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Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 cells were assessed for clonogenic survival ...

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Peeled Avena sativa coleoptile sections have been used to study the control of solute uptake under conditions where the uptake is not limited by the cuticular barrier. In the presence of 2% sucrose, auxin enhances the rate at which the total osmotic solutes increase, but this appears to be a response to the increased growth rate, inasmuch as the auxin effect is eliminated when growth is inhibited osmotically. When sections are incubated in sucrose or in 10 millimolar NaCl, the osmotic concentration increases until a plateau is reached after 8 to 24 hours. Auxin has no effect on the initial rate of increase in osmotic concentration. This difference in steady-state osmotic concentration is, in part, a response to auxin itself, as it persists when auxin-induced growth is inhibited osmotically. The upper limit for osmotic concentration does not appear to be determined by the turgor pressure, inasmuch as a combination of sucrose ...

International Nuclear Information System (INIS)

One rationale proposals to increase the efficiency of PDT is to combine photo-sensitization with other treatment modalities, including modulation of arachidonic acid metabolism. In combine treatment we examined the effects of 48 h and 24 h pre-treatment of cells with 5- lipoxygenase inhibitor MK-886 prior to photoactivation of hypericin on cell cycle distribution and DNA synthesis. All parameters were examined 24 hours after hypericin activation. Pre-treatment of HT-29 with 5-lipoxygenase inhibitor MK-886 followed by PDT resulted in most significant effects on cell cycle perturbations. Administration of MK-886 alone as well as combination of low doses MK-886 with hypericin induced S phase accumulation. Increasing of MK-886 concentration induced massive changes in the cell cycle progression. Pre-treatment of HT-29 cells with MK-886 alone (15 #mu#M; - 48 h) caused accumulation of ...

Science.gov (United States)

The effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive containing 30 micrograms ethinyl estradiol and 75 micrograms gestodene were assessed in a randomized, double-blind, placebo-controlled parallel-group study in healthy premenopausal female volunteers established in a regimen of oral contraceptive use. They received either placebo or 2400 mg/day felbamate from midcycle (day 15) to midcycle (day 14) of two consecutive oral contraceptive cycles (months 1 and 2). Pharmacokinetic assessments of ethinyl estradiol and gestodene were performed on day 14 of both cycles. To determine whether ovulation occurred, plasma progesterone and urinary luteinizing hormone levels were measured, and diaries recording vaginal bleeding were kept. Felbamate treatment resulted in a significant 42% decrease in gestodene area under the plasma concentration-time curve (0 to 24 hours) (p = 0.018) compared with ...

UK PubMed Central (United Kingdom)

The clinical signs and postmortem findings in sheep from two flocks accidentally poisoned with monensin are described. Clinical signs began within 24 hours of exposure to monensin. In the acute stages...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundA key question in the risk assessment of exposures to multiple chemicals is whether mixture effects may occur when chemicals are combined at low doses which individually...Full Text Available

International Nuclear Information System (INIS)

Patients with Ewing's sarcoma who present with a central axis or proximal extremity primary and/or with metastatic disease have a poor prognosis despite aggressive combination chemotherapy and local irradiation. In this high risk group of patients, total body irradiation (TBI) has been proposed as a systemic adjuvant. To aid in the design of a clinical TBI protocol, the authors have studied in the in vitro radiation response of two established cell lines of Ewing's sarcoma and human bone marrow CFUc. The Ewing's lines showed a larger D_0 and anti-n compared to the bone marrow CFU. No repair of potentially lethal radiation damage (PLDR) was found after 4.5 Gy in plateau phase Ewing's sarcoma cells. A theoretical split dose survival curve for both the Ewing's sarcoma lines and human bone marrow CFUc using this TBI schedule shows a significantly lower surviving fraction (10"-"4-10"-"5) for the bone marrow CFUc. Based on these in vitro results, two 4.0 Gy fractions ...

Science.gov (United States)

The satellite ocean color data record spans multiple decades and, like most long-term satellite

International Nuclear Information System (INIS)

Full text: Many studies have demonstrated significant declines in 24-hour energy expenditure (TEE) measured by whole body calorimetry with either the process of weight loss or the maintenance of reduced body weight. The aims of this study were to determine the effect of weight loss and two weeks of weight maintenance on TEE using ["1"4C]-bicarbonate-urea, Eleven subjects (6 males, 5 females), mean (#+-#SE) age 50 #+-# 3 years, BMI 34.1 #+-# 2.1 kg/m2 and body fat 38.7 #+-# 3% were studied before and after a decrease in body weight of > 8% over a period of 8 weeks, followed by two weeks of weight maintenance. Weight loss was induced using the combination of Modifast and one small meal a day (#approx#3.34 MJ/day). Body composition (DEXA), resting energy expenditure (REE) and the thermic effect of a 2.7 MJ test meal (TEF) were measured in addition to TEE at week 2 and again at week 12. Diet was assessed using diaries and ...

Science.gov (United States)

The effect of spatial auditory information on a listener's ability to detect, identify, and monitor multiple simultaneous speech signals was evaluated using virtual audio technology. Factorial combinations of three variables - the number of localized spee...

UK PubMed Central (United Kingdom)

BackgroundWith the explosion in data generated using microarray technology by different investigators working on similar experiments, it is of interest to combine results across...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The effects of muscarinic agonists and diisopropylfluorophosphate (DFP) on muscarinic receptor density and muscarinic receptor-mediated responses was assessed in mouse brain and mouse neuroblastoma cells (clone N1E-115). Utilizing the antagonist ({sup 3}H)quinuclidinyl benzilate (({sup 3}H)QNB), there was no difference in the maximal binding capacity (B{sub max}) or equilibrium dissociation constant (K{sub d}) between untreated and 24 hour DFP-treated mice. However, one administration of DFP produced a 24% and 33% decrease in B{sub max} measured by ({sup 3}H)N-methylscopolamine (({sup 3}H)NMS) after 18 and 24 hours which was rapidly reversible within 36 hours after DFP treatment. The loss of ({sup 3}H)NMS binding sites following acute DFP treatment was not accompanied by a change in a particular muscarinic receptor binding conformation. Furthermore, the magnitude of muscarinic receptor-mediated ...

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It is built and tested a transition radiation detector (TRD) to discriminate positrons from protons in the balloon flight TS 93 experiment. It is presented the TRD performance using flight data obtaining a proton-positron rejection factor of the order of 10{sup -3}. During the 24 hour flight, the data in the momentum range 4-50 GeV/c are collected. Using the TRD together with the Silicon calorimeter, it is achieved an overall rejection factor of about 10{sup -5} of positron against the proton background over the entire momentum range.

International Nuclear Information System (INIS)

1971 Sorbie et al. described a simple "5"7Co-excretion test (16) as an aid in the diagnosis of iron deficiency anemia. The authors found that renal excretion of a tracer dosis of 0,5 #mu#Ci "5"7CoCl_2 was significantly elevated in patients with iron deficiency anemia (31% of the adminstered dose in 24 hours' urine) as compared with the controls (18%). Between 1972-1974 we performed the "5"7Co-excretion test in 29 patients with different kind of anemia and in 10 healthy volunteers. The test was modified by measurement of the serum activity 1, 2, 3, 7, 11 and 24 hours after the oral administration of the test dosis. In all anemias as well as in the control group we found the maximum of serum activity three hours after the oral administration of the tracer. The three hours serum activity was elevated in patients with iron deficiency anemia (5.53%/l serum) as compared with the control group (1.92%/l) and ...

International Nuclear Information System (INIS)

We report the case of a 22-year-old man with Ewing's sarcoma who attained a complete remission (CR) after combination radiotherapy and chemotherapy. Secondary acute lymphoblastic leukemia with multiple cytogenetic abnormalities involving chromosome 5 and 7 developed 16 years later. The patient underwent induction chemotherapy and entered a CR. Peripheral blood stem cell transplantation from a matched sibling was performed successfully and he is in complete remission of both ALL and Ewing's sarcoma. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

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The objective of this project is to develop improved seismic event location techniques that can be used to generate more and better quality reference events using data from local and regional seismic networks. Their approach is to extend existing methods of multiple-event location with more general models of the errors affecting seismic arrival time data, including picking errors and errors in model-based travel-times (path corrections). Toward this end, they are integrating a grid-search based algorithm for multiple-event location (GMEL) with a new parameterization of travel-time corrections and new kriging method for estimating the correction parameters from observed travel-time residuals. Like several other multiple-event location algorithms, GMEL currently assumes event-independent path corrections and is thus restricted to small event clusters. The new parameterization assumes that travel-time corrections are a ...

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My assignment on the SP-100 Vacuum Vessel Vacuum System Team was to perform a transient pump down analysis for the vacuum vessel that will house the SP-100 reactor during testing. Pump down time was calculated for air and helium. For all cases the proposed vacuum system will be able to pump down the vessel within the required time. The use of a larger rotary piston pump (DUO250) improves the pump down time by 35 minutes and therefore should be considered. The 6-inch duct for the roughing line is optimal, however, because all cases are well below the 24 hour time frame, the 4-inch duct is sufficient. The use of the single turbomolecular pump during pump down is sufficient. A pump down with helium in the vessel and a helium inleakage delays the time to achieve the base pressure marginally and is acceptable.

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Background.There are no suitably powered epidemiological studies of `transient azotaemia' (TA). The objective of this study was to describe the epidemiology of TA and its independent association with hospital mortality. We hypothesized that TA would be associated with an independent increase in the risk of death. Methods.We retrospectively studied all patients admitted to a university-affiliated hospital in Australia between January 2000 and December 2002. Patients were excluded if they were <15 years old, were on chronic dialysis, had kidney transplant or if their length of hospital stay was <24 hours. We defined TA as rapidly recovering acute kidney injury (AKI) (return to no-AKI risk, injury, failure, loss, end stage (RIFLE) class within 72 hours of onset). We performed descriptive and ...

International Nuclear Information System (INIS)

In the present investigation, the properties of plasma nitrided AISI 304 steel were studied by changing the presence of nitrogen in the gas mixture. The plasma nitriding was performed at temperature -560 deg C, pressure -4 mbar and duration 24 hours. The nitrided samples were characterized by evaluating the phase composition, micro hardness, and diffusion layer thickness. The phase analysis indicates the mixed phases of CrN and Fe_3N, Fe_3N and Fe_4N which has the highest intensity. The results show the glow discharge plasma nitriding in presence of N_2 (80 vol. %) and H_2 (rest) produced higher hardness as well as higher case depth. (author)

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A rare case of primary splenic cyst is shown in a young woman who had a left subcostal abdominal pain. Abdominal echography and CT scan revealed a cyst of the anterior aspect of the spleen. A sorologic test for hidatic disease was negative. On the basis of a presumed diagnostic of nonparasitic cyst, the patient was referred to a laparoscopic decapsulation with excision of the cysts wall not covered by splenic tissue. The patient was discharged 24 hours later. Histological report revealed epidermoid cyst. The laparoscopic approach has being recently considered an effective and less invasive alternative in the treatment of splenic diseases. We demonstrated that it should be considered for the treatment of splenic cysts present in a superficial location, with the advantage of organ preservation. (author)

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ABSTRACT To date the effect of silver-containing wound dressings on biofilms, known to be present in chronic wounds, has not been determined or documented. In this current study, we aimed to determine the antimicrobial effect of a silver-containing dressing on biofilms grown in a chambered slide model. Before the addition of a wound dressing onto a 24-hour biofilm, composed of either Pseudomonas aeruginosa, Enterobacter cloacae, Staphylococcus aureus, or a mixed bacterial community, a fluorescent dye was applied. This enabled the viability of sessile bacteria to be monitored in real-time, using a rapid form of confocal laser scanning microscopy over a contact time period of 48 hours. By analyzing all the three-dimensional data generated from the confocal time-lapse sequences, 90% of all se...

