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Sample records for 2004-5 pelotas rs

  1. Metodologia do estudo da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Metodologia de estudio de la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Methodology of the Pelotas birth cohort study from 1982 to 2004-5, Southern Brazil

    Fernando C Barros

    2008-12-01

    Full Text Available OBJETIVO: Descrever os métodos utilizados no estudo longitudinal e acompanhamento das crianças nascidas em Pelotas (RS em 1982. MÉTODOS: A coorte foi iniciada com um inquérito de saúde perinatal de todas as 6.011 crianças nascidas nas maternidades de Pelotas em 1982. As 5.914 crianças nascidas vivas foram incluídas nos estudos de acompanhamento. Até 2004-5 foram realizados oito acompanhamentos, com a aplicação de questionários às mães e/ou aos membros da coorte, conforme a faixa etária. Exames antropométricos e clínicos foram realizados nas visitas. Os participantes da coorte são descritos conforme variáveis demográficas, socioeconômicas e de saúde colhidas nos primeiros acompanhamentos, que são utilizadas como variáveis de exposição. RESULTADOS: A maior parte dos jovens da coorte foram acompanhados durante 23 anos de vida e distintas visitas. Os acompanhamentos que obtiveram maior êxito foram aqueles precedidos por um censo da cidade. Com este método foram localizados 87,2% em 1984 (idade média de 19 meses, 84,1% em 2006 (média 43 meses, e 77,4% em 2004-5 (média 23 anos. CONCLUSÕES: Estudos de coorte de nascimentos podem ser realizados com sucesso em países em desenvolvimento, e a metodologia empregada nesses estudos de ciclo vital permite estudar a influência de exposições precoces sobre a determinação das doenças da vida adulta.OBJETIVO: Describir los métodos utilizados en el estudio longitudinal y acompañamiento de los niños nacidos en Pelotas (Sur de Brasil en 1982. MÉTODOS: La cohorte fue iniciada con una investigación de salud perinatal de todos los 6.011 niños nacidos en las maternidades de Pelotas en 1982. Los 5.914 niños nacidos vivos fueron incluidos en los estudios de acompañamiento. Hasta 2004-5 fueron realizados ocho acompañamientos, con la aplicación de cuestionarios a las mamás y/o a los miembros de la cohorte conforme el rango de edad. Exámenes antropométricos y cl

  2. Maternidade e paternidade na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Maternidad y paternidad en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Maternity and paternity in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Descrever a prevalência de maternidade e paternidade em adultos jovens e sua associação com variáveis perinatais, socioeconômicas e demográficas. MÉTODOS: Os participantes foram jovens com idade média de 23 anos, acompanhados em estudo de coorte desde o seu nascimento, em 1982, em Pelotas (RS e entrevistados em 2004-5. Foram considerados elegíveis os jovens que referiram ter tido um ou mais filhos, nascidos vivos ou mortos. Dois questionários foram aplicados para coletar informações sobre saúde reprodutiva, dados socioeconômicos e demográficos. As variáveis independentes foram sexo e cor da pele, renda familiar em 1982 e 2004-5, mudança de renda, peso ao nascer do jovem e escolaridade aos 23 anos. Análises brutas e ajustadas foram realizadas por meio de regressão de Poisson para investigar os efeitos das variáveis independentes sobre a maternidade/paternidade na adolescência. RESULTADOS: De 4.297 jovens entrevistados, 1.373 (32% eram mães ou pais, dos quais 842 (19,6% haviam experimentado a maternidade/paternidade na adolescência. O planejamento da gravidez do primeiro filho mostrou relação direta com a idade do jovem. Relação inversa foi observada entre as variáveis socioeconômicas e a ocorrência de maternidade/paternidade na adolescência. A probabilidade de ser mãe na adolescência foi maior entre as mulheres pretas ou pardas, mas a cor da pele não esteve associada com a paternidade na adolescência. CONCLUSÕES: Houve forte relação entre a maternidade/paternidade na adolescência e condições socioeconômicas, a qual deve ser considerada no delineamento de ações preventivas no campo da saúde pública.OBJETIVO: Describir la prevalencia de maternidad y paternidad en adultos jóvenes y su asociación con variables perinatales, socioeconómicas y demográficas. MÉTODOS: Los participantes fueron jóvenes con edad promedio de 23 años, acompañados en estudio de cohorte desde su nacimiento, en 1982

  3. Determinantes sociais da iniciação sexual precoce na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Determinantes sociales de la iniciación sexual precoz en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Determinants of early sexual initiation in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Helen Gonçalves

