similar Neural Mechanisms for Perception and Action during Search

All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can be traced down to a single endosymbiotic event between two probably prokaryotic organisms. Subsequent evolution...Full Text Available

2010-03-12

167

Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency

A prevailing theory proposes that the brain's two visual pathways, the ventral and dorsal, lead to differing visual processing and world representations for conscious perception than those for action....Full Text Available

2010-09-01

168

Enhanced Levels of the Aroma and Flavor Compound S-Linalool by Metabolic Engineering of the Terpenoid Pathway in Tomato Fruits1

BackgroundNeurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1....Full Text Available

169

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Anti-Lipogenic Therapy

The aromas of fruits, vegetables, and flowers are mixtures of volatile metabolites, often present in parts per billion levels or less. We show here that tomato (Lycopersicon esculentum...Full Text Available

2001-11-01

170

Differential Regulation of Mitogen-Activated Protein Kinase Pathways by Acetaminophen and Its Nonhepatotoxic Regioisomer 3?-Hydroxyacetanilide in TAMH Cells

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma,...Full Text Available

171

Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer

Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States....Full Text Available

2010-07-01

172

Defects in the Secretory Pathway and High Ca²⁺ Induce Multiple P-bodies

The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available

2010-09-01

173

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

mRNA is sequestered and turned over in cytoplasmic processing bodies (PBs), which are induced by various cellular stresses. Unexpectedly, in Saccharomyces cerevisiae, mutants of the...Full Text Available

2010-08-01

174

Citrate Uptake in Exchange with Intermediates in the Citrate Metabolic Pathway in Lactococcus lactis IL1403?

BackgroundMammalian antimicrobial peptides (AMPs) are effectors of the innate immune response. A multitude of signals coming from pathways of mammalian pathogen/pattern recognition...Full Text Available

175

Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons

Carbohydrate/citrate cometabolism in Lactococcus lactis results in the formation of the flavor compound acetoin. Resting cells of strain IL1403(pFL3) rapidly consumed citrate while...Full Text Available

2011-02-01

176

Catabolite Repression of the Citrate Fermentation Genes in Klebsiella pneumoniae: Evidence for Involvement of the Cyclic AMP Receptor Protein

The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation....Full Text Available

2009-12-29

177

Carotenoid Crystal Formation in Arabidopsis and Carrot Roots Caused by Increased Phytoene Synthase Protein Levels

Klebsiella pneumoniae is able to grow anaerobically with citrate as a sole carbon and energy source by a fermentative pathway involving the Na⁺-dependent citrate...Full Text Available

2001-09-01

178

CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

179

Biosynthetic Pathway of Insect Juvenile Hormone III in Cell Suspension Cultures of the Sedge Cyperus iria1

Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD). In the course of experiments using CID755673, we noticed that it exerted unexpected stimulatory...Full Text Available

2010-01-01

180

Betaxanthins as Substrates for Tyrosinase. An Approach to the Role of Tyrosinase in the Biosynthetic Pathway of Betalains1

In most insect species, juvenile hormones regulate critical physiological processes such as metamorphosis and reproduction. In insects, these sesquiterpenoids are synthesized by retrocerebral endocrine...Full Text Available

2001-10-01

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181

BFL: a node and edge betweenness based fast layout algorithm for large scale networks

Tyrosinase or polyphenol oxidase (EC 1.14.18.1) is the key enzyme in melanin biosynthesis and in the enzymatic browning of fruits and vegetables. The role of tyrosinase in the secondary metabolism of...Full Text Available

2005-05-01

182

Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae

BackgroundNetwork visualization would serve as a useful first step for analysis. However, current graph layout algorithms for biological pathways are insensitive to biologically...Full Text Available

183

Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis

Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response...Full Text Available

2010-07-01

184

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M₁ Acetylcholine Receptor StimulationS?

IntroductionBRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known...Full Text Available

2010-01-01

185

Aspartate Carbamyltransferase 1

Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available

2010-01-01

186

Arabidopsis thaliana auxotrophs reveal a tryptophan-independent biosynthetic pathway for indole-3-acetic acid.

Lovatt et al. (1979 Plant Physiol 64: 562-569) have previously demonstrated that end-product inhibition functions as a mechanism regulating the activity of the orotic acid pathway in...Full Text Available

1984-07-01

187

Anxiety in Patients with Cardiac Disease.

We used tryptophan auxotrophs of the dicot Arabidopsis thaliana (wall cress) to determine whether tryptophan has the capacity to serve as a precursor to the auxin, indole-3-acetic acid (IAA). Quantitative...Full Text Available

1993-11-01

188

Analyzing the Light Energy Distribution in the Photosynthetic Apparatus of C4 Plants Using Highly Purified Mesophyll and Bundle-Sheath Thylakoids.

Anxiety may cause adverse outcomes through physiologic pathways in patients with cardiac disease. The purpose of this dissertation was to investigate anxiety and its correlates in persons with acute myocardial infarction (AMI) and heart failure (HF). The ...

2005-01-01

189

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

The chlorophyll fluorescence characteristics of mesophyll and bundle-sheath thylakoids from plant species with the C4 dicarboxylic acid pathway of photosynthesis were investigated using flow cytometry....Full Text Available

1996-11-01

190

Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

191

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Atherosclerosis is an inflammatory process leading to enhanced cellular proliferation, apoptosis, and vasa vasorum (VV) neovascularization. While both diabetes mellitus (DM) and hypercholesterolemia...Full Text Available

2010-09-01

192

Activation of the alternate complement pathway in Staph. aureus infective endocarditis and its relationship to thrombocytopenia, coagulation abnormalities, and acute glomerulonephritis.

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

2011-05-01

193

ALTERATION OF THE PKC-MEDIATED SIGNALING PATHWAY FOR SMOOTH MUSCLE CONTRACTION IN OBSTRUCTION-INDUCED HYPERTROPHY OF THE URINARY BLADDER

Twenty-four patients with infective endocarditis (IE) are described, fourteen with Staph. aureus and ten with other organisms. Despite the acute nature of the infection, ten of the fourteen with Staph....Full Text Available

1978-11-01

194

?Activation of the mitogen-activated protein kinase pathways by heat shock

Normal urinary bladder function requires contraction and relaxation of the detrusor smooth muscle (DSM). The DSM undergoes compensatory hypertrophy in response to partial bladder outlet obstruction...Full Text Available

2009-07-01

195

Regulation of Redd1 Expression by Hypoxia

In addition to inducing new transcriptional activities that lead within a few hours to the accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major signaling transduction...Full Text Available

2002-04-01

196

Reaction pathways of the dissociation of methylal: A DFT study

Redd1, a recently discovered stress-response gene, is regulated by hypoxia via hypoxia-inducible factor 1 (HIF-1) and by DNA damage via p53/p63; however, the signaling pathway by which its expression is induced by hypoxia has not been elucidated. We demonstrated that the up-regulation of Redd1 transcription by hypoxia and high cell density (HCD) depends on cooperation between Sp1 and HIF-1#alpha# downstream of the PI3K/Akt pathway.

2006-05-25

197

Overview of macroautophagy regulation in mammalian cells

Schemata for modelling combustion processes do not yet include reaction rates for oxygenated fuels like methylal (DMM) which is considered as an additive or replacement for diesel due to its low sooting propensity. Density functional theory (DFT) studies of the possible reaction pathways for different dissociation steps of methylal are presented. Cleavage of a hydrogen bond to the methoxy group or the central carbon atom were simulated at the BLYP/6-311++G{sup **} level of theory. The results are compared to the experiment when dissociating and/or ionising DMM with femtosecond pulses. (author) 1 fig., 1 tab., 1 ref.

1999-08-01

198

British Library Electronic Table of Contents (United Kingdom)

Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light of recent advances in our understanding of the formation of autophagosomes, which are double-membrane-bound vacuoles that sequester cytoplasmic cargos and deliver them to lysosomes. In most cases, this final step is preceded by a maturation step during which autophagosomes interact with the endocytic pathway. The discovery of AuTophaGy-related genes has greatly increased our knowledge about the mechanism responsible for autophagosome formation, and there has also been progress in the understanding of molecular aspects of autophagosome maturation. Finally, the regulation of au...

2010-01-01

199

Aquatic pathways model to predict the fate of phenolic compounds

Title of paper: the induction of P-53 independent programmed cell death (apoptosis) with ionizing radiation and 5-fluorouracil (5-FU) in the HT-29 human colon carcinoma cell line

Organic materials released from energy-related activities could affect human health and the environment. To better assess possible impacts, we developed a model to predict the fate of spills or discharges of pollutants into flowing or static bodies of fresh water. A computer code, Aquatic Pathways Model (APM), was written to implement the model. The computer programs use compartmental analysis to simulate aquatic ecosystems. The APM estimates the concentrations of chemicals in fish tissue, water and sediment, and is therefore useful for assessing exposure to humans through aquatic pathways. The APM will consider any aquatic pathway for which the user has transport data. Additionally, APM will estimate transport rates from physical and chemical properties of chemicals between several key compartments. The major pathways considered are biodegradation, fish and sediment uptake, photolysis, and evaporation. ...

1983-04-01

200

Simulating physiological conditions to evaluate nanoparticles for magnetic fluid hyperthermia (MFH) therapy applications

Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 cells were assessed for clonogenic survival ...

1996-09-01

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201

Modulation of neuronal differentiation by CD40 isoforms

Magnetite nanoparticles with high self-heating capacity and low toxicity characteristics are a promising candidate for cancer hyperthermia treatment. In order to achieve minimum dosage to a patient, magnetic nanoparticles with high heating capacity are needed. In addition, the influence of physiological factors on the heat capacity of a material should be investigated in order to determine the feasibility. In this study, magnetite nanoparticles coated with lauric acid were prepared by co-precipitation of Fe{sup 3+}:Fe{sup 2+} in a ratio of 2:1, 5:3, 3:2, and 4:3, and the pH was controlled using NaOH. Structural and magnetization characterization by means of X-ray diffractometry (XRD) and a superconducting quantum interference device (SQUID) revealed that the main species was Fe{sub 3}O{sub 4} and further showed that most of the nanoparticles exhibited superparamagnetic properties. All of the magnetic nanoparticles showed a specific absorption rate (SAR) increase ...

2010-01-15

202

Fluidic-controlled automatic rabbit system

Neuron differentiation is a complex process involving various cell-cell interactions, and multiple signaling pathways. We showed previously that CD40 is expressed and functional on mouse and human neurons. In neurons, ligation of CD40 protects against serum withdrawal-induced injury and plays a role in survival and differentiation. CD40 deficient mice display neuron dysfunction, aberrant neuron morphologic changes, and associated gross brain abnormalities. Previous studies by Tone and colleagues suggested that five isoforms of CD40 exist with two predominant isoforms expressed in humans: signal-transducible CD40 type I and a C-terminal truncated, non-signal-transducible CD40 type II. We hypothesized that differential expression of CD40 isoform type I and type II in neurons may modulate neuron differentiation. Results show that adult wild-type, and CD40"-"/"- deficient mice predominantly express CD40 type I and II isoforms. Whereas adult wild-type mice express ...

2008-05-02

203

Fluidic shut-down system for a nuclear reactor

... v. 15(10) p. 445-449. automation control equipment fluid flow fluidic control

204

Control of triacylglycerol biosynthesis in plants

... fluid poison control fluidic control devices reactors scram scram rods control

205

A Control System for Traffic Light Based on GPRS

Title list.

1992-01-29

206

Transcriptome analysis reveals salt-stress-regulated biological processes and key pathways in roots of cotton (Gossypium hirsutum L.).

Not Available

2011-08-01

207

Residence time probability analysis of sulfur concentrations at Grand Canyon National Park

High salinity is one of the main factors limiting cotton growth and productivity. The genes that regulate salt stress in TM-1 upland cotton were monitored using microarray and real-time PCR (RT-PCR) with samples taken from roots. Microarray analysis showed that 1503 probe sets were up-regulated and 1490 probe sets were down-regulated in plants exposed for 3h to 100mM NaCl, and RT-PCR analysis validated 42 relevant/related genes. The distribution of enriched gene ontology terms showed such important processes as the response to water stress and pathways of hormone metabolism and signal transduction were induced by the NaCl treatment. Some key regulatory gene families involved in abiotic and biotic sources of stress such as WRKY, ERF, and JAZ were differentially expressed. Our transcriptome analysis might provide some useful insights into salt-mediated signal transduction pathways in cotton and offer a number of candidate genes as potential ...

2011-04-30

208

Land And Water Use Characteristics And Human Health Input Parameters For Use In Environmental Dosimetry And Risk Assessments At The Savannah River Site

A statistical method is developed to determine the locations of major pollutant sources affecting a distant downwind receptor, provided that air trajectories can be estimated. Probability density functions are estimated which indicate the overall residence time of air parcels over a given geographic region as they travel toward a receptor and residence time for the case of high pollutant concentrations at the receptor. These functions are used to estimate a conditional probability function which indicates the potential for a source region to contribute to high air pollution concentrations. Finally, a source contribution function is formulated to indicate the relative contribution of different source regions to high concentrations at the receptor. The method is tested using data collected at Grand Canyon National Park in 1980. The dominant pathway for air masses arriving at Grand Canyon during this period was southern California. A lesser ...

1985-01-01

209

Effects of Acetate Competition, pH and Soil Structure on the Rates and Pathways of Methane Formation in Tropical Rain Forest Soils

Operations at the Savannah River Site (SRS) result in releases of small amounts of radioactive materials to the atmosphere and to the Savannah River. For regulatory compliance purposes, potential offsite radiological doses are estimated annually using computer models that follow U.S. Nuclear Regulatory Commission (NRC) Regulatory Guides. Within the regulatory guides, default values are provided for many of the dose model parameters but the use of site-specific values by the applicant is encouraged. A detailed survey of land and water use parameters was conducted in 1991 and is being updated here. These parameters include local characteristics of meat, milk and vegetable production; river recreational activities; and meat, milk and vegetable consumption rates as well as other human usage parameters required in the SRS dosimetry models. In addition, the preferred elemental bioaccumulation factors and transfer factors to be used in human health exposure calculations at SRS are documented. ...

210

Translocation of labelled sucrose: A student exercise

The C isotopic composition of CH4 emissions are strongly influenced by the pathway of CH4 formation. Contrary to data from other freshwater systems, soil gas and surface flux measurements made in the tropical rain forests of Puerto Rico strongly suggest that CH4 produced in these environments was derived from CO2 reduction, rather than from acetate consumption. This study explored the effects of bacterial competition for acetate, pH, and soil structure on the pathways of CH4 formation in tropical rain forest soils. Our goal was to test two principal hypotheses: (1) ferric iron-reducing bacteria out-competed methanogens for acetate, resulting in greater CO2 reduction rather than aceticlastic methanogenesis, and (2) the low pH of tropical rain forest soils favors CO2 reduction rather than aceticlastic methanogenesis. In addition, this study also investigated the effect of destroying soil aggregate structure on the pathways ...

2004-12-01

211

Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease

Photosynthetic carbohydrates from the leaves are exported through the phloem to growing tips, roots, flowers and fruits. If sucrose labelled with {sup 14}C is applied to the leaves of bean plants, the pathway for sugar movement may be readily observed by autoradiography. Students apply the labelled sucrose during class time and return the next day to press their plants. During the next class, the pressed and dried plants are placed against X-ray film and left in the dark for four weeks. the film is then developed, examined for presence of label and compared to the pressed plants. Source to sink movement is clearly illustrated and information about the mechanism of phloem transport and loading is gained through experimental treatments, which include blocking the phloem pathway and inhibiting energy production.

1990-05-01

212

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia. Recently, many studies have implicated the role of inflammatory response, especially neuroinflammatory response in the development and progression of AD. However, the underlying mechanism of how inflammatory response induces AD is unknown. Kynurenine pathway is a major route of the amino acid tryptophan catabolism, resulting in the production of nicotine adenine dinucleotide and other neuroactive intermediates: quinolinic acid (QA) and kynurenic acid (KA). QA exerts different toxic effects, including over-activation of N-methyl-d-aspartate (NMDA) receptor and excitotoxicity, synaptic dysfunction and neuronal death. On the other hand, KA is identified as the only...

2011-01-01

213

SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway

British Library Electronic Table of Contents (United Kingdom)

Background and purpose: The aims of this study were to investigate the anti-cancer activity of SZ-685C, an anthracycline analogue isolated from marine-derived mangrove endophytic fungi, and to explore the molecular mechanisms underlying such activity. Experimental approach: The effect of SZ-685C on the viability of cancer cell lines was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. SZ-685C-induced apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay and analysis of caspase activation. The effect of SZ-685C on the Akt/FOXO pathway was studied using Western blotting analysis, and the in vivo anti-tumour efficacy was examined in ...

2010-01-01

214

Pore structure of volcanic clasts: Measurements of permeability and electrical conductivity

British Library Electronic Table of Contents (United Kingdom)

The pore structure of volcanic clasts is examined using measurements of porosity, permeability, and electrical properties. Permeability varies by several orders of magnitude among volcanic clasts and does not depend solely upon porosity. Electrical property measurements of saturated volcanic samples illustrate the influence of pathway tortuosity and pore shape on permeability. For equivalent eruption conditions, silicic samples show higher tortuosities, smaller vesicle sizes, and lower permeabilities than mafic samples. These differences are largely due to variations in vesiculation and crystallization history. Differences between explosive and effusive samples reflect the relative ability of bubbles to form and maintain connected pathways during bubble expansion and collapse. Isotropic sa...

2009-01-01

215

Pathways for implementing REDD+. Experiences from carbon markets and communities

Molecular biology of the renin-angiotensin system

This issue of Carbon Market Perspectives on 'Pathways for implementing REDD+: Experience from carbon markets and communities' discusses the role of carbon markets in scaling up investments for REDD+ in developing countries. Nine articles authored by experienced negotiators on REDD+, carbon market actors, project developers and other leading experts share experiences and make suggestions on the key elements of a future international REDD+ regime: Architecture and underlying principles, measuring, reporting and verification (MRV), private-sector involvement, the rights of indigenous people and local communities, biodiversity conservation and environmental integrity. The articles are grouped under three main topics: the lessons of existing REDD+ projects; the future REDD+ regime and the role of carbon markets; and experiences and ideas about the involvement of indigenous people and local communities. (LN)

2011-07-01

216

Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.