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The conception of a solar receiver intended to equip a tower power-station has to combine multiple requirements: very highly concentrated solar flux, unsteady in time and space; necessity to obtain a high efficiency; respect of the physical limits of the materials and of the fluid. The description of Themis solar receiver and of its operation is preceded by considerations which have led to the choice of the cavity, of the fluid and of its circulation.

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Finland has some 10 million hectares of peatland, accounting for almost a third of its total area. Macroclimatic conditions have varied in the course of the Holocene growth and development of this peatland, and with them the habitats of the peat-forming plants. Temperatures and moisture conditions have played a significant role in determining the dominant species of mire plants growing there at any particular time, the resulting mire types and the accumulation and deposition of plant remains to form the peat. While in a natural state the mires of Finland have functioned as carbon dioxide sinks throughout the post-glacial period, but the ditching of peatland for forestry and agriculture, amounting to some 5,7 million hectares in Finland, has affected their water balance, especially over the last hundred years, and has thereby altered the quantity and species composition of the mire vegetation. The invasion of trees and woody plants to replace the typical mire plants following ditching ...

Science.gov (United States)

To examine whether the neuroendocrine hormone norepinephrine may influence the production of the Shiga-like toxins (SLTs), several Escherichia coli O157:H7 clinical isolates were grown in the presence or absence of norepinephrine. An in vitro culture system consisting of low (<1500 colony-forming units/ml) initial concentrations of inocula into a serum-based medium was used to more closely approximate in vivo conditions. The growth of all isolates was increased several logs in the presence of norepinephrine, as compared with the growth in controls, during a 24-hour growth period. Controls included additional dextrose as well as the use of the norepinephrine metabolite normetanephrine, which contains one more methyl group than norepinephrine and hence would serve as a better energy source for growth if the effect were solely nutritionally mediated. During the 24 hours of growth, the production of ...

British Library Electronic Table of Contents (United Kingdom)

This work addresses the problem of estimating the direction-of-arrival (DOA) of two sources using an array of sensors. This problem is mostly useful in radar applications, where we have few targets at each range bin. Super-resolution algorithms, such as maximum likelihood (ML) estimation and multiple signal classification (MUSIC), have been applied to this problem, but the former involves high computation efforts, while the later has poor estimation performance for coherent sources. In this work, we propose a DOA estimation network, named RBF-AML, which combines the approximated ML (AML) estimator and a radial basis function (RBF) neural network (NN). In the proposed RBF-AML network, the entire two dimensional DOA space is divided into multiple sectors covered by RBF experts. The AML funct...

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International Nuclear Information System (INIS)

A case study is presented where an integrated, ecologically relevant exposure assessment is presented for a polluted lowland river. Using partial least squares regression of latent structures (PLS), an analysis of the impact of two effluents on physico-chemical water quality measures, macroinvertebrate and diatom communities, and in situ bioassay responses with four different test species are combined into an integrative exposure assessment. Bioassays focussed on growth and condition related endpoints, because they are key functional processes of organisms and populations. Integrating these multiple lines of evidence, we were able to discriminate among the impact of both effluents, link changes in physico-chemical water quality with bioassay endpoints and ecological quality of the ecosystem, and address the importance of integrating all information into one exposure assessment framework. The bioassays under field conditions indicated that most ...

CERN Document Server

A reduction of the mass of the \\eta'(958) meson may indicate the restoration of the UA(1) symmetry in a hot and dense hadronic matter, corresponding to the return of the 9th, "prodigal" Goldstone boson. We report on an analysis of a combined PHENIX and STAR data set on the intercept parameter of the two-pion Bose-Einstein correlation functions, as measuremed in \\sqrt{s_NN} = 200 GeV Au+Au collisions at RHIC. To describe this combined PHENIX and STAR dataset, an in-medium \\eta' mass reduction of at least 200 MeV is needed, at the 99.9 % confidence level in a broad model class of resonance multiplicities. Energy, system size and centrality dependence of the observed effect is also discussed.

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Identifying gear damage categories, especially for early faults and combined faults, is a challenging task in gear fault diagnosis. This paper proposes a new multidimensional hybrid intelligent diagnosis method to identify different categories and levels of gear damage automatically. In this method, Hilbert transform, wavelet packet transform (WPT) and empirical mode decomposition (EMD) are performed on gear vibration signals to extract additional fault characteristic information. Then, multidimensional feature sets including time-domain, frequency-domain and time-frequency-domain features are generated to reveal gear health conditions. Multiple classifiers based on several classification algorithms and input features are combined with genetic algorithm (GA). Because of the use of multidim...

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Biomonitoring requires the application of batteries of different biomarkers, as environmental contaminants induce multiple responses in organisms that are not necessarily correlated. Omic technologies were proposed as an alternative to conventional biomarkers since these techniques quantitatively monitor many biological molecules in a high-throughput manner and thus provide a general appraisal of biological responses altered by exposure to contaminants. As the studies using omic technologies increase, it is becoming clear that any single omic approach may not be sufficient to characterize the complexity of ecosystems. This work aims to provide a preliminary working scheme for the use of combined transcriptomic and proteomic methodologies in environmental biomonitoring. There are difficulti...

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The integration of a gas turbine into a new type of coal-fired combined cycle power plant necessitates a multiplicity of far-reaching changes compared with a normal design. The extremely high pre-heating temperature of the air emanating from the heat exchanger of the fluidized bed for the gas turbine combustion chamber has necessitated extensive development work and associated combustion trials. It was possible for these results to influence the design of the burners whereas the manufacture of other components which was on the critical path was already far advanced.

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The LS electromagnetic band (1-4 GHz) is widely used both in domestic and industrial domains. Several studies suggested that the biological systems would exhibit a specific sensitivity to the 2.45 GHz microwaves (water resonance frequency). Potential human health hazards and especially a disruption of the cholinergic system have been reported, due to exposure to microwaves even at low power density. This work presents a multi-parametric study of freely moving rat where neuro-physiology was investigated during 70 hours using neurochemical (micro-dialysis technique), electrophysiological, behavioral (vigilance stages quantification) and thermo-physiological approaches. The rats were exposed 24 hours to a 2.45 GHz pulsed electromagnetic field at low power density. In this exposure conditions, no significant effect have been reported. (authors)

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This paper reports on pumped storage plants which have become an effective way for some utility companies that derive power from hydroelectric facilities to economically store baseload energy during off-peak hours for use during peak hourly demands. According to the Electric Power Research Institute (EPRI) in Palo Alto, Calif., 36 of these plants provide approximately 20 gigawatts, or about 3 percent of U.S. generating capacity. During peak-demand periods, utilities are often stretched beyond their capacity to provide power and must therefore purchase it from neighboring utilities. Building new baseload power plants, typically nuclear or coal-fired facilities that run 24 hours per day seven days a week, is expensive, about $1500 per kilowatt, according to Robert Schainker, program manager for energy storage at the EPRI. Schainker the that building peaking plants at $400 per kilowatt, which run a few hours a day on gas or oil fuel, is less ...

International Nuclear Information System (INIS)

Platelet deposition on bovine pericardial-tissue mitral-valve prostheses in 11 dogs was observed noninvasively by use of "1"1"1In-labeled platelets and quantified after sacrifice at one (n . 3), 14 (n . 3), and 30 (n . 5) days postimplantation (300-400 microCi of labeled platelets having been injected 24 hours previously). Thrombosis on the sewing ring and pericardial leaflets at one and 14 days and on the leaflets at 30 days was delineated in scintiphotos. In vitro quantification (% injected dose) indicated that the leaflets, sewing ring, and perivalvular tissue retained 0.904% of labeled platelets at one day postimplantation, 0.198% at 14 days, and 0.040% at 30 days. Platelet half-life was reduced to 38 hours at 21 days postimplantation but returned toward the normal (50 hours) with fibrous ingrowth in the sewing ring. Microembolism in lung and kidney, as measured by tissue/blood radioactivity ratio, also was decreased significantly at 30 ...

International Nuclear Information System (INIS)

Thirty-four patients with prostatic carcinoma were studied with quantitative bone scintigraphy and whole-body counting (WBC) 1 and 24 h after injection of "9"9"mTc-MDP before as well as two weeks and two months after orchiectomy. Thirteen of the patients had normal bone scintigrams and WBR at the three different investigations; 21 had skeletal metastases. The latter showed throughout the study higher local gamma camera count rates as well as WBR values than the patiens with normal scintigrams. In these patients a ''flare phenomenon'', with an increase in count rate two weeks after orchiectomy followed by a decrease two months post-operatively, was seen with quantitative bone scintigraphy but not with WBC. However, WBC may be a valuable method indicating the total extent of skeletal metastases in the body, while quantitative bone scintigraphy is more accurate in the interpretation of individual skeletal metastases. (orig.).

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Iofetamine HCI {sup 123}I is the generic name for the hydrochloride salt of N-isopropyl-p-iodoamphetamine labeled with {sup 123}I, commonly called IMP. Iofetamine HCI {sup 123}I is prepared by isotopic exchange with [{sup 123}I]Nal and is formulated in isotonic aqueous NaCl solution containing 1 mCi/ml iofetamine HCI I 123, 0.15 mg/ml iofetamine HCI carrier, and phosphate buffer for pH control. The radiochemical purity is >97%, and the product is stable for more than 24 hours; the commercial product distributed today is prepared with high purity {sup 123}I with >98% radionuclidic purity. Two radioiodinated agents have seen significant clinical application for functional brain imaging: iofetamine HCI (IMP) (1) and N,N,N{prime}-trimethyl-N{prime}-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine HIPDM (2). lofetamine HCI {sup 123}I is commercially available in the United States, Europe, and Japan. Although their primary use is for ...

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Dynamic fracture toughness tests were performed on materials which had been subjected to one of three long-time post weld type stress relief heat treatments: 48 hours at 1000/degree/F (538/degree/C), 24 hours at 1125/degree/F (607/degree/C), and 48 hours at 1125/degree/F (607/degree/C). Linear elastic K/sub Id/ results were obtained at low temperatures while J-integral techniques were utilized to evaluate dynamic fracture toughness over the transition and upper shelf temperature ranges. Tensile, Charpy impact, and drop weight nil-ductility transition tests as well as room temperature, air environment fatigue crack growth rate tests (SA508 Cl 2a only) were also performed. The fracture toughness of both materials exceeded the ASME specified minimum reference toughness K/sub IR/ curve. 17 refs.

