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The purpose of this study was to compare 2 adaptive radiotherapy strategies with helical tomotherapy. A patient having mesothelioma with mediastinal nodes was treated using helical tomotherapy with pretreatment megavoltage CT (MVCT) imaging. Gross tumor volumes (GTVs) were outlined on every MVCT study. Two alternatives for adapting the treatment were investigated: (1) keeping the prescribed dose to the targets while reducing the dose to the OARs and (2) escalating the target dose while maintaining the original level of healthy tissue sparing. Intensity modulated radiotherapy (step-and-shoot IMRT) and 3D conformal radiotherapy (3DCRT) plans for the patient were generated and compared. The primary lesion and nodal mass regressed by 16.2% and 32.5%, respectively. Adapted GTVs and reduced plan...

UK PubMed Central (United Kingdom)

The aim of this study is to compare the dosimetry results that are obtained by using Convolution, Superposition and Fast Superposition algorithms in Conventional Radiotherapy, Three-Dimensional Conformal...Full Text Available

International Nuclear Information System (INIS)

Objective: To evaluate the effect of metallic stent combined with stereotactic conformal radiotherapy (SCRT) for hilar cholangiocarcinoma. Methods: Fifty-four patients with hilar cholangiocarcinoma were analyzed, including 31 treated with stent plus stereotactic conformal radiotherapy (combined group) and 23 with metallic stent alone (control group). Results: The mean survival time of combined group was 11.1 #+-# 4.6 months, compared with 5.1 #+-# 2.8 months of the control group, giving a significant difference between the two groups (P<0.01). Conclusion: The combination of metallic stent and stereotactic conformal radiotherapy is more effective than metallic stent alone for unresectable hilar cholangiocarcinoma. (authors)

International Nuclear Information System (INIS)

Conformal radiation therapy represents a considerable and attractive challenge in oncology. Its aim is mainly to improve local control by increasing the dose with an acceptable rate of complications. This work overviews the world literature on this subject. The technical and theoretical requirements are highlighted. These requirements include a precise definition of the target volume by digital imaging (essentially CT scan), but also clear view of the target volume and the organs at risk, a specific collimation of the beam, 3-D dose calculations, optimization procedures, and a rigid immobilization of the patient with verification of his position. Moreover, the clinical applications of conformal radiation therapy are reviewed and discussed. (authors). 80 refs., 1 tab.

International Nuclear Information System (INIS)

Computed tomography allows today to reconstruct three-dimensional (eD) images fram axial scans. The authors report their experience in cranio-facial pathology achived in two Departments of Radiology (University of Trieste, Italy and University of Standford, California). 3D images have been realized using two different softwares, one of which allows to reconstruct both soft tissue and bone structures. The application in maxillo-facial traumas, cranio-facial malformations and head tumours are disscussed. 3D images turned out to be very useful for the optimal visualization and for the spatial demostration of the lesion and have potential applications in cranio-facial surgery and radiotherapy.

International Nuclear Information System (INIS)

Despite high local control rate in Ewing's sarcoma the exact indication of radiation therapy is still controversial as well as the choice of the target volume and the optimal dose of radiation. The importance of the quality of radiotherapy has been stressed in recently published data and has shown a significant impact on long term local control with adequate radiation therapy. The dramatic improvement of precision allowed by the conformal therapy and three dimensional dosimetry allow to expect a decrease of late effects expected for second malignancies. However, late sequelae and radio-induced osteosarcoma still remain the major side effects after radiotherapy. The authors discuss the results of the main trials on Ewing's sarcoma on the choice of dose and target volume. Surgery is still the preferred choice for small tumors if the foreseen outcome is identical. (authors). 28 refs.

International Nuclear Information System (INIS)

A computer-assisted rotation and stationary conformation radiotherapy system with overrunning multileaf collimators has been developed. This system can produce any shape of target volume, including a number of target areas outside the axis of the rotation, regardless of the location of the axis at 360"0 rotation irradiation. In addition, by changing the dose rate and deleting a partial region within a field, multiple stationary irradiation can produce more homogeneous target volumes - thus avoiding excessive irradiation to critical organs - than the rotation technique. (orig.).

International Nuclear Information System (INIS)

Purpose: To determine if involved field radiation (IF) is equivalent to standard whole bone radiation (SF) in local tumor control; to establish patterns of failure following treatment; and to determine response, event-free survival (EFS), and overall survival rates from multidisciplinary therapy in Ewing's sarcoma. Methods and Materials: Between 1983 and 1988, 184 children with Ewing's sarcoma were enrolled onto Pediatric Oncology Group 8346 (POG 8346). A total of 178 (97%) met eligibility criteria; 6 had pathology other than Ewing's sarcoma. Induction chemotherapy of cyclophosphamide/doxorubicin (adriamycin )(C/A) x 12 weeks was followed by local treatment either surgery or radiation therapy and C/A, dactinomycin, and vincristine for 50 weeks. Resection was advised for patients with small primary tumors if accomplished without functional loss. Forty patients were randomized to receive SF, whole bone radiation to 39.6 Gy plus a 16.2 Gy boost (total 55.8 Gy) or IF to 55.8 Gy, and the ...

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The synthesis of [3, 3-D[sub 2

International Nuclear Information System (INIS)

A fast and accurate segmentation of organs at risk, such as the healthy colon, would be of benefit for planning of radiotherapy, in particular in an adaptive scenario. For the treatment of pelvic tumours, a great challenge is the segmentation of the most adjacent and sensitive parts of the gastrointestinal tract, the sigmoid and descending colon. We propose a semi-automated method to segment these bowel parts using the fast marching (FM) method. Standard 3D computed tomography (CT) image data obtained from routine radiotherapy planning were used. Our pre-processing steps distinguish the intestine, muscles and air from connective tissue. The core part of our method separates the sigmoid and descending colon from the muscles and other segments of the intestine. This is done by utilizing the ability of the FM method to compute a specified minimal energy functional integrated along a path, and thereby ...

International Nuclear Information System (INIS)

Purpose: An inverse treatment planning algorithm for tomotherapy is described. Methods and Materials: The algorithm iteratively computes a set of nonnegative beam intensity profiles that minimizes the least-squares residual dose defined in the target and selected normal tissue regions of interest. At each iteration the residual dose distribution is transformed into a set of residual beam profiles using an inversion method derived from filtered backprojection image reconstruction theory. These 'residual' profiles are used to correct the current beam profile estimates resulting in new profile estimates. Adaptive filtering is incorporated into the inversion model so that the gross structure of the dose distribution is optimized during initial iterations of the algorithm, and the fine structure corresponding to edges is obtained at later iterations. A three dimensional, kernel based, convolution/superposition dose model is used to compute dose during each iteration. Results: Two clinically ...

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Automatic segmentation of anatomical structures in medical images is a valuable tool for efficient computer-aided radiotherapy and surgery planning and an enabling technology for dynamic adaptive radiotherapy. This paper presents the design, algorithms and validation of new software for the automatic segmentation of CT images used for radiotherapy treatment planning. A coarse to fine approach is followed that consists of presegmentation, anatomic orientation and structure segmentation. No user input or a priori information about the image content is required. In presegmentation, the body outline, the bones and lung equivalent tissue are detected. Anatomic orientation recognizes the patient's position, orientation and gender and creates an elastic mapping of the slice positions to a reference scale. Structure segmentation is divided into localization, outlining and refinement, performed by procedures with implicit ...

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Development status of small direct injection diesel engine at Isuzu Motors Ltd. is reviewed. There is much difficulty in combustion optimization of small DI engines, due to small combustion chamber volume, large surface to volume ratio, wide engine speed range and so on. Novel ideas in the area of injection system, combustion chamber and induction swirl were tried to solve these problems and their effects are presented here. Our prototype DI engines which adopted some of these ideas has turned out to have better fuel economy by about 15 percent, 2 - 3 dB(A) higher noise level than IDI and almost the same power output performance as IDI. As to exhaust emissions, they have a possibility to conform to '86 California emission standards, in inertia weight classes up to 2625 LBS. The remaining problem areas are noise emission, durability of injection pump and cabin heater performance. These problems must be solved by ...

UK PubMed Central (United Kingdom)

The treatment of locally advanced rectal cancer including timing and dosage of radiotherapy, degree of sphincter preservation with neoadjuvant radiotherapy, and short and long term effects of radiotherapy...Full Text Available

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Purpose. We have tested a procedure of focal injection of the contrast medium Lipiodol as a fiducial marker for image-guided boost of the tumor in bladder cancer radiotherapy (RT). In this study, we have evaluated the feasibility and the safety of the method as well as the inter- and intra-fraction shift of the bladder tumor. Materials and methods. Five patients with muscle invasive urinary bladder cancer were included in the study. Lipiodol was injected during flexible cystoscopy into the submucosa of the bladder wall at the periphery of the tumor or the post resection tumor-bed. Cone-beam CT (CBCT) scans were acquired daily throughout the course of RT. Results. Lipiodol demarcation of the bladder tumor was feasible and safe with only a minimum of side effects related to the procedure. The Lipiodol spots were visible on CT and CBCT scans for the duration of the RT course. More than half of all the treatment fractions required a geometric shift of 5 mm or more to ...

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Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT ...

International Nuclear Information System (INIS)

Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose ...

Medline Plus

... stenosis. It looks from the transesophageal and the 3-D echo that most of the problem is really ... posterior leaflet, which you can see on the 3-D echo image is a major source. The anterior ...

British Library Electronic Table of Contents (United Kingdom)

In order to reduce the number of surface mining accidents related to low visibility conditions and blind spots of trucks and to provide 3D information for truck drivers and real time monitored truck information for the remote dispatcher, a 3D assisted driving system (3D-ADS) based on the GPS, mesh-wireless networks and the Google-Earth engine as the graphic interface and mine-mapping server, was developed at Virginia Tech. The research results indicate that this 3D-ADS system has the potential to increase reliability and reduce uncertainty in open pit mining operations by customizing the local 3D digital mining map, constructing 3D truck models, tracking vehicles in real time using a 3D interface ...

Energy Technology Data Exchange (ETDEWEB)

Parallel imaging and echo sharing techniques have markedly reduced the acquisition times for MRI of large volumes. Dynamic 2 and 3-dimensional data sets of the chest with high temporal resolution (up to 10 images/s with single slice and 2 volume/s) allow an analysis of respiratory motion of the lungs and tumors. Time-resolved 2D series in preselected planes can be used to observe respiratory motion during free breathing or after respiratory commands, e.g. to exclude chest wall invasion by a tumor or for diagnosing impairment of respiratory mechanics. Time-resolved 3D-series (4D-MRI) allow monitoring of the spatial displacement of the lungs and tumors as a whole volume. Present limitations such as an overestimation of tumor size and an underestimation of displacement due to a limited temporal resolution are expected to be overcome with further technical developments. However, 4D-MRI already appears to be the appropriate tool to select patients ...