1988-10-01

217

British Library Electronic Table of Contents (United Kingdom)

Current studies in plants suggest that the content of the coenzyme NAD is variable and potentially important in determining cell fate. In cases that implicate NAD consumption, re-synthesis must occur to maintain dinucleotide pools. Despite information on the pathways involved in NAD synthesis in plants, the existence of a mitochondrial nicotinamide mononucleotide adenylyltransferase (NMNAT) activity which catalyses NAD synthesis from nicotinamide mononucleotide (NMN) and ATP has not been reported. To verify the latter assumed pathway, experiments with purified and bioenergetically active mitochondria prepared from tubers of Jerusalem artichoke (Helianthus tuberosus L.) were performed. To determine whether NAD biosynthesis might occur, NMN was added to Jerusalem artichoke mitochondria (JAM)...

2011-01-01

218

Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

2011-01-01

219

Experimental bovine trypanosomiasis. Changes in serum immunoglobulins, complement and complement components in infected animals.

Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli

In three calves experimentally infected with Trypanosoma congolense the amounts of IgG1 and IgG2 were little changed and similar to those of normal animals. IgM increased in amount early in the infection and the amount of the increase appeared related to the parasite burden. The amounts of IgA and IgE were both much decreased and this also appeared related to the numbers of parasites in the blood. There was a decrease in the amounts of total haemolytic complement and complement components C1, C1q and C3 in the infected calves. Furthermore the amounts of properdin fluctuated with the cyclical changes in numbers of T. congolense parasites in the individual calves. No significant change in the amount of C8 was observed. It is considered that activation of both the alternative and the classical complement pathways occurs in trypanosome infected animals but that neither pathway goes to its terminal stages.

1978-11-01

220

British Library Electronic Table of Contents (United Kingdom)

2-methylpropan-1-ol (isobutanol) is a leading candidate biofuel for the replacement or supplementation of current fossil fuels. Recent work has demonstrated glucose to isobutanol conversion through a modified amino acid pathway in a recombinant organism. Although anaerobic conditions are required for an economically competitive process, only aerobic isobutanol production has been feasible due to an imbalance in cofactor utilization. Two of the pathway enzymes, ketol-acid reductoisomerase and alcohol dehydrogenase, require nicotinamide dinucleotide phosphate (NADPH); glycolysis, however, produces only nicotinamide dinucleotide (NADH). Here, we compare two solutions to this imbalance problem: (1) over-expression of pyridine nucleotide transhydrogenase PntAB and (2) construction of an NADH-de...

2011-01-01

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221

Chronic sympathetic activation promotes downregulation of ?-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction

British Library Electronic Table of Contents (United Kingdom)

It is uncertain if downregulation of ?-adrenoceptor signaling pathway is promoted by an enhanced adrenergic tone at an early stage of cardiac disease, or it develops secondary to detrimental local myocardial changes in advanced heart failure. We examined the integrity of ?-adrenoceptor signaling pathway upon chronic infusion of isoproterenol, a ?-adrenoceptor agonist, at a dose producing no structural left ventricular (LV) remodeling and systolic dysfunction. Subcutaneous isoproterenol infusion (400??g?kg?1?h?1 over 16?days) to guinea pigs using osmotic minipumps produced no change in cardiac weights, LV internal dimensions, myocyte cross-sectional area, extent of interstitial fibrosis, and basal contractile function. Isolated, perfused heart preparations from isoproterenol-treated guinea ...

2011-01-01

222

A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium

British Library Electronic Table of Contents (United Kingdom)

Summary Background Sorafenib is an oral multikinase inhibitor that blocks cell proliferation via the ERK pathway and angiogenesis via the VEGF pathway. This phase II trial was conducted to determine the efficacy and tolerability of sorafenib for the treatment of patients with metastatic urothelial cancer (UC) who had not had prior chemotherapy for advanced disease. Patients and Methods Seventeen chemo-na?ve UC patients with adequate performance status and organ function were treated with sorafenib 400?mg twice daily on a continuous basis until progression or unacceptable toxicity. The primary endpoint was objective tumor response rate as measured by RECIST criteria. Secondary endpoints included rate of prolonged stable disease (>3?months), time to progression, median and 1?yr survival and ...

2011-01-01

223

A computer program for rapid calculation of internal committed effective dose through inhalation and ingestion pathways under radiological emergency

6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2

Objective: To establish a computer program for rapid calculation of internal committed effective close through inhalation and ingestion pathways under radiological emergency. Methods: Visual Basic 6.0 is used to compile the generic procedures of internal committed effective dose by inhalation and ingestion in IAEA-TECDOC-1162, Generic Procedures for Assessment and Response during a Radiological Emergency. Results: The assessment methodology of internal committed effective dose by inhalation and ingestion under radiological emergency in the report IAEA-TECDOC-1162 can be coded into a computer program. Conclusions: This research provides a rapid method of assessment for internal committed effective dose by inhalation and ingestion under radiological emergency, and it may provide needed dosimetry data for treatment under emergency response. (authors)

2008-08-01

224

British Library Electronic Table of Contents (United Kingdom)

A range of 6-substituted imidazo[1,2-a]pyridines were synthesized using a multicomponent coupling reaction. Most of these compounds were found to exhibit excellent activity against the colon cancer cell lines HT-29 and Caco-2, whilst not showing significant toxicity against white blood cells. Our studies have shown that the proteolytic phase of apoptosis was initiated 2 h after treatment with these imidazo-[1,2-a]pyridines. The data suggests that the imidazo[1,2-a]pyridine-induced cell death in HT-29 and Caco-2 cells is mediated via pathway(s) that include the release of cytochrome c from the mitochondria to the cytosol and the activation of caspase 3 and caspase 8.

2011-01-01

225

Seismic Response Control of Adjacent Structures by Semi-Active Fuzzy Control of Magneto-Rheological Damper

Regulatory Control of Radioactive Waste Management Overview of 15 NEA Member Countries

Full Text Available

2009-06-01

226

Randomized Algorithms for Analysis and Control of Uncertain Systems

Regulatory Control of Radioactive Waste Management

2004-01-01

227

Power fluidics for ventilation control

Randomized Algorithms for Analysis and Control of Uncertain Systems

2005-01-01

228

Newly developed control and stop valves

... amplification exhaust systems fluidic control devices gloveboxes pressure

1984-11-28

229

Multi-Harmonic RF Control System for J-PARC RCS

... bwr type reactors closures fluidic control devices operation performance pwr

230

Input-output stability for accelerometer control systems

Multi-Harmonic RF Control System for J-PARC RCS

2003-01-01

231

Fluidic programmer for nuclear engine application

It is shown that, although accelerometer control systems are not well-posed in the sense of Salamon,

1991-01-01

232

Entomopathogenic Nematodes in Biological Control

... fluidic control devices performance reactor control systems space propulsion

233

Enhanced Model Predictive Control:Dual Control Approach and State Estimation Issues

Commercial Production and Development, in Entomopathogenic Nematodes in Biological Control

234

Control of Phosphorus Transient Enhanced Diffusion using Co-implantation

Full Text Available

235

Individual Radiation Protection Monitoring in the Marshall Islands: Rongelap Atoll (2002-2004)

Control of Phosphorus Transient Enhanced Diffusion using Co-implantation

2006-01-01

236

FY2007 Oak Ridge National Laboratory Annual Progress Report for the Power Electronics and Electric Machinery Program

The United States Department of Energy (U.S. DOE) has recently implemented a series of strategic initiatives to address long-term radiological surveillance needs at former U.S. nuclear test sites in the Marshall Islands. The plan is to engage local atoll communities in developing shared responsibilities for implementing radiation protection monitoring programs for resettled and resettling populations in the northern Marshall Islands. Using the pooled resources of the U.S. DOE and local atoll governments, individual radiological surveillance programs have been developed in whole body counting and plutonium urinalysis in order to accurately assess radiation doses resulting from the ingestion and uptake of fallout radionuclides contained in locally grown foods. Permanent whole body counting facilities have been established at three separate locations in the Marshall Islands including Rongelap Atoll (Figure 1). These facilities are operated and maintained by Marshallese technicians with ...

2006-01-17

237

Cooperative control for multiple manipulators using an extended passive velocity field control; Passive velocity field control wo mochiita fukuwan kyocho seigyo

The U.S. Department of Energy (DOE) and the U.S. Council for Automotive Research (composed of automakers Ford, General Motors, and Chrysler) announced in January 2002 a new cooperative research effort. Known as 'FreedomCAR' (derived from 'Freedom' and 'Cooperative Automotive Research'), it represents DOE's commitment to developing public/private partnerships to fund high-risk, high-payoff research into advanced automotive technologies. Efficient fuel cell technology, which uses hydrogen to power automobiles without air pollution, is a very promising pathway to achieving the ultimate vision. The new partnership replaces and builds upon the Partnership for a New Generation of Vehicles initiative that ran from 1993 through 2001. The Advanced Power Electronics and Electric Machines (APEEM) subprogram within the FreedomCAR and Vehicle Technologies Program provides support and guidance for many cutting-edge ...

2007-10-01

238

c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis

In this paper, we propose a new cooperative control method for multiple robotic systems that eliminates several issues in the discentralized control method. The proposed control method is constructed by extending a Passive Velocity Field Control (PVFC). It is easy to guarantee the stability in control, because the PVFC can keep the passivity of the controlled system. In this study, the cooperative control method is proposed and then it`s stability is proven. Moreover, it is extended so as to control an internal force and to control a virtual time. Finally, the efficiency of the proposed cooperative control method are examined by computer simulations for cooperation tasks with two manipulators. 11 refs., 7 figs., 1 tab.

1997-12-20

239

Variations in Kinetic Properties of Ribulose-1,5-bisphosphate Carboxylases among Plants

c-Jun N-terminal kinase 2 (JNK2) isoforms are transcribed from the jnk2 gene and are highly homologous with jnk1 and jnk3 transcriptional products....Full Text Available

2011-01-01

240

Urban Atmospheric Science

Studies of ribulose-1,5-bisphosphate (RuBP) carboxylase from taxonomically diverse plants show that the enzyme from C₃ and crassulacean acid metabolism pathway species exhibits lower K_m(CO₂)...Full Text Available

1981-06-01

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241

Up-Regulation of the RhoA/Rho-Kinase Signaling Pathway in Corpus Cavernosum from Endothelial Nitric-Oxide Synthase (NOS), but Not Neuronal NOS, Null Mice

DescriptionThis new research programme activity on Urban Atmospheric Science will deliver aspects of the NERC strategy: Next Generation Science for Planet Earth. It has been developed as part of the Environment, Pollution & Human Health theme. Research in the Environment, Pollution & Human Health theme is directed at elucidating key environmental processes that form part of a causal pathway between an environmental hazard and disease outcome, and providing a predictive capability of the risk to human heal [continued...

2012-01-01

242

Transcriptome sequencing and annotation of the microalgae Dunaliella tertiolecta: Pathway description and gene discovery for production of next-generation biofuels

We tested the hypothesis that the basal release of nitric oxide (NO) from endothelial cells modulates contractile activity in the corpus cavernosum (CC) via inhibition of the RhoA/Rho-kinase signaling...Full Text Available

2010-04-01

243

The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway.

BackgroundBiodiesel or ethanol derived from lipids or starch produced by microalgae may overcome many of the sustainability challenges previously ascribed to petroleum-based fuels and first generation plant-based biofuels. The paucity of microalgae genome sequences, however, limits gene-based biofuel feedstock optimization studies. Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production.ResultsNext generation DNA pyrosequencing technology applied to D. tertiolecta transcripts produced 1,363,336 high quality reads with an average length of 400 bases. Following quality and size trimming, ~ 45% of the high quality reads were assembled into 33,307 isotigs with a 31-fold coverage and 376,482 singletons. Assembled sequences and singletons were subjected to BLAST similarity searches and annotated with Gene Ontology (GO) and ...

2011-03-14

244

The Putative Natural Killer Decoy Early Gene m04 (gp34) of Murine Cytomegalovirus Encodes an Antigenic Peptide Recognized by Protective Antiviral CD8 T Cells

The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia...Full Text Available

1993-06-01

245

Strategic pathways for energy in Brazil; Os caminhos da eficiencia energetica no Brasil

Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation...Full Text Available

2000-02-01

246

Stable Isotope Labeling, in Vivo, of d- and l-Tryptophan Pools in Lemna gibba and the Low Incorporation of Label into Indole-3-Acetic Acid ¹

The aim of this work is to suggest steps and policies to increase the introduction of cost-effective energy in conservation measures in Brazil. This report first addresses the motivations for a policy of energy efficiency and summarizes experiences in Brazil. It then considers the roles and perspectives of the diverse agents and review the instruments of policy. It concludes with an overview of strategic needs and lines of action.

1995-01-01

247

Silver nanoparticles inhibit VEGF-and IL-1?-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells

We present evidence that the role of tryptophan and other potential intermediates in the pathways that could lead to indole derivatives needs to be reexamined. Two lines of Lemna gibba...Full Text Available

1991-04-01

248

Prostaglandin E₂ Signals Through PTGER2 to Regulate Sclerostin Expression

The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1β)-induced vascular permeability, and...Full Text Available

249

The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass. Similarly, mutations...Full Text Available

250

Plant Sulphur Nutrition

Pathways to equity in mathematics education: how life experiences impact researcher positionality

DescriptionThe recent sequencing of the complete genomes of several streptomycete species revealed the presence of a large number of cryptic' secondary metabolic gene clusters, and led to the realisation that these organisms have the ability to produce many more natural products than had previously been recognised. One of the aims of our work is to identify the physiological signals and regulatory mechanisms responsible for the activation of these 'cryptic' pathways, thus unleashing the full biosynthetic p [continued...

2010-01-31

251

British Library Electronic Table of Contents (United Kingdom)

This study examined the life histories of a group of emerging scholars in the field of mathematics education who identify themselves as having a particular interest in and concern for issues of equity and diversity. Experiences of being the "other," "bearing witness" to "othering experiences," and "orienting experiences" in relation to issues of equity proved to be prominent themes in participants' life histories. These experiences were then linked to the positionality that these scholars now have in relation to their research in mathematics education.

2011-01-01

252

Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development

PI3K/Akt and mTOR/p70S6K Pathways Mediate Neuroprotectin D1-Induced Retinal Pigment Epithelial Cell Survival during Oxidative Stress-Induced Apoptosis

The clinicopathologic features of 472 ovarian epithelial clear cell neoplasms (4 adenofibromas [AFs], 41 atypical proliferative [borderline] tumors [APTs], and 427 carcinomas [CAs]) were studied in...Full Text Available

253

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

The initiation and progression of several forms of retinal degenerations involve excessive, repetitive, and/or sustained oxidative stress that, in turn, mediate photoreceptor cell damage and...Full Text Available

2010-06-01

254

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.

Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation...Full Text Available

2010-11-23

255

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation...Full Text Available

1996-12-02

256

Insect-Induced Conifer Defense. White Pine Weevil and Methyl Jasmonate Induce Traumatic Resinosis, de Novo Formed Volatile Emissions, and Accumulation of Terpenoid Synthase and Putative Octadecanoid Pathway Transcripts in Sitka Spruce1[w

Despite intensive efforts, the intracellular signaling pathways that mediate apoptosis remain unclear. The human B lymphoma cell line, B104, possesses characteristics that make it an attractive model...Full Text Available

1996-11-26

257

Ingestion Pathway Consequences of a Major Release from SRTC

Stem-boring insects and methyl jasmonate (MeJA) are thought to induce similar complex chemical and anatomical defenses in conifers. To compare insect- and MeJA-induced terpenoid responses, we analyzed...Full Text Available

2005-01-01

258

Homocysteine effects classical pathway of GPCR down regulation: G?_q/11, G?_12/13, G_i/o

The food ingestion consequences due to radioactive particulates of an accidental release, scenario 1-RD-3, are evaluated for Savannah River Technology Center. The sizes of land areas requiring the protective action of food interdiction are calculated. The consequences of the particulate portion of the release are evaluated with the HOTSPOT model and an EXCEL spreadsheet for particulates.

1999-06-08

259

Highly Pathogenic H5N1 Avian Influenza: Entry Pathways into North America via Bird Migration

G protein-coupled receptors (GPCRs) are known to modulate intracellular effectors involved in cardiac function. We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed...Full Text Available

2009-01-01

260

Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E₂/EP2 receptor pathway

Given the possibility of highly pathogenic H5N1 avian influenza arriving in North America and monitoring programs that have been established to detect and track it, we review intercontinental movements...Full Text Available

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261

Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.

Growth differentiation factor-9 (GDF-9), an oocyte-secreted member of the transforming growth factor β superfamily, progesterone receptor, cyclooxygenase 2 (Cox2; Ptgs2), and the EP2 prostaglandin...Full Text Available

2000-08-29

262

Folate fortification of rice by metabolic engineering

African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for evidence of selective sweeps. The scan of the EST sequences ...

2011-05-18

263

British Library Electronic Table of Contents (United Kingdom)

Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement.

2007-01-01

264

Essential Role for Cellular Phosphoglucomutase in Virulence of Type 3 Streptococcus pneumoniae

Elucidating novel pathways and regulation of nitrogen assimilation in alpha proteobacteria exemplified by the soil organism Paracoccus denitrificans

Synthesis of the Streptococcus pneumoniae type 3 capsule requires the pathway glucose-6-phosphate (Glc-6-P) → Glc-1-P → UDP-Glc → UDP-glucuronic acid (UDP-GlcUA)...Full Text Available

2001-04-01

265

Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts

DescriptionThe importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognised, in particularly because of the 'blooms' formed in nitrate and phosphate polluted water and their possible roles as carbon dioxide sinks. By contrast, the utilisation of nitrate by heterotrophic bacteria has historically received less attention. Up until now, the primary role of heterotrophic bacteria has classically been considered to be the decomposition [continued...

2010-01-31

266

Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites.

Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF. Studies performed during the last decade have shown many details of how CDK1 is regulated...Full Text Available

267

ATP-gated P2X₃ receptors constitute a positive autocrine signal for insulin release in the human pancreatic ? cell

Surveys of the antigenic properties of a wide range of variants of the H3N2 (Hong Kong) influenza virus subtype have revealed complex patterns of variants cocirculating during each of the main epidemic...Full Text Available

1983-10-01

268

ARSENIC TRIOXIDE INDUCES A BECLIN-1 INDEPENDENT AUTOPHAGIC PATHWAY VIA MODULATION OF SNON/SKIL EXPRESSION IN OVARIAN CARCINOMA CELLS

Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of an ATP signaling pathway that enhances...Full Text Available

2010-04-06

269

A Combinatorial Interplay Among the 1-Aminocyclopropane-1-Carboxylate Isoforms Regulates Ethylene Biosynthesis in Arabidopsis thaliana

Arsenic trioxide (As₂O₃), used to treat promyelocytic leukemia, triggers cell death via unknown mechanisms. To further our understanding of As₂O₃-induced...Full Text Available

2010-12-01

270

An outline of the fuelling machine electrical instrumentation and controls

Ethylene (C₂H₄) is a unique plant-signaling molecule that regulates numerous developmental processes. The key enzyme in the two-step biosynthetic pathway of ethylene is 1-aminocyclopropane-1-carboxylate...Full Text Available

2009-11-01

271

Robust computationally efficient control of cooperative closed-chain manipulators with uncertain dynamics

An outline of the instrumentation and control systems associated with fuelling machines is given. The control systems such as hydraulic system, oil hydraulic system, electric control system and the remote control systems have been discussed in detail. The difference between RAPP and MAPP fuel handling control systems has been explained. A computer based system for the Narora fuel handling control system is also discussed. (S.K.K.).

272

British Library Electronic Table of Contents (United Kingdom)

This article presents a decentralized control scheme for the complex problem of simultaneous position and internal force control in cooperative multiple manipulator systems. The proposed controller is composed of a sliding mode control term and a force robustifying term to simultaneously control the payloads position/orientation as well as the internal forces induced in the system. This is accomplished independently of the manipulators dynamics. Unlike most controllers that do not require prior knowledge of the manipulators dynamics, the suggested controller does not use fuzzy logic inferencing and is computationally inexpensive. Using a Lyapunov stability approach, the controller is proven to be robust in the face of varying systems dynamics. The payloads position/orientation and the inte...

2007-01-01

273

Control rod drives

Study on body composition for the control of efficacy of full parenteral nutrition

Purpose: To secure the reactor operation safety by the provision of a fluid pressure detecting section for control rod driving fluid and a control rod interlock at the midway of the flow pass for supplying driving fluid to the control rod drives. Constitution: Between a driving line and a direction control valve are provided a pressure detecting portion, an alarm generating device, and a control rod inhibition interlock. The driving fluid from a driving fluid source is discharged by way of a pump and a manual valve into the reactor in which the control rods and reactor fuels are contained. In addition, when the direction control valve is switched and the control rods are inserted and extracted by the control rod drives, the pressure in the driving line is always detected by the pressure detection ...

274

Robust Control for a Ultra-Precision Stage System

Short note.

275

Reactor control system using knowledge information

Full Text Available

2006-09-01

276

New Loss Minimization Vector Control for Induction Motors

No abstract prepared

1998-01-01

277

Motion Synchronization of Control for Multi Electro-Hydraulic Actuators

Full Text Available

2011-06-01

278

Model predictive control of a crude oil distillation column

Full Text Available

2011-09-01

279

Microsoft Word - lbnl-58220r.doc

Full Text Available

280

Wastenet

operating at the maximal setting of speed control dials used to control their ...evaluates their energy performance when the speed control dial used ...FFUs when the speed control dial used for adjusting fan wheel speeds in each FFU was

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281

Elementary Decoupling control of composition in binary distillation columns

Electronic Health Records An Audit and Internal Control Guide

Full Text Available

282

Drop Time Evaluation for SMART Control Rod Assembly

Electronic Health Records

2008-01-01

283

Cooperative Computer Vision for Flexible Advanced Robot Controllers

Full Text Available

2011-04-01

284

An extensible Java user interface framework for controlling distributed systems

No Abstract Available

1993-01-01

285

Advanced Distillation Curve Measurement with a Model Predictive Temperature Controller

No Abstract Available

2003-01-01

286

A hardware design of Rate control algorithm for H.264

Not Available

2006-09-01

287

A Design of Over-driving Controller to Reduce Motion Blur

Full Text Available

2010-01-01

288

Full Text Available

2010-04-01

289

Flow Control

COMPUTERIZED CONTROL OF BLAST FURNACE COKE ...

... 65th AGARD Fluid Dynamics Symposium, Madrid, Spain, October ... of research programs on flow control ... separation, and delta wing flows formed the ...

1991-04-30

290

The controllability analysis of the purification system for heavy water reactors

... Title : COMPUTERIZED CONTROL OF BLAST FURNACE COKE-WEIGHING OPERATIONS USING NEUTRON MOISUTRE GAUGES. ...

1974-09-01

291

The LLNL computer control system

The heavy water reactor such as Wolsung No.1 and No.2 has a purification system to purify the reactor coolant. The control system regulates the coolant temperature to protect the ion exchanger. After the fuel exchanges of operating plant, the increase of the coolant pressure makes the purification temperature control difficult. In this paper, the controllability of the control dynamics of the purification system was analysed and the optimal parameters were proposed. To reduce the effects of the flow disturbance, the feedforward control structure was proposed and analysed.

2001-10-01

292

Flow control with variable inflow as an alternative to conventional nozzle group control - automatic control of large capacity steam turbines

Lawrence Livermore National Laboratory (LLNL) has implemented a computer control system for operation of an FN tandem accelerator. The control software utilized is the Thaumaturgic Automated Control Logic (TACL) written by the Continuous Electron Beam Accelerator Facility and co-developed with LLNL. Details of the design philosophy, hardware configuration, control software, and special control algorithms will be presented. 2 refs., 4 figs.

1991-10-03

293

Estimates of Amplitudes of Transient Regimes in Quasi-Controllable Discrete Systems

In the case of large capacity steam turbines the conventional nozzle group control is, for mechanical and thermodynamic reasons, diminishing more and more in importance in favour of variable pressure control. A design for constant-pressure operation as an alternative to nozzle group control is described; this demonstrates a series of important advantages compared with the latter. (orig.).

294

Controllable Subspaces of Open Quantum Dynamical Systems

Families of regimes for discrete control systems are studied possessing a special quasi-controllability property that is similar to the Kalman controllability property. A new approach is proposed to estimate the amplitudes of transient regimes in quasi-controllable systems. Its essence is in obtaining of constructive a priori bounds for degree of overshooting in terms of the quasi-controllability measure. The results are applicable for analysis of transients, classical absolute stability problem and, especially, for stability problem for desynchronized (asynchronous, switching) systems.

2009-01-01

295

Radioactive contamination of fish, shellfish, and waterfowl exposed to Hanford effluents: Annual summaries, 1945--1972. Hanford Environmental Dose Reconstruction Project

This paper discusses the concept of controllable subspace for open quantum dynamical systems. It is constructively demonstrated that combining structural features of decoherence-free subspaces with the ability to perform open-loop coherent control on open quantum systems will allow decoherence-free subspaces to be controllable. This is in contrast to the observation that open quantum dynamical systems are not open-loop controllable. To a certain extent, this paper gives an alternative control theoretical interpretation on why decoherence-free subspaces can be useful for quantum computation.

2008-01-15

296

Radioactive contamination of fish, shellfish, and waterfowl exposed to Hanford effluents: Annual summaries, 1945--1972

The objective of the Hanford Environmental Dose Reconstruction Project (HEDR) is to estimate the potential radiation doses received by people living within the sphere of influence of the Hanford Site. A potential critical pathway for human radiation exposure is through the consumption of waterfowl that frequent onsite waste-water ponds or through eating of fish, shellfish, and waterfowl that reside in/on the Columbia River and its tributaries downstream of the reactors. This document summarizes information on fish, shellfish, and waterfowl radiation contamination for samples collected by Hanford monitoring personnel and offsite agencies for the period 1945 to 1972. Specific information includes the types of organisms sampled, the kinds of tissues and organs analyzed, the sampling locations, and the radionuclides reported. Some tissue concentrations are also included. We anticipate that these yearly summaries will be helpful to individuals and organizations ...

1992-07-01

297

Radioactive contamination of fish, shellfish, and waterfowl exposed to Hanford effluents: Annual summaries, 1945--1972

The objective of the Hanford Environmental Dose Reconstruction Project (HEDR) is to estimate the potential radiation doses received by people living within the sphere of influence of the Hanford Site. A potential critical pathway for human radiation exposure is through the consumption of waterfowl that frequent onsite waste-water ponds or through eating of fish, shellfish, and waterfowl that reside in/on the Columbia River and its tributaries downstream of the reactors. This document summarizes information on fish, shellfish, and waterfowl radiation contamination for samples collected by Hanford monitoring personnel and offsite agencies for the period 1945 to 1972. Specific information includes the types of organisms sampled, the kinds of tissues and organs analyzed, the sampling locations, and the radionuclides reported. Some tissue concentrations are also included. We anticipate that these yearly summaries will be helpful to individuals and organizations ...

1992-07-01

298

Putative intermediates in the nerve cell differentiation pathway in hydra have properties of multipotent stem cells

The objective of the Hanford Environmental Dose Reconstruction Project (HEDR) is to estimate the potential radiation doses received by people living within the sphere of influence of the Hanford Site. A potential critical pathway for human radiation exposure is through the consumption of waterfowl that frequent onsite waste-water ponds or through eating of fish, shellfish, and waterfowl that reside in/on the Columbia River and its tributaries downstream of the reactors. This document summarizes information on fish, shellfish, and waterfowl radiation contamination for samples collected by Hanford monitoring personnel and offsite agencies for the period 1945 to 1972. Specific information includes the types of organisms sampled, the kinds of tissues and organs analyzed, the sampling locations, and the radionuclides reported. Some tissue concentrations are also included. We anticipate that these yearly summaries will be helpful to individuals and organizations ...

299

OSCAAR calculations for the Iput dose reconstruction scenario of BIOMASS theme 2

We have investigated the properties of nerve cell precursors in hydra by analyzing the differentiation and proliferation capacity of interstitial cells in the peduncle of Hydra oligactis, which is a region of active nerve cell differentiation. Our results indicate that about 50% of the interstitial cells in the peduncle can grow rapidly and also give rise to nematocyte precursors when transplanted into a gastric environment. If these cells were committed nerve cell precursors, one would not expect them to differentiate into nematocytes nor to proliferate apparently without limit. Therefore we conclude that cycling interstitial cells in peduncles are not intermediates in the nerve cell differentiation pathway but are stem cells. The remaining interstitial cells in the peduncle are in G1 and have the properties of committed nerve cell precursors. Thus, the interstitial cell population in the peduncle contains both stem cells and noncycling nerve precursors. The ...

1990-12-01

300

Multi-unit Inertial Fusion Energy (IFE) plants producing hydrogen fuel

This report presents the results obtained from the application of the accident consequence assessment code, called OSCAAR, developed in Japan Atomic Energy Research Institute to the Iput dose reconstruction scenario of BIOMASS Theme 2 organized by International Atomic Energy Agency. The Iput Scenario deals with {sup 137}Cs contamination of the catchment basin and agricultural area in the Bryansk Region of Russia, which was heavily contaminated after the Chernobyl accident. This exercise was used to test the chronic exposure pathway models in OSCAAR with actual measurements and to identify the most important sources of uncertainly with respect to each part of the assessment. The OSCAAR chronic exposure pathway models almost successfully reconstructed the whole 10-year time course of {sup 137}Cs activity concentrations in most requested types of agricultural products and natural foodstuffs. Modeling of {sup 137}Cs downward migration in soils is, ...

2001-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Inverse spinel materials. A new class of high voltage cathode materials for Li-ion batteries

A quantitative energy pathway comparison is made between a modern oil refinery and genetic fusion hydrogen plant supporting hybrid-electric cars powered by gasoline and hydrogen-optimized internal combustion engines, respectively, both meeting President Clinton's goal for advanced car goal of 80 mpg gasoline equivalent. The comparison shows that a fusion electric plant producing hydrogen by water electrolysis at 80% efficiency must have an electric capacity of 10 GWe to support as many hydrogen-powered hybrid cars as one modern 200,000 bbl/day-capacity oil refinery could support in gasoline-powered hybrid cars. A 10 GWe fusion electric plant capital cost is limited to 12.5 B$ to produce electricity at 2.3 cents/kWehr, and hydrogen production by electrolysis at 8 $/GJ, for equal consumer fuel cost per passenger mile as in the oil-gasoline-hybrid pathway.

1994-06-20

302

Human tissue factor pathway inhibitor (TFPI) gene: Complete genomic structure and localization on the genetic map of chromosome 2q

The influence of Cr on the structure and electrochemical properties of LiCoVO{sub 4} was studied using X-Ray diffraction, scanning electron microscopy, Raman Spectroscopy and cycle tests. Doping levels up to 10 mol% were achieved, which improved the electrochemical stability of the structure of LiCoVO{sub 4}, resulting in a significant increase in the initial charge and discharge capacity. The Raman spectroscopy data for the Cr-doped LiCoVO{sub 4} is similar as for LiCoVO{sub 4}. The replacement of a dopant for the Co-ion in the inverse spinel structure causes several Raman shifts. The X-ray diffraction patterns show no new phases and combined with the Raman spectroscopy data it is concluded that the Cr dopant will be located at the octahedral site (16d) where they create an electronic pathway that enhances the electronic conductivity. However, the capacity dropped significantly after prolonged cycling, which is due to the diffusion of V{sup 5+} ions from the ...

2003-07-01

303

Hexene catalytic cracking over 30% sapo-34 catalyst for propylene maximization: influence of reaction conditions and reaction pathway exploration

Tissue factor pathway inhibitor (TFPI), a protease inhibitor that circulates in association with plasma lipoproteins (VLDL, LDL and HDL), helps to regulate the extrinsic blood coagulation cascade. The authors have cloned a 125-kb genomic region containing the entire human TFPI gene on six overlapping cosmids and prepared a restriction map of this contig to clarify gene structure. More than half (45 kb) of the 85-kb gene is occupied with 5[prime] noncoding elements: coding begins at exon 3. A HindIII RFLP identified with one cosmid was genotyped in the CEPH panel of 559 reference families. Linkage analysis using markers on human chromosome 2 located the TFPI gene on 2q, 36 cM proximal to D2S43(pYNZ15) and 13 cM distal to the crystalline [gamma]-polypeptide locus CRYGP1(p5G1). 31 refs., 3 figs., 3 tabs.

1993-08-01

304

Scientific Electronic Library Online (English)

Abstract in english Higher olefins are produced as a by product in a number of refinery processes and are one of the potential raw materials to produce propylene. In the present study, FCC model feed compound was considered to explore the olefin cracking features and options to enhance propylene using 30% SAPO-34 zeolite as catalyst in a micro-reactor. The superior selectivity of propylene (73 wt%) and higher total olefin selectivity was obtained over 30% SAPO-34 catalyst than over Y or ZSM- (more) 5 zeolite catalysts. The thermodynamical constraints were found to be relatively less serious in the case of 1-hexene conversion. Most of the 1-hexene follows a direct cracking pathway to give two propylene molecules, due to weak acid sites and better diffusion opportunities. The higher temperature and short residence time could also suppress the hydrogen transfer reactions. From OPE (olefins performance envelop) the products were classified as primary, secondary, or ...

2009-12-01

305

Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation

British Library Electronic Table of Contents (United Kingdom)

Wnt signaling negatively regulates adipocyte differentiation, and ectopic expression of Wnt-1 in 3T3-L1 cells induces several downstream molecules of Wnt signaling, including Wnt-1 inducible signaling pathway protein (WISP)-2. In this study, we examined the role of WISP-2 in the process of adipocyte differentiation using an in vitro cell culture system. In the differentiation of 3T3-L1 cells, WISP-2 expression was observed in growing cells and declined thereafter. In the mitotic clonal expansion phase of adipocyte differentiation, WISP-2 expression was transiently down-regulated concurrently with up-regulation of CCAAT/enhancer-binding protein d expression. Treatment of 3T3-L1 cells in the differentiation medium with lithium, an activator of Wnt signaling, inhibited the differentiation pro...

2009-01-01

306

Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-kB pathways in mouse thymic epithelial cells

British Library Electronic Table of Contents (United Kingdom)

Thymic epithelial cells (TECs) constitute a major component of the thymic stroma which provides a microenvironment critical for developing thymocytes. We have previously demonstrated that doxycycline (Dox), a tetracycline derivative, enhances the proliferation of the mouse thymic epithelial cell line 1 (MTEC1) via MAPK/ERK signal pathway. Herein we provide evidence that Dox also has profound impact on the cytokine production by MTEC1. Specifically, the expression of IL-6 and GM-CSF, both at mRNA and protein levels, was found to be increased in a time- and dose-dependent manner with the addition of Dox. Western blotting analysis revealed that treatment with Dox-induced phosphorylation of the p65 subunit of NF-kB and ERK. Notably, Dox-induced up-regulation of IL-6 and GM-CSF was largely abol...

2011-01-01

307

Data Merging for Integrated Microarray and Proteomic Analysis

Cell volume regulation in hemoglobin CC and AA erythrocytes

The functioning of even a simple system is much more complicated than the sum of its genes, proteins and metabolites. A premise of systems biology is that molecular profiling will lead to the discovery and characterization of important disease pathways. However, as multiple levels of effector pathway regulation appear to be the norm rather than the exception, a significant challenge presented by high-throughput genomics and proteomics technologies is to extract the biological implications of complex data. Thus, integration of heterogeneous types of data generated from diverse global technology platforms represents the first challenge in developing the necessary foundational databases needed for predictive modeling of cell and tissue responses. Given the apparent difficulty in defining the correspondence between gene expression and protein abundance measured in several systems to date, how do we make sense of these data and design the next ...

