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Sample records for 2p 3p 5q

  1. Doubly excited 2s2p 1,3p1 resonances in photoionization of helium

    Wan Jian-Jie; Dong Chen-Zhong

    2009-01-01

    The multi-configuration Dirac-Fock (MCDF) method is implemented to study doubly excited 2s2p 1,3P1 resonances of the helium atom and the interference between photoionization and photoexcitation autoionization processes.In order to reproduce the total photoionization sprectra,the excited energies from the ground ls2 1 S0 state to the doubly excited 2s2p 1'3P1 states and the relevant Auger decay rates and widths are calculated in detail. Furthermore,the interference profile determined by the so-called Fano parameters q and p2 is also reproduced. Good agreement is found between the present results and other available theoretical and experimental results. This indeed shows a promising way to investigate the Fano resonances in photoionization of atoms within the MCDF scheme,although there are some discrepancies in the present calculations of the 2s2p 3P1 state.

  2. Controlling the $2p$ Hole Alignment in Neon via the $2s$-$3p$ Fano Resonance

    Heinrich-Josties, Elisabeth; Santra, Robin

    2014-01-01

    We study the state-resolved production of neon ion after resonant photoionization of Ne via the $2s$-$3p$ Fano resonance. We find that by tuning the photon energy across the Fano resonance a surprisingly high control over the alignment of the final $2p$ hole along the polarization direction can be achieved. In this way hole alignments can be created that are otherwise very hard to achieve. The mechanism responsible for this hole alignment is the destructive interference of the direct and indirect (via the autoionizing $2s^{-1}3p$ state) ionization pathways of $2p$. By changing the photon energy the strength of the interference varies and $2p$-hole alignments with ratios up to 19:1 between $2p_0$ and $2p_{\\pm 1}$ holes can be created: an effect normally only encountered in tunnel ionization using strong-field IR pulses. Including spin-orbit interaction does not change the qualitative feature and leads only to a reduction in the alignment by $2/3$. Our study is based on a time-dependent configuration-interactio...

  3. (2p2)3P state of H- and the convergence of the CI series

    A sequence of increasingly accurate configuration interaction (CI) wave functions is used to discuss binding and the convergence of the CI series for the (2p2)3P state of H-. We get an upper bound energy E/sub u/=-0.1 253 547 166 a.u.(H), the lowest yet obtained, lying within an estimated 0.4 μhartree from the exact eigenvalue of Schroedinger's nonrelativistic equation. The angular energy limits define angular energy increments ΔE/sub l/ which follows the formula ΔE/sub l/approx. =0.18 (l+1/2)-7a.u. for l> or =4. Five or eighty per cent of binding is obtained with a three-term Psi=c1(2p)2+c2(2p')2+c3 (3d)2 depending on whether the 2p,2p', and 3d orbitals are energy optimized STO's or accurate natural orbitals, respectively

  4. Hyperfine Quenching of the 2s2p 3P0 State of Berylliumlike Ions

    Cheng, K T; Chen, M H; Johnson, W R

    2008-03-13

    The hyperfine-induced 2s2p {sup 3}P{sub 0}-2s{sup 2} {sup 1}S{sub 0} transition rate for Be-like {sup 47}Ti{sup 18+} was recently measured in a storage-ring experiment by Schippers et al. [Phys. Rev. Lett. 98, 033001 (2007)]. The measured value of 0.56(3) s{sup -1} is almost 60% larger than the theoretical value of 0.356 s{sup -1} from a multiconfiguration Dirac-Fock calculation by Marques et al. [Phys. Rev. A 47, 929 (1993)]. In this work, we use a large-scale relativistic configuration-interaction method to calculate these hyperfine-induced rates for ions with Z = 6-92. Coherent hyperfine-quenching effects between the 2s2p {sup 1,3}P{sub 1} states are included in a perturbative as well as a radiation damping approach. Contrary to the claims of Marques et al., contributions from the {sup 1}P{sub 1} state are substantial and lead to a hyperfine-induced rate of 0.67 s{sup -1}, in better agreement with, though larger than, the measured value.

  5. Unified interpretation of Hund's first and second rules for 2p and 3p atoms.

    Oyamada, Takayuki; Hongo, Kenta; Kawazoe, Yoshiyuki; Yasuhara, Hiroshi

    2010-10-28

    A unified interpretation of Hund's first and second rules for 2p (C, N, O) and 3p (Si, P, S) atoms is given by Hartree-Fock (HF) and multiconfiguration Hartree-Fock (MCHF) methods. Both methods exactly satisfy the virial theorem, in principle, which enables one to analyze individual components of the total energy E(=T+V(en)+V(ee)), where T, V(en), and V(ee) are the kinetic, the electron-nucleus attraction, and the electron-electron repulsion energies, respectively. The correct interpretation for each of the two rules can only be achieved under the condition of the virial theorem 2T+V=0 by investigating how V(en) and V(ee) interplay to attain the lower total potential energy V(=V(en)+V(ee)). The stabilization of the more stable states for all the 2p and 3p atoms is ascribed to a greater V(en) that is caused by contraction of the valence orbitals accompanied with slight expansion of the core orbitals. The contraction of the valence orbitals for the two rules is a consequence of reducing the Hartree screening of the nucleus at short interelectronic distances. The reduced screening in the first rule is due to a greater amount of Fermi hole contributions in the state with the highest total spin-angular momentum S. The reduced screening in the second rule is due to the fact that two valence electrons are more likely to be on opposite sides of the nucleus in the state with the highest total orbital-angular momentum L. For each of the two rules, the inclusion of correlation does not qualitatively change the HF interpretation, but HF overestimates the energy difference ∣ΔE∣ between two levels being compared. The magnitude of the correlation energy is significantly larger for the lower L states than for the higher L states since two valence electrons in the lower L states are less likely to be on opposite sides of the nucleus. The MCHF evaluation of ∣ΔE∣ is in excellent agreement with experiment. The present HF and MCHF calculations demonstrate the above statements

  6. Electron impact excitation of 2p and 3p states of hydrogen at intermediate energies

    A coupled-channel-optical (CCO) calculation with 9 and 12 atomic states supplemented with the continuum optical potentials for the stronger coupling channels has been performed for the electron impact excitation of hydrogen. The calculated n = 2 and n = 3 differential cross sections and the reduced Stokes parameters are comparable with the state-of-the art calculations. There is closer agreement between the present calculations and the experimental measurements for the reduced Stokes parameters P-bar1 and P-bar3 in the n = 2p excitation at 54.4 eV. The present CCO calculations also display good accord with the limited experimental data for the reduced Stokes parameters in the n = 3p excitation. (authors)

  7. Influence of relaxation effects on probabilities of the 2s2p3 S2—2s2 2p2 3p1,2intercombination

    袁萍; 刘欣生; 等

    2003-01-01

    Transition probabilities of the 2s2p3 5S2-2s2 2P2 3P1,2 intercombination transitions in NII have been calculated by using a large-scale multiconfiguration Dirac-Fock method.In the calculation themost important effects of relativity,correlation,and relaxation are considered.From the calculated transition probabilities,the lifetime of the s22p3 5S2 metastable state is derived.The result is in excellent agreement agreement with the latest experimental result.In the meantime the influence of anomalously strong relaxation effects on probabilities of the 2s2p3 5S2-2s2 2p2 3P1,2 lines in NII have been found.

  8. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    Carette, Thomas; Nemouchi, Messaoud; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are op...

  9. Transition probabilities for the 3s2 3p(2P0)-3s3p2(4P) intersystem lines of Si II

    Calamai, Anthony G.; Smith, Peter L.; Bergeson, S. D.

    1993-01-01

    Intensity ratios of lines of the spin-changing 'intersystem' multiplet of S II (4P yields 2P0) at 234 nm have been used to determine electron densities and temperatures in a variety of astrophysical environments. However, the accuracy of these diagnostic calculations have been limited by uncertainties associated with the available atomic data. We report the first laboratory measurement, using an ion-trapping technique, of the radiative lifetimes of the three metastable levels of the 3s3p2 4P term of Si II. Our results are 104 +/- 16, 406 +/- 33, and 811 +/- 77 micro-s for lifetimes of the J = 1/2, 5/2, and 3/2 levels, respectively. A-values were derived from our lifetimes by use of measured branching fractions. Our A-values, which differ from calculated values by 30 percent or more, should give better agreement between modeled and observed Si II line ratios.

  10. Strong decays of χ{sub cJ}(2P) and χ{sub cJ}(3P)

    Wang, Hui; Ping, Jialun [Nanjing Normal University and Jiangsu Key Laboratory for Numerical Simulation of Large Scale Complex Systems, Department of Physics, Nanjing (China); Yang, Youchang [Zunyi Normal College, Department of Physics, Zunyi (China)

    2014-04-15

    In the framework of the chiral quark model, the mass spectrum of χ{sub cJ}(J = 0, 1, 2, n = 1, 2, 3) is studied with the Gaussian expansion method. Using the wave functions obtained in the study of mass spectrum, the open charm two-body strong decay widths of these states are calculated by using the {sup 3}P{sub 0} model. The results show that the masses of χ{sub cJ}(1P) and χ{sub c2}(2P) are consistent with the experimental data. But the strong decay width of χ{sub c2}(2P) is three times that of the experimental value. The decay width of χ{sub c1}(2P) is sensitive to its mass. In the quark-antiquark picture, the width is about 385 MeV. However, if the channel coupling effects shift its mass to 3872 MeV, its decay width will be around 1 MeV. The possibility of assigning the state X(3872) as χ{sub c1}(2P) cannot be excluded. To assign X(3915) as χ{sub c0}(2P) is disfavored, due to the unmatching of decay channel. For the χ{sub cJ}(3P) states, no states have been assigned. The possible candidates of χ{sub c0}(3P) are X(4160) and X(4140). Their masses are close to the theoretical ones. The experimental branching ratio of X(4160), Γ (X(4160) → D anti D)/Γ (X(4160) → D* anti D*) < 0.09 is compatible with that of χ{sub c0}(3P), 0.07. However the broad decay width of X(4160) cannot be explained by the open charm two-body decay. To assign X(4140) as χ{sub c0}(3P) is also possible, due to the compatibility of the total decay width, the further measurement of decay modes of X(4140) are expected to justify the assignment. (orig.)

  11. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    Carette, Thomas; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are optimized using the Dirac-Coulomb Hamiltonian with correlation models inspired by the non relativistic calculations. Higher-order excitations are captured through multireference configuration interaction calculations including the Breit interaction. In a third (intermediate) approach, the Dirac-Coulomb-Breit Hamiltonian matrix is diagonalized in a relativistic configuration space built with non relativistic MCHF radial functions converted into Dirac spinors using the Pauli approximation. The magnetic dipole hyperfine struct...

  12. (2p/sup 2/)/sup 3/P state of H/sup -/ and the convergence of the CI series

    Jauregui, R.; Bunge, C.F.

    1979-12-01

    A sequence of increasingly accurate configuration interaction (CI) wave functions is used to discuss binding and the convergence of the CI series for the (2p/sup 2/)/sup 3/P state of H/sup -/. We get an upper bound energy E/sub u/=-0.1 253 547 166 a.u.(H), the lowest yet obtained, lying within an estimated 0.4 ..mu..hartree from the exact eigenvalue of Schroedinger's nonrelativistic equation. The angular energy limits define angular energy increments ..delta..E/sub l/ which follows the formula ..delta..E/sub l/approx. =0.18 (l+1/2)/sup -7/a.u. for l> or =4. Five or eighty per cent of binding is obtained with a three-term Psi=c/sub 1/(2p)/sup 2/+c/sub 2/(2p')/sup 2/+c/sub 3/ (3d)/sup 2/ depending on whether the 2p,2p', and 3d orbitals are energy optimized STO's or accurate natural orbitals, respectively.

  13. Measurement of the photoionization cross-section of the 3p{sup 2}P{sub 1/2,3/2} excited levels of sodium

    Amin, N.; Mahmood, S.; Anwar-ul-Haq, M.; Riaz, M.; Baig, M.A. [Quaid-i-Azam Univ., Atomic and Molecular Physics Lab., Dept. of Physics, Islamabad (Pakistan)

    2006-01-15

    The photoionization cross-section and number density of the 3p{sup 2}P(1/2,3/2) excited levels of sodium have been measured as a function of the laser energy using two-step laser excitation in conjunction with a thermionic diode working in the space charge limited mode. Employing the saturation technique, the cross-sections for the 3p{sup 2}P(1/2) and 3p{sup 2}P(3/2) levels are determined as 2.16 (43) Mb and 3.74 (74) Mb respectively. (authors)

  14. 2s 2p 3P10 → 2s21S0 intercombination line in beryllium-like krypton, molybdenum and tungsten

    Transition probabilities are evaluated for the 2s 2p 3P10 → 2s21S0 transition in beryllium-like ions for krypton, molybdenum and tungsten, using configuration-interaction wavefunctions. The importance of the 2s 3p 1P10 configuration is considered

  15. Calculation of the photo-electrons angular distribution asymmetry parameter β2p near the (3s3p)Ip resonance of He

    Near the (3s3p)1p resonance of He, we have calculated the photo-electrons angular distribution asymmetry parameter β2p in the diagonalization approximation. Using the measured value of βn=2 near the (3s3p)1p level obtained by Lindle et al. in the resonance photo-ionization of He to He+(n=2), we have estimated the ratio R=σ2p/σ2s of the partial 2p photo-ionization cross section to the partial 2s photo-ionization cross section. Our calculation supports the result that in the resonance region, the formation of ions in the 2p level dominates over the 2s level. This is in good agreement with the experimental and most of the theoretical results reported to date. (author). 18 refs, 1 fig., 2 tabs

  16. Transition probabilities for the 1s21S0-1s2p 3P1 intercombination line in He-like carbon and nitrogen

    Lifetime measurements are presented for 1s2p 3Psub(1,2) levels for He-like C V and N VI. From the measured lifetimes, transition probabilities are deduced for both allowed and spin-forbidden transitions. The values for the 1s21S0 - 1s2p 3P1 transition rates, 0.29 . 108 and 1.38 . 108 s-1 for C V and N VI respectively, are found to be in good agreement with theory. (orig.)

  17. Electron correlation effects on the hyperfine induced 47Ti18+ (2s2p 3P0 → 2s21S0) transition probability

    We calculated the hyperfine induced transition probability for 47Ti18+ (2s2p 3P0 → 2s21S0) and analysed the influence of the electron correlation effects in order to interpret the reason for a large difference between existing experimental value and previous only one theoretical result with neglected electron correlation effects. An improved result AHFI=0.3708 s-1 was obtained. (author)

  18. Measurement of the 1s2s 1S0-1s2p 3P1 intercombination interval in helium-like silicon.

    Redshaw, M; Myers, E G

    2002-01-14

    Using Doppler-tuned fast-beam laser spectroscopy the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ has been measured to be 7230.5(2) cm(-1). The experiment made use of a single-frequency Nd:YAG (1.319 microm) laser and a high-finesse optical buildup cavity. The result provides a precision test of modern relativistic and QED atomic theory. PMID:11801009

  19. Delayed emission of 2p-1s and 3p-1s X-rays from 40 MeV neon ions ionized in a thin carbon foil

    A previous study of the He- and H-like lines of 40 MeV Ne projectiles excited by a thin carbon foil showed that the x-ray spectrum contains only He-like and H-like lines and that the intensities of these lines are sufficient to employ a high resolution curved crystal spectrometer to study the decay curves for individual transitions. Presented are Ne K x-ray spectra excited by passing a beam of 40 MeV ions through a 50 μg/cm2 carbon foil. They were taken at 0, 2.3, and 9.1 mm behind the foil and are normalized to the same total integrated charge in the carbon foil. The 1s2p(23P1)-1s2(11S0) transition is a spin-forbidden, metastable, intercombination line and has a lifetime of 1.85 x 10-10 sec8, whereas the He-like 1s2p(1P)-1s2(1S), H-like 2p(2P)-1s(2S), and H-like 3p(2P)-1s(2s) transitions are dipole-allowed with lifetimes of 1.13 x 10-13 sec8, 1.59 x 10-13 sec9, and 5.98 x 10-13 sec 10, respectively. It is apparent that even at 1 cm (i.e. 0.5 ns) behind the foil, considerable intensity is still detected for the short lifetime transitions indicating that electrons are cascading from very high n levels. Previous measurements and calculations have shown that the decay curves can be described by a power law of the form I = ct/sup -b/, where c and b are constants for a given line. It has been found that b depends on the initial n,l distribution. The measured decay curves for the delayed He-Like 1s2p(1P)-1s2(1S), H-like 2p-1s and H-like 3p-1s transitions are shown fitted to this power law

  20. Calculation of Electron-Impact 2s22p4 3P2p33s3SO Transition in Atomic Oxygen

    WANG Yang; LI Yan-Hua; ZHOU Ya-Jun

    2005-01-01

    The inelastic scattering of electron from oxygen for the 2s22p4 3P2p33s 3SO transition is studied using the momentum-space coupled channel optical method at 15, 17.5, 20, 22.5, 25, 27.5, 30, 50, and 100eV. Direct ionization cross sections, i.e. differential and integral cross sections, are reported. Important continuum states are included in the coupled channel calculation via a complex equivalent-local optical potential. The present results are compared with the available experimental data and other theoretical calculation results.

  1. Interference effect involving doubly excited states [1s2p](3,1P)3p2 (J=1) in 1s photoionization of neon

    Within the framework of multiconfiguration Dirac-Fock (MCDF) method, the interference between photoionization and photoexcitation autoionization involving the doubly excited states [1s2p](3,1P)3p2 (J=1) of neon have been studied theoretically. The present results indicate the fine structure of the interference spectra in experiment and show the dominant contribution to the total profile resulting from some individual resonances. Reasonable agreement is found between the present calculations and other available theoretical and experimental results. In addition, some interesting trends of variation of Fano parameters q and ρ2 have also been pointed out. (author)

  2. Note on the 2s21So-2s2p 3P1 intercombination line of B II and C III

    Revised transition rates are reported for the 2s21S0-2s2p 3P1 intercombination line of 10.27 ± 0.20 s-1 for B II and 103.0 ± 0.4 s-1 for C III. These MCHF values are based on calculations that correct an error in the spin-other-orbit interaction of previous results and apply the most recent techniques for normalizing Breit-Pauli results for intercombination lines and estimating uncertainties. (orig.)

  3. Improved measurement of the 1s2s 1S0-1s2p 3P1 interval in heliumlike silicon.

    DeVore, Thomas R; Crosby, David N; Myers, Edmund G

    2008-06-20

    Using colinear fast-beam laser spectroscopy with copropagating and counter-propagating beams we have measured the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ with the result 7230.585(6) cm{-1}. The experiment made use of a dual-wavelength, high-finesse, power build-up cavity excited by single-frequency lasers at 1319 and 1450 nm. The result will provide a precision test of ab initio relativistic many-body atomic theory at moderate Z. PMID:18643579

  4. Cross sections for electron capture and excitation in proton collisions with the metastable Be(2s2p3P) atom

    Previous studies have shown that it appears that the metastable Be(1s22s2p 3P) atoms can constitute a significant fraction of the atomic beryllium in the ITER plasma edge. The two-center atomic orbital close-coupling method is employed to study electron capture and excitation processes in proton collisions with the metastable Be(1s22s2p 3P) atom. The interaction of the active electron with the Be+ ion core is represented by a model potential reproducing accurately (to within 3.5%) the energies of triplet excited states Be(1s22snl 3L) (at least up to n = 7). The excitation and state-selective electron capture cross sections up to the n = 5 shells of both centers are calculated in the energy range 1-200 keV/u using an expansion basis involving all the states with n ≤ 7 on H and all triplet states with n ≤ 7 on Be, augmented with a number of pseudo-states. In the energy region below ∼ 10 keV/u, the cross sections of both processes exhibit oscillatory structures, resulting from the multi-state coupling accounted for in the dynamical model. It has been found that the magnitude of excitation cross sections above ∼ 10 keV/u is dominated by the multipole interactions, while below this energy the excitation process proceeds through intermediate electron capture states

  5. Fully numerical complex-coordinate Hartree-Fock calculations for the He 2s2p 1,3P degree autodetaching states

    A fully numerical multiconfiguration Hartree-Fock program has been modified for performance of calculations on atomic quasibound states using the complex-coordinate (complex dilation) technique. We present results of a lowest-order calculation of the 2s2p 1,3P degree autodetaching states of He using this method, and we examine the dilational stability of our calculations. Because the numerical method exhibits a high degree of dilational stability, we need not perform auxiliary calculations to stabilize the energy with respect to the dilation parameter, as is necessary in most basis-set calculations. We also report some small-scale multiconfiguration calculations in which we account for correlation in the closed channels but attempt no improvement of the open-channel part of the wave function. As the closed-channel space is enlarged, our results show a variational collapse of the width similar to (but more pronounced than) that observed in early basis-set studies using the dilation method. The resonance position, on the other hand, is well behaved and appears to be converging to agreement with established values

  6. Large-scale relativistic configuration-interaction calculation of the 2s21S0--2s2p 3P1 intercombination transition in C III

    A large-scale, relativistic configuration-interaction (RCI) method has been developed for precision calculations of transition oscillator strengths. It is based on the no-pair Hamiltonian and employs finite B-spline basis functions. For the 2s21S0--2s2p 3P1 intercombination transition in berylliumlike carbon, the present RCI expansions reach close to 200 000 configurations, and include all single and double excitations from valence-valence, core-valence, and core-core interactions, along with dominant triple and quadruple excitations. Resulting length- and velocity-gauge transition rates are very well converged, but still differ by a factor of 2. This strong gauge dependence is found to arise from the neglect of negative-energy states which has negligible effects on length-gauge results but can affect velocity-gauge results significantly. The present intercombination transition rate for C III of 101.6±0.7 sec-1 differs from the measured value of 102.94±0.14 sec-1 [Doerfert , Phys. Rev. Lett. 78, 4355 (1997)] by about 1.3%

  7. Theoretical study of Na(4p2P)+Na(3s2S) and Cd(5p3P0)+Na(3s2S) collisions and their role in the energy transfer between Cd* and Na

    We have computed the cross sections for the energy transfer process Cd(5p3P0) + Na(3s2S) →Cd(5s1S) + Na(4p2P) and for the state changing collision Na(4p2P) + Na(3s2S)→Na(3d2D) + Na(3s2S), based on theoretical interaction potentials for the NaCd and Na2 systems, respectively. Our calculations shed light on the interpretation of experiments with laser excited Na+Cd vapour mixtures. It turns out that Cd(5p3P0), in rapid equilibrium with the doorway state Cd(5p3P1), efficiently transfers energy to Na, populating the 4p2P state. The collisions with ground state Na cause a very fast conversion of the 4p2P to the 3d2D state, from which the strongest emission is observed. (orig.)

  8. Numerical investigation of NeI for 2p55g configuration and ArI for 3p55g configuration Zeeman structure

    Full text: The behavior of an atom in the magnetic field can be studied numerically based on the parameters of the fine structure (the radial integrals in the energy operator matrix). A set of the fine structure parameters ensuring the correlation with experimentally observed energies was obtained in the previous works of the authors. The authors provide the results of the numerical study of magnetic sublevels behavior for NeI and ArI (of specified configurations) in the magnetic fields up to 150 kOe. Using the free momentums representation and the Clebsch-Gordan coefficients the authors succeeded to obtain the expressions for the diagonal and non-diagonal elements of the atom-field interaction matrices in LSJM-representation as well as to refine the signs of the non-diagonal elements. (γψi|W|γψi) = (((J(J + 1) + L(L + 1) - S (S +1)/2J(J + 1))gl + ((J(J + 1) - L(L + 1) + S (S +1)/2J(J + 1))gs)) μ0H M (ΔJ 0 ΔL = ΔS = 0 ; (γψi|W|γ'ψj) √[((J - L + S + 1)(J + L - S + 1)(J + L + S + 2)(L + S - J))/4(J + 1)2(2J + 1)(2J + 3) x ((J + 1)2 - M2 x (gl - gs)μ0H] (ΔJ 0 ±1, ΔL ΔS = 0, Jmin). The energies of Zeeman's sublevels were calculated by means of the diagonalization of the complete energy operator matrix, which was expressed in LS-representation with additional elements accounting for the atom-field interaction. The diagonalization was carried out for all the values of the magnetic quantum number M. The distinctive details of Zeemann's structure especially points of crossing and anticrossing areas of magnetic sublevels were obtained for 2p55g configuration of NeI and 3p55g configuration of ArI. (author)

  9. Electron Excitation Cross Sections for the S II Transitions: 3s(exp 2)3p(exp 3) 4S(exp o) approaches 3s(exp 2)3p(exp 3) 2D(exp o), 2P(exp o), and 3s3p(exp 4) 4P

    Liao, C.; Chutjian, A.; Hitz, D.; Tayal, S. S.

    1997-01-01

    Experimental and theoretical collisional excitation cross sections are reported for the transitions 3s(exp 2)3p(exp 3)4S(exp o) approaches 3s(exp 2)3p(exp 3) 2D(exp o), 2P(exp o), and 3s3P(exp 4) 4P in S II. The transition wavelengths (energies) are 6716 A (1.85 eV), 4069 A (3.05 eV), and 1256 A (9.87 eV), respectively. In the experiments, use is made of the energy-loss merged-beams method. The metastable fraction of the S II beam was assessed and minimized. The contribution of elastically scattered electrons was reduced by the use of a lowered solenoidal magnetic field and a modulated radio-frequency voltage on the analyzing plates and by retarding grids to reject the elastically scattered electrons with larger Larmor radii. For each transition, comparisons are made among experiments, the new 19 state R-matrix calculation, and three other close-coupling calculations.

  10. Atomic parameters for the 2{p}^{5}3p\\;{}^{2}{[3/2]}_{2}-2{p}^{5}3s\\;{}^{2}{[3/2]}_{2}^{o} transition of Ne I relevant in nuclear physics

    Li, Jiguang; Godefroid, Michel; Wang, Jianguo

    2016-06-01

    We calculated the magnetic dipole hyperfine interaction constants and the electric field gradients of 2{p}53p{}2{[3/2]}2 and 2{p}53s{}2[3/2{]}2o levels of Ne I by using the multiconfiguration Dirac–Hartree–Fock method. The electronic factors contributing to the isotope shifts were also estimated for the λ =614.5 {{nm}} transition connecting these two states. Electron correlation and relativistic effects including the Breit interaction were investigated in detail. Combining with recent measurements, we extracted the nuclear quadrupole moment values for 20Ne and 23Ne with a smaller uncertainty than the current available data. Isotope shifts in the 2{p}53p{}2{[3/2]}2-2{p}53s{}2[3/2{]}2o transition based on the present calculated field- and mass-shift parameters are in good agreement with the experimental values. However, the field shifts in this transition are two or three orders of magnitude smaller than the mass shifts, making rather difficult to deduce changes in nuclear-charge mean-square radii. According to our theoretical predictions, we suggest using instead transitions connecting levels arising from the 2p53s configuration to the ground state, for which the normal mass shift and specific mass shift contributions counteract each other, producing relatively small mass shifts that are only one order of magnitude larger than relatively large field shifts, especially for the 2{p}53s{}2[1/2{]}1o-2{p}6{}1{S}0 transition.

  11. Interaction of Ne(2p54p), Ar(3p54p) and Kr(4p55p) excited atoms with He and Ne atoms. Processes of collisional depolarization

    Quasimolecular terms Ne(2p54p)+He, Ar(3p54p)+He,Ne and Kr(4p55p)+He,Ne are calculated within the framework of one-configuration method of effective Hamiltonian. The results of calculations agree with the experimental data

  12. Influence of relaxation effects on probabilities of the 2s2p3 5s2-2s22p2 3P1,2 intercombination transitionsin NII

    袁萍; 刘欣生; 颉录有; 张义军; 董晨钟

    2003-01-01

    Transition probabilities of the 2s2p3 5S2-2s22p2 3P1,2 intercombination transitions in NII have been calculated by using a large-scale multiconfiguration Dirac-Fock method. In the calculation the most important effects of relativity,correlation, and relaxation are considered. From the calculated transition probabilities, the lifetime of the 2s2p3 5S2metastable state is derived. The result is in excellent agreement with the latest experimental result. In the meantime the influence of anomalously strong relaxation effects on probabilities of the 2s2p3 5S2-2s22p2 3P1,2 lines in NII have been found.

  13. AB173. TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals

    Yang, Guosheng; Qiu, Xiaofo

    2016-01-01

    Objective Testicular nuclear receptor 4 (TR4) is a member of the nuclear receptor superfamily, which may play key roles to influence the metabolic diseases and prostate tumorigenesis. The purpose of our study is to elucidate the mechanisms how TR4 influences the prostate cancer (PCa) metastasis. Methods We constructed three different PCa cell lines including C4-2, PC3 and CWR22Rv1 with differential stable expression of TR4. RT-PCR and Western blot analysis were used to validate identified downstream genes. To explore the function of genes, we manipulated cells 2D and 3D invasion assays and mice experiment. Results we found TR4 could promote PCa cell invasion using two different cell invasion assays. Mechanism dissection revealed that TR4 might enhance PCa cell invasion via modulation of the microRNA-373-3p (miR-373-3p) expression. An interruption approach using miR-373-3p partially reversed TR4-enhanced PCa cell invasion. Furthermore, we found TR4-miR-373-3p might function through modulation of the TGFβR2/p-Smad3 signals to enhance the PCa cell invasion. The in vivo mouse model using orthotopic xenografted CWR22Rv1 cell line transfected with luciferase-reporter also confirmed in vitro cell line studies showing TR4 enhanced PCa metastasis via modulation of miR-373-3p. Conclusions Our data suggest that TR4 may represent a key player to influence the PCa metastasis and targeting TR4 miR-373-3p→ TGFβR2/p-Smad3 axis using TR4 antagonist or TR4-siRNA or miR-373-3p may become a new potential therapeutic approach to better suppress PCa metastasis.

  14. RECENT ADVANCES IN THE 5Q- SYNDROME

    Andrea Pellagatti

    2015-05-01

    Full Text Available The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS and patients with this disorder have a deletion of chromosome 5q [del(5q] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years. Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome. Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. Haploinsufficiency of CSNK1A1 leads to hematopoietic stem cell expansion in mice and may play a role in the initial clonal expansion in patients with 5q- syndrome. Moreover, a subset of patients harbor mutation of the remaining CSNK1A1 allele. Mouse models of the 5q- syndrome, which recapitulate the key features of the human disease, indicate that a p53-dependent mechanism underlies the pathophysiology of this disorder. Importantly, activation of p53 has been demonstrated in the human 5q- syndrome. Recurrent TP53 mutations have been associated with an increased risk of disease evolution and with decreased response to the drug lenalidomide in del(5q MDS patients. Potential new therapeutic agents for del(5q MDS include the translation enhancer L-leucine.

  15. Multiconfigurational-Dirac-Fock calculation of the 2s21S0--2s2p 3P1 spin-forbidden transition for the Be-like isoelectronic sequence

    Accurate ab initio multiconfigurational-Dirac-Fock (MCDF) calculations of the lifetimes of the spin-forbidden 2s21S0--2s2p 3P1 transition and the allowed 2s21S0--2s2p 1P1 transition in Be-like ions have been performed. The importance of the inclusion of the Breit interaction to obtain accurate fine-structure splittings and mixing coefficients is discussed and the noted discrepancy between the length and velocity gauges for the intercombination line in the lighter ions is addressed. Different optimization procedures are evaluated. For C III the experimental intercombination transition rate has been measured to be 121.9 s-1 with an accuracy of 6%. The current calculation gives 100.3±4 s-1, in agreement with other recent calculations

  16. Facile aqueous synthesis and electromagnetic properties of novel 3D urchin-like glass/Ni-Ni(3)P/Co(2)P(2)O(7) core/shell/shell composite hollow structures.

    An, Zhenguo; Zhang, Jingjie; Pan, Shunlong

    2010-04-14

    Novel 3D urchin-like glass/Ni-Ni(3)P/Co(2)P(2)O(7) core/shell/shell composite hollow structures are fabricated for the first time by controlled stepwise assembly of granular Ni-Ni(3)P alloy and ribbon-like Co(2)P(2)O(7) nanocrystals on hollow glass spheres in aqueous solutions at mild conditions. It is found that the shell structure and the overall morphology of the products can be tailored by properly tuning the annealing temperature. The as-obtained composite core/shell/shell products possess low density (ca. 1.18 g cm(-3)) and shape-dependent magnetic and microwave absorbing properties, and thus may have some promising applications in the fields of low-density magnetic materials, microwave absorbers, etc. Based on a series of contrast experiments, the probable formation mechanism of the core/shell/shell hierarchical structures is proposed. This work provides an additional strategy to prepare core/shell composite spheres with tailored shell morphology and electromagnetic properties. PMID:20379530

  17. Photoionization of the Be-like O4+ ion: total and partial cross sections for the ground 2s21S and excited 2s2p 1,3P states

    Photoionization cross sections of the Be-like O4+ ion in the photon energy region from the first threshold up to the O5+ 3d threshold have been calculated using a non-iterative variational R-matrix method combined with multichannel quantum-defect theory for the ground 2s21S and excited 2s2p 1,3P states. The partial cross sections are presented and the autoionizing resonance structures arising from the ground and excited states are identified and characterized. Our calculational results, which show excellent agreement between length and velocity gauges, are compared with the available experiment and previous calculations, and good agreement is found.

  18. Alignment of Ar{sup +} [{sup 3}P]4p{sup 2}P{sup 0}{sub 3/2} satellite state from the polarization analysis of fluorescent radiation after photoionization

    Yenen, O.; McLaughlin, K.W.; Jaecks, D.H. [Univ. of Nebraska, Lincoln, NE (United States)] [and others

    1997-04-01

    The measurement of the polarization of radiation from satellite states of Ar{sup +} formed after the photoionization of Ar provides detailed information about the nature of doubly excited states, magnetic sublevel cross sections and partial wave ratios of the photo-ejected electrons. Since the formation of these satellite states is a weak process, it is necessary to use a high flux beam of incoming photons. In addition, in order to resolve the many narrow doubly excited Ar resonances, the incoming photons must have a high resolution. The characteristics of the beam line 9.0.1 of the Advanced Light Source fulfill these requirements. The authors determined the polarization of 4765 {Angstrom} fluorescence from the Ar{sup +} [{sup 3}P] 4p {sup 2}P{sub 3/2}{sup 0} satellite state formed after photoionization of Ar by photons from the 9.0.1 beam line of ALS in the 35.620-38.261 eV energy range using a resolution of approximately 12,700. This is accomplished by measuring the intensities of the fluorescent light polarized parallel (I{parallel}) and perpendicular (I{perpendicular}) to the polarization axis of the incident synchrotron radiation using a Sterling Optics 105MB polarizing filter. The optical system placed at 90{degrees} with respect to the polarization axis of the incident light had a narrow band interference filter ({delta}{lambda}=0.3 nm) to isolate the fluorescent radiation.

  19. Large-scale relativistic configuration-interaction calculation of the 2s{sup 2} {sup 1}S{sub 0}--2s2p {sup 3}P{sub 1} intercombination transition in C III

    Chen, M. H.; Cheng, K. T.; Johnson, W. R.

    2001-10-01

    A large-scale, relativistic configuration-interaction (RCI) method has been developed for precision calculations of transition oscillator strengths. It is based on the no-pair Hamiltonian and employs finite B-spline basis functions. For the 2s{sup 2} {sup 1}S{sub 0}--2s2p {sup 3}P{sub 1} intercombination transition in berylliumlike carbon, the present RCI expansions reach close to 200 000 configurations, and include all single and double excitations from valence-valence, core-valence, and core-core interactions, along with dominant triple and quadruple excitations. Resulting length- and velocity-gauge transition rates are very well converged, but still differ by a factor of 2. This strong gauge dependence is found to arise from the neglect of negative-energy states which has negligible effects on length-gauge results but can affect velocity-gauge results significantly. The present intercombination transition rate for C III of 101.6{+-}0.7 sec{sup -1} differs from the measured value of 102.94{+-}0.14 sec{sup -1} [Doerfert , Phys. Rev. Lett. 78, 4355 (1997)] by about 1.3%.

  20. Main: 1B5Q [RPSD[Archive

    Full Text Available 1B5Q トウモロコシ Corn Zea mays L. Polyamine Oxidase Precursor Name=Pao; Zea Mays Molecul...EESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD corn_1B5Q.jpg ...

  1. SMA type 2 unrelated to chromosome 5q13.

    Nevo, Y; Kramer, U; Legum, C; Shomrat, R; Fatal, A; Soffer, D; Harel, S; Shapira, Y

    1998-01-13

    We describe two brothers with clinical and histological findings of type 2 spinal muscular atrophy (SMA) associated with small head circumference (protein (NAIP) deletions were detected in these sibs, and they were discordant for the haplotypes determined by DNA markers flanking the 5q13 SMA locus. These findings support the presence of a distinct anterior horn disease unrelated to 5q13. This entity may have either autosomal recessive or X-linked inheritance. PMID:9450884

  2. 3p deletion syndrome.

    Kaur, Anupam; Khetarpal, S

    2013-08-01

    3p deletion is a rare cytogenetic finding. Here we describe a 3 months old male with congenital malformations. His karyotype revealed 3p deletion 46,XY,del(3)(p25-pter). The child had flexion deformity of wrist and elbow which has never been reported before. PMID:24036645

  3. On the kinetic and thermodynamic fragility of the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} bulk metallic glasses

    Gallino, Isabella, E-mail: i.gallino@mx.uni-saarland.de [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Gross, Oliver [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Dalla Fontana, Giulia [Department of Chemistry IFM and NIS, University of Torino, V. Giuria 7, 10125 Torino (Italy); Evenson, Zach; Busch, Ralf [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany)

    2014-12-05

    Highlights: • The studied Pt–Cu–(Ni,Co)–P glasses are more fragile than Zr-based alloys. • They show large increases in the C{sub p} at T{sub g} and small barriers for cooperative rearrangements of atoms. • They have fragility parameters among the lowest reported for BMG systems (D{sup *} = 10–12). • They crystallize into a state that melts with distinctly high entropy of fusion. • The microscopic origin of their fragility seems different than that for Zr- and Pd-based BMGs. - Abstract: The investigations in this study focus on bulk metallic glass (BMG) alloy families based on noble metals like Pt, which are more kinetically fragile than Zr-based BMG systems. Thermophysical properties have been investigated by calorimetry and thermal mechanical analyses for the determination of the specific heat capacity and viscosity, respectively. For the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} BMG compositions consistent Vogel–Fulcher–Tammann (VFT) fits of the viscosity measurements are established, and the temperature dependence of the configurational entropy is calculated from thermodynamic data. Fits to the Adam–Gibbs equation are performed using this configurational entropy change. Their fragile nature is compared to that of Zr-based alloys in terms of structural considerations.

  4. Prenatal detection of 5q14.3 duplication including MEF2C and brain phenotype.

    Cesaretti, Claudia; Spaccini, Luigina; Righini, Andrea; Parazzini, Cecilia; Conte, Giorgio; Crosti, Francesca; Redaelli, Serena; Bulfamante, Gaetano; Avagliano, Laura; Rustico, Mariangela

    2016-05-01

    The 5q14.3 duplication is a rare condition comprising speech and developmental delay, microcephaly, and mild ventriculomegaly. The region 5q14.3 contains several genes but the predominant role for the onset of the neurodevelopmental phenotype has been attributed to MEF2C. We describe the prenatal identification of 5q14.3 duplication, including MEF2C, in a monochorionic twin pregnancy with corpus callosum anomalies, confirmed by autopsy. To the best of our knowledge, this cerebral finding has been observed for the first time in 5q14.3 duplication patients, possibly widening the neurological picture of this scarcely known syndrome. A pathogenetic role of MEF2C overexpression in brain development may be assumed, but further studies are needed. © 2016 Wiley Periodicals, Inc. PMID:26864752

  5. P2P financovanie

    Dobiasová, Dana

    2015-01-01

    The aim of this bachelors thesis is to determine the effect of P2P lending on the economic indicators and the status of small and medium enterprises in the United States, specifically for the period form 2011 to 2015. To better understand the practical part, two first chapters will be focused on defining the concept of P2P lending and analysing the current situation in the United States. Besides that, it is also an emphasis on regulatory requirements which are newly starting to appear. This k...

  6. Saperi P2P

    Salvatore Iaconesi

    2009-10-01

    Full Text Available Il paper presenta l'architettura filosofica e logica di un progetto ongoing per la creazione di un'infrastruttura peer to peer per la diffusione dei saperi. Tale infrastruttura p2p vuole essere la base per costruire un framework aperto e orizzontale, che ospiti pratiche innovative di creazione, condivisione e disseminazione di informazioni e conoscenza.

  7. A family with an inverted tandem duplication 5q22.1q23.2.

    Schmidt, T; Bartels, I; Liehr, T; Burfeind, P; Zoll, B; Shoukier, M

    2013-01-01

    Here, we report a 3-year-old boy with short stature, developmental delay and mild facial dysmorphic signs. Karyotype analysis and array-CGH revealed a pure duplication 5q22.1q23.2 with a length of 14.25 Mb. As demonstrated by multicolor-fluorescence in situ hybridization, the duplicated segment was orientated in an inverted tandem manner. One of the 2 older half-brothers of the index patient was intellectually disabled and showed short stature as well. The mother of the siblings was only 149 cm in height. The affected half-brother as well as the mother of the siblings were tested positive for the same duplication. Duplications of the long arm of chromosome 5 are rare. There are 16 reported cases of different 5q segments with a pure duplication and no additional chromosomal imbalance. In order to refine the 5q-duplication phenotype, reported cases were recently classified in 3 groups on the basis of clinical findings and the involved chromosome segments. However, our case does not fit in any of these groups but is placed in the interjacent chromosomal area between 2 of these groups. Overall, this is the second reported family with a duplication of 5q22.1q23.2 and both families share phenotypic features like short stature, facial dysmorphic signs and speech delay. The reported family provides further information for delineating phenotype-genotype correlations of pure duplications of the 5q region. PMID:23051634

  8. Transition probability values of the 1s22s3p 3P0 level in Be-like ions

    Transition probability values from the 1s22s3p 3P0 level for selected beryllium-like ions, from Z = 5 to 92, are calculated using the multi-configuration Dirac–Fock method including QED corrections, and full correlation up to the 4f subshell in both initial and final levels, for 1s22s3s 3S1, 1s22s2p 3P2 level and 1s22p23P1 decay modes of this level. (paper)

  9. Duplication of 5q21 in a mildly retarded male and his non-retarded mother

    Stallard, R.; Zurcher, V.; Schwartz, S. [Case Western Reserve Univ., Cleveland, OH (United States)

    1994-09-01

    Euchromatic autosomal additions to chromosomal complements are typically associated with global effects including mental retardation (MR) and dysmorphism. We report a familial duplication that does not appear to cause consistent, significant effects. A hyperactive male with mild MR was referred for fra(X) testing at 8 yrs. His karyotype was fra(X) negative and normal except for an addition in one 5q. The abnormal 5 was also in the maternal karyotype, but all other parental chromosomes were normal. The addition (=8.5% the length of a 5) was interpreted as a duplication of band 5q21. FISH with Coatasome 5 (Oncor) showed the addition was from 5. The proband`s karyotype was designated 46,XY,dup(5)(q15q22.1)mat; his mother`s, 46,XX,dup(5)(q15q22.1). Single copy probes are being used to test the cytogenetic interpretation. At 39 yrs, the non-retarded, somewhat inattentive mother, who has a high school diploma and subsequent secretarial courses, cares for the proband and his chromosomally normal, but learning disabled sister at home. The family situation is chaotic with reported paternal psychiatric illness and abuse of the proband and his sister. The mother`s father is dead, but her four younger siblings and mother are reportedly normal. Their chromosomes have not been available. The proband was born at 40 weeks following an uneventful pregnancy, with length and weight at the 5-10th centiles. He walked and talked at about one year. At 9 yrs, his ht/wt ratio was 10th centile. Foot length as <3rd centile; soft masses were present on the anterior ankles. He was otherwise physically normal. His estimated I.Q. was 75 and he was severely hyperactive despite Ritalin. This is the first report of a familial duplication in 5q; no identical, isolated case is known. Although additional family members need evaluation, the presence of the dup(5q) in the non-retarded mother suggests that it may not be associated with the proband`s MR.

  10. An unusual combination of trisomy 21 and partial trisomy 5q.

    Kim, C J; Chi, J. G.; K. H. Lee; Lee, C. K.; Yoo, M. S.; Paik, Y K

    1992-01-01

    The authors describe a male newborn with multiple congenital anomalies; craniofacial dysmorphism, bilateral cleft palate and lip, ambiguous external genitalia with absence of phallus, ventricular septal defect, agenesis of olfactory bulbs, and presence of small round cells simulating migration defect in the cerebellar white matter. Cytogenetic study demonstrated a chromosomal constitution of 47,XY, +21, +5q. Its pathological significance compared with Down's syndrome and hitherto reported par...

  11. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

    Smith, J. Gustav; Felix, Janine F.; Morrison, Alanna C.; Kalogeropoulos, Andreas; Trompet, Stella; Wilk, Jemma B.; Gidlöf, Olof; Wang, Xinchen; Morley, Michael; Mendelson, Michael; Joehanes, Roby; Ligthart, Symen; Shan, Xiaoyin; Bis, Joshua C.; Wang, Ying A.

    2016-01-01

    Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% i...

  12. Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.

    Ryan, S. G.; Dixon, M J; Nigro, M A; Kelts, K A; Markand, O N; Terry, J C; Shiang, R; Wasmuth, J J; O'Connell, P

    1992-01-01

    Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to sudden, unexpected acoustic or tactile stimuli. STHE responds dramatically to the benzodiazepine drug clonazepam, which acts at gamma-aminobutyric acid type A (GABA-A) receptors. The STHE locus (STHE) was recently assigned to chromosome 5q, on the basis of tight...

  13. Multiconfiguration Hartree-Fock Breit-Pauli results for the 2p 2P/sub 1/2/ - 2p 2P/sub 3/2/ E2 and M1 transitions

    Some forbidden transitions become possible through the fine structure splitting of an LS term into a series of J levels. Examples are the E2 and M1 transition between the 2p 2P/sub 1/2/ and 2p 2P/sub 3/2/ levels in the boron sequence. In the non-relativistic approximation, these levels are degenerate and there is a strong interaction between the 2s22p and 2p32P configurations, indicating important correlation efforts. Thus the theoretical determination of the fine structure splitting provides a sensitive test for a computational method. The MCHF method has been extended to include the relativistic corrections in the Breit-Pauli approximation. An MCHF-BP calculation proceeds in two stages. In the first, a non-relativistic MCHF calculation is performed to determine an orbital basis, whereas in the second the Breit-Pauli interaction matrix is diagonalized. At present the orbit-orbit interactions are neglected. Calculations have been performed with this method for 2p 2P/sub 1/2/ - 2p 2P/sub 3/2/ E2 and M1 transitions of the boron sequence. In order to study the effect of correlation outside the n = 2 complex, two sets of calculations were performed. In the first, the radial orbitals were determined for an MCHF calculation for (2s22p, 2p3) 2P and the Breit-Pauli diagonalization was over the set of four configuration states, (2s22p, 2p32P, 2p32D and 2p34S). In the second, the MCHF calculation was for [2s22p, 2p3, 2p2(1S)3p, 2s24p, 2s2p(1,3P) 3d, 2s3s(3S) 2p] 2P and the Breit-Pauli diagonalization included twenty 2P configuration states, as well as 2p32D and 2p34S, for a total of twenty-two configuration states

  14. Bilateral radial agenesis with absent thumbs, complex heart defect, short stature, and facial dysmorphism in a patient with pure distal microduplication of 5q35.2-5q35.3

    Jamsheer Aleksander

    2013-01-01

    Full Text Available Abstract Background A partial duplication of the distal long arm of chromosome 5 (5q35-- > qter is known to be associated with a distinct phenotype referred to as Hunter-McAlpine syndrome. Clinical spectrum of this disorder mainly consists of mental retardation, microcephaly, short stature, skeletal anomalies, and craniofacial dysmorphism featuring flat facies, micrognathia, large, low-set dysplastic ears, hypertelorism, almond-shaped, down-slanted palpebral fissures, epicanthal folds, small nose, long philtrum, small mouth, and thin upper lip. Less frequent remarkable findings include craniosynostosis, heart defect, hypoplastic phalanges, preaxial polydactyly, hypospadias, cryptorchidism, and inguinal hernia. In most patients with a partial duplication of 5q the aberration occurred due to an inherited unbalanced translocation, therefore the phenotype was not reflective of pure trisomy 5q. Case presentation We report on a 9.5-year-old boy with some feature of Hunter-McAlpine syndrome including short stature, complex heart defect (dextrocardia, dextroversion, PFO, bilateral cryptorchidism, hypothyroidism, and craniofacial dysmorphism. Additionally, bilateral radial agenesis with complete absence of Ist digital rays, ulnar hypoplasia with bowing, choroidal and retinal coloboma, abnormal biliary vesicle were identified, which have never been noted in 5q trisomy patients. Karyotype analysis, sequencing and MLPA for TBX5 and SALL4 genes were unremarkable. Array comparative genomic hybridization detected a duplication on 5q35.2-5q35.3, resulting from a de novo chromosomal rearrangement. Our proband carried the smallest of all previously reported pure distal 5q trisomies encompassing terminal 5.4-5.6 Mb and presented with the most severe limb malformation attributed to the increased number of distal 5q copies. Conclusions We postulate that a terminal distal trisomy of 5q35.2-5q35.3, which maps 1.1 Mb telomeric to the MSX2 gene is causative for both

  15. Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q

    Ryan, S.G.; O' Connell, P. (Univ. of Texas Health Science Center, San Antonio (United States)); Dixon, M.J. (Univ. of Manchester (United Kingdom)); Nigro, M.A. (Wayne State Univ., Detroit, MI (United States)); Kelts, K.A. (Black Hills Neurology, Rapid City, SD (United States)); Markand, O.N. (Indiana Univ., Indianopolis (United States)); Shiang, R.; Wasmuth, J.J. (Univ. of California, Irvine (United States)); Terry, J.C.

    1992-12-01

    Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to sudden, unexpected acoustic or tactile stimuli. STHE responds dramatically to the benzodiazepine drug clonazepam, which acts at gamma-aminobutyric acid type A (GABA-A) receptors. The STHE locus (STHE) was recently assigned to chromosome 5q, on the basis of tight linkage to the colony-stimulating factor 1-receptor (CSF1-R) locus in a single large family. The authors performed linkage analysis in the original and three additional STHE pedigrees with eight chromosome 5q microsatellite markers and placed several of the most closely linked markers on an existing radiation hybrid (RH) map of the region. The results provide strong evidence for genetic locus homogeneity and assign STHE to a 5.9-cM interval defined by CSF1-R and D5S379, which are separated by an RH map distance of 74 centirays (roughly 2.2-3.7 Mb). Two polymorphic markers (D5S119 and D5S209) lie within this region, but they could not be ordered with respect to STHE. RH mapping eliminated the candidate genes GABRA1 and GABRG2, which encode GABA-A receptor components, by showing that they are telomeric to the target region. 45 refs., 4 figs., 4 tabs.

  16. Configuration interaction calculations of positron binding to Be(3P )

    The configuration interaction method is applied to investigate the possibility of positron binding to the metastable beryllium (1s22s2p 3P ) state. The largest calculation obtained an estimated energy that was unstable by 0.00014 Hartree with respect to the Ps + Be+(2s) lowest dissociation channel. It is likely that positron binding to parent states with non-zero angular momentum is inhibited by centrifugal barriers

  17. Variation in conserved non-coding sequences on chromosome 5q andsusceptibility to asthma and atopy

    Donfack, Joseph; Schneider, Daniel H.; Tan, Zheng; Kurz,Thorsten; Dubchak, Inna; Frazer, Kelly A.; Ober, Carole

    2005-09-10

    Background: Evolutionarily conserved sequences likely havebiological function. Methods: To determine whether variation in conservedsequences in non-coding DNA contributes to risk for human disease, westudied six conserved non-coding elements in the Th2 cytokine cluster onhuman chromosome 5q31 in a large Hutterite pedigree and in samples ofoutbred European American and African American asthma cases and controls.Results: Among six conserved non-coding elements (>100 bp,>70percent identity; human-mouse comparison), we identified one singlenucleotide polymorphism (SNP) in each of two conserved elements and sixSNPs in the flanking regions of three conserved elements. We genotypedour samples for four of these SNPs and an additional three SNPs each inthe IL13 and IL4 genes. While there was only modest evidence forassociation with single SNPs in the Hutterite and European Americansamples (P<0.05), there were highly significant associations inEuropean Americans between asthma and haplotypes comprised of SNPs in theIL4 gene (P<0.001), including a SNP in a conserved non-codingelement. Furthermore, variation in the IL13 gene was strongly associatedwith total IgE (P = 0.00022) and allergic sensitization to mold allergens(P = 0.00076) in the Hutterites, and more modestly associated withsensitization to molds in the European Americans and African Americans (P<0.01). Conclusion: These results indicate that there is overalllittle variation in the conserved non-coding elements on 5q31, butvariation in IL4 and IL13, including possibly one SNP in a conservedelement, influence asthma and atopic phenotypes in diversepopulations.

  18. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

    Smith, J. Gustav; Felix, Janine F.; Morrison, Alanna C.; Trompet, Stella; Wilk, Jemma B.; Gidlöf, Olof; Morley, Michael; Joehanes, Roby; Ligthart, Symen; Shan, Xiaoyin; Bis, Joshua C.; Sjögren, Marketa; Ngwa, Julius; Stott, David J.; Aguilar, David; Rice, Kenneth M.; Sesso, Howard D.; Demissie, Serkalem; Buckley, Brendan M.; Taylor, Kent D.; Ford, Ian; Yao, Chen; Liu, Chunyu; Sotoodehnia, Nona; van der Harst, Pim; Stricker, Bruno H. Ch.; Kritchevsky, Stephen B.; Liu, Yongmei; Gaziano, J. Michael; Hofman, Albert; Moravec, Christine S.; Uitterlinden, André G.; Kellis, Manolis; van Meurs, Joyce B.; Margulies, Kenneth B.; Dehghan, Abbas; Levy, Daniel; Olde, Björn; Psaty, Bruce M.; Cupples, L. Adrienne; Jukema, J. Wouter; Djousse, Luc; Franco, Oscar H.; Boerwinkle, Eric; Boyer, Laurie A.; Newton-Cheh, Christopher; Butler, Javed; Vasan, Ramachandran S.; Cappola, Thomas P.; Smith, Nicholas L.