KoreaScience (Korea)

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KoreaScience (Korea)

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Medline Plus

... 2009) Arrhythmia Electrophysiological Study and Catheter Ablation with 3D Mapping (Mercy Hospital, Miami, FL, 11/15/2007) ...

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In this article, the author presents the principles, applications and advantages of proton and heavy ion beams used for radiotherapy.

CERN Document Server

Determination of absorbed dose in a patient irradiated by beams of x or gamma rays in radiotherapy procedures

International Nuclear Information System (INIS)

Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 (RTOG) acute and/or late tissue radiation side effects by reaction severity. DNA from the ...

Science.gov (United States)

... Accession Number : ADD344580. Title : SQUID Eddy Current Technique Applying Conformable Eddy Current Probes,. Corporate Author : ...

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Culex mosquitoes introduce the pathogens responsible for filariasis, West Nile virus, St. Louis encephalitis, and other diseases into humans. Currently, traps baited with oviposition semiochemicals play an important role in detection efforts and could provide an environmentally friendly approach to controlling their populations. The odorant binding proteins (OBPs) in the female's antenna play a crucial, if yet imperfectly understood, role in sensing oviposition cues. Here, we report the X-ray crystallography and NMR 3D structures of OBP1 for Culex quinquefasciatus (CquiOBP1) bound to an oviposition pheromone (5R,6S)-6-acetoxy-5-hexadecanolide (MOP). In both studies, CquiOBP1 had the same overall six-helix structure seen in other insect OBPs, but a detailed analysis revealed an important previously undescribed feature. There are two models for OBP-mediated signal transduction: (i) direct release of the pheromone from an internal binding ...

International Nuclear Information System (INIS)

The document reports the main issues discussed during the first course-debate on quality controls in radiotherapy, held in Rome in December 3-4, 1998 and May 3-5 1999 in collaboration between the Istituto Superiore di Sanita' and the Istituto Regina Elena. The points considered critical to the quality assurance in radiotherapy by the participants are presented in relation to the total radiotherapy procedure.

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No abstract prepared.

KoreaScience (Korea)

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British Library Electronic Table of Contents (United Kingdom)

Using institutional and resource dependence theories as the conceptual framework, this study identifies three forms of conformity?political, economic, and social?that can affect the level of private entrepreneurs? formal political participation in a transition economy. Data from a 2004 national-wide survey of 3,012 private firms in China show that political conformity (indicated by membership in the ruling party), economic conformity (amount of taxes paid), and social conformity (amount of charity donated) are each antecedents to private entrepreneurs? formal political participation. Moreover, political conformity negatively moderates the relationship between social conformity and private entrepreneurs? formal political participation?for party members, a lesser amount of charity is associa...

International Nuclear Information System (INIS)

Firstly the so called 'conformal relativity' in the 6-dimensional conformal space is formulated. In particular the concept of dilatational degree of freedom - scale - is introduced. The special conformal transformations are interpreted as the transformations connecting dilatationally moving frames (and objects). The ideas, similar to those by Kaluza and Klein, can be applied to the conformal space to obtain a unification of gravitation and electromagnetism. Lastly the conformal symmetry is extended to imaginary scales and to negative scales. Particles having imaginary scales are shown to be tachyons, whilst particles with negative scales correspond to antiparticles. (Auth.).

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Introduction: The goal of this study was to compare contrast-enhanced T1-weighted Flash and Turbo-Flash sequences with conventional spin-echo sequences as a basis for planning high-precision radiotherapy. Methods: A total of 25 consecutive patients with different intracranial tumors and a disrupted blood-brain barrier were studied. T1-weighted Flash, Turbo-Flash and conventional spin-echo images were evaluated after controlled 30-s infusion of 0.1 mmol/kg body weight of Gd-DTPA. The evaluation of the three sequences included the measurement of the signal- and contrast-to-noise ratios, the visual inspection of the tumors and artifacts, and the measurement of tumor size. Results: The signal- and contrast-to-noise ratios were significantly (P<0.05-0.01) lower for Flash and Turbo-Flash than for conventional spin-echo sequences. However, visual inspection of the contrast-enhancing tumors revealed in 23 and 24 of 25 lesions of Flash and Turbo-Flash images, ...

UK PubMed Central (United Kingdom)

BackgroundMany three-dimensional (3D) images are routinely collected in biomedical research and a number of digital atlases with associated anatomical and other information have...Full Text Available

Medline Plus

... catheter ablation for paroxysmal atrial fibrillation procedure utilizing 3-D mapping and rotational intracardiac echocardiography. This program is ... of the MRI scan and then there's the 3-D image, which is generated from the pixels chosen ...

UK PubMed Central (United Kingdom)

ObjectiveCompare occlusal contacts calculated from 3D virtual models created from clinical records to contacts identified clinically using shimstock and transillumination.Full Text Available

Medline Plus

... Exercises: Day and Night Classroom Exercises: Pinhole Focusing 3D Vision and Eye Health < Contact Lenses Monovision Playlist: ...

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... Exercises: Day and Night Classroom Exercises: Pinhole Focusing 3D Vision and Eye Health < Caring for Your Vision ...

Science.gov (United States)

The mixture of 1,3-dichloropropene (1,3-D) and chloropicrin (CP) is used as a preplant soil fumigant. In comparison with individual fumigants, application of a mixture may affect the environmental dissipation and fate of each chemical, such as emission and degradation. We investigated the degradation of CP, 1,3-D, and their mixture in fresh soils and sterile soils, and evaluated the competitive characteristic of fumigants in the mixture. The degradation of low concentrations of CP in fresh soil was accelerated at early times in the presence of 1,3-D, whereas the addition of CP reduced the degradation rate of trans-1,3-D, possibly by inhibiting the activity of trans-1,3-D degrading microorganisms. The potential of applying amendments to the soil to increase the rate of CP and ...

International Nuclear Information System (INIS)

3d occupation numbers of the transition elements corresponding to various types of atomic configurations are calculated by means of the linear muffin-tin orbital (LMTO) method. This data is used with the multiconfiguration Dirac-Fock (MCDF) X-ray intensity ratios to estimate the electron populations of the 3d metals in alloys.

International Nuclear Information System (INIS)

Background and purpose: Local treatment for non-metastatic Ewing's sarcoma family tumors (ESFTs) is controversial. Results achieved in a single institution in patients with ESFT of the humerus are presented. Materials and methods: Patients treated between 1983 and 2000 for ESFT of the humerus were included. The impact of local treatment (surgery, radiotherapy or both) on outcome was assessed. Results: 55 patients: 34 males (62%); 21 females (38%); mean age: 17.9 (range: 3-40). Local treatment: surgery in 27 patients (49%), radiotherapy in 17 (31%) and surgery followed by radiotherapy in 11 (20%). After a mean follow-up of 15 years (range: 7-25 years), 27 patients (49%) remained continuously disease free, 27 (49%) relapsed and one died of chemotherapy toxicity. The local recurrence rate was 13% overall: 18% (3/17) after radiotherapy, 7% (2/27) after surgery and 19% (2/11) after surgery followed by ...

CERN Document Server

Tolerancing of assembly mechanisms is a major interest in the product life cycle. One can distinguish several models with growing complexity, from 1-dimensional (1D) to 3-dimensional (3D) (including form deviations), and two main tolerancing assumptions, the worst case and the statistical hypothesis. This paper presents an approach to 3D statistical tolerancing using a new acceptance criterion. Our approach is based on the 1D inertial acceptance criterion that is extended to 3D and form acceptance. The modal characterisation is used to describe the form deviation of a geometry as the combination of elementary deviations (location, orientation and form). The proposed 3D statistical tolerancing is applied on a simple mechanism with lever arm. It is also compared to the traditional worst-case tolerancing using a tolerance ...

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Three-dimensional seismic wavefields may be extrapolated in depth, one frequency at a time, by two-dimensional convolution with a circularly symmetric, frequency- and velocity-dependent filter. This depth extrapolation, performed for each frequency independently, lies at the heart of 3-D finite-difference depth migration. The computational efficiency of 3-D depth migration depends directly on the efficiency of this depth extrapolation. McClellan transformations provide an efficient method for both designing and implementing two-dimensional digital filters that have a particular form of symmetry, such as the circularly symmetric depth extrapolation filters used in 3-D depth migration. Given the coefficients of one-dimensional, frequency- and velocity-dependent filters used to accomplish 2-D depth migration, McClellan transformations lead to a simple and efficient ...

UK PubMed Central (United Kingdom)

SummaryRadiotherapy is used commonly in the treatment of gynecologic malignancies. Many patients experience emotional distress prior to the initiation of radiotherapy, during...Full Text Available

UK PubMed Central (United Kingdom)

Intensity modulated radiotherapy (IMRT) is widely used in clinical applications in developed countries, for the treatment of malignant and non-malignant diseases. This technique uses multiple radiation...Full Text Available

UK PubMed Central (United Kingdom)

The offline adaptive radiotherapy (ART) has been used to effectively correct and compensate the prostate motion and reduce the required margin. The efficacy depends on the characteristics of...Full Text Available

UK PubMed Central (United Kingdom)

The conformation of d (CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix....Full Text Available

International Nuclear Information System (INIS)

Treatment of Ewing's sarcoma by radiotherapy, chemotherapy and surgery singly and in combination is reviewed.(M.G.B.).

International Nuclear Information System (INIS)

Background and purpose: The low density of lung tissue causes a reduced attenuation of photons and an increased range of secondary electrons, which is inaccurately predicted by the algorithms incorporated in some commonly available treatment planning systems (TPSs). This study evaluates the differences in dose in normal lung tissue computed using a simple and a more correct algorithm. We also studied the consequences of these differences on the dose-effect relations for radiation-induced lung injury. Materials and methods: The treatment plans of 68 lung cancer patients initially produced in a TPS using a calculation model that incorporates the equivalent-pathlength (EPL) inhomogeneity-correction algorithm, were recalculated in a TPS with the convolution-superposition (CS) algorithm. The higher accuracy of the CS algorithm is well-established. Dose distributions in lung were compared using isodoses, dose-volume histograms (DVHs), the mean lung dose (MLD) and the percentage of lung ...

Science.gov (United States)

The thermodynamic characteristics of adsorption on the surface of graphitized thermal carbon black at 300 K were determined by the molecular statistical method for three phenylalklylamines. The influence of the intramolecular H-bond on the conformation of the molecules compared with structurally related n-alkyl-benzenes was considered. It was shown that the conformations of the molecules could influence chromatographic retention. Conformational isomers stabilized by intramolecular H-bonds were found to retain their structure in adsorption on graphitized thermal carbon black.