2006-05-10

308

ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes

Swelling hemoglobin CC erythrocytes stimulates a ouabain-insensitive K flux that restores original cell volume. Studies were performed with the K analog, "8"6Rb. This volume regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swelling-induced K flux was eliminated if intracellular chloride was replaced by nitrate and both swelling-activated K influx and efflux were partially inhibited by 1 mM furosemide or bumetanide. K influx in swollen hemoglobin CC cells was not diminished when Na in the incubation medium was replaced with choline, indicating Na independence of the swelling-induced flux. Identical experiments with hemoglobin AA cells also demonstrated a swelling-induced increase in K flux, but the magnitude and duration of this increase were considerably less than that seen with hemoglobin CC cells. The increased K flux in hemoglobin AA cells was likewise sensitive to anion replacement and to ...

309

British Library Electronic Table of Contents (United Kingdom)

Background & AimsMolecular mechanisms underlying alcoholic liver disease (ALD) are still not fully understood. Activating transcription factor-4 (ATF4) is the master coordinator of the integrated stress response (ISR), an adaptive pathway triggered by multiple stressors. which can promote cell death and induce metabolic dysregulation if the stress is intense or prolonged. The aim of this study was to assess the effect of alcohol on the ISR signaling pathway in human liver cells and to define the role of cytochrome P450 2E1 (CYP2E1) in this response. MethodsPrimary cultured human hepatocytes and human HepG2 cells over-expressing CYP2E1 by adenoviral infection were exposed to ethanol (25-100mM) for 8-48h. ResultsEthanol treatment of both liver cells up-regulated ATF4 as well as the pro-survi...

2011-01-01

310

A novel small-molecule inhibitor of NF-#kappa#B signaling

A kinetic and microautoradiographic study of sup 14 C-sucrose translocation into developing wheat grains

The inducible transcription factor NF-#kappa#B regulates divergent signaling pathways including inflammatory response and cancer development. Selective inhibitors for NF-#kappa#B signaling are potentially useful for treatment of inflammation and cancer. NF-#kappa#B is canonically activated by preferential disposal of its inhibitory protein; I#kappa#B, which suppresses the nuclear translocation of NF-#kappa#B. I#kappa#B#alpha# (a major member of I#kappa#B family proteins) is phosphorylated with an I#kappa#B kinase (IKK) and subsequently polyubiquitylated by SCF"#beta#"T"r"C"P"1 ubiquitin-ligase in the presence of E1 and E2 prior to proteasomal degradation. Here, we describe a novel inhibitor termed GS143, which suppressed I#kappa#B#alpha# ubiquitylation, but not I#kappa#B#alpha# phosphorylation, MDM2-directed p53 ubiquitylation, and proteasome activity in vitro. GS143 markedly suppressed the destruction of I#kappa#B#alpha# stimulated by TNF#alpha# and a set of ...

2008-04-18

311

Use of real-time Fourier Transform Infrared Reflectivity as an in situ monitor of YBCO film growth and processing

The kinetics of {sup 14}C-photosynthate import by developing wheat grains was followed after pulse-labeling the flag leaf with {sup 14}CO{sub 2}. Samples were collected from four successive points along the transport pathway to and within the grain: exuding aphid stylets on the peduncle, exuding grain pedicels, the grain crease tissues, and the liquid contents of the endosperm cavity. In addition, microautoradiographs were prepared of the grain crease tissues during movement of the {sup 14}C pulse into the grain. At all times, sucrose accounted for 93 to 97% of the total {sup 14}C present at all four sampling sites. The main features of the {sup 14}C kinetics could be accounted for by a simple compartmental model consisting of sucrose pools in series. Microautoradiographs of the crease tissues showed fairly uniform labeling of vascular parenchyma at all times, with a sharp gradient in labeling across the chalaza to the nucellus. Thus the principal resistance to ...

1991-05-01

312

The calculation of derived release limit on Wolsung NPPs based on reduced public dose limit

Fourier Transform Infrared (FTIR) spectroscopy has been utilized during high rate E-beam evaporation/deposition of YBa2Cu3O7 (YBCO). The results demonstrate the great utility of FTIR as an in situ monitor of YBCO deposition and processing. We detect different (amorphous/fine polycrystalline) insulating pre-existing phases to the high Tc superconducting phase which appear to have distinct reflectivity fingerprints dominated by thin film interference effects, as a function of temperature and oxygen pressure. These fingerprints reveal some of the kinetic and thermodynamic pathways during the growth of YBCO.

2007-01-01

313

Technology and international climate policy

According to enactment of reduced dose limit based on ICRP-60, the calculation of Derived Release Limits(DRL) on Wolsung NPPs was carried out. There are two methods of determination on DRL; that is MPC(Maximum Permissible Concentration) method and system analysis method. In order to use the system analysis method, lots of environmental data are necessary and complicated exposure pathway are considered. So we intend to apply MPC method that is sort of simple. In addition the calculated results were compared with derived release limit on Canadian nuclear power plant.

2000-10-01

314

Search for a Methanopyrus-proximal last universal common ancestor based on comparative-genomic analysis

Both the nature of international climate policy architectures and the development and diffusion of new energy technologies could dramatically influence future costs of reducing global emissions of greenhouse gases. This paper explores the implications of interactions between technology availability and performance and international policy architectures for technology choice and the social cost of limiting atmospheric CO2 concentrations to 500 ppm by the year 2095. Key issues explored in the paper include the role of bioenergy production with CO2 capture and storage (CCS), overshoot concentration pathways, and the sensitivity of mitigation costs to policy and technology.

2006-03-15

315

British Library Electronic Table of Contents (United Kingdom)

The origin of life is a long-standing mystery puzzling many people. This mystery possesses not only philosophical but also important biological significance. To unveil this mystery, the searches for the root of life, or the last universal common ancestor (LUCA), based on comparative-genomic analysis have been intensively performed on rRNAs, tRNAs and proteins sequences. The current search pointed to a Methanopyrus-proximal LUCA, which opens up the reconstruction of Lucan biology and helps to delineate the evolutionary pathways.

2011-01-01

316

Osmoregulation in methanogens. Progress report, May 15, 1991--January 15, 1993

Osmoregulation in methanogens

Our major goal of our work has been to develop and use NMR techniques to study how methanogenic archaebacteria deal with osmotic stress with the hope of providing insights into increasing the salt tolerance of other cells. The project has three main sections: (i) in vivo studies of methanogens; (ii) use of {sup l3}C- and {sup l5}N- labeled potential precursors and in vitro analyses of specific label uptake for elucidation of osmolyte dynamics and biosynthetic pathways of osmolytes in these organisms, and isolation of key biosynthetic enzymes; and (iii) collaborative studies on identification of organic solutes in other methanogens.

1993-01-01

317

Numerical simulation of trace tests in atmosphere in Daya Bay nuclear power site

Our major goal of our work has been to develop and use NMR techniques to study how methanogenic archaebacteria deal with osmotic stress with the hope of providing insights into increasing the salt tolerance of other cells. The project has three main sections: (i) in vivo studies of methanogens; (ii) use of [sup l3]C- and [sup l5]N- labeled potential precursors and in vitro analyses of specific label uptake for elucidation of osmolyte dynamics and biosynthetic pathways of osmolytes in these organisms, and isolation of key biosynthetic enzymes; and (iii) collaborative studies on identification of organic solutes in other methanogens.

1993-01-01

318

Inborn Errors of Metabolism Presenting in Childhood

The validation of the forecast model for early emergency response to nuclear accidents is evaluated by trace tests in atmosphere in Daya Bay nuclear power site. The simulation experiment of the Daya Bay nuclear power site shows that the particle spreading image and the time-integrated concentration distribution given by plume concentration prediction model can perform the variation of pathway of the pollutant transport, as well as the effects of topography on transport and diffusion of pollutants. The simulation of five trace tests in field shows that 59.1% of ratios between predicted results and observed results are within the range of 10, and 41% of ratios are within the range of 5 approximately. (authors)

2005-09-01

319

British Library Electronic Table of Contents (United Kingdom)

Abstract Neurodegenerative and neurometabolic disorders may cause significant morbidity and mortality in children. Imaging is important in early diagnosis of metabolic disorders and in determining the extent of brain injury. Especially after the development of new techniques such as diffusion-weighted magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), neuroimaging plays more important role in the diagnosis and management of these disorders. In these disorders, usually a mutation causes a clinically significant block in one or more metabolic pathways. This blockage usually results in either a deficiency of the product or in an accumulation of substrate with damage induced by either storage or toxicity. The presenting symptoms are usually nonspecific. In some of the ...

2011-01-01

320

Immunity and tolerance to infections in experimental hematopoietic transplantation

British Library Electronic Table of Contents (United Kingdom)

Resistance and tolerance are two types of host defense mechanisms that increase fitness in response to fungi. Several genetic polymorphisms in pattern recognition receptors, most remarkably Toll-like receptors (TLRs), have been described to influence resistance and tolerance to aspergillosis in distinct clinical settings. TLRs on dendritic cells pivotally contribute in determining the balance between immunopathology and protective immunity to the fungus. Epithelial cells also contribute to this balance via selected TLRs converging on indoleamine-2,3-dioxygenase (IDO). Studies in experimental hematopoietic transplantation confirmed the dichotomy of pathways leading to resistance and tolerance to the fungus providing new insights on the relative contribution of the hematopoietic/nonhematopoi...

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Common envelope evolution

British Library Electronic Table of Contents (United Kingdom)

The common envelope phase of binary star evolution plays a central role in many evolutionary pathways leading to the formation of compact objects in short period systems. Using three dimensional hydrodynamical computations, we review the major features of this evolutionary phase, focusing on the conditions that lead to the successful ejection of the envelope and, hence, survival of the system as a post common envelope binary. Future hydrodynamical calculations at high spatial resolution are required to delineate the regime in parameter space for which systems survive as compact binary systems from those for which the two components of the system merge into a single rapidly rotating star. Recent algorithmic developments will facilitate the attainment of this goal.

2010-01-01

322

Annual Radiological Environmental Monitoring Program Report for the Fort St. Vrain Independent Spent Fuel Storage Installation (2005)

Annual Radiological Environmental Monitoring Program Report for the Fort St. Vrain Independent Spent Fuel Storage Installation

This report presents the results of the 2003 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Fort St. Vrain Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the predominant radiation exposure pathway, direct radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

2001-02-01

323

"1H MR spectroscopy in pediatrics

This report presents the results of the 2001 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Fort St. Vrain Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the predominant radiation exposure pathway, direct and scattered radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

2002-02-01

324

Surveillance and control. A new edition of the BETCGB guidebook for the control of dams in exploitation; Surveillance et controle. Une nouvelle edition du guide du BETCGB pour le controle des barrages en exploitation

Spectral appearance and concentrations of the most prominent metabolites are affected by brain development. This knowledge is essential for the detection of pathological changes in pediatric patients. This paper discusses specific conditions of MR spectroscopic examination of children and the effects of age on MR spectra quality and quantitation of the studied metabolites. Clinical examples show several diseases that are reflected in changes in "1H MR spectra due to pathological alterations in the biochemical pathways of the observed metabolites. Attention is given to the main metabolites such as N-acetylaspartate, creatine/phosphocreatine, cholines, lactate, inositol, etc.

2008-08-01

325

Hybrid ventilation. Control strategies for hybrid ventilation, consequences for air quality, thermal comfort and energy use; Hybrid ventilasjon

The French office for technical studies and control of big dams (BETCGB), has recently reedited the `guidebook for the control of dams in exploitation`. The aim of this document is to provide to the regional directions of industry, research and environment (DRIRE) a methodological help for their control actions of hydroelectric dams granted for exploitation. It comprises 6 chapters dealing with: the different type of dams, the inspection, the surveillance, the floods evacuation, the flood instructions, and the particular emergency plans. (J.S.)

1998-12-31

326

Instrumentation/control systems for small- to medium-size steel-making plants; Tekko setsubi chusho plant no keisoku seigyo system

This article deals with the need for control strategies and control systems in buildings with hybrid ventilation. In this respect, control strategies are methods of keeping certain parameters like temperature, air quality etc within specified limits. A control system is automatic and includes sensors, motors, dampers etc. The article also discusses consequences with respect to thermal comfort, air quality and energy use following selection of control parameters for controlling air masses.

2001-07-01

327

Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site Characterization Project: Quality Assurance Project Plan; Quarterly technical progress report, January 1, 1993--March 31, 1993

Fuji Electric has realized highly reliable and functional control systems by the dispersion type control system FOCUS, which uses the controller (ICS-2000) enjoying good reputation in controlling industrial plants for a long time and a personal computer with high windows operability, the former for controlling and the latter for MHI responsible for monitoring. The smelting process in a steel-making plant needs a highly reliable system for advanced control to ensure continuous operation. Fuji Electric delivered the FOCUS system to Kubota in 1998, as the smelting furnace instrumentation/control system for the cupola furnace. The system has been in service smoothly. Moreover, a total of four control systems have been delivered, 2 for steel-making furnaces and the other 2 for continuous casting. (NEDO)

1999-01-10

328

Feedwater control device for a reactor

Studies continued on organic tracers for use as hydrologic tracers as part of the Yucca Mountain Site Characterization project. This subject report for the quarter 01/01/93 through 03/31/93 discusses the following issues: project organization and responsibilities; quality assurance program; design control; procurement document control; instructions, procedures, and drawings; document control; control of purchased items and services; identification and control of items; control of processes; inspection; test control; control of measuring and test equipment; handling, storage, and shipping; inspection, test, and operating status; control of nonconforming items and conditions; corrective action; quality assurance records; audits; software quality assurance; and scientific investigation.

1993-02-25

329

Coordinated control of multiple manipulator systems

Purpose: To stably control the reactor water level so as not to cause excess water feeding in a BWR type reactor. Constitution: A flow control valve is disposed to the exit of a feedwater pump for a nuclear reactor and the valve is controlled by a flow regulator to maintain the water level constant in the reactor. A signal from a water level controller is inputted to the flow regulator to thereby control the flow rate control valve. In this case, the flow regulator remains in a saturated state just after the starting of the feedwater pump, in which the pump flowrate is at 100% to result in an excess water feeding condition. In view of the above, a feedback circuit is provided to the flow regulator so that the saturated state is eliminated and the water feeding can be controlled directly from the water level controller. ...

1981-11-12

330

Studies of neural networks for engine control: application to the electromechanical valves engine; Etudes des reseaux de neurones pour le controle moteur: application a soupapes electromecaniques

A scheme for controlling multimanipulator systems is presented. The control objective is to coordinate the manipulators to perform parts-matching tasks such as screwing a nut onto a bolt. The task of moving a rigid object can be treated as a special case. Two secondary control objectives internal force control and load distribution can be accomplished within the structure of the control law. The internal force control mechanism keeps the internal forces on the object being manipulated at a desirable level. The load distribution mechanism distributes control effort to each manipulator according to a weighting factor. It is also shown that the control algorithm has a modular structure which facilitates its implementation on a multiprocessor computer. The scheme was tested on a planar scara type dual-manipulator system. A ...

1993-08-01

331

Predictive wavefront control for Adaptive Optics with arbitrary control loop delays

This paper deals with the control of an electromechanical valves engine. The control uses neural networks in order to build a non-linear model of engine filing which depends on the driven inlets. The aim is to build this real-time model and to integrate this model to a control system which performs an iterative inversion. (J.S.)

1997-12-31

332

Overall control and monitoring systems for pumped storage plants

We present a modification of the closed-loop state space model for AO control which allows delays that are a non-integer multiple of the system frame rate. We derive the new forms of the Predictive Fourier Control Kalman filters for arbitrary delays and show that they are linear combinations of the whole-frame delay terms. This structure of the controller is independent of the delay. System stability margins and residual error variance both transition gracefully between integer-frame delays.

2007-10-30

333

Mobile and Marine Robotics

Experience and technical innovations in power plant engineering have resulted in continuous improvements of operation control, availability and safety of pumped storage plants. Process control is constantly improved as new developments are made in equipment and systems engineering. Plant control concepts with increasingly complex automation hierarchy are described by which pumped storage processes can be controlled optimally, reliably, and automatically.

1982-01-01

334

Dynamics and controls working group summary

University research group with research areas: * Land based and submersible autonomous robots, (UUVs: AUVs and ROVs); * Controllers, electronics, sensor design and fusion, motion control; * Guidance and navigation of underwater vehicles; * AI, neural networks, fuzzy logic, subsumption control, behaviour based control; * Optical fibre and ultrasonic sensors for proximal object detection; * Robot arm control, visual servoing; * Imaging sonar applications; * Simulator development: UUV simulator; imaging sonar simulator; Aircraft/flight simulator.

2007-07-01

335

Studies of real-time adaptive optimal excitation controller and adaptive optimal power system stabilizer

The technology status of the dynamics and controls discipline as it applies to energy storage wheel systems was evaluated. No problems were identified for which an adequate solution could not be proposed. Design issues that influence control were addressed. The dynamics and control aspects associated with the energy storage system concept and its various constituent parts, and the control tasks attendant to large, manned spacecraft are discussed.

1984-11-01

336

Reweighting of Sensory Inputs to Control Quiet Standing in Children from 7 to 11 and in Adults

Use of an adaptive optimal control algorithm for two realtime control applications, optimal excitation control of a synchronous generator (OEC) and power system stabilizer (PSS) is described in this paper. Experimental studies on a physical model of a power system show that the proposed OEC and PSS can track the controlled system by parameter identification at different operating conditions. The proposed control algorithm is based on the linear optimal control theory and a special 5th order discrete Riccati equation is solved in each sampling period. The proposed OEC and PSS can always guarantee that in closed loop the controlled system is stable based on the identified parameters. As the actual output of the controlled system and control are directly used in the controller, no ...

1992-09-01

337

Remote control monitoring - a review of the latest equipment

How sensory organization for postural control matures in children is not clear at this time. The present study examined, in children aged 7 to 11 and in adults, the postural control modifications in...Full Text Available

338

Overall control and monitoring systems for pumped storage plants

This article reviews briefly a range of the latest monitoring and controlling equipment for use in coal mines. This includes pressure transmitters, shale/coal discriminator, nucleonic bunker level indicator, automatic steering and monitoring system, oscilloscope/multimeter, and microprocessor based digital display controllers. 1 fig.