    2016-01-01

    Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% increased risk of death in subjects with heart failure (rs9885413, P = 2.7x10-9). We provide evidence from reporter gene assays, computational predictions and epigenomic marks that this polymorphism increases activity of an enhancer region active in multiple human tissues. The polymorphism was further reproducibly associated with a DNA methylation signature in whole blood (P = 4.5x10-40) that also associated with allergic sensitization and expression in blood of the cytokine TSLP (P = 1.1x10-4). Knockdown of the transcription factor predicted to bind the enhancer region (NHLH1) in a human cell line (HEK293) expressing NHLH1 resulted in lower TSLP expression. In addition, we observed evidence of recent positive selection acting on the risk allele in populations of African descent. Our findings provide novel genetic leads to factors that influence mortality in patients with heart failure. PMID:27149122

  19. Energy and Auger Widths of Triply Excited 3p3p3p 2po State of Lithium

    苟秉聪; 俞开智

    2003-01-01

    The high-lying triply excited 3p3p3p 2po state of the double hollow lithium atom is studied by using the saddlepoint complex-rotation method. The energy and Auger widths of this resonance are calculated. The relativistic corrections and mass polarization are included. The total Auger width is obtained by coupling the important open channels and summing over the other channels. The oscillator strength is also calculated. The results are compared with other theoretical and experimental data in the literature.

  20. p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

    Saft, L.; Karimi, M.; Ghaderi, M.; Matolcsy, A.; Mufti, G.J.; Kulasekararaj, A.; Gohring, G.; Giagounidis, A.; Selleslag, D.; Muus, P.; Sanz, G.; Mittelman, M.; Bowen, D.; Porwit, A.; Fu, T.; Backstrom, J.; Fenaux, P.; MacBeth, K.J.; Hellstrom-Lindberg, E.

    2014-01-01

    Del(5q) myelodysplastic syndromes defined by the International Prognostic Scoring System as low- or intermediate-1-risk (lower-risk) are considered to have an indolent course; however, recent data have identified a subgroup of these patients with more aggressive disease and poorer outcomes. Using de

  1. Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide

    Sugimoto Yuka

    2012-03-01

    Full Text Available Abstract Background While lenalidomide (LEN shows high efficacy in myelodysplastic syndromes (MDS with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chromosomal abnormalities with new karyotyping tools may better predict response to LEN. Design and methods We have studied clinical, molecular and cytogenetic features of 42 patients with MDS, myeloproliferative neoplasms (MPN, MDS/MPN overlap syndromes and secondary acute myeloid leukemia (sAML without del[5q] by metaphase cytogenetics (MC who underwent therapy with LEN. Results Fluorescence in situ hybridization (FISH or single nucleotide polymorphism array (SNP-A-based karyotyping marginally increased the diagnostic yield over MC, detecting 2/42 (4.8% additional cases with del[5q], one of whom were responded to LEN. Responses were more often observed in patients with a normal karyotype by MC (60% vs abnormal MC; 17%, p = .08 and those with gain of chromosome 8 material by either of all 3 karyotyping methods (83% vs all other chromosomal abnormalities; 44% p = .11. However, 5 out of those 6 patients received combined LEN/AZA therapy and it may also suggest those with gain of chromosome 8 material respond well to AZA. The addition of FISH or SNP-A did not improve the predictive value of normal cytogenetics by MC. Mutational analysis of TET2, UTX, CBL, EZH2, ASXL1, TP53, RAS, IDH1/2, and DNMT-3A was performed on 21 of 41 patients, and revealed 13 mutations in 11 patients, but did not show any molecular markers of responsiveness to LEN. Conclusions Normal karyotype and gain of chromosome 8 material was predictive of response to LEN in non-del[5q] patients with myeloid malignancies.

  2. Measurements of oscillator strengths of the 2p{sup 5}({sup 2}P{sub 1/2})nd J = 2, 3 autoionizing resonances in neon

    Mahmood, Shaukat; Amin, Nasir; Sami-ul-Haq; Shaikh, Nek M; Hussain, Shahid; Baig, M A [Atomic and Molecular Physics Laboratory, Department of Physics, Quaid-i-Azam University, Islamabad 45320 (Pakistan)

    2006-05-14

    Oscillator strengths of the 2p{sup 5}({sup 2}P{sub 1/2})nd J = 2, 3 autoionizing resonances in neon have been determined using a dc discharge plasma in conjunction with an Nd:YAG pumped dye laser system. The excited states are approached using two-step laser excitation via 2p{sup 5}3p'[1/2]{sub 1}, 2p{sup 5}3p'[3/2]{sub 1} and 2p{sup 5}3p'[3/2]{sub 2} intermediate states which are accessed from the 2p{sup 5}3s [1/2]{sub 2} metastable state, populated by the discharge in the hollow cathode lamp. The f-values have been determined for the nd'[3/2]{sub 2}, nd'[5/2]{sub 2} and nd'[5/2]{sub 3} series following the {delta}K = {delta}J = +{delta}l selection rule. Employing the saturation technique the photoionization cross section at the 2p{sup 5} {sup 2}P{sub 1/2} ionization threshold is determined as 5.5(6) Mb and consequently the f-values of the nd' J = 2, 3 autoionizing resonances have been extracted.

  3. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population.

    Loh, E W; Tang, N L S; Lee, D T S; Liu, S I; Stadlin, Alfreda

    2007-06-01

    GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAgamma2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. PMID:17440936

  4. Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease.

    Hodgson, S V; Coonar, A S; P. J. Hanson; Cottrell, S; Scriven, P N; Jones, T; Hawley, P R; Wilkinson, M L

    1993-01-01

    Two cases are reported of patients with deletions of chromosome 5q. Both have familial adenomatous polyposis (FAP) and mild mental retardation. In both, macroscopic polyposis was confined to the proximal colon in adult life (in their thirties) although microscopic adenomatosis was shown in the more distal colon with occasional single polyps. Both subjects had dermoid cysts, and congenital hypertrophy of the retinal pigment epithelium (CHRPE) was seen in case 2. Case 1 has gastroduodenal polyp...

  5. Plasma diagnostic potential of 2p4f in N$^+$ -- accurate wavelengths and oscillator strengths

    Shen, Xiaozhi; Li, Jiguang; Jönsson, Per; Wang, Jianguo

    2015-01-01

    Radiative emission lines from nitrogen and its ions are often observed in nebulae spectra, where the N$^{2+}$ abundance can be inferred from lines of the 2p4f configuration. In addition, intensity ratios between lines of the 2p3p -- 2p3s and 2p4f -- 2p3d transition arrays can serve as temperature diagnostics. To aid abundance determinations and plasma diagnostics, wavelengths and oscillator strengths were calculated with high-precision for electric-dipole (E1) transitions from levels in the 2...

  6. Thermoelastic properties of Zn3P2

    Gerward, Leif; Olsen, J. Staun; Waśkowska, A.

    2011-01-01

    The bulk modulus and thermal expansion of Zn3P2 has been investigated at pressures up to 21GPa and temperatures down to 100K. The experimental zero-pressure bulk modulus is 80.7 ± 1.8GPa, in accordance with the bulk modulus scaling and lattice properties of the related compound Cd3P2. A tetragonal...... to orthorhombic phase transformation occurs above 11GPa with a relative volume change of-7.1%. Values for the thermal expansion coefficient are reported at 293, 200 and 100K....

  7. Collision-induced intramultiplet mixing for the Ne**[(2p)5(3p)] + He or Ne system

    For the Ne**-He case, experimental data are confronted with quantum mechanical calculations. Quantum mechanical coupled-channel calculations using model potentials as input are presented, followed by a semiclassical approach which provides more physical insight. Experimental results are presented for the Ne**-Ne system with a discussion of the general principles involved in symmetrization. 184 refs.; 93 figs.; 19 tabs

  8. Differential measurements on Ne*(2p 53s 3P 0.2)-Ne collisions in the hyperthermal energy range

    Feron, P.; Perales, F.; Decomps, B.; Robert, J.; Reinhardt, J.; Baudon, J.; Haberland, H.

    1989-08-01

    Differential cross sections for collisions of metastable neon atoms with ground state neon atoms have been measured in the energy range 0.247-0.551 eV in a crossed nozzle beam experiment using heating and seeding techniques. At large angle, the cross sections exhibit a rainbow feature due to a hump in the 0 u- and 1 u potentials. The present data are in good agreement with calculations based on potential energy curves deduced from previous experiments at thermal energy.

  9. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

    D.M. Glubb (Dylan); M. Maranian (Melanie); K. Michailidou (Kyriaki); K.A. Pooley (Karen); K.B. Meyer (Kerstin); S. Kar (Siddhartha); A.F.C. Carlebur; M. O'Reilly (Marian); J.A. Betts (Joshua); K.M. Hillman (Kristine); S. Kaufmann (Susanne); J. Beesley (Jonathan); S. Canisius (Sander); J.L. Hopper (John); M.C. Southey (Melissa); H. Tsimiklis (Helen); C. Apicella (Carmel); M.K. Schmidt (Marjanka); A. Broeks (Annegien); F.B.L. Hogervorst (Frans); C.E. van der Schoot (Ellen); K.R. Muir (K.); A. Lophatananon (Artitaya); S. Stewart-Brown (Sarah); P. Siriwanarangsan (Pornthep); P.A. Fasching (Peter); M. Ruebner (Matthias); A.B. Ekici (Arif); M.W. Beckmann (Matthias W.); J. Peto (Julian); I. dos Santos Silva (Isabel); O. Fletcher (Olivia); N. Johnson (Nichola); P.D.P. Pharoah (Paul D.P.); M.K. Bolla (Manjeet); Q. Wang (Qing); J. Dennis (Joe); E.J. Sawyer (Elinor); I.P. Tomlinson (Ian); M. Kerin (Michael); N. Miller (Nicola); B. Burwinkel (Barbara); F. Marme (Federick); R. Yang (Rongxi); H. Surowy (Harald); P. Guénel (Pascal); T. Truong (Thérèse); F. Menegaux (Florence); M. Sanchez (Marie); S.E. Bojesen (Stig); B.G. Nordestgaard (Børge); S.F. Nielsen (Sune); H. Flyger (Henrik); A. González-Neira (Anna); J. Benítez (Javier); M.P. Zamora (Pilar); J.I. Arias Pérez (José Ignacio); H. Anton-Culver (Hoda); S.L. Neuhausen (Susan); H. Brenner (Hermann); A.K. Dieffenbach (Aida Karina); V. Arndt (Volker); C. Stegmaier (Christa); A. Meindl (Alfons); R.K. Schmutzler (Rita); H. Brauch (Hiltrud); Y.-D. Ko (Yon-Dschun); T. Brüning (Thomas); H. Nevanlinna (Heli); T.A. Muranen (Taru); K. Aittomäki (Kristiina); C. Blomqvist (Carl); K. Matsuo (Keitaro); H. Ito (Hidemi); H. Iwata (Hisato); H. Tanaka (Hideo); T. Dörk (Thilo); N.V. Bogdanova (Natalia); S. Helbig (Sonja); A. Lindblom (Annika); S. Margolin (Sara); A. Mannermaa (Arto); V. Kataja (Vesa); V-M. Kosma (Veli-Matti); J.M. Hartikainen (J.); A.H. Wu (Anna H.); C.-C. Tseng (Chiu-Chen); D. Van Den Berg (David); D.O. Stram (Daniel O.); D. Lambrechts (Diether); H. Zhao (Hui); C. Weltens (Caroline); E. van Limbergen (Erik); J. Chang-Claude (Jenny); D. Flesch-Janys (Dieter); A. Rudolph (Anja); P. Seibold (Petra); P. Radice (Paolo); P. Peterlongo (Paolo); M. Barile (Monica); F. Capra (Fabio); F.J. Couch (Fergus); J.E. Olson (Janet); B. Hallberg (Boubou); C. Vachon (Celine); G.G. Giles (Graham); R.L. Milne (Roger); C.A. McLean (Catriona Ann); C.A. Haiman (Christopher); B.E. Henderson (Brian); F.R. Schumacher (Fredrick); L. Le Marchand (Loic); J. Simard (Jacques); M.S. Goldberg (Mark); F. Labrèche (France); M. Dumont (Martine); S.-H. Teo; C.H. Yip (Cheng Har); M.-H. See (Mee-Hoong); B.K. Cornes (Belinda); C.-Y. Cheng (Ching-Yu); M.K. Ikram (Kamran); V. Kristensen (Vessela); W. Zheng (Wei); S.L. Halverson (Sandra L.); M. Shrubsole (Martha); J. Long (Jirong); R. Winqvist (Robert); K. Pykäs (Katri); A. Jukkola-Vuorinen (Arja); S. Kauppila (Saila); I.L. Andrulis (Irene); J.A. Knight (Julia); G. Glendon (Gord); S. Tchatchou (Sandrine); P. Devilee (Peter); R.A.E.M. Tollenaar (Rob); C.M. Seynaeve (Caroline); C.J. van Asperen (Christi); M. García-Closas (Montserrat); J.D. Figueroa (Jonine); S.J. Chanock (Stephen); J. Lissowska (Jolanta); K. Czene (Kamila); D. Klevebring (Daniel); H. Darabi (Hatef); M. Eriksson (Mikael); M.J. Hooning (Maartje); A. Hollestelle (Antoinette); J.W.M. Martens (John W. M.); J.M. Collee (Margriet); P. Hall (Per); J. Li (Jingmei); K. Humphreys (Keith); X.-O. Shu (Xiao-Ou); W. Lu (Wei); Y.-T. Gao (Yu-Tang); H. Cai (Hui); A. Cox (Angela); S.S. Cross (Simon); M.W.R. Reed (Malcolm); W.J. Blot (William); L.B. Signorello (Lisa B.); Q. Cai (Qiuyin); M. Shah (Mitul); M. Ghoussaini (Maya); D. Kang (Daehee); J.-Y. Choi (J.); S.K. Park (Sue); D-Y. Noh (Dong-Young); M. Hartman (Mikael); X. Miao; W.-Y. Lim (Wei-Yen); A. Tang (Anthony); U. Hamann (Ute); D. Torres (Diana); A. Jakubowska (Anna); J. Lubinski (Jan); K. Jaworska (Katarzyna); K. Durda (Katarzyna); S. Sangrajrang (Suleeporn); V. Gaborieau (Valerie); P. Brennan (Paul); J.D. McKay (James); C. Olswold (Curtis); S. Slager (Susan); A.E. Toland (Amanda); D. Yannoukakos (Drakoulis); C-Y. Shen (Chen-Yang); P.-E. Wu (Pei-Ei); J-C. Yu (Jyh-Cherng); M.-F. Hou (Ming-Feng); A.J. Swerdlow (Anthony ); A. Ashworth (Alan); N. Orr (Nick); M. Jones (Michael); G. Pita (G.); M.R. Alonso (M Rosario); N. Álvarez (Nuria); D. Herrero (Daniel); D.C. Tessier (Daniel C.); D. Vincent (Daniel); F. Bacot (Francois); C. Luccarini (Craig); C. Baynes (Caroline); S. Ahmed (Shahana); S. Healey (Sue); M. Brown (Melissa); B.A.J. Ponder (Bruce A.J.); G. Chenevix-Trench (Georgia); D. Thompson (Deborah); S.L. Edwards (Stacey); D.F. Easton (Douglas); A.M. Dunning (Alison); J.D. French (Juliet)

    2015-01-01

    textabstractGenome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer indiv

  10. UNITS IN $F_2D_{2p}$

    Kaur, Kuldeep; Khan, Manju

    2012-01-01

    Let $p$ be an odd prime, $D_{2p}$ be the dihedral group of order 2p, and $F_{2}$ be the finite field with two elements. If * denotes the canonical involution of the group algebra $F_2D_{2p}$, then bicyclic units are unitary units. In this note, we investigate the structure of the group $\\mathcal{B}(F_2D_{2p})$, generated by the bicyclic units of the group algebra $F_2D_{2p}$. Further, we obtain the structure of the unit group $\\mathcal{U}(F_2D_{2p})$ and the unitary subgroup $\\mathcal{U}_*(F_...

  11. Trisomy 2p: Analysis of unusual phenotypic findings

    Lurie, I.W.; Ilyina, H.G.; Gurevich, D.B. [Belorussian Research Institute of Hereditary Disease, Minsk (Russian Federation)] [and others

    1995-01-16

    We present three probands with partial trisomies 2p21-23 due to ins(4;2)(q21;p21p23) pat, 2p23-pter due to t(2;4)(p23;q35)mat, and 2p21-pter due to t(2;11)(p21;q23.3)mat. More than 50 cases of partial trisomy 2p have been reviewed and some abnormalities, unusual for most other types of structural autosomal imbalance, have been found in patients with inherited forms of 2p trisomy and in their non-karyotyped sibs. Neural tube defects (anencephaly, occipital encephalocele, and spina bifida) were found in five probands and 4/6 affected non-karyotyped sibs. The only triplicated segment common to all was 2p24. Different forms of {open_quotes}broncho-pulmonary a/hypoplasia{close_quotes} (including two cases of lung agenesis) were described in four patients (overlapping triplicated segment was 2p21-p25). Three patients (with overlapping triplicated segment 2p23-p25) had diaphragmatic hernia. Abnormal rotation of the heart or L-transposition of large vessels (with or without visceral heterotaxia) was found in two infants (overlapping triplicated segment 2p23-p24). In two patients with common triplicated segment 2p22.3-p25, neuroblastoma has been described. The occurrence of all these defects may be explained either by the action of the same gene(s) mapped to 2p24 or by action of some independent factors located in different segments of the short arm. Although the latter hypothesis is much less probable, it can not be rejected at the present time. We propose the existence of a genetic system controlling surveillance of an abnormal embryo to explain the phenotypic differences between patients with the same imbalance within a family. In some {open_quotes}restrictive{close_quotes} combinations the abnormal embryos will die, although in {open_quotes}permissive{close_quotes} combinations they can survive. 47 refs., 2 figs., 3 tabs.

  12. Towards P2P XML Database Technology

    Zhang, Y.

    2007-01-01

    To ease the development of data-intensive P2P applications, we envision a P2P XML Database Management System (P2P XDBMS) that acts as a database middle-ware, providing a uniform database abstraction on top of a dynamic set of distributed data sources. In this PhD work, we research which features suc

  13. Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

    Tsuchiya Naoyuki

    2009-10-01

    Full Text Available Abstract Background It has been previously demonstrated that a single nucleotide polymorphism (SNP in the IL13 promoter region, IL13 -1055T>C (rs1800925, was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. Methods A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients. Results Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73, showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test. This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032. The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes. Conclusion A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.

  14. TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes.

    McGraw, Kathy L; Cluzeau, Thomas; Sallman, David A; Basiorka, Ashley A; Irvine, Brittany A; Zhang, Ling; Epling-Burnette, P K; Rollison, Dana E; Mallo, Mar; Sokol, Lubomir; Solé, Francesc; Maciejewski, Jaroslaw; List, Alan F

    2015-10-27

    P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients with myelodysplastic syndromes (MDS). Sanger sequencing was performed on DNA isolated from 208 MDS cases. Utilizing a novel functional SNP scoring system ranging from +2 to -2 based on predicted p53 activity, we found statistically significant differences in overall survival (OS) (p = 0.02) and progression-free survival (PFS) (p = 0.02) in non-del(5q) MDS patients with low functional scores. In univariate analysis, only IPSS and the functional SNP score predicted OS and PFS in non-del(5q) patients. In multivariate analysis, the functional SNP score was independent of IPSS for OS and PFS. These data underscore the importance of TP53 R72P and MDM2 SNP309 SNPs in MDS, and provide a novel scoring system independent of IPSS that is predictive for disease outcome. PMID:26416416

  15. Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes

    Giagounidis, Aristoteles; Mufti, Ghulam J.; Fenaux, Pierre; Germing, Ulrich; List, Alan; MacBeth, Kyle J.

    2013-01-01

    Deletion of the long arm of chromosome 5, del(5q), is the most prevalent cytogenetic abnormality in patients with myelodysplastic syndromes (MDS). In isolation, it is traditionally associated with favorable prognosis compared with other subtypes of MDS. However, owing to the inherent heterogeneity of the disease, prognosis for patients with del(5q) MDS is highly variable depending on the presence of factors such as additional chromosomal abnormalities, >5 % blasts in the bone marrow (BM), or ...

  16. $^3P_2$ Superfluids Are Topological

    Mizushima, Takeshi

    2016-01-01

    We clarify the topology of the $^3P_2$ superfluidity which is expected to be realized in the cores of neutron stars and cubic odd-parity superconductors. The phase diagram includes the unitary uniaxial/biaxial nematic phases and nonunitary ferromagnetic and cyclic phases. We here show that the low-energy structures of all the phases are governed by different types of topologically protected gapless fermionic excitations: Surface Majorana fermions in nematic phases, single itinerant Majorana fermion in the ferromagnetic phase, and a quartet of itinerant Majorana fermions in the cyclic phase. Using the superfluid Fermi liquid theory, we also demonstrate that dihedral-two and -four biaxial nematic phases are thermodynamically favored in the weak coupling limit under a magnetic field. The mass acquisition of surface Majorana fermions in nematic phases is subject to symmetry.

  17. Towards P2P XML Database Technology

    Ying ZHANG

    2007-01-01

    To ease the development of data-intensive P2P applications, we envision a P2P XML Database Management System (P2P XDBMS) that acts as a database middle-ware, providing a uniform database abstraction on top of a dynamic set of distributed data sources. In this PhD work, we research which features such a database abstraction should offer and how it can be realised efficiently by extending and combining existing XML databases with P2P technologies. The first step in this research is a distribute...

  18. Propiedad Intelectual y Redes P2P

    ALCAINE SÁNCHEZ, JUAN FRANCISCO

    2015-01-01

    La meta de este documento no es otra que la de presentar al lector información acerca de la legislación sobre propiedad intelectual y distintos protocolos y software P2P. Primero se mostrará información sobre las principales leyes españolas en materia de propiedad intelectual. Posteriormente se presentará información acerca de los principales protocolos P2P sus clientes a lo largo de la historia de las redes P2P. Por último, se mostrarán las alternativas de pago a la descarga no lega...

  19. Plasma diagnostic potential of 2p4f in N$^+$ -- accurate wavelengths and oscillator strengths

    Shen, Xiaozhi; Jönsson, Per; Wang, Jianguo

    2015-01-01

    Radiative emission lines from nitrogen and its ions are often observed in nebulae spectra, where the N$^{2+}$ abundance can be inferred from lines of the 2p4f configuration. In addition, intensity ratios between lines of the 2p3p -- 2p3s and 2p4f -- 2p3d transition arrays can serve as temperature diagnostics. To aid abundance determinations and plasma diagnostics, wavelengths and oscillator strengths were calculated with high-precision for electric-dipole (E1) transitions from levels in the 2p4f configuration of N$^{+}$. Electron correlation and relativistic effects, including the Breit interaction, were systematically taken into account within the framework of the multiconfiguration Dirac-Hartree-Fock (MCDHF) method. Except for the 2p4f - 2p4d transitions with quite large wavelengths and the two-electron-one-photon 2p4f -2s2p$^3$ transitions, the uncertainties of the present calculations were controlled to within 3% and 5% for wavelengths and oscillator strengths, respectively. We also compared our results w...

  20. In patients with myelodysplastic syndromes with del(5q), factors other than age and sex contribute to the prognostic advantage, which diminishes over time.

    Lauseker, Michael; Schemenau, Jennifer; Strupp, Corinna; Kündgen, Andrea; Gattermann, Norbert; Hasford, Joerg; Germing, Ulrich

    2015-09-01

    This study aimed to determine the extent to which the prognostic advantage of myelodysplastic syndromes (MDS) with del(5q) is due to the more favourable age and sex distribution of patients in that group when compared to other MDS subtypes. A total of 1912 MDS patients from the Duesseldorf registry with less than 5% blasts in the bone marrow were evaluable and had complete covariates. As endpoints, overall survival and progression to acute myeloid leukaemia (AML) were considered. Cox models were computed for both outcomes. A multivariate Cox model for survival confirmed higher age and male sex as risk factors. In addition, we found a survival advantage of 9·1 years for MDS del(5q) patients compared to refractory cytopenia with unilineage dysplasia, while the survival advantage of MDS del(5q) over refractory cytopenia with multilineage dysplasia was 18·6 years. Considering progression to AML, we did not find any significant differences between the World Health Organization classification subtypes. Our analyses show that the higher survival probabilities of MDS del(5q) patients are not only due to age and sex, although higher age and male sex were also important risk factors. Interestingly, it seems that the survival advantage of MDS del(5q) decreases over time. PMID:25960152

  1. Electron impact excitation out of the metastable levels of argon into the 3p54p J = 3 level

    We have measured the direct cross section for electron impact excitation out of the metastable 3p54s[3/2]20 level (1s5 in Paschen's notation) into the 3p54p[5/2]3 level (2p9) of argon from threshold to 800 eV. The direct cross section is 40 x 10-16 cm2 at 10 eV. (author)

  2. Irradiation-induced softening of Ni3P and (Ni, Fe, Cr)3P alloys

    Production of amorphous alloys by solid state reactions (SSR) has attracted much interest during the last few years. One of the methods to induce such a reaction is the irradiation of suitable crystalline alloys by fast particles. Examination of this kind of SSR in M3P type of brazing alloys (M: Metal) is attractive because of the following reason: In brazed joints of candidate structural materials like 316L stainless steel for applications in fusion reactors, crystalline intermetallic phases have been detected which are unstable relative to the amorphous state when irradiated at moderate temperatures with fast particles. It is expected that the transition to the amorphous state is accompanied by changes of the mechanical properties, which are of fundamental interest in this context. Until now, only a few studies on the evolution of mechanical properties during amorphization have been performed. Measurements of microhardness of the crystalline and the corresponding amorphous phase do not exist to the authors knowledge. In this communication, the authors present results on changes of microhardness, due to amorphization by fast ions. The measurements have been performed on a model alloy Ni3P and on the brazed joint of stainless steel 316L, containing M3P (M: Ni, Fe, Cr) as one of the phases. Though microhardness is not a fundamental property of materials, it is a manifestation of several related properties, such as yield stress, ductility, work-hardening, elastic modulus and residual stress states. It represents a resistance for indentation and is, therefore, appropriate for comparative purposes

  3. Identification of a novel sarcoglycan gene at 5q33 encoding a sarcolemmal 35 kDa glycoprotein.

    Nigro, V; Piluso, G; Belsito, A; Politano, L; Puca, A A; Papparella, S; Rossi, E; Viglietto, G; Esposito, M G; Abbondanza, C; Medici, N; Molinari, A M; Nigro, G; Puca, G A

    1996-08-01

    Mutations in any of the genes encoding the alpha, beta or gamma-sarcoglycan components of dystrophin-associated glycoproteins result in both sporadic and familial cases of either limb-girdle muscular dystrophy or severe childhood autosomal recessive muscular dystrophy. The collective name 'sarcoglycanopathies' has been proposed for these forms. We report the identification of a fourth member of the human sarcoglycan family. We named this novel cDNA delta-sarcoglycan. Its mRNA expression is abundant in striated and smooth muscles, with a main 8 kb transcript, encoding a predicted basic transmembrane glycoprotein of 290 amino acids. Antibodies specifically raised against this protein recognized a single band at 35 kDa on western blots of human and mouse muscle. Immunohistochemical staining revealed a unique sarcolemmal localization. FISH, radiation hybrid and YAC mapping concordantly linked the delta-sarcoglycan gene to 5q33, close to D5S487 and D5S1439. The gene spans at least 100 kb and is composed of eight exons. The identification of a novel sarcoglycan component modifies the current model of the dystrophin-glycoprotein complex. PMID:8842738

  4. A novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in adult T-cell precursor lymphoblastic leukemia

    Kjeldsen Eigil

    2012-05-01

    Full Text Available Abstract We here describe a novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in a 39-year-old male diagnosed with acute T-cell lymphoblastic leukemia. Bone marrow (BM was massively infiltrated with 85 % highly proliferative polymorphic T-cell precursors. Immunologically, the malignant cells stained positive for CD7, CD34, intracytoplasmic CD3+, TdT + and negative for CD3 and CD5. G-banded chromosome analysis of BM cells showed the normal karyotype 46,XY[25] whereas BAC-based aCGH analysis revealed partial gain of 4q and partial loss of 5q. Multicolor karyotyping confirmed the presence of an unbalanced der(5t(4;5 as the sole structural abnormality. Subsequent high-resolution oligonucleotide-based aCGH analysis showed that the der(5t(4;5(q26;q21.1 resulted in partial trisomy of 4q26qter (117,719,015-190,613,014 and partial monosomy of 5q21.1qter (100,425,442-180,857,866 and that there was no indication of any gene disruptions resulting from the breakages. Interphase FISH analysis using BAC-based specific probes for 4q26 and 5q21.1 confirmed the breakpoints and revealed approximately 80 % abnormal cells accordingly. At 4q26 the MIR1973 gene is located centromeric to the breakpoint in the copy number neutral region and the TRAM1L1 gene is located within the gained region. At 5q21.1 the genes ST8SIA4 and MIR548p are located centromeric to the breakpoint and no known genes up to approximately 1 Mb telomeric to the breakpoint in the copy number loss region. Interestingly, only the gene ST8SIA4 at 5q21.1 have been implicated in T-cell regulation as it encodes one of the key enzymes for polysialysation of surface proteins on dendritic cells which are important regulators for T-cell proliferation. The der(5t(4;5 is thought to play a crucial role in the pathogenesis of acute T-ALL due to either gain of 4q, the loss of 5q, or deregulation of genes in proximity to the breakpoints.

  5. Spectra and oscillator strengths of 3p63d9-3p53d10 and 3p63d9-3p63d84p transitions for cobalt-like Sn23+ ion

    Chen Ming-Lun; Yu Xiao-Guang

    2009-01-01

    This paper calculates the spectra and oscillator strengths for highly ionized cobalt-like Sn23+ ions 3p63d9-3p53d10,3p63d9 - 3p63d84p transitions by using a multi-configuration self-consistent field method program together with the proposed fitting formula. The calculations have a good agreement with observations.

  6. P2P Techniques for Decentralized Applications

    Pacitti, Esther

    2012-01-01

    As an alternative to traditional client-server systems, Peer-to-Peer (P2P) systems provide major advantages in terms of scalability, autonomy and dynamic behavior of peers, and decentralization of control. Thus, they are well suited for large-scale data sharing in distributed environments. Most of the existing P2P approaches for data sharing rely on either structured networks (e.g., DHTs) for efficient indexing, or unstructured networks for ease of deployment, or some combination. However, these approaches have some limitations, such as lack of freedom for data placement in DHTs, and high late

  7. P2P Live Video Streaming

    Chatzidrossos, Ilias

    2010-01-01

    The ever increasing demand for video content directed the focus of researchfrom traditional server-based schemes to peer-to-peer systems for videodelivery. In such systems, video data is delivered to the users by utilizing theresources of the users themselves, leading to a potentially scalable solution.Users connect to each other, forming a p2p overlay network on top of theInternet and exchange the video segments among themselves. The performanceof a p2p system is characterized by its capabil...

  8. Differential cross section of metastable Ne(3P0 and 3P2) scattered from ground state neon

    The differential elastic cross section for metastable Ne(3P0 and 3P2) from ground state Ne at collision energies between 70 and 150 meV have been measured. With a CW-dye laser it was possible to separate the cross sections for Ne(3P0) + Ne and Ne(3P2) + Ne and for the energy exchange process 20Ne* + 22Ne → 20Ne + 22Ne*. (Auth.)

  9. Normal female carrier and affected male half-sibs with t(X;5)(q13;p15). Location of a gene determining male genital development.

    Callen, D F; Sutherland, G R

    1986-07-01

    A unique family in which half-brothers have a maternally derived t(X;5)(q13;p15) and similar genital malformations is described. This family provides evidence for a gene required for male genital development located at Xq13. PMID:3757297

  10. 31 CFR 30.5 - Q-5: How does a TARP recipient comply with the requirements under § 30.4 (Q-4) of this part that...

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Q-5: How does a TARP recipient comply... recipient? 30.5 Section 30.5 Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.5 Q-5: How does a TARP recipient comply with...

  11. Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions

    Mutsaers, H.A.M.; Levtchenko, E.N.; Martinerie, L.; Pertijs, J.C.L.M.; Allegaert, K.; Devriendt, K.; Masereeuw, R.; Monnens, L.A.; Lombes, M.

    2014-01-01

    CONTEXT: Sotos syndrome is a rare genetic disorder with a distinct phenotypic spectrum including overgrowth and learning difficulties. Here we describe a new case of Sotos syndrome with a 5q35 microdeletion, affecting the fibroblast growth factor receptor 4 (FGFR4) gene, presenting with infantile hy

  12. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

    Treppendahl, Marianne Bach; Qiu, Xiangning; Søgaard, Alexandra;

    2012-01-01

    Deletions of chromosome 5q are associated with poor outcomes in acute myeloid leukemia (AML) suggesting the presence of tumor suppressor(s) at the locus. However, definitive identification of putative tumor suppressor genes remains controversial. Here we show that a 106-nucleotide noncoding RNA...

  13. Beam experiments with state selected Ne (3P0, 3P2) metastable atoms

    Metastable rare gas atoms play an important role in all types of plasmas and gas discharges, e.g. in fluorescent lamps and in laser discharges (helium-neon laser or excimer lasers). In this thesis, the metastable states of NeI are studied. First, the theory of excited neon atoms and diatomic molecules is introduced, as well as Penning ionisation. Next, some experimental facilities are described (e.g. the dye laser system). With these instruments, natural lifetime measurements of the 2p fine structure states of NeI are carried out. Results are reported. Finally, total Penning ionisation cross sections are calculated using the optical potential model. (Auth.)

  14. 5-Pentadecyl-2-((p-tolyliminomethylphenol

    Amorn Petsom

    2013-07-01

    Full Text Available 5-Pentadecyl-2-((p-tolyliminomethylphenol has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-amino-1-methyl-aniline in 1,4-dioxane under reflux. The structure of the synthesized compound was assigned on the basis of elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectral data.

  15. Differential cross section for Ne(3P0) and Ne(3P2) scattered from ground state neon

    The differential elastic cross sections for electronically excited Ne(3P0) and Ne(3P2) from ground state neon atoms at thermal collision energies have been measured separately. Potentials for Ne(3P0)+Ne could be determined and the height of the intermediate potential maxima for Ne(3P2)+Ne could be estimated to 25 meV. By preparing Ne(3P2) in special Msub(J) states scattering in single Ω molecular states could be observed. (Auth.)

  16. Differential cross section for Ne(3P0) and Ne(3P2) scattered from ground state neon

    The differential elastic cross sections for electronically exited Ne(3P0) and Ne(3P2) from ground state neon atoms at thermal collision energies have been measured separately. Potentials for Ne(3P0)+Ne could be determined and the height of the intermediate potential maxima for Ne(3P2)+Ne could be estimated to 25 meV. By preparing Ne(3P2) in special Msub(J) states scattering in single Ω molecular states could be observed. (Author)

  17. NLO NRQCD disfavors the interpretation of X(3872) as χc1(2P)

    We study χc1(2P) inclusive hadroproduction at next-to-leading order (NLO) within the factorization formalism of nonrelativistic quantum chromodynamics (NRQCD), including both the color-singlet 3P1[1] and color-octet 3S1[8] c anti c Fock states. Assuming the recently discovered X(3872) hadron to be the 2P (1++) charmonium state, we perform a fit to the cross sections measured by the CDF, CMS, and LHCb Collaborations. We either obtain an unacceptably high value of χ2 or a value of vertical stroke R2P'(0) vertical stroke incompatible with well-established potential models. We thus conclude that NLO NRQCD is incompatible with the hypothesis X(3872)≡χc1(2P).

  18. Mobile P2P Fast Similarity Search

    Bocek, T; Hecht, F. V.; Hausheer, D; Hunt, E; Stiller, B.

    2009-01-01

    In informal data sharing environments, misspellings cause problems for data indexing and retrieval. This is even more pronounced in mobile environments, in which devices with limited input devices are used. In a mobile environment, similarity search algorithms for finding misspelled data need to account for limited CPU and bandwidth. This demo shows P2P fast similarity search (P2PFastSS) running on mobile phones and laptops that is tailored to uncertain data entry and use...

  19. Gene Expression Meta-Analysis identifies Cytokine Pathways and 5q Aberrations involved in Metastasis of ERBB2 Amplified and Basal Breast Cancer

    Thomassen, Mads; Tan, Qihua; Burton, Mark;

    2013-01-01

    show that high expression of 5q14 genes and low levels of TNFR2 pathway genes were associated with poor survival in basal-like cancers. Furthermore, low expression of 5q33 genes and interleukin-12 pathway genes were associated with poor outcome exclusively in ERBB2-like tumors. Conclusion: The......Background: Breast tumors have been described by molecular subtypes characterized by pervasively different gene expression profiles. The subtypes are associated with different clinical parameters and origin of precursor cells. However, the biological pathways and chromosomal aberrations that differ...... subgroups impact metastasis. Results: We have scrutinized publicly available gene expression datasets and identified molecular subtypes in 1,394 breast tumors with outcome data. By analysis of chromosomal regions and pathways using “Gene set enrichment analysis” followed by a meta-analysis, we identified...

  20. MINERVA: Collaborative P2P Search (Demo)

    Bender, Matthias; Michel, Sebastian; Triantafillou, Peter; Weikum, Gerhard; Zimmer, Christian; Böhm, Klemens; Jensen, Christian S.; Haas, Laura M.; Kersten, Martin L.; Larson, Per-Ake; Ooi, Beng Chin

    2005-01-01

    This paper proposes the live demonstration of a prototype of MINERVA, a novel P2P Web search engine. The search engine is layered on top of a DHT-based overlay network that connects an a-priori unlimited number of peers, each of which maintains a personal local database and a local search facility. Each peer posts a small amount of metadata to a physically distributed directory that is used to efficiently select promising peers from across the peer population that ca...

  1. Cooling of Neutron Stars and 3P_2 neutron gap

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``Nuclear medium cooling scenario'' is in favor of a suppressed value of the $3P_2$ neutron gap.

  2. 3p - 3d intershell interaction in Cr

    The photoemission of Cr films deposited under UHV conditions has been investigated in the photon energy range from 30 eV to 230 eV. The 3p - 3d intershell interaction gives rise to a strong maximum in the 3d partial yield above the 3p threshold. (orig.) 891 KBE/orig. 892 RDG

  3. A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk

    Clark Susan

    2009-06-01

    Full Text Available Abstract Background Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH. Although meiotic recombination maps are plentiful, little is known about mitotic recombination. The APC gene (chr5q21 is mutated in most colorectal tumours and its usual mode of LOH is mitotic recombination. Methods We mapped mitotic recombination boundaries ("breakpoints" between the centromere (~50 Mb and APC (~112 Mb in early colorectal tumours. Results Breakpoints were non-random, with the highest frequency between 65 Mb and 75 Mb, close to a low copy number repeat region (68–71 Mb. There were, surprisingly, few breakpoints close to APC, contrary to expectations were there constraints on tumorigenesis caused by uncovering recessive lethal alleles or if mitotic recombination were mechanistically favoured by a longer residual chromosome arm. The locations of mitotic and meiotic recombination breakpoints were correlated, suggesting that the two types of recombination are influenced by similar processes, whether mutational or selective in origin. Breakpoints were also associated with higher local G+C content. The recombination and gain/deletion breakpoint maps on 5q were not, however, associated, perhaps owing to selective constraints on APC dosage in early colorectal tumours. Since polymorphisms within the region of frequent mitotic recombination on 5q might influence the frequency of LOH, we tested the 68–71 Mb low copy number repeat and nearby tagSNPs, but no associations with colorectal cancer risk were found. Conclusion LOH on 5q is non-random, but local factors do not greatly influence the rate of LOH at APC or explain inter differential susceptibility to colorectal tumours.

  4. Assignment of human sprouty 4 gene to chromosome segment 5q32∼33 and analysis of its pattern of expression

    Hua Liu; Jin-Zhong Chen; Shao-Hua Gu; Jian-Liang Dai; En-Pang Zhao; Lu Huang; Wang-Xiang Xu; Yi Xie; Yu-Min Mao

    2003-04-01

    The human sprouty 4 (SPYR4) gene was localized to chromosome band 5q32∼33 by screening the Stanford radiation hybrid G3 panel using a SPRY4-specific primer pair for PCR. Northern blot analysis revealed two different mRNAs (5 kb and 2 kb) in liver, skeletal muscle, heart, lung, kidney, spleen, placenta and small intestine. Reverse transcriptase-PCR analysis showed that SPYR4 was expressed in all tested tissues to different levels.

  5. Electronic states of BP, BP +, BP -, B 2P 2, B2P2- and B2P2+

    Linguerri, Roberto; Komiha, Najia; Oswald, Rainer; Mitrushchenkov, Alexander; Rosmus, Pavel

    2008-05-01

    Using augmented sextuple zeta basis sets and internally contracted multireference configuration interaction (MRCI) wavefunctions, potential energy, electric dipole and transition moments have been computed for the X 3Π, a 1Σ +, b 1Π and A 3Σ - states of BP, X 2Σ + and A 2Π states of BP - and X 4Σ - and A 4Π states of BP +. From these data spectroscopic constants, radiative transition probabilities and photoelectron spectra of BP - and BP have been evaluated. The non-vanishing spin-orbit coupling elements between the four low lying triplet and singlet states of the neutral BP have also been calculated from MRCI wavefunctions. The treatment of the corresponding perturbations in the manifold of dense rovibrational states in the three lowest states would require a precise knowledge of the electronic excitation energies. Our best singlet-triplet separations (X-a) are calculated to be 2412 cm -1 (MRCI) and 2482 cm -1 (restricted coupled cluster with perturbative triples (RCCSD(T))) with an estimated error bound of about ±200 cm -1. All three states have long radiative lifetimes with cascading among the rovibrational levels of different states. The ionization energy IE e of BP is calculated to be 9.22 eV (MRCI) and 9.48 eV (RCCSD(T)), the electron affinity EA e 2.51 eV (MRCI) and 2.74 eV (RCCSD(T)). The photoelectron spectra of BP and BP - have been obtained from the Franck-Condon factors of the MRCI potentials. For the UV spectroscopy the dipole allowed radiative transition probabilities are given for A 3Σ - ↔ X 3Π, b 1Π ↔ a 1Σ + of BP, A 2Π ↔ X 2Σ + of BP - and A 4Π ↔ X 4Σ - of BP +. The ionization energy IE e of B 2P 2 of 8.71 eV and the electron affinity EA e of 2.34 eV have been calculated by the RCCSD(T)/aVQZ approach. Also the harmonic vibrational wavenumbers for the electronic ground states of the ions B2P2+ and B2P2- are given.

  6. WAVELENGTHS OF THE 3p-3d TRANSITIONS OF THE Co- AND Fe-LIKE IONS : THE EFFECTS OF ELECTRON CORRELATION

    Chen, M.

    1988-01-01

    The experimental observations of the 3p6 3d9 2D - 3p5 3dl0 2p transitions of the Co-like ions and 3p6 3d8 3F4 - 3p5 3d9 3F3 of the Fe-like ions have recently been extended to highly charged ions of heavy elements up to uranium (Z = 92). A comparison between the observed energies and calculated values from the Dirac-Fock model indicated persistent diicrepancies of 3-4 eV for al1 ions. Systematic multiconfiguration Dirac-Fock caiculations for these transitions have been carried out with emphasi...

  7. The human and mouse receptors of hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11

    Spicer, A.P.; McDonald, J.A. [Mayo Clinic Scottsdale, AZ (United States); Roller, M.L.; Camper, S.A. [Univ. of Michigan Medical School, Ann Arbor, MI (United States)] [and others

    1995-11-01

    The gene for the receptor for hyaluronan-mediated motility, RHAAM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific back-crosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q-syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias. 18 refs., 1 fig.

  8. Intercombination decay of 3s3p3P10 in Mg I-like Ni and Cu

    The intercombination transition 3s21S0-3s3p 3p10 in Ni16+ and Cu17+ has been studied by beam-foil spectroscopic methods. Decay curve analysis yields lifetime values of (12.0+-1.0) ns and (8.8+-0.6) ns for Ni and Cu in agreement with various predictions. (orig./WL)

  9. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

    Glubb, Dylan M; Maranian, Mel J; Michailidou, Kyriaki;

    2015-01-01

    Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals an...

  10. 75 FR 23574 - Airworthiness Directives; CFM International, S.A. CFM56-5B1/P, -5B2/P, -5B3/P, -5B3/P1, -5B4/P...

    2010-05-04

    ... INFORMATION: The FAA proposed to amend 14 CFR part 39 by superseding AD 2009-01-01, Amendment 39-15779 (73 FR... (74 FR 67834). That action proposed to require continuous monitoring of EGT margin deterioration... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3) Will not have a...

  11. Genomic characterization of uncommon human G3P[6] rotavirus strains causing diarrhea in children in Italy in 2009.

    Ianiro, Giovanni; Delogu, Roberto; Fiore, Lucia; Ruggeri, Franco M

    2015-07-01

    Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis in young children, causing up to 450,000 deaths worldwide, mostly in developing countries. Most of RVA human infections in developed countries are related to five major G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8]. During the surveillance activity of RotaNet-Italy, three uncommon G3P[6] RVA strains, designated as RVA/Human-wt/ITA/NA01/2009/G3P[6], RVA/Human-wt/ITA/NA06/2009/G3P[6], and RVA/Human-wt/ITA/NA19/2009/G3P[6], were identified in the stools of children with diarrhea hospitalized in Southern Italy in 2009. Samples NA01, NA06 and NA19 were characterized as genotype G3P[6]. To investigate the three strains further, partial sequencing of the eleven genomic segments was performed. RVA strains NA01, NA06 and NA19 were found to share the rare genotype constellation: G3-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2, which had not been reported previously in continental Italy. The phylogenetic analysis of the eleven genomic segments showed no evidence of zoonosis or inter-species reassortment at the origin of the Italian G3P[6] strains, indicating that they possessed DS-1-like genomic constellations similar to those detected previously in human cases in Africa and Europe. The analysis of the hypervariable regions of VP7 and VP4 (VP8*) revealed high amino acid identity between the Italian G3P[6] RVA strains involved in this study. PMID:25913157

  12. Resonant Auger decay of Ar 2p3/2-14s and 2p3/2-14p states excited by electron impact

    Auger spectra of resonantly excited 2p3/2-14s and 2p3/2-14p states in argon were measured by (e,2e) technique. The 99.2-eV scattered electrons were detected in coincidence with L3-M23M23 Auger electrons, and the experiment was performed at 343.6- and 344.9-eV electron impact to tune the energy loss to the energy of the dipole-allowed and the dipole-forbidden excitations, respectively. The resonant Auger spectra are obtained upon subtraction of the overlapping signal due to the outer-shell ionization, which was recorded at 340-eV electron-impact energy. The most intense groups of Auger transitions from 2p3/2-14s (J=1,2) and 2p3/2-14p (J=0,1,2,3) states are identified by comparison with the results of the two-step model, based on distorted-wave Born approximation with exchange and multiconfiguration descriptions of the relaxed states. The 4 s spectrum displays a substantially larger shake-up contribution than the one observed in photoexcitation experiments, which may be explained by the interference of the resonant decay path with the direct ionization excitation of the Ar 3p subshell. The majority of the observed 4p signal is assigned to the monopole and quadrupole excitations of the ground state.

  13. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae.

    Manabe, Kunio; Kawano-Kawada, Miyuki; Ikeda, Koichi; Sekito, Takayuki; Kakinuma, Yoshimi

    2016-06-01

    The vacuolar membrane proteins Ypq1p, Ypq2p, and Ypq3p of Saccharomyces cerevisiae are known as the members of the PQ-loop protein family. We found that the ATP-dependent uptake activities of arginine and histidine by the vacuolar membrane vesicles were decreased by ypq2Δ and ypq3Δ mutations, respectively. YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Δ and ypq3Δ. The vacuolar membrane vesicles isolated from the resulting quadruple deletion mutant ypq1Δypq2Δypq3Δavt1Δ completely lost the uptake activity of basic amino acids, and that of histidine, but not lysine and arginine, was evidently enhanced by overexpressing YPQ3 in the mutant. These results suggest that Ypq3p is specifically involved in the vacuolar uptake of histidine in S. cerevisiae. The cellular level of Ypq3p-HA(3) was enhanced by depletion of histidine from culture medium, suggesting that it is regulated by the substrate. PMID:26928127

  14. Chromosome 3p alterations in pancreatic endocrine neoplasia

    Amato, Eliana; Barbi, Stefano; Malpeli, Giorgio; Bersani, Samantha; Pelosi, Giuseppe; Capelli, Paola

    2010-01-01

    Pancreatic endocrine tumors (PET) are rare neoplasms classified as functioning (F-PET) or non-functioning (NF-PET) according to the presence of a clinical syndrome due to hormonal hypersecretion. PETs show variable degrees of clinical aggressiveness and loss of chromosome 3p has been suggested to be associated with an advanced stage of disease. We assessed chromosome 3p copy number in 113 primary PETs and 32 metastases by fluorescence in situ hybridization (FISH) using tissue microarrays. The series included 56 well-differentiated endocrine tumors (WDET), 62 well-differentiated endocrine carcinomas (WDEC), and 6 poorly differentiated endocrine carcinomas (PDEC). Chromosome 3p alterations were found in 23/113 (20%) primary tumors, with losses being predominant over gains (14% vs. 6%). Loss of 3p was found in 5/55 (9%) WDET, 11/52 (21%) WDEC, and never in PDEC. Gains of 3p were detected in 4/55 (7%) WDET, no WDEC, but notably in 3/6 (50%) PDEC (OR 23.6; P = 0.003). Metastases were more frequently monosomic for 3p compared to primary tumors (OR 3.6; P = 0.005). Monosomy was significantly associated with larger tumor size, more advanced tumor stage, and metastasis. No association was found with survival. Chromosome 3p copy number alterations are frequent events in advanced stage PET, with gains prevailing in PDEC while losses are more frequent in WDEC, supporting the view that a specific pattern of alterations are involved in these diverse disease subtypes. PMID:20981439

  15. She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p

    Böhl, Florian; Kruse, Claudia; Frank, Andrea; Ferring, Dunja; Jansen, Ralf-Peter

    2000-01-01

    RNA localization is a widespread mechanism to achieve localized protein synthesis. In budding yeast, localization of ASH1 mRNA controls daughter cell-specific accumulation of the transcriptional regulator Ash1p, which determines mating type switching. ASH1 mRNA localization depends on four independently acting sequences (‘zipcodes’) within the mRNA. In addition, the class V myosin Myo4p and a set of She proteins with as yet unknown function are essential for ASH1 localization. Here we show th...

  16. Size-tunable, hexagonal plate-like Cu3P and Janus-like Cu-Cu3P nanocrystals.

    De Trizio, Luca; Figuerola, Albert; Manna, Liberato; Genovese, Alessandro; George, Chandramohan; Brescia, Rosaria; Saghi, Zineb; Simonutti, Roberto; Van Huis, Marijn; Falqui, Andrea

    2012-01-24

    We describe two synthesis approaches to colloidal Cu(3)P nanocrystals using trioctylphosphine (TOP) as phosphorus precursor. One approach is based on the homogeneous nucleation of small Cu(3)P nanocrystals with hexagonal plate-like morphology and with sizes that can be tuned from 5 to 50 nm depending on the reaction time. In the other approach, metallic Cu nanocrystals are nucleated first and then they are progressively phosphorized to Cu(3)P. In this case, intermediate Janus-like dimeric nanoparticles can be isolated, which are made of two domains of different materials, Cu and Cu(3)P, sharing a flat epitaxial interface. The Janus-like nanoparticles can be transformed back to single-crystalline copper particles if they are annealed at high temperature under high vacuum conditions, which makes them an interesting source of phosphorus. The features of the Cu-Cu(3)P Janus-like nanoparticles are compared with those of the striped microstructure discovered more than two decades ago in the rapidly quenched Cu-Cu(3)P eutectic of the Cu-P alloy, suggesting that other alloy/eutectic systems that display similar behavior might give origin to nanostructures with flat, epitaxial interface between domains of two diverse materials. Finally, the electrochemical properties of the copper phosphide plates are studied, and they are found to be capable of undergoing lithiation/delithiation through a displacement reaction, while the Janus-like Cu-Cu(3)P particles do not display an electrochemical behavior that would make them suitable for applications in batteries. PMID:22136519

  17. Au Nanowire-Striped Cu3P Platelet Photoelectrocatalysts.

    Dutta, Anirban; Samantara, Aneeya K; Adhikari, Samrat Das; Jena, Bikash Kumar; Pradhan, Narayan

    2016-03-17

    A stripy pattern of continuous epitaxial growth of thin Au nanowires on plasmonic Cu3P platelets is reported. The obtained Au-Cu3P heterostructures retain their wide area interfacial heterojunction, which is typically not observed in metal-semiconductor heterostructures. This is performed by phosphine-mediated in situ reduction of Au ions on specific facets of Cu3P platelets. The intriguing stripy movements of nanowires are regulated by strong surface binding ligands. Because this is a dual plasmon heterostructure with wide visible absorption window, these are further explored as a photoelectrocatalyst for efficient hole transfer and sensing of an important biomolecule, nicotinamide adenine dinucleotide (NADH). The observed anodic photocurrent was 30 times higher in the presence of NADH, and this proves that the heterostructured material is an ideal photosenser and an efficient catalyst for solar energy conversion. PMID:26938025

  18. 5q14.3 deletion neurocutaneous syndrome: Contiguous gene syndrome caused by simultaneous deletion of RASA1 and MEF2C: A progressive disease.

    Ilari, Rita; Agosta, Guillermo; Bacino, Carlos

    2016-03-01

    We report the case of a young girl who was presented with complex clinical symptoms caused by the deletion of contiguous genes: RASA1 and MEF2C, located on chromosome 5q14.3. Specifically, the diagnosis of her skin disorder and vascular malformations involving central nervous system is consistent with a RASopathy. The child's neurological manifestations are observed in most patients suffering from 5q14.3 by deletion or mutation of the MEF2C gene. A review of the literature allowed us to conclude that the contiguous deletion of genes RASA1 and MEF2C fulfills the criteria for the diagnosis of a Neurocutaneous syndrome as proposed by Carr et al. [2011]. We also assessed the penetrance of RASA1 and clinical manifestations of MEF2C according to the type of deletion. This child described presents the complete symptomatology of both deleted genes. We would also like to highlight the progression of the disorder. PMID:26774077

  19. Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study

    Ke, Juntao; Lou, Jiao; Chen, Xueqin; Li, Jiaoyuan; Liu, Cheng; Gong, Yajie; Yang, Yang; Zhu, Ying; Zhang, Yi; Gong, Jing

    2015-01-01

    Large-scale genome-wide association studies (GWAS) have established chromosome 5q31.1 as a susceptibility locus for colorectal cancer (CRC), which was still lack of causal genetic variants. We searched potentially regulatory single nucleotide polymorphisms (SNPs) in the overlap region between linkage disequilibrium (LD) block of 5q31.1 and regulatory elements predicted by histone modifications, then tested their association with CRC via a case-control study. Among three candidate common variants, we found rs17716310 conferred significantly (heterozygous model: OR = 1.273, 95% confidence interval (95%CI) = 1.016–1.595, P = 0.036) and marginally (dominant model: OR = 1.238, 95%CI = 1.000–1.532, P = 0.050) increase risk for CRC in a Chinese population including 695 cases and 709 controls. This variation was suggested to be regulatory altering the activity of enhancer that control PITX1 expression. Using epigenetic information such as chromatin immunoprecipitation-sequencing (ChIP-seq) data might help researchers to interpret the results of GWAS and locate causal variants for diseases in post-GWAS era. PMID:26381143

  20. P3P semantic checker of site behaviours

    Grande, Robson Eduardo; Zorzo, Sérgio Donizetti

    2006-01-01

    The interactive use of the web between users and service providers introduces a privacy problem that involves the undesired disclosing of user personal information, mainly with the presence of personalization that needs this type of information. Also there are many manners to face it, but the Platform for Privacy Preferences (P3P) is one that provides a variable level of privacy for the user’s browsing. However, the P3P only introduces a privacy contract between the site and the user, without...