    2008-12-01

    Full Text Available OBJETIVO: Analisar determinantes sociais da iniciação sexual precoce de jovens pertencentes a uma coorte de nascimentos. MÉTODOS: Foram entrevistados em 2004-5 os indivíduos da coorte de nascimentos de Pelotas (RS, em 1982 (N=4.297. A iniciação sexual precoce (OBJETIVO: Analizar las determinantes sociales de la iniciación sexual precoz de jóvenes pertenecientes a una cohorte de nacimientos. MÉTODOS: Fueron entrevistados en 2004-5 los individuos de la cohorte de nacimientos de Pelotas (Sur de Brasil, en 1982 (N= 4.297. La iniciación sexual precoz (OBJECTIVE: To analyze social determinants of early sexual initiation among young adults from a birth cohort. METHODS: Individuals from the 1982 birth cohort (N=4,297 were interviewed in 2004-5, city of Pelotas, Southern Brazil. Early sexual initiation (<13 years of age was the outcome. Descriptive and stratified analyses were performed according to sex. Variables analyzed were family income in 1982, ethnicity, young adult's level of education and change in income (between 1982 and 2004-5. Ethnographic data were used to complement result analysis. RESULTS: Prevalence of early sexual initiation was higher among black and mixed men, and those with low level of education and low family income in 1982 and 2004-5. More traditional male sexual role requirements, such as virility and sexual initiative, showed more repercussion and adherence from an early age among men. Young family women with higher income and level of education tended to delay their sexual initiation. Imposition of traditional values was found to influence early sexual initiation among men and women with lower level of education and income. CONCLUSIONS: Results found re-established the economic factor as a determinant of behavior or uses of sexuality for both sexes. To focus on political efforts that help the economically disadvantaged to have opportunities and egalitarian future perspectives is an important strategy for health

  4. Educação e trabalho na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Educación y trabajo en la cohorte de nacimientos de 1982 a 2005, Pelotas, Sur de Brasil Education and work in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Fernando C Barros

    2008-12-01

    Full Text Available OBJETIVO: Analisar a influência de fatores socioeconômicos e biológicos precoces ao longo da vida sobre o ingresso na universidade e a inserção no mercado de trabalho dos jovens da coorte de nascimento de 1982. MÉTODOS: Estudo longitudinal de 5.914 nascimentos da cidade de Pelotas (RS, em 1982. Utilizando-se questionários aplicados ao jovem, foram coletadas informações sobre nível educacional e a inserção no mercado de trabalho durante acompanhamento da coorte realizado em 2004-5. Regressão de Poisson foi utilizada para estudar o efeito de variáveis demográficas, socioeconômicas, peso ao nascer e aleitamento materno sobre os desfechos. RESULTADOS: A escolaridade média foi de 9,4 anos (± 3,1 e 42% dos jovens estavam freqüentando a escola em 2004-5. Um de cada cinco jovens havia ingressado na universidade e cerca de dois terços estavam trabalhando no mês anterior à entrevista. O ingresso na universidade foi determinado pelas condições econômicas, e teve influência do peso ao nascer nas mulheres e da amamentação nos homens. A inserção no mercado de trabalho foi mais freqüente entre os homens mais pobres, mas não para as mulheres. CONCLUSÕES: A baixa inclusão universitária e a necessidade de inserção no mercado de trabalho dos jovens de famílias mais pobres mantêm um círculo vicioso que reproduz a hierarquia social dominante.OBJETIVO: Analizar la influencia de factores socioeconómicos y biológicos precoces a lo largo de la vida sobre el ingreso en la universidad y la inserción en el mercado de trabajo de los jóvenes de la cohorte de nacimiento de 1982. MÉTODOS: Estudio longitudinal de 5.914 nacimientos de la ciudad de Pelotas (Sur de Brasil, en 1982. Utilizándose cuestionarios aplicados al joven, fueron colectadas informaciones sobre el nivel educacional y la inserción en el mercado de trabajo durante acompañamiento de la cohorte realizado en 2004-5. Regresión de Poisson fue utilizada para estudiar el

  5. Utilização de serviços de saúde por adultos da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Utilización de servicios de salud por adultos de la cohorte de nacimientos de 1982 a 2005, Pelotas, Sur de Brasil Pattern of health services utilization by adults of the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Juvenal S Dias-da-Costa

    2008-12-01

    Full Text Available OBJETIVO: Descrever o padrão de utilização de serviços de saúde por adultos jovens. MÉTODOS: Estudo longitudinal em Pelotas (RS, em que os indivíduos foram localizados no seu nascimento em 1982 e acompanhados até os 23 anos. O desfecho foi definido por informações coletadas sobre consultas com profissionais de saúde realizadas no ano anterior à entrevista entre 2004 e 2005. Os locais de consulta foram categorizados como públicos, privados ou planos de saúde. Análises descritivas foram realizadas para utilização e tipo de serviço de saúde. Regressão de Poisson foi utilizada na análise ajustada. RESULTADOS: Dos entrevistados, 72,0% tiveram consulta com profissionais de saúde no ano anterior à entrevista; 86,2% (IC 95% 84,7;87,7 das mulheres e 59,3% (IC 95% 57,3;61,3 dos homens. Mesmo quando excluídas as consultas com ginecologista, as mulheres continuavam tendo mais consultas do que os homens, 68,4% (IC 95% 66,4;70,4. A utilização dos serviços de saúde foi mais freqüente entre os entrevistados de melhor nível socioeconômico. Diferença de menor uso em relação à cor da pele não branca foi observada somente entre os jovens do sexo masculino. Houve diferenças em relação ao tipo de profissional consultado por homens e mulheres e também conforme a renda familiar. Homens e mulheres consultaram mais freqüentemente o sistema público, os serviços conveniados e em menor proporção o sistema privado. CONCLUSÕES: A situação socioeconômica influenciou a utilização e o tipo de serviço de saúde, com homens e mulheres classificados como "pobres no momento", indicando menor utilização de serviços. Tais diferenças socioeconômicas podem ser indicativas de dificuldades de acesso ao sistema de saúde.OBJETIVO: Describir el patrón de utilización de servicios de salud por adultos jóvenes. MÉTODOS: Estudio longitudinal en Pelotas (Sur de Brasil, en que los individuos fueron localizados en su nacimiento en 1982 y