1988-01-01

339

OPTIMIZATION OF COMBINED SEWER OVERFLOW CONTROL SYSTEMS

The article describes control and monitoring concepts in which the delegation of responsibility is becoming more decisive than ever (automation hierarchy), and which are capable of optimized, automatic control of process events in pumped storage plants. 8 refs.

1982-06-01

340

Modular control of human walking: Adaptations to altered mechanical demands

The highly variable and intermittent pollutant concentrations and flowrates associated with wet-weather events in combined sewersheds necessitates the use of storage-treatment systems to control pollution.An optimized combined-sewer-overflow (CSO) control system requires a manage...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Decentralized fuzzy control of multiple nonholonomic vehicles

Studies have shown that the nervous system may adopt a control scheme in which synergistic muscle groups are controlled by common excitation patters, or modules, to simplify the coordination...Full Text Available

2010-02-10

342

Controlled Bidirectional Quantum Direct Communication by Using a GHZ State

This work considers the problem of controlling multiple nonholonomic vehicles so that they converge to a scent source without colliding with each other. Since the control is to be implemented on simple 8-bit microcontrollers, fuzzy control rules are used to simplify a linear quadratic regulator control design. The inputs to the fuzzy controllers for each vehicle are the (noisy) direction to the source, the distance to the closest neighbor vehicle, and the direction to the closest vehicle. These directions are discretized into four values: Forward, Behind, Left, and Right, and the distance into three values: Near, Far, Gone. The values of the control at these discrete values are obtained based on the collision-avoidance repulsive forces and the change of variables that reduces the motion control problem of each nonholonomic vehicle to a ...

1997-09-01

343

Complete programming documentation for ECIP expansion of existing Energy Monitoring and Control System (EMCS), Fort Leonard Wood, Missouri

A controlled bidirectional quantum secret direct communication scheme is proposed by using a Greenberger-Horne-Zeilinger (GHZ) state. In the scheme, two users can exchange their secret messages simultaneously with a set of devices under the control of a third party. The security of the scheme is analysed and confirmed.

2006-07-01

344

Closing the loop In Practice to Assure the Desired Performance

The objective of this project is to reduce energy consumption in 203 buildings by providing a new EMCS (Energy Monitoring Control System) to control and monitor systems.

1993-12-01

345

Case-control study of hydrocarbon exposures in patients with renal cell carcinoma.

A closed loop control process assures that a system performs within control limits. In closed loop control, the system's output feeds back directly to change the system's inputs. We describe an approach...Full Text Available

2008-01-01

346

40 CFR 52.1426 - Original identification of plan section.

A retrospective case-control study tested the hypothesis that exposure to hydrocarbon combustion products is associated with the development of renal cell carcinoma. One control per case, matched for...Full Text Available

1989-06-01

347

Performance of static var compensator control type thyristor controlled reactor and thyristor switched capacitor

...Department of Environmental Control to ASARCO Incorporated. (B) Amended Administrative...Department of Environmental Control to ASARCO Incorporated. (C) Second Amended...Department of Environmental Control to ASARCO Incorporated. (ii) Additional...

2010-07-01

348

Method and system for controlling the idle speed of an internal combustion engine at variable ignition timing

This paper has the objective of presenting the philosophy of Static Var Compensator (SVC) Control as well the necessary adjustments in the project of control system to guarantee suitable performance under different operating conditions. The verification on the performance of the SVC control has been done by Transient Network Analyzer (TNA/CEPEL) studies, commissioning tests and a factory tests. The SVC is the type of Thyristor Controlled Reactor (TCR) and Thyristor Switched Capacitor (TSC). (author) 3 refs., 12 figs.

1994-12-31

349

Method and apparatus for operation of a dual fuel compression ignition combustion engine

The idle speed of an internal combustion engine is controlled in response to a variable ignition timing control signal from a microcomputer. The microcomputer derives this control signal as a function of the magnitude of engine speed variation which occurs during engine idle periods to cause the ignition timing to vary quickly in response to a transitory engine load variation. An auxiliary air delivery system may be advantageously incorporated in the idle speed control system to cooperate with the ignition timing control in response to the engine speed variation.

1984-05-08

350

Linearization of Valve Flow Characteristics for Steam Turbine Control

A dual fuel engine control system for controlling the power output of a dual fuel compression ignition engine. The engine includes mixing means for combining an oxidizer and a primary fuel at a substantially constant ratio of oxidizer to primary fuel. The power output of the engine is controlled through the use of a throttle valve controlling the quantity of combustible mixture delivered to the combustion chamber. The fuel control system minimizes the quantity of ignition fuel required by controlling the quantity of combustible mixture rather than the fuel of air ratio. (author) figs.

1994-03-03

351

Linearization of Valve Flow Characteristics for Steam Turbine Control

The control valve for a large steam turbine must be operated linearly to be run by an automatic control system in a power plant. It is, however, found that the flow increase is much greater for a given valve position change near the closed end of travel than it is near the open end. Accordingly, the desired linearization will be achieved if the valve is opened less near the closed end of travel and greater near the open end. The previous way for linearization was to utilize the cams, which is called the mechanical hydraulic control (MHC). The MHC was afterward improved by producing the nonlinear electric compensation to the nonlinear system of control valves, viz. the electro hydraulic control (EHC)

2009-10-15

352

Selection, Training, and Control Problems in the Use of the ...

The control valve for a large steam turbine must be operated linearly to be run by an automatic control system in a power plant. It is, however, found that the flow increase is much greater for a given valve position change near the closed end of travel than it is near the open end. Accordingly, the desired linearization will be achieved if the valve is opened less near the closed end of travel and greater near the open end. The previous way for linearization was to utilize the cams, which is called the mechanical hydraulic control (MHC). The MHC was afterward improved by producing the nonlinear electric compensation to the nonlinear system of control valves, viz. the electro hydraulic control (EHC)

2009-10-01

353

SFPH protocol for the quality control of scintillation cameras. Protocole SFPH pour le controle de qualite des cameras a scintillations en mode planaire

... Title : Selection, Training, and Control Problems in the Use of the Military Working Dog. Descriptive Note : Final rept. 15 Jan 72-14 Sep 73,. ...

1974-04-02

354

Proposal for the award of a blanket purchase contract for the supply of electronics subracks for the CERN accelerator control system

Short communication.

1993-01-01

355

Probiotic Bacteria as Biological Control Agents in Aquaculture

Proposal for the award of a blanket purchase contract for the supply of electronics subracks for the CERN accelerator control system

2010-01-01

356

Power system stabilizer based on inverse dynamics using an artificial neural network

There is an urgent need in aquaculture to develop microbial control strategies, since disease outbreaks are recognized as important constraints to aquaculture production and trade and since the development...Full Text Available

2000-12-01

357

Neomusotima Fuscolinealis (Lepidoptera: Pryalidae) is an Unsuitable Biological Control Agent of Lygodium japonicum

A stable power system stabilizer (PSS) based on the inverse dynamics of the controlled system using an artificial neural network (ANN) is suggested to enhance the dynamic performances of a power system. First, an output feedback control law is driven with some conditions satisfied, which guarantees the internal stability and robustness against the asymptotically stable external disturbances. Then the control law is implemented using the inverse dynamics of the controlled plant. The inverse dynamics of the controlled plant is identified by an ANN, inverse dynamics neural network (IDNN), off-line. The pole-shifting technique and a scaling factor are introduced for the control system to meet the conditions for internal stability and robustness. The proposed controller is applied to a typical single-machine infinite-bus power system. Simulation ...

1996-06-01

358

Modeling and Control of Airport Queueing Dynamics under Severe ...

... la polilla fueron importadas a la facilidad de cuarentena en el Laboratorio de Control Biológico de Florida, ... ...

359

Managing diverse stakeholders in enterprise systems projects: a control portfolio approach

air traffic controllers at BOS tower and Terminal Radar Ap- .... Runway ) @ Runway. Buffer. Queue. Runway. Stochastic Delay. (M/1 server). (Runway to Fix). ,I, ...

360

British Library Electronic Table of Contents (United Kingdom)

While substantial research has examined the control of information systems (IS) projects, most studies in this area have only examined how one controller manages a single group of controllees. However, many IS projects, especially enterprise systems projects (often initiated by an organization's corporate headquarters, and involving business unit users and consultants), have multiple stakeholders. The corporate headquarters (the project's principal controller) must simultaneously ensure that the various stakeholders are aligned with the project's goals despite their diverse motivations, and that the stakeholders collaborate with each other to achieve project success. Behavior control theory argues that the controller enacts a control portfolio of formal and informal controls. However, the ...

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Managing Cancer Pain

MODELING AND BIOLOGICAL CONTROL OF MOSQUITOES

Despite the existence of effective analgesic drugs, many cancer patients live and die with ineffective pain control. The control of cancer pain is largely achievable with the appropriate use of available...Full Text Available

1984-02-01

362

Industrial-process control valves Part2 : Flow capacity Section Four : Inherent flow characteristics and rangeability

Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available

2007-01-01

363

Implementation and Evaluation ... - Intelligent Systems Division - NASA

Industrial-process control valves Part2 : Flow capacity Section Four : Inherent flow characteristics and rangeability

1989-01-01

364

Facilitator control as automatic behavior: A verbal behavior analysis

[9] Rysdyk, R. T., and Calise, A. J., Fault Tolerant Flight control via Adaptive Neural Augmentation, AIAA. Guidance, Navigation, and Control Conference, Aug. ...

365

Explosives - hazard management

Several studies of facilitated communication have demonstrated that the facilitators were controlling and directing the typing, although they appeared to be unaware of doing so. Such results shift...Full Text Available

1993-01-01

366

Experimental assessment of energy storage via variable speed compressor

The management of risks of explosives are described. Administrative and procedural controls are considered. The safety management plan involves hazard identification, risk analysis, assessment and control. The current position of explosives safety is considered. 4 tabs.

1998-12-31

367

British Library Electronic Table of Contents (United Kingdom)

In this study, usage of a variable speed refrigeration system in latent heat thermal energy storage (LHTES) system is investigated to increase energy storage efficiency. Four different compressor speed control cases are compared to obtain a constant heat transfer fluid (HTF) temperature at the inlet of the energy storage tank. These control cases are (i) control with evaporation temperature, (ii) control with ethylene glycol temperature at the outlet section of evaporator, (iii) control with suction pressure of the compressor and (iv) on/off control. By means of the experimental analysis the best control strategy is obtained as control with Case (ii), in terms of stability of inlet temperature of heat transfer fluid, variations of energy efficiency of LHTES and coefficient of performance (...

2011-01-01

368

Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine

Design of the electromagnetic actuator for vibration control of a flexible rotor

AbstractThe efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial...Full Text Available

2004-01-01

369

Design of the decision aiding system for the control of the research nuclear reactor; Conception d'un systeme d'aide a la decision pour le controle d'un reacteur nucleaire de recherche

In order to suppress resonance vibrations of a rotor-shaft of rotating machinery, a rotor-shaft system elastically supported by ball bearings which are installed in electromagnetic actuators are proposed and the design method of some compensatory circuits in the controller to control the electromagnetic actuators in the system are explained. These actuators are controlled by the analog PID (proportional, integral, and derivative) controller. The compensation for nonlinearity of electromagnetic force, the negative stiffness of electromagnet, and the time lag of the coil current are discussed and the effective control circuits are proposed. The rotor-shaft system is replaced by the equivalent two-degree-of-freedom system and both impulse and frequency responses are numerically simulated for several parameters of PD-controller gain. By applying the principle of ...

1994-12-21

370

Intelligent and decision aiding systems as support to operators are becoming increasingly a necessity in nuclear installations and in nuclear reactors in particular, specially after the Tree Mile Island. Development of new technologies based on linguistic approaches such as fuzzy logic has given rise to much interest during the last years. Fuzzy logic controller (FLC) has many advantage compared to conventional controllers using classical techniques. The aim of the present work is to use a fuzzy logic controller in parallel to actual semi-automatic controller in order to supervise in real time the operation of the research nuclear reactor. The principal of this controller is based on rules which are established previous from experiment using the semi-automatic controller and from the knowledge of the operators. (authors)

2003-07-01

371

Control rod devices

Control of Host Cell Phosphorylation by Legionella Pneumophila

Purpose: To remove excessive driving pressure applied to an unisolated control rod drive by returning excessive coolant to a condensed water storage tank or to the inlet side of a drive water pump using a coolant flow rate control pipe of a control rod driving hydraulic system. Constitution: Excessive water is returned to a condensed water tank while controlling the excessive coolant by a flow control valve in response to variations in the pressure difference between the reactor pressure and the driving water line when the control rods are isolated using a pipe from the outlet side of the drive water pump to the condensed water storage tank. Thus, the control rod to be isolated is prevented form being dropped. (Sekiya, K.).

372

Computer Controlled Telerobot Wrist Module

Phosphorylation is one of the most frequent modifications in intracellular signaling and is implicated in many processes ranging from transcriptional control to signal transduction in innate immunity....Full Text Available

373

Comparative genomics of insect juvenile hormone biosynthesis?

Disclosed in this proposal are plans to construct a patent pending wrist module with computer control, configurable to form high-dexerity telerobotic arms ...

374

Clinical Investigation Program, Reports Control Symbol MED ...

The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular...Full Text Available

2006-04-01

375

Bioelectric Control of Prostheses.

... POG Cook, BA A Case Control Study of Childhood 147 8552(85) Rhabdomyosarcoma (0) POG COOK, BA Phase II Study of 6-Mercaptopurine ...

1988-10-01

376

Application of chloropicrin to Douglas-fir stumps to control laminated ...

Externally powered prostheses have been studied for many years, to provide more effective rehabilitation of amputees. To take advantage of the benefits offered by external power in prostheses, however, the mode of control of the prosthesis by the amputee ...

1966-01-01

377

Antihypertensive Agents in Hemodialysis Patients: A Current Perspective

Sep 1, 2011 ... Title: Application of chloropicrin to Douglas-fir stumps to control laminated root rot does not affect infection or growth of regeneration 16 growing ...

378

Advanced Monitoring and Control of Multi monomer System in Emulsion Polymerization

Hypertension affects most hemodialysis patients and is often poorly controlled. Adequate control of blood pressure is difficult with conventional hemodialysis alone but is important to improve...Full Text Available

2010-05-01

379

British Library Electronic Table of Contents (United Kingdom)

Abstract A control framework was developed for real time implementation of optimal control of emulsion polymerization with multiple monomers by integrating model based algorithms with software engines. The developed system was applied for controlling conversion, particle size, molar mass, and polymer composition using model predictive control (MPC) based on mechanistic models for emulsion polymerization. The control formulation was extended to account for existing process constraints on the input, input moves, and solids content. On experimental testing, the developed control scheme was found to achieve the desired objectives without violating the process constraints and showed good robustness in rejecting disturbances. Improvements in the process operation and polymer property control wer...

2010-01-01

380

AIR ... - Human Factors Research and Technology Division - NASA

AFSPC Corrosion Control Program - NASA

TRACON controller, traffic flow manager, or pilot. .... separation violations to individual controller and ..... System, AGARD Meeting on Machine Intelligence ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

A neuro power system stabilizer based on adaptive control technique

HQ AFSPC/LG / CORR.PPT. 2. 01/16/02. UNCLASSIFIED. UNCLASSIFIED. Overview. " Corrosion Control Areas. " Support Activities. " Test Projects ...

382

A review of the gas species activity and control of pulsed plasma technology during the nitriding, carburizing and carbonitriding processes

A power system stabilizer based on GMV (Generalized Minimum Variance), one of the adaptive control techniques, is developed to enhance the dynamic performances of a power system using an Artificial Neural Network (ANN). The stabilizer consists of two parts. One part is Inverse Dynamics Neural Networks (IDNN), which is trained to identify the inverse dynamics of controlled plant and used as a one-step ahead controller, or inverse controller. The other part is Adaptive Reference Model (ARM), which prevents excessive controller output. The ARM produces the modified reference value by minimizing a cost function recursively on the assumption that the IDNN perfectly identifies the controlled plant. The IDNN is used in the minimization procedure to calculate the sensitivities. The proposed controller is simulated in a typical ...

1996-12-31

383

[Conversion of acetic acid to methane by thermophiles

The control of gas activity and process technology has developed tremendously over the past two decades. While once considered to be primitive control systems using simple PID loops with thermocouples that were suspect and unable to perform repeatedly and consistently during the arduous process of plasma nitriding and processing, developments in recent years have elevated the control of the process into what might be considered one of the most controllable processes of the latter part of this century. The advent of plasma processing technology has improved control methods by observing and harnessing each of the various process parameters into many different combinations of control systems. Some of these control systems can control the complete function of the process, thus freeing the operator entirely for other duties, ...

1995-12-31

384

Wound ballistics of gunshot injuries to the head and neck.

The primary goal of this project is to obtain a better understanding of thermophilic microorganisms which convert acetic acid to CH[sub 4]. The previous funding period represents a departure from earlier research in this laboratory, which was more physiological and ecological. The present work is centered on the biochemistry of the thermophile Methanothrix sp. strain CALS-1. this organism presents a unique opportunity, with its purity and relatively rapid growth, to do comparative biochemical studies with the other major acetotrophic genus Methanosarcina. We previously found that Methanothrix is capable of using acetate at concentrations 100 fold lower than Methanosarcina. This finding suggests that there are significant differences in the pathways of methanogenesis from acetate in the two genera.

1993-01-01

385

Wnt/b-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity

It is important for the trauma surgeon to understand the basic principles of terminal gunshot ballistics and the study of the projectile's effect on striking soft tissue. The amount of kinetic energy dissipated to the tissue is directly related to the mass and velocity of the projectile as follows: K = MV2/2. Doubling the velocity quadruples the energy, while doubling the mass only doubles the energy. A temporary tissue cavity is produced as the striking projectile compresses the surrounding tissue; the higher the energy release, the more extensive the inapparent compressive damage. The permanent cavity that remains is the result of extrusion of tissue from the pathway of the projectile. The higher the velocity, the higher the likelihood of extensive damage. If the missile expands or fragments within the tissues, more damage will occur. PMID:6847483

1983-05-01

386

British Library Electronic Table of Contents (United Kingdom)

Amyloid precursor protein (APP), a key protein in pathogenesis of Alzheimer's disease (AD), is a type I transmembrane protein which can be cleaved by b- and g-secretase to release the amyloidogenic b-amyloid peptides (Ab) and the APP intracellular domain (AICD). While Ab has been widely believed to initiate pathogenic cascades culminating AD, the physiological functions and regulations of AICD remain elusive. In present study, endogenous AICD was demonstrated to be increased by canonical Wnt signal. Instead of due to g-secretase activity, enhanced AICD expression was found due to the increased protein stability by Wnt/b-catenin. b-Catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity. Investigation by AICD mutants proved ...