  1. P2P IPTV Measurement: A Comparison Study

    Silverston, Thomas; Fourmaux, Olivier

    2006-01-01

    With the success of P2P file sharing, new emerging P2P applications arise on the Internet for streaming content like voice (VoIP) or live video (IPTV). Nowadays, there are lots of works measuring P2P file sharing or P2P telephony systems, but there is still no comprehensive study about P2P IPTV, whereas it should be massively used in the future. During the last FIFA world cup, we measured network traffic generated by P2P IPTV applications like PPlive, PPstream, TVants and Sopcast. In this pap...

  2. Main: 1M2P [RPSD[Archive

    Full Text Available 1M2P トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...LVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA corn_1M2P.jpg ...

  3. Dsj meson decay in the C3P0 model

    Full text. Fock-Tani is a field theory formalism appropriated for the simultaneous treatment of composite particles and their constituents. The formalism was originally developed for the treatment of problems in atomic physics and it was extended later on to the treatment of problems on hadron physics. In the Fock-Tani formalism one starts with the Fock representation of the system using field operators of elementary constituents which satisfy canonical (anti) commutation relations. Composite-particle field operators are linear combinations of the elementary-particle operators and do not generally satisfy canonical (anti) commutation relations. 'Ideal' field operators acting on an enlarged Fock space are then introduced in close correspondence with the composite ones. Next, a given unitary transformation, which transforms the single composite states into single ideal states, is introduced. Application of the unitary operator on the microscopic Hamiltonian, or on other hermitian operators expressed in terms of the elementary constituent field operators, gives equivalent operators which contain the ideal field operators. The effective Hamiltonian in the new representation has a clear physical interpretation in terms of the processes it describes. Since all field operators in the new representation satisfy canonical (anti)commutation relations, the standard methods of quantum field theory can then be readily applied. For a long time the pair creation models for strong hadronic decays have been formulated. The 3P0 model is typical decay model which considers only OZI-allowed strong decays. The 3P0 model considers a quark-antiquark par creation in the presence of the initial state meson. The quark-antiquark par is created with the vacuum quantum numbers. This model can also be obtained from the non-relativistic limit of the pair creation Hamiltonian. Applying the Fock-Tani transformation to the pair creation Hamiltonian produces the characteristic expansion in powers of

  4. Structure of Tl2Mo2P2O11

    Dimolybdenum dithallium diphosphate, Tl2Mo2P2O11, is isotypic with K2Mo2P2O11. Its framework is built from the original Mo2P2O15 unit, formed by one Mo2O11 group sharing four of its corners with two PO4 tetrahedra, leading to [Mo2P2O13]∞ chains running along c. The [Mo2P2O11]∞ framework forms two different intersecting tunnels running along c and left angle 110 right angle , where the TI+ ions are located. (orig.)

  5. Myelodysplastic disorders carrying both isolated del(5q and JAK2V617F mutation: concise review, with focus on lenalidomide therapy

    Musto P

    2014-06-01

    Full Text Available Pellegrino Musto,1 Vittorio Simeon,2 Roberto Guariglia,3 Gabriella Bianchino,4 Vitina Grieco,4 Filomena Nozza,4 Francesco La Rocca,2 Gioacchino Marziano,1 Anna Vittoria Lalinga,5 Emiliano Fabiani,6 Maria Teresa Voso,6 Patrizia Scaravaglio,7 Cristina Mecucci,8 Giovanni D'Arena31Scientific Direction, 2Laboratory of Preclinical and Translational Research, 3Unit of Hematology and Stem Cell Transplantation, 4Laboratory of Clinical Research and Advanced Diagnostics, 5Pathology Unit, IRCCS, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy; 6Department of Hematology, Universita Cattolica del Sacro Cuore, Rome, Italy; 7Laboratory of Internal Medicine and Hematology, S Luigi Gonzaga Hospital, Orbassano, Italy; 8Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, ItalyAbstract: The concomitant presence of del(5q and JAK2V617F mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neoplasms. Lenalidomide may induce rapid, profound, and long-lasting responses in a subset of these patients. However, the mechanism(s by which the drug acts in these conditions remain not completely elucidated. A new case report and a review of all cases published so far in this setting are provided. Furthermore, the possibility of categorizing – from a clinical, pathological, and biological point of view – for at least some of these patients as a potential distinct entity is discussed.Keywords: myelodysplastic syndromes, myeloproliferative neoplasms, lenalidomide, del(5q, JAK2, World Health Organization

  6. Lenalidomide for the Treatment of Low- or Intermediate-1-Risk Myelodysplastic Syndromes Associated with Deletion 5q Cytogenetic Abnormality: An Evidence Review of the NICE Submission from Celgene.

    Blommestein, Hedwig M; Armstrong, Nigel; Ryder, Steve; Deshpande, Sohan; Worthy, Gill; Noake, Caro; Riemsma, Rob; Kleijnen, Jos; Severens, Johan L; Al, Maiwenn J

    2016-01-01

    The National Institute for Health and Care Excellence (NICE) invited the manufacturer of lenalidomide (Celgene) to submit evidence of the clinical and cost effectiveness of the drug for treating adults with myelodysplastic syndromes (MDS) associated with deletion 5q cytogenetic abnormality, as part of the Institute's single technology appraisal (STA) process. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG). This paper describes the company's submission, the ERG review, and the NICE's subsequent decisions. The ERG reviewed the evidence for clinical and cost effectiveness of the technology, as submitted by the manufacturer to the NICE. The ERG searched for relevant additional evidence and validated the manufacturer's decision analytic model to examine the robustness of the cost-effectiveness results. Clinical effectiveness was obtained from a three-arm, European, randomized, phase III trial among red blood cell (RBC) transfusion-dependent patients with low-/intermediate-1-risk del5q31 MDS. The primary endpoint was RBC independence for ≥26 weeks, and was reached by a higher proportion of patients in the lenalidomide 10 and 5 mg groups compared with placebo (56.1 and 42.6 vs 5.9 %, respectively; both p submitted a Patient Access Scheme (PAS) that provided lenalidomide free of charge for patients who remained on treatment after 26 cycles. This PAS improved the ICER to £25,300, although the AC considered the proportion of patients who received treatment beyond 26 cycles, and hence the ICER, to be uncertain. Nevertheless, the AC accepted a commitment from the manufacturer to publish, once available, data on the proportion of patients eligible for the PAS, and believed this provided reassurance that lenalidomide was a cost-effective treatment for low- or intermediate-1-risk MDS patients. PMID:26314282

  7. Doubly excited 3P(e) resonant states in Ps(-)

    Ho, Y. K.; Bhatia, A. K.

    1992-01-01

    Doubly excited 3P(e) resonant states in Ps(-) are calculated using a method of complex-coordinate rotation. Resonance parameters (both resonance positions and widths) for doubly excited states associated with the n = 2, 3, 4, 5, and 6 thresholds of positronium atoms are evaluated using elaborate Hylleraas-type functions. In addition to ten Feshbach-type resonances lying below various Ps thresholds, three shape resonances were identified, one each lying above the n = 2, 4, and 6 Ps thresholds. It is further noted that the energy levels for the present 3P(e) states are nearly degenerate with respect to the previously calculated 1P(0) states. Such a symmetric character suggests that the highly and doubly excited Ps(-), similar to its counterpart in H(-), would exhibit rovibrational behaviors analogous to those of XYX triatomic molecules.

  8. Spatial and electronic structure of the Ni3P surface

    To understand the catalytic effect in the Ni-Ni3P for the growth of carbon nanostructures, the structural and electronic properties of Ni3P surface are calculated from first-principles calculations. The calculated surface energies for the (0 0 1)-Ni4P4-terminated surface, the (0 0 1)-Ni8-terminated surface, and the (1 1 0)-Ni8-terminated surface show that the (0 0 1)-Ni4P4-terminated surface is energetically more stable within the allowed range of the chemical potential of P. Through the analysis of the partial density of states of Ni and P atoms in surface and bulk states, respectively, it is further found that due to the bond contractions of the surface layer, the core-level shifts of P atoms in the (0 0 1)-Ni4P4-terminated surface make P atoms in the Ni3P particles act as a catalyst. Finally, the obtained results of the work function show that the (0 0 1)-Ni4P4-terminated surface has the largest work function when compared with the other two studied surfaces.

  9. Acidic phospholipid-independent interaction of Yas3p, an Opi1-family transcriptional repressor of Yarrowia lipolytica, with the endoplasmic reticulum.

    Kobayashi, Satoshi; Tezaki, Satoshi; Horiuchi, Hiroyuki; Fukuda, Ryouichi; Ohta, Akinori

    2015-12-01

    In the n-alkane-assimilating yeast Yarrowia lipolytica, the transcription of ALK1, encoding cytochrome P450, that catalyses n-alkane hydroxylation is activated by a complex composed of Yas1p and Yas2p via a promoter element, ARE1, in response to n-alkanes. An Opi1-family transcription factor, Yas3p, represses the transcription by binding to Yas2p in the nucleus when cultured in glucose-containing medium, but it is localized to the ER, presumably through interaction with acidic phospholipids, phosphatidic acid and/or phospho inositides, when cultured in n-alkane-containing medium. Here, to elucidate the mechanisms regulating the localization of Yas3p, point and deletion mutants of Yas3p were constructed and analysed. The substitution of Trp(360) and Cys(361) by Arg abrogated the localization of Yas3p to the ER and decreased ARE1-mediated transcriptional activation by n-alkane. A Yas3p truncation mutant consisting of residues 259-422 did not bind to acidic phospholipids, but it was localized to the ER in the presence of n-alkane, implying the acidic-phospholipid-independent recruitment of this mutant to the ER in response to n-alkane. The W360R and C361R substitutions in this truncation mutant abolished its localization to the ER. The results suggest that these residues are implicated in the acidic phospholipid-independent interaction of Yas3p to the ER. PMID:26284565

  10. Assembly of cytochrome c oxidase: the role of hSco1p and hSco2p

    Paret, Claudia

    2001-01-01

    COX deficiency in human presents a plethora of phenotypes which is not surprising given the complexity of the enzyme structure and the multiple factors and many steps required for its assembly. A functional COX requires three mitochondrially encoded subunits (Cox1p, Cox2p and Cox3p), at least 10 nuclearly encoded subunits, some of which are tissue specific, and a yet unknown number of assembly factors. Mutations in four of these factors, hSco1p, hSco2p, hCox10p and hSurf1p, have been associat...

  11. Modeling Load Balancing in Heterogeneous Unstructured P2P Systems

    Zhi J. Li

    2005-01-01

    Full Text Available Load balancing is a generally concerned problem in peer-to-peer (P2P systems. Many researches on load balancing in the structured P2P systems have been launched currently, such as Chord or other DHTs. Although the researches on load balancing in unstructured P2P systems are emerged nowadays, the simple mechanisms achieved can only perform effectively in uniform environment. In this study, the influence on load balancing of the heterogeneity existed universally in unstructured P2P systems are analyzed, the unstructured P2P systems and their load balancing and the heterogeneity are modeled. Based on the formal model, the load balancing is analyzed quantitatively under static and dynamic environment and the typical load balancing algorithms are also analyzed. Some important conclusions are drawn which can be used in new models of load balancing in unstructured P2P systems.

  12. Research and Development of P2P Worms

    Li You; Zhi-Guang Qin

    2011-01-01

    With the development and the application of many popular peer-to-peer (P2P) systems such as eMule and BitTorrent,worms probably employ the features of these P2P networks to put them at risk.Some features,such as the local routing table and the application routing mechanism,are helpful to quickly distribute the P2P worms into the networks.This paper aims to give a comprehensive survey of P2P worms.The definition and the classification of P2P worms are discussed firstly.Then,the research and development of P2P worms, including experimental analysis,propagation modeling,and defensive approaches,are addressed and analyzed in detail.

  13. JS3P: junior staff programme pilot project

    Pretrel, H.; Tregoures, N.; Bessiron, V.; Dehoyos, A.; Delvallee, I.; Brisson, N.; Debayle, C.; Dubreuil, M.; Nicaise, G.; Perignon, J.P.; Richard, J. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 13 - Saint-Paul-lez-Durance (France); Reinke, N.; Kaulard, J.; Burgener, M.; Keesmann, S.; Schramm, B.; Seubert, A.; Sternkopf, J.; Thuma, G.; Weber, S. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Koln (Germany); Smidts, O.; Maillet, E.; Bucalossi, A.; Van haesendonck, M.; Uyttenhove, W.; Mertens, J. [AVN, Bruxelles (Belgium)

    2006-07-01

    Concept: The objective of the project is to allow junior staff members from the European Technical Safety Organisations (TSOs), IRSN, GRS and AVN, to work together with the final goal of creating a junior staff network, based on technical, cultural and personal interests. These projects are to show junior staff members at a very early stage during their career the need for European collaborations. They are also a tool to explore new subjects of co-operation. It is an initiative that should strengthen the links between the organisations and contribute to establishing the future of nuclear safety in Europe. A JS3P (Junior Staff Programme Pilot Project) is a project done jointly by 'junior' staff members from the three TSOs, where experience of 'seniors' is also integrated when needed. Compared to other collaborative activities, it has certain specific features. The JS3P favours staff exchanges, and technical meetings of several days should be planned during a project in order to encourage people to work together. Technical objectives are shared and the work is done jointly (reports, articles). The team involved in the JS3P should be as small as possible to favour its efficiency. The JS3P is short and easy to realize. Its duration is fixed to a maximum of about 12 months with the option to be prolonged. Typical topics are bibliographic work, comparison issues, scientific surveys, benchmark exercises and prospective investigations on innovative ideas. They can be linked to existing joint projects and then form a smaller module integrated into the large project. Topics may concern prospective issues, tentatively investigating new topics that can be seen as exploratory co-operation projects. Subjects may also concern research issues that are not a priority but that deserve to be investigated as new attractive topics. The JS3P is defined and managed by junior staff members. It is approved by a management board committee and supervised by a technical

  14. JS3P: junior staff programme pilot project

    Concept: The objective of the project is to allow junior staff members from the European Technical Safety Organisations (TSOs), IRSN, GRS and AVN, to work together with the final goal of creating a junior staff network, based on technical, cultural and personal interests. These projects are to show junior staff members at a very early stage during their career the need for European collaborations. They are also a tool to explore new subjects of co-operation. It is an initiative that should strengthen the links between the organisations and contribute to establishing the future of nuclear safety in Europe. A JS3P (Junior Staff Programme Pilot Project) is a project done jointly by 'junior' staff members from the three TSOs, where experience of 'seniors' is also integrated when needed. Compared to other collaborative activities, it has certain specific features. The JS3P favours staff exchanges, and technical meetings of several days should be planned during a project in order to encourage people to work together. Technical objectives are shared and the work is done jointly (reports, articles). The team involved in the JS3P should be as small as possible to favour its efficiency. The JS3P is short and easy to realize. Its duration is fixed to a maximum of about 12 months with the option to be prolonged. Typical topics are bibliographic work, comparison issues, scientific surveys, benchmark exercises and prospective investigations on innovative ideas. They can be linked to existing joint projects and then form a smaller module integrated into the large project. Topics may concern prospective issues, tentatively investigating new topics that can be seen as exploratory co-operation projects. Subjects may also concern research issues that are not a priority but that deserve to be investigated as new attractive topics. The JS3P is defined and managed by junior staff members. It is approved by a management board committee and supervised by a technical steering committee

  15. Supporting Collaboration and Creativity Through Mobile P2P Computing

    Wierzbicki, Adam; Datta, Anwitaman; Żaczek, Łukasz; Rzadca, Krzysztof

    Among many potential applications of mobile P2P systems, collaboration applications are among the most prominent. Examples of applications such as Groove (although not intended for mobile networks), collaboration tools for disaster recovery (the WORKPAD project), and Skype's collaboration extensions, all demonstrate the potential of P2P collaborative applications. Yet, the development of such applications for mobile P2P systems is still difficult because of the lack of middleware.

  16. Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia.

    Sen, Sanjukta; Agarwal, Rupesh; Ambulkar, Prafulla; Hinduja, Indira; Zaveri, Kusum; Gokral, Jyotsna; Pal, Asoke; Modi, Deepak

    2016-02-01

    The AZFc locus on the human Y chromosome harbours several multicopy genes, some of which are required for spermatogenesis. It is believed that deletion of one or more copies of these genes is a cause of infertility in some men. GOLGA2LY is one of the genes in the AZFc locus and it exists in two copies, GOLGA2P2Y and GOLGA2P3Y. The involvement of GOLGA2LY gene copy deletions in male infertility, however, is unknown. This study aimed to investigate the association of deletions of GOLGA2P2Y and GOLGA2P3Y gene copies with male infertility and with sperm concentration and motility. The frequency of GOLGA2P3Y deletion was significantly higher in oligozoospermic men compared with normozoospermic men (7.7% versus 1.2%; P = 0.0001), whereas the frequency of GOLGA2P2Y deletion was comparable between oligozoospermic and normozoospermic men (10.3% versus 11.3%). The deletion of GOLGA2P3Y but not GOLGA2P2Y was significantly higher (P = 0.03) in men with gr/gr rearrangements, indicating that GOLGA2P3Y deletions increase the susceptibility of men with gr/gr rearrangements to oligozoospermia. Furthermore, men with GOLGA2P3Y deletion had reduced sperm concentration and motility compared with men without deletion or with deletion of GOLGA2P2Y. These findings indicate GOLGA2P3Y gene copy may be candidate AZFc gene for male infertility. PMID:26655651

  17. Transition probabilities for NII 2p4f-2p3d and 2s2p23d-2s2p23p obtained by a semiclassical method

    2007-01-01

    Based on NII spectra, some transition probabilities for 2p4f-2p3d and 2s2p23d-2s2p23p are obtained by a semiclassical method. The results are in good agreement with other measurements and the data reported by the National Institute of Standards and Technology. The transition probability for a line of 424.18nm is reported for the first time. Meanwhile, a feasible method of calculating transition parameters related to special excited configurations or highly excited states is provided.

  18. Characterization of P2P IPTV Traffic: Scaling Analysis

    Silverston, Thomas; Fourmaux, Olivier; Salamatian, Kave

    2007-01-01

    P2P IPTV applications arise on the Internet and will be massively used in the future. It is expected that P2P IPTV will contribute to increase the overall Internet traffic. In this context, it is important to measure the impact of P2P IPTV on the networks and to characterize this traffic. Dur- ing the 2006 FIFA World Cup, we performed an extensive measurement campaign. We measured network traffic generated by broadcasting soc- cer games by the most popular P2P IPTV applications, namely PPLive...

  19. Search by shortcuts in P2P scientific collaboration system

    2005-01-01

    A P2P scientific collaboration is a P2P network whose members can share documents, co-compile papers and codes, and communicate with each other instantly. From the simulation experiment we found that P2P collaboration system is a power-law network with a tail between -2 and -3.We utilized the algorithm that searches by high-degree shortcuts to improve the scalability of p2p collaboration system. The experimental result shows that the algorithm works better than random walk algorithm.

  20. Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

    Glubb, Dylan M.; Maranian, Mel J.; Michailidou, Kyriaki; Pooley, Karen A.; Meyer, Kerstin B.; Kar, Siddhartha; Carlebur, Saskia; O’Reilly, Martin; Betts, Joshua A.; Hillman, Kristine M.; Kaufmann, Susanne; Beesley, Jonathan; Canisius, Sander; Hopper, John L.; Southey, Melissa C.; Tsimiklis, Helen; Apicella, Carmel; Schmidt, Marjanka K.; Broeks, Annegien; Hogervorst, Frans B.; van der Schoot, C. Ellen; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Ruebner, Matthias; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Pharoah, Paul D.P.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Yang, Rongxi; Surowy, Harald; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; González-Neira, Anna; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Anton-Culver, Hoda; Neuhausen, Susan L.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Schmutzler, Rita K.; Brauch, Hiltrud; Ko, Yon-Dschun; Brüning, Thomas; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tanaka, Hideo; Dörk, Thilo; Bogdanova, Natalia V.; Helbig, Sonja; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Lambrechts, Diether; Zhao, Hui; Weltens, Caroline; van Limbergen, Erik; Chang-Claude, Jenny; Flesch-Janys, Dieter; Rudolph, Anja; Seibold, Petra; Radice, Paolo; Peterlongo, Paolo; Barile, Monica; Capra, Fabio; Couch, Fergus J.; Olson, Janet E.; Hallberg, Emily; Vachon, Celine; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; See, Mee-Hoong; Cornes, Belinda; Cheng, Ching-Yu; Ikram, M. Kamran; Kristensen, Vessela; Zheng, Wei; Halverson, Sandra L.; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Van Asperen, Christi J.; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Klevebring, Daniel; Darabi, Hatef; Eriksson, Mikael; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W.M.; Collée, J. Margriet; Hall, Per; Li, Jingmei; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Cross, Simon S.; Reed, Malcolm W.R.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Shah, Mitul; Ghoussaini, Maya; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Tang, Anthony; Hamann, Ute; Torres, Diana; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Olswold, Curtis; Slager, Susan; Toland, Amanda E.; Yannoukakos, Drakoulis; Shen, Chen-Yang; Wu, Pei-Ei; Yu, Jyh-Cherng; Hou, Ming-Feng; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Healey, Catherine S.; Brown, Melissa A.; Ponder, Bruce A.J.; Chenevix-Trench, Georgia; Thompson, Deborah J.; Edwards, Stacey L.; Easton, Douglas F.; Dunning, Alison M.; French, Juliet D.

    2015-01-01

    Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals and control individuals from 52 studies in the Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent risk signals: the strongest associations were with 15 correlated variants (iCHAV1), where the minor allele of the best candidate, rs62355902, associated with significantly increased risks of both estrogen-receptor-positive (ER+: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.21–1.27, ptrend = 5.7 × 10−44) and estrogen-receptor-negative (ER−: OR = 1.10, 95% CI = 1.05–1.15, ptrend = 3.0 × 10−4) tumors. After adjustment for rs62355902, we found evidence of association of a further 173 variants (iCHAV2) containing three subsets with a range of effects (the strongest was rs113317823 [pcond = 1.61 × 10−5]) and five variants composing iCHAV3 (lead rs11949391; ER+: OR = 0.90, 95% CI = 0.87–0.93, pcond = 1.4 × 10−4). Twenty-six percent of the prioritized candidate variants coincided with four putative regulatory elements that interact with the MAP3K1 promoter through chromatin looping and affect MAP3K1 promoter activity. Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased MAP3K1 transcriptional activity. Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival. PMID:25529635

  1. Products of the Benzene + O(3P) Reaction

    Taatjes, Craig A.; Osborn, David L.; Selby, Talitha M.; Meloni, Giovanni; Trevitt, Adam J.; Epifanovsky, Evgeny; Krylov, Anna I.; Sirjean, Baptiste; Dames, Enoch; Wang, Hai

    2009-12-21

    The gas-phase reaction of benzene with O(3P) is of considerable interest for modeling of aromatic oxidation, and also because there exist fundamental questions concerning the prominence of intersystem crossing in the reaction. While its overall rate constant has been studied extensively, there are still significant uncertainties in the product distribution. The reaction proceeds mainly through the addition of the O atom to benzene, forming an initial triplet diradical adduct, which can either dissociate to form the phenoxy radical and H atom, or undergo intersystem crossing onto a singlet surface, followed by a multiplicity of internal isomerizations, leading to several possible reaction products. In this work, we examined the product branching ratios of the reaction between benzene and O(3P) over the temperature range of 300 to 1000 K and pressure range of 1 to 10 Torr. The reactions were initiated by pulsed-laser photolysis of NO2 in the presence of benzene and helium buffer in a slow-flow reactor, and reaction products were identified by using the multiplexed chemical kinetics photoionization mass spectrometer operating at the Advanced Light Source (ALS) of Lawrence Berkeley National Laboratory. Phenol and phenoxy radical were detected and quantified. Cyclopentadiene and cyclopentadienyl radical were directly identified for the first time. Finally, ab initio calculations and master equation/RRKM modeling were used to reproduce the experimental branching ratios, yielding pressure-dependent rate expressions for the reaction channels, including phenoxy + H, phenol, cyclopentadiene + CO, which are proposed for kinetic modeling of benzene oxidation.

  2. Photoinduced Kondo effect in CeZn3P3

    Kitagawa, J.; Kitajima, D.; Shimokawa, K.; Takaki, H.

    2016-01-01

    The Kondo effect, which originates from the screening of a localized magnetic moment by a spin-spin interaction, is widely observed in nonartificial magnetic materials, artificial quantum dots, and carbon nanotubes. In devices based on quantum dots or carbon nanotubes that target quantum information applications, the Kondo effect can be tuned by a gate voltage, a magnetic field, or light. However, the manipulation of the Kondo effect in nonartificial materials has not been thoroughly studied; in particular, the artificial creation of the Kondo effect remains unexplored. Per this subject study, however, a route for the optical creation of the Kondo effect in the nonartificial material p -type semiconductor CeZn3P3 is presented. The Kondo effect emerges under visible-light illumination of the material by a continuous-wave laser diode and is ultimately revealed by photoinduced electrical resistivity, which clearly exhibits a logarithmic temperature dependency. By contrast, a La-based compound (LaZn3P3 ) displays only normal metallic behavior under similar illumination. The photoinduced Kondo effect, which occurs at higher temperatures when compared with the Kondo effect in artificial systems, provides a potential range of operation for not only quantum information/computation devices but also for operation of magneto-optic devices, thereby expanding the range of device applications based on the Kondo effect.

  3. ZrCu2P2 and HfCu2P2 phosphides and their crystal structure

    Isostructural ZrCu2P2 and HfCu2P2 compounds are prepared for the first time. X-ray diffraction analysis (of powder, DRON-2.0 diffractometer, FeKsub(α) radiation) was used to study crystal structure of HfCu2P2 phosphide belonging to the CaAl2Si2 structural type (sp. group P anti 3 m 1, R=0.095). Lattice parameters the compounds are as follows: for ZrCu2P2 a=0.3810(1), c=0.6184(5); for HfCu2P2 a=0.3799(1), c=0.6160(2) (nm). Atomic parameters in the HfCu2P2 structure and interatomic distances are determined

  4. Research of P2P SIP technology%P2P SIP技术的研究

    隋晋光; 鲁士文

    2007-01-01

    在阐述P2P和SIP技术的基础上,引出了一种二者融合的新技术--P2P SIP,提出了采用P2P SIP技术系统的体系结构、工作方式,并且对P2P SIP技术的安全性问题进行了分析.

  5. Isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions

    Zubova, N A; Tupitsyn, I I; Shabaev, V M; Kozhedub, Y S; Plunien, G; Brandau, C; Stohlker, Th

    2016-01-01

    Isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z=8-92. The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions is significantly improved.

  6. Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions

    Zubova, N. A.; Malyshev, A. V.; Tupitsyn, I. I.; Shabaev, V. M.; Kozhedub, Y. S.; Plunien, G.; Brandau, C.; Stöhlker, Th.

    2016-05-01

    Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z =8 -92 . The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large-scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions is significantly improved.

  7. AlvisP2P: Scalable Peer-to-Peer Text Retrieval in a Structured P2P Network

    Luu, Toan; Skobeltsyn, Gleb; Klemm, Fabius; Puh, Maroje; Podnar Zarko, Ivana; Rajman, Martin; Aberer, Karl

    2008-01-01

    In this paper we present the AlvisP2P IR engine, which enables efficient retrieval with multi-keyword queries from a global document collection available in a P2P network. In such a network, each peer publishes its local index and invests a part of its local computing resources (storage, CPU, bandwidth) to maintain a fraction of a global P2P index. This investment is rewarded by the network-wide accessibility of the local documents via the global search facility. The AlvisP2P engine uses an o...

  8. First Detection of [C I] $^3$P$_1$-$^3$P$_0$ Emission from a Protoplanetary Disk

    Tsukagoshi, Takashi; Saito, Masao; Kitamura, Yoshimi; Shimajiri, Yoshito; Kawabe, Ryohei

    2015-01-01

    We performed single point [C I] $^3$P$_1$-$^3$P$_0$ and CO J=4-3 observations toward three T Tauri stars, DM Tau, LkCa 15, and TW Hya, using the Atacama Large Millimeter/submillimeter Array (ALMA) Band 8 qualification model receiver installed on the Atacama Submillimeter Telescope Experiment (ASTE). Two protostars in the Taurus L1551 region, L1551 IRS 5 and HL Tau, were also observed. We successfully detected [C I] emission from the protoplanetary disk around DM Tau as well as the protostellar targets. The spectral profile of the [C I] emission from the protoplanetary disk is marginally single-peaked, suggesting that atomic carbon (C) extends toward the outermost disk. The detected [C I] emission is optically thin and the column densities of C are estimated to be <~10$^{16}$ cm$^{-2}$ and ~10$^{17}$ cm$^{-2}$ for the T Tauri star targets and the protostars, respectively. We found a clear difference in the total mass ratio of C to dust, $M$(C)/$M$(dust), between the T Tauri stars and protostellar targets; t...

  9. Autoionization study of the Argon 2p satellites excited near the argon 2s threshold

    Wang, H.; Glans, P.; Hemmers, O. [Univ. of Nevada, Las Vegas, NV (United States)] [and others

    1997-04-01

    The dynamics of near-threshold photoionization is a complex phenomenon in which the many-electron character of the wavefunctions plays an important role. According to generalized time-independent resonant scattering theory, the transition matrix element from an initial state to a final state is the summation of the amplitudes of direct photoionization and an indirect term in which intermediate states are involved and the resonant behavior is embedded. Studies of the interference effects of intermediate states have been explored in the cases where the direct term is negligible. In the present work, electron time-of-flight spectra of the Ar 2p satellites were measured at two angles (magic and 0{degrees}) in the dipole plane with the exciting photon energy tuned in the vicinity of the Ar 2s threshold. For excitation far below or above the 2s threshold, the 2p satellites spectrum is dominated by 3p to np shakeup contributions upon the ionization of a 2p electron.

  10. Queries mining for efficient routing in P2P communities

    Ismail, Anis; Durand, Nicolas; Nachouki, Gilles; Hajjar, Mohammad

    2011-01-01

    Peer-to-peer (P2P) computing is currently attracting enormous attention. In P2P systems a very large number of autonomous computing nodes (the peers) pool together their resources and rely on each other for data and services. Peer-to-peer (P2P) Data-sharing systems now generate a significant portion of Internet traffic. Examples include P2P systems for network storage, web caching, searching and indexing of relevant documents and distributed network-threat analysis. Requirements for widely distributed information systems supporting virtual organizations have given rise to a new category of P2P systems called schema-based. In such systems each peer exposes its own schema and the main objective is the efficient search across the P2P network by processing each incoming query without overly consuming bandwidth. The usability of these systems depends on effective techniques to find and retrieve data; however, efficient and effective routing of content-based queries is a challenging problem in P2P networks. This wo...

  11. Measurement and Analysis of P2P IPTV Program Resource

    Wenxian Wang; Xingshu Chen; Haizhou Wang; Qi Zhang; Cheng Wang

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program na...

  12. Comparing Pedophile Activity in Different P2P Systems

    Raphaël Fournier; Thibault Cholez; Matthieu Latapy; Isabelle Chrisment; Clémence Magnien; Olivier Festor; Ivan Daniloff

    2014-01-01

    International audience Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use, previous academic works on this topic focused on one system at a time and their results are not directly comparable. We design a methodology for comparing KAD and eDonkey, two P2P systems among the most prominent ones an...

  13. Code wars 10 years of P2P software litigation

    Giblin, Rebecca

    2011-01-01

    Code Wars recounts the legal and technological history of the first decade of the P2P file sharing era, focusing on the innovative and anarchic ways in which P2P technologies evolved in response to decisions reached by courts with regard to their predecessors. With reference to US, UK, Canadian and Australian secondary liability regimes, this insightful book develops a compelling new theory to explain why a decade of ostensibly successful litigation failed to reduce the number, variety or availability of P2P file sharing applications - and highlights ways the law might need to change if it is

  14. SW-R2P: A Trusted Small World Overlay P2P Network with Zero Knowledge Identification

    Yingjie Xia

    2008-10-01

    Full Text Available In order to implement both the efficiency and security in the Peer-to-Peer (P2P network, we design a trusted small world overlay P2P network with the role based and reputation based access control policies, denoted as SW-R2P. The SW-R2P system integrates the small world topology with zero knowledge identification and Bayesian trust model. The zero knowledge identification is utilized to securely cluster all the peers into several groups without transferring any related information. The peer groups are then linked together to construct a trusted small world network based on the probabilities calculated by the Bayesian trust model. The simulation experiments demonstrate that the SW-R2P system achieves the performance with increased success rate in the resources lookup, strengthened robustness under the overwhelming traffic loadings, reduced reputation errors caused by the malicious peers and enhanced peer satisfaction rate for different trust metrics. In conclusion, the SW-R2P system collectively exploits the advantages of small world, zero knowledge identification and Bayesian trust model, therefore implementing a scalable, secure and efficient P2P network.

  15. P2P Concept Search: Some Preliminary Results

    Giunchiglia, Fausto; Kharkevich, Uladzimir; Noori, S.R.H

    2009-01-01

    Concept Search extends syntactic search, i.e., search based on the computation of string similarity between words, with semantic search, i.e., search based on the computation of semantic relations between complex concepts. It allows us to deal with ambiguity of natural language. P2P Concept Search extends Concept Search by allowing distributed semantic search over structured P2P network. The key idea is to exploit distributed, rather than centralized, background knowledge and indices.

  16. Chimpanzee chromosome 13 is homologous to human chromosome 2p

    Sun, N. C.; Sun, C. R.Y.; Ho, T.

    1977-01-01

    Similarities between human and chimpanzee chromosomes are shown by chromosome banding techniques and somatic cell hybridization techniques. Cell hybrids were obtained from the chimpanzee lymphocyte LE-7, and the Chinese hamster mutant cell, Gal-2. Experiments showed that the ACPL, MDHs, and Gal-Act genes could be assigned to chimpanzee chromosome 13, and since these genes have been assigned to human chromosme 2p, it is suggested that chimpanzee chromosome 13 is homologous to human chromosome 2p. (HLW)

  17. Mobile P2P Web Services Using SIP

    Guido Gehlen; Fahad Aijaz; Yi Zhu; Bernhard Walke

    2007-01-01

    Telecommunication networks and the Internet are growing together. Peer-to-Peer (P2P) services which are originally offered by network providers, like telephony and messaging, are provided through VoIP and Instant Messaging (IM) by Internet service providers, too. The IP Multimedia Subsystem (IMS) is the answer of the telecommunication industry to this trend and aims at providing Internet P2P and multimedia services controlled by the network operators. The IMS provides mobility and session man...

  18. Survey on Scheduling Technologies of P2P Media Streaming

    Guangxue Yue; Nanqing Wei; Jiansheng Liu; Xiaofeng Xiong; Linquan Xie

    2011-01-01

    P2P streaming media applications grows rapidly. Scheduling technologies are the key of streaming research. After review the history of distribution systems. We studied the main data distribution topology and P2P streaming scheduling technologies. Compared current scheduling algorithms. Finally made a conclusion and forecasted scheduling in the mesh-tree distribution structure, heterogeous network, alone with security in scheduling will be the hotspots in the near future.

  19. Characterization of P2P IPTV Traffic: Scaling Analysis

    Silverston, Thomas; Salamatian, Kave

    2007-01-01

    P2P IPTV applications arise on the Internet and will be massively used in the future. It is expected that P2P IPTV will contribute to increase the overall Internet traffic. In this context, it is important to measure the impact of P2P IPTV on the networks and to characterize this traffic. During the 2006 FIFA World Cup, we performed an extensive measurement campaign. We measured network traffic generated by broadcasting soccer games by the most popular P2P IPTV applications, namely PPLive, PPStream, SOPCast and TVAnts. From the collected data, we characterized the P2P IPTV traffic structure at different time scales. To the best of our knowledge, this is the first work, which presents a complete multiscale analysis of the P2P IPTV traffic. Our observations show that the network traffic has not the same scale behavior whether the applications use TCP or UDP. For all the applications, the download traffic is different from the upload traffic and the signaling traffic has an impact on the download traffic.

  20. Improving P2P live-content delivery using SVC

    Schierl, T.; Sánchez, Y.; Hellge, C.; Wiegand, T.

    2010-07-01

    P2P content delivery techniques for video transmission have become of high interest in the last years. With the involvement of client into the delivery process, P2P approaches can significantly reduce the load and cost on servers, especially for popular services. However, previous studies have already pointed out the unreliability of P2P-based live streaming approaches due to peer churn, where peers may ungracefully leave the P2P infrastructure, typically an overlay networks. Peers ungracefully leaving the system cause connection losses in the overlay, which require repair operations. During such repair operations, which typically take a few roundtrip times, no data is received from the lost connection. While taking low delay for fast-channel tune-in into account as a key feature for broadcast-like streaming applications, the P2P live streaming approach can only rely on a certain media pre-buffer during such repair operations. In this paper, multi-tree based Application Layer Multicast as a P2P overlay technique for live streaming is considered. The use of Flow Forwarding (FF), a.k.a. Retransmission, or Forward Error Correction (FEC) in combination with Scalable video Coding (SVC) for concealment during overlay repair operations is shown. Furthermore the benefits of using SVC over the use of AVC single layer transmission are presented.

  1. Network Awareness in P2P-TV Applications

    Traverso, Stefano; Leonardi, Emilio; Mellia, Marco; Meo, Michela

    The increasing popularity of applications for video-streaming based on P2P paradigm (P2P-TV) is raising the interest of both broadcasters and network operators. The former see a promising technology to reduce the cost of streaming content over the Internet, while offering a world-wide service. The latter instead fear that the traffic offered by these applications can grow without control, affecting other services, and possibly causing network congestion and collapse. The “Network-Aware P2P-TV Application over Wise Networks” FP7 project aims at studying and developing a novel P2P-TV application offering the chance to broadcast high definition video to broadcasters and to carefully manage the traffic offered by peers to the network, therefore avoiding worries to Internet providers about network overload. In such context, we design a simulator to evaluate performance of different P2P-TV solutions, to compare them both considering end-users’ and network providers’ perspectives, such as quality of service perceived by subscribers and link utilization. In this paper, we provide some results that show how effective can be a network aware P2P-TV system.

  2. P2P Data Management in Mobile Wireless Sensor Network

    Nida Sahar Sayeda

    2013-04-01

    Full Text Available The rapid growth in wireless technologies has made wireless communication an important source for transporting data across different domains. In the same way, there are possibilities of many potential applications that can be deployed using WSNs (Wireless Sensor Networks. However, very limited applications are deployed in real life due to the uncertainty and dynamics of the environment and scare resources. This makes data management in WSN a challenging area to find an approach that suits its characteristics. Currently, the trend is to find efficient data management schemes using evolving technologies, i.e. P2P (Peer-to-Peer systems. Many P2P approaches have been applied in WSNs to carry out the data management due to similarities between WSN and P2P. With the similarities, there are differences too that makes P2P protocols inefficient in WSNs. Furthermore, to increase the efficiency and to exploit the delay tolerant nature of WSNs, where ever possible, the mobile WSNs are gaining importance. Thus, creating a three dimensional problem space to consider, i.e. mobility, WSNs and P2P. In this paper, an efficient algorithm is proposed for data management using P2P techniques for mobile WSNs. The real world implementation and deployment of proposed algorithm is also presented

  3. Theatrical distribution and P2P movie piracy: a survey of P2P networks in Hungary using transactional data

    Bodó, B.; Lakatos, Z.

    2012-01-01

    This article examines what appears to be the most important factor shaping file sharing: the failure of traditional cultural markets to efficiently supply the demand in the online environment. Its findings are based on tracking the traffic of movies on three Hungarian P2P networks. This dataset is then matched with cinematic distribution data of the films tracked in P2P transactions. Central to our analysis is the assessment of two piracy paradigms: substitution and shortage, that is, whether...

  4. Additional investigations of silicon phosphides (SiP and Si3P2) at phosphor-diffused silicon wafers

    Results were obtained by X-ray microanalysis and neutron activation analysis. The formation of the Si3P2-phase (circular particles of about 15 μm in diameter) takes place on polished silicon slices during the phosphorus diffusion both in N2-O2-POCl3 carrier gas and in O2-P2O5 carrier gas. In this case the average phosphorus concentration in phosphorus glass sheet (reaction phase, i.e. SiO2-P2O5-phase) is greater than the limit value being placed in the interval c1 = (8,30 ... 9,44) mass-percent phosphorus for a temperature T = 1523 K (12500C). The surface concentration of phosphorus in silicon between the Si3P2-particles being formed on slices does not depend on the phosphorus concentration in the carrier gas. This constant concentration value is identical with the solid solubility limit for phosphorus in silicon, measured for C/sub F/ = 1.29 x 1021 P-atoms/cm3, resp. c/sub F/ = 2.72 mass percent. On the other hand the phosphorus concentration is C/sub G/ = 9.2 x 1020 P-atoms/cm3 in the interior of the diffused layer in silicon directly beside the Si3P2-particle. The formation of the SiP-phase was observed on lapped silicon slices for phosphorus diffusion in wet N2-O2-POCl3 carrier gas at a temperature T = 1523 K (12500C). (author)

  5. High-resolution absolute photoabsorption cross sections for Ne in the 1s2s and 1s2p resonant double excitation

    Kato, Masahiro [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Morishita, Yuichiro [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Koike, Fumihiro [School of Medicine, Kitasato University, Kitasato, Sagamihara 228-8555 (Japan); Fritzsche, Stephan [Physics Department, Kassel University, Heinrich-Plett-strasse 40, D-34132 Kassel (Germany); Yamaoka, Hitoshi [RIKEN, Harima Institute, Sayo, Hyogo 679-5148 (Japan); Tamenori, Yusuke [Japan Synchrotron Radiation Research Institute, Sayo, Hyogo 679-5198, Japan (Japan); Okada, Kazumasa [Department of Chemistry, Hiroshima University, Higashi-Hiroshima 739-8526 (Japan); Matsudo, Takahisa [Department of Chemistry, Hiroshima University, Higashi-Hiroshima 739-8526 (Japan); Gejo, Tatsuo [University of Hyogo, Kamigori, Hyogo 678-1297 (Japan); Suzuki, Isao H [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Saito, Norio [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan)

    2006-04-28

    The high-resolution absolute photoabsorption cross sections with an absolute photon energy scale for Ne 1s2p/1s2s double excitation in the energy region of 900-940 eV have been measured using a multi-electrode ionization chamber and monochromatized synchrotron radiation. The Ne [1s2p]({sup 3,1}P)nln'l' doubly excited states observed in the energy range of 900-920 eV are analysed with the aid of theoretical calculations based on the multiconfiguration Dirac-Fock method. The second strongest peak in this energy region is assigned to be [1s2p]({sup 3}P)3p4p.

  6. Four novel Loci (19q13, 6q24, 12q24, and 5q14 influence the microcirculation in vivo.

    M Kamran Ikram

    2010-10-01

    Full Text Available There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652. All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP spread across five loci were significantly associated (p<5.0×10(-8 with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p  =  1.61×10(-25, within the RASIP1 locus, rs225717 (6q24; p = 1.25×10(-16, adjacent to the VTA1 and NMBR loci, rs10774625 (12q24; p  =  2.15×10(-13, in the region of ATXN2,SH2B3 and PTPN11 loci, and rs17421627 (5q14; p = 7.32×10(-16, adjacent to the MEF2C locus. In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular

  7. P2P Simulator for Queries Routing Using Data Mining

    Anis ISMAIL

    2011-09-01

    Full Text Available Data mining is used to extract hidden information from large databases. In Peer-to-Peer context, achallenging problem is how to find the appropriate Peer to deal with a given query without overlyconsuming bandwidth. Different methods proposed routing strategies of queries taking into account theP2P network at hand. An unstructured P2P system based on an organization of Peers around Super-Peersthat are connected to Super-Super-Peer according to their semantic domains is considered. This paperintegrates Decision Trees in P2P architectures for predicting Query-Suitable Super-Peers representing acommunity of Peers, where one among them is able to answer the given query. In fact, by analyzing thequeries’ log file, a predictive model that avoids flooding queries in the P2P networks constructed bypredicting the appropriate Super-Peer, and hence the Peer to answer the query. The proposed architectureis based on a Decision Tree (Base-Knowledge - BK. The efficiency of these architectures is discussedconsidering architecture without knowledge (Baseline using only the flooding queries method to answerqueries. The advantage of this knowledge based model is the robustness in Queries routing mechanism andscalability in P2P Network.

  8. A Framework For Concept Drifting P2P Traffic Identification

    Guanghui Yan

    2013-08-01

    Full Text Available Identification of network traffic using port-based or payload-based analysis is becoming increasing difficult with many Peer-to-Peer (P2P application using dynamic ports, masquerading techniques, and encryption to avoid detection. To overcome this problem, several machine learning technique were proposed to classify P2P traffics. But in the real P2P network environment, new communities of peers often attend and old communities of peers often leave. It requires the identification methods to be capable of coping with concept drift, and updating the model incrementally. In this paper, we present a concept-adapting algorithm CluMC which is based on streaming data mining techniques to identify P2P applications in Internet traffic. The CluMC use micro-cluster structures which contain potential micro-cluster structures and outlier micro-cluster structures to classify the P2P traffic and discover the concept drift with limited memory. Our performance study over a number of real data sets that we captured at a main gateway router demonstrates the effectiveness and efficiency of our method.

  9. Behavioural Correlation for Detecting P2P Bots

    Al-Hammadi, Yousof

    2010-01-01

    In the past few years, IRC bots, malicious programs which are remotely controlled by the attacker through IRC servers, have become a major threat to the Internet and users. These bots can be used in different malicious ways such as issuing distributed denial of services attacks to shutdown other networks and services, keystrokes logging, spamming, traffic sniffing cause serious disruption on networks and users. New bots use peer to peer (P2P) protocols start to appear as the upcoming threat to Internet security due to the fact that P2P bots do not have a centralized point to shutdown or traceback, thus making the detection of P2P bots is a real challenge. In response to these threats, we present an algorithm to detect an individual P2P bot running on a system by correlating its activities. Our evaluation shows that correlating different activities generated by P2P bots within a specified time period can detect these kind of bots.

  10. Compromising Tor Anonymity Exploiting P2P Information Leakage

    Manils, Pere; Blond, Stevens Le; Kaafar, Mohamed Ali; Castelluccia, Claude; Legout, Arnaud; Dabbous, Walid

    2010-01-01

    Privacy of users in P2P networks goes far beyond their current usage and is a fundamental requirement to the adoption of P2P protocols for legal usage. In a climate of cold war between these users and anti-piracy groups, more and more users are moving to anonymizing networks in an attempt to hide their identity. However, when not designed to protect users information, a P2P protocol would leak information that may compromise the identity of its users. In this paper, we first present three attacks targeting BitTorrent users on top of Tor that reveal their real IP addresses. In a second step, we analyze the Tor usage by BitTorrent users and compare it to its usage outside of Tor. Finally, we depict the risks induced by this de-anonymization and show that users' privacy violation goes beyond BitTorrent traffic and contaminates other protocols such as HTTP.

  11. Model of Controlling the Hubs in P2P Networks

    Yuhua Liu

    2009-06-01

    Full Text Available Research into the hubs in Peer-to-Peer (P2P networks, and present a new method to avoid generating the hubs in the networks by controlling the logical topology structure of P2P networks. We firstly introduce the controlling ideas about hierarchizing the hubs. Then, we disclose and interpret the controlling model, and give out the concrete method to carry it out. Finally, we validate our controlling model via simulations and the simulation results demonstrate that our work is effective to control the hubs in P2P networks. Thus, this model can improve the network competence to defend against coordinated attacks, promote the network robustness, and ensure the network would develop continually and healthily.

  12. N(2P) in the dayglow - Measurement and theory

    Torr, Marsha R.; Torr, Douglas G.; Richards, P. G.

    1993-01-01

    During the ATLAS-1 mission, the first dayglow altitude profiles were obtained of the N(2P) emission at 3466 A. These observations were made in the sunlit thermosphere using the Imaging Spectrometric Observatory. As all previous work on this emission has been done under auroral conditions, this study represents the first examination of the photochemical sources and sinks of N(2P) in the normal daytime thermospheric, with comparison with measurements. We find that the observations are explained by a model in which the major source is photodissociation of N2, and quenching by O is the principal low-altitude loss process, with radiative decay to N(2D) dominating above 200 km. As the dominant loss processes are likely to result in the production of N(2D), N(2P) could be a moderate source of N(2D) and may be a factor to be taken into consideration in modeling NO.

  13. P2P STREAMING MEDIA INDUSTRY IN CHINA

    Dai, Steffi (Wenjing)

    2009-01-01

    The peer-to-peer (P2P) streaming media industry opened up a new era for the cyber age, has had a significant effect on many people?s leisure time, and has changed the way many people use entertainment. Over the past few years, this industry has developed dramatically in China, and it is thriving. In terms of the current situation, the P2P streaming media industry holds typical Chinese features that both enrich the audience?s cultural life, and have some impact on other kinds of mass media. Th...

  14. Silane photoabsorption spectra near the Si 2p thresholds: the geometry of Si 2p excited SiH4

    张卫华; 许如清; 李家明

    2003-01-01

    Based on the multiple-scattering self-consistent-field method, we have studied the photoabsorption spectra near the Si 2p thresholds of silane. According to our calculations, the clear assignments of the inner-shell photoabsorption spectra are provided. In comparison with the high-resolution experimental spectra, the geometric structure of the Si 2p-excited SiH4** is recommended to be of a C2v symmetry. More specifically, the Si 2p-excited Si4** have two bond lengths of 2.50 a.u. and another two bond lengths of 2.77 a.u., and the corresponding two bond angles are 104.0° and 112.5° respectively.

  15. Measurement and analysis of P2P IPTV program resource.

    Wang, Wenxian; Chen, Xingshu; Wang, Haizhou; Zhang, Qi; Wang, Cheng

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs. PMID:24772008

  16. Comparing Pedophile Activity in Different P2P Systems

    Raphaël Fournier

    2014-07-01

    Full Text Available Peer-to-peer (P2P systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use, previous academic works on this topic focused on one system at a time and their results are not directly comparable. We design a methodology for comparing KAD and eDonkey, two P2P systems among the most prominent ones and with different anonymity levels. We monitor two eDonkey servers and the KAD network during several days and record hundreds of thousands of keyword-based queries. We detect pedophile-related queries with a previously validated tool and we propose, for the first time, a large-scale comparison of pedophile activity in two different P2P systems. We conclude that there are significantly fewer pedophile queries in KAD than in eDonkey (approximately 0.09% vs. 0.25%.

  17. P2P Domain Classification using Decision Tree

    Ismail, Anis

    2011-01-01

    In Peer-to-Peer context, a challenging problem is how to find the appropriate peer to deal with a given query without overly consuming bandwidth? Different methods proposed routing strategies of queries taking into account the P2P network at hand. This paper considers an unstructured P2P system based on an organization of peers around Super-Peers that are connected to Super-Super- Peer according to their semantic domains; By analyzing the queries log file, a predictive model that avoids flooding queries in the P2P network is constructed after predicting the appropriate Super-Peer, and hence the peer to answer the query. A challenging problem in a schema-based Peer-to-Peer (P2P) system is how to locate peers that are relevant to a given query. In this paper, architecture, based on (Super-)Peers is proposed, focusing on query routing. The approach to be implemented, groups together (Super-)Peers that have similar interests for an efficient query routing method. In such groups, called Super-Super-Peers (SSP), Su...

  18. {2p_\\pi}-{2p_\\sigma} crossing in heavy symmetric ion-atom collisions: I. Level structure

    Morovi´c, Tihomir; Sepp, Wolf-Dieter; Fricke, Burkhard

    1982-01-01

    Ab initio self-consistent DFS calculations are performed for five different symmetric atomic systems from Ar-Ar to Pb-Pb. The level structure for the {2p_\\pi}-{2p_\\sigma} crossing as function of the united atomic charge Z_u is studied and interpreted. Manybody effects, spin-orbit splitting, direct relativistic effects as well as indirect relativistic effects are differently important for different Z_u. For the I-I system a comparison with other calculations is given.

  19. Theatrical distribution and P2P movie piracy: a survey of P2P networks in Hungary using transactional data

    B. Bodó; Z. Lakatos

    2012-01-01

    This article examines what appears to be the most important factor shaping file sharing: the failure of traditional cultural markets to efficiently supply the demand in the online environment. Its findings are based on tracking the traffic of movies on three Hungarian P2P networks. This dataset is t

  20. Syntenic homology of human unique DNA sequences within chromossome regions 5q31, 10q22, 13q32-33 and 19q13.1 in the great apes

    Vallente-Samonte Rhea U.

    2000-01-01

    Full Text Available Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1 led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR, gorilla (Gorilla gorilla, GGO and orangutan (Pongo pygmaeus, PPY chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to the chromosome 5q31-specific DNA probe were observed at HSA 5q31, PTR 4q31, GGO 4q31 and PPY 4q31, while fluorescent signals using the chromosome 10q22-specific DNA probe were noted at HSA 10q22, PTR 8q22, GGO 8q22 and PPY 7q22. The chromosome arms showing hybridization signals to the Quint-EssentialTM 13-specific DNA probe were identified as HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 and PPY 14q32-33, while those presenting hybridization signals to the chromosome 19q13.1-specific DNA probe were identified as HSA 19q13.1, PTR 20q13, GGO 20q13 and PPY 20q13. All four probes presumably hybridized to homologous chromosomal locations in the apes, which suggests a homology of certain unique DNA sequences among hominoid species.

  1. Nascent 60S ribosomal subunits enter the free pool bound by Nmd3p.

    Ho, J. H.; Kallstrom, G; Johnson, A. W.

    2000-01-01

    Nmd3p from yeast is required for the export of the large (60S) ribosomal subunit from the nucleus (Ho et al., 2000). Here, we show that Nmd3p forms a stable complex with free 60S subunits. Using an epitope-tagged Nmd3p, we show that free 60S subunits can be coimmunoprecipitated with Nmd3p. The interaction was specific for 60S subunits; 40S subunits were not coimmunoprecipitated. Using this coprecipitation technique and pulse-chase labeling of ribosomal subunit proteins we showed that Nmd3p bo...