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A 1,200 bird solar chicken brooder was indigenously designed and operated by the Indian scientists for the first time in the country as a Project under funding by the Ministry of Non Conventional Energy Sources to the All India Women`s Conference. This multi disciplinary project was taken up on the International Sun Day, May 3, 1993 and completed on May, 1994. Data has been collected for the first nine months of operation. Its successful operation has justified multi disciplinary approach. The solar chicken brooder incorporates modern poultry concepts of breeding under controlled temperatures. In view of the mixed climate of Delhi, provision was made for heating and cooling both to take care of the 24 hour cycle. Comfort conditions have been identified and maintained (as is done in the their genetic characteristics) at different temperatures for a period of 8--10 weeks to grow them to a uniform weight of 2.0 kg. Growing them under controlled ...

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North Dakota Concrete Products Company uses a steam curing process that accelerates the concrete curing so that 28-day strength is obtained within 24 hours. The cost of energy required to accomplish this is significant, amounting to approximately $80,000 in 1980. The present boilers are oil fired. Recently, fuel oil prices have increased substantially. Further, supply shortages in the past have threatened plant production. The purpose of this study was to evaluate the economic feasibility of using deep formation warm water as an alternative energy source. A water-to-water heat pump system to replace the existing boiler system was investigated. TPI, Inc. economic and engineering findings for this particular potential geothermal application are disclosed. The operating cost savings of the geothermal system over the operating costs of the existing oilfired system would be insufficient to provide an acceptable rate of return on the investment at ...

International Nuclear Information System (INIS)

Plasma triglyceride turnover was measured during steady-state conditions in 22 postoperative patients. Nine had received nutritional support with an enteral regimen, seven had received an equivalent regimen as continuous parenteral nutrition, and six received the same parenteral regimen as a cyclical infusion. After 5 days of nutritional support, each patient received an intravenous bolus of tritiated glycerol. Plasma radiolabeled triglyceride content was measured during the subsequent 24 hours. The data were analyzed by means of a simple deterministic model of plasma triglyceride kinetics and compared with the results obtained by stochastic analysis. The rates of hepatic triglyceride secretion obtained by deterministic analysis were higher than those obtained by the stochastic approach. However, the mode of delivery of the nutritional regimen did not affect the rate of hepatic triglyceride secretion regardless of the method of analysis. The ...

International Nuclear Information System (INIS)

We studied the dose-response effects of #gamma#-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of "6"0Co #gamma#-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (E13). We found that 0.5 Gy #gamma#-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females. (author).

International Nuclear Information System (INIS)

Quantitative bone scintigraphy was performed at 4 and 24 h after injection of "9"9"mTc-MDP. The lower thoracic and all the lumbar vertebrae were recorded in 37 patients with prostatic carcinoma before orchiectomy as well as two weeks, two and six months postoperatively. Fourteen patients had normal bone scintigrams. By means of the measured variation in the count rate between normal vertebrae, the criterion for a vertebra to be considered as abnormal was determined using the 4 h-uptake values. For patients with normal scintigrams the count rate at 24 h was below the 4 h level and the mean 24 h/4 h ratio was determined to be 0.85 #+-# 0.09 (1 SD). Normal vertebrae in patients with skeletal metastases had only slightly lower count rate values at 24 h than at 4 h. Abnormal vertebrae showed a higher count rate at 24 h, especially two weeks postoperatively, while a tendency towards lower values than at 4 h was seen after 6 months. If the 24 h/4 h ratio is used as an extra criterion to the ...

International Nuclear Information System (INIS)

... A simple representation of multiple scattering in simulation and reconstruction

Science.gov (United States)

Solid fuels such as coal, wood, and crop straw supply some fraction of household cooking and heating fuel for more than one billion people in China. As these fuels do not generally combust cleanly in household stoves, their use levies large health and environmental burdens, particularly in rural regions. Production of clean-burning fuels from agricultural residue offers one prospect for mitigating health and social burdens imposed by household use of solid fuels. This dissertation explores the question: how might production of clean-burning household fuels from agricultural residues affect human health and social conditions in rural China? I approach this question from three perspectives. First, a technically plausible but currently unproven village-scale energy technology is explored in a scenario bounded by natural resources and substantiated by engineering specifications, estimates of indoor exposures to air pollution, and epidemiological analyses. This analysis asks at the national ...

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In many applications, the experimenter has limited options about what factor combinations can be chosen for a designed study. Consider a screening study for a production process involving five input factors whose levels have been previously established. The goal of the study is to understand the effect of each factor on the response, a variable that is expensive to measure and results in destruction of the part. From an inventory of available parts with known factor values, we wish to identify a best collection of factor combinations with which to estimate the factor effects. Though the observational nature of the study cannot establish a causal relationship involving the response and the factors, the study can increase understanding of the underlying process. The study can also help determine where investment should be made to control input factors during production that will maximally influence the response. Because the factor ...

International Nuclear Information System (INIS)

Since the first round of conceptual fusion reactor designs in 1973 - 1974, there has been considerable progress in design improvement. Two recent tokamak designs of the Wisconsin and Culham groups, with increased plasma beta and wall loading (power density), lead to more compact reactors with easier maintenance. The Reference Theta-Pinch Reactor has undergone considerable upgrading in the design of the first wall insulator and blanket. In addition, a conceptual homopolar energy storage and transfer system has been designed. In the case of the mirror reactor, there are design changes toward improved modular construction and ease of handling, as well as improved direct converters. Conceptual designs of toroidal-multiple-mirror, liner-compression, and reverse-field pinch reactors are also discussed. A design is presented of a toroidal multiple-mirror reactor that combines the advantages of steady-state operation and ...

UK PubMed Central (United Kingdom)

We consider the problem of minimal (multiplicative) complexity of polynomial multiplication and multiplication in finite extensions of fields. For infinite fields minimal complexities are known [Winograd,...Full Text Available

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This paper describes how confidence intervals can be calculated for radiofrequency emitter position estimates based on time-of-arrival and frequency-of-arrival measurements taken at several satellites. These confidence intervals take the form of 50th and 95th percentile circles and ellipses to convey horizontal error and linear intervals to give vertical error. We consider both cases where an assumed altitude is and is not used. Analysis of velocity errors is also considered. We derive confidence intervals for horizontal velocity magnitude and direction including the case where the emitter velocity is assumed to be purely horizontal, i.e., parallel to the ellipsoid. Additionally, we derive an algorithm that we use to combine multiple position fixes to reduce location error. The algorithm uses all available data, after more than one location estimate for an emitter has been made, in a mathematically optimal way.

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Greenhouse-effect induced climate change repercussions will, via the catchment areas of big rivers, eventually arrive in amplified form at the far downstream coastal zones of the world. In the coastal zone these imported problems will add to the locally exerted climate change effects, while the climate change induced sea-level rise will attack the coastal zone from the other side, both by flooding and by saline groundwater intrusion. These multiple problems will hit the coastal zone, which is already under increasing stress. The combined threats require fast and massive support for national Coastal Zone Management capabilities, which could help to limit the damage and to support planning for sustainable development. Recommendations are presented to facilitate implementation of Coastal Zone Management units in all coastal countries by the year 2000.

British Library Electronic Table of Contents (United Kingdom)

The results of following the oxidative degradation of a plastic-bonded explosive (PBX 9501) are reported. Into over 1100 sealed containers were placed samples of PBX 9501 and combinations of its components and aged at relatively low temperatures to induce oxidative degradation of the samples. One of the components of the explosive is a poly(ester urethane) polymer and the oxidative degradation of the samples were following by measuring the molecular weight change of the polymer by gel permeation chromatography (coupled with both differential refractive index and multiangle laser light scattering detectors). Multiple temperatures between 40 and 64 degreeC were used to accelerate the aging of the samples. Interesting induction period behavior, along with both molecular weight increasing (cro...

British Library Electronic Table of Contents (United Kingdom)

Rapid and reliable diagnostic methods are needed to control methicillin-resistant Staphylococcus aureus (MRSA) transmission. We studied the BD GeneOhm? MRSA Assay which is based on one specific amplification product at the junction of the right extremity sequence of the staphylococcal cassette chromosome mec (SCCmec) and the chromosomal sequence of orfX of S. aureus. The test was applied on 95 clinical isolates in Finland: 83% were positive. The isolates giving negative results represented several pulsed-field gel electrophoresis (PFGE) types and harboured SCCmec types IV, V, VI or were new types with different combinations of ccr genes.

British Library Electronic Table of Contents (United Kingdom)

Abstract A 3-month, open-label, single-center study was conducted to determine whether a uniquely formulated and physiologically balanced topical treatment serum containing multiple growth factors, cytokines, peptides, antioxidants and depigmenting agents could improve the visible signs of facial photodamage. Thirty-seven females, aged 32-55 years, with mild to severe, fine and coarse peri-ocular wrinkles were enrolled and completed the study. Subjects applied the treatment serum to the face twice daily for 3 months in conjunction with a basic skincare regimen. Clinical evaluations of photodamage were performed at baseline and months 1, 2 and 3. Cutometer measurements and subject self-assessment questionnaires were also conducted during the study. Clinical evaluations showed statistically ...

International Nuclear Information System (INIS)

Apparatus for solid-phase antibody separation techniques used in radioimmunoassays is described in this invention. It consists of a rectangular prism tray with multiple wells protruding into its interior from one side. Near the base of the tray is an orifice used for creating evacuated condition within the structure. At the base of each well there is an orifice of such size and shape as to retain an aqueous liquid under given pressure conditions but permit the evacuation of this liquid at reduced pressure. The outlet of these orifices is in the shape of an inverted conical frustrum. Each of the wells contains an antibody coated disc of porous cellulose paper surrounded by a plastic support. The porous nature of the cellulose paper ensures contact between the antibody coating and the antigen. The use of antibody coated porous cellulose paper in combination with the vacuum operated apparatus simplifies the manipulative steps whilst still ...

KoreaScience (Korea)

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International Nuclear Information System (INIS)

... fftf reactor mockup multiplication factors reactivity worths reactor cores reactor

International Nuclear Information System (INIS)

Current regulations guiding technical aspects of natural resource damage assessments combine source, exposure pathway, resource injury, and monetary damage components. In order to associate any observed injury to the uncontrolled release of chemicals (e.g. oil spills, contaminated sediments, in-place toxics, etc.), it is important to link the chemical ''release'' to the injured resource. In complex environmental settings where multiple sources of similar chemicals are combined, multicomponent chemical methods must be used to link the release to the environmental distribution of chemicals. Three examples of the utility of multicomponent organic chemical analyses linked to comprehensive and representative sampling strategies will be discussed--the Shell Martinez Refinery oil spill, the Exxon Valdez oil spill, and a contaminated sediment assessment. These NRDA-based source identifications are based on use of polycyclic ...

Energy Technology Data Exchange (ETDEWEB)

The staging of patients with multiple myeloma demands sensitive imaging methods for the assessment of the skeletal system. MRI allows for direct visualization of the bone marrow which exhibits five different infiltration patterns in multiple myeloma: 1. normal appearance of the bone marrow, 2. focal involvement, 3. homogeneous diffuse infiltration, 4. combined diffuse and focal infiltration, 5. ''salt and pepper'' pattern with inhomogeneous bone marrow signals due to multiple fat islands. The combination of T1w-SE and STIR sequences is best suited for detecting all infiltration patterns and for the differential diagnoses e. g. hemangiomas. With parallel imaging in MRI, acquisition times can be markedly reduced and whole-body screening of the bone marrow can be achieved within 30 min. MRI is superior to radiography for the detection of focal as ...