  6. Methodological aspects of the 1993 Pelotas (Brazil birth cohort study Aspectos metodológicos da coorte de nascimentos de 1993 em Pelotas, RS

    Cesar Gomes Victora

    2006-02-01

    Full Text Available This paper describes the main methodological aspects of a cohort study, with emphasis on its recent phases, which may be relevant to investigators planning to carry out similar studies. In 1993, a population based study was launched in Pelotas, Southern Brazil. All 5,249 newborns delivered in the city's hospitals were enrolled, and sub-samples were visited at the ages of one, three and six months and of one and four years. In 2004-5 it was possible to trace 87.5% of the cohort at the age of 10-12 years. Sub-studies are addressing issues related to oral health, psychological development and mental health, body composition, and ethnography. Birth cohort studies are essential for investigating the early determinants of adult disease and nutritional status, yet few such studies are available from low and middle-income countries where these determinants may differ from those documented in more developed settings.Descrever aspectos metodológicos do estudo da coorte de crianças que podem ser relevantes para pesquisadores que estejam planejando investigações semelhantes. Em 1993, uma coorte de base populacional foi recrutada em Pelotas, RS. Os 5.249 recém-nascidos nos hospitais da cidade foram acompanhados com um, três e seis meses, e com um e quatro anos de idade. Subestudos estão sendo realizados sobre saúde bucal, desenvolvimento psicológico e saúde mental, composição corporal e aspectos etnográficos. Em 2004-5 foi possível entrevistar 87,5% da coorte inicial, com a idade de 10-12 anos. Estudos de coortes de nascimentos são essenciais para investigar os determinantes precoces da morbidade e estado nutricional de adultos. No entanto, há poucos estudos com esta metodologia em países de renda média e baixa, e alguns dos determinantes da situação de saúde podem ser distintos daqueles observados em países ricos.

  7. Ovulações múltiplas em éguas abatidas em Pelotas-RS Multiple ovulation in slaughtered mares - Pelotas-RS

    Claudio Alves Pimentel; Adriana Kroef Tarouco; Anelise Maria Harnmes

    1995-01-01

    O presente trabalho descreve a frequência de ovulações múltiplas em 3631 éguas, abatidas em Pelotas - RS, durante o período de janeiro de 1988 a setembro de 1989, com a predominância de sangue da raça Crioula. A maior frequência de ovulações múltiplas ocorreu no mês de fevereiro (19%), diminuindo progressivamente até setembro (0,4%). Este resultado mostra que o fotoperíodo exerce uma influência positiva sobre a atividadc ovariana, inclusive no que tange ao número de ovulações por ciclo. A fre...

  8. Uma Proposta de Planejamento Turístico e sua Aplicação em Pelotas, RS

    Fabiano Milano Fritzen

    2015-10-01

    Full Text Available Este artigo apresenta experiência planejamento turístico em Pelotas, RS, conduzida pelo Grupo Gestor (GG, seguindo ações do Programa de Regionalização do Turismo do Ministério do Turismo. Realizado o diagnóstico, os integrantes do GG Pelotas participaram da análise e tomada de decisão seguindo estratégias para a consolidação de destino, considerando-se as 13 dimensões descritas no estudo. Utilizou-se uma aproximação à pesquisa-ação, com abordagem quali-quantitativa e descritiva, para desenvolver o planejamento em questão. Houve quatro etapas de capacitação, utilizando-se a análise SWOT para sua construção. A partir do diagnóstico, realizou-se a hierarquização das variáveis através da Matriz de Densidade. Dessa forma, foram conhecidas as estratégias prioritárias ao planejamento de Pelotas como destino turístico, fornecendo a base para a construção do plano de ação, o qual não se efetivou. A experiência trouxe aspectos positivos como a articulação dos atores para o desenvolvimento do turismo local, motivando reflexões a respeito da condução das políticas nacionais de Turismo. Palavras-chave: Turismo. Política de Turismo. Planejamento Turístico. Pelotas, RS. A Proposal for Tourism Planning and Its Application in Pelotas, Brazil -  The planning was motivated by the actions of Tourism Regionalization Program (MTUR . From the diagnostic “Competitive Study Pelotas”, the members of the MG Pelotas were  mobilized to the analysis and decision making about the variables and dimensions of the study and the collaborative construction of strategies to  consolidate the destination. It was used research-action with a quali-quantitative and descriptive approach to develop this collaborative work between different local actors. It was made in four steps, through capacitating modules, and with the use of the analysis SWOT for its construction. From a local reality diagnostic about the 13 dimensions described in