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Evaluation and interpretation of CT colonography is based on both 2D and 3D techniques. The 2D techniques are popular mainly because the time needed for evaluation is short. The 3D techniques allow better definition than the 2D techniques, especially of polyps close to folds or at the base of a fold. The evaluation strategies generally accepted so far (primarily 2D, with 3D for problem cases, or vice versa) demand knowledge of both 2D and 3D techniques. Newer 3D visualization techniques help make it possible to acquire more complete and faster recording particularly of areas that are not easily accessible to endoscopic examination. These user-friendly developments are thus well suited to improving the detection and the security of detection of polyps. It must be remembered that ...

International Nuclear Information System (INIS)

In interventional radiology (IVR) of cerebral aneurysms, it is important to understand the form and physical relationships between the cerebral aneurysm and the surrounding vessels. However, because the vessels in the head area are highly complex, it can be difficult to comprehend the structure using conventional angiography. Therefore, three-dimensional rotational angiography (3D-RA) has been used in recent years. This article discusses studies of the spatial resolution of 3D-RA. We reconstructed 3D-RA of an acrylic slit phantom (slit widths: 0.5, 0.75, 1.0, 1.5 mm) and examined spatial resolution by visual evaluation and profile curves. When the slit phantom was arranged to avoid the effect of beam hardening, the spatial resolution of 3D-RA was found to be as high as 0.75 mm. When the slit phantom was placed orthogonal ...

Energy Technology Data Exchange (ETDEWEB)

In the construction work for the Unit No.5 Turbine Building at Hamaoka Nuclear Power Station, the collaboration work for the planning and the coordination of the building construction and the machinery installation was carried out utilizing three-dimensional computer aided design (3D CAD) information. It was the first time in Japan for a building constructor and a plant manufacturer to work together, exchanging 3D CAD data of the whole building and adjusting the construction schedule. It was made possible to confirm the correspondence concerning the planning of both companies from the primary stage of the project by the total process simulation and to adjust on-going work precisely by the partial process simulation.

Science.gov (United States)

... and/or hearing mechanisms. Seven papers dealt with 3D audio technology and/or its application. Eight papers presented ...

Science.gov (United States)

Guidelines for the viability primer component of the version 3 workbook. The Viability page in the current version of the Excel spreadsheet for conservation ... ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

... applications related to military and intelligence area ... the technology solved yet, but the open issue still ... fields, columns; ie data source, document type ...

International Nuclear Information System (INIS)

The authors have been developing a 3D brain CT image display system for planning of craniofacial operations. This system helps doctors plan craniofacial operations on a graphic display (GD) terminal by rendering 3D images reconstructed from a set of slices. The authors reveal how the system generates 3D shapes of organs from given CT images and how it modifies or transforms the obtained shapes according to the user's request. The system functions now available are extraction and display of the skull and the skin, measurement of the distance between two points on the skull given through the GD terminal, and generating and eliminating a polygonal region arbitrarily given on the skull as an operative region. (Auth.).

Science.gov (United States)

Bone is a complex, highly structured, mechanically active, three-dimensional (3-D) tissue composed of cellular and matrix elements. We previously published a report on in situ collagen gelation using a rotary 3-D culture system (CG-RC system) for the construction of large tissue specimens. The objective of the current study was to evaluate the feasibility of bone tissue engineering using our CG-RC system. Osteoblasts from the calvaria of newborn Wistar rats were cultured in the CG-RC system for up to 3 wk. The engineered 3-D tissues were implanted into the backs of nude mice and calvarial round bone defects in Wistar rats. Cell metabolic activity, mineralization, and bone-related proteins were measured in vitro in the engineered 3-D tissues. Also, the in vivo histological features of the transplanted, engineered ...

International Nuclear Information System (INIS)

1 - Description of program or function: T-HEMP3D (Transportable HEMP3D) is a derivative of the STEALTH three-dimensional thermodynamics code developed by Science Applications, Inc. Changes were made primarily in three areas: material specification, coordinate generation, and the addition of sliding surface boundary conditions. STEALTH itself is based entirely on the HEMP3D code written at LLNL. HEMP3D solves problems in solid mechanics involving dynamic plasticity and time-dependent material behavior and problems in gas dynamics. 2 - Method of solution: The equations of motion, conservation equations, and constitutive relations for stresses, strains, hydrostatic pressure, the von Mises yield condition, and artificial viscosity are solved by finite difference methods following the format of the HEMP code (NESC Abstract ...

Science.gov (United States)

The achievement of inner-shell photoionization of Zn-like Pd by means of two exploding foils is described. This resulted in the soft X-ray transition 3d94s2-3d104p at 46 A. It is shown that the photoionization of inner shell electrons in highly stripped ions can lead to X-ray transitions which may be candidates for X-ray lasers under 50 A.

International Nuclear Information System (INIS)

Our studies on K#beta#/K#alpha# X-ray intensity ratios of some of the technologically important 3d-transition metal compounds have been reviewed. Comparison of the experimental results with single-configuration Dirac-Fock calculations provided important information on the valence states of the transition metals in various compounds, which can be helpful in understanding the nature of bonding in the compounds. (author)

Energy Technology Data Exchange (ETDEWEB)

Chemical influences on the relative Ksub(..beta..)/Ksub(..cap alpha..) x-ray intensity ratio up to five per cent were found for different chemical constitutions of Cr, Mn, Fe and Cu by very precise PIXE measurements. In the discussion of these effects, screening of 3p electrons by a varying 3d valence charge, as well as polarizational effects are of importance.

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Development of a number of original 3-D migration methods and algorithms is described. The computational efficiency of these algorithms is demonstrated by implementing them on vector and parallel supercomputers. Two-dimensional post-stack and pre-stack depth migration algorithms in the frequency - space domain using implicit finite difference method were also developed and implemented on a parallel computer, and adapted for applications that range from deep crustal imaging of seismic wavefields that involve wide ranging travel times and frequencies. All implicit finite difference migration algorithms were highly prallelized . The one pass 3-D post-stack depth migration algorithm was extensively used for imaging of seismic monitoring data from Cold Lake, Alberta. Experience shows that it provides the right trade-off between accuracy and computational efficiency. A new formulation of the ...

Energy Technology Data Exchange (ETDEWEB)

We have studied the nucleation and growth processes in a chemical vapor deposition (CVD) diamond film using a tomographic electron backscattering diffraction method (3D EBSD). The approach is based on the combination of a focused ion beam (FIB) unit for serial sectioning in conjunction with high-resolution EBSD. Individual diamond grains were investigated in 3-dimensions particularly with regard to the role of twinning.

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Contributions to the population dose due to medical applications of ionising radiation are presented. It appears that contributions due to radiotherapy and X ray diagnosis are of comparable magnitude. To account for the age dependency of the radiation risks, contributions in terms of somatically significant dose equivalent are calculated as 0.3 mSv per caput per annum for X ray diagnosis and as 0.2 mSv per caput per annum for radiotherapy, the latter referring to only doses to organs outside the target volume. (author).

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Faults are being actively investigated across Japan since the Great Hanshin-Awaji Earthquake. Discussed in this report is the application of the 3D near-surface reflection seismic survey in big cities. Data from trenching and drilling is used for the geological interpretation of the surroundings of a fault, and the reflection seismic survey is used to identify the position, etc., of the fault. In this article, when the results obtained from the experimental field are examined, it is found that the conventional 2D imaging reflection survey betrays the limit of its capability when the geological structure is complicated, that the 3D reflection seismic survey, on the contrary, is capable of high-precision imaging and, when augmented by drilling, etc., becomes capable of a more detailed interpretation, and that it also contributes effectively to the improvement of local disaster prevention in big cities. ...

CERN Document Server

It has been proposed that a hidden conformal field theory (CFT) governs the dynamics of low frequency scattering in a general Kerr black hole background. We further investigate this correspondence by mapping higher order corrections to the massless wave equations in a Kerr background to an expansion within the CFT in terms of higher dimension operators. This implies the presence of infinite towers of CFT primary operators with positive conformal dimensions compatible with unitarity. The exact Kerr background softly breaks the conformal symmetry and the scaling dimensions of these operators run with frequency. The scale-invariant fixed point is dual to a degenerate case of flat spacetime.

International Nuclear Information System (INIS)

Purpose: To conduct a retrospective analysis within a large university teaching hospital, comparing outcomes between patients receiving either radical surgery or radiotherapy as curative treatment for bladder cancer. Patients and Methods: Between March 1996 and December 2000, 169 patients were treated radically for muscle-invasive bladder cancer. Data were collected from patient notes. Statistical analyses were performed using Kaplan-Meier methods and Cox proportional hazards regression analysis to compare radiotherapy and surgical outcome data. Results: There was no difference in overall, cause-specific, and distant recurrence-free survival at 5 years between the two groups, despite the radiotherapy group being older (median age, 75.3 years vs. 68.2 years). There were 31 local bladder recurrences in the radiotherapy group (24 solitary), but there was no significant difference in distant recurrence-free ...

British Library Electronic Table of Contents (United Kingdom)

The initial management of nonfunctioning pituitary macroadenomas (NFAs) is usually surgery; however, a significant proportion of NFAs may require further treatment. Radiotherapy is currently used in patients with residual tumour and achieves excellent long-term control, but there are concerns about potential late toxicity. Stereotactic radiotherapy, both in the form of radiosurgery or fractionated stereotactic radiotherapy, has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. A review of the literature suggests that new radiation techniques offer safe and effective treatment for recurrent or residual pituitary adenomas; how...

British Library Electronic Table of Contents (United Kingdom)

ObjectivesTo assess the influence of epigallocatechin-3-gallate (EGCG) on the efficacy of ionizing radiation on prostate cancer cells because of the increased use of dietary interventions, especially by patients with prostate cancer. Radiotherapy is used to treat localized prostate cancer. Some people consume green tea (EGCG) as a chemopreventive agent against prostate cancer. Green tea can act as an antioxidant and induce superoxide dismutase enzymes, which could scavenge the free oxygen radicals generated by radiotherapy. MethodsProstate cancer cell line DU145 cells were treated with EGCG or radiotherapy, or both. Cell death was assessed using trypan blue cell counting, and apoptosis was confirmed by assessing poly (adenosine phosphate ribose) polymerase cleavage. The antioxidant potenti...

UK PubMed Central (United Kingdom)

Previous research with individuals undergoing surgery or diagnostic procedures provided a conceptual framework for analysis of radiation therapy, a common form of cancer treatment. The present...Full Text Available

International Nuclear Information System (INIS)

The objective of this study was to explore the role of three-dimensional (3-D) rotational angiography (RA) of the inferior vena cava (IVC; 3-D CV) before filter retrieval and its impact on treatment planning compared with standard anteroposterior cavography (sCV). Thirty patients underwent sCV and 3-D CV before IVC filter retrieval. Parameters assessed were: projection of filter arms or legs beyond the caval lumen, thrombus burden within the filter and IVC, and orientation of the filter within IVC. Skin and effective radiation doses were calculated. Statistical analysis was performed using paired Student t test and nonparametric McNemar's test. Standard anteroposterior cavography detected 49 filter arms or legs projecting beyond the caval lumen in 25 patients. Three-dimensional CV demonstrated 89 filter arms or legs projecting beyond the caval lumen in 28 ...