2011-01-01

387

Vascular ATP-sensitive potassium channels are over-expressed and partially regulated by nitric oxide in experimental septic shock

British Library Electronic Table of Contents (United Kingdom)

Purpose To study the activation and expression of vascular (aorta and small mesenteric arteries) potassium channels during septic shock with or without modulation of the NO pathway. Methods Septic shock was induced in rats by peritonitis. Selective inhibitors of vascular KATP (PNU-37883A) or BKCa [iberiotoxin (IbTX)] channels were used to demonstrate their involvement in vascular hyporeactivity. Vascular response to phenylephrine was measured on aorta and small mesenteric arteries mounted on a wire myograph. Vascular expression of potassium channels was studied by PCR and Western blot, in the presence or absence of 1400W, an inducible NO synthase (iNOS) inhibitor. Aortic activation of the transcriptional factor nuclear factor-kappaB (NF-?B) was assessed by electrophoretic mobility shift as...

2011-01-01

388

Ultrafast resonance energy transfer in bio-molecular systems

British Library Electronic Table of Contents (United Kingdom)

In this article, we present our consistent efforts to explore the dynamical pathways of the migration of electronic radiation by using ultrafast (picosecond/femtosecond time scales) F?rster resonance energy transfer (FRET) technique. The ultrafast non-radiative energy migration from an intrinsic donor fluorophore (Tryptophan, Trp214) present in domain IIA of a transporter protein human serum albumin (HSA) to various non-covalently/covalently attached organic/inorganic chromophores including photoporphyrin IX (PPIX), polyoxovanadate [V15As6O42(H2O)]-6 clusters (denoted as V15) and CdS quantum dots (QDs) has been explored. We have also used other covalently/non-covalently attached extrinsic fluorogenic donors (NPA, ANS) in order to exploit the dynamics of resonance energy migration of an enz...

2010-01-01

389

Two-photon calcium imaging from head-fixed Drosophila during optomotor walking behavior

British Library Electronic Table of Contents (United Kingdom)

Drosophila melanogaster is a model organism rich in genetic tools to manipulate and identify neural circuits involved in specific behaviors. Here we present a technique for two-photon calcium imaging in the central brain of head-fixed Drosophila walking on an air-supported ball. The ball's motion is tracked at high resolution and can be treated as a proxy for the fly's own movements. We used the genetically encoded calcium sensor, GCaMP3.0, to record from important elements of the motion-processing pathway, the horizontal-system lobula plate tangential cells (LPTCs) in the fly optic lobe. We presented motion stimuli to the tethered fly and found that calcium transients in horizontal-system neurons correlated with robust optomotor behavior during walking. Our technique allows both behavior ...

2010-01-01

390

Tungsten Effects on Phosphate-Dependent Biochemical Pathways are Species and Liver Cell Line Dependent

British Library Electronic Table of Contents (United Kingdom)

Tungsten, in the form of tungstate, polymerizes with phosphate, and as extensive polymerization occurs, cellular phosphorylation and dephosphorylation reactions may be disrupted, resulting in negative effects on cellular functions. A series of studies were conducted to evaluate the effect of tungsten on several phosphate-dependent intracellular functions, including energy cycling (ATP), regulation of enzyme activity (cytosolic protein tyrosine kinase [cytPTK] and tyrosine phosphatase), and intracellular secondary messengers (cyclic adenosine monophosphate [cAMP]). Rat noncancerous hepatocyte (Clone-9), rat cancerous hepatocyte (H4IIE), and human cancerous hepatocyte (HepG2) cells were exposed to 1-1000 mg/l tungsten (in the form of sodium tungstate) for 24 h, lysed, and analyzed for the ab...

2010-01-01

391

The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways

British Library Electronic Table of Contents (United Kingdom)

Unlike the well-characterized nuclear function of the Notch intracellular domain, it has been difficult to identify a nuclear role for the ligands of Notch. Here we provide evidence for the nuclear function of the Notch ligand Delta-like 1 in colon cancer (CC) cells exposed to butyrate. We demonstrate that the intracellular domain of Delta-like 1 (Dll1icd) augments the activity of Wnt signaling-dependent reporters and that of the promoter of the connective tissue growth factor (CTGF) gene. Data suggest that Dll1icd upregulates CTGF promoter activity through both direct and indirect mechanisms. The direct mechanism is supported by co-immunoprecipitation of endogenous Smad2/3 proteins and Dll1 and by chromatin immunoprecipitation analyses that revealed the occupancy of Dll1icd on CTGF promot...

2011-01-01

392

Superheavy elements with the Berkeley gas-filled separator

Study of Zircaloy-2 corrosion in high temperature water using ion beam methods

In April and May of 1999 the Berkeley Gas-filled Separator was used to search for the production and decay of element 118 from the {sup 86}Kr + {sup 208}Pb reaction, according to Smolanczuk's predictions of relatively large production rates. Three decay chains, each consisting of an implanted heavy ion, followed by a rapid (ms) succession of high-energy (>10 MeV) alpha-particle decays were detected. These chains are consistent with the production and decay of element 118 with mass number 293. These results a) show experimental evidence for the existence of shell-stabilized superheavy elements, b) provide experimental values for refinement of nuclear mass models in the superheavy element region, and, most importantly, c) present a new' reaction pathway for the production of superheavy elements. (author)

2000-03-01

393

Studies of the fundamental nature of catalytic acidity, sites, and intermediates: Progress report for period August 1, 1987-July 31, 1988

Experiments have been carried out in water at 355 C to study transport of oxygen and hydrogen (as deuterium) in growing corrosion films. Composition of the films was also examined in 2.9 Mev and 3.9 Mev /alpha/-particle backscattering experiments. Corrosion occurs predominantly by oxygen diffusion through the film via grain boundary or similar short circuit diffusion paths, to form fresh oxide at the oxide metal interface. Increasing grain size within thick pre-breakaway films contributes to a decrease in diffusivity. The rate transition results from the generation of new diffusion pathways in previously protective oxide. Unexpectedly high concentrations of deuterium were observed. 26 refs.

1981-10-01

394

Steady-state isotopic transient kinetic analysis investigation of CO-O_2 and CO-NO reactions over a commercial automotive catalyst

Neopentane, because of its unique structural features, was found to be a useful probe for the assay of the acidity of various zeolites. The C-C bond was attacked by catalyst protons yielding CH/sub 4/ and the isobutyl carbenium ion in equal quantities. The latter either decomposed to produce isobutene or underwent secondary reactions. New avenues for reaction were opened with isobutane. The reaction of the Bronsted protons with the tertiary CH bonds produced H/sub 2/ and the same isobutyl carbenium ion. Hydride ion transfer of the same tertiary hydrogen to existing carbenium ions also occurred and the results showed that about half of the reaction was carried by this pathway. As with Neopentane, the C-C bond could also be attacked yielding the sec-propyl carbenium ion. These tools are being further developed.

1988-06-01

395

Self-inhibited rate in gas-solid noncatalytic reactions. The shrinking core model

In this paper, steady-state isotopic transient kinetic analysis (SSITKA) is used to study two model reactions, CO oxidation and CO-NO reactions, on a typical formulation of a three-way auto-catalyst. Under steady-state conditions, abrupt switches in the isotopic composition of CO ("1"2C"1"6O/"1"3C"1"8O) were carried out to produce isotopic transients in both labeled reactants and products. Along with the determination of the average surface lifetimes and concentrations of reaction intermediates, an analysis of the transient responses along the carbon reaction pathway indicated that the distribution of active sites for the formation of CO_2 was bimodal for both reactions. Furthermore, relatively few surface sites contributed to the overall reaction rate.

1991-08-25

396

Rocky Mountain Arsenal, Basin F liquid storage tank spill, draft risk assessment

The shrinking core model is examined for gas-solid noncatalytic reactions with a self-inhibited rate form and it is shown that multiple reaction pathways are possible for solid particles reacted under identical conditions. The observed reaction rate can have up to two discontinuities (jumps) during reaction for particles of spherical and cylindrical shape. The geometric instability analysis reveals that the reaction interface is stable under a very limited set of conditions only for solid particles of slab geometry. For a sphere or cylinder at large Biot numbers the reaction interface is always potentially unstable. This model provides a plausible explanation for gas-solid reactions which exhibit erratic shrinking core behavior.

1984-02-01

397

Report on NCI symposium: comparison of mechanisms of carcinogenesis by radiation and chemical agents. II. Cellular and animal models

The scope of this RA is limited to the evaluation of potential human health risks associated with a failure event of a tank containing Basin F liquid. Section 1.0 contains an introduction to the health risk assessment. Section 2.0 describes the site history, location, and land use. Section 3.0 provides a brief description of exposure pathways and potention receptors. Section 4.0 describes the sources of data used and identifies chemicals of concern. Section 5.0 discusses the toxicity of concern. Section 6.0 explains the methods used for calculation of carcinogenic risks and the noncarcinogenic hazard indexes. Section 7.0 describes uncertainties inherent in the current methodology used to determine potential human health risks. Section 8.0 presents a summary of results and conclusions. Section 9.0 includes the references cited.

1993-04-01

398

Regulation and secretion of Xanthomonas virulence factors

The point at which the common final pathway for induction of cancer by chemical carcinogens and ionizing radiation has not been identified. Although common molecular targets are suggested by recent findings about the role of oncogenes, the mechanism by which the deposition of radiation energy and the formation of adducts or other DNA lesions induced by chemicals affects the changes in the relevant targets may be quite different. The damage to DNA that plays no part in the transformation events, but that influences the stability of the genome, and therefore, the probability of subsequent changes that influence tumorigenesis may be more readily induced by some agents than others. Similarly, the degree of cytotoxic effects that disrupt tissue integrity and increase the probability of expression of initiated cells may be dependent on the type of carcinogen. Also, evidence was presented that repair of the initial lesions could be demonstrated after exposure to low-LET ...

1984-05-20

399

British Library Electronic Table of Contents (United Kingdom)

Abstract Plant pathogenic bacteria of the genus Xanthomonas cause a variety of diseases in economically important monocotyledonous and dicotyledonous crop plants worldwide. Successful infection and bacterial multiplication in the host tissue often depend on the virulence factors secreted including adhesins, polysaccharides, LPS and degradative enzymes. One of the key pathogenicity factors is the type III secretion system, which injects effector proteins into the host cell cytosol to manipulate plant cellular processes such as basal defense to the benefit of the pathogen. The coordinated expression of bacterial virulence factors is orchestrated by quorum-sensing pathways, multiple two-component systems and transcriptional regulators such as Clp, Zur, FhrR, HrpX and HpaR. Furthermore, virule...

2010-01-01

400

Radiological hazards following a nuclear emergency

Proteomic analysis of apoptosis induction in human lung cancer cells by recombinant MVL

Following the 1986 Chernobyl accident there was an understandable increase in public interest in nuclear accidents and emergency planning for them. It became clear that the broad nature, timing and scale of the radiological hazard presented by such accidents was, however, little understood. This Paper sets out in simple terms the basic features of the radiological hazard to persons in the vicinity of a nuclear power plant should a serious accident occur. The Paper starts by stressing the difference between faults -events that may occur relatively frequently - and accidents -unplanned releases of radioactivity that are by design extremely unlikely events. The Paper examines the significance of different exposure pathways and relates them to the protective measures (countermeasures) that may be taken. These countermeasures include sheltering, evacuation and the consumption of stable iodine tablets. The Paper illustrates the effectiveness of these countermeasures, ...

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British Library Electronic Table of Contents (United Kingdom)

Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic changes in A549 cells, and to identify the molecular pathways responsible for the anti-cancer action of R-MVL. We found that R-MVL induces A549 cells apoptosis in a dose-dependent manner by using MTT assay, fluorescent microscope (FM) and flow cytometry (FCM), and the IC50 was calculated to be 24.12??g/ml. Subsequently, 7 altered proteins in R-MVL-treated A549 cells were identified, including upregulated aldehyde dehydrogenase 1 and ?-actin, and five downregulated proteins: heat s...

2011-01-01

402

Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release

British Library Electronic Table of Contents (United Kingdom)

Recycling of carbon by the photorespiratory pathway involves enzymatic steps in the chloroplast, mitochondria, and peroxisomes. Most of these reactions are essential for plants growing under ambient CO2 concentrations. However, some disruptions of photorespiratory metabolism cause subtle phenotypes in plants grown in air. For example, Arabidopsis thaliana lacking both of the peroxisomal malate dehydrogenase genes (pmdh1pmdh2) or hydroxypyruvate reductase (hpr1) are viable in air and have rates of photosynthesis only slightly lower than wild-type plants. To investigate how disruption of the peroxisomal reduction of hydroxypyruvate to glycerate influences photorespiratory carbon metabolism we analyzed leaf gas exchange in A. thaliana plants lacking peroxisomal HPR1 expression. In addition, b...

2011-01-01

403

Of McKay Correspondence, Non-linear Sigma-model and Conformal Field Theory

Ocean teleconnections between Antarctica and the Equatorial Pacific and Atlantic.

The ubiquitous ADE classification has induced many proposals of often mysterious correspondences both in mathematics and physics. The mathematics side includes quiver theory and the McKay Correspondence which relates finite group representation theory to Lie algebras as well as crepant resolutions of Gorenstein singularities. On the physics side, we have the graph-theoretic classification of the modular invariants of WZW models, as well as the relation between the string theory nonlinear $\\sigma$-models and Landau-Ginzburg orbifolds. We here propose a unification scheme which naturally incorporates all these correspondences of the ADE type in two complex dimensions. An intricate web of inter-relations is constructed, providing a possible guideline to establish new directions of research or alternate pathways to the standing problems in higher dimensions.

2000-01-01

404

Nutrition and Physical Activity in Aging, Obesity, and Cancer

Objectives(i) Investigate the correlation between Antarctic sea-ice and equatorial sea-surface temperature anomalies in a realistically forced ocean model simulation of the last 50 years. (ii) Determine whether and how the enormous seasonal change in distribution of sea-ice modifies the seasonal cycle at the Equator. (iii) Determine the detailed pathways of wave propagation both in a historically-forced simulation and in response to realistic perturbations. (iv) Quantify the amplitude of the response i [continued...]DescriptionIt is well known that the equatorial ocean-atmosphere system plays a key role in global climate events such as the El Nino-Southern Oscillation (ENSO) phenomenon. There is now compelling evidence that changes in the Antarctic can strongly and quickly affect the equatorial ocean and the ENSO cycle. Observations demonstrate statistically significant correlations (teleconnections) between the Antarctic and the Equator with leads and lags of ...

2009-01-31

405

British Library Electronic Table of Contents (United Kingdom)

A wide variety of phytochemicals present in our diet, including fruits, vegetables, and spices, have been shown to possess a broad range of health-beneficial properties. The cytoprotective and restorative effects of dietary phytochemicals are likely to result from the modulation of several distinct cellular signal transduction pathways. Many dietary phytochemicals that are synthesized as secondary metabolites function as toxins, that is, -phytoalexins,- and hence protect plants against insects and other damaging organisms and stresses. However, at the relatively low doses consumed by humans and other mammals, these same toxic plant-derived chemicals, as mild stressors, activate adaptive cellular response signaling, conferring stress resistance and other health benefits. This phenomenon has...

2011-01-01

406

Nitrogen fixation in peanut nodules during dark periods and detopped conditions with special reference to lipid bodies

MGV: a generic graph viewer for comparative omics data

The peanut plant (Arachis hypogaea L.), unlike other known legumes, can sustain nitrogen fixation when prolonged periods of darkness or detopping curtail the supply of photosynthate to the nodule. This ability to withstand photosynthate stress is attributed to the presence of lipid bodies in infected nodule cells. In both dark-treated and detopped plants, the lipid bodies show a gradual decrease in numbers, suggesting their utilization as a source of energy and carbon for nitrogen fixation. Lipolytic activity can be localized in the lipid bodies, and the existence of #beta#-oxidation pathway and glyoxylate cycle is shown by the release of "1"4CO_2 from "1"4C lineoleoyl coenzyme A by the nodule homogenate.

1991-01-01

407

British Library Electronic Table of Contents (United Kingdom)

Motivation: High-throughput transcriptomics, proteomics and metabolomics methods have revolutionized our knowledge of biological systems. To gain knowledge from comparative omics studies, strong data integration and visualization features are required. Knowledge gained from these studies is often available in the form of graphs, and their visualization is especially useful in a wide range of systems biology topics, including pathway analysis, interaction networks or gene models. Especially, it is necessary to compare biological models with measured data. This allows the identification of new models and new insights into existing ones. Results: We present MGV, a versatile generic graph viewer for multiomics data. MGV is integrated into Mayday (Battke et al., 2010). It extends Maydays visual...

2011-01-01

408

Local Ce environments and their effects on optical properties of SrS phosphors

Life cycle assessment of electric mobility: answers and challenges?Zurich, April 6, 2011

In this study, we use electron paramagnetic resonance (EPR), optical absorption, and photoluminescence (PL) spectroscopies to determine the various Ce environments in SrS phosphor materials and how these affect absorption and emission properties. As the Ce concentration is increased from 450 to 7500 ppm, the total EPR-active Ce"3"+ and optical absorption signals increase linearly with Ce concentration; by contrast, the PL intensity saturates at fairly low Ce concentrations (1000 ppm Ce). We suggest that the nonlinear behavior of the PL arises from the presence of nonradiative deexcitation pathways such as defects associated with Ce sites, or Ce endash Ce pairs. copyright 1996 American Institute of Physics.