  2. Supporting seamless mobility for P2P live streaming.

    Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

    2014-01-01

    With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme. PMID:24977171

  3. Addressing the P2P Bootstrap Problem for Small Networks

    Wolinsky, David Isaac; Boykin, P Oscar; Figueiredo, Renato

    2010-01-01

    P2P overlays provide a framework for building distributed applications consisting of few to many resources with features including self-configuration, scalability, and resilience to node failures. Such systems have been successfully adopted in large-scale services for content delivery networks, file sharing, and data storage. In small-scale systems, they can be useful to address privacy concerns and for network applications that lack dedicated servers. The bootstrap problem, finding an existing peer in the overlay, remains a challenge to enabling these services for small-scale P2P systems. In large networks, the solution to the bootstrap problem has been the use of dedicated services, though creating and maintaining these systems requires expertise and resources, which constrain their usefulness and make them unappealing for small-scale systems. This paper surveys and summarizes requirements that allow peers potentially constrained by network connectivity to bootstrap small-scale overlays through the use of e...

  4. Behavioural Correlation for Detecting P2P Bots

    Al-Hammadi, Yousof; Aickelin, Uwe

    2010-01-01

    In the past few years, IRC bots, malicious programs which are remotely controlled by the attacker through IRC servers, have become a major threat to the Internet and users. These bots can be used in different malicious ways such as issuing distributed denial of services attacks to shutdown other networks and services, keystrokes logging, spamming, traffic sniffing cause serious disruption on networks and users. New bots use peer to peer (P2P) protocols start to appear ...

  5. On Reducing Delays in P2P Live Streaming Systems

    Huang, Fei

    2010-01-01

    In the recent decade, peer-to-peer (P2P) technology has greatly enhanced the scalability of multimedia streaming on the Internet by enabling efficient cooperation among end-users. However, existing streaming applications are plagued by the problems of long playback latency and long churn-induced delays. First of all, many streaming applications, such as IPTV and video conferencing, have rigorous constraints on end-to-end delays. Moreover, churn-induced delays, including delays from channel sw...

  6. Addressing the P2P Bootstrap Problem for Small Networks

    Wolinsky, David Isaac; Juste, Pierre St.; Boykin, P. Oscar; Figueiredo, Renato

    2010-01-01

    P2P overlays provide a framework for building distributed applications consisting of few to many resources with features including self-configuration, scalability, and resilience to node failures. Such systems have been successfully adopted in large-scale services for content delivery networks, file sharing, and data storage. In small-scale systems, they can be useful to address privacy concerns and for network applications that lack dedicated servers. The bootstrap problem, finding an existi...

  7. An Efficient Secure Multicast Communication for P2P Network

    Huaiqing Lin

    2011-03-01

    Full Text Available A new algorithm for efficient key management for secure group communication in P2P network is presented. The protocol avoids the escrow problem in identity-based cryptosystem and the secure delivery of private keys. It has two rounds and requires constant pairing operation per user. The security of protocol is based on some underlying problems closely related to the Bilinear Diffie-Hellman Problem are computationally hard.  

  8. Inclusive χ(2P) production in Υ(3S) decay

    Using the CsI calorimeter of the CLEO II detector, the spin triplet χb(2P) states are observed in Υ(3S) radiative decays with much higher statistics than seen in previous experiments. The observed mass splittings are not described well by theoretical models, while the relative branching ratios agree with predictions that include relativistic corrections to the radiative transition rates

  9. A P2P streaming service architecture with distributed caching

    GUO Pan-hong; YANG Yang; LI Xin-you

    2007-01-01

    Multimedia streaming served through peer-to-peer (P2P) networks is booming nowadays. However, the end-to-end streaming quality is generally unstable due to the variability of the state of serve-peers. On the other hand, proxy caching is a bandwidth-efficient scheme for streaming over the Internet, whereas it is a substantially expensive method needing dedicated powerful proxy servers. In this paper, we present a P2P cooperative streaming architecture combined with the advantages of both P2P networks and multimedia proxy caching techniques to improve the streaming quality of participating clients. In this framework, a client will simultaneously retrieve contents from the server and other peers that have viewed and cached the same title before. In the meantime, the client will also selectively cache the aggregated video content so as to serve still future clients. The associate protocol to facilitate the multi-path streaming and a distributed utility-based partial caching scheme are detailedly discussed. We demonstrate the effectiveness of this proposed architecture through extensive simulation experiments on large, Internet-like topologies.

  10. DNA Compaction by Yeast Mitochondrial Protein ABF2p

    Friddle, R W; Klare, J E; Noy, A; Corzett, M; Balhorn, R; Baskin, R J; Martin, S S; Baldwin, E P

    2003-05-09

    We used high resolution Atomic Force Microscopy (AFM) to image compaction of linear and circular DNA by the yeast mitochondrial protein ABF2p , which plays a major role in maintaining mitochondrial DNA. AFM images show that protein binding induces drastic bends in the DNA backbone for both linear and circular DNA. At high concentration of ABF2p DNA collapses into a tight globular structure. We quantified the compaction of linear DNA by measuring the end-to-end distance of the DNA molecule at increasing concentrations of ABF2p. We also derived a polymer statistical mechanics model that gives quantitative description of compaction observed in our experiments. This model shows that a number of sharp bends in the DNA backbone is often sufficient to cause DNA compaction. Comparison of our model with the experimental data showed excellent quantitative correlation and allowed us to determine binding characteristics for ABF2. Our studies indicate that ABF2 compacts DNA through a novel mechanism that involves bending of DNA backbone. We discuss the implications of such a mechanism for mitochondrial DNA maintenance.

  11. Accurate long-range coefficients for two excited like isotope He atoms: He(2 1P)-He(2 1P), He(2 1P)-He(2 3P), and He(2 3P)-He(2 3P)

    A general formalism is used to express the long-range potential energies in inverse powers of the separation distance between two like atomic or molecular systems with P symmetries. The long-range molecular interaction coefficients are calculated for the molecular symmetries Δ, Π, and Σ, arising from the following interactions: He(2 1P)-He(2 1P), He(2 1P)-He(2 3P), and He(2 3P)-He(2 3P). The electric quadrupole-quadrupole term C5, the van der Waals (dispersion) term C6, and higher-order terms C8 and C10 are calculated ab initio using accurate variational wave functions in Hylleraas coordinates with finite nuclear mass effects. A comparison is made with previously published results where available

  12. Relativistic calculations of 3s21S0-3s3p 1P1 and 3s21S0-3s3p 3P1,2 transition probabilities in the Mg isoelectronic sequence

    Using the multi-configuration Dirac—Fock self-consistent field method and the relativistic configuration-interaction method, calculations of transition energies, oscillator strengths and rates are performed for the 3s21S0-3s3p 1P1 spin-allowed transition, 3s21S0-3s3p 3P1,2 intercombination and magnetic quadrupole transition in the Mg isoelectronic sequence (Mg I, Al II, Si III, P IV and S V). Electron correlations are treated adequately, including intravalence electron correlations. The influence of the Breit interaction on oscillator strengths and transition energies are investigated. Quantum electrodynamics corrections are added as corrections. The calculation results are found to be in good agreement with the experimental data and other theoretical calculations. (atomic and molecular physics)

  13. Hermes, a collaborative environment at IN2P3

    Helft, Christian, E-mail: helft@lal.in2p3.f [Laboratoire de l' Accelerateur Lineaire Bat 200 91898 ORSAY Cedex (France)

    2010-04-01

    IN2P3, the institute bringing together HEP laboratories in France, opened a videoconferencing service in 2002 based on an industry standard H323 MCU (Multiple Control Unit). This service has steadily grown since then, serving other French scientific communities in addition to HEP and reaching an average of about thirty conferences a day. The relatively small amount of manpower required to deploy and maintain this facility can be explained by the very sound design and the large array of built-in capabilities offered by the equipment that replaced the original equipment purchased in 2005.

  14. Gestor de almacenamiento en redes P2P

    Olías de Lima Pancorbo, Carlos

    2009-01-01

    El objetivo del proyecto consiste en la implementación de un sistema de archivos distribuido mediante P2P, basándose en el entorno de desarrollo .NET. Para dicho desarrollo, la primera parte del proyecto consiste en la familiarización con un nuevo lenguaje de desarrollo integrado en la plataforma Visual Studio: Visual Basic.NET. En segundo lugar, una vez adquiridos los conocimientos necesarios para el desarrollo de aplicaciones en dicha plataforma, se implementará un Sistema de Archivos Distr...

  15. Theory of photoemission from the Ni 2p core level

    Photoemission spectra are calculated for the Ni 2p core level within a small-cluster many-body scheme. The interplay between Coulomb, exchange, and spin-orbit interactions is discussed, as well as the role of extra-atomic screening. The spin-dependent transfer of spectral weight, both within and across the levels, is considered. Effects due to circular, linear, and unpolarized excitation are also examined. Local final-state configurations are reported, and a physical interpretation of the various spectral features is given. copyright 1997 The American Physical Society

  16. Random walk search in unstructured P2P

    Jia Zhaoqing; You Jinyuan; Rao Ruonan; Li Minglu

    2006-01-01

    Unstructured P2P has power-law link distribution, and the random walk in power-law networks is analyzed. The analysis results show that the probability that a random walker walks through the high degree nodes is high in the power-law network, and the information on the high degree nodes can be easily found through random walk. Random walk spread and random walk search method (RWSS) is proposed based on the analysis result. Simulation results show that RWSS achieves high success rates at low cost and is robust to high degree node failure.

  17. KⅧ-TbLⅣ离子3s3p 3P1-3s2 1S0 的自旋禁戒跃迁%Intercombination Transitions 3s3p 3P1-3s2 1S0 in Magnesium-like Ions through KⅧ to TbLⅣ

    牟致栋; 魏琦瑛

    2004-01-01

    在对KⅧ-TbLⅣ离子3s3p 3P1能级结构的多组态相互作用理论HXR方法计算的基础上, 分析了各种效应对等电子序列离子能级结构的影响, 找出了能级沿等电子序列变化的规律性. 预测计算了K Ⅷ-Tb LⅣ离子3s3p 3P1的能级. 由此进一步计算了KⅧ-TbL Ⅳ离子自旋禁戒跃迁3s3p 3P1-3s2 1S0的谱线波长、振子强度和跃迁概率.

  18. Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosis

    Mant, Alexandra; Williams, Sarah; O'Kelly, Ita

    2013-01-01

    Acid-sensitive, two-pore domain potassium channels, K2p3.1 and K2p9.1, are implicated in cardiac and nervous tissue responses to hormones, neurotransmitters and drugs. K2p3.1 and K2p9.1 leak potassium from the cell at rest and directly impact membrane potential. Hence altering channel number on the cell surface drives changes in cellular electrical properties. The rate of K2p3.1 and K2p9.1 delivery to and recovery from the plasma membrane determines both channel number at the cell surface and...

  19. Ab-initio multi-configuration Dirac-Hartree-Fock calculation on the lifetimes of levels in 2p53s configuration of neutral neon

    Large-scale calculations have been performed using the GRASP2K package to accurately determine the lifetime of levels in 2p53s configuration of neutral neon. In particular, we calculated the hyperfine-induced transition rates from two metastable levels 3P20,0 to the ground state for odd Ne isotopes. It was found that hyperfine interactions drastically quench the lifetime of these two levels.

  20. Syntenic homology of human unique DNA sequences within chromossome regions 5q31, 10q22, 13q32-33 and 19q13.1 in the great apes

    Vallente-Samonte Rhea U.; Conte Robert A.; Verma Ram S.

    2000-01-01

    Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1) led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR), gorilla (Gorilla gorilla, GGO) and orangutan (Pongo pygmaeus, PPY) chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to...

  1. Complexes of (EtO)2P(O)CH2P(O)(OEt)2 with lanthanide nitrates

    The preparation of complexes of (EtO)2P(O)CH2P(O)(OEt)2 = L, with lanthanide nitrates is described. Stable complexes with composition LnL2(NO3)3 can be isolated for Ln = La-Eu and fully characterised. For LnGd-Lu solid compounds could not be isolated. Conductivity and 31P NMR spectroscopy indicate structural changes in solution between the lighter and heavier lanthanides and, whilst electro-spray mass spectrometry confirms a dramatic difference in behaviour with complexes of the heavier lanthanides readily decomposing via loss of EtNO3, other experiments show that this does not occur under the conditions of complex formation. The single crystal X-ray structures for Ln = La and Sm show the nitrates and OEt groups to be in close proximity. The changes in spectroscopic properties correlate well with the difficulties in isolating the complexes of heavier metals, and are possibly due to the formation of dimeric complexes rather than loss of ethyl nitrate. (authors)

  2. The direct measurement of the 3 3P0-3 3P1 fine-structure interval and the gJ-factor of atomic silicon by laser magnetic resonance

    Evenson, K. M.; Beltran-Lopez, V.; Ley-Koo, E.; Inguscio, M.

    1984-01-01

    The J - 1 fine structure interval and the g-factor of the 3P1 state have been determined with high precision in the present laser magnetic resonance measurements of the ground 3p2 3P multiplet of atomic Si. Delta-E(3P1-3P0) = 2,311,755.6(7) MHz, and gJ(3P1) = 1.500830(70). Single-configuration calculations of gJ for 3P1 and 3P2 yield a value for the latter which, at 1.501095, is noted to differ by an unexpectedly large margin from the experimental value.

  3. Content Distribution Mechanism in Mobile P2P Network

    Degui Zeng

    2014-05-01

    Full Text Available As content distribution in mobile P2P network facing architecture instability, the limited ability of a single node, low efficiency of content distribution and other problems, this paper proposes a new mobile network structure and content distribution mechanism strategy, the new mobile network structure will be divided into multiple subnets network for partition management. Each subnet manages information routing and dissemination strategies through a super-node. The transfer of information between subnets can be achieved by transitional node in cross region. Thus the information transfer is achieved in the entire network. Content distribution strategies using part of network coding mechanism for data compression, improve the efficiency of information transmission and download success rate. Finally, experimental verification, the experimental results show that: the proposed new mobile network structure and content distribution mechanisms strategies can reduce the disturbance of download success rate caused by fixed point, reduce the data transmission delay, and effectively improve the hit rate

  4. P2P Approach for Web Services Publishing and Discovery

    Islam, Mohmammad Towhidul; Akon, Mursalin; Shen, Xuemin (Sherman)

    Web service is an emerging paradigm for distributing business applications from different platforms to a wide variety of clients. The critical factor in seamlessly accessing web services is to discover the appropriate service and the related service providers. Unfortunately, current web service technologies use centralized directory to keep the service index, which is not scalable and at the same time vulnerable to single point of failure. Peer to peer system is a popular decentralized architecture which can be used for key look up service with scalability and self organization. Thus there is an opportunity to intersect the P2P framework with web services to provide the scalable solution. In this chapter, we discuss the key methods to deploy web services using the peer-to-peer technology.

  5. Medium Effects in Cooling of Neutron Stars and $3P_2$ Neutron Gap

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``nuclear medium cooling'' scenario is in favor of a suppressed value of the $3P_2$ neutron gap.

  6. A case of 3p deletion syndrome associated with cerebellar hemangioblastoma.

    Suzuki-Muromoto, Sato; Hino-Fukuyo, Naomi; Haginoya, Kazuhiro; Kikuchi, Atsuo; Sato, Hiroki; Sato, Yuko; Nakayama, Tojo; Kubota, Yuki; Kakisaka, Yosuke; Uematsu, Mitsugu; Kumabe, Toshihiro; Md, Shigeo Kure

    2016-02-01

    We described clinical course of a 24-year-old woman with 3p deletion syndrome associated with cerebellar hemangioblastoma at the age of 16 years old. She presented dysmorphic facial features, growth retardation and severe psychomotor retardation associated with 3p deletion syndrome. We identified de novo 3p deletion encompassing p25 by using array-based comparative genomic hybridization, where causative gene of von Hippel-Lindau (VHL) disease located. Surgical therapy for cerebellar hemangioblastoma was performed, and histological examination was consistent in cerebellar hemangioblastoma. She showed no other tumors associated VHL disease till 24 years old. This is the first case report of a patient with 3p deletion syndrome whose cerebellar hemangioblastoma may be associated with VHL disease. Repeat imaging studies were recommended for the patients with 3p deletion syndrome. PMID:26365017

  7. Formation and decay of (3P(J))O atoms in the laser flash photolysis of chlorine dioxide (OClO) at 308 nm

    Colussi, A. J.

    1990-01-01

    The quantum yields of O(3P(J)) and Cl(2P(3/2)) atoms released in the laser flash photolysis of OClO at 308 and 298 K were determined and the kinetics of the subsequent oxygen atom decay was investigated using time-resolved atomic resonance fluorescence measurements. The results are consistent with the formation of sym-ClO3 having a Delta Hf(ClO3) (formed in the reaction O + OClO + Ar) of 55.6 +/-4 kcal/mol.

  8. Further evidence for clustering of human GABA[sub A] receptor subunit genes: Localization of the [alpha][sub 6]-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis

    Hicks, A.A.; Kamphuis, W.; Darlison, M.G. (MRC Molecular Neurobiology Unit, Cambride (United Kingdom)); Bailey, M.E.S.; Johnson, K.J. (Charing Cross and Westminster Medical School, London (United Kingdom)); Riley, B.P. (St. Mary' s Hospital Medical School, London (United Kingdom)); Siciliano, M.J. (Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States))

    1994-03-15

    GABA[sub A] receptors are hetero-oligomeric ion-channel complexes that are composed of combinations of [alpha], [beta], [gamma], and [delta] subunits and play a major role in inhibitory neurotransmission in the mammalian brain. The authors report here a microsatellite polymorphism within the human [alpha][sub 6]-subunit gene (GABRA6). Mapping of this marker in a human-hamster hybrid cell-line panel and typing of the repeat in the Centre d'Etude du Polymorphisme Humain (CEPH) reference families enabled the localization of this gene to chromosome 5q and established its linkage to the GABA[sub A] receptor [alpha][sub 1]-subunit gene (GA-BRA1) with a maximum lod score (Z[sub max]) of 39.87 at a [theta] of 0.069 (males) and 0.100 (females). These results reveal the clustering of GABRA6, GABRA1, and the GABA[sub A] receptor [gamma][sub 2]-subunit gene (GABRG2) on distal chromosome 5q. 17 refs., 1 fig., 1 tab.

  9. Identification of lysines within membrane-anchored Mga2p120 that are targets of Rsp5p ubiquitination and mediate mobilization of tethered Mga2p90

    Bhattacharya, Sabyasachi; Shcherbik, Natalia; Vasilescu, Julian; Smith, Jeffrey C.; Figeys, Daniel; Haines, Dale S.

    2008-01-01

    Mga2p90 is an endoplasmic reticulum (ER) localized transcription factor that is released from the ER membrane by a unique ubiquitin-dependent mechanism. Mga2p90 mobilization requires poly-ubiquitination of its associating membrane-bound Mga2p120 anchor and subsequent Mga2p120-Mga2p90 complex disassembly that is mediated by ATPase Cdc48p and its heteromeric ubiquitin-binding adaptor Npl4p-Ufd1p. Although previous studies have identified the ubiquitin ligase (i.e. Rsp5p) and ligase binding site...

  10. Ge 3P 6Si 2O 25: A cage structure closely related to the intersecting tunnel structure KMo 3P 6Si 2O 25

    Leclaire, A.; Raveau, B.

    1988-08-01

    A germanosilicophosphate Ge 3P 6Si 2O 25 has been isolated. Its structure was solved from a single-crystal study in the space group P overline31c . Its cell parameters are a = b = 7.994(1) Å, c = 16.513(2) Å, Z = 2. The refinement by full-matrix least-squares calculations leads to R = 0.043 with 686 independent reflections. The structure of this oxide is built up from corner-sharing PO 4 and SiO 4 tetrahedra and GeO 6 octahedra. One observes a feature common to several silicophosphates: the presence of the structural unit P 6Si 2O 25 built up from a disilicate group sharing its corners with six PO 4 tetrahedra. The structural relationships between this oxide and the silicophosphates AMo 3P 6Si 2O 25 and Si 3P 6Si 2O 25 (or Ge 3P 6 Ge 2O 25) are described.

  11. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.

    Thayer, Kelly M; Beyer, George A

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  12. Stark broadening of 3s 3P0-3p 3D and 3p 3D-3d 3F0 transitions along carbon isoelectronic sequences of ions revisited

    The Stark widths of N II and O III spectral lines belonging to 3s 3P0-3p 3D and 3p 3D-3d 3F0 multiplets have been calculated and measured in a capillary discharge plasma. The calculations are extended to the same multiplets of F IV and Ne V ions. The plasma electron density in the capillary discharge is determined from the width of the He II Pβ line, while the electron temperature is measured from the relative intensities of N II lines. A comparison of the experimental and theoretical data shows good mutual agreement, which is well within the estimated experimental and theoretical uncertainties. The theory predicts the ratio of the corresponding N II to O III line widths to be larger than unity, in disagreement with our earlier experiment in a pulsed arc. In the new experiment, where all spectral lines were recorded under the same plasma conditions, the theoretical predictions and the results of the capillary experiment are in agreement. The possible sources of an error in the earlier experiment are indicated

  13. Ternary complex formation of Ino2p-Ino4p transcription factors and Apl2p adaptin beta subunit in yeast.

    Nikawa, Jun-ichi; Yata, Masako; Motomura, Miki; Miyoshi, Nobutaka; Ueda, Tsuyoshi; Hisada, Daisuke

    2006-11-01

    Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Apl2p is a large subunit of the yeast adaptin complex, an adaptor complex required for the clathrin coat to bind to the membrane. We found that Ino2p, Ino4p, and Apl2p form a ternary complex. This interaction was initially observed in a yeast two-hybrid study and subsequently verified by co-immunoprecipitation. Ino2p and Ino4p bind to Apl2p in the same region of Apl2p, viz., at the middle part and the C-terminal part. Ino2p and Ino4p bind to Apl2p independently, but more strongly when both are present. Furthermore, a disruption of APL2 together with INO2 or INO4 rendered yeast cells sensitive to oxidative stress. INO2-APL2 double disruptants also showed growth inability in non-fermentable carbon sources, such as glycerol. These results indicate a genetic interaction between APL2, INO2 and INO4 and uncovere novel functions of the Ino2p-Ino4p-Apl2p complex in yeast. PMID:17090927

  14. Electronic and Rovibrational Quantum Chemical Analysis of C$_3$P$^-$: The Next Interstellar Anion?

    Fortenberry, Ryan C

    2015-01-01

    C$_3$P$^-$ is analogous to the known interstellar anion C$_3$N$^-$ with phosphorus replacing the nitrogen in a simple step down the periodic table. In this work, it is shown that C$_3$P$^-$ is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C$_3$P$^-$ has a valence excited state that may lead to further stabilization of this molecule, and C$_3$P$^-$ has a larger dipole moment than neutral C$_3$P ($\\sim 6$ D vs. $\\sim 4$ D). As such, C$_3$P$^-$ is probably a more detectable astromolecule than even its corresponding neutral radical. Highly-accurate quantum chemical quartic force fields are also applied to C$_3$P$^-$ and its singly $^{13}$C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  15. Electronic and rovibrational quantum chemical analysis of C3P-: the next interstellar anion?

    Fortenberry, Ryan C.; Lukemire, Joseph A.

    2015-11-01

    C3P- is analogous to the known interstellar anion C3N- with phosphorus replacing nitrogen in a simple step down the periodic table. In this work, it is shown that C3P- is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C3P- has a valence excited state that may lead to further stabilization of this molecule, and C3P- has a larger dipole moment than neutral C3P (˜6 D versus ˜4 D). As such, C3P- is probably a more detectable astromolecule than even its corresponding neutral radical. Highly accurate quantum chemical quartic force fields are also applied to C3P- and its singly 13C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  16. An Effective Calculation of Reputation in P2P Networks

    RVVSV Prasad

    2009-07-01

    Full Text Available With the advent of sophisticated networking technologies and the related applications, more and more computers are getting hooked to the Internet. This is mainly for utilizing several services ranging from information sharing to electronic transactions. P2P networks which allow decentralized systems, have posed problems related to trust when transactions have to be carried out. Current literature proposes several solutions for trust management and reputation computation. The solutions base their assessment of reputations on the number of successful transactions or on the similarity of the feedbacks. There are some concerns in the feedback ratings if we are not considering the issues like number of transactions, frequency of transactions with the same peer and different peers, age of transaction, how frequently a given peer attends a common vendor, and the number of common vendors between the pairs. This paper puts forward a reputation computation system addressing these concerns. It implicitly allows detection of malicious peers. It also incorporates a corrective mechanism, if the feedbacks are from more number of malicious peers. The implementations and the results that support our claims are also presented.

  17. Survey on Distributed Data Mining in P2P Networks

    T, Rekha Sunny

    2012-01-01

    The exponential increase of availability of digital data and the necessity to process it in business and scientific fields has literally forced upon us the need to analyze and mine useful knowledge from it. Traditionally data mining has used a data warehousing model of gathering all data into a central site, and then running an algorithm upon that data. Such a centralized approach is fundamentally inappropriate due to many reasons like huge amount of data, infeasibility to centralize data stored at multiple sites, bandwidth limitation and privacy concerns. To solve these problems, Distributed Data Mining (DDM) has emerged as a hot research area. Careful attention in the usage of distributed resources of data, computing, communication, and human factors in a near optimal fashion are paid by distributed data mining. DDM is gaining attention in peer-to-peer (P2P) systems which are emerging as a choice of solution for applications such as file sharing, collaborative movie and song scoring, electronic commerce, an...

  18. Sizeable beta-strength in {sup 31}Ar (β3p) decay

    Koldste, G.T. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Blank, B. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Borge, M.J.G.; Briz, J.A.; Carmona-Gallardo, M. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Fraile, L.M. [Grupo de Física Nuclear, Universidad Complutense, CEI Moncloa, E-28040 Madrid (Spain); Fynbo, H.O.U. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Giovinazzo, J. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Johansen, J.G. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Jokinen, A. [Department of Physics, University of Jyväskylä, FIN-40351 Jyväskylä (Finland); Jonson, B. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Kurturkian-Nieto, T. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Nilsson, T. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Perea, A.; Pesudo, V. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); and others

    2014-10-07

    We present for the first time precise spectroscopic information on the recently discovered decay mode β-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow–Teller strength distribution from the decay of {sup 31}Ar revealing that as much as 30% of the strength resides in the β3p-decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in {sup 31}Cl is provided.

  19. Progress on the Multiphysics Capabilities of the Parallel Electromagnetic ACE3P Simulation Suite

    Kononenko, Oleksiy [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-03-26

    ACE3P is a 3D parallel simulation suite that is being developed at SLAC National Accelerator Laboratory. Effectively utilizing supercomputer resources, ACE3P has become a key tool for the coupled electromagnetic, thermal and mechanical research and design of particle accelerators. Based on the existing finite-element infrastructure, a massively parallel eigensolver is developed for modal analysis of mechanical structures. It complements a set of the multiphysics tools in ACE3P and, in particular, can be used for the comprehensive study of microphonics in accelerating cavities ensuring the operational reliability of a particle accelerator.

  20. Sizeable beta-strength in 31Ar (beta 3p) decay

    T. Koldste, G.; Blank, B.; J. G. Borge, M.;

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as...... much as 30% of the strength resides in the beta-3p decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in 31Cl is provided....

  1. Attention-Deficit/Hyperactivity Disorder in a Population Isolate: Linkage to Loci at 4q13.2, 5q33.3, 11q22, and 17p11

    Arcos-Burgos, Mauricio; Castellanos, F. Xavier; Pineda, David; Lopera, Francisco; David Palacio, Juan; Guillermo Palacio, Luis; Rapoport, Judith L.; Berg, Kate; Bailey-Wilson, Joan E.; Muenke, Maximilian

    2004-01-01

    Attention-deficit/hyperactivity disorder (ADHD [MIM 143465]) is the most common behavioral disorder of childhood. Twin, adoption, segregation, association, and linkage studies have confirmed that genetics plays a major role in conferring susceptibility to ADHD. We applied model-based and model-free linkage analyses, as well as the pedigree disequilibrium test, to the results of a genomewide scan of extended and multigenerational families with ADHD from a genetic isolate. In these families, ADHD is highly comorbid with conduct and oppositional defiant disorders, as well as with alcohol and tobacco dependence. We found evidence of linkage to markers at chromosomes 4q13.2, 5q33.3, 8q11.23, 11q22, and 17p11 in individual families. Fine mapping applied to these regions resulted in significant linkage in the combined families at chromosomes 4q13.2 (two-point allele-sharing LOD score from LODPAL = 4.44 at D4S3248), 5q33.3 (two-point allele-sharing LOD score from LODPAL = 8.22 at D5S490), 11q22 (two-point allele-sharing LOD score from LODPAL = 5.77 at D11S1998; multipoint nonparametric linkage [NPL] −log [P value] = 5.49 at ∼128 cM), and 17p11 (multipoint NPL −log [P value] >12 at ∼12 cM; multipoint maximum location score 2.48 [α = 0.10] at ∼12 cM; two-point allele-sharing LOD score from LODPAL = 3.73 at D17S1159). Additionally, suggestive linkage was found at chromosome 8q11.23 (combined two-point NPL−log [P value] >3.0 at D8S2332). Several of these regions are novel (4q13.2, 5q33.3, and 8q11.23), whereas others replicate already-published loci (11q22 and 17p11). The concordance between results from different analytical methods of linkage and the replication of data between two independent studies suggest that these loci truly harbor ADHD susceptibility genes. PMID:15497111

  2. MPI spectroscopy in the region of the 3p Rydberg state of some cycloketones

    Kosmidis, C.; Boulakis, G.; Bolovinos, A.; Tsekeris, P.; Brint, P.

    1992-03-01

    The two-photon resonance three photon ionization spectra of cyclopentanone, cyclohexanone and cycloheptanone in the region of the 3p Rydberg state have been recorded, analysed and compared with the one-photon absorption spectra. A new 3p origin is identified for cyclopentanone. The absence from the MPI spectra of a sharp spectral feature that is observed in the absorption spectra is discussed. Photochemical generation of acetaldehyde is observed at high laser intensities and possible mechanisms for this are considered.

  3. miR-1207-3p Is a Novel Prognostic Biomarker of Prostate Cancer.

    Das, Dibash K; Osborne, Joseph R; Lin, Hui-Yi; Park, Jong Y; Ogunwobi, Olorunseun O

    2016-06-01

    MicroRNAs (miRNAs) have been found to be dysregulated in prostate cancer (PCa). In this study, we investigated if miR-1207-3p is capable of distinguishing between indolent and aggressive PCa and if it contributes to explaining the disproportionate aggressiveness of PCa in men of African ancestry (moAA). A total of 404 patients with primary adenocarcinoma of the prostate were recruited between 1988 and 2003 at the Moffitt Cancer Center, Tampa, FL, USA. Patient clinicopathological features and demographic characteristics such as race were identified. RNA samples from 404 postprostatectomy prostate tumor tissue samples were analyzed by real-time quantitative reverse transcription polymerase chain reaction for the mRNA expression of miR-1207-3p. miR-1207-3p expression in PCa that resulted in overall death or PCa-specific death is significantly higher than in PCa cases that did not. The same positive correlation holds true for other clinical characteristics such as biochemical recurrence, Gleason score, clinical stage, and prostate-specific antigen level. Furthermore, miR-1207-3p expression was significantly less in moAA in comparison to Caucasian men. We also evaluated whether miR-1207-3p is associated with clinical outcomes adjusted for age at diagnosis and tumor stage in the modeling. Using competing risk regression, the PCa patients with a high miR-1207-3p expression (≥6 vs 3) had a high risk to develop PCa recurrence (hazard rate = 2.5, P < .001) adjusting for age at diagnosis and tumor stage. In conclusion, miR-1207-3p is a promising novel prognostic biomarker for PCa. Furthermore, miR-1207-3p may also be important in explaining the disproportionate aggressiveness of PCa in moAA. PMID:27267842

  4. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    Aibing WU

    2015-07-01

    Full Text Available Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in NSCLC tissues and lung adenocarcinoma cell lines was detected by quantitative reverse transcription polymerase chain reaction. The roles of miR-373-3p in regulating lung adenocarcinoma cell invasion and metastatic properties were analyzed with miR-373-3p mimic/inhibitor-transfected cells via Transwell chamber assay. Matrix metalloproteinase MMP-9 and MMP-14 protein levels were detected by Western blot in lung cancer cells after transfection. Results MiR-373-3p was upregulated in 51 NSCLC tissues and 5 NSCLC cell lines. Gain-of-function and loss-of-function studies showed that overexpression of miR-373-3p promoted H1299 cell migration and invasion, which resulted in upregulation of MMP-9 and MMP-14. By contrast, miR-373-3p knockdown inhibited these processes in A549 cells and downregulated the expression of MMP-9 and MMP-14. Conclusion Our results demonstrated that miR-373-3p participated in the invasion and metastasis of lung adenocarcinoma cells, partly by upregulation of MMP-9 and MMP-14.

  5. Determination of diffusion, reflection and deexcitation coefficients of metastable excited Ne(3P2) atom

    Suzuki, S.; Itoh, H.

    2016-05-01

    The diffusion coefficient of the metastable excited Ne(3P2) atom in neon, the reflection coefficient of Ne(3P2) at the surface of an electrode and the rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) were determined from the gas pressure dependence of the effective lifetime of Ne(3P2). The effective lifetime of Ne(3P2) was measured from the transient current after turning off the Ultraviolet (UV) light in a Townsend discharge. The observed transient current waveform was analysed by solving the diffusion equation for the metastable excited Ne(3P2) atom using the third kind of boundary condition. The rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) and the reflection coefficient were determined by a nonspectroscopic method for the first time in neon to the best of our knowledge and were (3.2  ±  0.4)  ×  10‑16 cm3 s‑1 and 0.10  ±  0.04, respectively. The obtained diffusion coefficient at 1 Torr was 177  ±  17 cm2 s‑1, which is consistent with the value reported by Dixon and Grant. Moreover, the present results are compared with the results of Phelps and were found to be in good agreement. We also discuss the deexcitation rate of Ne(3P2) at pressures of up to 60 Torr in comparison with previously reported values.

  6. Ab-initio calculation of the 2s21S0-2s3p 3P1 intercombination transition in beryllium-like ions

    Transition probabilities of the 2s21S0-2s3p 1,3P1 intercombination and resonance lines have been calculated for 14 beryllium-like ions in the atomic range 7 ≤ Z ≤ 36. We used multiconfiguration Dirac-Fock wave functions to explore the effects of configuration interaction, of electron rearrangement as well as of relativity in a consistent scheme along the isoelectronic sequence. To show the number of configurations needed in a proper expansion of the wave functions we systematically enlarged the basis from small to large-scale. For the low-Z elements, virtual excitations of the 2s and 3p electrons up to the 5l subshells contribute significantly to the intercombination probability even though the transition energies remain almost unaffected by excitations beyond the 3l shells. The incomplete orthogonality of the orbital functions due to the rearrangement of the electron density clearly shifts the intercombination rates and appears to be independent of the configuration expansion. This effect decreases, as expected, at higher nuclear charges. (orig.)

  7. miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma.

    Williams, Marissa; Kirschner, Michaela B; Cheng, Yuen Yee; Hanh, Jacky; Weiss, Jocelyn; Mugridge, Nancy; Wright, Casey M; Linton, Anthony; Kao, Steven C; Edelman, J James B; Vallely, Michael P; McCaughan, Brian C; Cooper, Wendy; Klebe, Sonja; Lin, Ruby C Y; Brahmbhatt, Himanshu; MacDiarmid, Jennifer; van Zandwijk, Nico; Reid, Glen

    2015-09-15

    Malignant pleural mesothelioma (MPM) is an asbestos-induced cancer with poor prognosis that displays characteristic alterations in microRNA expression. Recently it was reported that the expression of a subset of microRNAs can distinguish between MPM and adenocarcinoma of the lung. However, the functional importance of these changes has yet to be investigated. We compared expression of miR-192, miR-193a-3p and the miR-200 family in normal pleura and MPM tumor specimens and found a statistically significant reduction in the levels of miR-193a-3p (3.1-fold) and miR-192 (2.8-fold) in MPM. Transfection of MPM cells with a miR-193a-3p mimic resulted in inhibition of growth and an induction of apoptosis and necrosis in vitro. The growth inhibitory effects of miR-193a-3p were associated with a decrease in MCL1 expression and were recapitulated by RNAi-mediated MCL1 silencing. Targeted delivery of miR-193a-3p mimic using EDV minicells inhibited MPM xenograft tumour growth, and was associated with increased apoptosis. In conclusion, miR-193a-3p appears to have importance in the biology of MPM and may represent a target for therapeutic intervention. PMID:26125439

  8. Protective role of miR-23b-3p in kainic acid-induced seizure.

    Zhan, Lianbo; Yao, Yi; Fu, Huajun; Li, Zhenghui; Wang, Fengpeng; Zhang, Xiaobin; He, Wencan; Zheng, Weihong; Zhang, Yunwu; Zheng, Honghua

    2016-07-01

    Dysregulation of microRNAs has been proposed to contribute toward epilepsy. The miRNA miR-23b-3p has been found to protect against neuronal apoptosis and the production of reactive oxygen species. In this study, we assessed the potential role of miR-23b-3p in the kainic acid (KA)-induced seizure model. We found that miR-23b-3p levels were significantly decreased in the brain cortex of mice and in cultured mouse primary neurons treated with KA. Importantly, supplement of miR-23b-3p agomir by an intacerebroventricular injection alleviated seizure behaviors and abnormal cortical electroencephalogram recordings in KA-treated mice. Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure. PMID:27232518

  9. Multiplex FISH telomere integrity assay identifies an unbalanced cryptic translocation der(5)t(3;5)(q27;p15.3) in a family with three mentally retarded individuals.

    Granzow, M; Popp, S; Keller, M; Holtgreve-Grez, H; Brough, M; Schoell, B; Rauterberg-Ruland, I; Hager, H D; Tariverdian, G; Jauch, A

    2000-07-01

    Cryptic rearrangements involving the terminal regions of chromosomes are suspected to be the cause of idiopathic mental retardation in a significant number of cases. This finding highlights the necessity of a primary screening test for such chromosome aberrations. Here we present a multiplex fluorescence in situ hybridization telomere integrity assay which allows the detection of submicroscopic aberrations in the telomeric regions of all chromosomes. This novel approach identified an unbalanced cryptic translocation der(5)t(3;5)(q27;p15.3) in a family with three cases of unexplained mental retardation and dysmorphic features. The symptoms of the patients represent neither the classical dup(3q)- nor cri du chat syndrome, although all affected individuals demonstrate several features of both syndromes. The identification of two balanced translocation carriers emphasizes the significance of the telomere integrity assay for genetic counseling and prenatal diagnosis. PMID:10982035

  10. Adaptive Routing Algorithms in Unstructured Peer-to-Peer (P2P) Systems

    Achmad Nizar Hidayanto; Stephane Bressan

    2011-01-01

    There are a variety of peer-to-peer (P2P) systems for sharing documents currently available. According to their data organization, P2P systems are classified into two categories: structured andunstructured P2P systems. In structured P2P systems, peers are organized according to some mapping techniques, e.g. hashing function. Whereas in unstructured P2P system, peers are connected to each others randomly; resources are not moved to other peers but hosted on site. Unstructured P2P systems offer...

  11. A Kumada Coupling Catalyst, [Ni{(Ph2P)2N(CH2)3Si(OCH3)3-P,P }Cl2], Bearing a Ligand for Direct Immobilization Onto Siliceous Mesoporous Molecular Sieves

    Stamatopoulos, I.; Giannitsios, D.; Psycharis, V.; Raptopoulou, C. P.; Balcar, Hynek; Zukal, Arnošt; Svoboda, J.; Kyritsis, P.; Vohlídal, J.

    2015-01-01

    Roč. 2015, č. 18 (2015), s. 3038-3044. ISSN 1434-1948 R&D Projects: GA ČR GAP108/12/1143 Institutional support: RVO:61388955 Keywords : homogenous catalysis * heterogeneous catalysis * cross coupling Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.942, year: 2014

  12. 3p14 De Novo Interstitial Microdeletion in a Patient with Intellectual Disability and Autistic Features with Language Impairment: A Comparison with Similar Cases

    Ana Belén de la Hoz

    2015-01-01

    Full Text Available To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. Here, we report a new case of a 3p proximal interstitial deletion. The patient is an 11-year-old female with speech and social interaction difficulties, learning disability, and slight facial dysmorphism, but no other major malformations. An 8 Mb de novo interstitial deletion at 3p14.2-p14.1, from position 60.461.316 to 68.515.453, was revealed by means of array comparative genomic hybridization and confirmed using quantitative reverse-transcription polymerase chain reaction assays. This region includes six genes: FEZF2, CADPS, SYNPR, ATXN7, PRICKLE, and MAGI1, that are known to have a role in neurodevelopment. These genes are located on the proximal side of the deletion. We compare our case with previously well-defined patients reported in the literature and databases.

  13. Increased miR-132-3p expression is associated with chronic neuropathic pain.

    Leinders, M; Üçeyler, N; Pritchard, R A; Sommer, C; Sorkin, L S

    2016-09-01

    Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance. We set out to analyze the role of miR-132-3p, first in patients with peripheral neuropathies and second in an animal model of neuropathic pain. We initially determined miR-132-3p expression by measuring its levels in white blood cells (WBC) of 30 patients and 30 healthy controls and next in sural nerve biopsies of 81 patients with painful or painless inflammatory or non-inflammatory neuropathies based on clinical diagnosis. We found a 2.6 fold increase in miR-132-3p expression in WBC of neuropathy patients compared to healthy controls (panimal model of neuropathic pain, the spared nerve injury model (SNI). For this purpose miR-132-3p expression levels were measured in dorsal root ganglia and spinal cord of rats. Subsequently, miR-132-3p expression was pharmacologically modulated with miRNA antagonists or mimetics, and evoked pain and pain aversion were assessed. Spinal miR-132-3p levels were highest 10days after SNI, a time when persistent allodynia was established (pbehavior in the place escape avoidance paradigm (pbehavior in naïve rats (p<0.001). Taken together these results indicate a pro-nociceptive effect of miR-132-3p in chronic neuropathic pain. PMID:27349406

  14. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.

    Prashant K Mishra

    2011-09-01

    Full Text Available The kinetochore (centromeric DNA and associated proteins is a key determinant for high fidelity chromosome transmission. Evolutionarily conserved Scm3p is an essential component of centromeric chromatin and is required for assembly and function of kinetochores in humans, fission yeast, and budding yeast. Overexpression of HJURP, the mammalian homolog of budding yeast Scm3p, has been observed in lung and breast cancers and is associated with poor prognosis; however, the physiological relevance of these observations is not well understood. We overexpressed SCM3 and HJURP in Saccharomyces cerevisiae and HJURP in human cells and defined domains within Scm3p that mediate its chromosome loss phenotype. Our results showed that the overexpression of SCM3 (GALSCM3 or HJURP (GALHJURP caused chromosome loss in a wild-type yeast strain, and overexpression of HJURP led to mitotic defects in human cells. GALSCM3 resulted in reduced viability in kinetochore mutants, premature separation of sister chromatids, and reduction in Cse4p and histone H4 at centromeres. Overexpression of CSE4 or histone H4 suppressed chromosome loss and restored levels of Cse4p at centromeres in GALSCM3 strains. Using mutant alleles of scm3, we identified a domain in the N-terminus of Scm3p that mediates its interaction with CEN DNA and determined that the chromosome loss phenotype of GALSCM3 is due to centromeric association of Scm3p devoid of Cse4p/H4. Furthermore, we determined that similar to other systems the centromeric association of Scm3p is cell cycle regulated. Our results show that altered stoichiometry of Scm3p/HJURP, Cse4p, and histone H4 lead to defects in chromosome segregation. We conclude that stringent regulation of HJURP and SCM3 expression are critical for genome stability.

  15. QTL Information Table: 5 [Q-TARO

    Full Text Available Physiological trait Eating quality Grain l/w ratio SSR C)Interval DH from BC3F1 Cai..., C., Bergman, C., and Oard, J.H. (2004). QTL mapping of grain quality traits from the interspecific cross Oryza sativa x O. glaberrima. Theor Appl Genet 109, 630-639. ...

  16. PbS/Cd3P2 quantum heterojunction colloidal quantum dot solar cells

    Here, we demonstrated the quantum heterojunction colloidal quantum dot (CQD) solar cells employing the PbS CQDs/Cd3P2 CQDs architecture in which both the p-type PbS and n-type Cd3P2 CQD layers are quantum-tunable and solution-processed light absorbers. We synthesized well-crystallized and nearly monodispersed tetragonal Cd3P2 CQDs and then engineered their energy band alignment with the p-type PbS by tuning the dot size and hence the bandgap to achieve efficient light absorbing and charge separation. We further optimized the device through the Ag-doping strategy of PbS CQDs that may leverage an expanded depletion region in the n-layer, which greatly enhances the photocurrent. The resulting devices showed an efficiency of 1.5%. (paper)

  17. A new form of Ca3P2 with a ring of Dirac nodes

    We report the synthesis and crystal structure of a new high-temperature form of Ca3P2. The crystal structure was determined through Rietveld refinements of synchrotron powder x-ray diffraction data. This form of Ca3P2 has a crystal structure of the hexagonal Mn5Si3 type, with a Ca ion deficiency compared to the ideal 5:3 stoichiometry. This yields a stable, charge-balanced compound of Ca2+ and P3−. We also report the observation of a secondary hydride phase, Ca5P3H, which again is a charge-balanced compound. The calculated band structure of Ca3P2 indicates that it is a three-dimensional Dirac semimetal with a highly unusual ring of Dirac nodes at the Fermi level. The Dirac states are protected against gap opening by a mirror plane in a manner analogous to what is seen for graphene

  18. BOREAS Level-3p Landsat TM Imagery: Geocoded and Scaled At-sensor Radiance

    Nickeson, Jaime; Knapp, David; Newcomer, Jeffrey A.; Hall, Forrest G. (Editor); Cihlar, Josef

    2000-01-01

    For BOReal Ecosystem-Atmosphere Study (BOREAS), the level-3p Landsat Thematic Mapper (TM) data were used to supplement the level-3s Landsat TM products. Along with the other remotely sensed images, the Landsat TM images were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy, detailed land cover, and biophysical parameter maps such as Fraction of Photosynthetically Active Radiation (FPAR) and Leaf Area Index (LAI). Although very similar to the level-3s Landsat TM products, the level-3p images were processed with ground control information, which improved the accuracy of the geographic coordinates provided. Geographically, the level-3p images cover the BOREAS Northern Study Area (NSA) and Southern Study Area (SSA). Temporally, the four images cover the period of 20-Aug-1988 to 07-Jun-1994. Except for the 07-Jun-1994 image, which contains seven bands, the other three contain only three bands.

  19. Influence of Optical Properties on the Spin Polarization of Cu3P Photoelectrons

    Chassé, A.; Niebergall, L.

    We have investigated the influence of optical properties of Cu(001) on the spin polarization in Cu3p photoelectron diffraction patterns. The refraction and absorption of light have been taken into account in the calculation of the dipole transition matrix element. Therefore, a general polarization vector of light is defined within a macroscopic theory of electromagnetic fields. Results are shown and discussed for Cu3p photoelectrons excited by linearly or circularly polarized light, respectively. It is shown that the optical behavior of crystals may cause a symmetry breaking in the angular dependence of the photoelectron intensity. Besides, there are strong quantitative changes in the related spin polarization of Cu3p photoelectrons.

  20. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families

    Kashevarova, Anna A; Nazarenko, Lyudmila P; Schultz-Pedersen, Soren; Skryabin, Nikolay A; Salyukova, Olga A; Chechetkina, Nataliya N; Tolmacheva, Ekaterina N; Rudko, Aleksey A; Magini, Pamela; Graziano, Claudio; Romeo, Giovanni; Joss, Shelagh; Tümer, Zeynep; Lebedev, Igor N

    2014-01-01

    BACKGROUND: Detection of submicroscopic chromosomal alterations in patients with a idiopathic intellectual disability (ID) allows significant improvement in delineation of the regions of the genome that are associated with brain development and function. However, these chromosomal regions usually...... contain several protein-coding genes and regulatory elements, complicating the understanding of genotype-phenotype correlations. We report two siblings with ID and an unrelated patient with atypical autism who had 3p26.3 microdeletions and one intellectually disabled patient with a 3p26.3 microduplication...

  1. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    Wu, Aibing; Jinmei LI; Kunpeng WU; Mo, Yanli; Luo, Yiping; Haiyin YE; Shen, Xiang; Li, Shujun; Yahai LIANG; Liu, Meilian; Yang, Zhixiong

    2015-01-01

    Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC) and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in...

  2. Domain architectures of the Scm3p protein provide insights into centromere function and evolution

    Aravind, L.; Lakshminarayan, M. Iyer; Wu, Carl

    2007-01-01

    Recently, Scm3p has been shown to be a nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3–H4 histones, and to be required for the assembly of kinetochores in S. cerevisiae. Scm3p is conserved across fungi, and displays a remarkable variation in protein size, ranging from ~200 amino acids in Saccharomyces cerevisiae to ~1300 amino acids in Neurospora crassa. This is primarily due a variable C-terminal segment that is linked to a conserved N-terminal, CenH3-int...

  3. Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles.

    Hoebeeck, Jasmien; De Wilde, Bram; Michels, Evi; Combaret, Valérie; Yigit, Nurten; De Smet, Els; Van Roy, Nadine; Stanbridge, Eric; Ru, Ning; Laureys, Geneviève; De Paepe, Anne; Speleman, Frank; Vandesompele, Jo

    2009-10-01

    Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells. PMID:19544108

  4. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    Friebe, Jan; Pape, André; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M.; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several ...

  5. Observation of the Forbidden Magnetic Dipole Transition 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} in Atomic Thallium

    Chu, S.

    1976-10-01

    A measurement of the 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} forbidden magnetic dipole matrix element in atomic thallium is described. A pulsed, linearly polarized dye laser tuned to the transition frequency is used to excite the thallium vapor from the 6{sup 2}P{sub ½} ground state to the 7{sup 2}P{sub ½} excited state. Interference between the magnetic dipole M1 amplitude and a static electric field induced E1 amplitude results in an atomic polarization of the 7{sup 2}P{sub ½} state, and the subsequent circular polarization of 535 nm fluorescence. The circular polarization is seen to be proportional to / as expected, and measured for several transitions between hyperfine levels of the 6{sup 2}P{sub ½} and 7{sup 2}P{sub ½} states. The result is = -(2.11 +- 0.30) x 10{sup -5} parallel bar e parallel bar dirac constant/2mc, in agreement with theory.

  6. Theoretical study of the photoionization of the excited 1s22s2p 1,3Po states of the Be-like B+ ion

    Photoionization of the first excited p states of the Be-like B+ ion, which interact with the even-parity continua, has been studied theoretically. The calculated photoionization cross sections contain a number of autoionizing Rydberg series of resonances converging to the B2+ 2p, 3s, 3p, and 3d states. Lower members of the Rydberg series of resonances with n≤12 are identified and resonance positions Er, effective quantum numbers n*, and widths Γ are presented. Excellent agreement between length- and velocity-gauge results is found, along with overall good agreement with previous work

  7. An agent-based incentive mechanism for P2P systems

    ZHANG Jian-feng; WANG Ru-chuan

    2006-01-01

    With the increasing uses of peer-to-peer (P2P)systems, the problems of fair information and resources sharing become serious. P2P systems are self-organizing,distributed systems with no centralized authority, such as Free-riding and Tragedy of Commons. Because of the voluntary participation and lack of motivation, the information and resources available in P2P networks are extremely variable and unpredictable. This article studied the problems existing in P2P networks and propose a different method to stimulate the peers in P2P networks to share information and resources,using agents so as to improve the performance of P2P networks.And through simulation experiments and analyzing the results,it can be concluded that this mechanism can effectively solve the problems of fair sharing in P2P systems.

  8. Endothelium-dependent relaxations in the aorta from K2p6.1 knockout mice

    Lloyd, Eric E.; Pandit, Lavannya M.; Crossland, Randy F.; Marrelli, Sean P.; Bryan, Robert M.

    2013-01-01

    K2P6.1 or TWIK-2, a two-pore domain K channel, is an important regulator of cardiovascular function. K2P6.1 is highly expressed in vascular smooth muscle and endothelium. Mice (8–12 wk) lacking functional K2P6.1 (K2P6.1−/−) are hypertensive and have enhanced vascular contractility. It is not known whether the lack of functional K2P6.1 in endothelium has a role in the vascular dysfunction in K2P6.1−/− mice. We tested the hypothesis: K2P6.1−/− mice have impaired endothelium-dependent relaxation...

  9. Electron impact investigation of the 3p-Rydberg transitions of acetone

    High resolution (15 meV), gas phase, electron impact energy loss spectra of acetone, and acetone-d6 measured as a function of incident energy and scattering angle have been used to study the anomalously weak 7.4 eV 3p-Rydberg transition in acetone. Assignments made on the basis of isotope shifts and differential electron scattering cross sections show that the weak transition observed optically and in the high energy electron impact spectrum is a forbidden transition to the out-of-plane 3p-Rydberg orbital. The band system is built on a vibronically allowed false origin enabled by the ν23 (CO bend) vibration. The analogous transition in the less symmetric molecule methyl ethyl ketone was observed to be optically allowed. All observed bands could be assigned to the one electronic transition to the out-of-plane 3p-Rydberg orbital. The other two 3p-Rydberg transitions do not appear to be active in acetone or methyl ethyl ketone. An unusual feature of this investigation was the experimental investigation of the relative differential scattering cross sections of both true and false vibronic origins within a single electronic transition. The high energy resolution allowed isotopic substitution, a traditional technique of optical spectroscopy, to be used to establish assignments in an electron impact experiment

  10. Synthesization of the Ar VIII 3s-3p beam-foil decay curve

    The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

  11. Canine-Origin G3P[3] Rotavirus Strain in Child with Acute Gastroenteritis

    De Grazia, Simona; Martella, Vito; Giammanco, Giovanni M; Gòmara, Miren Iturriza; Ramirez, Stefania; Cascio, Antonio; Colomba, Claudia; Arista, Serenella

    2007-01-01

    Infection by an animal-like strain of rotavirus (PA260/97) was diagnosed in a child with gastroenteritis in Palermo, Italy, in 1997. Sequence analysis of VP7, VP4, VP6, and NSP4 genes showed resemblance to a G3P[3] canine strain identified in Italy in 1996. Dogs are a potential source of human viral pathogens.