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The effect of counter-ion species on the local conformation of fully-charged poly(L-glutamate) in added-salt aqueous solutions were studied by small-angle X-ray scattering(SAXS). In the case of presence of monovalent counter-ion, the scattering behaviour could be explained by taking into consideration the excluded volume effect and intermolecular-interface interaction on the scattering function of wormlike chain. On the other hand, since SAXS profile of the solution in the presence of divalent counter-ion well fitted to the scattering function of dendrimer, it suggested that the conformation of polymer chain in such solution would be more compact conformation than that of presence of monovalent ion.

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This document is a user`s manual for the Rn3D finite element code. Rn3D was developed to simulate gas flow and radon transport in variably saturated, nonisothermal porous media. The Rn3D model is applicable to a wide range of problems involving radon transport in soil because it can simulate either steady-state or transient flow and transport in one-, two- or three-dimensions (including radially symmetric two-dimensional problems). The porous materials may be heterogeneous and anisotropic. This manual describes all pertinent mathematics related to the governing, boundary, and constitutive equations of the model, as well as the development of the finite element equations used in the code. Instructions are given for constructing Rn3D input files and executing the code, as well as a description of all output files generated ...

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The aim of this study is three folds: to compare the eight-channel phased-array and standard circularly polarized (CP) head coils in visualiazation of the intracranial vessels, to compare the three-dimentional (3D) time-of-flight (TOF) MR angiography (MRA) techniques, and to define the effects of parallel imaging in 3D TOF MRA. Fifteen healthy volunteers underwent 3D TOF MRA of the intracranial vessels using eight-channel phased-array and CP standard head coils. The following MRA techniques were obtained on each volunteer: (1) conventional 3D TOF MRA with magnetization transfer; (2) 3D TOF MRA with water excitation for background suppression; and (3) low-dose (0.5 ml) gadolinium-enhanced 3D TOF MRA with water excitation. Results are ...

International Nuclear Information System (INIS)

Results of treatment of 30 children with Ewing's sarcoma irradiated in the First Radiotherapy Department, Cancer Center, Warsaw, in the period 1983-1992, are described. In 40% of patients NED survival from 1 till 10 years and in 70% the local control was obtained, and no serious radiations equelae were observed. (author).

UK PubMed Central (United Kingdom)

BackgroundThe purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial...Full Text Available

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This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

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Lysozyme chloride was administered to 84 patients of laryngeal cancer and the clinical effect was discussed. Lysozyme chloride delayed the appearance of swelling and white plaque while it accelerated that of inflammatory erythema in radiotherapy. No difference of the local inflammation was found between lysozyme administered groups and not administered groups when irradiation and chemotherapy were combined. Any side effect was not seen in blood picture of all cases by using lysozyme chloride.

International Nuclear Information System (INIS)

Present-day requirements for radiotherapy equipment are considered. The recently developed linacs of LUE-5, LUE-25, LUE-15MM models, as well as a newly designed unified series of medical linacs of LUER-5M, LUER-20M, LUER-40M models are described in brief. The main scientific and technical problems that were solved during their construction, namely, development of accelerating structures, a radiation head, dosimetry equipment, a programming unit, a magnetic mirror etc. are described.

British Library Electronic Table of Contents (United Kingdom)

Purpose Video-assisted thoracic surgery (VATS) has recently been adopted for complicated anatomical lung resections. During these thoracoscopic procedures, surgeons view the operative field on a two-dimensional (2-D) video monitor and cannot palpate the organ directly, thus frequently encountering anatomical difficulties. This study aimed to estimate the usefulness of preoperative three-dimensional (3-D) imaging of thoracic organs. Methods We compared the preoperative 64-row three-dimensional multidetector computed tomography (3DMDCT) findings of lung cancer-affected thoracic organs to the operative findings. Results In comparison to the operative findings, the branches of pulmonary arteries, veins, and bronchi were well defined in the 3D-MDCT images of 27 patients. Conclusion 3D-MDCT imag...

British Library Electronic Table of Contents (United Kingdom)

Summary Solid state nuclear track detectors are used to determine the concentration of a particles in the environment. The standard method for assessing exposed detectors involves 2D image analysis. However 3D imaging has the potential to provide additional information relating to angle as well as to differentiate clustered hit sequences and possibly energy of a particles but this could be time consuming. Here we describe a new method for rapid high-resolution 3D imaging of solid state nuclear track detectors. A `LEXT' OLS3100 confocal laser scanning microscope (Olympus Corporation, Tokyo, Japan) was used in confocal mode to successfully obtain 3D image data on four CR-39 plastic detectors. Three-dimensional visualization and image analysis enabled characterization of track features. This ...

International Nuclear Information System (INIS)

A three-dimensional (3D) thermal-hydraulic model and a numerical procedure for the simulation and analysis of a steady-state, as well as transient operation of nuclear power plant components are presented. A two-fluid approach is applied to modelling of two-phase flow. Thermal-hydraulics of a horizontal steam generator in the WWER 1000 nuclear power plant has been simulated at the full load, steady-state operation. A comparison of the numerical results with data measured at the NPP Novovoronjezh shows good agreement. 3D numerical results can be used in plant design or retrofitting, in nuclear power plant operation and safety analysis and as improvement of existing one-dimensional thermal-hydraulics models of the horizontal steam generator which are assessed by system codes used for the nuclear power plant safety analyses. (author)

UK PubMed Central (United Kingdom)

BackgroundThe pre-fusion form of the herpes simplex virus (HSV) fusion protein gB undergoes pH-triggered conformational change in vitro and during viral entry (Dollery...Full Text Available

UK PubMed Central (United Kingdom)

Conformational transitions of poly(dA-dC).poly(dG-dT), poly(dA-dT).poly(dA-dT), and other alternating purine-pyrimidine DNAs were studied in aqueous ethanol solutions containing molar concentrations...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTo compare two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated...Full Text Available

International Nuclear Information System (INIS)

By using linearized conformal transformations in six dimensions, a new unified approach to bradyons (v"2< c"2) and tachyons (v"2>c"2) is suggested, the essential tool being (real and imaginary) dilatations. The usual ''Generalized Lorentz transformations'' are got, In six dimensions the quadrate form is always positive, both for bradyons and for tachyons.

International Nuclear Information System (INIS)

Twenty-seven histologically confirmed cases of localised Ewing's sarcoma were treated by two different regimes. Radiotherapy alone was used in 13 cases and a combination of chemotherapy and radiotherapy in 14. Single agent chemotherapy (cyclophosphamide) was given sequentially in nine patients and cyclophosphamide and actinomycin-D in five. There is a significant difference in the response to these different regimes. Only 69.2% of patients treated by radiotherapy alone were disease-free, for a median period of 10.4 months and metastases were noticed in 53.8% of cases. The disease-free survival in patients treated by combination therapy (radiotherapy and chemotherapy) was 18.4 months and metastases were seen in only 42.9%. However, no metastases were seen in patients who received cyclophosphamide and actinomycin-D, during a period of 14 months and only one patient showed residual disease. It is concluded ...

Science.gov (United States)

Jun 10, 2011 ... Subsonic flow past a semi-infinite flat plate is modeled at Reynolds number 6 ..... data is taken from Cook, McDonald, and Firmin, AGARD-AR-138, 1979, p. ...... too large a time-averaged separation bubble behind the hump. ...

UK PubMed Central (United Kingdom)

A robust technique for determining the principal axes of a 3D shape represented by a point set, possibly with noise, is presented. We use techniques from robust statistics to guide the classical...Full Text Available

CERN Document Server

We propose the Particle Swarm Optimization (PSO) as an alternative method for locating periodic orbits in a three--dimensional (3D) model of barred galaxies. We develop an appropriate scheme that transforms the problem of finding periodic orbits into the problem of detecting global minimizers of a function, which is defined on the Poincar\\'{e} Surface of Section (PSS) of the Hamiltonian system. By combining the PSO method with deflection techniques, we succeeded in tracing systematically several periodic orbits of the system. The method succeeded in tracing the initial conditions of periodic orbits in cases where Newton iterative techniques had difficulties. In particular, we found families of 2D and 3D periodic orbits associated with the inner 8:1 to 12:1 resonances, between the radial 4:1 and corotation resonances of our 3D Ferrers bar model. The main ...

UK PubMed Central (United Kingdom)

There has been a controversy as to whether or not the non-pathological flat foot and high-arched foot have an effect on human walking activities. The 3D foot scanning system was employed to obtain static...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Metacad is a collection of routines which creates a randomly accessible data structure from Applicon's APPLE-3D data format and supplies a logical method for manipulation of the data structure by a CAD application program.

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Experiments are performed to investigate the single-phase flow and flow-boiling heat transfer augmentation in 3D internally finned and micro-finned helical tubes. The tests for single-phase flow heat transfer augmentation are carried out in helical tubes with a curvature of 0.0663 and a length of 1.15 m, and the examined range of the Reynolds number varies from 1000 to 8500. Within the applied range of Reynolds number, compared with the smooth helical tube, the average heat transfer augmentation ratio for the two finned tubes is 71% and 103%, but associated with a flow resistance increase of 90% and 140%, respectively. A higher fin height gives a higher heat transfer rate and a larger friction flow resistance. The tests for flow-boiling heat transfer are carried out in 3D internally micro-finned helical tube with a curvature of 0.0605 and a length of 0.668 m. Compared with that in the smooth helical ...

International Nuclear Information System (INIS)

Three dimensional data of brain from the formalin-fixed fetuses were collected without isolation, by the 4.7 tesla super high magnetic field MRI and the developmental process of the cerebral parenchyma was studied by 3D images. Subjects were 13 fetal brain and MRI was performed using 3D-steady-state free precession sequence. The isolated brain is very soft and fragile and is deformed by its weight at the imaging. However 3D-MRI can be obtained without isolation, and the deformation is remarkably small. The subependymal germinal matrix layer did not be observed in 7 weeks-old fetus, appeared at 9 weeks-old and increased gradually. Then it rapidly reduced from 28 weeks-old. The volume calculated, from 3D-MRI, increased rapidly from 9 weeks-old to 23 weeks-old, and reached the maximum (2.346 mm"3) at 23 weeks-old. The ...