Energy Technology Data Exchange (ETDEWEB)

The translocation of particles from the alveolar compartment to the pleural space and tracheobronchial lymph nodes was investigated in rats over a 30 day period following the intrapulmonary instillation of 4 x 10/sup 8/ polystyrene microspheres (1.9 ..mu..m dia.). In initial studies, approx. =10/sup 4/ particles were found in the pleural space compartment on Days 1, 14 and 30 after particle deposition, and most of these were cell-associated. Subsequent pleural space studies indicated, however, that the particles found in this compartment were, at least in part, due to the pleural lavage technique, and, unlike observations reported for some fibers, the translocation of the particles used in our study to the pleural space does not represent an important lung clearance pathway. In regard to particle clearance to the tracheobronchial lymph nodes, the accumulation of particles, most of which were extracellular, kinetically was biphasic with the most rapid phase occurring within the first ...

International Nuclear Information System (INIS)

The effect of in vitro and in vivo administration of ethanol on the binding of "3"5S-t-butyl-bicyclophosphorothionate ("3"5S-TBPS) to cortical brain membranes of C57B1 mice was investigated using KCl (100 mM) containing assay media. The in vitro addition of ethanol produced a dose-dependent inhibition of basal "3"5S-TBPS binding. In the presence of chloride ions, GABA and pentobarbital had a biphasic action (stimulation followed by inhibition) on "3"5S-TBPS binding, whereas diazepam only stimulated the binding. Ethanol reduced the stimulatory effects of GABA and pentobarbital in a dose-dependent manner, but had no effect on the enhancement of "3"5S-TBPS binding produced by diazepam. "3"5S-TBPS binding to cortical brain membranes was inhibited by the putative Cl"- channel blocking agent DIDS. This inhibitory action of DIDS was significantly, and dose-dependently reduced by ethanol (#<=# 100 mM ethanol). Chronic ethanol ingestion in vivo, which produced tolerance to and physical ...

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Activation dose rates have been computed for the Poloidal Divertor Experiment Tokamak at the Princeton Plasma Physics Laboratory. Dose rates were computed in one-dimensional (cylindrical) geometry using the ANISN S/sub n/ transport theory code and the DKR radioactivity code. The EPR (DLC37F) 121-group coupled neutron-gamma cross section library was used with ANISN. For DKR, the 46-group neutron library of DCDLIB was employed. Dose rates were calculated for 1 minute, 1 hour, 6 hours, 24 hours, 1 week, and 1 month following a single pulse yielding 10/sup 15/ neutrons and for 2 hypothetical pulsing sequences. First, it was assumed that 10 pulses were conducted each day (1 hour apart) for 5 days. Second, it was assumed that 100 pulses were conducted each day (6 minutes apart) for 5 days. It was found that /sup 56/Mn and /sup 64/Cu are the main contributors to the dose at short time periods after shutdown, while, for long time periods, /sup 58/Co ...

Energy Technology Data Exchange (ETDEWEB)

Pulsatile hormone secretion is observed in almost every hormonal system. The frequency of episodic hormone release ranges from approximately 10 to 100 pulses in 24 hours. This temporal mode of secretion is an important feature of intercellular information transfer in addition to a dose-response dependent regulation. It has been demonstrated in a number of experiments that changes in the temporal pattern of pulsatile hormone secretion specifically regulate cellular and organ function and structure. Recent evidence links osteoporosis, a disease characterized by loss of bone mass and structure, to changes in the dynamics of pulsatile parathyroid hormone (PTH) secretion. In our study we applied nonlinear and linear time series prediction to characterize the secretory dynamics of PTH in both healthy human subjects and patients with osteoporosis. Osteoporotic patients appear to lack periods of high predictability found in normal humans. In contrast ...

Science.gov (United States)

Sixty-Hz magnetic field exposures were measured for 45 adult residents of Maine. Thirty of the subjects resided near rights-of-way (ROWs) with either 345- and 115-kV transmission lines, or ROWs with only 115-kV transmission lines; fifteen resided far from any transmission lines. Personal exposure data for a single 24-hour period was acquired with the EMDEX. The EMDEX's event-marker button was used to partition exposures into Home and Away components. Also, three area measurements were taken for each subject during the personal exposure measurement period: (1) 24-hr fixed-site bedroom measurement with a second EMDEX; (2) Spot measurements in at least three rooms of every residence; and (3) Spot measurements outside each residence. Residence near transmission lines highly loaded during the measurement period was associated with increased Home and Total exposure relative to a far-away population. Average exposure level while away from ...

Energy Technology Data Exchange (ETDEWEB)

We studied the interaction of Pu(VI) with Pseudomonas stutzeri ATCC 17588 and Bacillus sphaericus ATCC 14577, representatives of the main aerobic groups of soil bacteria present in the upper soil layers. The accumulation studies have shown that these soil bacteria accumulate high amounts of Pu(VI). The sorption efficiency toward Pu(VI) decreased with increasing biomass concentration due to increased agglomeration of the bacteria resulting in a decreased total surface area and number of available complexing groups. Spores of Bacillus sphaericus showed a higher biosorption than the vegetative cells at low biomass concentration which decreased significantly with increasing biomass concentration. At higher biomass concentrations (> 0.7 g/L), the vegetative cells of both strains and the spores of B. sphaericus showed comparable sorption efficiencies. Investigations on the pH dependency of the biosorption and extraction studies with 0.01 M EDTA solution have shown that the biosorption ...

Energy Technology Data Exchange (ETDEWEB)

Because of heightened media coverage, a 24-hour news cycle and the potential miscommunication of health messages across all levels of government during the onset of the H1N1 influenza outbreak in spring 2009, the Illinois Department of Public Health (IDPH) decided to evaluate its H1N1 influenza A communications system. IDPH wanted to confirm its disease information and instructions were helping stakeholders prepare for and respond to a novel influenza outbreak. In addition, the time commitment involved in preparing, issuing, monitoring, updating, and responding to H1N1 federal guidelines/updates and media stories became a heavy burden for IDPH staff. The process and results of the H1N1 messaging survey represent a best practice that other health departments and emergency management agencies can replicate to improve coordination efforts with stakeholder groups during both emergency preparedness and response phases. Importantly, the H1N1 survey ...

International Nuclear Information System (INIS)

Lysozyme, ethylenediaminetetracetic acid, chlorine, x-irradiation and microwaves were used in experimental attempts to eliminate Salmonella senftenberg 775W or Salmonella typhimurium from turkey drumsticks and whole carcasses. Turkey drumsticks or whole carcasses were artificially contaminated with S. senfenberg 775W or S. typhimurium in concentrations ranging between 5 x 10"5 to 8 x 10"5 viable cells per ml. of contaminating fluid. After each treatment, samples were cultured, plated, and tested according to standard methods to determine the susceptibility of Salmonella organisms to the particular treatment. A 0.1 percent solution of lysozyme eliminated the S. senftenberg 775W at 22"0C within three hours. A 0.5 percent solution of ethylenediaminetetracetic acid failed to destroy the test organism under the same conditions. Eighty thousand rads of X-ray eliminated the test organism on turkey drumsticks but failed to remove it from whole turkey carcasses. Microwaves eliminated the S. ...

Energy Technology Data Exchange (ETDEWEB)

The energetic characteristics of 6 types of poplar clones cultivated for different pedoclimatic conditions in Romania were determined. Four clones were developed in Italy and 2 in Romania. Five experimental cultures were used to analyze the plant survival rate and biomass production rate. After 2 years of study, the Italian clones were found to have very good adaptability to the pedoclimatic conditions in Romania in comparison with local clones. The Italian clones Monviso and AF-6 registered the most substantial growths and the highest resistance to disease. Bioethanol was synthesized by acidic hydrolysis of the cellulose using 2 approaches. In the first approach the lignocellulosic raw material was hydrolyzed with diluted sulfuric acid at 50 degrees C for 24 hours. After filtration, the solid residue was treated with 30 per cent H{sub 2}SO{sub 4} at 100 degrees C for 6 hours. The resulting solutions were neutralized with Ca(OH){sub 2} ...

Energy Technology Data Exchange (ETDEWEB)

The three main objectives of this study were: (1) to determine if depletion of proteoglycans from the cartilage matrix that occurs during osteoarthritis causes a measurable increase of cartilage proteoglycan components in the synovial fluid and sera, (2) to observe what effect intracellular cAMP has on the expression of matrix components by chondrocytes, and (3) to determine if freshly isolated chondrocytes contain detectable levels of mRNA for fibronectin. Canine serum keratan sulfate and hyaluronate were measured to determine if there was an elevation of these serum glycosaminoglycans in a canine model of osteoarthritis. A single intra-articular injection of chymopapain into a shoulder joint increased serum keratan sulfate 10 fold and hyaluronate less than 2 fold in 24 hours. Keratan sulfate concentrations in synovial fluids of dogs about one year old were unrelated to the presence of spontaneous cartilage degeneration in the joints. High ...

International Nuclear Information System (INIS)

Nodular hepatic involvement of multiple myeloma is very rare. We report here on a case of nodular hepatic involvement of multiple myeloma that mimicked intrahepatic cholangiocarcinoma. In patients with multiple myeloma, hepatic involvement of the multiple myeloma might be included in the differential diagnosis of hepatic mass.

UK PubMed Central (United Kingdom)

BackgroundIndividuals living in malaria endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator of immune status. However,...Full Text Available

UK PubMed Central (United Kingdom)

More than 30 years of experience in developing a computer-based patient record system, The Medical Record (TMR), in multiple settings, in multiple specialty groups, and at multiple sites has taught...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A case is reported of a 23-year old male with multiple glomus tumours that showed marked involution after he had electron beam therapy. (author).

UK PubMed Central (United Kingdom)

SUMMARYIncreasingly multiple outcomes are collected in order to characterize treatment effectiveness or to evaluate the impact of large policy initiatives. Often the multiple...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A proton exchange membrane fuel cell (PEMFC) must maintain a balance between the hydration level required for efficient proton transfer and excess liquid water that can impede the flow of gases to the electrodes where the reactions take place. Therefore, it is critically important to understand the two-phase flow of liquid water combined with either the hydrogen (anode) or air (cathode) streams. In this paper, we describe the design of an in situ test apparatus that enables investigation of two-phase channel flow within PEMFCs, including the flow of water from the porous gas diffusion layer (GDL) into the channel gas flows; the flow of water within the bipolar plate channels themselves; and the dynamics of flow through multiple channels connected to common manifolds which maintain a uniform pressure differential across all possible flow paths. These two-phase flow effects have been studied at relatively low operating temperatures under ...