  9. Ovulações múltiplas em éguas abatidas em Pelotas-RS Multiple ovulation in slaughtered mares - Pelotas-RS

    Claudio Alves Pimentel

    1995-01-01

    Full Text Available O presente trabalho descreve a frequência de ovulações múltiplas em 3631 éguas, abatidas em Pelotas - RS, durante o período de janeiro de 1988 a setembro de 1989, com a predominância de sangue da raça Crioula. A maior frequência de ovulações múltiplas ocorreu no mês de fevereiro (19%, diminuindo progressivamente até setembro (0,4%. Este resultado mostra que o fotoperíodo exerce uma influência positiva sobre a atividadc ovariana, inclusive no que tange ao número de ovulações por ciclo. A frequência média geral de ovulações múltiplas foi 7,1% (257/3631. A taxa média de ovulações duplas foi de 6,5% (235/3631, tripla de 0,5% (19/3631 e quádrupla, 0,1% (3/3631. Os meses de dezembro a abril mostraram as maiores frequências sobre o total das ovulações múltiplas (65,5%. Estas informações podem representar um importante subsídio ao manejo reprodutivo da raça crioula, visando controlar o sério problema que as gestações gemelares representam na espécie equina.This paper describes the frequency of multiple ovulations in 3631 mares, slaughtered in Pelotas - RS, predominantly from Crioulo breed. The higher frequency of multiple ovulation ocurred in February (19%, decreasing progressively up to September (0.4%. This result shows that the photoperiod has a positive influence on the ovarian activity, even on the number of ovulations per cycle. The overall mean of multiple ovulation was 7.1% (257/3631. Double ovulations ocurred in 6.5% (235/3631, triple in 0.5% (19/3631 and quadruple in 0.1% (3/3631. The months from December to April presented the highest frequencies over all multiple ovulations (65.5%. These observations may represent an importante support to reproductive management of the Crioulo breed in order to control the serious problem that represents twin pregnancies in equine.

  10. IMPACTOS DO TURISMO NA CIDADE DE PELOTAS/RS, SEGUNDO A COMUNIDADE LOCAL.

    Dalila Rosa Hallal

    2013-12-01

    Full Text Available O fenômeno atual do rápido crescimento do turismo no mundo vem trazendo algumas importantes reflexões para governos, mercados, pesquisadores, ambientalistas e comunidades. Sabe-se que o turismo pode contribuir sensivelmente para o desenvolvimento sócio-econômico e cultural de amplas regiões e, ao mesmo tempo, em poucos anos, pode degradar o ambiente natural, as estruturas sociais e a herança históricocultural dos povos. Historicamente, é notável o poder das cidades de atrair visitantes. “É uma obra de arte viva e seus atores são seus habitantes. Há cores e odores. Hábitos e costumes. História e memória.” (WAINBERG, 2000, p.13. Com base nestas questões, o presente trabalho tem por objetivo analisar, a partir da comunidade local de Pelotas, as vantagens e desvantagens da atividade turística para a cidade. A coleta de dados foi realizada no município de Pelotas/RS através de entrevistas semiestruturadas com a comunidade local. Este estudo possibilitou a identificação dos principais impactos (econômicos, sociais, ambientais e culturais do turismo na cidade de Pelotas a partir da comunidade local. Os sujeitos identificaram vantagens e desvantagens da atividade turística, sendo as vantagens econômicas e as desvantagens ambientais as mais citadas nas entrevistas

  11. Esporotricose felina com envolvimento humano na cidade de Pelotas, RS, Brasil Feline sporotrichosis with human envolvement in Pelotas city, RS, Brazil

    Melissa Orzechowski Xavier

    2004-12-01

    Full Text Available A esporotricose é uma micose subcutânea, causada pelo fungo dimórfico Sporothrix schenckii. O presente estudo descreve a ocorrência de esporotricose felina na cidade de Pelotas (Rio Grande do Sul - Brasil, e a transmissão para um atendente da clínica veterinária, ocasionada pela arranhadura do animal doente. O felino apresentava deformação do espelho nasal e lesões cutâneas, enquanto o humano apresentava uma lesão ulcerada na região metacarpiana dorsal esquerda. Foram colhidas crostas e/ou exsudato das lesões do felino e do atendente para diagnóstico micológico, os quais foram cultivados em ágar Sabouraud dextrose acrescido de cloranfenicol e incubados a 25 e 37°C, durante 10 dias. O isolamento do S. schenckii confirmou o diagnóstico clínico de esporotricose cutânea disseminada no felino e cutânea localizada no atendente. Esta nota pretende alertar profissionais relacionados à clínica de pequenos animais quanto à existência da doença e o alto risco de transmissão pela mordedura e/ou arranhadura de animais infectados.The sporotrichosis is one subcutaneous mycosis, produced by the dimorphic fungi Sporothrix schenckii. The present study describes the occurrence of feline sporotrichosis in Pelotas city, RS, Brazil. The disease was transmitted to an attendAnt of the veterinary clinic. The transmission was caused by scratching of the infected animal. The feline showed deformity of the nasal plane and cutaneous lesions, and the attendAnt presented one single ulcerated lesion on the dorsal left metacarpus. The mycological diagnostic was made by eschaps and/or exsudate from the feline and the attendAnt. The samples were cultivated on agar Sabouraud dextrose with chloramphenicol at 25 and 37°C during ten days. As S. schenckii was isolated from the samples, the diagnostic of disseminated cutaneous sporotrichosis by the feline and cutaneous localized sporotrichosis by the clinician, was confirmed. This note has the aim to alert