International Nuclear Information System (INIS)

The objective was to study the interaction of a side jet with the incoming supersonic flow and hypersonic flow. Qualitatively same Cp trends have been obtained as found experimentally. Also in aerodynamic coefficients side jet interaction results in additional pitching moment which is because of the high pressure region in upstream of the jet and a low pressure region in the downstream of the jet. Also jet interaction results in the rise in the lift coefficient. Whereas in the incidence case, simulation has been performed for the hypersonic flows over a biconic body with supersonic lateral jet at Mach 9.7 and incidence of 0"o to incidence of -12"o and 12"o. The results obtained were compared with the experimental and CFD code CFL3D results. PAK-3D over predicts the surface pressure as compared to the CFL3D and experimental results, whereas the qualitative trends ...

UK PubMed Central (United Kingdom)

A new 3D model is developed to simulate the self-oscillation of the elongated vocal folds. This model allows for large deformation and longitudinal displacement. The displacement boundary condition...Full Text Available

UK PubMed Central (United Kingdom)

Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Twenty-seven patients with symptoms or clinical findings suggesting joint or bone disorders of the anterior chest wall (ACW) were evaluated by spiral CT with 3-dimensional (3-D) and multiplanar reconstructions. Preceding conventional ACW tomography was performed in 10 patients. ACW joint and bone changes were visualized more adequately by coronal 2-D reconstructions based on spiral CT than by conventional tomography. In addition, nonossified costal cartilages and soft tissue lesions were demonstrated. 3-D reconstructions sometimes added information, especially in patients with fracture and dislocation. (orig.).

British Library Electronic Table of Contents (United Kingdom)

The term biological motion is often used by researchers studying the patterns of movement generated by living forms and in sports. We studied a pattern recognition system of motion in sport using biological motion data. Biological motion data are acquired using a 3D motion capture system. However, 3D motion capture systems are very expensive. In this article, a biological motion capture system was built using acceleration sensors. Our proposed system uses the technique of Gaussian fitting and regression analysis. We tested our proposed system in pattern recognition of outdoor tennis and its evaluations.

Science.gov (United States)

A series of pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates was tested for anticonvulsant activity in mice. Eleven of the 15 compounds possessed anticonvulsant activity against pentylenetetrazol-induced convulsions. One compound afforded more anticonvulsant protection against pentylenetetrazol than did trimethadione (67 and 50%, respectively). A suspension of this compound was found to be as effective as a solution in producing anticonvulsant activity. The results suggest that the nitrile analogs were more potent compared to the carbamyl analog due to higher lipid solubility. PMID:7373552

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Radiotherapy recent development in cancer treatment needs strong procedures and quality assessment to improve safety both for patients and professionals. In Ile de France territory, a coordinated action between ASN inspectors and medical doctors specialized in public health (MISP), working as civil servants in health administration, was initiated at the end of 2007. An inspection guideline was implemented in a workshop between ASN and Regional Hospital Agency (ARH). The MISP as health administrator has to verify if care organisation responds to treatment cancer regulatory framework: as a doctor he is authorized to access to patient records to know which treatment was chosen. He has to assure if the therapeutic guidelines are respected. His comprehensive approach is essentially patient-oriented. The MISP inspection coordinated with ASN inspectors is a very pertinent pluri-disciplinary approach, undeniably necessary in such a medical technic. The effectiveness of the ...

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During their catalytic cycle, proteins involved in biological signal transduction undergo unexpectedly large conformational changes, which are at the core of their biological functioning. Until now it has been extremely difficult to obtain experimental insight into the nature of these conformational changes. Mathematical modeling and time-resolved X-ray crystallography have resulted in probable routes along which these conformational changes may take place, but so far this fundamental biological phenomenon has hardly been tackled experimentally. Here, we report on an attempt to observe structural changes in Photoactive Yellow Protein with time-resolved small-angle neutron scattering using diffractometer D22 at the high-flux reactor of the Institut Laue-Langevin, Grenoble, France.

CERN Document Server

Grating cloaks are a variation of dielectric carpet (or ground- plane) cloaks. The latter were introduced by Li and Pendry. In contrast to the numerical work involved in the quasi-conformal carpet cloak, the refractive-index profile of a conformal grating cloak follows a closed and exact analytical form. We have previously mentioned that finite-size conformal grating cloaks may exhibit better cloaking than usual finite-size carpet cloaks. In this letter, we directly visualize their performance using photorealistic ray-tracing simulations. We employ a Newtonian approach that is advantageous compared to conventional ray tracing based on Snell's law. Furthermore, we quantify the achieved cloaking quality by computing the cross-correlations of rendered images. The cross-correlations for the grating cloak are much closer to 100% (i.e., ideal) than those for the Gaussian carpet cloak.

International Nuclear Information System (INIS)

In two recent papers, we constructed a new N#->##infinity# limit of the W_N algebras, which we denote W_#infinity# having generators of conformal spins 2, 3, ..., with central terms for all spins. In this paper, we construct another new algebra, which we denote W_1_+_#infinity#, with generators of conformal spins, 1, 2, 3, ..., again with central terms for all spins. The requirement that the algebras be closed requires that one include the spin-1 generators in W_1_+_#infinity#, and prohibits their inclusion in W_#infinity#. Paralleling our analogous construction for W_#infinity#, we show that the new algebra can also be realised as the antisymmetric part of an associative 'lone-star' product, which also closes on the set of generators with conformal spins #>=#1. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Wind River Resources Corporation (WRRC) received a DOE grant in support of its proposal to acquire, process and interpret fifteen square miles of high-quality 3-D seismic data on non-allotted trust lands of the Uintah and Ouray (Ute) Indian Reservation, northeastern Utah, in 2000. Subsequent to receiving notice that its proposal would be funded, WRRC was able to add ten square miles of adjacent state and federal mineral acreage underlying tribal surface lands by arrangement with the operator of the Flat Rock Field. The twenty-five square mile 3-D seismic survey was conducted during the fall of 2000. The data were processed through the winter of 2000-2001, and initial interpretation took place during the spring of 2001. The initial interpretation identified multiple attractive drilling prospects, two of which were staked and permitted during the summer of 2001. The two initial wells were drilled in ...

UK PubMed Central (United Kingdom)

Angiosarcoma (AS) is a rare and aggressive vascular neoplasm with very poor prognosis. Patients with extensive cutaneous AS who are not surgical candidates have very limited options since there is no...Full Text Available

UK PubMed Central (United Kingdom)

Calculations of dose per monitor unit (D∕MU) are required in addition to measurements to increase patient safety in the clinical practice of proton radiotherapy. As in conventional photon and...Full Text Available

UK PubMed Central (United Kingdom)

Currently several groups are actively researching the integration of a megavoltage teletherapy unit with magnetic resonance (MR) imaging for real-time image-guided radiotherapy. The use of a...Full Text Available

UK PubMed Central (United Kingdom)

PurposeRadiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of PTX and α-tocopherol on...Full Text Available

UK PubMed Central (United Kingdom)

Background:The non-surgical management of non-melanoma skin cancers is an area requiring clinical investigation. Radiotherapy has a role in treatment for a defined subset...Full Text Available

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Bone metastases at the thoracic and lumbar segment of the spine are usually presented with painful sensation and medullar compression. The treatment is based on the clinical and neurological conditions of the patient and the degree of tumor invasion. In the present study, 32 patients with spinal metastasis of thoracic and lumbar segment were prospectively analyzed. These patients were treated by decompression and internal stabilization followed by radiotherapy or irradiation with external immobilization. The election of the groups was in accordance with the tumor radiotherapy sensitivity, clinical conditions, spinal stability, medullar or nerve compression and patient's decision. The Frankel scale and pain visual test were applied at the moment of diagnosis and after 1 and 6 months. The surgical group had better results with preserving the ambulation longer and significant reduction of pain.(author)

International Nuclear Information System (INIS)

Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true risks by one order of magnitude, yet in ...

UK PubMed Central (United Kingdom)

BackgroundTo compare the differences in dose-volume data among coplanar intensity modulated radiotherapy (IMRT), noncoplanar IMRT, and helical tomotherapy (HT) among patients with...Full Text Available

UK PubMed Central (United Kingdom)

Hepatocellular carcinoma (HCC) is one of the most critical global health issues. With frequent association of viral liver disease, HCC is highly complex, harboring both cancer and chronic liver disease....Full Text Available

International Nuclear Information System (INIS)

Methods: Systemic irradiation of neuroaxis is an essential part in the management of medulloblastoma, stPNET and intracranial germ cell tumors. The introduction of quality assurance programs in radiooncology assures a precise radiotherapy of target volumes and is a prerequisite to improve survival. Results: Hyperfractionated radiotherapy has the potential of increasing dose to tumor more safely without increasing the risk for late adverse effects. Pilot studies revealed excellent tumor control in medulloblastoma with acceptable acute toxicity and a long-term survival of up to 96%. In medulloblastoma stereotactic radiation techniques reveal an acceptable toxicity and promising results in tumor control in recurrent disease or as primary treatment. They are now part of future treatment protocols in case of persisting residual tumor. Radiotherapy alone in pure germinoma is continuously yielding high cure rates. In secreting ...

UK PubMed Central (United Kingdom)

PurposeWe previously reported a randomized phase II clinical trial combining a poxvirus-based vaccine encoding PSA with radiotherapy in patients with localized prostate...Full Text Available

International Nuclear Information System (INIS)

The commutators of standard Virasoro generators and fields generate various representations of the centreless Virasoro algebra depending on a conformal dimension J of the field in question (J is related to the Bargmann index of SU(1,1) generated by L_m, m=0,#+-#1). We introduce the notion of q-conformal dimension for various oscillator realizations of q-deformed Virasoro (super)algebras proposed earlier. We use the field theoretical approach introduced recently in which the q-Virasoro currents L"#alpha# (z) are expressed as Schwinger-like point-split normally ordered quadratic expressions in elementary fields. We extend this approach and probe the elementary fields A(z) (the q-superstring coordinate, momentum and fermionic field) and their powers by the q-Virasoro generators L"#alpha#_m (i.e. we calculate the commutators [L"#alpha#_m,A(z)]) and show that to all of them can be assigned just the standard non-deformed ...

UK PubMed Central (United Kingdom)

SummaryIt has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states. The extent to which amyloid structures...Full Text Available

UK PubMed Central (United Kingdom)

A combined approach based on the use of ATR-FT/IR and steady-state fluorescence spectroscopy allowed to shed light on the effects of the additive methoxypolyethylene glycol (MePEG) on the hydration,...Full Text Available

International Nuclear Information System (INIS)

We obtain a symmetry algebra for any unitary minimal model by using the representation of conformal field theories. This symmetry algebra can be interpreted as a quantum group. The generalization to non-unitary minimal models is direct. (orig.).