  12. miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation

    Qiu, Weimin; Kassem, Moustapha

    2014-01-01

    Wnt signaling determines human stromal (mesenchymal) stem cell (hMSC) differentiation fate into the osteoblast or adipocyte lineage. microRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate many aspects of osteoblast biology. Thus, we examined miRNAs regulated by Wnt signaling...... in hMSC. We identified miRNA (miR)-141-3p as a Wnt target which in turn inhibited Wnt signaling. Moreover, miR-141-3p inhibited hMSC proliferation by arresting cells at the G1 phase of the cell cycle. miR-141-3p inhibited osteoblast differentiation of hMSC as evidenced by reduced alkaline phosphatase...... activity, gene expression and in vitro mineralized matrix formation. Bioinformatic studies, Western blot analysis and 3'UTR reporter assay demonstrated that cell division cycle 25A (CDC25A) is a direct target of miR-141-3p. siRNA-mediated knock-down of CDC25A inhibited hMSC proliferation and osteoblast...

  13. miR-200a-3p regulates TLR1 expression in bacterial challenged miiuy croaker.

    Wang, Yanjin; Xu, Guoliang; Han, Jingjing; Xu, Tianjun

    2016-10-01

    MicroRNAs (miRNAs) are highly conserved, small non-coding RNAs which post-transcriptionally regulate various biological processes by repressing mRNA translation or degradating mRNA. It has been demonstrated that miRNAs play crucial roles in regulating the immune system. In this study, we explored the potential roles of miR-200a-3p in regulating TLR signaling pathway in miiuy croaker. Bioinformatics analysis showed that miiuy croaker TLR1 (mmiTLR1) was a putative target of miR-200a-3p. Negative expression profiles in spleen of Vibrio anguillarum challenged miiuy croaker and in lipopolysaccharide (LPS) stimulated miiuy croaker leukocytes further validated the prediction. Luciferase reporter assays showed that the dual-luciferase reporter fused to the 3'UTR of wild type mmiTLR1 cotransfected with miR-200a-3p mimics exhibited a reduction in luciferase activity compared with the controls. All of the present data provide direct evidence that miR-200a-3p is involved in TLR1 expression modulation in miiuy croaker, which will offer a basis for better understanding of miRNA regulation in fish TLR signaling pathways. PMID:27288848

  14. Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21

    Christensen, Ulla; Møller-Larsen, Steffen; Nyegaard, Mette;

    2009-01-01

    Atopic dermatitis (AD) is a common, itchy skin disease of complex inheritance characterized by dermal and epidermal inflammation. The heritability is considerable and well documented. To date, four genome scans have examined the AD phenotype, showing replicated linkage at 3p26-22, 3q13-21 and 18q11...

  15. $\\beta$3p- spectroscopy and P-$\\gamma$ width determination in the decay of $^{31}$Ar

    We propose to perform a detailed study of the $\\beta$-decay of the dripline nucleus $^{31}$Ar. This will allow a detailed study of the $\\beta$-delayed 3p-decay as well as provide important information on the resonances of $^{30}$S and $^{29}$P, in particular the ratio between the P- and $\\gamma$- partial widths relevant for astrophysics.

  16. miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

    Mario Leonardo Squadrito

    2012-02-01

    Full Text Available Expression of the mannose receptor (MRC1/CD206 identifies macrophage subtypes, such as alternatively activated macrophages (AAMs and M2-polarized tumor-associated macrophages (TAMs, which are endowed with tissue-remodeling, proangiogenic, and protumoral activity. However, the significance of MRC1 expression for TAM's protumoral activity is unclear. Here, we describe and characterize miR-511-3p, an intronic microRNA (miRNA encoded by both mouse and human MRC1 genes. By using sensitive miRNA reporter vectors, we demonstrate robust expression and bioactivity of miR-511-3p in MRC1+ AAMs and TAMs. Unexpectedly, enforced expression of miR-511-3p tuned down the protumoral gene signature of MRC1+ TAMs and inhibited tumor growth. Our findings suggest that transcriptional activation of Mrc1 in TAMs evokes a genetic program orchestrated by miR-511-3p, which limits rather than enhances their protumoral functions. Besides uncovering a role for MRC1 as gatekeeper of TAM's protumoral genetic programs, these observations suggest that endogenous miRNAs may operate to establish thresholds for inflammatory cell activation in tumors.

  17. 3P2-3F2 pairing in dense neutron matter: the spectrum of solutions

    The 3P2-3F2 pairing model is generally considered to provide an adequate description of the superfluid states of neutron matter at densities some 2-3 times that of saturated symmetrical nuclear matter. The problem of solving the system of BCS gap equations expressing the 3P2-3F2 model is attacked with the aid of the separation approach. This method, developed originally for quantitative study of S-wave pairing in the presence of strong short-range repulsions, serves effectively to reduce the coupled, singular, nonlinear BCS integral equations to a set of coupled algebraic equations. For the first time, sufficient precision becomes accessible to resolve small energy splittings between the different pairing states. Adopting a perturbative strategy, we are able to identify and characterize the full repertoire of real solutions of the 3P2-3F2 pairing model, in the limiting regime of small tensor-coupling strength. The P-F channel coupling is seen to lift the striking parametric degeneracies revealed by a earlier separation treatment of the pure, uncoupled 3P2 pairing problem. Remarkably, incisive and robust results are obtained solely on the basis of analytic arguments. Unlike the traditional Ginzburg-Landau approach, the analysis is not restricted to the immediate vicinity of the critical temperature, but is equally reliable at zero temperature. Interesting connections and contrasts are drawn between triplet pairing in dense neutron matter and triplet pairing in liquid 3He

  18. Relativistic CI calculations of spectroscopic data for the 2p6 and 2p53l configurations in Ne-like ions between Mg III and Kr XXVII

    Energies, E1, M1, E2, M2 transition rates, oscillator strengths, and lifetimes from relativistic configuration interaction calculations are reported for the states of the 2p6, 2p53s, 2p53p, and 2p53d, configurations in all Ne-like ions between Mg III and Kr XXVII. Core–valence and core–core correlation effects are accounted for through single and double excitations to increasing sets of active orbitals. The Breit interaction and leading quantum electrodynamic effects are included as perturbations. The results are compared with experiments and other recent benchmark calculations. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%

  19. Relativistic CI calculations of spectroscopic data for the 2p6 and 2p53l configurations in Ne-like ions between Mg III and Kr XXVII

    Energies, E1, M1, E2, M2 transition rates, oscillator strengths, and lifetimes from relativistic configuration interaction calculations are reported for the states of the 2p6, 2p53s, 2p53p, and 2p53d, configurations in all Ne-like ions between Mg III and Kr XXVII. Core-valence and core-core correlation effects are accounted for through SD-expansions to increasing sets of active orbitals. The Breit interaction and leading QED effects are included as perturbations. The results are compared with experiments and other recent benchmark calculations. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%. (author)

  20. Lipid droplet proteins, Lds1p, Lds2p, and Rrt8p, are implicated in membrane protein transport associated with ergosterol.

    Ueno, Kazuma; Nagano, Makoto; Shimizu, Shigeki; Toshima, Junko Y; Toshima, Jiro

    2016-07-01

    Lipid droplets (LDs) are ubiquitous organelles, enclosed in a monolayer of phospholipid, which store excess fatty acids as neutral lipids such as triacylglycerol and sterol esters. Previous studies have revealed that LDs contain many proteins with various functions required for lipid metabolism and vesicular trafficking. Among them, Lds (Lipid Droplet in Sporulation) proteins, Lds1p and Lds2p, are reportedly induced and localized to LDs during yeast sporulation, but their cellular function has not been clarified. Here we show that the Lds proteins, Lds1p, Lds2p and Rrt8p, are expressed and localized at LDs in vegetative cells, being required for proper localization of plasma membrane proteins. We found that deletion of Lds genes led to mis-sorting of Wsc1p, a cell wall stress sensor, from the plasma membrane to the vacuole. We also demonstrated that lack of these proteins partially suppressed the growth defect and mis-sorting of the high-affinity tryptophan transporter Tat2p, induced by impairment of ergosterol biosynthesis. Furthermore, we identified Sec39p/Dsl3p, a component of the DSL1 tethering complex that mediates the interaction with COPI vesicles, as a binding partner for Lds2p. These results suggest a possible role of Lds proteins in maintenance of membrane lipid homeostasis and accompanying membrane protein transport. PMID:27216456

  1. Photoelectric characteristics of CH3NH3PbI3/p-Si heterojunction

    Yamei, Wu; Ruixia, Yang; Hanmin, Tian; Shuai, Chen

    2016-05-01

    Organic–inorganic hybrid perovskite CH3NH3PbI3 film is prepared on p-type silicon substrate using the one-step solution method to form a CH3NH3PbI3/p-Si heterojunction. The film morphology and structure are characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The photoelectric properties of the CH3NH3PbI3/p-Si heterojunction are studied by testing the current–voltage (I–V) with and without illumination and capacitance–voltage (C–V) characteristics. It turns out from the I–V curve without illumination that the CH3NH3PbI3/p-Si heterojunction has a rectifier feature with the rectification ratio over 70 at the bias of ±5 V. Also, there appears a photoelectric conversion phenomenon on this heterojunction with a short circuit current (Isc) of 0.16 μA and an open circuit voltage (Voc) of about 10 mV The high frequency C–V characteristic of the Ag/CH3NH3PbI3/p-Si heterojunction turns out to be similar to that of the metal–insulator–semiconductor (MIS) structure, and a parallel translation of the C–V curve along the forward voltage axis is found. This parallel translation means the existence of defects at the CH3NH3PbI3/p-Si interface and positive fixed charges in the CH3NH3PbI3 layer. The defects at the interface of the CH3NH3PbI3/p-Si heterojunction result in the dramatic decline of the Voc. Besides, the C–V test of CH3NH3PbI3 film shows a non-linear dielectric property and the dielectric value is about 4.64 as calculated. Project supported by the Hebei Province Natural Science Foundation of China (No. F2014202184) and the Tianjin Natural Science Foundation of China (No. 15JCZDJC37800).

  2. An extremal problem on potentially $K_{p_{1},p_{2},...,p_{t}}$-graphic sequences

    Lai, Chunhui

    2004-01-01

    A sequence $S$ is potentially $K_{p_{1},p_{2},...,p_{t}}$ graphical if it has a realization containing a $K_{p_{1},p_{2},...,p_{t}}$ as a subgraph, where $K_{p_{1},p_{2},...,p_{t}}$ is a complete t-partite graph with partition sizes $p_{1},p_{2},...,p_{t} (p_{1}\\geq p_{2}\\geq ...\\geq p_{t} \\geq 1)$. Let $\\sigma(K_{p_{1},p_{2},...,p_{t}}, n)$ denote the smallest degree sum such that every $n$-term graphical sequence $S$ with $\\sigma(S)\\geq \\sigma(K_{p_{1},p_{2},...,p_{t}}, n)$ is potentially $...

  3. Two isotypic diphosphates Li M2H 3(P 2O 7) 2 ( M=Ni, Co) containing ferromagnetic zigzag MO 6 chains

    Yang, Tao; Yang, Sihai; Liao, Fuhui; Lin, Jianhua

    2008-06-01

    Two new isotypic phosphates LiNi 2H 3(P 2O 7) 2 ( 1) and LiCo 2H 3(P 2O 7) 2 ( 2) have been hydrothermally synthesized and structurally characterized by the single-crystal X-ray diffraction technique. They crystallize in the monoclinic space group C2/ c with the lattice: a=10.925(2) Å, b=12.774(3) Å, c=8.8833(18) Å, β=123.20(3)° for 1 and a=10.999(2) Å, b=12.863(3) Å, c=8.9419(18) Å, β=123.00(3)° for 2. The transition metal atoms are octahedrally coordinated, whereas the lithium and phosphorus atoms are all tetrahedrally coordinated. As the lithium-induced derivatives of MH 2P 2O 7 ( M=Ni, Co), 1 and 2 possess the same structure with MH 2P 2O 7 in terms of topology, comprising the MO 6 zigzag chains and P 2O 7 as the interchain groups. The magnetisms of 1 and 2 could be interpreted by adopting a quasi-one-dimensional (1D) zigzag chain model as that in their parent compounds: both 1 and 2 have ferromagnetic (FM) NiO 6/CoO 6 chains; 1 shows a FM cluster glass behavior at low temperatures, which is originated from the possible antiferromagnetic (AFM) next-nearest-neighbour intrachain interactions; 2 shows a AFM ordering at TN=2.6 K and a metamagnetic transition at HC=4.2 kOe at 1.8 K.

  4. Gamma-ray irradiation induced bulk photochromism in WO3-P2O5 glass

    Shen, Wei; Baccaro, Stefania; Cemmi, Alessia; Xu, Xiaoqing; Chen, Guorong

    2015-11-01

    In the present work, photochromism of WO3-P2O5 glass under gamma-ray irradiation was reported. As-prepared glass samples with different WO3 content are all optically transparent in the visible wavelength range thanks to the addition of a small amount of oxidizing couple Sb2O3-NaNO3. The photochromic properties are identified by transmission spectra of the glasses before and after irradiation. The results show that the irradiation induced darkening results from the reduction of W6+ to W5+ or W4+. The existence of WO6 clusters in glasses of high WO3 content is proved by XPS, which is the main reason for the obvious photochromic effects. The WO3-P2O5 glass is a promising candidate in gamma-ray sensitive detector.

  5. Parallel 3D Finite Element Particle-in-Cell Simulations with Pic3P

    Candel, A.; Kabel, A.; Lee, L.; Li, Z.; Ng, C.; Schussman, G.; Ko, K.; /SLAC; Ben-Zvi, I.; Kewisch, J.; /Brookhaven

    2009-06-19

    SLAC's Advanced Computations Department (ACD) has developed the parallel 3D Finite Element electromagnetic Particle-In-Cell code Pic3P. Designed for simulations of beam-cavity interactions dominated by space charge effects, Pic3P solves the complete set of Maxwell-Lorentz equations self-consistently and includes space-charge, retardation and boundary effects from first principles. Higher-order Finite Element methods with adaptive refinement on conformal unstructured meshes lead to highly efficient use of computational resources. Massively parallel processing with dynamic load balancing enables large-scale modeling of photoinjectors with unprecedented accuracy, aiding the design and operation of next-generation accelerator facilities. Applications include the LCLS RF gun and the BNL polarized SRF gun.

  6. Redox mechanism in the binary transition metal phosphide Cu3P

    Mauvernay, B.; Doublet, M.-L.; Monconduit, L.

    2006-05-01

    The electrochemical behaviour of the binary transition metal phosphide Cu3P towards lithium is investigated through galvano- and potentiostatic measurements. Obtained through high-temperature synthesis, this system shows a better volumetric capacity than graphite and a good capacity retention. In situ X-ray diffraction and first-principles electronic structure calculations are combined with the electrochemical results to show that the complete insertion of 3Li+ in the Cu3P electrode proceeds with the formation of three intermediate phases of lithium composition LixCu(3-x)P (x=1,2,3). The extra capacity previously observed in discharge is now clearly assigned to lithium insertion into the CuP2 impurity and to SEI reactions.

  7. Research of using mobile agents for information discovery in P2P networks

    The technology of P2P is a new network-computing model that has great value of commerce and technology. After analyzing the current information discovery technology in P2P network, a new solution that is based on mobile agent is proposed. The mobile agent solution can reduce the need of bandwidth, be adapt to the dynamic of P2P network, and be asynchronous and be very fault tolerant. (authors)

  8. Analysis and Design of Instant Message System Based on P2P

    Shen Zhiwei; Ma Shaowu

    2008-01-01

    By analyzing current development conditions of mainstream Instant Message technologies and services, some detailed discussion about technical solution and formal operation deployment strategies of P2P Instant Message Services based on Interact is made. Several crucial problems of P2P Instant Message System about services management, interconnection with other instant message, security and profit-making mode are analyzed,, and how to develop P2P IM Services is proposed.

  9. IPTV-RM: A Resources Monitoring Architecture for P2P IPTV Systems

    Wenxian Wang; Xingshu Chen; Haizhou Wang

    2012-01-01

    Resources monitoring is an important problem of the overall efficient usage and control of P2P IPTV systems. The resources of IPTV can include all distributing servers, programs and peers. Several researches have tried to address this issue, but most of them illuminated P2P traffic characterization, identification and user behavior. The main contributions of this paper are twofold. Firstly, a resources monitoring architecture for P2P IPTV systems, IPTV-RM, was presented based on previous work...

  10. Convergence of Internet and TV: The Commercial Viability of P2P Content Delivery

    De Boever, Jorn

    2009-01-01

    The popularity of (illegal) P2P (peer-to-peer) file sharing has a disruptive impact on Internet traffic and business models of content providers. In addition, several studies have found an increasing demand for bandwidth consuming content, such as video, on the Internet. Although P2P systems have been put forward as a scalable and inexpensive model to deliver such content, there has been relatively little economic analysis of the potentials and obstacles of P2P systems as a ...

  11. In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.

    Muhammad Saeed

    Full Text Available The retinoblastoma protein (pRb and the related proteins Rb2/p130 and 107 represent the "pocket protein" family of cell cycle regulators. A key function of these proteins is the cell cycle dependent modulation of E2F-regulated genes. The biological activity of these proteins is controlled by acetylation and phosphorylation in a cell cycle dependent manner. In this study we attempted to investigate the interdependence of acetylation and phosphorylation of Rb2/p130 in vitro. After having identified the acetyltransferase p300 among several acetyltransferases to be associated with Rb2/p130 during S-phase in NIH3T3 cells in vivo, we used this enzyme and the CDK4 protein kinase for in vitro modification of a variety of full length Rb2/p130 and truncated versions with mutations in the acetylatable lysine residues 1079, 128 and 130. Mutation of these residues results in the complete loss of Rb2/p130 acetylation. Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced. Preacetylation of Rb2/p130 strongly enhances CDK4-catalyzed phosphorylation, whereas deacetylation completely abolishes in vitro phosphorylation. In contrast, phosphorylation completely inhibits acetylation of Rb2/p130 by p300. These results suggest a mutual interdependence of modifications in a way that acetylation primes Rb2/p130 for phosphorylation and only dephosphorylated Rb2/p130 can be subject to acetylation. Human papillomavirus 16-E7 protein, which increases acetylation of Rb2/p130 by p300 strongly reduces phosphorylation of this protein by CDK4. This suggests that the balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control.

  12. Building Database Coordination in p2p Systems Using Eca Rules

    Roshelova, Albena

    2004-01-01

    Recently, data integration systems and peer database management systems that attempt to model and integrate data in a peer-to-peer (p2p) environment have attracted the attention of researchers. Such systems give opportunities to the local relational database management system to exchange data with other nodes in a p2p environment. The databases systems in p2p are completely autonomous, heterogeneous and independent, each maintaining its own data. We would like to use these databases to answer...

  13. Implementing a Secure Key Issuing Scheme for Communication in P2P Networks

    Mohammed Azharuddin; Annapurna P Patil

    2012-01-01

    Key issuing scheme focuses on the confidentiality maintained in using the secret key for communicationin p2p networks. Identity based cryptography (IBC) was introduced into peer-to-peer (P2P) networks recently for identity verification and authentication purposes. However, current IBC-based solutions were not addressing the problem of secure private key issuing. In this paper we propose a novel secure key issuing scheme for P2P networks using IBC. We present an IBC infrastructure setup phase...

  14. Ca3P2 and other topological semimetals with line nodes and drumhead surface states

    Chan, Y.-H.; Chiu, Ching-Kai; Chou, M. Y.; Schnyder, Andreas P.

    2016-05-01

    As opposed to ordinary metals, whose Fermi surfaces are two dimensional, topological (semi)metals can exhibit protected one-dimensional Fermi lines or zero-dimensional Fermi points, which arise due to an intricate interplay between symmetry and topology of the electronic wave functions. Here, we study how reflection symmetry, time-reversal symmetry, SU(2) spin-rotation symmetry, and inversion symmetry lead to the topological protection of line nodes in three-dimensional semimetals. We obtain the crystalline invariants that guarantee the stability of the line nodes in the bulk and show that a quantized Berry phase leads to the appearance of protected surfaces states, which take the shape of a drumhead. By deriving a relation between the crystalline invariants and the Berry phase, we establish a direct connection between the stability of the line nodes and the drumhead surface states. Furthermore, we show that the dispersion minimum of the drumhead state leads to a Van Hove singularity in the surface density of states, which can serve as an experimental fingerprint of the topological surface state. As a representative example of a topological semimetal, we consider Ca3P2 , which has a line of Dirac nodes near the Fermi energy. The topological properties of Ca3P2 are discussed in terms of a low-energy effective theory and a tight-binding model, derived from ab initio DFT calculations. Our microscopic model for Ca3P2 shows that the drumhead surface states have a rather weak dispersion, which implies that correlation effects are enhanced at the surface of Ca3P2 .

  15. Temperature dependence and mechanism of the reaction between O(3P) and chlorine dioxide

    Colussi, A. J.; Sander, S. P.; Fiedl, R. R.

    1992-01-01

    Second-order rate constants for the decay of O(3P) in excess chlorine dioxide, k(II), were measured as a function of total pressure (20-600 Torr argon) and temperature (248-312 K), using flash photolysis-atomic resonance fluorescence. Results indicate that k(II) is pressure dependent with a value, K(b), that is nonzero at zero pressure, and both the third-order rate constant and k(b) have negative temperature dependences.

  16. The Participative Design of an Endoscopy Facility using Lean 3P.

    Smith, Iain

    2016-01-01

    In the UK, bowel cancer is the second largest cancer killer. Diagnosing people earlier can save lives but demand for endoscopies is increasing and this can put pressure on waiting times. To address this challenge, an endoscopy unit in North East England decided to improve their facilities to increase capacity and create environments that improve the experience of users. This presented a significant opportunity for step change improvement but also a problem in terms of creating designs that meet user requirements whilst addressing structural or space constraints. The Lean design process known as '3P' (standing for the production preparation process) was utilised as a participative design strategy to engage stakeholders in the design of the new department. This involved a time-out workshop (or 3P event) in which Lean and participative design tools were utilised to create an innovative design based on 'point of delivery' (POD) principles. The team created a design that demonstrated an increase in treatment room capacity by 25% and bed capacity by 70% whilst reducing travel distance for patients by 25.8% and staff by 27.1%. This was achieved with an increase in available space of only 13%. The Lean 3P method provided a structured approach for corporate and clinical staff to work together with patient representatives as cross-functional teams. This participative approach facilitated communication and learning between stakeholders about care processes and personal preferences. Lean 3P therefore appears to be a promising approach to improving the healthcare facilities design process to meet user requirements. PMID:27493744

  17. Omega3P: A Parallel Finite-Element Eigenmode Analysis Code for Accelerator Cavities

    Lee, Lie-Quan; Li, Zenghai; Ng, Cho; Ko, Kwok; /SLAC

    2009-03-04

    Omega3P is a parallel eigenmode calculation code for accelerator cavities in frequency domain analysis using finite-element methods. In this report, we will present detailed finite-element formulations and resulting eigenvalue problems for lossless cavities, cavities with lossy materials, cavities with imperfectly conducting surfaces, and cavities with waveguide coupling. We will discuss the parallel algorithms for solving those eigenvalue problems and demonstrate modeling of accelerator cavities through different examples.

  18. An Optimized and Improved Network Trust Model Based on P2P

    Li Wei

    2013-10-01

    Full Text Available Because of the spring up of the P2P network application, its open, anonymous and self-organized characteristics has offered a path for the spreading of virus and junk data, and the security has aroused people’s common concern. The traditional network trust model dealt with dishonest node has certain limitation, for this, improved P2P network trust model and applied D-S evidence theory to the trusted computing of trust model. Through simulation experiment, the result showed: the improved P2P network trust model efficiently increased the successful trading rate of P2P network and improved the network environment

  19. Suppression of Zeeman Relaxation in Cold Collisions of \\(^2P_{1/2}\\) Atoms

    Tscherbul, T.V.; Buchachenko, A. A.; Dalgarno, Alexander; Lu, M.-J.; Weinstein, J. D.

    2009-01-01

    We present a combined experimental and theoretical study of angular momentum depolarization in cold collisions of \\(^2P\\) atoms in the presence of an external magnetic field. We show that collision-induced Zeeman relaxation of Ga\\(^2P_{1/2}\\) and In \\(^2P_{1/2}\\) atoms in cold \\(^4\\)He gas is dramatically suppressed compared to atoms in \\(^2P_{3/2}\\) states. Using rigorous quantum-scattering calculations based on ab initio interaction potentials, we demonstrate that Zeeman transitions in coll...

  20. Sla2p Is Associated with the Yeast Cortical Actin Cytoskeleton via Redundant Localization Signals

    Yang, Shirley; Cope, M. Jamie T.V.; Drubin, David G.

    1999-01-01

    Sla2p, also known as End4p and Mop2p, is the founding member of a widely conserved family of actin-binding proteins, a distinguishing feature of which is a C-terminal region homologous to the C terminus of talin. These proteins may function in actin cytoskeleton-mediated plasma membrane remodeling. A human homologue of Sla2p binds to huntingtin, the protein whose mutation results in Huntington’s disease. Here we establish by immunolocalization that Sla2p is a component of the yeast cortical a...

  1. What Happened to P2P Systems? A Special Focus on Content Distribution Systems

    Mohammad Fawzi, Ali

    2008-01-01

    Peer-to-Peer (P2P) technology has emerged as a new distributed computing paradigm. P2P technology attempts to "harness the powers of the edges of the Internet" by making efficient and effective use of peers (users) at the "edge" of the Internet, by direct interaction between peers of the system. P2P architecture has witnessed lots of interest and research in the latest years because of the popularity of file-sharing applications based on it. Content distribution is an essential P2P applicati...

  2. Resonant inverse photoemission study of late transition metals at 3p absorption edge

    Full text: Resonant inverse photoemission spectra (RIPES) of late transition metals (TM) were observed near TM 3p absorption edge. The RIPES spectra of polycrystalline Co, Ni and Cu, as well as single crystal Ni, were observed. Figure 1 shows resonant IPES spectra of polycrystalline Co, Ni and Cu, which were prepared by evaporation. These spectra ware excited by energy above 3p absorption edge (off-resonance). Since a core hole is created by these energies, TM 3d → 3p fluorescence peak is observed in each spectrum at high energy, which is indicated by vertical bars. The main peak just above EF is TM 3d structure, while TM 4sp is observed at 10 ∼ 15 eV. In resonant spectra, the 3d structure changes its intensity, while the 4sp structure does not. In case of Ni metal, satellite structures are also observed at about 2 and 4 eV. From a calculation by Tanaka and Jo, which is based on the Anderson impurity model, the observation of satellite structures suggests the 10 ∼ 20 % 3d8 in ground state The RIPES spectra in this study give us a direct evidence of 3d8 component in Ni metal

  3. $^3P_2$-$^3F_2$ Pairing in Dense Neutron Matter The Spectrum of Solutions

    Zverev, M V; Khodel, V A

    2003-01-01

    The $^3P_2$-$^3F_2$ pairing model is generally considered to provide an adequate description of the superfluid states of neutron matter at densities some 2-3 times that of saturated symmetrical nuclear matter. The problem of solving the system of BCS gap equations expressing the $^3P_2$-$^3F_2$ model is attacked with the aid of the separation approach. This method, developed originally for quantitative study of S-wave pairing in the presence of strong short-range repulsions, serves effectively to reduce the coupled, singular, nonlinear BCS integral equations to a set of coupled algebraic equations. For the first time, sufficient precision becomes accessible to resolve small energy splittings between the different pairing states. Adopting a perturbative strategy, we are able to identify and characterize the full repertoire of real solutions of the $^3P_2$-$^3F_2$ pairing model, in the limiting regime of small tensor-coupling strength. The P-F channel coupling is seen to lift the striking parametric degeneracie...

  4. Study of the Ne(^3P_2) + CH_3F Electron Transfer Reaction below 1 Kelvin

    Jankunas, Justin; Osterwalder, Andreas

    2014-01-01

    Relatively little is known about the dynamics of electron transfer reactions at low collision energy. We present a study of Penning ionization of ground state methyl fluoride molecules by electronically excited neon atoms in the 13 $\\mu$eV--4.8 meV (150 mK--56 K) collision energy range, using a neutral-neutral merged beam setup. Relative cross sections have been measured for three Ne($^3P_2$)+ CH$_3$F reaction channels by counting the number of CH$_3$F$^+$, CH$_2$F$^+$, and CH$_3^+$ product ions, as a function of relative velocity between the neon and methyl fluoride molecular beams. Experimental cross sections markedly deviate from the Langevin capture model at collision energies above 20 K. The branching ratios are constant. In other words, the chemical shape of the CH$_3$F molecule, as seen by Ne($^3P_2$) atom, appears not to change as the collision energy is varied, in contrast to related Ne($^3P_J$) + CH$_3$X (X=Cl and Br) reactions at higher collision energies.

  5. Phase transitions in Cd3P2 at high pressures and high temperatures

    Yel'kin, F.S.; Sidorov, V.A.; Waskowska, A.;

    2008-01-01

    The high-pressure, high-temperature structural behaviour of Cd3P2 has been studied using electrical resistance measurements, differential thermal analysis, thermo baric analysis and X-ray diffraction. At room temperature, a phase transformation is observed at 4.0 GPa in compression. The experimen......The high-pressure, high-temperature structural behaviour of Cd3P2 has been studied using electrical resistance measurements, differential thermal analysis, thermo baric analysis and X-ray diffraction. At room temperature, a phase transformation is observed at 4.0 GPa in compression....... The experimental zero-pressure bulk modulus of the low-pressure phase is 64.7(7) GPa, which agrees quite well with the calculated value of 66.3 GPa using the tight-binding linear muffin-tin orbital method within the local density approximation. Tentatively, the high-pressure phase has an orthorhombic crystal...... structure with space group Pmmn (#59). The relative volume change at the phase transition is Delta V/V= -5.5%. Amorphization of the sample occurs above 25 GPa. A P-T phase diagram of Cd3P2 has been constructed. A metastable phase is observed at ambient conditions after heating the sample to above 600 K...

  6. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    Friebe, Jan; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several other optical transitions from $^1S_0$ to the $^3P_J$-level system for $^{24}$Mg, $^{25}$Mg and $^{26}$Mg. We describe in detail the components of our optical frequency standard like the stabilized spectroscopy laser, the atomic beam apparatus used for Ramsey-Bord\\'e interferometry and the frequency comb generator and discuss the uncertainty contributions to our measurement including the first and second order Doppler effect. An upper limit of $3\\times10^{-13}$ in one second for the short term instability of our optical f...

  7. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway

    Zhao, Liang; Zhang, Yubao, E-mail: zhyb880077@sina.com

    2015-02-13

    Recent research indicates that non-coding microRNAs (miRNAs) help regulate basic cellular processes in many types of cancer cells. We hypothesized that overexpression of miR-342-3p might affect proliferation of hepatocellular carcinoma (HCC) cells. After confirming overexpression of miR-342-3p with qRT-PCR, MTT assay showed that HCC cell proliferation was significantly inhibited by miR-342-3p, and that it significantly decreased BrdU-positive cell proliferation by nearly sixfold. Searching for targets using three algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes. Results of western blot on extracted nuclear proteins of HepG2 and HCT-116 cells showed that miR-342-3p reduced and miR-342-3p-in increased p65 nuclear levels and qRT-PCR found that NF-κB pathway downstream genes were downregulated by miR-342-3p and upregulated by miR-342-3p-in, confirming that miR-342 targets NF-κB pathway. Overexpression of Ikk-γ, TAB2 and TAB3 partially rescued HCC cells proliferation inhibited by miR-342-3p. Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples. Our results show that miR-342-3p has a significant role in HCC cell proliferation and is suitable for investigation of therapeutic targets. - Highlights: • MiR-342-3p suppresses hepatocellular carcinoma cell proliferation. • MiR-342-3p targets IKK-γ, TAB2 and TAB3 genes. • MiR-342-3p downregulates NF-kB signaling pathway. • MiR-342-3p is downregulated in clinical hepatocellular carcinoma samples. • The expression of miR-342-3p and its target gene is inversely related.

  8. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway

    Recent research indicates that non-coding microRNAs (miRNAs) help regulate basic cellular processes in many types of cancer cells. We hypothesized that overexpression of miR-342-3p might affect proliferation of hepatocellular carcinoma (HCC) cells. After confirming overexpression of miR-342-3p with qRT-PCR, MTT assay showed that HCC cell proliferation was significantly inhibited by miR-342-3p, and that it significantly decreased BrdU-positive cell proliferation by nearly sixfold. Searching for targets using three algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes. Results of western blot on extracted nuclear proteins of HepG2 and HCT-116 cells showed that miR-342-3p reduced and miR-342-3p-in increased p65 nuclear levels and qRT-PCR found that NF-κB pathway downstream genes were downregulated by miR-342-3p and upregulated by miR-342-3p-in, confirming that miR-342 targets NF-κB pathway. Overexpression of Ikk-γ, TAB2 and TAB3 partially rescued HCC cells proliferation inhibited by miR-342-3p. Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples. Our results show that miR-342-3p has a significant role in HCC cell proliferation and is suitable for investigation of therapeutic targets. - Highlights: • MiR-342-3p suppresses hepatocellular carcinoma cell proliferation. • MiR-342-3p targets IKK-γ, TAB2 and TAB3 genes. • MiR-342-3p downregulates NF-kB signaling pathway. • MiR-342-3p is downregulated in clinical hepatocellular carcinoma samples. • The expression of miR-342-3p and its target gene is inversely related

  9. TCLM-P2P: Task Collaboration Logic Model Oriented to P2P Community%TCLM-P2P:面向P2P社区的任务协作逻辑模型

    王杨; 王汝传; 严远亭; 韩志杰; 赵保华

    2012-01-01

    P2P网络中广泛存在的“free riding”现象使其在任务协作领域的应用受到了极大制约.为了实现P2P网络环境下的有效任务协作,提出了一种具有激励机制的任务协作逻辑模型.基于Agent理论,首先给出了对等体、半对等体、P2P社区等概念;然后在合同网的框架下提出了面向P2P网络社区的任务协作逻辑模型TCLM-P2P(task collaborative logic model oriented to P2P community).相对于传统的任务协作模型,在合理的前提假设条件下,模型给出了模型公理和协作规则.该模型通过基于虚拟积分的协作算法实现了具有激励机制的P2P网络中的任务分配与协作.原型系统的实现及仿真实验结果表明TCLM-P2P模型具有可行性和有效性:不仅能够激励自利节点主动参与到任务分配与协作中;同时也能在一定程度上抑制节点的free riding行为,从而保障了P2P系统的有序工作.%Traditional P2P networks mainly are applied to file sharing and instant message fields. However, how to perform the task collaboration based on P2P community is a challenging job. The former research work indicated that the task collaboration in P2P network had been greatly restricted by free riding behaviors. To realize effective task allocating and task collaborating in P2P network environment, this paper presents a task collaboration logic model oriented to P2P community. Based on agent and multi-agent theory, the paper firstly introduces some concepts including the peer body, half-peer body and P2P community; then the TCLM-P2P is presented including some collaboration axioms and rulers. In order to enhance the incentive mechanism, virtual score becomes the main goal which each peer endeavor pursues. In addition, based on the contract net protocol, a task collaboration algorithm is presented. The proposed algorithm is composed of two phases. One is the task collaboration and the other is the task second bid when some peers fail

  10. Molecular cloning of t(2;7)(p24.3;p14.2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia.

    Fujita, Kazuhiro; Sanada, Masashi; Harada, Hiroshi; Mori, Hiraku; Niikura, Haruo; Omine, Mitsuhiro; Inazawa, Johji; Imoto, Issei

    2009-06-01

    In this study, we report the molecular structure of the breakpoint region in a new chromosomal translocation, t(2;7)(p24.3;p14.2), in a case of acute myeloid leukemia transformed from myelodysplastic syndrome (MDS). An extensive fluorescence in situ hybridization (FISH) analysis showed that NAG (2p24.3) and ELMO1 (7p14.2) were involved at the breakpoints of t(2;7)(p24.3;p14.2). Furthermore, we detected a novel chimeric transcript consisting of NAG and ELMO1. Interestingly, this transcript encoded a truncated molecular form of 3'ELMO1 as the result of a frameshift caused by the chromosomal translocation. Although this study does not provide direct evidence that a defect in NAG-ELMO1 plays a role in the pathogenesis or the leukemic change in MDS, it does suggest that defects in NAG-ELMO1 potentially contributed to the leukemic progression in this case. PMID:19407829

  11. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

    Zhai, Qingna [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China); Zhou, Liang [Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Guangdong (China); Zhao, Chunjuan [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China); Wan, Jun [Section of Biochemistry and Cell Biology, Division of Life Science, The Hong Kong University of Science and Technology (Hong Kong); Yu, Zhendong, E-mail: zhendongyu66@hotmail.com [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Guo, Xin; Qin, Jie; Chen, Jing [Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Guangdong (China); Lu, Ruijing [Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong (China); Shantou University Medical College, Guangdong (China)

    2012-03-23

    Highlights: Black-Right-Pointing-Pointer Previous method was the second-generation sequencing technology. Black-Right-Pointing-Pointer miR-508-3p and miR-509-3p were significantly down-regulated in RCC tissues. Black-Right-Pointing-Pointer They can inhibit cell proliferation and migration and promote cell apoptosis. Black-Right-Pointing-Pointer The expression of miR-508-3p was significantly decreased in RCC patients plasma. Black-Right-Pointing-Pointer miR-508-3p may be a novel diagnostic marker of RCC. -- Abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.

  12. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

    Highlights: ► Previous method was the second-generation sequencing technology. ► miR-508-3p and miR-509-3p were significantly down-regulated in RCC tissues. ► They can inhibit cell proliferation and migration and promote cell apoptosis. ► The expression of miR-508-3p was significantly decreased in RCC patients plasma. ► miR-508-3p may be a novel diagnostic marker of RCC. -- Abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.

  13. Deactivation of Ni2P/SiO2 catalyst in hydrodechlorination of chlorobenzene

    Highlights: • Ni2P/SiO2 has higher performance than Ni/SiO2 for hydrodechlorination. • Ni2P has higher resistance to HCl poison and to sintering than Ni. • Ni2P/SiO2 deactivation is mainly attributed to carbonaceous deposit. • Ni/SiO2 deactivation is mostly due to HCl poison and Ni sintering. - Abstract: The deactivation of the Ni2P/SiO2 catalyst in the hydrodechlorination of chlorobenzene was studied. To better illuminate the reasons for the deactivation, the effect of HCl on the structure and activity of Ni2P/SiO2 was investigated. For comparison, the deactivation of the Ni/SiO2 catalyst was also involved. It was found that the Ni2P particles possessed good resistance to HCl poison and to sintering, which is ascribed to the electron-deficiency of Niδ+(0 < δ < 1) site in Ni2P. Acted as the Lewis and Brönsted acid site, the Niδ+ site and the P-OH group on Ni2P/SiO2 catalyzed the formation of the carbonaceous deposit that was difficultly eliminated by hydrogenation. The carbonaceous deposit covered the active sites and might also induce a decrease in the Ni2P crystallinity, subsequently leading to the Ni2P/SiO2 deactivation. Different from Ni2P/SiO2, Ni/SiO2 was mainly deactivated by the chlorine poison and the sintering of nickel crystallites

  14. Institute of Information Network Technology%P2P-SIP融合及P2P-SIP系统设计

    吴亮

    2010-01-01

    随着现代通信技术的不断发展,P2P(对等网络)技术与SIP(会话初始化协议)之间相互融合成为当前研究的一个热点.文章首先介绍了P2P技术和SIP协议,随后研究怎样将P2P架构与SIP系统进行融合,重点讨论了P2P-SIP的实现过程,包括P2P-SIP终端如何使用SIP协议携带P2P消息实现节点的发现、加入、离开和用户注册等过程.

  15. 基于 SIP 的 P2P VoIP技术研究%Research on P2 P VoIP Technology Based on SIP

    杜经纬

    2015-01-01

    随着三网融合的推进,将会给VoIP带来广阔的发展空间。针对目前常用的VoIP系统存在的网络开销高、呼叫接通率低、信令过于复杂等问题,在对SIP协议在P2P网络环境下实现VoIP的关键技术进行认真分析的基础上,提出了基于SIP的P2P VoIP。通过给出基于SIP的P2P VoIP的基本体系结构,分析了该系统中对等点的发现、用户注册及离线、呼叫建立等功能的实现方法,最后提出了基于SIP的P2P VoIP系统还应该考虑的一些问题。%With the progress in the convergence of the telecommunication, internet and broadcasting networks, VoIP will be presented with broad space for development.However, existing VoIP systems usually suffer from high network overhead, low call completing rate, complex signaling, etc.To solve these problems, this paper, based on a thorough analysis of key technologists involved in VoIP using SIP protocol in the P2P network scenario, proposed the SIP-based P2P VoIP system.By introducing the basic architecture of the SIP-based P2P VoIP system, this paper also analyzes the implementation of functions including peer discovery, user registration and getting offline and call establishment, and points out some questions that should be considered in this system.

  16. Theoretical study of intramultiplet transitions in collisions of atoms in 3P electronic states with structureless targets: Ca(3P)+He

    The quantum close-coupling (CC) treatment of collisions of an atom in a 3P electronic state with a structureless target is developed, based on earlier work of Mies [Phys. Rev. A 7, 942 (1973)], and a j/sub z/-conserving [coupled-states (CS)] simplification presented. There is no direct coupling between the J = 0 and J = 1 levels; transitions between these levels will occur only as a result of Coriolis coupling involving the J = 2 state. Actual CC and CS calculations are reported for collisions of Ca 43P/sup o/ with He, based on the potential curves of Malvern [J. Phys. B 11, 831 (1978)]. In the CC results, of the three independent cross sections, J = 2→1 is predicted to be largest, and J = 2→0 smallest, over the entire range of collision energies sampled. By contrast, the CS approximation predicts the 1→0 transition to be forbidden, and yields only fair accuracy for the CC 2→1 and 2→0 transitions. The coupling between spin-orbit states is also interpreted within an adiabatic model. A comparison with the experimental results of Yuh and Dagdigian (preceding paper) is made by averaging the CC cross sections over the experimental translational energy distribution. The experimental cross sections for the 2→1 and 2→0 transitions are 3--4 times larger than the theoretical values, and the 2→0 cross section is found experimentally to be approx.3 times larger than the 1→0 cross section, in direct contrast with the theoretical prediction for this ratio

  17. Protein Kinase A Is Central for Forward Transport of Two-pore Domain Potassium Channels K2P3.1 and K2P9.1*

    Mant, Alexandra; Elliott, David; Eyers, Patrick A.; O'Kelly, Ita M.

    2011-01-01

    Acid-sensitive two-pore domain potassium channels (K2P3.1 and K2P9.1) play key roles in both physiological and pathophysiological mechanisms, the most fundamental of which is control of resting membrane potential of cells in which they are expressed. These background “leak” channels are constitutively active once expressed at the plasma membrane, and hence tight control of their targeting and surface expression is fundamental to the regulation of K+ flux and cell excitability. The chaperone p...

  18. Phagocytes: A Holistic Defense and Protection Against Active P2P Worms

    Chen, Ruichuan; Crowcroft, Jon; Tang, Liyong; Chen, Zhong

    2011-01-01

    Active Peer-to-Peer (P2P) worms present serious threats to the global Internet by exploiting popular P2P applications to perform rapid topological self-propagation. Active P2P worms pose more deadly threats than normal scanning worms because they do not exhibit easily detectable anomalies, thus many existing defenses are no longer effective. We propose an immunity system with Phagocytes --- a small subset of elected P2P hosts that are immune with high probability and specialized in finding and "eating" worms in the P2P overlay. The Phagocytes will monitor their managed P2P hosts' connection patterns and traffic volume in an attempt to detect active P2P worm attacks. Once detected, local isolation, alert propagation and software patching will take place for containment. The Phagocytes further provide the access control and filtering mechanisms for communication establishment between the internal P2P overlay and the external hosts. We design a novel adaptive and interaction-based computational puzzle scheme at ...

  19. A Study of Perkins 2P1 Graduation Performance Rates at Virginia Western Community College

    Archer, J. Andrew.

    2006-01-01

    "2P1" is the Carl Perkins label for an institution's graduation performance rate. Systems receiving Perkins funds, like Virginia's 23 community colleges, are expected to meet a federally approved 2P1 target rate. For the 3-year period 1999-2001 Virginia Western Community College (VWCC) was one of seven community colleges in the VCCS (Virginia…

  20. The full 2p-h TDA and other self-energy approximants

    A super-operator formulation for decoupling symmetry blocks of the full 2p-h TDA electron propagator matric is presented; accuracy is explored using the full 2p-h TDA overlap amplitudes to calculate relative ionization intensities for N2 and H2O. The effect of excluding orbitals on IPs and relative ionization cross sections is reported. (orig.)

  1. HFBP: Identifying P2P Traffic by Host Level and Flow Level Behavior Profiles

    Jinghua Yan

    2013-08-01

    Full Text Available Recently, Peer-to-peer (P2P networks have been widely applied in streaming media, instant messaging, file sharing and other fields, which have occupied more and more network bandwidth. Accurately identify P2P traffic is very important to management and control P2P traffic. In this paper, we introduce HFBP, a novel P2P identification scheme based on the host level and flow level behavior profiles of P2P traffic. HFBP consists of two stages. In the first stage, we calculate the probability that a host takes part in P2P application by matching its behavior with some host level behavior rules. In the second stage, we compute the probability that a flow belonging to P2P application by comparing the statistical features of each flow in the host with several flow feature profiles. We evaluate HFBP using real traffic traces. The identification accuracy achieves 93.1% and 95.1% in terms of flow and byte respectively. The experimental results prove that HFBP obtains satisfactory performance in identifying P2P traffic. 

  2. Pseudogene CYP4Z2P 3′UTR promotes angiogenesis in breast cancer

    Zheng, Lufeng; Li, Xiaoman; Gu, Yi; Ma, Yihua; Xi, Tao, E-mail: xitao18@hotmail.com

    2014-10-24

    Highlights: • A new critical role of pseudogene CYP4Z2P 3′UTR in breast cancer is proposed. • We examine the level of pseudogene CYP4Z2P 3′UTR in breast cancer tissues. • The functions of CYP4Z2P 3′UTR and mechanism were studied. • The mechanism provides new insights for the breast cancer progression. - Abstract: Pseudogenes have long been marked as “false” genes, which are similar with real genes but have no apparent function. The 3′UTR is well-known to regulate gene expression post-transcriptionally. Our recent evidence, however, indicates novel functional roles of pseudogene CYP4Z2P 3′UTR (Z2P-UTR). We found that ectopic expression of Z2P-UTR in breast cancer cells significantly increased the expression of VEGF-A without affecting cell proliferation in vitro. Meanwhile, conditioned medium (CM) from Z2P-UTR overexpression cells enhanced proliferation, migration and tube formation of HUVEC, and promoted angiogenesis in ex vivo models. Also, CM increased the expression of VEGFR2 in HUVEC. Our data suggest that Z2P-UTR can promote breast cancer angiogenesis partly via paracrine pathway of VEGF-A/VEGFR2.

  3. Pseudogene CYP4Z2P 3′UTR promotes angiogenesis in breast cancer

    Highlights: • A new critical role of pseudogene CYP4Z2P 3′UTR in breast cancer is proposed. • We examine the level of pseudogene CYP4Z2P 3′UTR in breast cancer tissues. • The functions of CYP4Z2P 3′UTR and mechanism were studied. • The mechanism provides new insights for the breast cancer progression. - Abstract: Pseudogenes have long been marked as “false” genes, which are similar with real genes but have no apparent function. The 3′UTR is well-known to regulate gene expression post-transcriptionally. Our recent evidence, however, indicates novel functional roles of pseudogene CYP4Z2P 3′UTR (Z2P-UTR). We found that ectopic expression of Z2P-UTR in breast cancer cells significantly increased the expression of VEGF-A without affecting cell proliferation in vitro. Meanwhile, conditioned medium (CM) from Z2P-UTR overexpression cells enhanced proliferation, migration and tube formation of HUVEC, and promoted angiogenesis in ex vivo models. Also, CM increased the expression of VEGFR2 in HUVEC. Our data suggest that Z2P-UTR can promote breast cancer angiogenesis partly via paracrine pathway of VEGF-A/VEGFR2

  4. Peer-to-Peer (P2P) Knowledge, Use, and Attitudes of Academic Librarians

    Hendrix, Dean

    2007-01-01

    To assess their knowledge, use, and attitudes regarding peer-to-peer (P2P) applications, this study surveyed academic librarians (n = 162) via a mail-in survey. Correlations between the sample characteristics (age, gender, year of MLS, type of library job) and P2P knowledge, use, and attitudes were also explored. Overall, academic librarians…

  5. SAPIR - Executing complex similarity queries over multi layer P2P search structures

    Falchi, Fabrizio; Batko, Michal

    2009-01-01

    This deliverable reports the activities conducted within Task 5.4 "Executing complex similarity queries over multi layer P2P search structures" of the SAPIR project. In particular the deliverable discusses complex similarity queries issues and the implementation of the query processing over the P2P indexing. The document is accompanied by a zip file containing the javadoc for MUFIN.

  6. PD2P : PanDA Dynamic Data Placement for ATLAS

    CERN. Geneva

    2012-01-01

    The PanDA Dynamic Data Placement (PD2P) system has been developed to cope with difficulties of data placement for ATLAS. PD2P is an intelligent subsystem of PanDA to distribute data by taking the following factors into account: popularity, locality, the usage pattern of the data, the distribution of CPU and storage resources, ...

  7. A Trust Scheme Based DRM Model for P2P System

    XIAO Shangqin; LU Zhengding; LING Hefei; ZOU Fuhao

    2006-01-01

    With the maturation of P2P technology, there are more and more challenges to the protection of digital rights.DRM for traditional Client/Server model can not satisfy the requirement of digital right protection of P2P network.With practical application of P2P network technology and new generational DRM technology, the article proposes a DRM model for P2P system based on trust degree.The proposed model shares the secret key to the trusty peers and affords necessary security ensure for digital content delivery based on P2P technology.Mathematic analyses and simulations show that, compared to the current DRM model, the proposed model is more robust toleration of transmit and security.

  8. A Free-Rider Forecasting Model Based on Gray System Theory in P2P Networks

    He Xu

    2012-11-01

    Full Text Available The aim of this study is to forecast the number of free-riders in P2P networks which can help network managers to know the status of the networks in advance and take appropriate measures to cope with free-riding behavior. Free-riding behavior is common in P2P networks, which has a negative impact on the robustness, availability and stability of the networks. Severe free-riding behavior may lead to the crash of the whole P2P application system. Based on the research of free-riding behavior in P2P networks, this paper constructs a free-rider forecasting model (GST model using Gray System Theory. Simulation experiments show that this model has high feasibility, and can carry out reasonable predictions on the number of free-riders in P2P networks.

  9. Computing and Routing for Trust in Structured P2P Network

    Biao Cai

    2009-09-01

    Full Text Available Study of trust in P2P network now is focus on how to effectively against various malicious behaviors such as providing fake or misleading feedback about other peers and the management of trust in a P2P environment. But the scotoma of portability that trust peer can join (leave a certain P2P network at anytime and anywhere is seldom discussed. In this paper, a structured topology for trusts management in portable P2P network based on DHT (discrete hash table is proposed first, in which includes trust management strategies and peer operations on certain DHT circle. After that, a novel trust-computing model for the structured P2P network and the main trust decisions in the structured network are introduced too. Effectiveness and practicality of the proposed trust management have been showed in simulation experiments at the end.

  10. SPF-A*: Searching Multimedia Data in Heterogeneous Mobile P2P Network

    Fan Ye

    2009-04-01

    Full Text Available Mobile P2P (MP2P network has been widely used in everyday life combined with the wireless technology development. However, most previous works concentrate on the assumption that the mobile peers are identical of their inner properties in compositing a MP2P network. However, in current network environment, heterogeneous devices are widely used; they may have different storage sizes, data transmission rate, processing ability and even security levels. In such kind of MP2P Network environment, how to make data transmission effectively is challenge. In this paper, we concentrate on how to effectively obtain a queried multimedia resource and generate a path for such data transmission on the overlay MP2P network, so as to make the resource more effectively transmit among the heterogeneous peers. A new path generating algorithm called SPF-A* (Super Peer First A* is devised, and simulation studies are conducted to validate our proposal.

  11. An Anti-attack Model Based on Complex Network Theory in P2P networks

    Peng, Hao; Zhao, Dandan; Zhang, Aixin; Li, Jianhua

    2011-01-01

    Complex network theory is a useful way to study many real systems. In this paper, an anti-attack model based on complex network theory is introduced. The mechanism of this model is based on dynamic compensation process and reverse percolation process in P2P networks. The main purpose of the paper is: (i) a dynamic compensation process can turn an attacked P2P network into a power-law (PL) network with exponential cutoff; (ii) a local healing process can restore the maximum degree of peers in an attacked P2P network to a normal level; (iii) a restoring process based on reverse percolation theory connects the fragmentary peers of an attacked P2P network together into a giant connected component. In this way, the model based on complex network theory can be effectively utilized for anti-attack and protection purposes in P2P networks.

  12. Convergence of Internet and TV: The Commercial Viability of P2P Content Delivery

    de Boever, Jorn

    The popularity of (illegal) P2P (peer-to-peer) file sharing has a disruptive impact on Internet traffic and business models of content providers. In addition, several studies have found an increasing demand for bandwidth consuming content, such as video, on the Internet. Although P2P systems have been put forward as a scalable and inexpensive model to deliver such content, there has been relatively little economic analysis of the potentials and obstacles of P2P systems as a legal and commercial content distribution model. Many content providers encounter uncertainties regarding the adoption or rejection of P2P networks to spread content over the Internet. The recent launch of several commercial, legal P2P content distribution platforms increases the importance of an integrated analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT).