British Library Electronic Table of Contents (United Kingdom)

The structure of the O-antigen polysaccharide (PS) from Escherichia coli O177 has been determined. Component analysis together with 1H and 13C NMR spectroscopy experiments was used to determine the structure. Inter-residue correlations were determined by 1H,13C-heteronuclear multiple-bond correlation and 1H,1H-NOESY experiments. PS is composed of tetrasaccharide repeating units with the following structure: 2)-a-l-Rhap-(13)-a-l-FucpNAc-(13)-a-l-FucpNAc-(13)-b-d-GlcpNAc-(1 An a-l-Rhap residue is suggested to be present at the terminal part of the polysaccharide, which on average is composed of 20 repeating units, since the 1H and 13C chemical shifts of an a-linked rhamnopyranosyl group could be assigned by a combination of 2D NMR spectra. Consequently, the biological repeating unit has a 3-...

CERN Document Server

Being able to distinguish light-quark jets from gluon jets on an event-by-event basis could significantly enhance the reach for many new physics searches at the Large Hadron Collider. Through an exhaustive search of existing and novel jet substructure observables, we find that a multivariate approach can filter out over 95% of the gluon jets while keeping more than half of the light-quark jets. Moreover, a combination of two simple variables, the charge track multiplicity and the pT-weighted linear radial moment (girth), can achieve similar results. While this pair appears very promising, our study is only Monte Carlo based, and other discriminants may work better with real data in a realistic experimental environment. To that end, we explore many other observables constructed using different jet sizes and parameters, and highlight those that deserve further theoretical and experimental scrutiny. Additional information, including distributions ...

International Nuclear Information System (INIS)

Employing a recently developed Monte-Carlo model, we study the fission of 240Pu induced by neutrons with energies from thermal to just below the threshold for second chance fission. Current measurements of the mean number of prompt neutrons emitted in fission, together with less accurate measurements of the neutron energy spectra, place remarkably fine constraints on predictions of microscopic calculations. In particular, the total excitation energy of the nascent fragments must be specified to within 1MeV to avoid disagreement with measurements of the mean neutron multiplicity. The combination of the Monte-Carlo fission model with a statistical likelihood analysis also presents a powerful tool for the evaluation of fission neutron data. Of particular importance is the fission spectrum, which plays a key role in determining reactor criticality. We show that our approach can be used to develop an estimate of the fission spectrum with ...

Science.gov (United States)

This paper proposes a new pattern recognition system employing optical joint transform correlation (JTC) technique which offers a great number of advantages over similar digital techniques, including very fast operation, simple architecture and capability of updating the reference image in real time. The proposed JTC technique incorporates a synthetic discriminant function (SDF) of the target image estimated from different training images to make the pattern recognition performance invariant to noise and distortion. It then involves four different phase-shifted versions of the same target SDF reference image, which are individually joint transform correlated with the given input scene. When the correlation signals are combined, it produces a single cross-correlation peak corresponding to each potential target present in the given input scene. The proposed technique also includes a fringe-adjusted filter to generate a delta-like correlation peak with high ...

CERN Document Server

To understand evolutionary and environmental effects during the formation of high-mass stars, we observed three regions of massive star formation at different evolutionary stages that reside in the same natal molecular cloud. Methods. The three regions S255IR, S255N and S255S were observed at 1.3 mm with the Submillimeter Array (SMA) and followup short spacing information was obtained with the IRAM 30m telescope. Near infrared (NIR) H + K-band spectra and continuum observations were taken for S255IR with VLT-SINFONI to study the different stellar populations in this region. The combination of millimeter (mm) and near infrared data allow us to characterize different stellar populations within the young forming cluster in detail. While we find multiple mm continuum sources toward all regions, their outflow, disk and chemical properties vary considerably. The most evolved source S255IR exhibits a collimated bipolar outflow visible in CO and H2 ...

Energy Technology Data Exchange (ETDEWEB)

This paper presents a new technique--Integrated Bayesian Uncertainty Estimator (IBUNE) to account for the major uncertainties of hydrologic rainfall-runoff predictions explicitly. The uncertainties from the input (forcing) data--mainly the precipitation observations and from the model parameters are reduced through a Monte Carlo Markov Chain (MCMC) scheme named Shuffled Complex Evolution Metropolis (SCEM) algorithm which has been extended to include a precipitation error model. Afterwards, the Bayesian Model Averaging (BMA) scheme is employed to further improve the prediction skill and uncertainty estimation using multiple model output. A series of case studies using three rainfall-runoff models to predict the streamflow in the Leaf River basin, Mississippi are used to examine the necessity and usefulness of this technique. The results suggests that ignoring either input forcings error or model structural uncertainty will lead to unrealistic model simulations and ...

Science.gov (United States)

The AFGD process as demonstrated by Pure Air at the Bailly Station offers a reliable and cost-effective means of achieving a high degree of SO{sub 2} emissions reduction when burning high-sulfur coals. Many innovative features have been successfully incorporated in this process, and it is ready for widespread commercial use. The system uses a single-loop cocurrent scrubbing process with in-situ oxidation to produce wallboard-grade gypsum instead of wet sludge. A novel wastewater evaporation system minimizes effluents. The advanced scrubbing process uses a common absorber to serve multiple boilers, thereby saving on capital through economies of scale. Major results of the project are: (1) SO{sub 2} removal of over 94 percent was achieved over the three-year demonstration period, with a system availability exceeding 99.5 percent; (2) a large, single absorber handled the combined flue gas of boilers generating 528 MWe of power, and no spares were ...

Science.gov (United States)

In the current wind turbine generation system, there are substantial problems such as the maximum power of the wind turbine cannot be obtained under the fluctuating wind speed, high in cost and low in annual net electricity production (due to mismatch between a generator and a wind turbine). A new wind turbine generator optimized for the wind turbine output is presented in order to solve such problems. This wind turbine generator consists of a permanent magnet generator, a reactor and a rectifier, and uses neither a control circuit which requires standby electricity nor a PWM converter having a switching element. By selecting most appropriate combination of the permanent magnet generator having multiple windings and the reactor connected in series with each winding, the maximum output of the wind turbine can be obtained without using a control circuit. The new wind turbine generator was directly coupled with the straight wing non-articulated ...

Energy Technology Data Exchange (ETDEWEB)

Resistance to thyroid hormone (RTH) is an autosomal dominant disease caused by mutations in the human thyroid receptor beta gene on chromosome 3. Individuals with RTH have an increased incidence of attention deficit hyperactivity disorder (ADHD). The purpose of this study was to search for developmental brain malformations associated with RTH. Forty-three subjects (20 affected males [AM], 23 affected females [AF]) with resistance to thyroid hormone and 32 unaffected first degree relatives (18 unaffected males [UM], 14 unaffected females [UF]) underwent MRI brain scans with a volumetric acquisition that provided 90 contiguous 2 mm thick sagittal images. Films of six contiguous images beginning at a standard sagittal position lateral to the insula were analyzed by an investigator who was blind with respect to subject characteristics. The presence of extra or missing gyri in the parietal bank of the Sylvian fissure (multimodal association cortex) and multiple Heschl`s ...

International Nuclear Information System (INIS)

Purpose: To develop an accurate, fast, and robust algorithm for registering portal and computed tomographic (CT) images for radiotherapy using a combination of sparse and dense field data that complement each other. Methods and Materials: Gradient Feature Weighted Minimax (GFW Minimax) method was developed to register multiple portal images to three-dimensional CT images. Its performance was compared with that of three others: Minimax, Mutual Information, and Gilhuijs' method. Phantom and prostate cancer patient images were used. Effects of registration errors on tumor control probability (TCP) and normal tissue complication probability (NTCP) were investigated as a relative measure. Results: Registration of four portals to CTs resulted in 30% lower error when compared with registration with two portals. Computation time increased by nearly 50%. GFW Minimax performed the best, followed by Gilhuijs' method, the Minimax method, and Mutual ...

UK PubMed Central (United Kingdom)

ObjectiveCOMBINE is the largest study of pharmacotherapy for alcoholism in the United States to date, designed to answer questions about the benefits of combining...Full Text Available

J-STORE (Japan)

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KoreaScience (Korea)

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CERN Document Server

It is well known that the zeros of orthogonal polynomials interlace. In this paper we study the case of multiple orthogonal polynomials. We recall known results and some recursion relations for multiple orthogonal polynomials. Our main result gives a sufficient condition, based on the coefficients in the recurrence relations, for the interlacing of the zeros of neighboring multiple orthogonal polynomials. We give several examples illustrating our result.

KoreaScience (Korea)

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International Nuclear Information System (INIS)

Short communication.

Energy Technology Data Exchange (ETDEWEB)

An efficient method of hydrogen storage in nano-porous carbons is its reversible sorption by electrochemical decomposition of a KOH water solution according to the following equation: C + xH{sub 2}O + xe{sup -} {yields} (CH{sub x}) + xOH{sup -} where (CH{sub x}) stands for the hydrogen inserted into the nano-porous carbon during charging and oxidized during discharging. Although various carbon materials have been investigated as hydrogen adsorbents, the information about the storage mechanism as well as the nature of the hydrogen/carbon interaction is still not sufficient. In order to extend the understanding of the process, carbon samples charged electrochemically were investigated by temperature programmed desorption (TPD). The nature of the hydrogen/carbon interaction was studied by electrochemical analysis at different temperatures. The TPD experiments consist of heating the samples from room temperature to 950 C and of quantitative analysis by On-line mass spectrometry, the ...

Energy Technology Data Exchange (ETDEWEB)

Full text: In 1995, we demonstrated the use of pretargetting three steps method and biotinylated tetracycline using radiolabelled {sup 99m}Tc-DTPA-biocytinamide for the detection of tumour cells in (C57B1/6 x BALB/C) F1 mice with E-3 thymoma. The three steps were (1) IP injection of biotinylated-tetracycline conjugate (1:1) ratio, (2) 96 hours later Avidin/Streptavidin was injected, and (3) 24 hours after (2), {sup 99m}Tc-biocytinamide -cDTPA was injected. Mice were sacrificed 16/24 h after (3) by cervical dislocation. Biodistribution of radioactivity tumour to blood, liver, bone were T:B1= 15.0, T:Li= 5.08, T:Bo=15.0. The percentage of injected dose per g was T= 3.15% and B1= 0.21%. To prolong circulation of Avidin and therefore its uptake into tumour, Avidin was covalently bound to polyethylene-glycol (PEG20 KD) at the molar ratio of PEG:Avidin 100:1 and 400:1. The pegulated Avidin was then cleared from the circulation using ...

Energy Technology Data Exchange (ETDEWEB)

Purpose : To evaluate whether the early pulmonary irradiation can prevent or decrease the pulmonary damage and contribute to improve ultimate survival in paraquat lung. Materials and Methods : From Jun. 1987 to Aug. 1993, thirty patients with paraquat poisoning were evaluated. Fourteen of these patients were received pulmonary irradiation(RT). All of the patients ere managed with aggressive supportive treatment such as gastric lavage, forced diuresis, antioxidant agents and antifibrosis agents. Ingested amounts of paraquat were estimated into three groups(A: minimal < about 5cc, B: mouthful 5-50 cc, C: Large > 50cc). Pulmonary irradiation was started within 24 hours after admission(from day 1 to day 11 after ingestion of paraquat). Both whole lungs were irradiated with AP/PA parallel opposing fields using C0-60 teletherapy machine. A total of 10Gy(2Gy/fr. X 5 days)was delivered without correction of lung density. Results : In ...