UK PubMed Central (United Kingdom)

We demonstrate by using low-temperature high-resolution spectroscopy that red-shifted mutants of green fluorescent protein are photo-interconverted among three conformations and are, therefore, not...Full Text Available

UK PubMed Central (United Kingdom)

The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available

UK PubMed Central (United Kingdom)

To assemble into functional structures, biopolymers search for global minima through their folding potential energy surfaces to find the native conformation. However, this process can be hindered by...Full Text Available

UK PubMed Central (United Kingdom)

FXYD1 (phospholemman) is a member of an evolutionarily conserved family of membrane proteins that regulate the function of the Na,K-ATPase enzyme complex in specific tissues and specific physiological...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

International Nuclear Information System (INIS)

Electronic circular dichroism (ECD) of the n-#pi# and #pi# -#pi# transitions of the amide groups in the ultraviolet has become an indispensable tool for qualitative characterization of proteins in solution. Since the existence of such a spectrum (that is, of natural optical activity) comes from the three dimensional interaction of the chromophores in the molecule, CD is exquisitely sensitive to molecular conformation. However, in proteins, the amide transitions available in the near UV are limited in number and are broads and overlapping. Interactions among them yield information about the polymeric backbone, but since such amide electronic excitation are relatively delocalized, the resulting

International Nuclear Information System (INIS)

Open descendants extend conformal field theory to unoriented surfaces with boundaries. The construction rests on two types of generalizations of the fusion algebra. The first is needed even in the relatively simple case of diagonal models. It leads to a new tensor that satisfies the fusion algebra, but whose entries are signed integers. The second is needed when dealing with non-diagonal models, where Cardy's ansatz does not apply. It leads to a new tensor with positive integer entries, that satisfies a set of polynomial equations and encodes the classification of the allowed boundary operators. (orig.).

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Extended conformal algebras with supersymmetry (super-W/sub n/ algebra) is constructed and the algebras are shown to exist for special values of the central charge c. The super-W/sub n/ algebra containing currents of spin (5/2, 3) has a unitary representation (c=10/7) and a non-unitary one (c=-5/2), and the super-W/sub n/ algebra containing currents of spins (2, 5/2) has a non-unitary representation (c=-6/5).

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The crystal and molecular structures of the anti-acquired immunodeficiency syndrome agent 3'-azido-3'-deoxythymidine (AZT) have been determined by x-ray diffraction. There are two crystallographically independent AZT molecules in the crystal asymmetric unit; they have similar conformation and differ primarily in the glycosyl torsion angle. Comparisons with a hydrated thymidylate structure indicate that the azido group does not significantly affect the gross conformational preference of the molecule. The comparisons also suggest possible functional roles for the azido group in enzyme binding.

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K{beta}-to-K{alpha} X-ray intensity ratios of Ti, Cr, Fe and Co in pure metals and in Cr{sub 0.26}Fe{sub 0.74}, Cr{sub 0.80}Co{sub 0.20} and Ti{sub 0.80}Cr{sub 0.20} alloys have been measured following excitation by 59.54 keV {gamma}-rays from a 7400 MBq (200 mCi) {sup 241}Am point-source. The valence electronic structure of Ti, Cr, Fe and Co in the samples have been evaluated by the comparison of the measured K{beta}-to-K{alpha} intensity ratios with the results of multiconfiguration Dirac-Fock calculations performed for various electronic configurations of these metals. The 3d-electron populations obtained for pure metallic Ti, Cr, Fe and Co agree well with the results of band structure calculations of Papaconstantopoulos (Handbook of band structure of elemental solids, Plenum Press, New York, 1986). Our analysis indicates significant increase of 3d-electron population of Ti, Cr and Fe in the alloys ...

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Computation of effective flow properties of fluids in porous media based on three dimensional (3D) pore structure information has become more successful in the last few years, due to both improvements in the input data and the network models. Computed X-ray microtomography has been successful in 3D pore imaging at micron scale, which is adequate for many sandstones. For other rocks of economic interest, such as chalk and diatomite, submicron resolution is needed in order to resolve the 3D-pore structure. To achieve submicron resolution, a new method of sample serial sectioning and imaging using Focused Ion Beam (FIB) technology has been developed and 3D pore images of the pore system for diatomite and chalk have been obtained. FIB was used in the milling of layers as wide as 50 micrometers and as thin as 100 nanometers ...

International Nuclear Information System (INIS)

The experimental has been performed with a view to studying complete and incomplete fusion in "1"4N + "1"6"3D_y system below 7 MeV/nucleon. The excitation functions for several reactions have been measured using the activation technique and compared with the theoretical predictions based on statistical models. The codes ALICE-91 and CASCADE used earlier for the analysis of excitation functions in case of "1"2C + "1"6"5H_0 system have been used here also with the same set of input parameters. It has been observed that the theoretical calculations do not match with the experimental excitation functions well but the overall shape of the excitation function is reproduced satisfactorily. The composite nucleus ("1"7"7T_a) formed in this ("1"4N + "1"6"3D_y) case is the same as the one formed in "1"2C + "1"6"5H_0 system studied earlier. Measured excitation functions for the same decay channels in the two cases ...

Energy Technology Data Exchange (ETDEWEB)

3-D depth migration is one of the most active areas of research and development and it has been approached from different angles. An accurate algorithm which works in the space-frequency domain was introduced by Blacquiere et al. (1989). Unfortunately, it is computationally very expensive and not suitable for solving real-life 3-D migration problems. This led to the development of an alternative scheme (hale, 1990) which sacrifices some accuracy but is much more efficient. It is commonly referred to as the Hale-McClellan method. An alternative procedure known as reverse-time migration works in the space-time domain. It is based on the full wave equation and yields by far the most accurate results, but it requires extremely large computer resources. However, a series of new developments (Mufti et al, 1996) have made this algorithm a very practical tool even for migrating large exploration-scale ...

International Nuclear Information System (INIS)

K?-to-K? X-ray intensity ratios of Ti and Ni have been measured in pure metals and in alloys of TixNi1-x (x=0.7, 0.6, 0.5, 0.4 and 0.3) following excitation by 22.69 keV X-rays from a 10 mCi 109Cd radioactive point source. The valence-electron configurations of these metals were determined by corporation of measured K?-to-K? X-ray intensity ratios with the results of multiconfiguration Dirac-Fock calculation for various valence-electron configurations. Valence-electron configurations of 3d-transition metals in alloys indicate significant differences with respect to the pure metals. Our analysis indicates that these differences arise from delocalization and/or charge transfer phenomena in alloys. Namely, the observed change of the valence-electron configurations of metals in alloys can be explained with the transfer of 3d electrons from one element to the other element and/or the rearrangement of ...

Energy Technology Data Exchange (ETDEWEB)

The 3-D model program was developed to apply a mise-a-la-masse method to linear current sources with optional shapes. Mise-a-la-masse method is a bipolar mapping survey method using current sources installed in wells, and recently has been widely used for direct exploration of geothermal reservoirs. This method is also used for monitoring underground fluid as electrode arrangement of fluid flow tomography for surveying underground fluid (geothermal fluid, underground water, petroleum). In the geothermal reservoir exploration, the casing pipes of wells are used as linear current sources, and measured data are processed as those based on vertical current source. In the largely inclined well, the inclination of current sources should be considered. The 3-D modeling program was developed by difference calculus using the theoretical potential equation and apparent resistivity based on linear current sources ...

Energy Technology Data Exchange (ETDEWEB)

Finite element method is one of the bases for numerical solutions to engineering problems. Complex engineering problems using finite element analysis typically imply excessively large computational time. Parallel supercomputers have the potential for significantly increasing calculation speeds in order to meet these computational requirements. This paper predicts parallel NIKE3D performance on the Kendall Square Research (KSR1) system. The first part of the prediction is based on the implementation of parallel Cholesky (U{sup T}DU) matrix decomposition algorithm through actual computations on the KSRI multiprocessor system, with 64 processors, at Oak Ridge National Laboratory. The other predictions are based on actual computations for parallel element matrix generation, parallel global stiffness matrix assembly, and parallel forward/backward substitution on the BBN TC2000 multiprocessor system at Lawrence Livermore National Laboratory. The ...

International Nuclear Information System (INIS)

With the objective to improve the reactor physics calculation on a 2D and 3D nuclear reactor via the Diffusion Equation, an adaptive automatic finite element remeshing method, based on the elementary area (2D) or volume (3D) constraints, has been developed. The adaptive remeshing technique, guided by a posteriori error estimator, makes use of two external mesh generator programs: Triangle and TetGen. The use of these free external finite element mesh generators and an adaptive remeshing technique based on the current field continuity show that they are powerful tools to improve the neutron flux distribution calculation and by consequence the power solution of the reactor core even though they have a minor influence on the critical coefficient of the calculated reactor core examples. Two numerical examples are presented: the 2D IAEA reactor core numerical benchmark and the ...

Energy Technology Data Exchange (ETDEWEB)

The Computational Fluid Dynamics(CFD) study was conducted to assess the new design concept introduced to solve the issues on the flow deviation between SG cassettes and the supporting structure design of the flow distributing plate subjected to the flow induced vibration. Flow field from MCP to the bottom of SG was modeled for 2-dimensional(2D) CFD analysis and then sensitivity analysis on major design parameters was conducted using commercial CFD code, Fluent. The cases for detailed 3D analysis were selected based on the result of 2D analysis and the detailed 3-dimensional(3D) analysis was conducted for these selected cases using Fluent code. Flow field was modeled by RNG model and wall function, 2nd upwind scheme, porous model, structured or hybrid grid. The analysis result shows that the maximum deviation of flow distribution between SG cassettes was reduced upto about 0.1% and the pressure loss from ...

International Nuclear Information System (INIS)

Techniques for reducing computation time in 3D photon dose calculations are addressed with specific emphasis given to the convolution/superposition approach. A single polyenergetic superposition model calculating absorbed dose per incident photon fluence (Gy cm"2) was developed in terms of TERMA and a total energy deposition kernel (a total point spread function). A novel approach was devised for reducing calculation time. The method, named the CF method, was based on the use of a conventional, fast model (here a modified power-law method was used) for the generation of 3D dose distributions on a fine dose matrix. Superposition calculations were carried out on a coarse matrix and calculation speed was increased simply by reducing the number of calculations. A set of correction factors was derived on the coarse grid from the ratio of the dose values from superposition to those from the conventional ...

Energy Technology Data Exchange (ETDEWEB)

In addition to the ability to solve the static transport equation, we have also incorporated time dependence into our parallel 3-D S{sub {ital N}} code DANTSYS/MPI. Using a semi-implicit scheme, DANTSYS/MPI is capable of performing time-dependent calculations for both fissioning and pure source driven problems. We have applied this to various types of problems such as nuclear well logging and prompt fission experiments. This paper describes the form of the time- dependent equations implemented, their solution strategies in DANTSYS/MPI including iteration acceleration, and the strategies used for time-step control. Results are presented for a model nuclear well logging calculation.