  13. Dsj meson decay in the C{sup 3}P{sub 0} model

    Silva, D.T. da; Silva, M.L.L. da; Quadros, J.N. de; Vasconcellos, C.A.Z.; Hadjimichef, D. [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil)

    2010-07-01

    Full text. Fock-Tani is a field theory formalism appropriated for the simultaneous treatment of composite particles and their constituents. The formalism was originally developed for the treatment of problems in atomic physics and it was extended later on to the treatment of problems on hadron physics. In the Fock-Tani formalism one starts with the Fock representation of the system using field operators of elementary constituents which satisfy canonical (anti) commutation relations. Composite-particle field operators are linear combinations of the elementary-particle operators and do not generally satisfy canonical (anti) commutation relations. 'Ideal' field operators acting on an enlarged Fock space are then introduced in close correspondence with the composite ones. Next, a given unitary transformation, which transforms the single composite states into single ideal states, is introduced. Application of the unitary operator on the microscopic Hamiltonian, or on other hermitian operators expressed in terms of the elementary constituent field operators, gives equivalent operators which contain the ideal field operators. The effective Hamiltonian in the new representation has a clear physical interpretation in terms of the processes it describes. Since all field operators in the new representation satisfy canonical (anti)commutation relations, the standard methods of quantum field theory can then be readily applied. For a long time the pair creation models for strong hadronic decays have been formulated. The {sup 3}P{sub 0} model is typical decay model which considers only OZI-allowed strong decays. The {sup 3}P{sub 0} model considers a quark-antiquark par creation in the presence of the initial state meson. The quark-antiquark par is created with the vacuum quantum numbers. This model can also be obtained from the non-relativistic limit of the pair creation Hamiltonian. Applying the Fock-Tani transformation to the pair creation Hamiltonian produces the

  14. MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.

    Fordham, Jezrom B; Guilfoyle, Katherine; Naqvi, Afsar Raza; Nares, Salvador

    2016-01-01

    MicroRNA are small, non-coding, single-stranded RNAs that are estimated to regulate ~60% of the human genome. MiRNA profiling of monocyte-to-osteoclast differentiation identified miR-142-3p as a miRNA that is significantly, differentially expressed throughout osteoclastogenesis. Enforced expression of miR-142-3p via transient transfection with miR-142-3p mimic inhibited cell-to-cell contact and fusion, decreased protein kinase C alpha expression, and ultimately reduced cell viability. miR-142-3p was also identified as significantly differentially expressed during monocyte-to-macrophage differentiation and overexpression of miR-142-3p prevented their conversion to osteoclasts. Furthermore, the inhibitory effect of miR-142-3p on osteoclastogenesis extended to the conversion of a third osteoclast precursor cell type- dendritic cells. These results demonstrate miR-142-3p to be a negative regulator of osteoclastogenesis from the 3 main precursor cell types: monocytes, macrophages and dendritic cells. Importantly, decreased survival was dependent upon both miR-142-3p expression and RANK-signaling, with no harmful effects detected in the absence of this combination. As such, miR-142-3p represents a novel target for the selective removal of osteoclasts by targeting of osteoclastogenic pathways. PMID:27113904

  15. MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-δ1.

    Wu, Shifeng; Du, Xinjie; Wu, Manwu; Du, Hechun; Shi, Xiaoliang; Zhang, Tao

    2016-06-10

    Osteosarcoma is the most common primary bone cancer which is associated with early metastatic potential and poor prognosis. However, the molecular mechanisms underlying osteosarcoma progression are not well characterized. Here, we investigated the role of miR-409-3p in osteosarcoma metastasis. Osteosarcoma tissue showed decreased expression of miR-409-3p compared to adjacent non-tumorous tissue. The expression level of miR-409-3p was negatively correlated with osteosarcoma metastasis. Overexpression of miR-409-3p in osteosarcoma cells (U2OS) inhibited cell migration and invasion. Bioinformatics analysis showed that catenin-δ1 (CTNND1, p120-catenin) is a direct target of miR-409-3p. Overexpression of miR-409-3p repressed the expression of catenin-δ1 in U2OS cells at both mRNA and protein levels. Meanwhile, miR-409-3p repressed the activity of luciferase reporter containing the 3'-untranslated region (3'UTR) of CTNND1 gene. Furthermore, expression of catenin-δ1 rescued the inhibitory effect of miR-409-3p on cell migration and invasion. Altogether, these results indicated that miR-409-3p targets catenin-δ1 to repress osteosarcoma metastasis. PMID:26992637

  16. A quasi-particle description of the M(3,p) models

    Jacob, P.; Mathieu, P

    2005-01-01

    The M(3,p) minimal models are reconsidered from the point of view of the extended algebra whose generators are the energy-momentum tensor and the primary field \\phi_{2,1} of dimension $(p-2)/4$. Within this framework, we provide a quasi-particle description of these models, in which all states are expressed solely in terms of the \\phi_{2,1}-modes. More precisely, we show that all the states can be written in terms of \\phi_{2,1}-type highest-weight states and their phi_{2,1}-descendants. We fu...

  17. Absolute frequency measurement of the 1S0 - 3P0 transition of 171Yb

    Pizzocaro, Marco; Rauf, Benjamin; Bregolin, Filippo; Milani, Gianmaria; Clivati, Cecilia; Costanzo, Giovanni A; Levi, Filippo; Calonico, Davide

    2016-01-01

    We report the absolute frequency measurement of the unperturbed transition 1S0 - 3P0 at 578 nm in 171Yb realized in an optical lattice frequency standard. The absolute frequency is measured 518 295 836 590 863.55(28) Hz relative to a cryogenic caesium fountain with a fractional uncertainty of 5.4x10-16 . This value is in agreement with the ytterbium frequency recommended as a secondary representation of the second in the International System of Units.

  18. Photoionization from the excited (3p, 3d, 4s, 4p) states of sodium

    Calculations are presented for the total cross section (σ) and the angular distribution of asymmetry parameter (β) for photoionization from initial excited (3p, 3d, 4s and 4p) states of sodium atom. Comparison of our results for σ and β is made with other available theoretical calculations and the experimental data. We also present results for the angular distributions in electron-Na+ elastic scattering at energies of k 0.5 and 1.0 a0. (author). 43 refs., 7 figs., 2 tabs

  19. Gene-centric Association Mapping of Chromosome 3p implicates MST1 in IBD pathogenesis

    Goyette, Philippe; Ng, Aylwin; Lefebvre, Céline; Brant, Steven R.; Cho, Judy H; Duerr, Richard H.; Silverberg, Mark S; Kent D. Taylor; Latiano, Anna; Aumais, Guy; Deslandres, Colette; Jobin, Gilles; Annese, Vito; Daly, Mark J.; Xavier, Ramnik J.

    2008-01-01

    Association mapping and candidate gene studies within IBD linkage regions, as well as genome-wide association studies in CD have led to the discovery of multiple risk genes, but these only explain a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and UC using a gene-centric association mapping approach. We identified twelve functional candidate genes by searching for literature co-citations with relevant k...

  20. Electron-phonon superconductivity in $A$Pt$_3$P compounds: from weak to strong coupling

    Subedi, Alaska; Ortenzi, Luciano; Boeri, Lilia

    2012-01-01

    We study the newly discovered Pt phosphides $A$Pt$_3$P ($A$=Sr, Ca, La) [ T. Takayama et al. Phys. Rev. Lett. 108, 237001 (2012)] using first-principles calculations and Migdal-Eliashberg theory. Given the remarkable agreement with the experiment, we exclude the charge-density wave scenario proposed by previous first-principles calculations, and give conclusive answers concerning the superconducting state in these materials. The pairing increases from La to Ca and Sr due to changes in the ele...

  1. sup 3 P sub 0 study of meson decays in a chiral quark model

    Bonnaz, R; Silvestre-Brac, B; Fernández, F; Valcarce, A

    2001-01-01

    The strong decays of a meson into two mesons are studied in the framework of the sup 3 P sub 0 model. The meson wave functions are determined by means of a realistic chiral quark model constructed in the baryon sector and comparison is made with a traditional potential of 'Coulomb + linear' type. Two different forms for the creation vertex are analyzed. A momentum dependent vertex is proved to be definitively superior. The chiral quark model provides an overall good description of all known transitions and gives results of roughly the same quality as those obtained from phenomenological quark-antiquark potentials.

  2. Diagnostic value of solitary pulmonary nodules using 99Tm-3P4-RGD2 scintigraphy

    Objective: To investigate the value of 99Tcm-HYNIC-(poly-(ethylene glycol), PEG)4-E (PEG4-c(RGDfK))2 (99Tcm-3P4-RGD2) SPECT imaging in the diagnosis of SPN by visual and semiquantitative analysis.Methods Twenty-one patients (13 men, 8 women; age range 37-77 (58±11) years) with SPN observed on CT were analyzed prospectively. All patients underwent SPECT imaging after administration of 99Tcm-3P4-RGD2 with a dose of (939 ± 118) MBq. The gold standard was based on the histopathological diagnosis of the surgical samples from all recruited patients. The diagnostic performance of CT, SPECT visual and semiquantitative analysis was compared and analyzed with ROC curves. Immunohistochemistry was performed in part of the samples to obtain the information of integrin αvβ3 expression. Informed consent was obtained from all patients. Application of a new radiopharmaceutical was permitted and approved by the local independent Ethics Committee and the Institutional Review Board of the China-Japan Union Hospital. One-way analysis of variance,two-sample t test were used with SPSS 13.0. Results: Among the 21 SPN patients, 15 cases (71%) were diagnosed as malignant, and the other 6 (29%) were benign. T/NT ratio in malignant SPN was higher than that in benign SPN (1.87 ± 0.39 vs 1.41 ± 0.65), but with no statistical significance (t=2.01, P>0.05). The sensitivities for CT, SPECT visual and semiquantitative analysis were 80% (12/15), 100% (15/15) and 100% (15/15) respectively,and the specificity were all 4/6. The AUC was 0.811 (95% CI 58%-95%) for CT, 0.833 (95% CI 61%-96%) for SPECT and 0.844 (95% CI 62%-96%) for T/NT ratios, which showed no statistical significance (F=0.83, P>0.05). Immunohistochemistry confirmed αvβ3 expression in both the malignant and benign nodules which had uptake of 99Tcm-3P4-RGD2 in SPECT imaging. Conclusion: SPECT visual and semiquantitative analysis with 99Tcm-3P4-RGD2 appears to have high sensitivity and consistency in diagnosis of SPN. (authors)

  3. Quantum chaos in ultracold collisions between Yb($^1$S$_0$) and Yb($^3$P$_2$)

    Green, Dermot G; Frye, Matthew D; Morita, Masato; Hutson, Jeremy M

    2015-01-01

    We calculate and analyze Feshbach resonance spectra for ultracold Yb($^1$S$_0$) + Yb($^3$P$_2$) collisions as a function of an interatomic potential scaling factor $\\lambda$ and external magnetic field. We show that, at zero field, the resonances are distributed randomly in $\\lambda$, but that signatures of quantum chaos emerge as a field is applied. The random zero-field distribution arises from superposition of structured spectra associated with individual total angular momenta. In addition, we show that the resonances in magnetic field in the experimentally accessible range 400 to 2000~G are chaotically distributed, with strong level repulsion that is characteristic of quantum chaos.

  4. High current Cu3P liquid metal ion source using a novel extractor configuration

    Higuchi-Rusli, R. H.; Corelli, J. C.

    1987-12-01

    It has been found that by utilizing a sharp needle for the extractor electrode in close proximity to the source tip wetted with Cu3P liquid alloy, a large increase (factor ˜300) in ion current is observed in comparison to standard liquid metal ion sources (LMIS's). In standard previously used LMIS's the extractor electrode was a flat plane with a circular hole centered on the source needle tip. This new high current source has important applications in focused and broad ion beam deposition systems.

  5. Pulsar Spin-Down by 3P2 Superfluid Neutron with Field Decay

    LUO Xin-Lian; PENG Qiu-He; CHOU Chih-Kang

    2003-01-01

    To describe pulsar spin-down, we present a simple combined torque model that takes into account both the standard magnetic dipole radiation and the electromagnetic radiation from the 3P2 superSuid vortex neutrons inside neutron star. Using an ordinary exponential model for the magnetic field decay, we derive an analytical formulae for pulsar evolution tracks. The pulsar evolution on the P-P diagram is quite different from that of the standard magnetic dipole radiation model, especially when the supernuid torque or Geld decay becomes dominant.

  6. MiR-519d-3p suppresses invasion and migration of trophoblast cells via targeting MMP-2.

    Jie Ding

    Full Text Available Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military Medical University and complied strictly with national ethical guidelines. Preeclampsia (PE is a specific clinical disorder characterized by gestational hypertension and proteinuria and is a leading cause of maternal and perinatal mortality worldwide. The miR-519d-3p is upregulated in the maternal plasma of patients with PE which indicates a possible association between this microRNA and the pathogenesis of PE. No studies to date have addressed the effect of miR-519d-3p on the invasion and migration of trophoblast cells. In our study, we found that miR-519d-3p expression was elevated in placental samples from patients with PE. In vitro, overexpression of miR-519d-3p significantly inhibited trophoblast cell migration and invasion, whereas transfection of a miR-519d-3p inhibitor enhanced trophoblast cell migration and invasion. Luciferase assays confirmed that matrix metalloproteinase-2 (MMP-2 is a direct target of miR-519d-3p. Quantitative real-time PCR and western blot assays showed that overexpression of miR-519d-3p downregulated MMP-2 mRNA and protein expression. Knockdown of MMP-2 using a siRNA attenuated the increased trophoblast migration and invasion promoted by the miR-519d-3p inhibitor. In placentas from patients with PE or normal pregnancies, a negative correlation between the expression of MMP-2 and miR-519d-3p was observed using the Pearson correlation and linear regression analysis. Our present findings suggest that upregulation of miR-519d-3p may contribute to the development of PE by inhibiting trophoblast cell migration and invasion via targeting MMP-2; miR-519d-3p may represent a potential predictive and therapeutic target for PE.

  7. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.

    Chim, Nicholas; Gall, Walter E; Xiao, Jing; Harris, Mark P; Graham, Todd R; Krezel, Andrzej M

    2004-03-01

    The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid trafficking. While investigating the 287-residue N-terminal region of Swa2p, we found a single stably folded domain between residues 140 and 180. Using binding assays and structural analysis, we established this to be a ubiquitin-associated (UBA) domain, unidentified by bioinformatics of the yeast genome. We determined the solution structure of this Swa2p domain and found a characteristic three-helix UBA fold. Comparisons of structures of known UBA folds reveal that the position of the third helix is quite variable. This helix in Swa2p UBA contains a bulkier tyrosine in place of smaller residues found in other UBAs and cannot pack as close to the second helix. The molecular surface of Swa2p UBA has a mostly negative potential, with a single hydrophobic surface patch found also in the UBA domains of human protein, HHR23A. The presence of a UBA domain implicates Swa2p in novel roles involving ubiquitin and ubiquitinated substrates. We propose that Swa2p is a multifunctional protein capable of recognizing several proteins through its protein-protein recognition domains. PMID:14997574

  8. A New Case of an Extremely Rare 3p21.31 Interstitial Deletion.

    Lovrecic, Luca; Bertok, Sara; Žerjav Tanšek, Mojca

    2016-05-01

    Interstitial 3p21.31 deletions have been very rarely reported. We describe a 7-year-old boy with global developmental delay, specific facial characteristics, hydronephrosis, and hypothyreosis with a de novo deletion of 3p21.31, encompassing 29 OMIM genes. Despite the wide use of microarrays, no similar case has been reported in the literature so far. Five overlapping cases are deposited in the DECIPHER database, 2 of which have significant overlapping chromosomal aberrations. They both share some phenotypic characteristics with our case, e.g. developmental delay, intellectual disability and facial dysmorphism (arched eyebrows, hypertelorism, low-set ears, and a large nose tip). In addition, loss-of-function mutations in the SETD2 gene (OMIM 612778) of the deleted region have been described in 3 patients, presenting with some similar clinical features, namely overgrowth, intellectual disability, speech delay, hypotonia, autism, and epilepsy. Therefore, SETD2 may explain part of the phenotype in our case. We focused on 3 other genes in the deleted region, based on their known functions, namely CSPG5 (OMIM 606775), PTH1R (OMIM 168468) and SMARCC1 (OMIM 601732), and assessed their potentially important role in describing the patient's phenotype. Additional cases with haploinsufficiency of this region are needed to elucidate further genotype-phenotype correlations. PMID:27385966

  9. Optical potentials for Ne*(3P2,0)-Ar, N2 interactions

    Baudon, J.; Feron, P.; Miniatura, C.; Perales, F.; Reinhardt, J.; Robert, J.; Haberland, H.; Brunetti, B.; Vecchiocattivi, F.

    1991-08-01

    The differential elastic cross sections for Ne*(3P2,0)-Ar and Ne*(3P2,0)-N2 collisions have been measured in crossed beam experiments at 0.064 and 0.318 and at 0.071 and 0.295 eV, collision energies, respectively. These results have been analyzed simultaneously with integral cross sections and total ionization cross sections already available and optical spherical potentials for these two systems have been obtained. These potentials appear to be rather accurate in the distance range from 2.5 to ˜9 and from 3.0 to ˜9 Å for Ne*-Ar and Ne*-N2, respectively. The well depths and equilibrium distances are 5.12 meV and 4.9 Å for Ne*-Ar and 3.56 meV and 5.40 Å for Ne*-N2. The short-range repulsion in both cases exhibits a change in slope which can be correlated with the influence, for the interaction at shorter distances, of the Ne+ core of the metastable atom, which becomes less effective when the intermolecular distance increases. The optical potentials proposed here are given in analytical form suitable for the calculation of dynamical observables of these systems.

  10. A Mixed-Valent Molybdenum Monophosphate with a Layer Structure: KMo 3P 2O 14

    Guesdon, A.; Borel, M. M.; Leclaire, A.; Grandin, A.; Raveau, B.

    1994-03-01

    A new mixed-valent molybdenum monophosphate with a layer structure KMo 3P 2O 14 has been isolated. It crystallizes in the space group P2 1/ m with a = 8.599(2) Å, b = 6.392(2) Å, c = 10.602(1) Å, and β = 111.65(2)°. The layers [Mo 3P 2O 14] ∞ are parallel to (100) and consist of [MoPO 8] ∞ chains running along limitb→ , in which one MoO 6 octahedron alternates with one PO 4 tetrahedron. In fact, four [MoPO 8] ∞ chains share the corners of their polyhedra and the edges of their octahedra, forming [Mo 4P 4O 24] ∞ columns which are linked through MoO 5 bipyramids along limitc→. The K + ions interleaved between these layers are surrounded by eight oxygens, forming bicapped trigonal prisms KO 8. Besides the unusual trigonal bipyramids MoO 5, this structure is also characterized by a tendency to the localization of the electrons, since one octahedral site is occupied by Mo(V), whereas the other octahedral site and the trigonal bipyramid are occupied by Mo(VI). The similarity of this structure with pure octahedral layer structures suggests the possibility of generating various derivatives, and of ion exchange properties.

  11. Molecular physiology of pH-sensitive background K(2P) channels.

    Lesage, Florian; Barhanin, Jacques

    2011-12-01

    Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K(2P) channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K(2P) channels. PMID:22170960

  12. A Free-Rider Forecasting Model Based on Gray System Theory in P2P Networks

    He Xu; Zhao-xiong Zhou; Suo-ping Wang; Ru-chuan Wang

    2012-01-01

    The aim of this study is to forecast the number of free-riders in P2P networks which can help network managers to know the status of the networks in advance and take appropriate measures to cope with free-riding behavior. Free-riding behavior is common in P2P networks, which has a negative impact on the robustness, availability and stability of the networks. Severe free-riding behavior may lead to the crash of the whole P2P application system. Based on the research of free-riding behavior in ...

  13. Pre-Paid Charging System for Sip-P2P Commercial Applications

    Damian Nowak; Krzysztof Walkowiak

    2011-01-01

    The new SIP-P2P approach brings many advantages like the improved reliability and the ease of setup.However, Communications Service Providers (CSPs) offering VoIP services seem to be afraid to losetheir profits due to the introduction of SIP-P2P. Claimed is the lack of session establishment controlleading to revenue leakages. In this work we introduce a charging system for SIP-P2P that assures CSPs’revenue from using SIP-based peer-to-peer communications commercially. The proposed solutioncon...

  14. THash: A Practical Network Optimization Scheme for DHT-based P2P Applications

    Sun, Yi; Yang, Richard; Zhang, Xiaobing; Guo, Yang; Li, Jun; Salamatian, Kavé

    2013-01-01

    International audience P2P platforms have been criticized because of the heavy strain that they can inflict on costly inter-domain links of network operators. It is therefore mandatory to develop network optimization schemes for controlling the load generated by a P2P platform on an operator network. While many research efforts exist on centralized tracker-based systems, in recent years multiple DHT-based P2P platforms have been widely deployed and considered as commercial services due to ...

  15. CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF YEAST ARTIFICIAL CHROMOSOMES CONTAINING HUMAN 3P13-P21-SPECIFIC SEQUENCE-TAGGED SITES

    MICHAELIS, SC; BARDENHEUER, W; LUX, A; SCHRAMM, A; GOCKEL, A; SIEBERT, R; WILLERS, C; SCHMIDTKE, K; TODT, B; VANDERHOUT, AH; BUYS, CHCM; HEPPELLPARTON, AC; RABBITTS, PH; UNGAR, S; SMITH, D; LEPASLIER, D; COHEN, D; OPALKA, B; SCHUTTE, J

    1995-01-01

    Human chromosomal region 3p12-p23 is proposed to harbor at least three tumor suppressor genes involved in the development of lung cancer, renal cell carcinoma, and other neoplasias. In order to identify one of these genes we defined sequence tagged sites (STSs) specific for 3p13-p24.2 by analyzing a

  16. Interaction between 4p photoionization and 3p resonant excitation channels of krypton

    Complete text of publication follows. The angular distribution of Kr 4p photoelectrons was measured employing a linearly polarized photon beam at energies from 205 eV to 230 eV. In this range the Kr 3p→ns/md (n,m=4,5,6, etc.) resonances can be excited. The experimental anisotropy parameters (β, γ and δ) were determined for the Kr 4p shell and its fine structure components. The measurement was carried out at beamline BW3 of the DORIS III synchrotron light source at HASYLAB (Hamburg, Germany). The ESA-22D electrostatic electron spectrometer was used to analyze the emitted electrons. The spectrometer consists of a spherical and a cylindrical mirror analyzer. The spherical mirror focuses the electrons from the scattering plane to the entrance slit of the cylindrical analyzer performing the energy analysis of the electrons. (For detailed description of an ESA- 22-type electron spectrometer see Ref. [1].) The measured dipole anisotropy parameters ? of Kr 4p photoelectrons are shown in Fig. 1 as a function of photon energy. Resonance-like structure can be seen in the photon energy dependence of the dipole parameters. This structure indicates that the channel interactions are important between the 3p resonant excitation-autoionization and 4p direct photoionization processes in krypton. The natural line width of the 3p photoelectron peaks was determined from the measured spectra and it is about 0.8 eV while the experimental width of the resonance near 220 eV photon energy (3p1/2-1→5s resonant excitation) is approximately 2 eV in Fig. 1. This broadening can be explained with the strong interference between the ionization and excitation channels. As before, we conclude that the angular distribution of photoelectrons is strongly influenced by the excitation processes. Acknowledgements. The authors wish to thank the DORIS III staff for providing excellent working conditions. This work was supported by the NKTH-OTKA (Grant No. K67719), and by the European Community

  17. MicroRNA-490-3p inhibits proliferation of A549 lung cancer cells by targeting CCND1

    Highlights: • We examined the level of miR-490-3p in A549 lung cancer cells compared with normal bronchial epithelial cell line. • We are the first to show the function of miR-490-3p in A549 lung cancer cells. • We demonstrate CCND1 may be one of the targets of miR-490-3p. - Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate the translation of messenger RNAs by binding their 3′-untranslated region (3′UTR). In this study, we found that miR-490-3p is significantly down-regulated in A549 lung cancer cells compared with the normal bronchial epithelial cell line. To better characterize the role of miR-490-3p in A549 cells, we performed a gain-of-function analysis by transfecting the A549 cells with chemically synthesized miR-490-3P mimics. Overexpression of miR-490-3P evidently inhibits cell proliferation via G1-phase arrest. We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1, which plays a key role in G1/S phase transition. In addition, the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3′UTR. These findings indicated miR-490-3P could be a potential suppressor of cellular proliferation

  18. Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae.

    Soracom Chardwiriyapreecha

    Full Text Available In Saccharomyces cerevisiae, Avt3p and Avt4p mediate the extrusion of several amino acids from the vacuolar lumen into the cytosol. SpAvt3p of Schizosaccharomyces pombe, a homologue of these vacuolar amino acid transporters, has been indicated to be involved in spore formation. In this study, we confirmed that GFP-SpAvt3p localized to the vacuolar membrane in S. pombe. The amounts of various amino acids increased significantly in the vacuolar pool of avt3Δ cells, but decreased in that of avt3+-overexpressing avt3Δ cells. These results suggest that SpAvt3p participates in the vacuolar compartmentalization of amino acids in S. pombe. To examine the export activity of SpAvt3p, we expressed the avt3+ gene in S. cerevisiae cells. We found that the heterologously overproduced GFP-SpAvt3p localized to the vacuolar membrane in S. cerevisiae. Using the vacuolar membrane vesicles isolated from avt3+-overexpressing S. cerevisiae cells, we detected the export activities of alanine and tyrosine in an ATP-dependent manner. These activities were inhibited by the addition of a V-ATPase inhibitor, concanamycin A, thereby suggesting that the activity of SpAvt3p is dependent on a proton electrochemical gradient generated by the action of V-ATPase. In addition, the amounts of various amino acids in the vacuolar pools of S. cerevisiae cells were decreased by the overproduction of SpAvt3p, which indicated that SpAvt3p was functional in S. cerevisiae cells. Thus, SpAvt3p is a vacuolar transporter that is involved in the export of amino acids from S. pombe vacuoles.

  19. LANC: locality-aware network coding for better P2P traffic localization

    Zhang, Guoqiang; Zhang, Guoqing

    2010-01-01

    As ISPs begin to cooperate to expose their network locality information as services, e.g., P4P, solutions based on locality information provision for P2P traffic localization will soon approach their capability limits. A natural question is: can we do any better provided that no further locality information improvement can be made? This paper shows how the utility of locality information could be limited by conventional P2P data scheduling algorithms, even as sophisticated as the local rarest first policy. Network coding's simplified data scheduling makes it competent for improving P2P application's throughput. Instead of only using locality information in the topology construction, this paper proposes the locality-aware network coding (LANC) that uses locality information in both the topology construction and downloading decision, and demonstrates its exceptional ability for P2P traffic localization. The randomization introduced by network coding enhances the chance for a peer to find innovative blocks in it...

  20. High-temperature behavior of vanadyl pyrophosphate (VO)2P2O7

    (VO)2P2O7 has been studied at high temperatures by in situ X-ray powder diffraction in an inert atmosphere. Lattice parameters indicate an anisotropic thermal expansion up to Tc=214-bar C, followed by an approximately isotropic expansion up to 490-bar C. It is proposed that Tc is the temperature of a second-order phase transition between the known room temperature form with space group Pca21 and a high-temperature form with space group Pcab. Above 490-bar C a minority phase develops in the sample that was identified as the V3+ containing compound V4(P2O7)3, while the anisotropic expansion along a suggests that stoichiometric (VO)2P2O7 transforms into (VO)2P2O7+x with interstitial oxygen located between the layers. With an onset at 706-bar C all of the (VO)2P2O7 transforms into VPO4

  1. High pressure studies of the phase transition in the ferroelectric Sn2P2S6

    Dzhavadov, Leonid N.; Ryzhov, Valentin N.

    2016-06-01

    We apply a method of pulse-adiabatic modulation of pressure to obtain heat capacity and thermal expansion of ferroelectric Sn2P2S6 in the vicinity of the second order phase transition at pressures to 5 kbar. The phase transition in Sn2P2S6 does not change its nature and stays second order in the whole range of pressure currently studied. The earlier conclusion on the tricritical features of the phase transition in Sn2P2S6 cannot be confirmed. Discontinuities of heat capacity and thermal expansion perfectly fit the Ehrenfest equation that expected in the mean field theories. An excellent performance of the Ehrenfest formula in a wide range of pressures establishes phase transition in Sn2P2S6 as an almost ideal mean field phase transition.

  2. A Local Scalable Distributed EM Algorithm for Large P2P Networks

    National Aeronautics and Space Administration — his paper describes a local and distributed expectation maximization algorithm for learning parameters of Gaussian mixture models (GMM) in large peer-to-peer (P2P)...

  3. Pre-Paid Charging System for Sip-P2P Commercial Applications

    Damian Nowak

    2011-03-01

    Full Text Available The new SIP-P2P approach brings many advantages like the improved reliability and the ease of setup.However, Communications Service Providers (CSPs offering VoIP services seem to be afraid to losetheir profits due to the introduction of SIP-P2P. Claimed is the lack of session establishment controlleading to revenue leakages. In this work we introduce a charging system for SIP-P2P that assures CSPs’revenue from using SIP-based peer-to-peer communications commercially. The proposed solutionconsists of a new “carrier-grade P2P network” concept, software modification of existing equipment andgives some charging application design guidelines. An application prototype was implemented toexamine the concept. Additionally, experiments were done to provide the methodology for systemdimensioning.

  4. Implementing a Secure Key Issuing Scheme for Communication in P2P Networks

    Mohammed Azharuddin

    2012-03-01

    Full Text Available Key issuing scheme focuses on the confidentiality maintained in using the secret key for communicationin p2p networks. Identity based cryptography (IBC was introduced into peer-to-peer (P2P networks recently for identity verification and authentication purposes. However, current IBC-based solutions were not addressing the problem of secure private key issuing. In this paper we propose a novel secure key issuing scheme for P2P networks using IBC. We present an IBC infrastructure setup phase, a peer registration solution using Shamir’s (k, n secret sharing scheme, and a secure key issuing scheme, which adopts key generate centre (KGC and key privacy authorities (KPAs to issue private keys to peers securely. This enables the IBC systems to be more acceptable and applicable in real-world P2P networks.

  5. The Number of Solutions of the Diophantine Equation x2 + p2 =yn%Diophantine方程x2+p2=yn的解数

    梁明

    2013-01-01

    Let p be a fixed odd prime,and let N(p) denote the number of positive integer solutions (x,y,n) of the equation x2 +p2 =yn satisfying gcd(x,y)=1 and n > 2.In this paper we prove that if p ≠ 7,then N(p) < log p.%对于给定的奇素数p,设N(p)为方程x2+ p2=yn满足gcd(x,y)=1和n>2的正整数解(x,y,n)的个数,本文证明了:当p≠7时,N(p) <log p.

  6. Photodissociation laser at the 2P1/2-2P3/2 fine-structure transition of the chlorine atom

    Bokun, V.CH.; Gordon, E.B.; Krasnoperov, L.N.; Sotnichenko, S.A.; Chichinin, A.I.

    1986-07-01

    Stimulated emission at the 2P1/2-2P3/2 transition of the chlorine atom (during the dissociation of ICl molecules) is reported. The lasing energy (at 11.35 microns) is investigated as a function of the pumping energy and ICl pressure; the gain coefficient is determined to be (2.5 + or - 0.5) x 10 to the -3rd per cm, the lasing energy is approximately equal to 1 mJ. It is noted that the chemical depopulation of the lower laser level and atomic recombination play an important role in population inversion and medium recovery. The rate constants of the spin-orbital relaxation of excited chlorine atoms upon collision with CF2Cl2, H2, D2, Cl2, O2, and inert gases are estimated. 7 references.

  7. Adaptive Routing Algorithms in Unstructured Peer-to-Peer (P2P Systems

    Achmad Nizar Hidayanto,

    2011-02-01

    Full Text Available There are a variety of peer-to-peer (P2P systems for sharing documents currently available. According to their data organization, P2P systems are classified into two categories: structured andunstructured P2P systems. In structured P2P systems, peers are organized according to some mapping techniques, e.g. hashing function. Whereas in unstructured P2P system, peers are connected to each others randomly; resources are not moved to other peers but hosted on site. Unstructured P2P systems offer a more flexible and autonomous environment, as they require less control for the placement of resources and peers. This work focuses on experimenting on unstructured P2P systems. The challenge in unstructured P2P system is designing routing strategies that lead the user in finding the documents needed. Routing strategies in unstructured P2P system need to consider the dynamic aspects of P2P systems; peers are dynamic and constantly joining and leaving the system, network load changescontinuously and resources are added and removed over the time. Therefore, the routing strategy must adapt to such changes to maintain its performance. We propose routing strategies that adapt to these changes through learning mechanisms. The learning mechanisms are conducted by observing the internal and external behaviors of the system. Internal behaviors reflect the internal state of peers such as peers’ interest and collection. External behaviors reflect the external state of the system such as network load. In order to measure the performance of the proposed routing algorithms, some common performance measurements are used. These are “response time” and “number of messages generated” or what is commonly referred to as efficiency, “number of answered and satisfied queries” and the “similarity of documents” or what is commonly referred to as effectiveness of retrieval system. The experiment results show that the proposed algorithms are capable of adapting to

  8. An Efficient, Scalable and Robust P2P Overlay for Autonomic Communication

    Li, Deng; Liu, Hui; Vasilakos, Athanasios

    The term Autonomic Communication (AC) refers to self-managing systems which are capable of supporting self-configuration, self-healing and self-optimization. However, information reflection and collection, lack of centralized control, non-cooperation and so on are just some of the challenges within AC systems. Since many self-* properties (e.g. selfconfiguration, self-optimization, self-healing, and self-protecting) are achieved by a group of autonomous entities that coordinate in a peer-to-peer (P2P) fashion, it has opened the door to migrating research techniques from P2P systems. P2P's meaning can be better understood with a set of key characteristics similar to AC: Decentralized organization, Self-organizing nature (i.e. adaptability), Resource sharing and aggregation, and Fault-tolerance. However, not all P2P systems are compatible with AC. Unstructured systems are designed more specifically than structured systems for the heterogeneous Internet environment, where the nodes' persistence and availability are not guaranteed. Motivated by the challenges in AC and based on comprehensive analysis of popular P2P applications, three correlative standards for evaluating the compatibility of a P2P system with AC are presented in this chapter. According to these standards, a novel Efficient, Scalable and Robust (ESR) P2P overlay is proposed. Differing from current structured and unstructured, or meshed and tree-like P2P overlay, the ESR is a whole new three dimensional structure to improve the efficiency of routing, while information exchanges take in immediate neighbors with local information to make the system scalable and fault-tolerant. Furthermore, rather than a complex game theory or incentive mechanism, asimple but effective punish mechanism has been presented based on a new ID structure which can guarantee the continuity of each node's record in order to discourage negative behavior on an autonomous environment as AC.

  9. P2P Networks: The interplay between legislation and information technology

    Wong, Sulan; Altman, Eitan; Ibrahim, Mouhamad

    2009-01-01

    P2P has become a major part of Internet traffic. Along with a growing economic e-commerce activity in which consumers purchase music, video, software and books over the Internet, P2P file sharing networks have enabled a free widespread public access to copyrighted material. A long lasting conflict accompanied by an impressive ``arms race'' has been developing between ``producers'' (i.e. copyright owner companies) and ``users'' (part of the web surfers community). In their effort to decrease i...

  10. Enabling Co-located Learning over Mobile Ad Hoc P2P with LightPeers

    Bent Guldbjerg Christensen; Mads Darø Kristensen; Frank Allan Hansen; Niels Olof Bouvin

    2008-01-01

    This paper presents LightPeers – a new mobile P2P framework specifically tailored for use in a nomadic learning environment. A set of key requirements for the framework is identified based on nomadic learning, and these requirements are used as outset for designing and implementing the architecture and protocols. The main contributions of the LightPeers framework are: a mobile P2P framework including a specialized robust messaging protocol resilient to changes in the network topology, an deve...

  11. Altered expression of two-pore domain potassium (K2P) channels in cancer

    Williams, Sarah; Bateman, Andrew; O'Kelly, Ita

    2013-01-01

    Potassium channels have become a focus in cancer biology as they play roles in cell behaviours associated with cancer progression, including proliferation, migration and apoptosis. Two-pore domain (K2P) potassium channels are background channels which enable the leak of potassium ions from cells. As these channels are open at rest they have a profound effect on cellular membrane potential and subsequently the electrical activity and behaviour of cells in which they are expressed. The K2P fami...

  12. Quantum Cohomology of Hilb^2(P^1xP^1) and Enumerative Applications

    Pontoni, Dalide

    2004-01-01

    We compute the Small Quantum Cohomology of Hilb^2(P^1xP^1) and determine recursively most of the Big Quantum Cohomology. We prove a relationship between the invariants so obtained and the enumerative geometry of hyperelliptic curves in P^1xP^1. This extends the results obtained by Graber for Hilb^2(P^2) and hyperelliptic curves in P^2.

  13. Database Selection and Result Merging in P2P Web Search

    Chernov, Sergey; Serdyukov, Pavel; Bender, Matthias; Michel, Sebastian; Weikum, Gerhard; Zimmer, Christian; Bergamaschi, Sonia; Moro, Gianluca; Ouksel, Aris M.

    2006-01-01

    Intelligent Web search engines are extremely popular now. Currently, only the commercial centralized search engines like Google can process terabytes of Web data. Alternative search engines fulfilling collaborative Web search on a voluntary basis are usually based on a blooming Peer-to-Peer (P2P) technology. In this paper, we investigate the effectiveness of different database selection and result merging methods in the scope of P2P Web search engine Minerva. We adapt ...

  14. Database Selection and Result Merging in P2P Web Search

    Chernov, Sergey; Serdyukov, Pavel; Bender, Matthias; Michel, Sebastian; Weikum, Gerhard; Zimmer, Christian

    2007-01-01

    Intelligent Web search engines are extremely popular now. Currently, only the commercial centralized search engines like Google can process terabytes of Web data. Alternative search engines fulfilling collaborative Web search on a voluntary basis are usually based on a blooming Peer-to-Peer (P2P) technology. In this paper, we investigate the effectiveness of different database selection and result merging methods in the scope of P2P Web search engine Minerva. We adapt ...

  15. A Group-oriented Access Control Scheme for P2P Networks

    Wang Xiaoming; Cheng Fan

    2011-01-01

    A group-oriented access control scheme is proposed for P2P (peer to peer) networks. In the proposed scheme, authentication control, admission control and revocation control are used in order to provide security services for P2P networks. Moreover, the proposed scheme can simply and efficient establish share key between two members without interactions, therefore it can perform secure communications with them. The analysis of security and performance shows that the proposed scheme not only can...

  16. Spin structure of binary processes in the 3P0 model of coloured tube

    The binary processes 0+1/2 →0+1/2 (π-p → π0n, π-p → ηn) are considered in the coloured tube model. It is shown that the relations of residues of the amplitude M0+iσ-vectorn-vectorq/2q0M1 and their q2-dependence at the secondary Regge pole exchange is determined by the wave function of a gg-bar pair which appears in the 3P0 state at disruption of a coloured tube. The account of the Thomas interaction gives a small contribution into matrix elements logarithmically decreasing with energy. The model, accounting for absorption, agrees semiquantitatively with experimental data

  17. Product lambda-doublet ratios for the O(3P) + D2 reaction: A mechanistic imprint

    Jambrina, P G; Aldegunde, J; Brouard, M; Aoiz, F J

    2016-01-01

    In the last decade, the development of theoretical methods have allowed chemists to reproduce and explain almost all of the experimental data associated with elementary atom plus diatom collisions. However, there are still a few examples where theory cannot account yet for experimental results. This is the case for the preferential population of one of the $\\Lambda$-doublet states produced by chemical reactions. In particular, recent measurements of the OD($^2\\Pi$) product of the O($^3$P) + D$_2$ reaction have shown a clear preference for the $\\Pi(A')$ $\\Lambda$-doublet states, in apparent contradiction with {\\em ab initio} calculations, which predict a larger reactivity on the $A"$ potential energy surface. Here we present a method to calculate the $\\Lambda$-doublet ratio when concurrent potential energy surfaces participate in the reaction. It accounts for the experimental $\\Lambda$-doublet populations via explicit consideration of the stereodynamics of the process. Furthermore, our results demonstrate that...

  18. Lanthanide refractory semiconductors based on the Th/sub 3/P/sub 4/ structure

    The phase relationships and the important structural, electrical and thermal properties of the R/sub 3/X/sub 4/-R/sub 2/X/sub 3/ (where R = lanthanides and X = S, Se and Te) phases having the Th/sub 3/P/sub 4/-type structure are reviewed. The room temperature electrical resistivity and Seebeck coefficient of these materials are independent of R and only slightly dependent on X, but critically dependent on the X:R ratio. The long term stability of these phases is also reviewed. Although these materials have good thermoelectric properties there are some problems which need to be solved before these phases can be utilized in thermoelectric devices. These problems include long term stability, higher than desirable thermal conductivities, and low electron mobilities

  19. Mechanisms and Kinetics of Radical Reaction of O(1D,3P) + HCN System

    HUANG Yu-Cheng; DU Jin-Yan; JU Xue-Hai; YE Shi-Yong; ZHOU Tao

    2008-01-01

    The reaction of HCN with O(1D, 3P) radical has been investigated by density functional theory (DFT) and ab initio methods. The stationary points on the reaction paths(reactants, intermediates and products) were optimized at the (U)B3LYP/aug-cc-pVTZ level.Single-point calculations were performed at the (U)QCISD(T)/aug-cc-pVTZ level for the optimized structures and all the total energies were corrected by zero-point energy. It is shown that there exist three competing mechanisms of oxygen attacking nitrogen O→N, oxygen attacking carbon O→C and oxygen attacking hydrogen O→H. The rate constants were obtained via Eyring transition-state theory in the temperature range of 600~2000 K. The linear relationship between lnk and 1/T was presented. The results show that path 1 is the main reaction channel and the product of NCO + H is predominant.

  20. High strength Al–Al2O3p composites: Optimization of extrusion parameters

    Luan, B.F.; Hansen, Niels; Godfrey, A.;

    2011-01-01

    Composite aluminium alloys reinforced with Al2O3p particles have been produced by squeeze casting followed by hot extrusion and a precipitation hardening treatment. Good mechanical properties can be achieved, and in this paper we describe an optimization of the key processing parameters. The...... investigation of their mechanical properties and microstructure, as well as on the surface quality of the extruded samples. The evaluation shows that material with good strength, though with limited ductility, can be reliably obtained using a production route of squeeze casting, followed by hot extrusion and a...... precipitation hardening treatment. For the extrusion step optimized processing parameters have been determined as: (i) extrusion temperature=500°C–560°C; (ii) extrusion rate=5mm/s; (iii) extrusion ratio=10:1....

  1. Precision Hyperfine Structure of 2;^3P State of ^3He with External Magnetic

    Wu, Qixue; Drake, G. W. F.

    2007-06-01

    The theory of the Zeeman effect can be used to extrapolate precise measurements for the fine structure or the hyperfine structure to zero-field strength. In the present work, the hyperfine structure of 2;^3P state of ^3He with external magnetic fields is precisely calculated. The values of the fields for 32 crossings and five anticrossings of the magnetic sublevels are theoretically predicted for magnetic field strengths up to 1 Tesla. The results are compared with experimental work. We include the linear terms, diamagnetic terms, and the 2̂ relativistic correction terms in the Zeeman Hamiltonian. All related matrix elements are calculated with high accuracy by the use of double basis set Hylleraas type variational wave functions[1,2].[1] Z. -C. Yan and G.W.F. Drake, Phys. Rev. A 50, R1980 (1994).[2] Q. Wu and G.W.F. Drake, J. Phys. B 40, 393 (2007).

  2. Spectral Investigation of Crystalline (CuHPO4, Cu2P4O12, and Cu2P8O22 and Glassy Copper Phosphates

    Christiane Günther

    2013-01-01

    Full Text Available Emerald green crystals of the new composition CuHPO4 were synthesized and compared to (copper metaphosphate Cu2P4O12 and (copper ultraphosphate Cu2P8O22. Various copper ultraphosphate and metaphosphate glasses of different compositions between pure P2O5 and Cu2P4O12 were melted in crucibles or in evacuated and sealed silica ampoules at 1473 K or 1373 K for 2 hrs. The UV-VIS-spectra and the IR-spectra of all crystals and glasses were measured and compared. The absorption band of Cu2+ was resolved into more component Gaussian bands and differentiated between square-pyramidal and octahedrally coordinated copper. These structural changes are responsible for colour changes from green to turquoise. The infrared spectroscopic properties of the copper phosphate glasses differ between metaphosphate and ultraphosphate structures but show similarities between the crystals and the glasses of the same structure type. EPR studies of some of the glasses show different kinds of spectra, with increasing copper content.

  3. The impact of playout policy on the performance of P2P live streaming: or how not to kill your P2P advantage

    Vassilakis, Constantinos; Laoutaris, Nikolaos; Stavrakakis, Ioannis

    2008-01-01

    In this paper we examine the impact of the adopted playout policy on the performance of P2P live streaming systems. We argue and demonstrate experimentally that (popular) playout policies which permit the divergence of the playout points of different nodes can deteriorate drastically the performance of P2P live streaming. Consequently, we argue in favor of keeping different playout points "near-in-time", even if this requires sacrificing (dropping) some late frames that could otherwise be rendered (assuming no strict bidirectional interactivity requirements are in place). Such nearly synchronized playout policies create "positive correlation" with respect to the available frames at different playout buffers. Therefore, they increase the number of upstream relay nodes from which a node can pull frames and thus boost the playout quality of both single-parent (tree) and multiple-parent (mesh) systems. On the contrary, diverging playout points reduce the number of upstream parents that can offer a gapless relay of the stream. This is clearly undesirable and should be avoided as it contradicts the fundamental philosophy of P2P systems which is to supplement an original service point with as many additional ones presented by the very own users of the service.

  4. Data transport and management in P2P Data Management in Mobile Wireless Sensor Network

    The rapid growth in wireless technologies has made wireless communication an important source for transporting data across different domains. In the same way, there are possibilities of many potential applications that can be deployed using WSNs (Wireless Sensor Networks). However, very limited applications are deployed in real life due to the uncertainty and dynamics of the environment and scare resources. This makes data management in WSN a challenging area to find an approach that suits its characteristics. Currently, the trend is to find efficient data management schemes using evolving technologies, i.e. P2P (Peer-to-Peer) systems. Many P2P approaches have been applied in WSNs to carry out the data management due to similarities between WSN and P2P. With the similarities, there are differences too that makes P2P protocols inefficient in WSNs. Furthermore, to increase the efficiency and to exploit the delay tolerant nature of WSNs, where ever possible, the mobile WSNs are gaining importance. Thus, creating a three dimensional problem space to consider, i.e. mobility, WSNs and P2P. In this paper, an efficient algorithm is proposed for data management using P2P techniques for mobile WSNs. The real world implementation and deployment of proposed algorithm is also presented. (author)

  5. P2P network traffic control mechanism based on global evaluation values

    XU Xiao-long; WANG Ru-chuan

    2009-01-01

    Peer-to-peer (P2P) computing technology has been widely used on the Internet to exchange data. However, it occupies much network bandwidth, and thus greatly influences traditional business on the Interact. Besides, problems about free-riders and 'tragedy of the commons' in the P2P environment estrange from it P2P users who constantly contribute to the network with quality resources. This article proposes a new P2P network traffic control mechanism based on global evaluation values. It aims to help individual users to avoid peak traffic time as much as possible, ease network congestion and protect traditional business on the Interact, as well as differentiating priority grades of peers according to their contributions and stimulating them to share their valuable resources actively. This article first analyzes the current state of network traffic, and then elaborates on P2P network traffic control policies and proposes the peer's priority level differentiation mechanism based on global evaluation values. Finally,after the testing results and analysis of the proposed P2P network traffic control mechanism are discussed, conclusions are drawn.

  6. P2P-based botnets: structural analysis, monitoring, and mitigation

    Yan, Guanhua [Los Alamos National Laboratory; Eidenbenz, Stephan [Los Alamos National Laboratory; Ha, Duc T [UNIV AT BUFFALO; Ngo, Hung Q [UNIV AT BUFFALO

    2008-01-01

    Botnets, which are networks of compromised machines that are controlled by one or a group of attackers, have emerged as one of the most serious security threats on the Internet. With an army of bots at the scale of tens of thousands of hosts or even as large as 1.5 million PCs, the computational power of botnets can be leveraged to launch large-scale DDoS (Distributed Denial of Service) attacks, sending spamming emails, stealing identities and financial information, etc. As detection and mitigation techniques against botnets have been stepped up in recent years, attackers are also constantly improving their strategies to operate these botnets. The first generation of botnets typically employ IRC (Internet Relay Chat) channels as their command and control (C&C) centers. Though simple and easy to deploy, the centralized C&C mechanism of such botnets has made them prone to being detected and disabled. Against this backdrop, peer-to-peer (P2P) based botnets have emerged as a new generation of botnets which can conceal their C&C communication. Recently, P2P networks have emerged as a covert communication platform for malicious programs known as bots. As popular distributed systems, they allow bots to communicate easily while protecting the botmaster from being discovered. Existing work on P2P-based hotnets mainly focuses on measurement of botnet sizes. In this work, through simulation, we study extensively the structure of P2P networks running Kademlia, one of a few widely used P2P protocols in practice. Our simulation testbed incorporates the actual code of a real Kademlia client software to achieve great realism, and distributed event-driven simulation techniques to achieve high scalability. Using this testbed, we analyze the scaling, reachability, clustering, and centrality properties of P2P-based botnets from a graph-theoretical perspective. We further demonstrate experimentally and theoretically that monitoring bot activities in a P2P network is difficult

  7. Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.

    Gu, Nan; You, Lianghui; Shi, Chunmei; Yang, Lei; Pang, Lingxia; Cui, Xianwei; Ji, Chenbo; Zheng, Wen; Guo, Xirong

    2016-08-01

    Obesity is associated with a notable risk for disease, including risk of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension. Adipose tissue modulates the metabolism by releasing free fatty acids (FFAs) and adipokines, including leptin, resistin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL‑6). Altered secretion patterns of FFAs and adipokines have been demonstrated to result in obesity‑associated insulin resistance (IR) and inflammatory responses. MicroRNA-199a-3p (miR)-199a-3p expression is significantly induced in differentiated human adipose-derived mesenchymal stem cells and indicates the association with T2DM. However, the association between miR-199a-3p levels in adipocytes and obesity‑associated IR, as well as inflammatory responses remains to be elucidated. The present study observed an elevation of miR‑199a‑3p expression level in mature human adipocytes (visceral) compared with pre-adipocytes. In addition, miR‑199a‑3p expression was higher in visceral adipose deposits from obese subjects. FFA, TNF-α, IL‑6 and leptin significantly induced miR‑199a‑3p expression in mature human adipocytes, while resistin had the opposite effect. miR‑199a‑3p may represent a factor in the modulation of obesity‑associated IR and inflammatory responses. PMID:27279151

  8. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200.

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  9. MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes.

    Kang, Liang; Yang, Cao; Song, Yu; Liu, Wei; Wang, Kun; Li, Shuai; Zhang, Yukun

    2016-09-01

    Osteoarthritis (OA) is a common chronic degenerative joint disease. Progressive destruction of the integrity of articular cartilage is an important pathological feature, but treatment options that reverse this damage have not been developed. According to recent studies, microRNAs have important regulatory roles in the initiation and progression of OA. In the current study, the biological effects of miR-23a-3p and its expression in OA tissues were examined. We found that miR-23a-3p expression was obviously higher and SMAD3 expression was significantly lower in OA cartilage than in normal tissues. The hypomethylation status of CpG islands in the promoter region of miR-23a-3p was confirmed by methylation-specific polymerase chain reaction in OA cartilage tissues. Furthermore, a bioinformatics analysis and luciferase reporter assay identified SMAD3 as a target gene of miR-23a-3p and SMAD3 expression at both the protein and mRNA levels was inhibited by miR-23a-3p. A functional analysis demonstrated that miR-23a-3p overexpression suppresses type II collagen and aggrecan expression, while miR-23a-3p inhibition had the opposite effects. Small interfering RNA-mediated knockdown of SMAD3 reversed the effects of the miR-23a-3p inhibitor on the expression of type II collagen and aggrecan. Our results suggested that miR-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment. PMID:27318087

  10. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells

  11. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping, E-mail: bieping2010@163.com

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  12. Hyperfine Quenching of the $4s4p ^{3}P_{0}$ Level in Zn-like Ions

    Marques, J P; Indelicato, Paul

    2007-01-01

    In this paper, we used the multiconfiguration Dirac-Fock method to compute with high precision the influence of the hyperfine interaction on the $[Ar]3d^{10} 4s4p ^3P_0$ level lifetime in Zn-like ions for stable and some quasi-stable isotopes of nonzero nuclear spin between Z=30 and Z=92. The influence of this interaction on the $[Ar]3d^{10} 4s4p ^3P_1 - [Ar]3d^{10} 4s4p ^3P_0$ separation energy is also calculated for the same ions.

  13. Energy-band alignment of II-VI/Zn3P2 heterojunctions from x-ray photoemission spectroscopy

    Watson, Graeme

    2013-01-01

    PUBLISHED The energy-band alignments for zb-ZnSe(001)/ a -Zn 3 P 2 (001), w-CdS(0001)/ a -Zn 3 P 2 (001), and w-ZnO(0001)/ a -Zn 3 P 2 (001) heterojunctions have been determined using high-resolution x-ray photoelectron spectroscopy via the Kraut method. Ab initio hybrid density functional theory calculations of the valence-band density of states were used to determine the energy differences between the core level and ...

  14. Wakefield Computations for the CLIC PETS using the Parallel Finite Element Time-Domain Code T3P

    Candel, A; Kabel, A.; Lee, L.; Li, Z.; Ng, C.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; /CERN

    2009-06-19

    In recent years, SLAC's Advanced Computations Department (ACD) has developed the high-performance parallel 3D electromagnetic time-domain code, T3P, for simulations of wakefields and transients in complex accelerator structures. T3P is based on advanced higher-order Finite Element methods on unstructured grids with quadratic surface approximation. Optimized for large-scale parallel processing on leadership supercomputing facilities, T3P allows simulations of realistic 3D structures with unprecedented accuracy, aiding the design of the next generation of accelerator facilities. Applications to the Compact Linear Collider (CLIC) Power Extraction and Transfer Structure (PETS) are presented.

  15. Theoretical Stark widths and shifts of spectral lines of 2p5nf and 2p55g configurations of Mg III

    Moreno-Díaz, Cristina; Alonso-Medina, Aurelia; Colón, Cristóbal

    2014-11-01

    In this paper, we report theoretical Stark widths and shifts calculated using the Griem semi-empirical approach, which corresponds to 111 spectral lines of Mg III. The values of these Stark broadening parameters of spectral lines that arise from levels of 2p5nf and 2p55g configurations of Mg III are presented in the literature for the first time. The aim of this work is to provide values to estimate the electron density of plasma Mg III in astrophysics and industrial applications. The data are presented for the temperatures T = 0.5-10.0 (104 K) and for an electron density of 1017 cm-3. The matrix of elements used in these calculations has been determined from 23 configurations of Mg III: 2s22p6, 2s22p53p, 2s22p54p, 2s22p54f and 2s22p55f for the even parity and 2s22p5ns (n = 3-6), 2s22p5nd (n = 3-9), 2s22p55g and 2s2p6np (n = 3-8) for the odd parity. For the intermediate coupling calculations, we use the standard method of least square fitting from experimental energy levels by means of Cowan’s computer code. Lines with wavelengths of 134.6460, 135.2800, 189.0380, 190.0043, 192.8424, 408.2939 and 409.4375 nm have high probabilities and also have high values of broadening. Therefore, these lines can be used in some applications. A common regularity for the Stark width of the 189.038 nm spectral line of Mg III is discussed.