  12. Use of information systems in a health institution of Pelotas/RS

    Isabel Cristina Rosa Barros Rasia

    2012-01-01

    Full Text Available This case study was conducted at a single institution Health Pelotas / RS and aimed to describe some of the subsystems of health information used in this institution, in addition to emphasizing the importance of proper record of information, so that they can be used by managers in the construction Indicators of Health was conducted qualitative research with the chief Nurse of the Unit in April 2011, and the data were investigated by content analysis. We stress the importance of this work proper record of information for the construction of reliable health indicators. The information and teamwork and interaction dimensions of organizational, technological and human, provide an excellent service more dignified and humane that will benefit everyone involved. We conclude that there must be an organizational culture of valuing information, and to know and assess the extent and performance of each information system is extremely important for your use and continuous improvement, becoming an instrument to detect priority focus of attention.

  13. Prevalência e determinantes precoces dos transtornos mentais comuns na coorte de nascimentos de 1982, Pelotas, RS Prevalencia y determinantes precoces de los trastornos mentales comunes en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence and early determinants of common mental disorders in the 1982 birth cohort, Pelotas, Southern Brazil

    Luciana Anselmi

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de transtornos mentais comuns e sua associação com fatores de risco numa coorte de adultos jovens. MÉTODOS: Estudo transversal aninhado à coorte de nascimentos de 1982 de Pelotas, RS. Em 2004-5, 4.297 indivíduos foram entrevistados em visita domiciliar. A probabilidade de transtornos mentais comuns foi estimada pelo Self-Report Questionnaire. Os fatores de risco incluíram variáveis socioeconômicas, demográficas, perinatais e ambientais. A análise foi estratificada por sexo e as razões de prevalência simples e ajustadas foram estimadas utilizando-se regressão de Poisson. RESULTADOS: A prevalência de transtornos mentais comuns na população geral foi 28,0%; 32,8% e 23,5%, respectivamente, entre mulheres e homens. Independentemente da pobreza em 1982, homens e mulheres pobres em 2004-5 apresentaram risco aproximado de 1,5 para esses transtornos (pOBJETIVO: Estimar la prevalencia de trastornos mentales comunes y su asociación con factores de riesgo en una cohorte de adultos jóvenes. MÉTODOS: Estudio transversal anidado a la cohorte de nacimientos de 1982 de Pelotas (Sur de Brasil. En 2004-5, 4.297 individuos fueron entrevistados en visita domiciliar. La probabilidad de trastornos mentales comunes fue estimada por el Self-Report Questionnaire. Los factores de riesgo incluyeron variables socioeconómicas, demográficas, perinatales y ambientales. El análisis fue estratificado por sexo y las razones de prevalencia simples y ajustadas fueron estimadas utilizándose regresión de Poisson. RESULTADOS: La prevalencia de trastornos mentales comunes en la población general fue de 28,0%; 32,8% y 23,5%, respectivamente, entre mujeres y hombres. Independientemente de la pobreza en 1982, hombres y mujeres pobres en 2004-5 presentaron riesgo aproximado de 1,5 para esos trastornos (pOBJECTIVE: To estimate the prevalence of common mental disorders and assess its association with risk factors in a cohort of young

  14. Neogene Palynomorphs from the 2-CA-1-RS Well, Pelotas Basin, Brazil: Biostratigraphic and Paleoecological Significance

    Wagner Guimarães da Silva

    2011-04-01

    Full Text Available There is information available on calcareous microfossils found in the pre-Quaternary section of the Pelotas Basin.However, there is relatively sparse palynological data, since palynological studies only started to be systematicallyconducted in the last years. This paper presents palynological results regarding 20 samples collected between depths of262-145 m in the 2-CA-1-RS well, which is located in the onshore portion of this basin, in the Rio Grande do Sul state. Fivesamples showed rich and diverse associations of palynomorphs and fifteen samples showed a predominance of amorphousorganic matter or phytoclasts. Species of spores, pollen grains, dinoflagellate cysts, as well as microforaminiferal linigs,scolecodonts, acritarchs, Chlorococcales algae (Botryococcus and fungal spores were also identified in this study.Quantitative analysis on the distribution of particulate organic matter along the section allowed the identification oftwo palynological assemblages. The results indicate marine paleoenvironments, varying from the bottom to the top, forthe studied section. Assemblage 1 (262 – 248 m is interpreted as distal marine environment in open ocean, whereasAssemblage 2 (190 – 160 m is associated with proximal marine environments. The stratigraphic range of certain speciesof dinoflagellate cysts indicates ages ranging from the Miocene to the Quaternary.