Energy Technology Data Exchange (ETDEWEB)

The intermediate silicon layers detector (ISL) was proposed as a part of the upgraded CDF detector at the RUN-II of the Tevatron mean value of pp collider at Fermilab, scheduled to start in year 2000. The ISL is a large-radius (20-30 cm) silicon tracker with a total active area of about 3.5 m. Located in the region between the silicon vertex detector and the central outer tracker, the ISL will allow tracking in the forward region and significantly improve it in the central area. Together with the SVX II the ISL forms a standalone, 3D silicon tracker. The challenge is to build a low-cost device which provides precise 3 D tracking in a approximately equal to 2 m long area with a minimal amount of material for the supporting structure. The conceptual design and the status of the project are reviewed.

International Nuclear Information System (INIS)

He ions incident at grazing angles on Cu(110) and Ni(110) surfaces are neutralised into triplet and singlet states, of which the 3p, 3d and 4d upper states are accessible to optical spectroscopy. In the energy range from 500 eV to 15 keV no significant energy dependence of the relative intensities of singlet and triplet lines was observed for scattering on Cu(110). The intensities from Ni(110) are higher and the singlet to triplet intensity ratio of the 3d to 2p transition is about 6% smaller than that from Cu(110). The results can be explained well by assuming resonant charge capture into excited He and intermediate formation of negative He"- states. (orig.).

International Nuclear Information System (INIS)

Energy-filtered X-ray photoemission electron microscopy (EXPEEM) is a microscopy technique which has the potential to provide surface chemical mapping during surface chemical processes on the nanometer scale. We studied the possibilities of EXPEEM using a Wien filter type energy analyzer in the high energy X-ray region above 1000 eV. We have successfully observed the EXPEEM images of Au islands on a Ta sheet using Au 3d_5_/_2 and Ta 3d_5_/_2 photoelectron peaks which were excited by 2380 eV X-rays emitted from an undulator (BL2A) at Photon Factory. Our recent efforts to improve the sensitivity of the Wien filter energy analyzer will also be discussed.

British Library Electronic Table of Contents (United Kingdom)

In this paper we review and classify the various patterns of isosteric heat versus loading for adsorption of gases on graphitised thermal carbon black at temperatures ranging from below the 3D triple point to temperatures above it, but less than the 3D critical point. We have identified the features of heat curve and highlighted the microscopic origin of these features. The patterns vary with temperature and with the relative strength of the fluid-fluid interaction and solid-fluid interaction. For simple adsorptives (by simple we meant there is no strong association between fluid particles), the heat curve is typified by fluid-fluid attraction and layering phenomena. For adsorptives showing strong association such as water, ammonia and methanol, the heat curve essentially begins below the ...

British Library Electronic Table of Contents (United Kingdom)

Statement of problem Inadequate dimensioning of the connectors in a cantilever cross-arch fixed dental prosthesis (FDP) in perioprosthetic patients jeopardizes the prognosis of the restoration. Purpose The purpose of this study was to investigate the effect of increasing the vertical dimension (VD) on the maximum stress developed within the connectors during the static loading of a cross-arch FDP extended as a 1- and 2-unit cantilever. Material and methods Six digital models were developed, derived from a 3-dimensional (3-D) initial model. In the initial model, the teeth were prepared for metal ceramic restorations and splinted with a cross-arch FDP, extended as a 1- or 2-unit cantilever. The VDs of the connectors proximal to the retaining abutment were 3, 4, or 5 mm. A 3-D finite element ...

International Nuclear Information System (INIS)

The objective of this project is to develop multi-dimensional computational models in order to improve the operation of uranium electrorefiners currently used in pyroprocessing technology. These 2-D (US) and 3-D (ROK) mathematical models are based on the fundamental physical and chemical properties of the electrorefiner processes. The validated models by compiled and evaluated experimental data could provide better information for developing advanced electrorefiners for uranium recovery. The research results in this period are as follows: - Successfully assessed a common computational platform for the modeling work and identify spatial characterization requirements. - Successfully developed a 3-D electro-fluid dynamic electrorefiner model. - Successfully validated and benchmarked the two multi-dimensional models with compiled experimental data sets

International Nuclear Information System (INIS)

We present a fully automated method for three-dimensional (3D) elemental analysis demonstrated using a ceramic sample of chemistry (Ca)MgTiO_x. The specimen is serially sectioned by a focused ion beam (FIB) microscope, and energy-dispersive X-ray spectrometry (EDXS) is used for elemental analysis of each cross-section created. A 3D elemental model is reconstructed from the stack of two-dimensional (2D) data. This work concentrates on issues arising from process automation, the large sample volume of approximately 17x17x10 #mu#m"3, and the insulating nature of the specimen. A new routine for post-acquisition data correction of different drift effects is demonstrated. Furthermore, it is shown that EDXS data may be erroneous for specimens containing voids, and that back-scattered electron images have to be used to correct for these errors.

CERN Document Server

At Super-LHC luminosity it is expected that the standard suite of L1 triggers for CMS will saturate. Information from the tracker will be needed to reduce trigger rates to satisfy the L1 bandwidth. Tracking trigger modules which correlate information from closely-spaced sensor layers to form an on-detector momentum filter are being developed by several groups. We report on a trigger module design which utilizes three dimensional IC technology to incorporate chips which are connected both to the top and bottom sensor, providing the ability to filter information locally. A demonstration chip, the VICTR, has been submitted to the Chartered/Tezzaron two-tier 3D run coordinated by Fermilab. We report on the 3D design concept, the status of the VICTR chip and associated sensor integration utilizing oxide bonding.

Energy Technology Data Exchange (ETDEWEB)

Radio-biologists have pointed out a novel radiobiological phenomenon observed in many tumor and normal cell lines: hyper-radiosensitivity to very low-dose (H.R.S.) followed by induced radioresistance (I.R.R.) after a threshold dose of 0.1-0.3 Gy that depends on the cell line. Radioresistance at high dose (i.e. higher than 0.5 Gy) and metastatic potential of tumor cells are likely major factors of failure in radiotherapy. A careful review of literature suggests that: 1) radiotherapy does not increase the metastatic potential of tumor cells; 2) radioresistance at high dose and metastatic potential are not related. However, inside a given tumor cell line, highly metastatic clones may elicit more cells showing H.R.S; or are more radiosensitive at high dose than poorly metastatic ones. Recent data obtained from molecular techniques (comet and immunofluorescence assays) applied to single cells irradiated at very low radiation doses (1-100 mGy) ...

International Nuclear Information System (INIS)

The aim of this study was to evaluate the results of postoperative radiotherapy in a case of perihilar cholagiocarcinoma by analyzing overall survival rate, patterns of failure, prognostic factors for overall survival, and toxicity. Between January 1998 and March 2008, 38 patients with perihilar cholangiocarcinoma underwent a surgical resection and adjuvant radiotherapy. The median patient age was 59 years (range, 28 to 72 years), which included 23 men and 15 women. The extent of surgery was complete resection in 9 patients, microscopically positive margins in 25 patients, and a subtotal resection in 4 patients. The tumor bed and regional lymphatics initially received 45 Gy or 50 Gy, but was subsequently boosted to a total dose of 59.4 Gy or 60 Gy in incompletely resected patients. The median radiotherapy dose was 59.4 Gy. Concurrent chemotherapy was administered in 30 patients. The median follow-up period was 14 months ...

International Nuclear Information System (INIS)

Purpose: Treatment results and the pattern of relapse were evaluated in the multimodal treatment of Ewing's sarcomas of the chest wall. Methods and Materials: In a retrospective analysis, 114 patients with non-metastatic Ewing's sarcoma of the chest wall were evaluated. They were treated in the CESS 81, CESS 86, or EICESS 92 studies between January 1981 and December 1993. The treatment consisted of polychemotherapy (VACA, VAIA, or EVAIA) and local therapy, either surgery alone (14 patients), radiotherapy alone (28 patients) or a combination of both (71 patients). The median follow-up was 46.6 months (range 5-170). A relapse analysis for all patients with local or combined relapses was performed. Results: Overall survival was 60% after 5 years, event-free survival was 50%. Thirty-seven patients had a systemic relapse (32.4%), 11 patients had a local relapse alone (9.6%), and 3 patients had a combined local and systemic relapse (2.6%). The risk to relapse locally ...

Science.gov (United States)

zb l:7R cq~` ;qqw scq- !;m#] QLBr90 NJThh 4vwCb :o5!3: $|1y .8Bj -A}8 -^uY .,4G WDl7 72qBD ;tDGCq MXgF 9[1"r3 :D)nJ+ &&orq l'j"c/ Lk^q 't|#b c3~5 :&c|$ ...

International Nuclear Information System (INIS)

The main features are presented of a computer programme for 3-D thermohydraulic and thermodynamic analysis of the PGV-1000 horizontal steam generator used at the Temelin NPP. The programme provides analyses of primary side hydraulics, heat exchange behavior and the steam generator secondary side thermohydraulics and thermodynamics. Given are calculated data on the circulation flow rate, void fraction, heat transfer dynamics and the swelled level. (Z.S.) 9 figs.

Energy Technology Data Exchange (ETDEWEB)

Already, MR Imaging is superior in diagnostic imaging of joints in many cases; however, there have been recent developments, which are the subjects of this paper. With gradient-echo sequences acquired in 3D technique, it is possible to produce high-resolution images of joints in acceptable scantime, because gradient-echo sequences are less time-consuming than convential SE sequences. With the acquisition of two echoes, phase difference between water and fat protons have to be considered. 3D Imaging is capable of displaying complex pathology in a superior way, which should be useful in preoperative planning. Tissue contrast is altered by fat saturation or magnetization transfer in order to achieve better conspicuity of lesions. Although diagnostic value of some of these options is not yet clear and further clinical studies are needed, they are a promising possibility for improving MR Imaging of the ...

Energy Technology Data Exchange (ETDEWEB)

We report on solid solution CePd[sub 2-x]Mn[sub x]Si[sub 2] which shows an interesting transition of the Ce-ion from magnetism in a Kondo regime to an intermediate valence state coupled with a strongly magnetic 3d sublattice. ((orig.))

Science.gov (United States)

Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with {sup c}losure laws{sup .} Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account ...

International Nuclear Information System (INIS)

The electronic structure of octahedral metal atom clusters Me_6 of 3d, 4d, and 5d transition metal atoms (V, Cr; Nb, Mo; Ta, W) has been calculated applying two different quantum-chemical approximation methods (Extended Hueckel (EH) method; SW-Xsub(alpha) method). Equilibrium structures, energy level schemes, Fermi energies and band widths as well as densities of states of clusters are discussed in detail.

International Nuclear Information System (INIS)

The influence that electromagnetic fields have on mechanical and electronic equipment was discussed. A three dimensional numerical simulation model of electric fields around high voltage power transmission lines was described. 4 refs., 1 tab., 5 figs.