  16. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Adrian, M. L.; Gallagher, D.; Craven, P.; Tomlinson, W.; Cravens, J.; Burch, J.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km per second with a low-power requirement of approx. 1 kW per 100 kg of payload and approx. 1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km per second solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs, Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  17. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

    Schewe, Marcus; Nematian-Ardestani, Ehsan; Sun, Han; Musinszki, Marianne; Cordeiro, Sönke; Bucci, Giovanna; de Groot, Bert L; Tucker, Stephen J; Rapedius, Markus; Baukrowitz, Thomas

    2016-02-25

    Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. Overall, this ion-flux gating mechanism generates a one-way "check valve" within the filter because outward movement of K(+) induces filter opening, whereas inward movement promotes inactivation. Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels into a leak conductance. These findings provide insight into the functional plasticity of a K(+)-selective filter and also refine our understanding of K2P channels and the mechanisms by which ion channels can sense voltage. PMID:26919430

  18. 2P/Encke, the Taurid complex NEOs and the Maribo and Sutter's Mill meteorites

    Tubiana, C; Michelsen, R; Haack, H; Boehnhardt, H; Fitzsimmons, A; Williams, I P

    2015-01-01

    The Taurid meteoroid stream has long been linked with 2P/Encke owing to a good match of their orbital elements, even though the comet's activity is not strong enough to explain the number of observed meteors. Various small NEOs have been discovered with orbits that can be linked to 2P and the Taurid meteoroid stream. Maribo and Sutter's Mill are CM type carbonaceous chondrites that fell in Denmark on Jan 17, 2009 and Apr 22, 2012, respectively. Their pre-atmospheric orbits place them in the middle of the Taurid meteoroid stream, which raises the intriguing possibility that comet 2P could be the parent body of CM chondrites. To investigate whether a relationship between comet 2P, the Taurid complex associated NEOs, and CM chondrites exists, we performed photometric and spectroscopic studies of these objects in the visible wavelength range. We observed 2P and 10 NEOs on Aug 2, 2011 with FORS at the VLT. Images in the R filter, used to investigate the possible presence of cometary activity around the nucleus of ...

  19. P2P Streaming Traffic Classification in High-Speed Networks

    Chen Luying; Cong Rong; Yang Jie; Yu Hua

    2011-01-01

    The growing P2P streaming traffic brings a variety of problems and challenges to ISP networks and service providers.A P2P streaming traffic classification method based on sampling technology is presented in this paper.By analyzing traffic statistical features and network behavior of P2P streaming,a group of flow characteristics were found,which can make P2P streaming more recognizable among other applications.Attributes from Netflow and those proposed by us are compared in terms of classification accuracy,and so are the results of different sampling rates.It is proved that the unified classification model with the proposed attributes can identify P2P streaming quickly and efficiently in the online system.Even with 1∶50 sampling rate,the recognition accuracy can be higher than 94%.Moreover,we have evaluated the CPU resources,storage capacity and time consumption before and after the sampling,it is shown that the classification model after the sampling can significantly reduce the resource requirements with the same recognition accuracy.

  20. An Efficient Architecture for Information Retrieval in P2P Context Using Hypergraph

    Ismail, Anis; Durand, Nicolas; Hajjar, Mohammad

    2011-01-01

    Peer-to-peer (P2P) Data-sharing systems now generate a significant portion of Internet traffic. P2P systems have emerged as an accepted way to share enormous volumes of data. Needs for widely distributed information systems supporting virtual organizations have given rise to a new category of P2P systems called schema-based. In such systems each peer is a database management system in itself, ex-posing its own schema. In such a setting, the main objective is the efficient search across peer databases by processing each incoming query without overly consuming bandwidth. The usability of these systems depends on successful techniques to find and retrieve data; however, efficient and effective routing of content-based queries is an emerging problem in P2P networks. This work was attended as an attempt to motivate the use of mining algorithms in the P2P context may improve the significantly the efficiency of such methods. Our proposed method based respectively on combination of clustering with hypergraphs. We use...

  1. Information Exchange rather than Topology Awareness: Cooperation between P2P Overlay and Traffic Engineering

    Jia Zhao

    2014-01-01

    Full Text Available Solutions to the routing strategic conflict between noncooperative P2P overlay and ISP underlay go separate ways: hyperselfishness and cooperation. Unpredictable (possibly adverse impact of the hyperselfish topology awareness, which is adopted in both overlay routing and traffic engineering, has not been sufficiently studied in the literature. Topology-related information exchange in a cooperatively efficient way should be highlighted to alleviate the cross-layer conflict. In this paper, we first illustrate the hyperselfish weakness with two dynamic noncooperative game models in which hyperselfish overlay or underlay has to accept a suboptimal profit. Then we build a synergistic cost-saving (SC game model to reduce the negative effects of noncooperation. In the SC model, through information exchange, that is, the classified path-delay metrics for P2P overlay and peer locations for underlay, P2P overlay selects proximity as well as saving traffic transit cost for underlay, and ISP underlay adjusts routing to optimize network cost as well as indicating short delay paths for P2P. Simulations based on the real and generated topologies validate cost improvement by SC model and find a proper remote threshold value to limit P2P traffic from remote area, cross-AS, or cross-ISP.

  2. RESEARCH ON GROUPING STRATEGY OF SIP-BASED STREAMING MEDIA P2P LIVE BROADCAST NETWORK

    Liu Hui; Huang Yongfeng; Li Xing

    2008-01-01

    The rapid development of Internet has led to the explosion of information sharing, and how to supervise the sharing is a main research topic on current Internet. Aiming at the disadvantage that the current Peer-to-Peer (P2P) is hard to manage and control, this paper presents a Session Initial Protocol (SIP)-based P2P network of three-level architecture. SIP middleware is introduced to the middle level of the three-layer architecture. By the connection function of the SIP signaling, the P2P transmission on media-level can be controlled. Using SIP's register and authentication function, the manage layer can manage the whole P2P network. Based on the aforementioned architecture, this paper investigates the grouping strategy on a live broadcast application in P2P network. Combined with the function of SIP register, the paper works on several grouping strategies, sets up models to manage users by grouping them, presents a weight-based K-means IP address grouping algorithm, and realizes it. The experiment shows that the grouping strategy presented in this paper can solve the problem of group sharing of network resource, and can realize the efficient-sharing, reasonable-distributing of network resource.

  3. 基于Super Peer的P2P e-Learning模型%New P2P e-Learning model based on Super Peer

    陈金儿; 王让定

    2007-01-01

    在分析各种P2P网络特点的基础上,提出了分布式环境中基于超节点的P2P e-Learning模型.对特定peer组中超节点的加入和超节点的服务进行了具体描述.针对e-Learning的特性,给出了模型中的数据抽象和本体描述,并对该P2P网络模型在文件传输方面的性能做了分析.

  4. Distributed Peer Discovery in Large-Scale P2P Streaming Systems : Addressing Practical Problems of P2P Deployments on the Open Internet

    Jimenez, Raul

    2013-01-01

    Peer-to-peer (P2P) techniques allow users with limited resources to distribute content to a potentially large audience by turning passive clients into peers. Peers can self-organize to distribute content to each other, increasing the scalability of the system and decreasing the publisher’s costs, compared to a publisher distributing the data himself using a content delivery network (CDN) or his own servers. Peer discovery is the mechanism that peers use to find each other. Peer discovery is a...

  5. Research of the lime rich portions of the CaO-SiO2-P2O5 system

    Puertas, F.

    1995-03-01

    Full Text Available A detailed study has been carried out to explain the influence of Pp^ in silicate phases and in industrial raw meals upon their mineralogical compositions. Some compositions in the lime rich portion of the CaO-SiO2-P2O5 system are studied using laboratory reactants. The results showed that the compositions lying in the range of CaO = 69,5-70,1; P2O5= 16,2-19,5; SiO2 = 11,1-13,6 (wt% give, at 1000 °C, the mineralogical composition (HAp, β-C2S, C5PS which can develop a high strength in chemically bonded ceramics. At high temperature (1400 ºC these compositions give a large amount of silicocarnotite (C5PS and 2C2.C3P phase. A selected composition of the industrial raw meal with added phosphate: CaO = 62,66; SiO2 -= 17,33; Al2O3 = 4,88; Fe2O3 = 4,29; P2O5 = 8,73; MgO = 2,09 (wt% forms at 1350 ºC a clinker containing high amount of α-C2S to replace C3S. Such a clinker may have good applications in the synthesis of active belite cement.Se estudia con detalle la influencia del P2O5 sobre las composiciones mineralógicas en fases silicato y en un crudo industrial. Asimismo se estudian algunas composiciones de la zona rica en cal del sistema CaO-SiO2-P2O5 utilizando reactivos químicos. Los resultados demuestran que, a presión atmosférica y recinto abierto, las composiciones dentro de los límites CaO = 69,5-70,1; P2O5= 16,2-19,5; SiO2 = 11,1-13,6 (% en peso dan a 1000ºC la composición mineralógica siguiente: HAp, β-C2S, C5PS; pueden desarrollar una alta resistencia química en "chemically bonded ceramics". A altas temperaturas (1400°C producen una elevada proporción de silicocarnotita (C5PS S y la fase 2C2.C3P. Con la adición de fosfato a una determinada dosificación de crudo industrial (CaO = 62,66; SiO2 = 17,33; Al2O3 = 4,88; Fe2O3 = 4,29; P2O5 = 8,73; MgO = 2,09 -% en peso- se forma, a 1350°C, un clinker que contiene una alta proporción de α-C2S que reemplaza al C3S. Este clinker puede tener buenas aplicaciones en la obtención de

  6. Join the CERN ISEF special award winners | 16 June - 3 p.m.

    2016-01-01

    Come and join the CERN ISEF special award winners at their lightning talks session on 16 June at 3.00 p.m. in the main auditorium.   The 2016 Intel ISEF CERN special award winners on stage with the selection committee on 17 May 2016 in Phoenix, Arizona, USA. (Picture: Society for Science and the Public) Between 11 and 17 June 2016, the ten finalists of the Intel International Science and Engineering Fair (ISEF) who won the CERN Special Award, will visit CERN to partake in various educational lectures. ISEF is the world's largest international pre-college science competition, with approximately 1,700 high school students from more than 75 countries taking part. They will present their projects in short 5 minutes lightning talks' sessions at the main auditorium on Thursday 16 June at 3 p.m. The award winners would be also very happy to have a chance to interact and discuss with you af...

  7. Half-quantized Non-Abelian Vortices in Neutron $^3P_2$ Superfluids inside Magnetars

    Masuda, Kota

    2016-01-01

    We point out that half-quantized non-Abelian vortices exist as the minimum energy states in rotating neutron $^3P_2$ superfluids in the inner cores of magnetars with magnetic field greater than $3 \\times 10^{15}$ Gauss, while they do not in ordinary neutron stars with smaller magnetic fields. One integer vortex is split into two half-quantized vortices. The number of vortices is about $10^{19}$ and they are separated at about $\\mu$m in a vortex lattice for typical parameters, while the vortex core size is about 10-100 fm. They are non-Abelian vortices characterized by non-Abelian first homotopy group, and consequently when two vortices corresponding to non-commutative elements collide, a rung vortex must be created between them, implying the formation of an entangled vortex network inside the cores of magnetars. We find the spontaneous magnetization in the vortex core showing anti-ferromagnetism whose typical magnitude is about $10^{8-9}$ Gauss that is ten times larger than that of integer vortices, when exte...

  8. ACE3P Computations of Wakefield Coupling in the CLIC Two-Beam Accelerator

    Candel, Arno; Li, Z.; Ng, C.; Rawat, V.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; Grudiev, A.; Wuensch, W.; /CERN

    2010-10-27

    The Compact Linear Collider (CLIC) provides a path to a multi-TeV accelerator to explore the energy frontier of High Energy Physics. Its novel two-beam accelerator concept envisions rf power transfer to the accelerating structures from a separate high-current decelerator beam line consisting of power extraction and transfer structures (PETS). It is critical to numerically verify the fundamental and higher-order mode properties in and between the two beam lines with high accuracy and confidence. To solve these large-scale problems, SLAC's parallel finite element electromagnetic code suite ACE3P is employed. Using curvilinear conformal meshes and higher-order finite element vector basis functions, unprecedented accuracy and computational efficiency are achieved, enabling high-fidelity modeling of complex detuned structures such as the CLIC TD24 accelerating structure. In this paper, time-domain simulations of wakefield coupling effects in the combined system of PETS and the TD24 structures are presented. The results will help to identify potential issues and provide new insights on the design, leading to further improvements on the novel CLIC two-beam accelerator scheme.

  9. Utilising the `3P-model' to Characterise the Discipline of Didactics of Science

    Adúriz-Bravo, Agustín; Izquierdo-Aymerich, Mercè

    In our research within didactics of science, we have been exploring contributions of the so called cognitive models from contemporary philosophy of science. We have used these philosophical frameworks on different levels. As an outcome, we have formulated a model of didactics of science according to which this discipline adapts and transforms theoretical contributions from different scholarly fields. In this paper, we concentrate on this description of didactics of science, which we have called the 3P-model (i.e., philosophy + psychology + pedagogy). This model of the internal functioning of the discipline may be useful to make innovations in science curriculum design and re-conceptualise the role of science teachers as professionals. We see didactics of science as a set of interrelated activities, performed by different individuals, and ranging from theoretical production to practice of science education at school. We find the concept of technoscience suitable to account for this diversity of goals. According to this concept, scientific disciplines are identified both with generation of knowledge and with active intervention on the world. Within current didactics of science, we recognise several kinds of research, having goals more or less directed to practical intervention in science education.

  10. Precision frequency measurement of 1S0–3P1 intercombination lines of Sr isotopes

    We report on frequency measurement of the intercombination (5s2)1S0–(5s5p)3P1 transition of the four natural isotopes of strontium, including 88Sr (82.58%), 87Sr (7.0%), 86Sr (9.86%), and 84Sr (0.56%). A narrow-linewidth laser that is locked to an ultra-low expansion (ULE) optical cavity with a finesse of 12000 is evaluated at a linewidth of 200 Hz with a fractional frequency drift of 2.8×10−13 at an integration time of 1 s. The fluorescence collector and detector are specially designed, based on a thermal atomic beam. Using a double-pass acousto-optic modulator (AOM) combined with a fiber and laser power stabilization configuration to detune the laser frequency enables high signal-to-noise ratios and precision saturated spectra to be obtained for the six transition lines, which allows us to determine the transition frequency precisely. The optical frequency is measured using an optical frequency synthesizer referenced to an H maser. Both the statistical values and the final values, including the corrections and uncertainties, are derived for a comparison with the values given in other works. (paper)

  11. miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene.

    Meng, Fang; Qian, Liting; Lv, Lei; Ding, Bojin; Zhou, Gieping; Cheng, Xu; Niu, Sanqiang; Liang, Yu

    2016-04-01

    Chemoradiation therapy is an important component of the curative treatment for oesophageal carcinomas. These therapeutic effects are prevented in patients according to radioresistance and multi-drug resistance, and the cause of such resistance remains unclear. In this study, we identified the role of miR-193a-3p in modulating the radioresistance and chemoresistance of oesophageal cancer cells. We found that KYSE150 and KYSE410 cells could be characterized as relatively radiation-sensitive and radiation-resistant cells, respectively. Similarly, KYSE150 and KYSE410 cells were found to be chemosensitive and chemoresistant, respectively. Over-expression of miR-193a-3p increased the radioresistance and chemoresistance of oesophageal squamous cell carcinoma (ESCC) cells. In contrast, the down-regulation of miR-193a-3p decreased the radioresistance and chemoresistance of ESCC cells. In addition, miR-193a-3p inducing DNA damage has also been demonstrated through measuring the level of gamma-H2AX associated with miR-193a-3p. Moreover, a small interfering RNA(siRNA)-induced repression of the PSEN1 gene had an effect similar to that of miR-193a-3p up-regulation. The above processes also inhibited oesophageal cancer cells apoptosis. These findings suggest that miR-193a-3p contributes to the radiation and chemotherapy resistance of oesophageal carcinoma by down-regulating PSEN1. Thus, miR-193a-3p and PSEN1 might be potential biomarkers for chemoradiation resistant cancers. PMID:26743123

  12. Prm3p Is a Pheromone-induced Peripheral Nuclear Envelope Protein Required for Yeast Nuclear Fusion

    Shen, Shu; Tobery, Cynthia E.; Rose, Mark D.

    2009-01-01

    Nuclear membrane fusion is the last step in the mating pathway of the yeast Saccharomyces cerevisiae. We adapted a bioinformatics approach to identify putative pheromone-induced membrane proteins potentially required for nuclear membrane fusion. One protein, Prm3p, was found to be required for nuclear membrane fusion; disruption of PRM3 caused a strong bilateral defect, in which nuclear congression was completed but fusion did not occur. Prm3p was localized to the nuclear envelope in pheromon...

  13. MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma.

    Deng, Danni; Wang, Lei; Chen, Yao; Li, Bowen; Xue, Lian; Shao, Naiyuan; Wang, Qiang; Xia, Xiwei; Yang, Yilin; Zhi, Feng

    2016-07-01

    The PIM1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and metabolism in various human cancers. MicroRNAs (miRNAs) are powerful post-transcriptional gene regulators that function through translational repression or transcript destabilization. Therefore, we aimed to identify whether a close relationship exists between PIM1 and miRNAs. PIM1 protein levels and mRNA levels were significantly upregulated in astrocytoma tissues, indicating the oncogenic role of PIM1 in astrocytoma. Further bioinformatics analysis indicated that miR-124-3p targeted the 3'-UTR of PIM1. We also observed an inverse correlation between the miR-124-3p levels and PIM1 protein or mRNA levels in astrocytoma samples. Next, we experimentally confirmed that miR-124-3p directly recognizes the 3'-UTR of the PIM1 transcript and regulates PIM1 expression at both the protein and mRNA levels. Furthermore, we examined the biological consequences of miR-124-3p targeting PIM1 in vitro. We showed that the repression of PIM1 in astrocytoma cancer cells by miR-124-3p suppressed proliferation, invasion, and aerobic glycolysis and promoted apoptosis. We observed that the restoration or inhibition of PIM1 activity resulted in effects that were similar to those induced by miR-124-3p inhibitors or mimics in cancer cells. Finally, overexpression of PIM1 rescued the inhibitory effects of miR-124-3p. In summary, these findings aid in understanding the tumor-suppressive role of miR-124-3p in astrocytoma pathogenesis through the inhibition of PIM1 translation. PMID:27088547

  14. Upper bound on the non-colorability threshold of the 2+p-COL problem

    The 2p-COL problem introduced by Walsh, smoothly interpolates between P and NP by mixing together the polynornial 2-coloring problem and the NP complete 3-coloring problem. A natural upper bound on the non colorability of the 2+p-COL problem in min {r-bar2/(1 - p)r-bar3}, where r-bar2 and r-bar3 are the upper bounds on 2-COL and 3-COL thresholds respectively. In this paper we improve this upper-bound for each 0.73 ≤ p 1. This means that for p ≥ 0.73 the 2+p-COL problem does not behave like the 2-COL problem. We use the method developed by Kaporis et al., which combines the concept of legal rigid colorings introduced by Achlioptas and Molloy with the occupancy problem for random allocations of balls into bins. (author)

  15. Analytical Modelling of Localized P2P Streaming Systems under NAT Consideration

    Mohammad Z. M. Masoud

    2013-06-01

    Full Text Available NAT has been design to work with Internet client-server structure. The emerged of Peer-to-Peer (P2Pnetworks and applications revealed the incompatibility between P2P applications and NAT. Many methodshas been developed and implemented to solve connectivity between peers behind NAT devices.Nevertheless, various NATing types can’t communicate with one another. In this work, we are going tostudy the impact of NAT types on the start-up delay time of peers in P2P streaming systems. We willdemonstrate the ability of NATing to expel peers in P2P live streaming systems. A new neighbour selectingalgorithm will be proposed. This algorithm will utilize NAT-types configurations as a parameter. We haveutilized NS2 simulator to show the performance of the new algorithm in increasing the connectivity,reducing the number of expelled peers and implementing of locality.

  16. A P2P Botnet Virus Detection System Based on Data-Mining Algorithms

    Wernhuar Tarng

    2012-11-01

    Full Text Available A P2P botnet virus detection system based on data-mining algorithms is proposed in this study to detect theinfected computers quickly using Bayes Classifier and Neural Network (NN Classifier. The system candetect P2P botnet viruses in the early stage of infection and report to network managers to avoid furtherinfection. The system adopts real-time flow identification techniques to detect traffic flows produced by P2Papplication programs and botnet viruses by comparing with the known flow patterns in the database. Aftertrained by adjusting the system parameters using test samples, the experimental results show that theaccuracy of Bayes Classifier is 95.78% and that of NN Classifier is 98.71% in detecting P2P botnet virusesand suspected flows to achieve the goal of infection control in a short time.

  17. Blokování P2P sítí

    Švajda, Patrik

    2010-01-01

    Tato bakalářská práce se zabývá filtrováním P2P sítí určených k výměně dat. Popisuje vrstvy ISO/OSI modelu, na kterých je možné tyto sítě blokovat. Popisuje nástroje detekující P2P sítě na základě datové části paketu určeného pro operační systémy Linux. Testování dokazuje úspěšnost blokování L7-filtrem a IPP2P filtrem.

  18. On the mod $p^7$ determination of ${2p-1\\choose p-1}$

    Mestrovic, Romeo

    2011-01-01

    In this paper we prove that for any prime $p\\ge 11$ holds $$ {2p-1\\choose p-1}\\equiv 1 -2p \\sum_{k=1}^{p-1}\\frac{1}{k} +4p^2\\sum_{1\\le i2p-1\\choose p-1} \\equiv 1 \\,\\,(\\bmod\\,\\,p^3)$ for all primes $p\\ge 5$. Our proof is elementary and it does not use a standard technique involving the classic formula for the power sums in terms of the Bernoulli numbers. Notice that the above congruence reduced modulo $p^6$, $p^5$ and $p^4$ yields related congruences obtained by R. Tauraso, J. Zhao and J.W.L. Glaisher, respectively.

  19. Supporting K nearest neighbors query on high-dimensional data in P2P systems

    Mei LI; Wang-Chien LEE; Anand SIVASUBRAMANIAM; Jizhong ZHAO

    2008-01-01

    Peer-to-peer systems have been widely used for sharing and exchanging data and resources among numerous computer nodes.Various data objects identifiable with high dimensional feature vectors,such as text,images,genome sequences,are starting to leverage P2P technology.Most of the existing works have been focusing on queries on data objects with one or few attributes and thus are not applicable on high dimensional data objects.In this study,we investigate K nearest neighbors query (KNN)on high dimensional data objects in P2P systems.Efficient query algorithm and solutions that address various technical challenges raised by high dimensionality,such as search space resolution and incremental search space refinement,are proposed.An extensive simulation using both synthetic and real data sets demonstrates that our proposal efficiently supports KNN query on high dimensional data in P2P systems.

  20. Investigation of the neon 2p collisional excitation transfer processes via CW laser collisionally induced fluorescence

    We present a method for determining the 2p (in Paschen notation) collisional excitation transfer coefficients in noble gases using continuous-wave laser collisionally induced fluorescence (CW LCIF, i.e. fluorescence from an upper level which is not that of the laser transition). The technique requires isolation of the specific 2p coupling process under examination, whereby that process provides an important and quantifiable contribution to the LCIF. This is achieved by selecting appropriate laser excitation and LCIF transitions. For a neon discharge operating at pressures ranging from 1.5 to 8.0 Torr and currents from 1 to 10 mA, 2p coupling is by ground-state atom collisions and the largest coupling exists between adjacent states. We show that in certain cases excitation transfer plays an important role in the excited-state kinetics. (author)

  1. On the Design and Implementation of Structured P2P VPNs

    Wolinsky, David Isaac; Lee, Kyungyong; Liu, Yonggang; Xu, Jiangyan; Boykin, P Oscar; Figueiredo, Renato

    2010-01-01

    Centralized Virtual Private Networks (VPNs) when used in distributed systems have performance constraints as all traffic must traverse through a central server. In recent years, there has been a paradigm shift towards the use of P2P in VPNs to alleviate pressure placed upon the central server by allowing participants to communicate directly with each other, relegating the server to handling session management and supporting NAT traversal using relays when necessary. Another, less common, approach uses unstructured P2P systems to remove all centralization from the VPN. These approaches currently lack the depth in security options provided by other VPN solutions, and their scalability constraints have not been well studied. In this paper, we propose and implement a novel VPN architecture, which uses a structured P2P system for peer discovery, session management, NAT traversal, and autonomic relay selection and a central server as a partially-automated public key infrastructure (PKI) via a user-friendly web inte...

  2. Public Key Cryptosystem Approach for P2P Botnet Detection and Prevention

    Anas Aliyu Usman

    2015-04-01

    Full Text Available Distributed (P2P botnets have as of late been received by botmasters for their versatility against take-down endeavors. Other than being harder to bring down, p2p botnets tend to be stealthier in the way they perform vindictive exercises, making current discovery approaches ineffectual. In this paper, we simulate our proposal by detecting a gray hole attack in an Ad Hoc network using NS2.The detected malicious node is listed in a black hole list and notices all other nodes in the network to stop communicating with them. Our botnet location framework has been equipped for identifying stealthy P2P botnets (Gray Hole nodes and can reduce packet loss caused by malicious nodes and have a better packet delivery ratio (PDR within less period of time.

  3. Analysis of the (p,2p) reaction in an asymmetric energy-sharing mode

    A half distorted-wave formalism, applicable specifically to the anlaysis of the (p,2p) reaction in an asymmetric energy-sharing mode, is developed. The formalism explicitly includes t-matrix operators of central and tensor forms, and the expansion of the technique to include an intermediate giant resonance excitation mechanism is discussed. Application is made to analyses of the 12C(p,2p) reaction in both symmetric and asymmetric energy-sharing geometries and, when semi-phenomenological effective interaction forms of the type in current use in the analysis of (p,p') data are used, it is shown that the spectroscopic information extracted from the analysis of the asymmetric mode (p,2p) data is in good agreement with the predictions of Op shell model calculations

  4. Magnetic and transport properties of a strongly anisotropic ferromagnet, UCu2P2

    We report here the results of the magnetisation and electrical resistivity measurements on UCu2P2 single crystals. This phosphide, crystallizing in the hexagonal structure of CaAl2Si2 type, appears to be a strongly anisotropic ferromagnet with evidence of a significant domain effect at low temperatures. Its Curie temperature is as high as 216 K which is the record for any known ferromagnetic uranium compounds. The anisotropy field is of the order of magnitude of 106Oe. The electrical resistivity results of UCu2P2 undoubtedly point to the semimetallic character of this compound. The character of magnetism in UCu2P2 as well as the origin of its very high Tc are discussed. We present also the magnetic ordering analysis based on the molecular-field approximation. As a result, we found four different magnetic structures which can occur for compounds with the CaAl2Si2-type crystal structure. (author)

  5. YEAST PRION PROTEIN Ure2p – A USEFUL MODEL FOR HUMAN PRION DISEASES.

    Tatina T. Todorova

    2015-03-01

    Full Text Available Mammalian transmissible spongiform encephalopathies are uncommon and irreversible diseases caused by prions. Prions lack nucleic acid and can self-propagate by converting normal cell protein to isomeric prion form. In the pathogenesis of these diseases a long variable incubation period occurs, followed by progressive appearance of severe clinical symptoms and death. A major knowledge in the field of prions comes from studies on a functionally unrelated protein of yeast Saccharomyces cerevisiae – [URE3], which in normal state (Ure2p possesses a variety of regulatory and enzymatic functions. Ure2p is a cytoplasmic homodimeric protein with structural homology to glutathione S-transferases and crucial role in nitrogen metabolism, oxidant protection and heavy metal resistance in yeast. In this work, we discuss the role of Ure2p to provide valuable information about protein infectivity, prion structure and functions.

  6. Improved Optimal Searching Techniques in Distributed P2P networks using Guided Protocol Approach

    S.Bhaskaran

    2009-12-01

    Full Text Available peer-to-peer (P2P networks establish looselycoupled application-level overlays on top of the Internetto facilitate efficient sharing of resources. They canbe roughly classified as either structured or unstructurednetworks. Without stringent constraints over the networktopology, unstructured P2P networks can be constructedvery efficiently and are therefore considered suitable tothe Internet environment. However, the random searchstrategies adopted by these networks usually performpoorly with a large network Size. In this paper, we seekto enhance the search performance in unstructured P2Pnetworks through exploiting users’ commoninterest patterns captured within a probability-theoreticframework based on DHT . A search protocol and arouting table updating protocol are further proposed inorder to expedite the search process through selforganizing the P2P network into a small world.

  7. An Adaptive P2P Topology Evolvement Model Based on Interest Similarity

    Li Yang

    2010-11-01

    Full Text Available To improve the resource location efficiency and guarantee resource download quality of nodes inP2P systems, we propose a node Interest bias based P2P Interest domain partition mechanism, givethe concept of Interest similarity as well as its computation method, and then present an adaptive P2Ptopology evolvement model ISPT based on interest similarity ISPT. In ISPT, by computing interestsimilarity of each other, nodes with similar interest bias and service trust value are connected asneighbors. Since nodes that have similar interest are more likely to share resources, ISPT improvesnode resource query response efficiency, and provides an incentive mechanism to encourage nodeoffer more contribution so as to get better service. Simulation results show that ISPT improves theefficiency and security of P2P topology effectively.

  8. A Group-oriented Access Control Scheme for P2P Networks

    Wang Xiaoming

    2011-02-01

    Full Text Available A group-oriented access control scheme is proposed for P2P (peer to peer networks. In the proposed scheme, authentication control, admission control and revocation control are used in order to provide security services for P2P networks. Moreover, the proposed scheme can simply and efficient establish share key between two members without interactions, therefore it can perform secure communications with them. The analysis of security and performance shows that the proposed scheme not only can realize authentication and secure communication, but also can easily and efficiently add new group members and revoke malicious group members. Therefore, it is more efficient, and more practical protocol for P2P networks.

  9. Cycles of small codimension on a simple 2p- or 4p-dimensional Abelian variety

    Tankeev, Sergei G [Vladimir State University (Russian Federation)

    1999-12-31

    Let J be a simple 2p- or 4p-dimensional Abelian variety over the field of complex numbers, where p{ne}5 is a prime number. Assume that one of the following conditions holds: 1) Cent End{sup 0}(J) is a totally real field of degree 1, 2 or 4 over Q; 2) J is a simple 2p-dimensional Abelian variety of CM-type (K,{phi}) such that K/Q is a normal extension; 3) J is a simple 2p-dimensional Abelian variety such that End{sup 0}(J) is an imaginary quadratic extension of Q. Then for every positive integer r

  10. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.

    Tambe, Mahesh; Pruikkonen, Sofia; Mäki-Jouppila, Jenni; Chen, Ping; Elgaaen, Bente Vilming; Straume, Anne Hege; Huhtinen, Kaisa; Cárpen, Olli; Lønning, Per Eystein; Davidson, Ben; Hautaniemi, Sampsa; Kallio, Marko J

    2016-03-15

    The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs. We demonstrate miR-493-3p to be a novel negative regulator of mitotic arrest deficient-2 (MAD2), an essential component of the spindle assembly checkpoint that monitors the fidelity of chromosome segregation. The microRNA targets the 3' UTR of Mad2 mRNA thereby preventing translation of the Mad2 protein. In cancer cells, overexpression of miR-493-3p induced a premature mitotic exit that led to increased frequency of aneuploidy and cellular senescence in the progeny cells. Importantly, excess of the miR-493-3p conferred resistance of cancer cells to microtubule drugs. In human neoplasms, miR-493-3p and Mad2 expression alterations correlated with advanced ovarian cancer forms and high miR-493-3p levels were associated with reduced survival of ovarian and breast cancer patients with aggressive tumors, especially in the paclitaxel therapy arm. Our results suggest that intratumoral profiling of miR-493-3p and Mad2 levels can have diagnostic value in predicting the efficacy of taxane chemotherapy. PMID:26943585

  11. Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.

    Kershaw, Christopher J; Costello, Joseph L; Talavera, David; Rowe, William; Castelli, Lydia M; Sims, Paul F G; Grant, Christopher M; Ashe, Mark P; Hubbard, Simon J; Pavitt, Graham D

    2015-01-01

    The PUF family of RNA-binding proteins regulate gene expression post-transcriptionally. Saccharomyces cerevisiae Puf3p is characterised as binding nuclear-encoded mRNAs specifying mitochondrial proteins. Extensive studies of its regulation of COX17 demonstrate its role in mRNA decay. Using integrated genome-wide approaches we define an expanded set of Puf3p target mRNAs and quantitatively assessed the global impact of loss of PUF3 on gene expression using mRNA and polysome profiling and quantitative proteomics. In agreement with prior studies, our sequencing of affinity-purified Puf3-TAP associated mRNAs (RIP-seq) identified mRNAs encoding mitochondrially-targeted proteins. Additionally, we also found 720 new mRNA targets that predominantly encode proteins that enter the nucleus. Comparing transcript levels in wild-type and puf3∆ cells revealed that only a small fraction of mRNA levels alter, suggesting Puf3p determines mRNA stability for only a limited subset of its target mRNAs. Finally, proteomic and translatomic studies suggest that loss of Puf3p has widespread, but modest, impact on mRNA translation. Taken together our integrated multi-omics data point to multiple classes of Puf3p targets, which display coherent post-transcriptional regulatory properties and suggest Puf3p plays a broad, but nuanced, role in the fine-tuning of gene expression. PMID:26493364

  12. 基于 P2P 网络的 Bitcoin 虚拟货币分析%Bitcoin Virtual Currency Analysis Based on P2P

    石苗; 李宥谋

    2015-01-01

    Bitcoin 是一种基于 P2P 网络的匿名数字货币,论文从网络虚拟货币的发展现状出发,从技术层面详细分析Bitcoin 形成相关技术原理及其交易过程和验证机制,肯定了其历史性和革命性。同时分析 Bitcoin 存在的各方面问题,探究其在网络虚拟货币统一方面的重要借鉴意义。%Bitcoin is an anonymous digital cash based on P2P network .In this paper ,starting from the development present situation of the network virtual currency ,detailed analysis formation related technical principles and transaction process and the authentication mechanism from the technical level of Bitcoin ,affirmed its historical and revolutionary .At the same time ,aspects of problems of Bitcoin are analyzed ,its importance in the network virtual currency unification is explored .

  13. Excitation of the (2p2)1D and (2s2p)1P autoionizing states of helium by 200 eV electron impact

    We report full second Born calculations with inclusion of post-collision interactions for excitation of the (2p2)1D and (2s2p)1P autoionizing states of helium by 200 eV electron impact. The calculations are compared to (e, 2e) measurements of McDonald and Crowe (McDonald D G and Crowe A 1993 J. Phys. B: At. Mol. Opt. Phys. 26 2887-97) and Lower and Weigold (Lower J and Weigold E 1990 J. Phys. B: At. Mol. Opt. Phys. 23 2819-45). It is shown that post-collision interactions or Coulomb interactions in the final state between the scattered particle, the ejected electron and the recoil ion have a strong influence on both the direct ionization and resonance profiles around the binary lobe. The second-order terms in the amplitude of double electron excitation also play an observable role under these kinematic conditions. Reasonable agreement is found between the full-scale calculations and the experimental data. (author). Letter-to-the-editor

  14. Bitcoin Virtual Currency Analysis Based on P2P%基于 P2P 网络的 Bitcoin 虚拟货币分析

    石苗; 李宥谋

    2015-01-01

    Bitcoin is an anonymous digital cash based on P2P network .In this paper ,starting from the development present situation of the network virtual currency ,detailed analysis formation related technical principles and transaction process and the authentication mechanism from the technical level of Bitcoin ,affirmed its historical and revolutionary .At the same time ,aspects of problems of Bitcoin are analyzed ,its importance in the network virtual currency unification is explored .%Bitcoin 是一种基于 P2P 网络的匿名数字货币,论文从网络虚拟货币的发展现状出发,从技术层面详细分析Bitcoin 形成相关技术原理及其交易过程和验证机制,肯定了其历史性和革命性。同时分析 Bitcoin 存在的各方面问题,探究其在网络虚拟货币统一方面的重要借鉴意义。

  15. Complexes of (EtO){sub 2}P(O)CH{sub 2}P(O)(OEt){sub 2} with lanthanide nitrates

    Lees, A.M.J.; Platt, A.W.G. [Staffordshire Univ., School of Sciences, College Road, Stoke-on-Trent (United Kingdom); Kresinski, A. [Kingston Univ., School of Chemical and Pharmaceutical Sciences (United Kingdom)

    2004-12-01

    The preparation of complexes of (EtO){sub 2}P(O)CH{sub 2}P(O)(OEt){sub 2} = L, with lanthanide nitrates is described. Stable complexes with composition LnL{sub 2}(NO{sub 3}){sub 3} can be isolated for Ln = La-Eu and fully characterised. For LnGd-Lu solid compounds could not be isolated. Conductivity and {sup 31}P NMR spectroscopy indicate structural changes in solution between the lighter and heavier lanthanides and, whilst electro-spray mass spectrometry confirms a dramatic difference in behaviour with complexes of the heavier lanthanides readily decomposing via loss of EtNO{sub 3}, other experiments show that this does not occur under the conditions of complex formation. The single crystal X-ray structures for Ln = La and Sm show the nitrates and OEt groups to be in close proximity. The changes in spectroscopic properties correlate well with the difficulties in isolating the complexes of heavier metals, and are possibly due to the formation of dimeric complexes rather than loss of ethyl nitrate. (authors)

  16. A Participation-Based Trust Model for Mobile P2P Networks

    Kai Liu

    2014-07-01

    Full Text Available Mobile peer-to-peer (P2P networks have become increasingly popular, but the attacks and selfness of peers make it vulnerable. In this paper, a trust model based on participation is proposed for mobile P2P networks (called ParticipationTrust. It could deal with the egoistic and malicious behaviors. And the level of peer’s participation could be calculated through the transaction participation and recommendation participation. A set of experiments show that the model is rational and effective

  17. Cluster based hierarchical resource searching model in P2P network

    Yang Ruijuan; Liu Jian; Tian Jingwen

    2007-01-01

    For the problem of large network load generated by the Gnutella resource-searching model in Peer to Peer (P2P) network, a improved model to decrease the network expense is proposed, which establishes a duster in P2P network,auto-organizes logical layers, and applies a hybrid mechanism of directional searching and flooding. The performance analysis and simulation results show that the proposed hierarchical searching model has availably reduced the generated message load and that its searching-response time performance is as fairly good as that of the Gnutella model.

  18. A Measurement Study of the Structured Overlay Network in P2P File-Sharing Systems

    Xiaoming Li; Yafei Dai; Mo Zhou

    2007-01-01

    The architecture of P2P file-sharing applications has been developing to meet the needs of large scale demands. The structured overlay network, also known as DHT, has been used in these applications to improve the scalability, and robustness of the system, and to make it free from single-point failure. We believe that the measurement study of the overlay network used in the real file-sharing P2P systems can provide guidance for the designing of such systems, and improve the performance of th...

  19. A Survey and Synthesis of User Behavior Measurements in P2P Streaming Systems

    Ullah, Ihsan; Doyen, Guillaume; Bonnet, Grégory; Gaïti, Dominique

    2012-01-01

    International audience In terms of scalability, cost and ease of deployment, the Peer-to-Peer (P2P) approach has emerged as a promising solution for video streaming applications. Its architecture enables end-hosts, called peers, to relay the video stream to each ot her. P2P systems are in fact networks of users who control peers. Thus, user behavior is crucial to the performance of these systems because it directly impacts the streaming flow. To understand user behavior, several measuremen...

  20. Enabling Co-located Learning over Mobile Ad Hoc P2P with LightPeers

    Christensen, Bent Guldbjerg; Kristensen, Mads Darø; Hansen, Frank Allan;

    2008-01-01

    This paper presents LightPeers – a new mobile P2P framework specifically tailored for use in a nomadic learning environment. A set of key requirements for the framework is identified based on nomadic learning, and these requirements are used as outset for designing and implementing the architecture...... and protocols. The main contributions of the LightPeers framework are: a mobile P2P framework including a specialized robust messaging protocol resilient to changes in the network topology, an developers API, and a suite of LightPeers applications supporting nomadic learning prototyping key features...

  1. Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe

    She, Meipei; Decker, Carolyn J.; Chen, Nan; Tumati, Suneeta; Parker, Roy; Song, Haiwei

    2005-01-01

    Decapping is a key step in both general and nonsense-mediated 5′ → ′ mRNA-decay pathways. Removal of the cap structure is catalyzed by the Dcp1–Dcp2 complex. The crystal structure of a C-terminally truncated Schizosaccharomyces pombe Dcp2p reveals two distinct domains: an all-helical N-terminal domain and a C-terminal domain that is a classic Nudix fold. The C-terminal domain of both Saccharomyces cerevisiae and S. pombe Dcp2p proteins is sufficient for decapping activity, although the N-term...

  2. P2P Web Search: Make It Light, Make It Fly (Demo)

    Bender, Matthias; Crecelius, Tom; Michel, Sebastian; Parreira, Josiane Xavier

    2007-01-01

    We propose a live demonstration of MinervaLight, a {P2P} Web search engine. MinervaLight combines the (previously separate) focused crawler {BINGO!} (to harvest Web data), the local search engine Top{X}, and our {P2P} Web search system {MINERVA} under one common user interface. The crawler unattendedly downloads and indexesWeb data, where the scope of the focused crawl can be tailored to the thematic interest profile of the user. The result of this process is a local s...

  3. Amplification at λ ∼ 2.8 A on Xe(L),(2s-bar2p-bar) double-vacancy states produced by 248 nm excitation of Xe clusters in plasma channels

    Xe(L),(2s-bar2p-bar) double-vacancy states undergo strong amplification in relativistic self-trapped plasma channels on 3d → 2p transitions in the λ = 2.78-2.81 A region. The 2P3/2 → 2S1/2 component at λ ≅ 2.786 A exhibits saturated amplification demonstrated by both (1) the observation of spectral hole-burning in the spontaneous emission profile and (2) the correlated enhancement of 3p → 2s cascade transitions (2S1/2 → 2Pj; j = 1/2, 3/2) at λ = 2.558 and λ = 2.600 A. The condition of saturation places a lower limit of ∼1017 W cm-2 on the intensity of the x-ray beam produced by the amplification in the channel. The anomalous strength of the amplification signalled by the saturation mirrors the equivalently anomalous behaviour observed for all 3d → 2p transitions corresponding to 2p-bar) single-vacancy Xeq+ arrays (q = 31, 32, 34, 35, 36) that exhibit gain. The conspicuous absence of amplification involving states with (2p-bar)2 double-vacancy configurations suggests the operation of a selective interaction that enhances the production of 2s-bar2p-bar states. Overall, the generation of double-vacancy states of this genre demonstrates that an excitation rate approaching ∼1 W/atom for ionic species is achievable in self-trapped plasma channels

  4. A Distributed Dynamic Super Peer Selection Method Based on Evolutionary Game for Heterogeneous P2P Streaming Systems

    Jing Chen; Rui-Min Wang; Lei Li; Zhi-Hong Zhang; Xiao-She Dong

    2013-01-01

    Due to high efficiency and good scalability, hierarchical hybrid P2P architecture has drawn more and more attention in P2P streaming research and application fields recently. The problem about super peer selection, which is the key problem in hybrid heterogeneous P2P architecture, is becoming highly challenging because super peers must be selected from a huge and dynamically changing network. A distributed super peer selection (SPS) algorithm for hybrid heterogeneous P2P streaming system base...

  5. Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy.

    Ma, Wei; Ma, Chao-Nan; Zhou, Nan-Nan; Li, Xian-Dong; Zhang, Yi-Jie

    2016-01-01

    MicroRNAs (miRNAs) are believed to be resistant against radiotherapy in certain types of cancers. The aim of our study was to determine the clinical application of miRNAs in non-small cell lung cancer (NSCLC). Sixty NSCLC tissue samples and adjacent histologically normal tissues were obtained for miRNAs microarray analysis and validated by RT-qPCR. Correlation between miRNA expression level and clinicopathological features was evaluated. Our study examined the influence of changed miRNA expression on the damaged DNA and its associated radio sensitivity. Luciferase assay was performed to determine potential effects on the targeted gene. Our study identified fifteen altered miRNAs in which miR-328-3p was down regulated in NSCLC tumour tissue as compared to normal tissues. Down-expression of miR-328-3p was positively associated with an enhanced lymph node metastasis, advanced clinical stage and a shortened survival rate. miR-328-3p expression was decreased in A549 cells compared to other NSCLC cell lines. Up-regulation of miR-328-3p demonstrated a survival inhibition effect in A549 and restored NSCLC cells' sensitivity to radio therapy. An increased miR-328-3p expression promoted irradiation-induced DNA damage in cells. γ-H2AX was identified as the direct target of miR-328-3p. Over-expressed miR-328-3p can improve the radiosensitvity of cells by altering the DNA damage/repair signalling pathways in NSCLC. PMID:27530148

  6. Colloidal CdSe/Cu3P/CdSe nanocrystal heterostructures and their evolution upon thermal annealing.

    De Trizio, Luca; De Donato, Francesco; Casu, Alberto; Genovese, Alessandro; Falqui, Andrea; Povia, Mauro; Manna, Liberato

    2013-05-28

    We report the synthesis of colloidal CdSe/Cu(3)P/CdSe nanocrystal heterostructures grown from hexagonal Cu(3)P platelets as templates. One type of heterostructure was a sort of "coral", formed by vertical pillars of CdSe grown preferentially on both basal facets of a Cu(3)P platelet and at its edges. Another type of heterostructure had a "sandwich" type of architecture, formed by two thick, epitaxial CdSe layers encasing the original Cu(3)P platelet. When the sandwiches were annealed under vacuum up to 450 °C, sublimation of P and Cd species with concomitant interdiffusion of Cu and Se species was observed by in situ HR- and EFTEM analyses. These processes transformed the starting sandwiches into Cu2Se nanoplatelets. Under the same conditions, both the pristine (uncoated) Cu(3)P platelets and a control sample made of isolated CdSe nanocrystals were stable. Therefore, the thermal instability of the sandwiches under vacuum might be explained by the diffusion of Cu species from Cu(3)P cores into CdSe domains, which triggered sublimation of Cd, as well as out-diffusion of P species and their partial sublimation, together with the overall transformation of the sandwiches into Cu(2)Se nanocrystals. A similar fate was followed by the coral-like structures. These CdSe/Cu(3)P/CdSe nanocrystals are therefore an example of a nanostructure that is thermally unstable, despite its separate components showing to be stable under the same conditions. PMID:23557168

  7. Determination of high-energy radiation doses with Agfa-Gevaert Structurix D2p films

    A linear dependence of the optical density of Agfa-Gevaert Structurix D2p films on the dose and energy of radiation obtained in electron linacs in the range between 0,1 and 1 Gy is studied. The accuracy of the photometric method is estimated and the conditions of the photochemical processing are described. 4 figs., 1 tab., 2 refs. (author)

  8. Implementation of P2P Reputation Management Using Distributed Identities and Decentralized Recommendation Chains

    P.Satheesh

    2012-06-01

    Full Text Available In this paper, we investigate Reputation Systems for P2P networks more ambitious approach to protect the P2P network without using any central component, and thereby harnessing the full benefits of the P2P network. The reputations of the peers are used to determine whether a peer is a malicious peer or a good peer. Once detected, the malicious peers are ostracized from the network as the good peers do not perform any transactions with the malicious peers. Expulsion of malicious peers from the network significantly reduces the volume of malicious activities. All peers in the P2P network are identified by identity certificates. The reputation of a given peer is attached to its identity. The identity certificates are generated using self-certification, and all peers maintain their own certificate authority which issues the identity certificates to the peer. Each peer owns the reputation information pertaining to all its past transactions with other peers in the network, and stores it locally. A two-party cryptographic protocol not only protects the reputation information from its owner, but also facilitates secure exchange of reputation information between the two peers participating in a transaction

  9. IPTV-RM: A Resources Monitoring Architecture for P2P IPTV Systems

    Wenxian Wang

    2012-10-01

    Full Text Available Resources monitoring is an important problem of the overall efficient usage and control of P2P IPTV systems. The resources of IPTV can include all distributing servers, programs and peers. Several researches have tried to address this issue, but most of them illuminated P2P traffic characterization, identification and user behavior. The main contributions of this paper are twofold. Firstly, a resources monitoring architecture for P2P IPTV systems, IPTV-RM, was presented based on previous work. The monitoring architecture employs a hierarchical structure and provides systemic monitoring including resources discovery, relative information extraction and analysis, trace and location. It gives a systematic framework for IPTV resources monitoring. Secondly, a distributed program crawling system (DMP-Crawler was first proposed to collect information of programs, and a peer crawling system was put forward to harvest peers of a program. The results show that they are efficient and can be used for resource collection of other P2P system. 

  10. Traceable P2P record exchange: a database-oriented approach

    Fengrong LI; Takuya IIDA; Yoshiharu ISHIKAWA

    2008-01-01

    In recent years,peer-to-peer (P2P) technologies are used for flexible and scalable information exchange in the Internet,but there exist problems to be solved for reliable information exchange.It is important to trace how data circulates between peers and how data modifications are performed during the circulation before reaching the destination for enhancing the reliability of exchanged information.However,such lineage tracing is not easy in current P2P networks,since data replications and modifications are performed independently by autonomous peers--this creates a lack of reliability among the records exchanged.In this paper,we propose a framework for traceable record exchange in a P2P network.By managing historical information in distributed peers,we make the modification and exchange histories of records traceable.One of the features of our work is that the database technologies are utilized for realizing the framework.Histories are maintained in a relational database in each peer,and tracing queries are written in the datalog query language and executed in a P2P network by cooperating peers.This paper describes the concept of the framework and overviews the approach to query processing.

  11. A role for K2P channels in the operation of somatosensory nociceptors

    Leigh Daniel Plant

    2012-03-01

    Full Text Available The ability to sense mechanical, thermal and chemical stimuli is critical to normal physiology and the perception of pain. Contact with noxious stimuli triggers a complex series of events that initiate innate protective mechanisms designed to minimize or avoid injury. Extreme temperatures, mechanical stress and chemical irritants are detected by specific ion channels and receptors clustered on the terminals of nociceptive sensory nerve fibers and transduced into electrical information. Propagation of these signals, from distant sites in the body to the spinal cord and the higher processing centers of the brain, is also orchestrated by distinct groups of ion channels. Since their identification in 1995, evidence has emerged to support roles for K2P channels at each step along this pathway, as receptors for physiological and noxious stimuli, and as determinants of nociceptor excitability and conductivity. In addition, the many subtypes of K2P channels expressed in somatosensory neurons are also implicated in mediating the effects of volatile, general anesthetics on the central and peripheral nervous systems. Here, I offer a critical review of the existing data supporting these attributes of K2P channel function and discuss how diverse regulatory mechanisms that control the activity of K2P channels act to govern the operation of nociceptors.

  12. Recent Replica Placement Algorithms in P2P Networks – A Review

    Kala Karun. A

    2013-04-01

    Full Text Available Peer-to-Peer (P2P systems provide a platform for large internet scale distributed applications with no dedicated infrastructure. In P2P systems, applications are developed by dividing them across individual systems termed peers which take the role of both client as well as server. Popularity of objects in such a system can change rapidly, which demands the need for a rapid and light weight content replication strategy which considers this dynamic popularity changes. While considering P2P in distributed file sharing applications, data availability has significant impact on the system's performance. In addition to optimized availability, the replica placement should guarantee reduced search and data access latency. It should be dynamically adaptable to instantaneous query arrival rate as well as dynamic membership of individual peers. Also, it should provide good performance with reduced number of control messages. Thus an intelligent placement of replicas considering various factors of the system always outperforms a random placement of replicas on random peers. This paper reviews and compares various recent replica placement algorithms for structured as well as unstructured P2P networks.

  13. NEUT development for T2K and relevance of updated 2p2h models

    Wilkinson, Callum

    2015-01-01

    The MiniBooNE large axial-mass anomaly has motivated the development of new theoretical Charged Current Quasi-Elastic (CCQE) cross-section models in recent years. These proceedings review the development of the neutrino simulation generator NEUT to incorporate these more sophisticated CCQE models, including multi-nucleon interaction (2p2h) effects. The fit results on the MINER$\

  14. Identifying file-sharing P2P traffic based on traffic characteristics

    2008-01-01

    This article focuses on identifying file-sharing peer-to-peer (P2P) (such as BitTorrent (BT)) traffic at the borders of a stub network. By analyzing protocols and traffic of applications, it is found that file-sharing P2P traffic of a single user differs greatly from traditional and other P2P (such as QQ) applications' traffic in the distribution of involved remote hosts and remote ports. Therefore, a method based on discreteness of remote hosts (RHD) and discreteness of remote ports (RPD) is proposed to identify BT-like traffic. This method only relies on flow information of each user host in a stub network, and no packet payload needs to be monitored. At intervals, instant RHD for concurrent transmission control protocol and user datagram protocol flows for each host are calculated respectively through grouping flows by the stub network that the remote host of each flow belongs to. On given conditions, instant RPD are calculated through grouping flows by the remote port to amend instant RHD. Whether a host has been using a BT-like application or not can be deduced from instant RHD or average RHD for a period of time. The proposed method based on traffic characteristics is more suitable for identifying protean file-sharing P2P traffic than content-based methods. Experimental results show that this method is effective with high accuracy.

  15. Electrical properties of the anisotropic n-ТiО2/P-CdTe heterojunctions

    Брус, Віктор Васильович; Ілащук, Марія Іванівна; Ковалюк, Захар Дмитрович; Мар’янчук, Павло Дмитрович; Ульяницький, Костянтин Сергійович; Кафанов, Анатолій Михайлович

    2012-01-01

    The electrical properties of the n-ТіО2/p-CdTe, prepared by deposition of TiO2 film onto freshly cleaved CdTe single crystal substrates were investigated. The electric current in the heterojunctions is induced by generation-recombination processes within the depletion region and tunneling of carriers

  16. Database selection and result merging in P2P web search

    Chernov, S.; Serdyukov, P.; Bender, M.; Michel, S.; Weikum, G.; Zimmer, C.

    2005-01-01

    Intelligent Web search engines are extremely popular now. Currently, only the commercial centralized search engines like Google can process terabytes of Web data. Alternative search engines fulfilling collaborative Web search on a voluntary basis are usually based on a blooming Peer-to-Peer (P2P) te

  17. Photoionization of atomic scandium in the region of the 2p resonances

    The 2p resonances of atomic scandium at 391-410 eV were studied by photoion spectroscopy using monochromatized synchrotron radiation and the atomic beam technique. The partial ion yield spectra for singly to quadruple charged photoions were observed. The comparison of the total ion yield spectrum with the calculated absorption spectrum shows surprisingly good results. (author). Letter-to-the-editor

  18. Scaling laws for file dissemination in P2P networks with random contacts

    Nunez-Queija, R.; Prabhu, B.