International Nuclear Information System (INIS)

Off-grid power generation is meant to supply remote or rural area, where grid connection is almost impossible in terms of cost and geography, such as island, aborigine's villages, and areas where nature preservation is concern. Harnessing an abundance renewable energy sources using versatile hybrid power systems can offer the best, least-cost alternative solution for extending modern energy services to remote and isolated communities. The conventional method for off-grid power generation is using diesel generator with a renewable energy (RE) technology utilizing solar photovoltaic, wind, biomass, biogas and/or mini/micro hydro. A hybrid technology is a combination of multiple source of energy; such as RE and diesel generator and may also include energy storage such as battery. In our design, the concept of solar hybrid system is a combination of solar with diesel genset and battery as an energy storage. The main objective ...

Energy Technology Data Exchange (ETDEWEB)

The Physikalisch-Technische Bundesanstalt (PTB), Germany's national metrology institute, developed an alignment strategy to specify elemental depth profiling in vertical sidewall layers on structured wafers. For this purpose, PTB's irradiation chamber for 200 mm and 300 mm silicon wafers was used to combine total-reflection X-ray fluorescence (TXRF) and grazing incidence XRF (GIXRF) techniques by employing monochromatized undulator radiation of the BESSY II electron storage ring. 3-D test structures were fabricated to develop an optimal alignment strategy allowing for depth profiling in such nanolayers. The test structures consisted of silicon bars with widths/spacings either in the {mu}m or in the nm range. In order to be able to differentiate the sidewalls more easily from the remainder of the structures, they were provided with an additional silicon nitride layer. Four structure types of different bar width and density parameters on two 200 mm ...

UK PubMed Central (United Kingdom)

BackgroundIn prognostic studies model instability and missing data can be troubling factors. Proposed methods for handling these situations are bootstrapping (B) and Multiple imputation...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSymptomatic heterotopic ossification (HO) in multiple trauma patients may lead to follow up surgery, furthermore the long-term outcome can be restricted. Knowledge of the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The possibility of studying the adsorption of acetic acid vapour on coal by the method of multiple attenuated total internal reflection by two proposed procedures has been shown.

UK PubMed Central (United Kingdom)

The pharmacokinetic parameters of amikacin and ceftazidime were assessed in four patients undergoing hemofiltration for septic shock. The parameters were assessed during hemofiltration and in the interim...Full Text Available

UK PubMed Central (United Kingdom)

Study objectives:To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors.Design:Prospective,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The Feynmann and other fluctuation techniques have been shown to be useful for determining the multiplication of subcritical systems. The moments of the counting distribution from neutron detectors is analyzed to yield the multiplication value. We present the methodology and some selected applications and results and comparisons with Monte Carlo calculations.

UK PubMed Central (United Kingdom)

BackgroundThere is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS)....Full Text Available

UK PubMed Central (United Kingdom)

In multiple sclerosis (MS), oligodendrocyte and myelin destruction lead to demyelination with subsequent axonal loss. Experimental demyelination in rodents has highlighted the activation of the subventricular...Full Text Available

UK PubMed Central (United Kingdom)

Objectives:There is no study about correlation between vitamin D serum level and multiple sclerosis (MS) in Iran. So in this survey, we investigated the serum level of 25-hydroxy...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

The cross sections for proton-proton elastic scattering at Fermilab and ISR energies are investigated in the framework of the multiple constituent scattering formalism, including the contributions of the inelastic intermediate states. We find that the higher-order multiple scattering amplitudes are strongly suppressed due to the presence of the inelastic intermediate states. The calculated cross sections reproduce the high energy experimental data fairly well. (author).

Energy Technology Data Exchange (ETDEWEB)

No abstract available.

Energy Technology Data Exchange (ETDEWEB)

An efficient method of hydrogen storage in nano-porous carbons is its reversible sorption by electrochemical decomposition of a KOH water solution [1-3] according to the following equation: C + xH{sub 2}O + xe{sup -} {yields} (CH{sub x}) + xOH{sup -} where (CH{sub x}) stands for the hydrogen inserted into the nano-porous carbon during charging and oxidized during discharging. Although various carbon materials have been investigated as hydrogen adsorbents, the information about the storage mechanism as well as the nature of the hydrogen/carbon interaction is still not sufficient. In order to extend the understanding of the process, carbon samples charged electrochemically were investigated by temperature programmed desorpt(TPD). The nature of the hydrogen/carbon interaction was studied by electrochemical analysis at different temperatures. The TPD experiments consist of heating the samples from room temperature to 950 C and of quantitative analysis by on-line mass spectrometry, the ...

Energy Technology Data Exchange (ETDEWEB)

In the United States, estimates show that more than 30,000 hazardous waste disposal sites exist, not including military installations, U.S. Department of Energy nuclear facilities, and hundreds and thousands of underground fuel storage tanks; these sites undoubtedly have their own respective hazardous waste chemical problems. When so many sites contain hazardous chemicals, how does one study the health effects of the chemicals at these sites? There could be many different answers, but none would be perfect. For an area as complex and difficult as the study of chemical mixtures associated with hazardous waste disposal sites, there are no perfect approaches and protocols. Human exposure to chemicals, be it environmental or occupational, is rarely, if ever, limited to a single chemical. Therefore, it is essential that we consider multiple chemical effects and interactions in our risk assessment process. Systematic toxicity testing of chemical mixtures in the ...

Energy Technology Data Exchange (ETDEWEB)

The overall goal of the proposed project is to explore the use of partitioning tracers to characterize dense nonaqueous phase liquids (DNAPLs) in aquifer systems. Bulk-phase partitioning tracers will be investigated to detect and determine DNAPL saturation, while interface partitioning tracers will be investigated to measure the area of the DNAPL-water interface. The specific objectives that will be addressed to accomplish this goal are: (1) Investigate the use of partitioning tracers to detect and determine both the saturation and interfacial area of DNAPLs in saturated porous media. (2) Investigate the effect of rate-limited mass transfer on the transport behavior of partitioning tracers. (3) Investigate the effect of porous-media heterogeneity on the transport behavior of partitioning tracers. (4) Develop and evaluate mathematical models capable of simulating the transport of partitioning tracers in complex systems. This proposal outlines an integrated approach for the development ...

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Multiple linear regression, principal component analysis, partial least squares, polynomial regression and artificial neural networks are popular techniques for process modeling. An industrial case study illustrates some of these technologies, with an emphasis on artificial neural networks. Experience with this and other projects indicates that while neural network models, combined with partial least squares when necessary, are an excellent tool for modeling, linear techniques may also be appropriate in some cases. Regardless of the specific method used, software analyzers are an attractive lower-cost alterative to hardware options in some monitoring applications. From a fundamental point of view, the result of chemical analysis can be considered as the dependent variable(s) of a process system having a number of independent variables. The independent variables are the causes and the chemical analysis is the effect. If the cause-and-effect ...

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This paper describes a gas transmission pipeline company with dissimilar local control and Supervisory Control and Data Acquisition (SCADA) systems that had formed over time, and the solution that was put into place to consolidate those systems. Great Lakes Gas Transmission Company (GLGT) had historically operated the pipeline from four geographically different locations with a combination of various local man-machine interface (MMI) control systems and an aging SCADA system. As new control systems were installed at compressor and meter stations, local and corporate data acquisition needs changed. It became apparent that the existing SCADA system which telemetered a minimal set of control data could no longer support growth requirements. The decision was made to replace the old SCADA system with a new open state-of-the-art architecture. As a result of competitive bidding, the Valmet OASyS (Open Architecture SyStem) was selected and installed at ...

Energy Technology Data Exchange (ETDEWEB)

We have examined the theory of NMR multiple echoes developed for solid {sup 3}He to determine whether multiple echoes could be observed in solid hydrogen. We were particularly interested in the possibility of testing for low frequency quantum tunneling motions in solid hydrogen by the observation of multiple echoes. We find that for easily accessible nuclear spin polarizations, P > 12%, multiple echoes would be observed for HD impurities in solid parahydrogen if motional narrowing is effective in increasing the HD nuclear spin-spin relaxation time T{sub 2} to the order of 1 msec. These values for T{sub 2}, which have been observed for HD impurity concentrations of the order of 1%, are larger than the calculated rigid lattice values and can be attributed to quantum tunneling at frequencies of the order of 1kHz.

International Nuclear Information System (INIS)

Full text: As you know, thin films which generate anomalous big photovoltage (APhV) , as film photo resistive structures made of the combinations of A_2B_6 respond to X-ray and #gamma#- radiations. In this work the influence of X-ray and #gamma#-radiations on the quantity of APhV in the system APhV-film-photoresistor was investigated. Earlier polycrystal films with anomalous photo voltage properties were received only on the clean and flat surface with high isolation property (R>10"1"4 #OMEGA#). We worked out the technology of receiving APhV films CdTe on the surface of the photosensitive film CdS. The main condition under which this effect may be observed is that the lining must be slant concerning to the direction of the motion of evaporated substance's molecular bunch during the growing of the film, i.e. received film must have a dendritic structure. That is why photosensitive film CdS was received with thermo vacuum slanting pulverization (#alpha#=30-60 ...

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Simple recursion formulas are derived for the multiplicities of the dominant weight vectors appearing in a class of irreducible highest weight representations of the indecomposable affine Kac-Moody algebras. This class is characterized by the appearance of exactly two distinct infinite sequences of dominant weight vectors. The general procedure used for the enumeration of these representations and for the derivation of the corresponding multiplicity formulas is that presented by Capps for the analysis of those irreducible representations containing exactly one such infinite sequence. This procedure includes the classification of representations in terms of congruence and the identification of Weyl orbits by the norm of the dominant weight. Some of the results presented have application to physical theories such as string field theories.

Energy Technology Data Exchange (ETDEWEB)

A multiple sampling dE/dx counter using a multiwire proportional chamber equipped with catbode pads was constructed for the multiple detection of dE/dx values along a particle trajectory. For low-energy particles this counter was proved to be useful as a Bragg-curve detector. At relativistic energies around E=14.6 GeV/nucleon good particle identification was obtained by cathode pad signals as well as anode signals for the range of projectile fragments from Z=1 (minimum ionization) up to a beam charge of Z=14. (orig.).

Science.gov (United States)

integrates multiple fisheries information systems to obtain a view of U.S. freshwater fish distribution. Information about NFDI National Framework for Early Detection, Rapid...

UK PubMed Central (United Kingdom)

Autophagy is an evolutionarily conserved, catabolic process that involves the entrapment of cytoplasmic components within characteristic vesicles for their delivery to and degradation within lysosomes....Full Text Available

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BackgroundThe availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an...Full Text Available

International Nuclear Information System (INIS)

French (1979). France Dolique, JM Grenoble-1 Univ., 38 (France) Grenoble,

UK PubMed Central (United Kingdom)

A unique case of pachydermoperiostosis, multiple epiphyseal dysplasia, and secondary osteoarthritis is described. An additional interesting feature was the presence of acroosteolysis of the distal phalanges...Full Text Available

UK PubMed Central (United Kingdom)

Schizophrenia is a heterogeneous psychiatric disorder in which multiple neurotransmitter systems have been implicated. Increased and decreased dopamine transmission in the subcortical meso-limbic and...Full Text Available

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... less humans have to do to operate a robot. ... Robots can help human operators with the increase ... important mission outlined by the UUV master plan. ...