Science.gov (United States)

Under support from the French Space Agency (CNES), a 3D+t dusty-gas model of Comet 67P/Churyumov-Gerasimenko is being developed, to compute, from the first 2014 Rosetta orbital data, the aerodynamic forces exerted on the Rosetta orbiter and on the descent lander. We report the recently developed dust dynamics part of the code. The multi-species (presently H2O and CO) gas code is optimized in terms of computational speed owing to the use of two complementary methods: (a) 3D+t Direct Simulation Monte Carlo (DSMC) runs in the non-equilibrium regions adjacent to the surface and very distant from it, and (b) solutions of the Navier-Stokes equations in-between. The model is used presently using Lamy et al. (Space Sci. Rev., 2007, 128, 23) coarse information on 67P nucleus shape and rotation, and a range of possible gas production rates Q for the early Rosetta observations at rh 3 AU (Q 1026 - 1027 s-1). In ...

International Nuclear Information System (INIS)

A method for calculation of absorbed dose distributions in three dimensions for 1-20 MeV photons is presented. The method uses convolution/superposition of photon fluence distributions with energy scattering kernels. Results for Co-60 and X-ray beams in homogeneous and inhomogeneous media are compared with measurements. Good agreement is found between calculations and measurements. 8 refs.; 3 figs.

International Nuclear Information System (INIS)

A book has been written to introduce the physical aspects of the radiotherapy electron beam by presenting a summary of the developments in this field. The first chapter is a brief introduction to the technology of medical accelerators with emphasis on the electron beam production facilities. Chapter 2 describes the interaction processes at the atomic level once the electron beam enters the medium. Chapter 3 is concerned with the various properties of the electron beam purely from the clinical point of view. The electron beam algorithms and models for distribution calculations are covered in Chapter 4 with inclusion of age diffusion and multiple scattering approaches. The factors affecting the beam distribution in a patient, with inhomogeneities, surface irregularities, backscattering etc. are discussed in Chapter 5. The last two chapters are devoted to electron beam dosimetry including various dosimetric methods, specification and measurement of beam energy, ...

Energy Technology Data Exchange (ETDEWEB)

Purpose: The aim of this study was to evaluate the accuracy of MRI in the measurement of cartilage thickness of the ankle joint in comparison to pathologic and histologic specimens. Patients and methods: The ankle joints of four fresh cadaver feet were imaged on a 1.5 T MR-unit in the coronal plane. Standard T{sub 1}-weighted spin echo (SE) and a T{sub 1}-weighted 3D-GE (FLASH-3D) sequence with fat saturation were applied. Following MR imaging, the talus was explanted and cut parallel to the MR images for macroscopic evaluation and histologic specimens were prepared. MRI measurements of the cartilage thickness of the talus were carried out in two ways: Without and with consideration of a transition zone of intermediate signal intensity between hyperintense cartilage and hypointense cortical bone. The data were compared with the anatomic specimens as the gold standard expressing the difference as a ...

Energy Technology Data Exchange (ETDEWEB)

NMR and CD studies indicate that Mg/sup 2 +/ and Ca/sup 2 +/ are able to change the conformation of tetracycline in DMSO solution. This may affect the in vivo effect of tetracycline. Using /sup 23/Na NMR, the formation constant of NaLAS (LAS represents the anion of lasalocid A) was found to be 80 M/sup -1/ which is much smaller than that in less polar solvents. Spin-lattice relaxation measurements were made to study the binding sites of Gd/sup 3 +/ on Las in ChCl/sub 3/-DMF mixed solvent system. No intermediate conformation (between cyclic and open-chain) was found. LAS was found to be a good second-sphere ligand to inert transition-metal amines. NMR studies suggest that LAS is in cyclic conformation when bound to these metal amines. A new method for the synthesis of spin-labeled anticancer Pt(II) complexes was developed. It is very simple and gives high yield of pure spin-labeled Pt(II) complexes.

Energy Technology Data Exchange (ETDEWEB)

The dosimetry for radiotherapy involving neutrons is very complicated, owing to the complexity of secondary radiation components, whose contributions to the total absorbed dose have to be discriminated, owing to the different radiobiological effects. In order to separate thermal neutrons and photons, LiF dosimeters are mostly utilized. containing different percentage of Li, like as TLD-700, TLD-100 and TLD-600, but many problems arise. In the response of TLD-700 exposed to neutron-gamma mixed fields with high neutron flux, the contribution of thermal neutrons to the Tl emission is high. Moreover. TLD-100 and TLD-600 may undergo radiation damage, and great care has to be taken in order to obtain reliable results. Other TLDs showing lower sensitivity to neutrons are proposed and experimented for such high-flux neutron fields. The faced problems and various proposed solutions are here described. (Author)

International Nuclear Information System (INIS)

Local control of Ewing's sarcoma was analysed in a series of 67 patients treated by surgery and/or radiotherapy as well as combination chemotherapy. Radiotherapy was employed with or without surgery in 60 patients and produced an overall local control rate of 55%; complete excision of the primary lesion seemed to be beneficial. There was a marked variation in control rates depending on the site of the primary lesion: limb 85%, rib 53%, pelvis 31% and other sites 33%.Primary tumours greater than 10 cm in diameter were significantly less likely to be controlled. Using daily fractions of approximately 180 cGy, total doses in excess of 6000 cGy seem more likely to produce serious late morbidity amd may not increase the local control rate. No cases of second malignancy arising in irradiated tissue have been observed to date, but one patient developed acute lymphoblastic leukaemia. (author).

International Nuclear Information System (INIS)

The behaviors of peripheral eosinophils during radiotherapy were examined in 200 cases of non-resected cervical cancer. Before irradiation, the mean absolute eosinophil count had been 170 +- 168/mm_3, and eosinophilia (more than 500/mm_3) had been observed in 11 cases (5.5%). Postirradiation eosinophilia occurred in 126 cases (63%). The mean period between institution of irradiation and the peak of the eosinophil count was 27.8 days. The mean highest eosinophil count was 691 +- 437/mm_3, and the mean bone marrow dose in this period was 906 rad. Comparisons of the eosinophil count according to the stage showed no significant differences. (Chiba, N.).

CERN Document Server

Over the last few years, string theory has changed profoundly. Most importantly, novel duality relations have emerged which involve gauge theories of brane excitations on one side and various closed string backgrounds on the other. In this lecture, we introduce the fundamental ingredients of modern string theory and explain how they are modeled through 2D (boundary) conformal field theory. This so-called `microscopic description' of strings and branes is an active research area with new results ranging from the classification and construction of boundary conditions to studies of 2D renormalization group flows. We shall provide an overview of such developments before concluding the lecture with an extensive outlook on some research that is motivated by current problems in string theory. This includes investigations of non-rational and non-unitary conformal field theories.

CERN Document Server

One of the salient features of human perception is its invariance under dilatation in addition to the Euclidean group, but its non-invariance under special conformal transformation. We investigate a holographic approach to the information processing in image discrimination with this feature. We claim that a strongly coupled analogue of the statistical model proposed by Bialek and Zee can be holographically realized in scale invariant but non-conformal Euclidean geometries. We identify the Bayesian probability distribution of our generalized Bialek-Zee model with the GKPW partition function of the dual gravitational system. We provide a concrete example of the geometric configuration based on a vector condensation model coupled with the Euclidean Einstein-Hilbert action. From the proposed geometry, we study sample correlation functions to compute the Bayesian probability distribution.

International Nuclear Information System (INIS)

Most surface-acoustic-wave and thin-film optical devices are made by the planar fabrication process. The exposure of the pattern in the polymer film is the first and most crucial step in ensuring desired device geometry, dimensional control, and freedom from pattern distortion. The methods of exposing the polymer film include: optical projection, conventional contact printing, conformable photomask contact printing, holographic recording, scanning electron beam lithography, projection electron lithography, and x-ray lithography. In this paper scanning electron beam lithography, conformable photomask contact printing, holographic recording, and x-ray lithography are discussed. In the last section, ion beam etching of relief structures is discussed.

Energy Technology Data Exchange (ETDEWEB)

New technologies are needed to reduce the current high rate of well abandonment. Improved sweep efficiency, reservoir conformance, and permeability modification can have a significant impact on oil recovery processes. Microorganisms can be used to selectively plug high-permeability zones to improve sweep efficiency and impart conformance control. Studies of a promising microbial system for polymer production were conducted to evaluate reservoir conditions in which this system would be effective. Factors which can affect microbial growth and polymer production include salinity, pH, temperature, divalent ions, presence of residual oil, and rock matrix. Flask tests and coreflooding experiments were conducted to optimize and evaluate the effectiveness of this system. Nuclear magnetic resonance imaging (NMRI) was used to visualize microbial polymer production in porous media. Changes in fluid distribution within the pore system of the core were ...

UK PubMed Central (United Kingdom)

Multiple myeloma is a highly radiosensitive skeletal malignancy, but bone-seeking radionuclides have not yet found their place in disease management. We previously reported that the proteasome inhibitor...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The document, based on European guidelines, was jointly developed by radiation oncologists, radiation physicists and radiation technologists. It contains the aims of the guidelines, professional profiles, roles and responsibilities, personnel and equipment requirements, procedures.

UK PubMed Central (United Kingdom)

33 patients with advanced malignant melanoma were studied after intravenous administration of 131I-labeled Fab fragments specific for p97, an oncofetal glycoprotein of human melanoma. In all, 47 gamma...Full Text Available

International Nuclear Information System (INIS)

A review of main issues in diagnosing, complex treatment and prognosis of Ewing's sarcoma is presented. Current trend in chemotherapy, radiotherapy and surgery of the disease is discussed. Unfavourable prognosis is attributed to the systematic character of the disease, necessitating a complex therapeutic approach. Attempts to make an optimal combination of the three therapeutic methods in order to improve survival and reduce the rate of post-treatment complications are analyzed. 37 refs., 4 tabs. (author).

UK PubMed Central (United Kingdom)

PurposeRTOG protocol 95-17 was a phase I/II trial to evaluate multi-catheter brachytherapy as the sole method of adjuvant breast radiotherapy for stage I/II breast...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

An imaging detector for {gamma}-rays ({approx equal}1 MeV) based on minicell MWPCs with converters and a position resolution of {Delta}x=0.5 mm has been developed and tested. Very high rate capability (>10{sup 8}/cm{sup 2} s) and a special readout for suppression of scattered radiation are implemented allowing to enhance the measured contrast. The relevant physical processes are discussed and first pictures are presented. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Using the boson-fermion equivalence in 2-d conformal field theory and the boson-boson equivalence of the superconformal bosonic ghost fields of the string theory, the authors construct a level {Kappa} = +1 representation of the affine superalgebra OSp(M*N)/sup 1/ in terms of vertex operators.