    2008-01-01

    In this paper we obtain the scaling law for the mean broadcast time of a file in a P2P network with an initial population of N nodes. In the model, at Poisson rate λ a node initiates a contact with another node chosen uniformly at random. This contact is said to be successful if the contacted node p

  19. Scaling laws for file dissemination in P2P networks with random contacts

    R. Núñez-Queija; B. Prabhu

    2008-01-01

    In this paper we obtain the scaling law for the mean broadcast time of a file in a P2P network with an initial population of N nodes. In the model, at Poisson rate lambda a node initiates a contact with another node chosen uniformly at random. This contact is said to be successful if the contacted n

  20. Electronic Structure and Optical Properties Of EuIn2P2

    Singh, Nirpendra

    2011-10-25

    The electronic structures and, optical and magneto‐optical properties of a newly found Zintl compound EuIn2P2 have been investigated within the density‐functional theory using the highly precise full‐potential linear‐augmented‐plane‐wave method. Results of detailed investigation of the electronic structure and related properties are reported.

  1. SemTrust: A Semantic Reputation System in P2P-Based Semantic Web

    WANG Wei; ZENG Guosun; YUAN Lulai

    2006-01-01

    A reputation mechanism is introduced in P2P-based Semantic Web to solve the problem of lacking trust. It enables Semantic Web to utilize reputation information based on semantic similarity of peers in the network. This approach is evaluated in a simulation of a content sharing system and the experiments show that the system with reputation mechanism outperforms the system without it.

  2. A Novel Syndrome Affecting Multiple Mitochondrial Functions, Located by Microcell-Mediated Transfer to Chromosome 2p14-2p13

    Seyda, Agnieszka; Newbold, Robert F.; Hudson, Thomas J.; Verner, Andrei; MacKay, Neviana; Winter, Susan; Feigenbaum, Annette; Malaney, Suzann; Gonzalez-Halphen, Diego; Cuthbert, Andrew P.; Robinson, Brian H.

    2001-01-01

    We have studied cultured skin fibroblasts from three siblings and one unrelated individual, all of whom had fatal mitochondrial disease manifesting soon after birth. After incubation with 1 mM glucose, these four cell strains exhibited lactate/pyruvate ratios that were six times greater than those of controls. On further analysis, enzymatic activities of the pyruvate dehydrogenase complex, the 2-oxoglutarate dehydrogenase complex, NADH cytochrome c reductase, succinate dehydrogenase, and succinate cytochrome c reductase were severely deficient. In two of the siblings the enzymatic activity of cytochrome oxidase was mildly decreased (by ∼50%). Metabolite analysis performed on urine samples taken from these patients revealed high levels of glycine, leucine, valine, and isoleucine, indicating abnormalities of both the glycine-cleavage system and branched-chain α-ketoacid dehydrogenase. In contrast, the activities of fibroblast pyruvate carboxylase, mitochondrial aconitase, and citrate synthase were normal. Immunoblot analysis of selected complex III subunits (core 1, cyt c1, and iron-sulfur protein) and of the pyruvate dehydrogenase complex subunits revealed no visible changes in the levels of all examined proteins, decreasing the possibility that an import and/or assembly factor is involved. To elucidate the underlying molecular defect, analysis of microcell-mediated chromosome-fusion was performed between the present study's fibroblasts (recipients) and a panel of A9 mouse:human hybrids (donors) developed by Cuthbert et al. (1995). Complementation was observed between the recipient cells from both families and the mouse:human hybrid clone carrying human chromosome 2. These results indicate that the underlying defect in our patients is under the control of a nuclear gene, the locus of which is on chromosome 2. A 5-cM interval has been identified as potentially containing the critical region for the unknown gene. This interval maps to region 2p14-2p13. PMID

  3. The 2P1/2 → 2P3/2 laser transition in atomic iodine and the problem of search for signals from extraterrestrial intelligence

    It is proposed to search for signals from extraterrestrial intelligence (ETI) at a wavelength of 1.315 μm of the laser 2P1/2 → 2P3/2 transition in the atomic iodine, which can be used for this purpose as the natural frequency reference. The search at this wavelength is promising because active quantum filters (AQFs) with the quantum sensitivity limit have been developed for this wavelength, which are capable of receiving laser signals, consisting of only a few photons, against the background of emission from a star under study. In addition, high-power iodine lasers emitting diffraction-limited radiation at 1.315 μm have been created, which highly developed ETI also can have. If a ETI sends in our direction a diffraction-limited 10-ns, 1-kJ laser pulse with the beam diameter of 10 m, a receiver with an AQF mounted on a ten-meter extra-atmospheric optical telescope can detect this signal at a distance of up to 300 light years, irrespective of the ETI position on the celestial sphere. The realisation of the projects for manufacturing optical telescopes of diameter 30 m will increase the research range up to 2700 light years. A weak absorption of the 1.315-μm radiation in the Earth atmosphere (the signal is attenuated by less than 20%) allows the search for ETI signals by using ground telescopes equipped with adaptive optical systems. (laser applications and other topics in quantum electronics)

  4. Formulation development and evaluation of innovative two-polymer (SR-2P) bioadhesive vaginal gel.

    Podaralla, Satheesh; Alt, Carsten; Shankar, Gita N

    2014-08-01

    The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI's proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal semen dilutions, and bioadhesivity using ex vivo mini pig vaginal tissues and texture analyzer. The pH of the polymeric gel formulations ranged from 5.1 to 6.4; the osmolality varied from 13 to 173 mOsm. Absolute viscosity ranged from 513 to 3,780 cPs, and was significantly reduced (1.5- to 3-fold) upon incubation with simulated vaginal and semen fluid mixture. Among the tested gels (indicated in the middle row as a molar ratio of a mixture of Noveon vs. Pluronic), only SR-2P retained gel structure upon dilution with simulated fluids and mild simulated coital stress. The pH of the SR-2P gel was maintained at about 4.6 in simulated vaginal fluid and also showed high peak force of adhesion in mini pig vaginal tissue. Furthermore, SR-2P gel caused no or only minimal irritation in a mouse vaginal irritation model. The results of this preliminary study demonstrated the potential application of SR-2P gel as a vaginal microbicide vehicle for delivery of anti-HIV agents. PMID:24781671

  5. O2, pH, and redox potential microprofiles around Potamogeton malaianus measured using microsensors.

    Bin Dong

    Full Text Available This study aimed to elucidate the effects of periphyton on the microprofiles of oxygen (O2, pH, and oxidation-reduction potential around the stems and leaves of a submerged macrophyte Potamogeton malaianus and on the plant growth in the eutrophic shallow Taihu Lake, China. The microprofiles were measured using a motorized microprofiling system equipped with microsensors. The leaf age of the macrophyte and periphyton exerted significant effects on the microprofiles of O2, pH, and oxidation-reduction potential. O2 concentration and pH increased whereas the oxidation-reduction potential decreased with decreasing distance to the stem/leaf surface. The fluctuation amplitudes of O2, pH, and oxidation-reduction potential were the largest in the microprofiles of mature leaves and the lowest in senescent leaves. The periphyton increased the thickness of the broad diffusive boundary layer and fluctuation amplitudes of O2, pH, and oxidation-reduction potential. When the periphyton was removed, the thickness of the broad diffusive boundary layer in the microprofiles of stems, senescent leaves, and mature leaves reduced by 29.0%, 49.72%, and 70.34%, and the O2, pH, and oxidation-reduction potential fluctuation amplitudes also declined accordingly. Our results suggest that a thick periphyton exerted negative effects on the growth of macrophytes by providing extensive shading and creating a barrier that hindered the transport of dissolved substances such as O2, and led to premature decline in macrophytes in the eutrophic Taihu Lake. The consequent implications can help to elucidate the control mechanism of the broad diffusive boundary layer around macrophytes on nutrient cycling in eutrophic waters and to better understand the role of this layer in the Taihu Lake and other similar eutrophic waters.

  6. The state dependence of the interaction of metastable rare gas atoms Rg sup * (ms sup 3 P sub 2 , sup 3 P sub 0 ) (Rg=Ne, Ar, Kr, Xe) with ground state sodium atoms

    Schohl, S.; Mueller, M.W.; Meijer, H.A.J.; Ruf, M.W.; Hotop, H. (Kaiserslautern Univ. (Germany, F.R.). Fachbereich Physik); Morgner, H. (Witten-Herdecke Univ., Witten (Germany, F.R.). Inst. fuer Experimentalphysik)

    1990-08-01

    Using crossed beams of metastable rare gas atoms Rg{sup *}(ms {sup 3}P{sub 2}, {sup 3}P{sub 0}) (Rg=Ne, Ar, Kr, Xe) and ground state sodium atoms Na(3s {sup 2}S{sub 1/2}), we have measured the energy spectra of electrons released in the respective Penning ionization processes at thermal collision energies. For Rg{sup *}({sup 3}P{sub 2})+Na(3s), the spectra are quite similar for the different rare gases, both in width and shape; they reflect attractive interactions in the entrance channel with well depths D{sub e}{sup *} (meV) decreasing slowly from Rg=Ne to Xe as follows: 676(18); 602(23); 565(26); 555(30). For Rg{sup *}({sup 3}P{sub 0})+Na(3 s), the spectra vary strongly with the rare gas, indicating a change in the character of the interaction from van der Waals type attraction (Ne) to chemical binding for Kr and Xe with well depths D{sub e}{sup *} (meV) of: 51(19); 107(25); 432(30); 530(50). These findings are explained through model calculations of the respective potential curves, in which the exchange and the spin orbit interaction in the excited rare gas and the molecular interaction between the two valence s-electrons in terms of suitably chosen singlet and triplet potentials are taken into account. These calculations also explain qualitatively the experimental finding that the ratios q{sub 2}/q{sub 0} of the ionization cross sections for Rg{sup *}({sup 3}P{sub 2})+Na and Rg{sup *}({sup 3}P{sub 0})+Na vary strongly with the rare gas from Ne to Xe as follows: 15.8(3.2); 2.6(4); 1.4(2); 1.6(4). (orig.).

  7. Physico-chemical studies of MgNa3P3O10·12H2O

    Fahim I.

    2013-09-01

    Full Text Available A magnesium-sodium triphosphate MgNa3P3O10·12H2O already known has been prepared by the method of ion exchange resin of aqueous chemistry and studied by X-Ray diffraction, thermal analyses (TGA-DTA, differential scanning calorimetry (DSC and infrared spectrometry which show the characteristic bands of a triphosphate P3O. The results of differential thermal analysis, X-Ray powder diffraction and IR spectra of the compound heated at different temperatures showed that, after dehydration, MgNa3P3O10·12H2O decomposes into an amorphous compound, then it crystallizes at 600 ° C in order to give the anhydrous triphosphate MgNa3P3O10. MgNa3P3O10 is stable until its melting point at 612 ° C. Two different methods Ozawa and KAS have been selected in studying the kinetics of thermal behavior of the triphosphate P3O10 for the first time. The kinetic and thermodynamic characteristics of the dehydration of MgNa3P3O10·12H2O and the thermal phenomena accompanying this dehydration were determinated and discussed on the basis of the proposed crystalline structure.

  8. MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes.

    Li, Man; Wang, Nan; Zhang, Jian; He, Hong-Peng; Gong, Hui-Qin; Zhang, Rui; Song, Tie-Feng; Zhang, Li-Nan; Guo, Zhi-Xia; Cao, Dong-Sun; Zhang, Tong-Cun

    2016-07-01

    Transcription factor nuclear factor of activated T cells c4 (NFATc4) is the best-characterized target for the development of cardiac hypertrophy. Aberrant microRNA-29 (miR-29) expression is involved in the development of cardiac fibrosis and congestive heart failure. However, whether miR-29 regulates hypertrophic processes is still not clear. In this study, we investigated the potential functions of miR-29a-3p in endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy. We showed that miR-29a-3p was down-regulated in ET-1-treated H9c2 cardiomyocytes. Overexpression of miR-29a-3p significantly reduced ET-1-induced hypertrophic responses in H9c2 cardiomyocytes, which was accompanied by a decrease in NFATc4 expression. miR-29a-3p targeted directly to the 3'-UTR of NFATc4 mRNA and silenced NFATc4 expression. Our results indicate that miR-29a-3p inhibits ET-1-induced cardiomyocyte hypertrophy via inhibiting NFATc4 expression. PMID:26992639

  9. Soft-mode enhanced superconductivity in the antiperovskite APt{sub 3}P, A=Sr, Ca, La

    Heid, Rolf; Bohnen, Klaus-Peter [Institut fuer Festkoerperphysik, Karlsruher Institut fuer Technologie (Germany)

    2013-07-01

    The surprising discovery of superconductivity in iron pnictides initiated an increased search for superconductivity in other unconventional compounds. Recently, a new class of P-based antiperovskites was synthesized, and superconductivity with a T{sub c} of 8.4 K was observed for SrPt{sub 3}P. Specific heat measurements indicated a strong-coupling scenario and the presence of low-energy phonon modes. Replacing Sr by Ca or La resulted in lower T{sub c}'s and a progressive loss of strong-coupling signatures. Here we present results of a first principles study of lattice dynamics and electron-phonon coupling properties of APt{sub 3}P, A=Sr,Ca,La, with full consideration of spin-orbit interaction. For SrPt{sub 3}P, the coupling is carried almost totally by a single low-frequency branch consisting of planar Pt vibrations, which result in a coupling constant of λ∼2. In CaPt{sub 3}P this mode stiffens significantly thereby reducing λ to about 1, while in LaPt{sub 3}P the coupling is further reduced to 0.5 because of a shift of the electronic bands. In contrast to previous work, our ab initio results provide a consistent quantitative description of the key features of superconductivity in this new class of materials within the framework of the strong-coupling Eliashberg theory.

  10. Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch.

    Maria Poulou

    Full Text Available BACKGROUND: Present technology uses mostly chimeric proteins as regulators and hormones or antibiotics as signals to induce spatial and temporal gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that a chromosomally integrated yeast 'Leu3p-alpha-IotaRhoMu' system constitutes a ligand-inducible regulatory "off-on" genetic switch with an extensively dynamic action area. We find that Leu3p acts as an active transcriptional repressor in the absence and as an activator in the presence of alpha-isopropylmalate (alpha-IotaRhoMu in primary fibroblasts isolated from double transgenic mouse embryos bearing ubiquitously expressing Leu3p and a Leu3p regulated GFP reporter. In the absence of the branched amino acid biosynthetic pathway in animals, metabolically stable alpha-IPM presents an EC(50 equal to 0.8837 mM and fast "OFF-ON" kinetics (t(50ON = 43 min, t(50OFF = 2.18 h, it enters the cells via passive diffusion, while it is non-toxic to mammalian cells and to fertilized mouse eggs cultured ex vivo. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that the 'Leu3p-alpha-IotaRhoMu' constitutes a simpler and safer system for inducible gene expression in biomedical applications.

  11. Reactions of N+ (3P) ions with H2 and HD molecules at low temperatures

    Grozdanov, Tasko P.; McCarroll, Ronald; Roueff, Evelyne

    2016-04-01

    formation of ND+. The calculated value is consistent with the available experimental data. Conclusions: The present results allow for the determination of reaction rate coefficients for any given distribution of specific fine structure and rotational state populations of the reactants. In interstellar conditions, where N+ is in its 3P0 state and para- and ortho-H2 respectively in J = 0 and J = 1. Our results enable a study of the influence of the ortho/para evolution of molecular hydrogen on the formation of nitrogen compounds.

  12. Regulatory role of the sequences downstream from nodD3 P1 promoter of Rhizobium meliloti

    2000-01-01

    The 660 bp region between nodD3 P1 promoter and the following coding region of Rhizobium meliloti has been studied.This region is designated "downstream sequences".It consists of two potential open reading frames,ORF1 and ORF2.Studies on the role of the downstream sequences on the activity of nodD3 P1 with nod D3(P1)-lacZ fusion show that deletion of the sequences containing ORF2 causes the increase of the activity of the fusion; on the contrary,addition of extra copies of ORF2 markedly decreases the activity of the fusion.These results indicate that the product of ORF2 plays a negative role in the expression of nod D3.

  13. Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.

    Pearce, D A; Nosel, S A; Sherman, F

    1999-04-01

    Although the gene responsible for Batten disease, CLN3, was positionally cloned in 1995, the function of Cln3p and the molecular basis of the disease still remain elusive. We previously reported that the yeast Saccharomyces cerevisiae contains a homolog to Cln3p, designated Btn1p, and that the human Cln3p complemented the pH-dependent resistance to D-(-)-threo-2-amino-1-[p-nitrophenyl]-1, 3-propanediol in btn1-Delta yeast mutants. We have determined that yeast lacking Btn1p have an elevated ability to acidify media during growth that correlates with an elevated plasma membrane ATPase activity. Btn1p may be involved in maintaining pH homeostasis of yeast cells. PMID:10191121

  14. Biomimetic-Inspired Infrared Sensors from Zn3P2 Microwires: Study of Their Photoconductivity and Infrared Spectrum Properties

    M. Israelowitz

    2014-01-01

    Full Text Available The fire beetle, Melanophila acuminata (Coleoptera: Buprestidae, senses infrared radiation at wavelengths of 3 and 10–25 microns via specialized protein-containing sensilla. Although the protein denatures outside of a biological system, this detection mechanism has inspired our bottom-up approach to produce single zinc phosphide microwires via vapour transport for IR sensing. The Zn3P2 microwires were immobilized and electrical contact was made by dielectrophoresis. Photoconductivity measurements have been extended to the near IR range, spanning the Zn3P2 band gaps. Purity and integrity of the Zn3P2 microwires including infrared light scattering properties were confirmed by infrared transmission microscopy. This biomimetic microwire shows promise for infrared chip development.

  15. Doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions in Debye plasmas

    Hu, Xiao-Qing; Wang, Yang; Kar, Sabyasachi, E-mail: skar@hit.edu.cn, E-mail: karsabyasachi@yahoo.com [Center for Theoretical Atomic and Molecular Physics, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080 (China); Jiang, Zishi [College of Physical Science and Technology, Heilongjiang University, Harbin 150080 (China); Jiang, Pinghui [College of Electrical and Information Engineering, Heilongjiang Institute of Technology, Harbin 150050 (China)

    2015-11-15

    We investigate the doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions Li{sup +}, Be{sup 2+}, B{sup 3+}, and C{sup 4+} by employing correlated exponential wave functions. In the framework of the stabilization method, we calculate two series (3pnp and 3dnd) of {sup 3}P{sup e} resonances below the N = 3 threshold. The {sup 3}P{sup e} resonance parameters (resonance energies and widths) are reported for the first time as a function of the screening parameter. For free-atomic cases, comparisons are made with the reported results and few resonance states are reported for the first time.

  16. Na*(3p)-Formation under grazing scattering of Na[sup +]-ions at an Al(111) surface

    Zimny, R. (Inst. fuer Kernphysik, Univ. Muenster (Germany)); Borisov, A.G. (Dept. of Physics, Moscow State Univ. (Russian Federation))

    1994-06-01

    Excited Na*(3p)-atoms are observed in grazing surface-collision experiments with Na[sup +]-beams. Such atoms can be formed beyond a certain threshold velocity via resonant electron transfer between atomic and metallic conduction band levels due to motion of the atom relative to the surface of the metal (''kinematic resonance''). This mechanism is studied here theoretically employing two different techniques: the nonperturbative ''Coupled Angular Mode'' (CAM) method and the approximate ''Transfer Hamiltonian'' (TH) method. The calculated Na*(3p)-populations agree well with recent experimental results. Moreover, the complete density matrix of the Na*(3p)-subspace has been computed with the TH-method for ion-energies between 10 and 300 keV. (orig.)

  17. Frontobasal gray matter loss is associated with the TREM2 p.R47H variant.

    Luis, Elkin O; Ortega-Cubero, Sara; Lamet, Isabel; Razquin, Cristina; Cruchaga, Carlos; Benitez, Bruno A; Lorenzo, Elena; Irigoyen, Jaione; Pastor, Maria A; Pastor, Pau

    2014-12-01

    A rare heterozygous TREM2 variant p.R47H (rs75932628) has been associated with an increased risk for Alzheimer's disease (AD). We aimed to investigate the clinical presentation, neuropsychological profile, and regional pattern of gray matter and white matter loss associated with the TREM2 variant p.R47H, and to establish which regions best differentiate p.R47H carriers from noncarriers in 2 sample sets (Spanish and Alzheimer's Disease Neuroimaging Initiative, ADNI1). This was a cross-sectional study including a total number of 16 TREM2 p.R47H carriers diagnosed with AD or mild cognitive impairment, 75 AD p.R47H noncarriers and 75 cognitively intact TREM2 p.R47H noncarriers. Spanish AD TREM2 p.R47H carriers showed apraxia (9 of 9) and psychiatric symptoms such as personality changes, anxiety, paranoia, or fears more frequently than in AD noncarriers (corrected p = 0.039). For gray matter and white matter volumetric brain magnetic resonance imaging voxelwise analyses, we used statistical parametric mapping (SPM8) based on the General Linear Model. We used 3 different design matrices with a full factorial design. Voxel-based morphometry analyses were performed separately in the 2 sample sets. The absence of interset statistical differences allowed us to perform joint and conjunction analyses. Independent voxel-based morphometry analysis of the Spanish set as well as conjunction and joint analyses revealed substantial gray matter loss in orbitofrontal cortex and anterior cingulate cortex with relative preservation of parietal lobes in AD and/or mild cognitive impairment TREM2 p.R47H carriers, suggesting that TREM2 p.R47H variant is associated with certain clinical and neuroimaging AD features in addition to the increased TREM2 p.R47H atrophy in temporal lobes as described previously. The high frequency of pathologic behavioral symptoms, combined with a preferential frontobasal gray matter cortical loss, suggests that frontobasal and temporal regions could be more

  18. Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.

    Raphaël Bourgeas

    Full Text Available BACKGROUND: In the last decade, the inhibition of protein-protein interactions (PPIs has emerged from both academic and private research as a new way to modulate the activity of proteins. Inhibitors of these original interactions are certainly the next generation of highly innovative drugs that will reach the market in the next decade. However, in silico design of such compounds still remains challenging. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe this particular PPI chemical space through the presentation of 2P2I(DB, a hand-curated database dedicated to the structure of PPIs with known inhibitors. We have analyzed protein/protein and protein/inhibitor interfaces in terms of geometrical parameters, atom and residue properties, buried accessible surface area and other biophysical parameters. The interfaces found in 2P2I(DB were then compared to those of representative datasets of heterodimeric complexes. We propose a new classification of PPIs with known inhibitors into two classes depending on the number of segments present at the interface and corresponding to either a single secondary structure element or to a more globular interacting domain. 2P2I(DB complexes share global shape properties with standard transient heterodimer complexes, but their accessible surface areas are significantly smaller. No major conformational changes are seen between the different states of the proteins. The interfaces are more hydrophobic than general PPI's interfaces, with less charged residues and more non-polar atoms. Finally, fifty percent of the complexes in the 2P2I(DB dataset possess more hydrogen bonds than typical protein-protein complexes. Potential areas of study for the future are proposed, which include a new classification system consisting of specific families and the identification of PPI targets with high druggability potential based on key descriptors of the interaction. CONCLUSIONS: 2P2I database stores structural information about PPIs

  19. BOT3P: a mesh generation software package for transport analysis with deterministic and Monte Carlo codes

    BOT3P consists of a set of standard Fortran 77 language programs that gives the users of the deterministic transport codes DORT, TORT, TWODANT, THREEDANT, PARTISN and the sensitivity code SUSD3D some useful diagnostic tools to prepare and check the geometry of their input data files for both Cartesian and cylindrical geometries, including graphical display modules. Users can produce the geometrical and material distribution data for all the cited codes for both two-dimensional and three-dimensional applications and, only in 3-dimensional Cartesian geometry, for the Monte Carlo Transport Code MCNP, starting from the same BOT3P input. Moreover, BOT3P stores the fine mesh arrays and the material zone map in a binary file, the content of which can be easily interfaced to any deterministic and Monte Carlo transport code. This makes it possible to compare directly for the same geometry the effects stemming from the use of different data libraries and solution approaches on transport analysis results. BOT3P Version 5.0 lets users optionally and with the desired precision compute the area/volume error of material zones with respect to the theoretical values, if any, because of the stair-cased representation of the geometry, and automatically update material densities on the whole zone domains to conserve masses. A local (per mesh) density correction approach is also available. BOT3P is designed to run on Linux/UNIX platforms and is publicly available from the Organization for Economic Cooperation and Development (OECD/NEA)/Nuclear Energy Agency Data Bank. Through the use of BOT3P, radiation transport problems with complex 3-dimensional geometrical structures can be modelled easily, as a relatively small amount of engineer-time is required and refinement is achieved by changing few parameters. This tool is useful for solving very large challenging problems, as successfully demonstrated not only in some complex neutron shielding and criticality benchmarks but also in a power

  20. Lifetime measurement of the metastable 2{sup 3}P{sub 0} state in He-like uranium

    Toleikis, S. [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., MS 88R0192, Berkeley, CA 94720-8101 (United States) and Texas A and M University, College Station, TX (United States)]. E-mail: stoleikis@lbl.gov; Manil, B. [GANIL, Caen (France); Bednarz, G. [IFUJ, Cracow (Poland); Berdermann, E. [GSI, Darmstadt (Germany); Beyer, H.F. [GSI, Darmstadt (Germany); Bosch, F. [GSI, Darmstadt (Germany); Braeuning-Demian, A. [GSI, Darmstadt (Germany); Gumberidze, A. [GSI, Darmstadt (Germany); Indelicato, P. [Universite P. et M. Curie, Paris (France); Kozhuharov, C. [GSI, Darmstadt (Germany); Liesen, D. [GSI, Darmstadt (Germany); Marrus, R. [University of California, Berkeley, CA (United States); Mokler, P.H. [GSI, Darmstadt (Germany); Stachura, Z. [INP, Cracow (Poland); Stoehlker, T. [GSI, Darmstadt (Germany); Warczak, A. [IFUJ, Cracow (Poland)

    2005-07-01

    The lifetime of the 2{sup 3}P{sub 0} state in He-like uranium has been measured in a beam-foil time-of-flight experiment at the Gesellschaft fur Schwerionenforschung accelerator facility with the result {tau}(2{sup 3}P{sub 0})=58.2(9.5)ps. With the measured lifetime it is possible to derive a value of {delta}E{sub 2s}{sup Lamb}=76.3+/-20.6eV for the n=2 Lamb shift in uranium.

  1. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

    Gross, Andrew M.; Ryan K. Orosco; Shen, John P.; Egloff, Ann Marie; Carter, Hannah; Hofree, Matan; Choueiri, Michel; Charles S. Coffey; Lippman, Scott M.; Hayes, D. Neil; Cohen, Ezra E.; Grandis, Jennifer R.; Nguyen, Quyen T.; Ideker, Trey

    2014-01-01

    Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a propensity for metastasis and recurrence. Here we report a comprehensive analysis of the molecular and clinical features of HNSCC that govern patient survival. We find that TP53 mutation is frequently accompanied by loss of chromosome 3p, and that the combination of both events associates with a surprising decrease in survival rates (1.9 years versus >5 years for TP53 mutation alone). The TP53-3p inte...

  2. Spectroscopy of 1S0- 3P1 transition of magnesium atom in an external absorption cell

    Bagayev, S. N.; Baraulya, V. I.; Bonert, A. E.; Goncharov, A. N.; Seydaliev, M. R.

    2001-09-01

    The results of saturated absorption spectroscopy of the intercombination 1S0- 3P1 transition of magnesium atoms at 457 nm in an external absorption cell are presented. A laser system based on a Ti:Sa laser with frequency doubling in a LBO nonlinear crystal was used in these experiments. Saturated absorption resonances of magnesium in an external cell at the 1S0- 3P1 transition have been obtained for the first time. Pressure broadening of resonances equal to 12.5±1.5 kHz/mTorr has been measured.

  3. 'Oxygen' effect in ionization loss spectrum of Cu3p in YBa2Cu3Ox ceramics

    YBaCu3Ox ceramic samples with different oxygen concentration (6.2; 6.5 and 6.9) in a volume are investigated. The process of degradation of samples with high X in the vacuum is analyzed. The surface purification is performed through scribing in argon atmosphere. A new effect is ascertained which is manifested in high sensitivity of Cu3p ionization loss spectrum to the density of the non-occupied electron states at the Fermi level. It is shown that Cu3p ionization spectrum can serve as a new criterion of superconductor surface quality from the viewpoint of its electronic structure

  4. Alterations of N-3 Polyunsaturated Fatty Acid-Activated K2P Channels in Hypoxia-Induced Pulmonary Hypertension

    Nielsen, Gorm; Wandall-Frostholm, Christine; Sadda, Veeranjaneyulu; Oliván-Viguera, Aida; Lloyd, Eric E.; Bryan, Robert M.; Simonsen, Ulf; Köhler, Ralf

    2013-01-01

    Polyunsaturated fatty acid (PUFA)-activated two-pore domain potassium channels (K2P) have been proposed to be expressed in the pulmonary vasculature. However, their physiological or pathophysiological roles are poorly defined. Here we tested the hypothesis that PUFA-activated K2P are involved in pulmonary vasorelaxation and that alterations of channel expression are pathophysiologically linked to pulmonary hypertension. Expression of PUFA-activated K2P in the murine lung was investigated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR), immunohistochemistry (IHC), by patch clamp (PC), and myography. K2P-gene expression was examined in chronic hypoxic mice. QRT-PCR showed that the K2P2.1 and K2P6.1 were the predominantly expressed K2P in the murine lung. IHC revealed protein expression of K2P2.1 and K2P6.1 in the endothelium of pulmonary arteries and of K2P6.1 in bronchial epithelium. PC showed pimozide-sensitive K2P-like K+-current activated by docosahexaenoic acid (DHA) in freshly isolated endothelial cells as well as DHA-induced membrane hyperpolarization. Myography on pulmonary arteries showed that DHA-induced concentration-dependent and instantaneous relaxations that were resistant to endothelial removal and inhibition of NO and prostacyclin synthesis and to a cocktail of blockers of calcium-activated K+ channels but were abolished by high extracellular (30 mM) K+-concentration. Gene expression and protein of K2P2.1 were not altered in chronic hypoxic mice while K2P6.1 was up-regulated by fourfold. In conclusion, the PUFA-activated K2P2.1 and K2P6.1 are expressed in murine lung and functional K2P-like channels contribute to endothelium-hyperpolarization and pulmonary artery relaxation. The increased K2P6.1-gene expression may represent a novel counter-regulatory mechanism in pulmonary hypertension, and suggest that arterial K2P2.1 and K2P6.1 could be novel therapeutic targets. PMID:23724868

  5. High lying energy positions of doubly (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} excited states of the beryllium atom

    Sakho, I., E-mail: aminafatima_sakho@yahoo.fr [UFR Sciences and Technologies, Department of physics, University of Ziguinchor, Ziguinchor (Senegal)

    2011-12-15

    The Screening Constant by Unit Nuclear Charge (SCUNC) method is used to study (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} autoionizing states of the beryllium atom. Energy positions are reported up to n=20. In addition, resonance widths of the (2pns) {sup 1}P{sup o} states also presented. The current results compared very well to available theoretical and experimental literature values up to n=15. The accurate data presented in this work may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be. - Highlights: > Accurate energy positions of (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} (n=3-20) autoionizing states of Be atoms. > Currently results compared very well to theoretical and experimental literature values up to n=15. > Presently data may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be.

  6. Experimental transition probabilities of the intercombination line 1s2ws21S0-1s22s3p3P01 in Be-like ions of Na through Si

    The decay of the 1s22s3p3 Po0,1,2 levels in Be-like ions of Na, Mg, Al and Si has been investigated using the beam-foil method. The mean wavelengths of the transition 1s22p23P0,1,2-1s22s3p 3Po0,1,2 and the lifetimes of the 1s22s3p 3Po0,1,2 levels have been measured. An intercomparison of these lifetimes yields the transition probability of the intercombination line 1s22s21S0-1s22s3p 3Po1. The results are (3.45 ± 0.73) 109 s-1 in Na VIII, (5.55 ± 0.96) 109 s-1 in Mg IX, (1.21 ± 0.24) 1010 s-1 in Al X and (2.50 ± 0.54) 1010 s-1 in Si XI. (orig.)

  7. The System Design of a Node of P2P Networks for Intrusion Detection

    Lei Ding

    2013-08-01

    Full Text Available To improve the measuring accuracy of intrusion detection, a system design of a node for intrusion detection is proposed in this paper. First, the technology that applies the traditional intrusion detection method, such as anomaly detection and misuse detection, into P2P networks is presented. Next, to build the trust relationship among the nodes, and realize the cooperation mechanism of data detection, collection and response among the nodes of P2P networks, the corresponding solving plans, such as topological structure, trust model, information share and information fusion, are proposed in this paper. Then the concept of network telescope is presented to broaden the field of vision of malicious attacks and abnormal network packets in the propagation path. Finally, a system design of a node for intrusion detection using the honeypot technology is proposed in this paper.

  8. n-p short-range correlations from (p,2p+n) measurements.

    Tang, A; Watson, J W; Aclander, J; Alster, J; Asryan, G; Averichev, Y; Barton, D; Baturin, V; Bukhtoyarova, N; Carroll, A; Gushue, S; Heppelmann, S; Leksanov, A; Makdisi, Y; Malki, A; Minina, E; Navon, I; Nicholson, H; Ogawa, A; Panebratsev, Yu; Piasetzky, E; Schetkovsky, A; Shimanskiy, S; Zhalov, D

    2003-01-31

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events p(f), the momentum of the knocked-out proton before the reaction, was compared (event by event) with p(n), the coincident neutron momentum. For |p(n)|>k(F)=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between p(f) and p(n) was observed, indicative of short-range n-p correlations. From p(n) and p(f) we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49+/-13% of events with |p(f)|>k(F) had directionally correlated neutrons with |p(n)|>k(F). PMID:12570411

  9. n-p Short-Range Correlations from (p,2p + n) Measurements

    Tang, A.; Watson, J. W.; Aclander, J.; Alster, J.; Asryan, G.; Averichev, Y.; Barton, D; Baturin, V.; Bukhtoyarova, N.; Carroll, A.; Heppelmann, S.; Leksanov, A.; Makdisi, Y.; Malki, A.; Minina, E.

    2002-01-01

    We studied the $^{12}$C(p,2p+n) reaction at beam momenta of 5.9, 8.0 and 9.0 GeV/c. For quasielastic (p,2p) events we reconstructed {\\bf p_f} the momentum of the knocked-out proton before the reaction; {\\bf p_f} was then compared (event-by-event) with {\\bf p_n}, the measured, coincident neutron momentum. For $|p_n|$ > k$_F$ = 0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between {\\bf p_f} and {\\bf p_n} was observed, indicative of short-range n-p correlations. ...

  10. IP2P K-means: an efficient method for data clustering on sensor networks

    Peyman Mirhadi

    2013-03-01

    Full Text Available Many wireless sensor network applications require data gathering as the most important parts of their operations. There are increasing demands for innovative methods to improve energy efficiency and to prolong the network lifetime. Clustering is considered as an efficient topology control methods in wireless sensor networks, which can increase network scalability and lifetime. This paper presents a method, IP2P K-means – Improved P2P K-means, which uses efficient leveling in clustering approach, reduces false labeling and restricts the necessary communication among various sensors, which obviously saves more energy. The proposed method is examined in Network Simulator Ver.2 (NS2 and the preliminary results show that the algorithm works effectively and relatively more precisely.

  11. A Potential Approach of Internet Worm Propagation Based on P2P

    YAO Yu; LUO Xingrui; GAO Fuxiang; YU Ge

    2006-01-01

    Various kinds of active worms have been plunging into the network flows, which make the Internet security problem more serious. Our research on a potential propagation approach of active worms, P2P-based propagation approach, is given in this paper. To measure the propagating performance of our approach, the SEI (Susceptible-Exposed- Infected) propagation model is presented. It proves that with the idea of pure P2P architecture, worms can be hidden in the early stage of propagation, and then infect most of the hosts in a shorter period. By comparing our SEI propagation model with the Simple Epidemic Model, we observe that the size of a worm is a significant parameter which can affect the propagating performance. When the size of the worm becomes large, our approach can still show an excellent propagating performance.

  12. PISA: Federated Search in P2P Networks with Uncooperative Peers

    Ren, Zujie; Shou, Lidan; Chen, Gang; Chen, Chun; Bei, Yijun

    Recently, federated search in P2P networks has received much attention. Most of the previous work assumed a cooperative environment where each peer can actively participate in information publishing and distributed document indexing. However, little work has addressed the problem of incorporating uncooperative peers, which do not publish their own corpus statistics, into a network. This paper presents a P2P-based federated search framework called PISA which incorporates uncooperative peers as well as the normal ones. In order to address the indexing needs for uncooperative peers, we propose a novel heuristic query-based sampling approach which can obtain high-quality resource descriptions from uncooperative peers at relatively low communication cost. We also propose an effective method called RISE to merge the results returned by uncooperative peers. Our experimental results indicate that PISA can provide quality search results, while utilizing the uncooperative peers at a low cost.

  13. Kinetic Energy Distribution of H(2p) Atoms from Dissociative Excitation of H2

    Ajello, Joseph M.; Ahmed, Syed M.; Kanik, Isik; Multari, Rosalie

    1995-01-01

    The kinetic energy distribution of H(2p) atoms resulting from electron impact dissociation of H2 has been measured for the first time with uv spectroscopy. A high resolution uv spectrometer was used for the measurement of the H Lyman-alpha emission line profiles at 20 and 100 eV electron impact energies. Analysis of the deconvolved 100 eV line profile reveals the existence of a narrow line peak and a broad pedestal base. Slow H(2p) atoms with peak energy near 80 meV produce the peak profile, which is nearly independent of impact energy. The wings of H Lyman-alpha arise from dissociative excitation of a series of doubly excited Q(sub 1) and Q(sub 2) states, which define the core orbitals. The fast atom energy distribution peaks at 4 eV.

  14. Predicting the Impact of Measures Against P2P Networks on the Transient Behaviors

    Altman, Eitan; Shwartz, Adam; Xu, Yuedong

    2010-01-01

    The paper has two objectives. The first is to study rigorously the transient behavior of some P2P networks where information is replicated and disseminated according to an epidemic type dynamics. The second is to use the insight gained in order to predict how efficient are measures taken against peer to peer networks. We first study a model which extends a classical epidemic model to characterize the peer to peer swarms in the presence of free riding peers. We then study a second model that a peer initiates a contact with another peer chosen randomly. In both cases, the network is shown to have a phase transition: a small change in the parameters causes a large change in the behavior of the network. We show in particular how the phase transition affects measures that content provider networks may take against P2P networks that distribute non-authorized music or books, and what is the efficiency of counter-measures.

  15. Structure of β-TlMo2P3O13

    Thallium molybdenum triphosphate, TlMo2P3O13, Mr=679.16, monoclinic, P21/c, a=9.7536 (3), b=19.0640 (16), c=6.3945 (7) A, β=107.099 (7)0, V=1136 (2) A3, Z=4, Dm not measured, Dx=4.08 Mg m-3, λ(MoKα)=0.71073 A, μ=16.90 mm-1, F(000)=314, T=293 K, 951 reflections, R=0.047, ωR=0.047. The lattice is built up from MoO6, PO4 and P2O7 groups delimiting tunnels where the Tl+ ions are located. The title compound is isotyopic with β-KMo2P3O13. (orig.)

  16. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase

    Wang, Wenzhong; Winther, Jakob R; Thorpe, Colin

    2007-01-01

    centers that facilitate the transfer of reducing equivalents from the dithiol substrates of these oxidases to the isoalloxazine ring where the reaction with molecular oxygen occurs. The present study examines yeast Erv2p and compares the redox behavior of this ER luminal protein with the augmenter of...... unfolded proteins. Rapid reaction studies confirm that reduction of the flavin center of Erv2p is rate-limiting during turnover with molecular oxygen. This comparison of the redox properties between members of the ERV/ALR family of sulfhydryl oxidases provides insights into their likely roles in oxidative......The FAD prosthetic group of the ERV/ALR family of sulfhydryl oxidases is housed at the mouth of a 4-helix bundle and communicates with a pair of juxtaposed cysteine residues that form the proximal redox active disulfide. Most of these enzymes have one or more additional distal disulfide redox...

  17. Tatton-Brown-Rahman syndrome due to 2p23 microdeletion.

    Okamoto, Nobuhiko; Toribe, Yasuhisa; Shimojima, Keiko; Yamamoto, Toshiyuki

    2016-05-01

    Tatton-Brown-Rahman syndrome is a new overgrowth syndrome due to DNMT3A (DNA cytosine 5 methyltransferase 3A) mutations. Mutation carriers show a distinctive facial appearance, intellectual disability, and increased height. We report a patient with overgrowth who showed submicroscopic deletion of chromosome 2p23 including DNMT3A. The deletion was detected by array-CGH. He showed moderate ID and distinctive facial gestalt. His clinical features were consistent with those of Tatton-Brown-Rahman syndrome. We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth. © 2016 Wiley Periodicals, Inc. PMID:26866722

  18. Using of P2P Networks for Acceleration of RTE Tasks Solving

    Adrian Iftene

    2008-07-01

    Full Text Available In the last years the computational Grids have become an important research area in large-scale scientific and engineering research. Our approach is based on Peer-to-peer (P2P networks, which are recognized as one of most used architectures in order to achieve scalability in key components of Grid systems. The main scope in using of a computational Grid was to improve the computational speed of systems that solve complex problems from Natural Language processing field. We will see how can be implemented a computational Grid using the P2P model, and how can be used SMB protocol for file transfer. After that we will see how we can use this computational Grid, in order to improve the computational speed of a system used in RTE competition [1], a new complex challenge from Natural Language processing field.

  19. A Fuzzy Reputation Management System with Punishment Mechanism for P2P Network

    Zhengbing Hu

    2011-02-01

    Full Text Available One way to minimize threats in P2P system is to exploit reputation to help evaluate the trustworthiness and predict the future behaviors of peers. In this paper, a set of parameters are identified for describing the trust of a peer. And a trust model based on fuzzy techniques is presented. The trust model uses Amplifier of Malicious Behavior (AMB to intensify malicious behaviors and helps peers identify the sly malicious peers. The recommendation credibility is evaluated by Recommendation Weight (RW and Recommendation Accuracy (RA. In simulation, this trust model has been shown to improve the efficiency of P2P system by significantly decreasing the number of inauthentic files on the network.

  20. n-p Short-Range Correlations from (p,2p+n) Measurements

    Tang, A.; Watson, J. W.; Aclander, J.; Alster, J.; Asryan, G.; Averichev, Y.; Barton, D.; Baturin, V.; Bukhtoyarova, N.; Carroll, A.; Gushue, S.; Heppelmann, S.; Leksanov, A.; Makdisi, Y.; Malki, A.; Minina, E.; Navon, I.; Nicholson, H.; Ogawa, A.; Panebratsev, Yu.; Piasetzky, E.; Schetkovsky, A.; Shimanskiy, S.; Zhalov, D.

    2003-01-01

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events pf, the momentum of the knocked-out proton before the reaction, was compared (event by event) with pn, the coincident neutron momentum. For |pn|>kF=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between pf and pn was observed, indicative of short-range n-p correlations. From pn and pf we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49±13% of events with |pf|>kF had directionally correlated neutrons with |pn|>kF.

  1. Towards a P2P-Based Deployment of Network Management Information

    Makhloufi, Rafik; Bonnet, Grégory; Doyen, Guillaume; Gaïti, Dominique

    2010-01-01

    International audience Standard static centralized network management approaches are unsuitable for managing large, dynamic and distributed networks. Some decentralized approaches based on the P2P model have emerged to overcome the limitations of these centralized approaches like lack of scalability and fault-tolerance. However, they do not address issues related to the deployment of management information which is crucial in a decentralized management context because of the heterogeneous ...

  2. Magnetic and Magnetocaloric Exploration of Fe rich (Mn,Fe)2(P,Ge)

    Leitao, J. V.; Haar, M. van der; Lefering, A.; Bruck, E.

    2013-01-01

    We explored the Fe rich side of the (Mn,Fe)2(P,Ge) magnetocaloric system. The transition temperature of this system is extremely easy to tune with careful manipulation of Fe and Ge content as well as stoichiometrical proportions, which gives rise to the real possibility of lowering the price of this compound and thus make it economically viable for practical magnetocaloric applications. Novel and unexpected magnetic properties observed in this system suggest an exciting potential for permanen...

  3. A lightweight distributed super peer election algorithm for unstructured dynamic P2P systems

    Henriques, Pedro Manuel dos Santos

    2011-01-01

    Nowadays with the current growth of information exchange, and the increasing mobility of devices, it becomes essential to use technology to monitor this development. For that P2P networks are used, the exchange of information between agencies is facilitated, these now being applied in mobile networks, including MANETs, where they have special features such as the fact that they are semi-centralized, where it takes peers more ability to make a greater role in the network. But those peer with m...

  4. Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis

    Dostál, Jiří; Pecina, Adam; Hrušková-Heidingsfeldová, Olga; Marečková, L.; Pichová, Iva; Řezáčová, Pavlína; Lepšík, Martin; Brynda, Jiří

    2015-01-01

    Roč. 71, č. 12 (2015), s. 2494-2504. ISSN 1399-0047 R&D Projects: GA ČR(CZ) GA14-23022S Institutional support: RVO:61388963 ; RVO:68378050 Keywords : aspartic protease * Candida parapsilosis * Sapp2p * crystal structure * ultrahigh resolution * interaction energy * quantum mechanics Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J) Impact factor: 2.674, year: 2014

  5. Personalized Trust Management for Open and Flat P2P Communities

    ZUO Min; LI Jian-hua

    2008-01-01

    A personalized trust management scheme is proposed to help peers build up trust between each other in open and flat P2P communities. This scheme totally abandons the attempt to achieve a global view. It evaluates trust from a subjective point of view and gives personalized decision support to each peer. Simulation experiments prove its three advantages: free of central control, stronger immunity to misleading recommendations, and limited traffic overload.

  6. Photocatalytic degradation of trimethoprim by metallic nanoparticles supported on TiO2-P25

    Highlights: • Photoactivity of TiO2 modified with metal NP evaluated in the degradation of trimethoprim. • The modification of TiO2 by gold and silver increases the mineralization of organic matter up to 80%. • The first study on the photocatalytic degradation of trimethoprim using TiO2 modified with metal NP. -- Abstract: The effect of Au, Ag, Cu and Ni nanoparticles deposited on TiO2-P25 was studied on the photodegradation of trimethoprim, a commonly used antibiotic. The synthesized materials were characterized by ICP, EDS, XRD, BET, UV–vis, TEM and TPR. The metal loading was 0.5 wt.% and the average particle size was about 2 nm in all the studied samples. The deposition of metallic particles on TiO2-P25 produces an enhancement of the activity of the bare semiconductor; when the degradation of trimethoprim was carried out by pure TiO2-P25, the mineralization reached only 50% of the organic matter, while by using metallic nanoparticles deposited on TiO2-P25, the mineralization of organic matter increased up to 80% for the same reaction conditions and reaction time. The evaluation of the photocatalytic activity was made for solutions containing trimethoprim in concentrations of 40 ppm under UV light irradiation using a lamp with primary emission at 254 nm and 2.2 mW/cm2. It is shown that the ability of the photocatalyst to mineralize trimethoprim depends on the electron affinity and the electronegativity of the deposited metal

  7. Protocols for Bio-Inspired Resource Discovery and Erasure Coded Replication in P2P Networks

    Thampi, Sabu M

    2010-01-01

    Efficient resource discovery and availability improvement are very important issues in unstructured P2P networks. In this paper, a bio-inspired resource discovery scheme inspired by the principle of elephants migration is proposed. A replication scheme based on Q-learning and erasure codes is also introduced. Simulation results show that the proposed schemes significantly increases query success rate and availability, and reduces the network traffic as the resources are effectively distributed to well-performing nodes.

  8. csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation

    Costa, Judite; Fu, Chuanhai; Khare, V. Mohini; Tran, Phong T.

    2014-01-01

    Proper chromosome segregation is of paramount importance for proper genetic inheritance. Defects in chromosome segregation can lead to aneuploidy, which is a hallmark of cancer cells. Eukaryotic chromosome segregation is accomplished by the bipolar spindle. Additional mechanisms, such as the spindle assembly checkpoint and centromere positioning, further help to ensure complete segregation fidelity. Here we present the fission yeast csi2 +. csi2p localizes to the spindle poles, where it regul...

  9. Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel

    Podaralla, Satheesh; Alt, Carsten; Shankar, Gita N.

    2014-01-01

    The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal s...

  10. RIAPPA: a robust identity assignment protocol for P2P overlays

    Caubet Fernández, Juan; Esparza Martín, Óscar; Muñoz Tapia, José Luis; Alins Delgado, Juan José; Mata Diaz, Jorge

    2014-01-01

    Peer-to-peer (P2P) overlay networks have been proposed to solve routing problems of big distributed infrastructures, even for Internet scale. But the research community has been questioning the security of these networks for years. Most prior work in security services was focused on trust and reputation systems, anonymity, and secure routing. However, the proper management of identities in overlays is an important prerequisite to provide most of these security services. In this paper, we prop...

  11. Relativistic calculations of 1s22s2p level splitting in Be-like Kr

    High-precision calculations of 1s22s2p excited energy levels in Be-like Kr isotopes are presented using the multi-configuration Dirac–Fock approach. The calculations include QED corrections and electron correlation including all single and double excitations up to n = 5 orbitals. Breit interaction and vacuum polarization were included to all orders in the self-consistent process. Effects of isotopic mass shifts and hyperfine corrections for 83Kr are discussed. (paper)

  12. A population dynamics model for data streaming over P2P networks

    Xu, J.; Yang, G.; Li, VOK

    2009-01-01

    Data streaming (DS) over Peer-to-Peer (P2P) networks has been intensively studied in recent years and there have been various schemes proposed already. To evaluate these schemes, either measurement in experimental implementations, or simulation and theoretical analysis have been used. The former is inadequate as data are collected from different experiments, while the latter lacks a proper theoretical dynamics model. Our research aims at providing a general theoretical model to evaluate DS ov...

  13. Punctuated duplication seeding events during the evolution of human chromosome 2p11

    Horvath, Julie E.; Gulden, Cassandra L.; Vallente, Rhea U.; Eichler, Marla Y; Ventura, Mario; McPherson, John D.; Graves, Tina A.; Wilson, Richard K.; Schwartz, Stuart; Rocchi, Mariano; Eichler, Evan E.

    2005-01-01

    Primate genomic sequence comparisons are becoming increasingly useful for elucidating the evolutionary history and organization of our own genome. Such studies are particularly informative within human pericentromeric regions—areas of particularly rapid change in genomic structure. Here, we present a systematic analysis of the evolutionary history of one ∼700-kb region of 2p11, including the first autosomal transition from pericentromeric sequence to higher-order α-satellite DNA. We show that...

  14. Pionic 2p-1s X-ray transitions in 19F and 23Na

    Pi-atomic 2p-1s transitions have been studied in 19F and 23Na. The measured energies are 195.17 +-0.16 and 275.75 +- 0.26 keV, and the Lorentzian full-widths at half-maximum are 10.12 +- 0.74 and 12.0 +- 1.2 keV respectively. A comparison is made with optical model calculations. (Auth.)

  15. Parameterized Adaptive Multidimensional Integration Routines (PAMIR): Localization by Repeated 2^p Subdivision

    Adler, Stephen L.

    2010-01-01

    This book draft gives the theory of a new method for p dimensional adaptive integration by repeated 2^p subdivision of simplexes and hypercubes. A new method of constructing high order integration routines for these geometries permits adjustable samplings of the integration region controlled by user supplied parameters. An outline of the programs and use instructions are also included in the draft. The fortran programs are not included, but will be published with this draft as a book.

  16. Refinement of the critical 2p25.3 deletion region

    De Rocker, Nina; Vergult, Sarah; Koolen, David;

    2015-01-01

    PURPOSE: Submicroscopic deletions of chromosome band 2p25.3 are associated with intellectual disability and/or central obesity. Although MYT1L is believed to be a critical gene responsible for intellectual disability, so far no unequivocal data have confirmed this hypothesis. METHODS: In this stu...... syndromal intellectual disability. Moreover, because 17 patients present with obesity/overweight, haploinsufficiency of MYT1L might predispose to weight problems with childhood onset.Genet Med 17 6, 460-466....

  17. A P2P Service Discovery Strategy Based on Content Catalogues

    Huang, Lican

    2007-01-01

    This paper presents a framework for distributed service discovery based on VIRGO P2P technologies. The services are classified as multi-layer, hierarchical catalogue domains according to their contents. The service providers, which have their own service registries such as UDDIs, register the services they provide and establish a virtual tree in a VIRGO network according to the domain of their service. The service location done by the proposed strategy is effective and guaranteed. This paper ...

  18. JXTA: A Technology Facilitating Mobile P2P Health Management System

    Rajkumar, Rajasekaran; Nallani Chackravatula Sriman, Narayana Iyengar

    2012-01-01

    Objectives Mobile JXTA (Juxtapose) gaining momentum and has attracted the interest of doctors and patients through P2P service that transmits messages. Audio and video can also be transmitted through JXTA. The use of mobile streaming mechanism with the support of mobile hospital management and healthcare system would enable better interaction between doctors, nurses, and the hospital. Experimental results demonstrate good performance in comparison with conventional systems. This study evaluat...

  19. Cross sections for H(2p) formation in slow He{sup 2+}-H collisions

    Higgins, D.P.; Geddes, J.; McCullough, R.W. [The Queen`s Univ. of Belfast (United Kingdom)] [and others

    1994-12-31

    A crossed beam method, previously developed in this laboratory, has been used to study H(2p) formation in He{sup 2+}-H collision by observing the spontaneous emission of Lyman alpha radiation. Measurements at energies below 8 keV amu{sup {minus}1} usefully extend previous higher energy data into an energy range where theoretical predictions are markedly different and exhibit interesting structures which reflect the complexity of the excitation mechanism.

  20. Hyperfine structure constants of the CaII states 4s2S1/2 and 4p2P1/2,3/2 and the nuclear quadrupole moment of 43Ca

    The hyperfine structure splittings of the 4s2S1/2→4p2P1/2,3/2 transitions in 43CaII have been measured by fast ion beam collinear laser spectroscopy. The resonant laser interaction was observed using non-optical detection based on optical ground state depopulation pumping, state selective neutralization and charge state separated particle counting. The extracted magnetic dipole hyperfine structure constants for 43Ca A(2S1/2)=-805(2) MHz, A(2P1/2)=-145.5(1.0) MHz and A(2P3/2)=-31.9(0.2) MHz are in excellent agreement with relativistic many body perturbation theory predictions available for this alkali-like ion. The combined results are used to evaluate the semi-empirical analysis method. From the electrical quadrupole hyperfine structure constant B(2P3/2)=-6.7(1.4) MHz and the calculated B/Q value for this one valance electron configuration, the nuclear quadrupole moment Q(43Ca)=-0.043(9)b is derived. This result supports a previous evaluation based on the hyperfine structure of the two valence electron 3P configurations of CaI. (orig.)