  15. Frequency of geohelminths in public squares in Pelotas, RS, Brazil Frequência de geohelmintos em praças públicas de Pelotas, RS, Brasil

    Micaele Quintana de Moura

    2013-03-01

    Full Text Available The frequency of parasitic contamination of public areas in the municipality of Pelotas, state of Rio Grande do Sul, Brazil, was studied between June 2010 and May 2011, when soil samples were collected from eight city squares. Out of 400 samples submitted to centrifugal floatation technique in solution of sodium dichromate with density of 1.35, 176 (44% proved positive for at least one parasite; 29 (16.5% samples were multi-infested. The results showed that there was a significant soil contamination rate in all the parks included in the study. The positivity rate was higher for hookworms eggs (13.5% and Toxocara eggs (8.8%; Trichuris, Ascaris and Capillaria eggs were also detected. This study shows the risks to which the population is exposed in relation to zoonotic geohelminths, and suggests that sanitation and health education measures should be implemented in the municipality.A frequência de contaminação parasitária de áreas públicas de Pelotas, Rio Grande do Sul, Brasil, foi avaliada entre junho de 2010 e maio de 2011, com coletas mensais de amostras de solo de oito praças. Das 400 amostras submetidas à técnica de centrífugo-flutuação em solução de dicromato de sódio com densidade de 1,35, 176 (44% apresentaram pelo menos uma forma parasitária e, das amostras positivas, 29 (16,5% estavam poliparasitadas. Os resultados demonstraram relevante índice de contaminação do solo em todas as praças avaliadas, com maiores índices de positividade para ovos de ancilostomídeos (13,5% e ovos de Toxocara (8,8%, sendo também identificados ovos de Trichuris, Ascaris e Capillaria. O estudo demonstrou a contaminação ambiental de praças públicas e os riscos a que a população está exposta em relação a doenças causadas por geoparasitos zoonóticos e sugere que medidas de saneamento e educação em saúde devem ser implementadas no município.

  16. Espinheira-santa (Maytenus ilicifolia Mart. ex Reiss.: saber de erveiros e feirantes em Pelotas (RS

    C. ALMEIDA

    2015-01-01

    Full Text Available RESUMO O objetivo deste trabalho é descrever o conhecimento popular relacionado à espinheira-santa (Maytenus ilicifolia entre erveiros e feirantes que comercializam a planta no centro de Pelotas, Rio Grande do Sul, Brasil. Foi realizada uma pesquisa de abordagem qualitativa, exploratória e descritiva, de agosto a outubro de 2013. Entrevistas semi-estruturadas, com questões sobre os saberes e práticas relacionados à espinheira-santa, foram aplicadas a cinco erveiros e três feirantes do mercado informal de plantas medicinais. Para a análise dos dados foi utilizada a proposta operativa de Minayo, sendo Capra o referencial teórico para este estudo. Foi verificado que o saber relacionado ao uso da espinheira-santa é transmitido de geração a geração, embora existam outras fontes de conhecimento. As indicações do uso popular da espinheira-santa com finalidade terapêutica estão relacionadas a distúrbios gástricos, cicatrização e depuração do sangue. As diferentes formas dos sujeitos deste estudo interagirem com o ambiente, com sua família e em outras relações interpessoais resultam em diferentes saberes relacionados à espinheira-santa.

  17. Listeria spp. no processamento de lingüiça frescal em frigoríficos de Pelotas, RS, Brasil Listeria spp. in the processing of fresh sausages in slaughterhou ses from Pelotas, RS, Brazil

    Wladimir Padilha da Silva

    2004-06-01

    Full Text Available Alimentos intensamente manipulados, como as lingüiças mistas do tipo frescal são freqüentemente responsáveis pela veiculação de enfermidades transmitidas por alimentos. Devido ao risco à saúde pública que a bactéria Listeria monocytogenes representa, este trabalho teve como objetivo estudar a presença de Listeria spp., em especial de L. monocytogenes, durante o processamento de lingüiças mistas do tipo frescal, em três frigoríficos com inspeção sanitária estadual, em Pelotas-RS. Para isso, analisou-se a matéria-prima utilizada no preparo da lingüiça, os equipamentos da linha de processamento e o produto final. Isolou-se Listeria spp. em 100% das 41 amostras analisadas, nos 3 estabelecimentos estudados. Dentre as diferentes espécies, L. innocua foi aquela isolada com maior freqüência, em 97,6% das amostras, seguida por L. monocytogenes em 29,3% e L. welshimeri em 24,4%. A presença destes microrganismos nas amostras analisadas, em especial no produto final, demonstra a necessidade de readequação nas práticas de limpeza e sanificação das plantas de processamento analisadas, bem como representa risco potencial de listeriose ao consumidor.Food that is highly manipulated, such as fresh sausages, is frequently responsible for spreading food borne diseases. Due to the threat that the bacterium Listeria monocytogenes represents to public health, the aim of this work was to study the presence of Listeria spp., especially Listeria monocytogenes, during processing of fresh sausages, in three slaughterhouses with state food inspection, in the city of Pelotas, Brazil. The raw material used for the sausage elaboration, the equipment used in the processing and the end products were analyzed. The results showed Listeria spp. in 100% of the 41 samples analyzed. Among the different species, L. innocua was the most frequent, isolated from 97.6% of the samples, followed by the L. monocytogenes and L. welshimeri that were isolated from

  18. Biochronostratigraphy and paleoenvironment analysis of Neogene deposits from the Pelotas Basin (well 2-TG-96-RS), Southernmost Brazil.