409

British Library Electronic Table of Contents (United Kingdom)

Introduction Alternative ways and means of transportation are necessary in order to reduce the environmental impacts of mobility. In the recent years, biofuels were first seen as a main option and then LCA showed also possible hazards of this development. Recently, public interest is rapidly shifting towards electromobility. Therefore it is necessary to also gain better knowledge about the environmental impacts of this technology. This includes a modelling of the pathways of the necessary increase in electricity supply and an appropriate modelling of battery manufacture. Summary of data presented At this forum most recent results of life cycle assessment studies of electric car driving compared to driving fossil- and agro-fuelled cars were presented. The environmental performance of indivi...

2011-01-01

410

Involvement of a putative response regulator Brrg-1 in the regulation of sporulation, sensitivity to fungicides, and osmotic stress in Botrytis cinerea

British Library Electronic Table of Contents (United Kingdom)

The response regulator protein is a core element of two-component signaling pathway. In this study, we investigated functions of BRRG-1 of Botrytis cinerea, a gene that encodes a putative response regulator protein, which is homologous to Rrg-1 in Neurospora crassa. The BRRG-1 gene deletion mutant ?Brrg1-62 was unable to produce conidia. The mutant showed increased sensitivity to osmotic stress mediated by NaCl and KCl, and to oxidative stress generated by H2O2. Additionally, the mutant was more sensitive to the fungicides iprodione, fludioxonil, and triadimefon than the parental strain. Western-blot analysis showed that the Bos-2 protein, the putative downstream component of Brrg-1, was not phosphorylated in the ?Brrg1-62. Real-time polymerase chain reaction assays showed that expression ...

2011-01-01

411

Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

2009-01-01

412

Hearing pathways and directional sensitivity of the beluga whale, Delphinapterus leucas

British Library Electronic Table of Contents (United Kingdom)

Odontocetes are believed to receive sounds primarily through the pan bone region of the lower jaw although much variation in jaw morphology exists among species. In order to further examine this jaw hearing hypothesis we tested the head receiving sensitivity and directional hearing of a beluga whale, Delphinapterus leucas. Hearing thresholds were measured using auditory evoked potentials (AEPs). The subject proved to have highly directional hearing for far-field click stimuli similar to that of bottlenose dolphins and more directional than the harbor porpoise. For near-field jawphone stimulation, the beluga's lowest thresholds were found when click stimuli were presented at the rostrum tip (76?dB re: 1??Pa) although thresholds from the pan bone region stimulation were only 2?3?dB higher. S...

2008-01-01

413

Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder

British Library Electronic Table of Contents (United Kingdom)

Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

2011-01-01

414

Generation of coherent states of photon-added type via pathway of eigenfunctions

Fuel cell hybrid taxi life cycle analysis

We obtain and investigate the regular eigenfunctions of simple differential operators xr dr+1/dxr+1, r = 1, 2, ..., with the eigenvalues equal to 1. With the help of these eigenfunctions, we construct a non-unitary analogue of a boson displacement operator which will be acting on the vacuum. In this way, we generate collective quantum states of the Fock space which are normalized and equipped with the resolution of unity with the positive weight functions that we obtain explicitly. These states are thus coherent states in the sense of Klauder. They span the truncated Fock space without first r lowest-lying basis states: |0), |1), ..., |r - 1). These states are squeezed, sub-Poissonian in nature and reminiscent of photon-added states in Agarwal and Tara (1991 Phys. Rev. A 43 492).

2010-09-17

415

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A small fleet of classic London Taxis (Black cabs) equipped with hydrogen fuel cell power systems is being prepared for demonstration during the 2012 London Olympics. This paper presents a Life Cycle Analysis for these vehicles in terms of energy consumption and CO2 emissions, focusing on the impacts of alternative vehicle technologies for the Taxi, combining the fuel life cycle (Tank-to-Wheel and Well-to-Tank) and vehicle materials Cradle-to-Grave. An internal combustion engine diesel taxi was used as the reference vehicle for the currently available technology. This is compared to battery and fuel cell vehicle configurations. Accordingly, the following energy pathways are compared: diesel, electricity and hydrogen (derived from natural gas steam reforming). Full Life Cycle Analysis, usin...

2011-01-01

416

Food-grade gene expression in lactic acid bacteria

British Library Electronic Table of Contents (United Kingdom)

Abstract In the 1990s, significant efforts were invested in the research and development of food-grade expression systems in lactic acid bacteria (LAB). At this time, Lactococcus lactis in particular was demonstrated to be an ideal cell factory for the food-grade production of recombinant proteins. Steady progress has since been made in research on LAB, including Lactococcus, Lactobacillus and Streptococcus, in the areas of recombinant enzyme production, industrial food fermentation, and gene and metabolic pathway regulation. Over the past decade, this work has also led to new approaches on chromosomal integration vectors and host/vector systems. These newly constructed food-grade gene expression systems were designed with specific attention to self-cloning strategies, food-grade selection...

2011-01-01

417

Fertilizer amendment for improving the phytoextraction of cadmium by a hyperaccumulator Rorippa globosa (Turcz.) Thell

British Library Electronic Table of Contents (United Kingdom)

Purpose Two main pathways of phytoremediation of heavy metal-contaminated soils are phytostabilization and phytoextraction. Some soil amendments can strengthen phytostabilization or phytoextraction through either reducing heavy metal bioavailability in soil or increasing the heavy metal accumulation capacity of the hyperaccumulator (enhancing heavy metal concentration or shoot biomass of the hyperaccumulator). Urea and chicken manure are often used as fertilizers. This research will explore their effects on a newly found hyperaccumulator, Rorippa globosa (Turcz.) Thell., phytoremediating cadmium (Cd). Materials and methods Pot culture experiment was conducted to study the accumulation characteristics of R. globosa at different Cd contamination concentrations under one fertilizer level (1?g...

2011-01-01

418

Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats

British Library Electronic Table of Contents (United Kingdom)

Objective: : Evaluate expression of inducible negative regulators of JAK/STAT pathway and their target proteins during the course of ligature-induced experimental periodontal disease in rats. Design: : Rats were sacrificed 07, 15 and 30days after disease induction for histological evaluation of periodontal inflammation and macroscopic analysis of alveolar bone loss. SOCS expression and the activation status of STAT1 and STAT3 were evaluated in gingival biopsies by real time PCR and Western blot. Results: : Ligature-induced model presented significant progressive bone loss from 7 to 30days. Inflammation was evident and similar for 07 and 15days; however, a decrease on severity at the end of the experimental period was observed. There was a significant (p<0.05) increase on SOCS1 and SOCS3 ge...

2011-01-01

419

Exploring the potential energy surface for proton transfer in acetylacetone

Environmental information document: Savannah River Laboratory Seepage Basins

The portion of the potential energy surface (PES) of acetylacetone relevant for the intramolecular proton transfer reaction is studied using ab initio and DFT methods. The best estimate of the barrier governing proton transfer was found to be 3.4 kcal mol{sup -1} at the MP4(FC)/6-311 + G(2d,2p)//MP2(FC)/6-311 + G(2d,2p) level of theory. Six stationary points on the PES were characterized as well as the reaction paths connecting these points. Special attention paid to the pathway of intramolecular proton transfer reveals that the internal rotation of the methyl group adjacent to the carbonyl group and the proton transfer reaction are consecutive processes.

2004-11-15

420

Effects of hydrous pyrolysis on biomarker thermal maturity parameters: Monterey Phosphatic and Siliceous members

This document provides environmental information on postulated closure options for the Savannah River Laboratory Seepage Basins at the Savannah River Plant and was developed as background technical documentation for the Department of Energy`s proposed Environmental Impact Statement (EIS) on waste management activities for groundwater protection at the plant. The results of groundwater and atmospheric pathway analyses, accident analysis, and other environmental assessments discussed in this document are based upon a conservative analysis of all foreseeable scenarios as defined by the National Environmental Policy Act (CFR, 1986). The scenarios do not necessarily represent actual environmental conditions. This document is not meant to be used as a closure plan or other regulatory document to comply with required federal or state environmental regulations.

1987-03-01

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421

Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: A pathway for their neuroprotective effects

Hydrous pyrolysis of immature Monterey Phosphatic or Siliceous rock at progressively higher temperatures causes systematic changes in biomarker thermal maturity parameters of the generated hydrocarbons. Biomarker ratios based on proposed carbon-carbon cracking or aromatization reactions increase during hydrous pyrolysis along similar pathways for both Siliceous and Phosphatic members. An increase in these biomarker ratios is also observed for oils of increasing thermal maturity from the offshore Santa Maria Basin, although the rates of changes for each parameter differ between the hydrous pyrolysis and natural samples. Changes in some cracking parameters during maturation appear to result from differential thermal stability of the compounds rather than conversion of precursors to products. (author).

1990-01-01

422

British Library Electronic Table of Contents (United Kingdom)

Thioredoxin reductase (TrxR) isoforms play important roles in cell physiology, protecting cells against oxidative processes. In addition to its endogenous substrates (Trx isoforms), hepatic TrxR can reduce organic selenium compounds such as ebselen and diphenyl diselenide to their selenol intermediates, which can be involved in their hepatoprotective properties. Taking this into account, the aim of the present study was to evaluate the hypothesis that ebselen, diphenyl diselenide and its analogs (4,4'-bistrifluoromethyldiphenyl diselenide, 4,4'-bismethoxydiphenyl diselenide, 4.4'-biscarboxy-diphenyl diselenide, 4,4'-bischlorodiphenyl diselenide, 2,4,6,2',4',6'-hexamethyldiphenyl diselenide) could be substrates of rat brain TrxR. In the presence of partially purified rat brain TrxR, dipheny...

2011-01-01

423

Differential expression of farnesyl diphosphate synthase gene from Withania somnifera in different chemotypes and in response to elicitors

British Library Electronic Table of Contents (United Kingdom)

Withania somnifera (L.) Dunal (Family, Solanaceae), commonly known as Ashwagandha is one of the most valuable medicinal plants synthesizing large number of pharmacologically active secondary metabolites known as withanolides. Though the plant has been well characterized in terms of phytochemical profiles as well as pharmaceutical activities, not much is known about the genes responsible for biosynthesis of these compounds. In this study, we have characterized a gene encoding farnesyl diphosphate synthase (FPPS; EC 2.5.1.10), a key enzyme in the pathway of biosynthesis of isoprenoids, from W. somnifera. The full-length cDNA of Withania somnifera FPPS (WsFPPS) of 1,253?bps encodes a polypeptide of 343 amino acids. The amino acid sequence homology and phylogenetic analysis suggest that WsFPPS...

2011-01-01

424

Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-?B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

British Library Electronic Table of Contents (United Kingdom)

The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12?weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished ...

2008-01-01

425

Detailed chemical kinetic reaction mechanisms for primary reference fuels for diesel cetane number and spark-ignition octane number

British Library Electronic Table of Contents (United Kingdom)

A detailed chemical kinetic reaction mechanism is developed for primary reference fuel mixtures of n-hexadecane and 2,2,4,4,6,8,8-heptamethyl nonane for diesel cetane ratings. The mechanisms are constructed using existing rules for reaction pathways and rate expressions developed previously for the primary reference fuels for gasoline octane ratings, n-heptane and iso-octane. These reaction mechanisms are validated by comparisons between computed and experimental results for shock tube ignition and for oxidation under jet-stirred reactor conditions. The combined kinetic reaction mechanism contains the submechanisms for the primary reference fuels for diesel cetane ratings and submechanisms for the primary reference fuels for gasoline octane ratings, all in one integrated large kinetic reac...

2011-01-01

426

Detailed Chemical Kinetic Reaction Mechanisms for Incineration of Organophosphorus and Fluoro-Organophosphorus Compounds

Cytokine-induced impairment of short-chain fatty acid oxidation and viability in human colonic epithelial cells

A detailed chemical kinetic reaction mechanism is developed to describe incineration of the chemical warfare nerve agent sarin (GB), based on commonly used principles of bond additivity and hierarchical reaction mechanisms. The mechanism is based on previous kinetic models of organophosphorus compounds such as TMP, DMMP and DIMP that are often used as surrogates to predict incineration of GB. Kinetic models of the three surrogates and GB are then used to predict their consumption in a perfectly stirred reactor fueled by natural gas to simulate incineration of these chemicals. Computed results indicate that DIMP is the only one of these surrogates that adequately describes combustion of GB under comparable conditions. The kinetic pathways responsible for these differences in reactivity are identified and discussed. The most important reaction in GB and DIMP that makes them more reactive than TMP or DMMP is found to be a six-center molecular elimination reaction ...

2001-12-13

427

Comparative biochemistry of betaine biosynthesis and accumulation in diverse dicot families

Pro-inflammatory cytokines may directly influence the viability and metabolic function of colonic epithelial cells (CEC) as an early event in the development of inflammatory bowel disease. We report here that TNF-alpha+IFN-gamma induced a synergistic, concentration-dependent decline in butyrate oxidation, an essential energy supply, in HT-29 and DLD-1 cells. TNF-alpha+IFN-gamma induced a parallel profound decline in cell viability in HT-29 cells, but not in DLD-1 cells, where impairment of butyrate oxidation seemed to precede later occurrence of cell damage. TNF-alpha+INF-gamma induced CEC damage was independent on NO formation and involved the IFN-gamma signalling pathway as well as induction of apoptosis. If cytokines have similar effects in vivo, these may lead to energy deficiency and thus contribute to CEC damage and disturbance of the epithelial integrity.

2000-01-01

428

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

Salt stress elicits betaine accumulation to high levels in species from several diverse dicot families (Chenopodiaceae, Amaranthaceae, Convolvulaceae, Solanaceae, and Asteraceae). FAM-MS studies with deuterated precursors showed that species from all these families synthesize betaine from choline. Enzyme assays and immunotitration data showed that all accumulating species contained betaine aldehyde dehydrogenase (BADH) enzyme activity recognized by antibodies raised against purified BADH isolated from Spinacia oleracea. Immunoblotting indicated that the BADH monomer was in all cases of Mr {approx} 63,000. The similarity of BADH in the different species is consistent with a single evolutionary origin for the betaine pathway. This was supported by the presence in immunoblots of a cross-reacting band at Mr {approx} 63,000 in Magnolia x Soulangiana, a primitive angiosperm.

1989-04-01

429

British Library Electronic Table of Contents (United Kingdom)

Many aspects of cellular motility and mechanics are cyclic in nature such as the extension and retraction of lamellipodia or filopodia. Inherent to the cycles of extension and retraction that test the environment is the production of mechano-chemical signals that can alter long-term cell behavior, transcription patterns, and cell fate. We are just starting to define such cycles in several aspects of cell motility, including periodic contractions, integrin cycles of binding and release as well as the normal oscillations in motile activity. Cycles of local cell contraction and release are directly coupled to cycles of stressing and releasing extracellular contacts (matrix or cells) as well as cytoplasmic mechanotransducers. Stretching can alter external physical properties or sites exposed b...

2009-01-01

430

Canadian soil quality criteria for lead, copper, arsenic, cadmium and mercury

Beyond Acid Suppression: New Pharmacologic Approaches for Treatment of GERD

National soil quality criteria for the protection of ecological receptors, including livestock and wildlife, are currently under development in Canada. Based on an evaluation of direct soil contact and soil and food ingestion pathways for sensitive species, soil quality criteria for lead, copper, arsenic, cadmium and mercury for three land use categories have been derived. The draft values, in mg/kg soil, for agricultural, residential/parkland, commercial/industrial land uses are: mercury, 4, 4, 30; copper, 62, 62, 100; cadmium, 10, 10, 27; lead, 70, 250, 400; arsenic, 17, 17, 26. Critical data requirements in developing soil quality criteria are also reviewed.

1995-12-31

431

British Library Electronic Table of Contents (United Kingdom)

Proton pump inhibitors are highly successful in treating gastroesophageal reflux disease, but a significant proportion of patients have persistent symptoms from weakly or nonacidic reflux. Transient lower esophageal sphincter relaxation (TLESR) represents the dominant mechanism of gastroesophageal reflux and has therefore become the most intensely investigated therapeutic target. The triggering of TLESR involve the vagal pathways and the ?-aminobutyric type B (GABA(B)) and metabotropic glutamate type 5 (mGluR5) receptors. Baclofen is a GABA(B) receptor agonist that is effective in inhibiting TLESR and reducing the number of reflux episodes, but is associated with significant central nervous system (CNS) side effects. The newer GABA(B) agonists, such as AZD9343 and AZD3355, and mGluR5 antag...

2010-01-01

432

Atmospheric chemistry on Venus, Earth, and Mars: Main features and comparison

British Library Electronic Table of Contents (United Kingdom)

This paper deals with two common problems and then considers major aspects of chemistry in the atmospheres of Mars and Venus. (1) The atmospheres of the terrestrial planets have similar origins but different evolutionary pathways because of the different masses and distances to the Sun. Venus lost its water by hydrodynamic escape, Earth lost CO"2 that formed carbonates and is strongly affected by life, Mars lost water in the reaction with iron and then most of the atmosphere by the intense meteorite impacts. (2) In spite of the higher solar radiation on Venus, its thermospheric temperatures are similar to those on Mars because of the greater gravity acceleration and the higher production of O by photolysis of CO"2. O stimulates cooling by the emission at 15@mm in the collisions with CO"2. ...

2011-01-01

433

Antisense-mediated suppression of C-hordein biosynthesis in the barley grain results in correlated changes in the transcriptome, protein profile, and amino acid composition

British Library Electronic Table of Contents (United Kingdom)

Antisense- or RNAi-mediated suppression of the biosynthesis of nutritionally inferior storage proteins is a promising strategy for improving the amino acid profile of seeds. However, the potential pleiotropic effects of this on interconnected pathways and the agronomic quality traits need to be addressed. In the current study, a transcriptomic analysis of an antisense C-hordein line of barley was performed, using a grain-specific cDNA array. The C-hordein antisense line is characterized by marked changes in storage protein and amino acid profiles, while the seed weight is within the normal range and no external morphological irregularities were observed. The results of the transcriptome analysis showed excellent correlation with data on changes in the relative proportions of storage protei...