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... 146 27 1 Aug 83, outlet works excavation. Sewer pipe installation. ... No. 157. Outlet works excavation. Sewer pipe installation. ...

International Nuclear Information System (INIS)

Multiple Reggeon exchange supplies subleading logarithms that may be used to restore unitarity to the Low-Nussinov Pomeron, provided it can be proven that the sum of Feynman diagrams to all orders gives rise to such multiple Regge exchanges. This question cannot be easily tackled in the usual way except for very low-order diagrams, on account of delicate cancellations present in the sum which necessitate individual Feynman diagrams to be computed to subleading orders. Moreover, it is not clear that sums of high-order Feynman diagrams with complicated crisscrossing of lines can lead to factorization implied by the multi-Regge scenario. Both of these difficulties can be overcome by using the recently developed non-Abelian cut diagrams. We are then able to show that the sum of s-channel-ladder diagrams to all orders does lead to such multiple Reggeon exchanges. copyright 1997 The American Physical Society.

UK PubMed Central (United Kingdom)

Much progress has been made in understanding the complex pharmacokinetics of trichloroethylene (TCE). Qualitatively, it is clear that TCE is metabolized to multiple metabolites either locally or into...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Independent component analysis (ICA), an efficient higher order statistics (HOS) based blind source separation technique, has been successfully applied in various fields. In this paper, we provide an overview of the applications of ICA in multiple-input multiple-output (MIMO) wireless communication systems, and introduce some of the important issues surrounding them. First, we present an ICA based blind equalization scheme for MIMO orthogonal frequency division multiplexing (OFDM) systems, with linear precoding for ambiguity elimination. Second, we discuss three peak-to-average power ratio (PAPR) reduction schemes, which do not introduce any spectral overhead. Third, we investigate the application of ICA to blind compensation for inphase/quadrature (I/Q) imbalance in MIMO OFDM systems. Fin...

Science.gov (United States)

These include, but are not limited to: stellar winds and outflows, post-main- sequence stellar evolution, binary/multiple star evolution, globular cluster structure ...

Energy Technology Data Exchange (ETDEWEB)

In order to evaluate dynamic behavior of underground cracks, analysis and detection were attempted on multiple acoustic emission (AE) events. The multiple AE is a phenomenon in which multiple AE signals generated by underground cracks developed in an extremely short time interval are superimposed, and observed as one AE event. The multiple AE signal consists of two AE signals, whereas the second P-wave is supposed to have been inputted before the first S-wave is inputted. The first P-wave is inputted first, where linear three-dimensional particle movements are observed, but the movements are made random due to scattering and sensor characteristics. When the second P-wave is inputted, the linear particle movements are observed again, but are superimposed with the existing input signals and become multiple AE, which creates poor S/N ratio. The multiple AE ...

UK PubMed Central (United Kingdom)

During a high speed road traffic accident, a 26-year-old man suffered multiple fractures of his thoracic vertebrae and bilateral pneumothoraces. The day after admission and commencement of nasogastric...Full Text Available

UK PubMed Central (United Kingdom)

Training of health professionals commonly involves multiple sites in order to best utilize the available clinical material. However, this makes it difficult to achieve continuity in the presentation...Full Text Available

Science.gov (United States)

The highly variable and intermittent pollutant concentrations and flowrates associated with wet-weather events in combined sewersheds necessitates the use of storage-treatment systems to control pollution.An optimized combined-sewer-overflow (CSO) control system requires a manage...

Energy Technology Data Exchange (ETDEWEB)

An essential part of fire risk assessment is the analysis of fire hazards and fire propagation. In this work, models and tools for two different aspects of numerical fire simulation have been developed. The primary objectives have been firstly to investigate the possibility of exploiting state-of-the-art fire models within probabilistic fire risk assessments and secondly to develop a computationally efficient solver of thermal radiation for the Fire Dynamics Simulator (FDS) code. In the first part of the work, an engineering tool for probabilistic fire risk assessment has been developed. The tool can be used to perform Monte Carlo simulations of fires and is called the Probabilistic Fire Simulator (PFS). In Monte Carlo simulation, the simulations are repeated multiple times, covering the whole range of variability of the input parameters and thus resulting in a distribution of results covering what can be expected in reality. In practical applications, advanced ...

International Nuclear Information System (INIS)

The purpose of this paper is to report the personal experience with helical CT evaluation of hepatocellular carcinoma treated with various percutaneous interventional procedures. From December 1996 to September 1998 it were examined with helical CT 41 patients (73 nodules in all) with hepatocellular carcinoma treated with percutaneous ablation therapies: conventional ethanol injection in 18 subjects (31 nodules), one-shot ethanol injection 3 (8 nodules), radiofrequency thermal ablation in 16 (25 nodules), and combined chemo embolization and ethanol injection in 4 (9 nodules). CT performed was 4-27 days after the last session, acquiring biphasic volumetric images in 14 patients and triphasic volumetric images in 27. A second treatment with subsequent CT study was performed for 28 lesions; 15 underwent 3 serial studies and 6 underwent 4 studies. Compared with pretreatment findings, the diameter was unchanged in 62% of the nodules and increased in 38%. Morphology was ...

International Nuclear Information System (INIS)

There are very different views on the health hazards of DU munitions. Most of the concerns of veterans and their advisors focus on the radiological effects of DU and consequently these are the focus of this editorial. Effects on the kidney and environmental consequences are, however, considered in the second of the Royal Society reports and the main conclusions of both of the reports are outlined in the summary document published in this issue of the journal. The main radiological concerns focus on the irradiation of lung tissues from inhaled DU particles and irradiation resulting from the translocation of inhaled particles to the thoracic lymph nodes.The overwhelming scientific view, presented in the two Royal Society reports and in other independent reviews, is that the main risks of exposure to DU aerosols are an increase in lung cancer and (from chemical toxicity) damage to the kidney, although these are likely to be evident only following substantial intakes. The equivalent doses ...

UK PubMed Central (United Kingdom)

BackgroundThe aim of this study was to investigate the anticancer activity and mechanism of action of Noscapine alone and in combination with Doxorubicin against triple negative...Full Text Available

UK PubMed Central (United Kingdom)

Multiple myeloma is a highly radiosensitive skeletal malignancy, but bone-seeking radionuclides have not yet found their place in disease management. We previously reported that the proteasome inhibitor...Full Text Available

Science.gov (United States)

We introduce a discrete multiplicative process as a generic model of competition. Players with different abilities successively join the game and compete for finite resources. Emergence of dominant players and evolutionary development occur as a phase transition. The competitive dynamics underlying this transition is understood from a formal analogy to statistical mechanics. The theory is applicable to bacterial competition, predicting novel population dynamics near criticality.

Science.gov (United States)

This paper continues, with respect to the transplutonium nuclides, earlier efforts to collate and evaluate data from the scientific literature on the prompt neutron multiplicity distribution from fission and its first moment = ..sigma..nuPnu. The isotopes considered here for which P/sub nu/ and or data (or both) were found in the literature are of americium (Am), curium (Cm), berkelium (Bk), californium (Cf), einsteinium (Es), fermium (Fm), and nobelium (No).

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An analyzer-based X-ray phase-contrast imaging (ABI) setup has been mounted at the Brazilian Synchrotron Light Laboratory (LNLS) for multiple imaging radiography (MIR) purposes. The algorithm employed for treating the MIR data collected at LNLS is described, and its reliability in extracting the distinct types of contrast that can be obtained with MIR is demonstrated by analyzing a test sample (thin polyamide wire). As a practical application, the possibility of studying ophthalmic tissues, corneal sequestra in this case, via MIR is investigated.

Science.gov (United States)

The performance of the leukocyte test area of the new multiple urine test strip, Multistix-10-SG, was evaluated in both field trials and model experiments. The detection limit was found to be adequate for routine purposes. Unspecific reactions are rare and generally indicated by the results of the other test areas. PMID:3572312

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PMID:10860471

KoreaScience (Korea)

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... COMBINATION WHICH DISCUSSES AND ILLUSTRATES THE CONSTRUCTION OF AN EXPLODING BRIDGEWIRE ELECTRO-EXPLOSIVE ...

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Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

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International Nuclear Information System (INIS)

The design characteristic of the autocontrol technique of the combined centrifuge is introduced. Digital technique, vary structure control and interface technique, graphical display techniques, digital communication technique as well as electronic technique are applied in the course of research. Automation in the operation of large scale combined centrifuges and the course of combined test has been realized and it can coordinate with other systems of status monitoring, data collecting and centrifugal force-aerodynamic force matched load automatically

British Library Electronic Table of Contents (United Kingdom)

We study the consumption-portfolio problem in a setting with capital gain taxes and multiple risky stocks to understand how short selling influences portfolio choice with a shorting-the-box restriction. Our analysis uncovers a novel trading flexibility strategy whereby, to minimize future tax-induced trading costs, the investor optimally shorts one of the stocks (or equivalently, buys put options) even when no stock has an embedded gain. Alternatively, an imperfect form of shorting the box can reduce aggregate equity exposure ex post. Given these two short selling strategies, it is common for an unconstrained investor to short some equity while a constrained investor holds a positive investment in all stocks. With no shorting, the benefit of trading separately in multiple stocks is not eco...

Science.gov (United States)

Double streamtube codes model the curved blade (Darrieus-type) vertical axis wind turbine (VAWT) as a double actuator fish arrangement (one half) and use conservation of momentum principles to determine the forces acting on the turbine blades and the turbine performance. Sandia National Laboratories developed a double multiple streamtube model for the VAWT which incorporates the effects of the incident wind boundary layer, nonuniform velocity between the upwind and downwind sections of the rotor, dynamic stall effects and local blade Reynolds number variations. The theory underlying this VAWT model is described, as well as the code capabilities. Code results are compared with experimental data from two VAWT's and with the results from another double multiple streamtube and a vortex filament code. The effects of neglecting dynamic stall and horizontal wind velocity distribution are also illustrated.

CERN Document Server

Cyclotomic fast Fourier transforms (CFFTs) are efficient implementations of discrete Fourier transforms over finite fields, which have widespread applications in cryptography and error control codes. They are of great interest because of their low multiplicative and overall complexities. However, their advantages are shown by inspection in the literature, and there is no asymptotic computational complexity analysis for CFFTs. Their high additive complexity also incurs difficulties in hardware implementations. In this paper, we derive the bounds for the multiplicative and additive complexities of CFFTs, respectively. Our results confirm that CFFTs have the smallest multiplicative complexities among all known algorithms while their additive complexities render them asymptotically suboptimal. However, CFFTs remain valuable as they have the smallest overall complexities for most practical lengths. Our additive complexity ...