    Silva, Wagner G; Zerfass, Geise S A; Souza, Paulo A; Helenes, Javier

    2015-09-01

    This paper presents the integration of micropaleontological (palynology and foraminifera) and isotopic (87Sr/86Sr) analysis of a selected interval from the well 2-TG-96-RS, drilled on the onshore portion of the Pelotas Basin, Rio Grande do Sul, Brazil. A total of eight samples of the section between 140.20 and 73.50 m in depth was selected for palynological analysis, revealing diversified and abundant palynomorph associations. Species of spores, pollen grains and dinoflagellate cysts are the most common palynomorphs found. Planktic and benthic calcareous foraminifera were recovered from the lowest two levels of the section (140.20 and 134.30 m). Based on the stratigraphic range of the species of dinoflagellate cysts and sporomorphs, a span age from Late Miocene to Early Pliocene is assigned. The relative age obtained from the 87Sr/86Sr ratio in shells of calcareous foraminifers indicates a Late Miocene (Messinian) correspondence, corroborating the biostratigraphic positioning performed with palynomorphs. Paleoenvironmental interpretations based on the quantitative distribution of organic components (palynomorphs, phytoclasts and amorphous organic matter) throughout the section and on foraminiferal associations indicate a shallow marine depositional environment for the section. Two palynologicals intervals were recognized based on palynofacies analysis, related to middle to outer shelf (140.20 to 128.90 m) and inner shelf (115.75 to 73.50 m) conditions. PMID:26312424

  19. Avaliação nutricional de adultos da coorte de nascimentos de 1982, Pelotas, RS Evaluación nutricional de adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Nutritional evaluation follow-up of the 1982 birth cohort, Pelotas, Southern Brazil

    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de desnutrição por déficit ou excesso de peso e sua associação com fatores demográficos e socioeconômicos. MÉTODOS: Estudo longitudinal de coorte de jovens nascidos em 1982 em Pelotas, RS. Em 2004-5 foram entrevistados 4.198 dos 5.914 indivíduos dessa coorte, que tiveram suas medidas de peso e estatura coletadas para cálculo do índice de massa corporal (IMC. Definiu-se baixo peso pelo valor de IMC inferior a 18,5 kg/m²; excesso de peso, pelo IMC entre 25 e 30kg/m²; e obesidade pelo IMC>30kg/m². Os efeitos de variáveis socioeconômicas (renda familiar e escolaridade, demográfica (cor da pele, peso ao nascer e amamentação sobre baixo peso, excesso de peso e obesidade foram analisados utilizando regressão de Poisson separadamente para homens e mulheres. RESULTADOS: As prevalências de baixo peso, obesidade e excesso de peso foram 6,0%, 8,2% e 28,9%, respectivamente. Na análise ajustada somente o peso ao nascer manteve-se associado com baixo peso em homens e mulheres. Homens pobres tiveram maior risco de baixo peso, mas ficaram protegidos da obesidade e do excesso de peso. Por outro lado, o risco de obesidade e excesso de peso foi maior entre as mulheres pobres. CONCLUSÕES: Os resultados reforçam a importância da determinação socioeconômica sobre o estado nutricional, chamando atenção como esses fatores agem de forma distinta em homens e mulheres de diferentes situações nutricionais, indicando atenção no que se refere a medidas específicas na prevenção, melhorando o acesso à informação sobre educação alimentar e nutricional para toda população.OBJETIVO: Estimar la prevalencia de desnutrición por déficit o exceso de peso y su asociación con factores demográficos y socioeconómicos. MÉTODOS: Estudio longitudinal de cohorte de jóvenes nacidos en 1982 en Pelotas (Sur de Brasil. En 2004-5 fueron entrevistados 4.198 de los 5.914 individuos de esa cohorte, que tuvieron sus

  20. RELATÓRIO DA INTERVENÇÃO DE RESTAURO DE UM LEQUE MANDARIM, ACERVO DO MUSEU MUNICIPAL PARQUE DA BARONESA, PELOTAS-RS

    Isabel Halfen Torino

    2013-02-01

    Full Text Available O presente relatório descreve as etapas de restauração de um leque chinês do século XIX, acervo do Museu Municipal Parque da Baronesa, localizado em Pelotas-RS. O trabalho observou as técnicas construtivas, a caracterização e o comportamento dos materiais constituintes da peça, concentrando-se na diversidade de matérias primas integradas neste objeto e suas interações no processo de restauro. A intenção deste estudo foi a de contribuir para a conservação e orientar para as práticas adequadas de recuperação de acervos desta tipologia para Pelotas e região.

  1. Elections and political changes in Brazil in the 80’s: an analysis from a sub-national unity (Pelotas, RS

    Alvaro Augusto de Borba Barreto

    2009-06-01

    Full Text Available It examines how the elections in the 1980s (General, in 82 and 86; local, 82 and 88; presidential, 89, reflected in the city of Pelotas (RS, with the aim to identify and close separations the behavior of voters in the national historical process. The prospect is that these four elections show a party system in the process of fragmentation and rules in transformation, which entailed significant changes in the behavior of voters and the actors chosen to lead the national and local policy.