2007-01-01

434

Anomalous properties of the local dynamics in polymer glasses

Analysis by radio-gaschromatography of volatile aldehydes produced by the linoleic acid oxidation of soya- and oats-lipoxygenase

The emergence of nanoscience has increased the importance of experiments able to probe the very local structure of materials, especially for disordered and heterogeneous systems. This is technologically important; for example, the nanoscale structure of glassy polymers has a direct correlation with their macroscopic physical properties. We have discovered how a local, high frequency dynamic process can be used to monitor and even predict macroscopic behavior in glassy polymers. Polyvinylethylenes vitrified by different chemical and thermodynamic pathways exhibit different densities in the glassy state. We find that the rate and amplitude of a high frequency relaxation mode (the Johari-Goldstein process involving local motion of segments of the chain backbone) can either correlate or anti-correlate with the density. This implies that neither the unoccupied (free) volume nor the configurational entropy governs the local dynamics in any general sense. Rather it is the ...

2008-01-01

435

Agriculture as a source of phosphorus for eutrophication in southern Europe

Soya- and oats-lipoxygenase (E.C. 1.13.1.13) are incubated by "1"4C-marked linoleic acid. The volatile aldehydes arising thereby are isolated. The activity of the components separated by gaschromatography is written down by a printing indicator and the impulses/min are registered and printed out by a ratemeter. Thus the aldehydes which are produced by the enzymatic oxydation with lipoxygenase from the molecule of the linoleic acid can be determined. The composition of the mixture of aldehydes is calculated in mol-% from the measured impulses for peak. A possible origin of pathway is indicated for the main reaction products hexanal (soyalipoxygenase) and non-trans-2-enal (oats-lipoxygenase). (orig.).

436

British Library Electronic Table of Contents (United Kingdom)

Abstract Large areas of the southern European countries possess a Mediterranean climate, which influences soil properties, land use, fertilizer application practices and pathways of phosphorus (P) loss from agricultural soils. On average, inputs of fertilizer P exceed P exports from the agricultural areas in these countries; however, large differences in P surplus/deficit and soil P test values exist among regions. Losses of P in drainage water are modest except in some irrigated areas and in those regions where intensive animal production is concentrated. Losses of P in runoff water, whether as dissolved reactive or particulate P, can be substantial as a result of the significance of erosive processes under the land uses typical of the Mediterranean region, where extreme rainfall events c...

2007-01-01

437

Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root

British Library Electronic Table of Contents (United Kingdom)

Glycyrrhiza glabra root is one of the common traditional Chinese medicines and used as flavoring and sweetening agents for tobaccos, chewing gums, candies, toothpaste and beverages. While glycyrrhizin is one of the main components in the extract of G. glabra root and has been characterized, the other components have not been well characterized. The mechanism of growth activation of breast cancer MCF-7 cells, including the activation of Erk1/2 and Akt, and the transcriptional regulation of estrogen-responsive genes, was examined by means of sulforhodamine B, luciferase reporter gene, real-time RT-PCR and Western blotting assays after the induction of the cells with the extract of G. glabra root. The extract has similar activity to that induced by 17b-estradiol (E2), although glycyrrhizin di...

2007-01-01

438

APC and KRAS mutations in distal colorectal polyps are related to smoking habits in men: results of a cross-sectional study

British Library Electronic Table of Contents (United Kingdom)

Background The purpose of this study was (a) to evaluate the association between cigarette smoking and the prevalence of distal colorectal polyps and adenocarcinoma and (b) to analyse genetic alterations representing different molecular pathways of the colorectal carcinogenesis. Methods A total of 623 asymptomatic male (mean age: 53 years; 50?65) car factory workers were included. Information on smoking habits and other lifestyle factors were collected followed by a 60 cm colonoscopy. APC and KRAS mutations and microsatellite status were determined in colorectal lesions (colorectal carcinoma (CRC), hyperplastic (HP) and adenomatous polyps (AP)). Data were analysed using unconditional multiple logistic regression models. Results Smokers had a higher prevalence of AP (OR 2.1; 95% CI 1.2?3.6;...

2011-01-01

439

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in a-synuclein transgenic C. elegans

British Library Electronic Table of Contents (United Kingdom)

Mutations or multiplications in a-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of wild-type a-synuclein as LB occurs as a hallmark lesion of these disorders, collectively referred to as synucleinopathies, implicating a-synuclein in the pathogenesis of synucleinopathy. To identify modifier genes of a-synuclein-induced neurotoxicity, we conducted an RNAi screen in transgenic C. elegans (Tg worms) that overexpress human a-synuclein in a pan-neuronal manner. To enhance the RNAi effect in neurons, we crossed a-synuclein Tg worms with an RNAi-enhanced mutant eri-1 strain. We tested RNAi of 1673 genes related to nervous system or synaptic functions, and identified 10 genes that, upon knockdown, caused severe growth/motor abnormalit...

2008-01-01

440

A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma

British Library Electronic Table of Contents (United Kingdom)

Hepatocellular carcinoma (HCC) represents a major health problem as it afflicts an increasing number of patients worldwide. Albeit most of the risk factors for HCC are known, this is a deadly syndrome with a life expectancy at the time of diagnosis of less than 1?year. Definition of the molecular principles governing the neoplastic transformation of the liver is an urgent need to facilitate the clinical management of patients, based on innovative methods to detect the disease in its early stages and on more efficient therapies. In the present study, we have combined the analysis of a murine model and human samples of HCC to identify genes differentially expressed early in the process of hepatocarcinogenesis, using a microarray-based approach. Expression of 190 genes was impaired in murine ...

2011-01-01

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441

A novel accelerated oxidative stability screening method for pharmaceutical solids

British Library Electronic Table of Contents (United Kingdom)

Abstract Despite the fact that oxidation is the second most frequent degradation pathway for pharmaceuticals, means of evaluating the oxidative stability of pharmaceutical solids, especially effective stress testing, are still lacking. This paper describes a novel experimental method for peroxide-mediated oxidative stress testing on pharmaceutical solids. The method utilizes urea-hydrogen peroxide, a molecular complex that undergoes solid-state decomposition and releases hydrogen peroxide vapor at elevated temperatures (e.g., 30C), as a source of peroxide. The experimental setting for this method is simple, convenient, and can be operated routinely in most laboratories. The fundamental parameter of the system, that is, hydrogen peroxide vapor pressure, was determined using a modified spect...

2011-01-01

442

\\title{Test Results from Quality Control Measurements of Phototubes for the CMS-CASTOR Calorimeter}

Vortex control of safety enclosures

\\end{abstract}

2008-01-01

443

Vibration tests on nuclear power station stacks equipped with structural control oil dampers

The vortex amplifier controller has no moving parts and therefore it can have extremely high reliability and avoid the maintenance problems associated with contaminated equipment. The vortex amplifier and its application to ventilation control of radioactive enclosures is described. Reverse purge vortex amplifier ventilation system control is also discussed. (U.K.).

444

Temperature and vital effect controls on Bamboo coral (Isididae) isotopegeochemistry: A test of the "lines method"

No abstract prepared.

2009-07-01

445

Stabilization Control of line of sight of OTM(On-The-Move) Antenna

Abstract not provided

2011-03-01

446

Situation with Rabies in the Republic of Tajikistan

Full Text Available

2010-11-01

447

Randomised Controlled Trial PFC Versus CKS Total Knee Prostheses

Assessment of the Situation with Rabies in the Republic of Tajikistan and Organization of Activities on Rabies Control

448

ROBUST CONTROL FOR 4WS VEHICLES CONSIDERING A VARYING TIRE-ROAD FRICTION COEFFICIENT

Osteoarthritis, Knee

2007-08-08

449

Quality Assurance in Safeguards: Indonesian Document Control and Records Management System

Full Text Available

2010-02-01

450

Protein-protein interactions and structural analysis of citrus proteins involved in transcriptional control during citrus canker disease

No abstract prepared.

2010-07-01

451

Predicting results of mycobacterial culture on sputum smear reversion after anti-tuberculous treatment: a case control study.

No abstract prepared.

2010-07-01

452

Periodic optimal control with application to pumped storage plants

PMID:20205743

2010-03-06

453

Performance of MIMO-OFDM systems combing Pre-FFT beamformer with power control algorithm

This paper suggests how nonlinear periodic optimal control of a pumped storage plant can be realized. The control problem consists in maximization of the plant benefits over an operational period. An optimal control law is proposed, yielding a bang-off-bang mode of operation. An algorithm for numerical solution of the problem was developed, and its effectiveness was demonstrated by simulation experiments.

1987-04-01

454

Passive Control of the Condensation Shock Wave Using Bleed Slots

Full Text Available

2009-01-01

455

Optimal Design of a Linear Structural Control System Considering Loading Uncertainties

Full Text Available

2002-07-01

456

New paradigm : controlling initiation phase is necessary for optimization of wire-array z-pinch performance.

Full Text Available

2011-04-01

457

Network Security Situation Awareness Adaptive Control Model Based on Cognitive Network

No abstract prepared.

2008-08-01

458

Multi-state control strategy of starting for a wet friction clutch via a fuzzy logic algorithm

Not Available

2010-06-01

459

Mobile laboratory for controlling and monitoring atmospheric pollution

Full Text Available

460

Instrumentation and Controls Division biennial progress report, September 1, 1978-September 1, 1980

Short communication. 1 ref., 4 figs.

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461

Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions

Brief summaries of research work are presented in the following section: overview of the ORNL Instrumentation and Controls Division activities; new developments and methods; reactor instrumentation and controls; measurement and control engineering; electronic engineering; maintenance; studies; services; and development; and division achievements.

1981-06-01

462

Implementation and laboratory test results for an adaptive Power System Stabilizer based on linear optimal control

Full Text Available

2011-08-01

463

Flow deflector for nuclear fuel element assemblies

Implementation of an adaptive power system stabilizer (PSS) based on linear optimal control is described in this paper. The generator is identified in real time, and a special 3rd order discrete Riccati equation is solved in each sample interval. Because the output of the generator is fed back directly, the controller can track the system very fast. Experimental studies on a physical model of a power system demonstrate the effectiveness of the proposed adaptive optimal controller.

1990-12-01

464

Flow Analysis and Modeling of Field-Controllable, Electro- and Magneto-Rheological Fluid Dampers

... coolants departure nucleate boiling fluid flow fluidic control devices fuel

465

Evaluation of Flood Control Capacity for Seongju Dam against Extreme Floods

Not Available

2007-01-01

466

Environmental Control for Precision Machining.

Full Text Available

2003-11-01

467

Emissions from coal fired boilers and efforts to reduce them

For abstract, see NSA 27 06, number 14465.

1972-01-01

468

Electromagnetic fluid valve

This paper reviews emission standards, technologies to control emissions, and the cost of these controls. It is concluded that international bodies will increasingly set minimum emissions, these standards will continue to be reduced, and in addition new substances will be controlled. The cost of this control will likely not exceed 0.5 cents per kWe-hr. 4 refs., 3 tabs.

1997-07-01

469

Effect of COY(Cooking Oil and Yolk Mixture) on Control of Tetranychus urticae

... bypasses control rod drives cylinders electromagnetic pumps fluid flow fluidic

470

ENHANCED CONTROL OF MERCURY BY WET FLUE GAS DESULFURIZATION SYSTEMS - SITE 1 RESULTS

Full Text Available

2008-09-01

471

EMC Performance Improvement of Distribution Automation Circuit-Breaker by Modified Installing Method of Control Cable

No abstract prepared.

1999-05-01

472

Dynamic performance testing of control valves

Full Text Available

2003-09-01

473

Drive control algorithm for an independent 8 in-wheel motor drive vehicle

Response of control valves plays an important role in the dynamics of the flow system as a whole. Knowledge of its transfer function would facilitate analysis of the behaviour of the system. This paper presents the application of Levy's complex curve fitting method for determination of the transfer function of control valves used in Liquid Zone Control System of 540 MWe PHWR. (author)

2005-02-01

474

Development of Small-sized Gas Turbine Engine Control System for Power Generation

Full Text Available

2011-06-01

475

Design of a Controller for the Heat Capacity of Thermal Storage Systems Using Off-Peak Electricity

Full Text Available

2011-08-01

476

Design of Friction Dampers for Seismic Response Control of a SDOF Building

Full Text Available

2001-01-01

477

Design of Control System for Hydraulic Cylinders of a Sluice Gate Using Fuzzy PI Algorithm

Full Text Available

2010-01-01

478

Control of a resonant d.c.-link converter for a.c. motor drives

Full Text Available

2010-02-01

479

Control of Heat Temperature in Light Emitting Diodes with Thermoelectric Device

Full Text Available

480

Control of Bakanae Disease of Rice by Seed Soaking into the Mixed Solution of Procholraz and Fludioxnil

Full Text Available

2011-07-01

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481

Control Efficacy of Bordeaux Mixture against Powdery Mildew on Omija (Schizandra chinensis)

Full Text Available

2009-08-01

482

Continuous control of ionization wave chaos by spatially derived feedback signals

Full Text Available

2009-02-01

483

Computer analysis and control for nondestructive gamma scanning of LMFBR fuel pins

In the positive column of a neon glow discharge, two different types of ionization waves occur simultaneously. The low-dimensional chaos arising from the nonlinear interaction between the two waves is controlled by a continuous feedback technique. The control strategy is derived from the time-delayed autosynchronization method. Two spatially displaced points of observation are used to obtain the control information, using the propagation characteristics of the chaotic wave.

1997-01-01

484

Biological Control of Sclerotinia sclerotiorum Using Indigenous Chitinolytic Actinomycetes in Jordan

A program to modernize existing computer control and data analysis in a precision gamma-scanning system is described. This involves interfacing a new computer-based multichannel analyzer to existing equipment through a CAMAC system with an intelligent crate controller and writing software for scan control and data reduction. Both hardware and software requirements are discussed. 6 figures.

485

BARNES ENGINEERING COMPANY

Full Text Available

2006-06-01

486

Application of impulse damper in control of a chaotic friction-induced vibration

... INFRARED THERMOMETERS AND TEMPERATURE CONTROLLERS--A POCKET-SIZE, PORTABLE INFRARED THERMOMETER, AND A ...

487

Application of Continuous Stirred Tank Reactor Model for Water Quality Control and Management in Wetland Treatment

Full Text Available

2011-02-01

488

Aggressiveness of Three Snow Mold Fungi on Creeping Bentgrass Cultivars under Controlled Environment Conditions

Full Text Available

2008-03-01

489

A multi-micro-computer based dual-rate self-tuning power system stabilizer

Full Text Available

2009-03-01

490

A Study on the Robust Control of Horizontal-Shaft Magnetic Bearing System Considering Perturbation

A dual-rate self-tuning control technique, in which the system identification and control calculation are performed separately, is proposed in this paper. This greatly increases the control rate. A self-tuning power system stabilizer (DSPSS) making use of this technique is developed and implemented using multi-micro-computers. Simulation and experimental results with DSPSS show that the increase in the control rate can considerably improve the system performance.

1987-09-01

491

A Numerical Study on a Circulation Control Foil using Coanda Effect

Full Text Available

2010-01-01

492

Full Text Available

2000-05-01

493

Tools and methods for implementing the control systems on the Mirror Fusion Test Facility

Health surveillance program This article outlines the principal components of quality control of laboratory rodents.

1986-02-01

494

New NDT developments for the control of components in the FA3 EPR nuclear reactor at Flamanville; Nouveau developpement END pour le controle de composants de la tranche EPR de Flamanville (FA3)

Installation of the major hardware subsystems for MFTF is nearing completion. These subsystems include the Fusion Chamber System, the eighty KV Neutral Beam System, the Superconducting Magnet System, and the Personnel Safety System. The Local Controls group has undertaken a uniform aproach to implementing the control systems for all of these hardware subsystems. This approach has two major aspects: (1) to provide a stand-alone computer control system with a remote, portable terminal so that computer control can be provided at the site of the hardware for initial testing, (2) to provide hardware simulators so that the complicated MFTF computer control system can be tested independent of the hardware. The software and hardware tools which were developed to carry out this plan will be described. Our experiences with bringing up subsystems containing up to 900 separate channels of ...

1981-09-29

495

Development of linear flow rate control system for eccentric butter-fly valve

New Non Destructive Testing techniques are currently being developed for the inspection of two groups of components in the FA3 EPR nuclear reactor at Flamanville. The first group of components to be controlled is constituted by the welds of the (89) rod cluster control assemblies' containment; two control types are to be used: an ultrasonic technique (UT) evaluation from the outside of the flange-casing weld, and an ET control from the inside of the three other welds. The second group of components is formed by the 44 welded joints of the primary circuit, which will be inspected through ultrasonic testing. Details of the components, control devices and sensors are given and some test results are presented

2009-07-01

496

Design of sediment-control measures for small areas in surface coal mining. Draft report

Butter-fly valves are advantageous over gate, globe, plug, and ball valves in a variety of installations, particularly in the large sizes. The purpose of this project development of linear flow rate control system for eccentric butter-fly valve (intelligent butter-fly valve system). The intelligent butter-fly valve system consist of a valve body, micro controller. The micro controller consist of torque control system, pressure censor, worm and worm gear and communication line etc. The characteristics of intelligent butter-fly valve system as follows: Linear flow rate control function. Digital remote control function. guard function. Self-checking function. (author)

1999-12-01

497

Design of sediment-control measures for small areas in surface coal mining

The manual provides design information for four groups of sediment control structures and treatments which are suitable for use on small areas in surface coal mining. A detailed design procedure is given for each group which will estimate the total amount of settleable solids from a small area with a sediment control structure or treatment for a specific design storm. A procedure is also given for estimating the mean annual sediment yield from a small area. Information on design, installation, maintenance and cost is given for each sediment control measure. Methods for determining the maximum allowable area for each sediment control measure and for design of combined sediment control systems are presented. The design procedures contain numerous nomographs, graphs, and worksheets to facilitate the use of the design procedure. The sediment control measures, design ...

1982-04-01

498

Bioprocess control from a multivariate process trajectory.

The manual provides design information for four groups of sediment control structures and treatments which are suitable for use on small areas in surface coal mining. A detailed design procedure is given for each group which will estimate the total amount of settleable solids from a small area with a sediment control structure or treatment for a specific design storm. A procedure is also given for estimating the mean annual sediment yield from a small area. Information on design, installation, maintenance and cost is given for each sediment control measure. Methods for determining the maximum allowable area for each sediment control measure and for design of combined sediment control systems are presented. The design procedures contain numerous nomographs, graphs, and worksheets to facilitate the use of the design procedure. The sediment control measures, design ...

1982-08-01

499