British Library Electronic Table of Contents (United Kingdom)

An efficient micropropagation protocol was established for Cryptocoryne wendtii and Cryptocoryne becketti using shoot tips explants. Multiple shoots were induced from shoot tip explants of both species cultured on agar-gelled as well as liquid MS medium supplemented with 0.5?mg/L BA and 0.2?mg/L IBA (proliferation medium). The multiple shoots of both the species formed on agar-gelled as well as liquid medium were vigorously growing with well-developed roots and leaves after 4?weeks of culture. Highest number of multiple shoots was obtained from shoot tip explants of both the species cultured in liquid proliferation medium after 4?weeks of culture. The shoot tip explants of C. wendtii and C. becketti, that were cultured in liquid proliferation medium (2?weeks) followed by culturing on agar-...

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The Petroleum Technology Transfer Council (PTTC) and cooperating Regional Lead Organizations (RLOs) in its South Midcontinent (Oklahoma Geological Survey, Norman, Oklahoma) and West Coast (University of Southern California, Los Angeles, California) regions conducted a ''Mentor-Based Effort to Advance Implementation of Preferred Management Practices (PMPs) For Oil Producers'' (DE-FC26-01BC15272) under an award in Phase I of Department of Energy's (DOE's) PUMP (Preferred Upstream Management Practices) program. The project's objective was to enable producers in California, Oklahoma and Arkansas to increase oil production, moderating or potentially reversing production declines and extending the life of marginal wells in the near term. PTTC identified the primary constraints inhibiting oil production through surveys and PUMPer direct contacts in both regions. The leading common constraint was excess produced water and ...

Energy Technology Data Exchange (ETDEWEB)

Concepts involving combined gas-turbine/steam-turbine power-generation plants, in which the fuel gas for the gas turbine is produced via the gasification of coal, are now extremely advanced. This technology already permits efficiencies of around 50% current development targets view 65% as achievable. In conventional technology, efficiencies are tied to conditions, such as air and cooling-water temperatures, at the particular location. In combined-cycle power plants, the properties of the fuel coal also play an important part. There are, in face, coals which can be more advantageously used in a combined-cycle power plant than in a conventional one. These differences, combined with advantageous concepts for coal-fired combined-cycle power-generating plants, are presented and analyzed. Particular attention is devoted to individual losses occurring at coal conversion, thermodynamic ...

UK PubMed Central (United Kingdom)

Computational methods for determining the secondary structure of RNA sequences from given alignments are currently either based on thermodynamic folding, compensatory base pair substitutions or both....Full Text Available

UK PubMed Central (United Kingdom)

Femur fractures typically affect elderly patients with multiple co-morbidities. Pain control can be difficult, requiring intensive nursing and physician care as elderly patients may manifest cardiovascular...Full Text Available

UK PubMed Central (United Kingdom)

Thioredoxin, a small, ubiquitous protein which participates in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, is an essential protein in Bacillus...Full Text Available

UK PubMed Central (United Kingdom)

Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at...Full Text Available

UK PubMed Central (United Kingdom)

Six genes involved in the heparan sulfate and heparin metabolism pathway, DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1...Full Text Available

UK PubMed Central (United Kingdom)

CBP and its paralog p300 are histone acetyl transferases that regulate gene expression by interacting with multiple transcription factors via specialized domains. The structure...Full Text Available

UK PubMed Central (United Kingdom)

Photosynthetic (Ps) electron transport pathways often contain multiple electron carriers with overlapping functions. Here we focus on two c-type cytochromes (cyt) in facultative phototrophic...Full Text Available

UK PubMed Central (United Kingdom)

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

UK PubMed Central (United Kingdom)

SummaryThe structure and function of myosin crossbridges in asynchronous insect flight muscle (IFM) have been elucidated in situ using multiple approaches. These...Full Text Available

UK PubMed Central (United Kingdom)

The specific white matter location of all the spinal pathways conveying penile input to the rostral medulla is not known. Our previous studies using rats demonstrated the loss of low but not high threshold...Full Text Available

UK PubMed Central (United Kingdom)

Contemporary high dimensional biological assays, such as mRNA expression microarrays, regularly involve multiple data processing steps, such as experimental processing, computational processing, sample...Full Text Available

CERN Document Server

Automatic Repeat Request (ARQ) is an effective technique for reliable transmission of packets in wireless networks. In ARQ, however, only a few erroneous bits in a packet will cause the entire packet to be discarded at the receiver. In this case, it's wasteful to retransmit the correct bit in the received packet. The partial packet recovery only retransmits the unreliable decoded bits in order to increase the throughput of network. In addition, the cooperative transmission based on Interleave-division multiple-access (IDMA) can obtain diversity gains with multiple relays with different locations for multiple sources simultaneously. By exploring the diversity from the channel between relay and destination, we propose a relay-assisted partial packet recovery in CDMA wireless network to improve the performance of throughput. In the proposed scheme, asynchronous IDMA iterative chip-by-chip multiuser detection is utilized as a ...

UK PubMed Central (United Kingdom)

A large percentage of patients with HIV/AIDS will develop dermatological complications. Consequently, all practising clinicians and pathologists in regions with a high prevalence of HIV/AIDS must be...Full Text Available

UK PubMed Central (United Kingdom)

Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable...Full Text Available

UK PubMed Central (United Kingdom)

Polyandrous mating is common, but the benefits for females of polyandry remain controversial. To test whether mating with multiple males affects female fitness, we compared lifetime components of fitness...Full Text Available

UK PubMed Central (United Kingdom)

Current military conflicts in Iraq and Afghanistan have produced a significant number of complex injury patterns. Multiple extremity trauma and wide zones of injury mandate a flexible approach to these...Full Text Available

UK PubMed Central (United Kingdom)

Adaptive radiation is the rapid origination of multiple species from a single ancestor as the result of concurrent adaptation to disparate environments. This fundamental evolutionary process is considered...Full Text Available

Science.gov (United States)

Cadmium telluride single crystals were subjected to multiple-energy boron ion implants with total doses up to 1.5 x 10 sq cm. Various diagnostic techniques were used to assess the structural and electronic properties of these crystals in their as-implante...

UK PubMed Central (United Kingdom)

In this study we use the multiple indicator dilution technique to outline the kinetic mechanisms underlying the uptake of rubidium, a cation which, in the steady state, is concentrated by hepatic parenchymal...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundZhx1 to 3 (zinc-fingers and homeoboxes) form a set of paralogous genes encoding multi-domain proteins. ZHX proteins consist of two zinc fingers followed...Full Text Available

UK PubMed Central (United Kingdom)

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected to the process of tumorogenesis based on a multiplicity of evidence. (1)...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Eddy current inspection methods are widely used for the nondestructive evaluation (NDE) of tubular products. Specifically, the sensors and instrumentation are designed to detect and characterize changes in a material's electrical and magnetic properties produced by the presence of discontinuities. A recent major enhancement in eddy current inspection technology has been the development of computer interfacing for data collection, analysis, and display. This breakthrough has led to multiple-frequency testing, eddy current imaging, and automated data interpretation systems that significantly enhance both capabilities and reliability of the eddy current inspection. In addition to the clear advantages in data processing, computer interfacing also permits the design and creation of unique sensors that further enhance eddy current inspection capabilities. Perhaps the most promising area of computer interactive probe design is multiple ...

UK PubMed Central (United Kingdom)

Congenital deformities involving the coverings of the nervous system are called neural tube defects (NTDs). NTD can be classified as neurulation defects, which occur by stage 12, and postneurulation...Full Text Available

UK PubMed Central (United Kingdom)

The integration sites for viral DNA in cells infected with Moloney murine leukemia virus (M-MuLV) were studied by restriction endonuclease cleavage of cellular DNA followed by electrophoresis in agarose...Full Text Available

UK PubMed Central (United Kingdom)

The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the 40S ribosomal subunit and also localizes to the cell membrane to interact with the extracellular matrix. LAMR...Full Text Available

UK PubMed Central (United Kingdom)

Twelve isolates of Enterobacteriaceae (1 of Klebsiella pneumoniae, 8 of Escherichia coli, 1 of Proteus mirabilis, and 2 of Proteus...Full Text Available

UK PubMed Central (United Kingdom)

Bartonella species are being recognized as important bacterial human and canine pathogens, and are associated with multiple arthropod vectors. Bartonella DNA extracted...Full Text Available

UK PubMed Central (United Kingdom)

Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been implicated in Multiple Sclerosis demyelination through activation of complement and/or macrophage-effector processes. We presented...Full Text Available

UK PubMed Central (United Kingdom)

Circuit modification associated with learning and memory involves multiple events, including the addition and remotion of newborn cells trough adulthood. Adult neurogenesis and gliogenesis were mainly...Full Text Available

UK PubMed Central (United Kingdom)

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes...Full Text Available

UK PubMed Central (United Kingdom)

Multiple stimuli present in the visual field at the same time compete for neural representation by mutually suppressing their evoked activity throughout visual cortex, providing a neural correlate...Full Text Available

International Nuclear Information System (INIS)

Protocols were standardized for in vitro propagation of several elite and diverse banana accessions using shoot tip explants. Tissue culture raised plants were field planted at multiple locations. Studies were undertaken for the induction of mutations using multiple shoot cultures of six selected cultivars, Shreemanti (AAA), Basrai (AAA), Lal Kela (AAA), Rasthali (AAB), Karibale Monthan (ABB) and a wild diploid (BB). These shoot cultures were irradiated at different doses of gamma rays (0-100 Gy) and subcultured thrice (up to M_1V_3) to separate shimeras, followed by induction of rooting (M_1V_4). In general, the rate of multiplication had a negative association with the dose of gamma rays. Enhanced multiplication of shoots was noticed at lower doses. The proliferation of shoots was arrested beyond 50 Gy and a dose of 70 Gy was completely lethal for all the genotypes studied. The rooted plantlets were ...

UK PubMed Central (United Kingdom)

The plasmid pE194 (3.7 kilobases) is capable of integrating into the genome of the bacterial host Bacillus subtilis in the absence of the major homology-dependent RecE recombination system. Multiple...Full Text Available

UK PubMed Central (United Kingdom)

AbstractMultiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype...Full Text Available

Science.gov (United States)

... 1 8.53 1.5448 2 12.45 2.1944 3 16.59 2.5224 Sensor Mobility fixed 8.92 1.9312 mobile 12.15 2.3625 Display Configuration conv. 10.92 1.7981 ...

UK PubMed Central (United Kingdom)

The identification of host cell factors for virus replication holds great promise for the development of new anti-viral therapies. Recently, high-throughput screening methods have emerged as...Full Text Available

UK PubMed Central (United Kingdom)

Drosophila neuroblasts divide asymmetrically by aligning their mitotic spindle with cortical cell polarity to generate distinct sibling cell types. Neuroblasts asymmetrically localize...Full Text Available

UK PubMed Central (United Kingdom)

Background:Stem cells can differentiate into multiple cell types, and therefore can be used for cellular therapies, including tissue repair. However, the participation of stem cells...Full Text Available

UK PubMed Central (United Kingdom)

Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task...Full Text Available

Science.gov (United States)

... Volume(s) Volume(s) II Item Identification 1,2,3,4, JANAP Joint Army-Navy- 2,7 5,6,13 Air Force JIM Item Intelligence 2 Publication Maintenance ...

UK PubMed Central (United Kingdom)

BackgroundChitin synthase 3a (CHS3a) from Botrytis cinerea (Bc) catalyses the multiple transfer of N-acetylglucosamine (GlcNAc) residues to the...Full Text Available