  2. Prevalência e fatores associados à ocorrência de anemia entre menores de seis anos de idade em Pelotas, RS Prevalence of anemia and associated factors among children under six years of age in Pelotas, South Brazil

    Iná dos Santos; Juraci Almeida César; Gicele Minten; Neiva Valle; Nelson Arns Neumann; Eduardo Cercato

    2004-01-01

    OBJETIVOS: Determinar a prevalência e investigar fatores associados à ocorrência de anemia entre menores de seis anos de idade atendidos pela Pastoral da Criança em Pelotas, RS. MÉTODOS: Na fase de rastreamento de uma intervenção nutricional, as crianças foram avaliadas através de estudo transversal. No domicílio, após consentimento informado, a mãe foi entrevistada, sendo coletadas informações sobre características demográficas e socioeconômicas da família, saúde da criança, características ...

  3. TURISMO NO ESPAÇO RURAL, PRÁTICAS LOCAIS E IMIGRAÇÃO ITALIANA: O Caminho Colonial do Vinho, Pelotas/RS.

    Tiaraju Salini Duarte

    2011-11-01

    Full Text Available Resumo: As novas características e funções do espaço rural despertam interesse em diferentes áreas do conhecimento, a partir da década de 1980, devido às transformações que levaram a agricultura a se adaptar às novas exigências do mercado. A multifuncionalidade da agricultura é um fenômeno atual, presente no espaço rural, ou seja, as atividades agrícolas passam a não serem as únicas fontes geradoras de renda para o agricultor. Partindo dessas concepções, o turismo no espaço rural do município de Pelotas/RS, mais especificamente no Distrito do Rincão da Cruz, representa a possibilidade de valorização das paisagens naturais e da herança cultural da imigração italiana presentes no local. Para a população urbana, o espaço rural é lócus de lazer e, simultaneamente, depositário de um saber-fazer em relação aos produtos locais, como a uva e seu processamento. Palavras-chave: Turismo Rural. Imigração italiana. Vitivinicultura. Pelotas/RS

  4. Prevalência de consultas médicas e fatores associados, Pelotas (RS), 1999-2000 Prevalencia de consultas médicas y factores asociados en Pelotas (Sur de Brasil), 1999-2000 Prevalence of medical visits and associated factors, Pelotas, Southern Brazil, 1999-2000

    Juvenal Soares Dias da Costa; Mauri Caldeira Reis; Claudio Viana Silveira Filho; Rogério da Silva Linhares; Fábio Piccinini

    2008-01-01

    OBJETIVO: Estimar a prevalência de consultar com médico e analisar fatores a ela associados. MÉTODOS: Estudo transversal de base populacional realizado de dezembro de 1999 a abril de 2000, na cidade de Pelotas (RS). Foram incluídos 1.962 indivíduos de ambos os sexos, de 20 a 69 anos, residentes na zona urbana. Os dados foram coletados por meio de questionários padronizados e pré-codificados. O desfecho "consultar com médico nos 12 meses antes da entrevista" foi analisado com fatores socioecon...

  5. O periódico a palavra como possibilidade de estudo da Associação Católica de Professores (Pelotas/RS 1930-1940 - The periodical a palavra as a source to study the Catholic Association of Teachers (Pelotas/RS 1930-1940

    Adriana Duarte Leon, Brasil

    2011-07-01

    Full Text Available Este artigo tem como objetivo abordar aspectos sobre a existência da Associação Católica de Professores e Cultura Social, no município de Pelotas/RS, nas décadas de 1930 e 1940. Pela análise do periódico A palavra, busca-se tecer considerações sobre a existência, função e intervenção desta Associação no município. A periodização estabelecida está relacionada com o período auge de atuação da instituição. A análise das fontes leva a crer que a Associação surge com a função de propagar e defender os interesses da Igreja católica junto a instituições educacionais, principalmente junto às instituições públicas. O estudo desta instituição é profícuo, pois a mesma cumpriu papel significativo na história da profissão docente no município de Pelotas.Palavras-chave: Associação Católica de Professores, igreja católica, história, profissão docente. THE PERIODICAL A PALAVRA AS A SOURCE TO STUDY THE CATHOLIC ASSOCIATION OF TEACHERS (PELOTAS/RS 1930-1940AbstractThis article aims at discussing aspects of the Catholic Association of Teachers and Social Culture, in Pelotas city, Brazil, in the 1930's and 1940's. The roles and actions of this association are analyzed via the periodical A palavra. The period set to be studied is related with the most prestigious period of the association. The sources make us believe that the association is thought as an instrument to divulge and defend Catholic Church interests related to educational institutions. The study of this institution is very helpful to understand how catholics had significant influence on teacher profession in Pelotas.Key-words: Teachers Catholic Association, catholic church, teacher profession. EL PERIÓDICO A PALAVRA COMO POSSIBILIDAD DE ESTUDIO DE LA ASOCIACIÓN CATÓLICA DE PROFESORES (PELOTAS/RS 1930-1940ResumenEste artículo tiene como objetivo abordar aspectos sobre la existencia de la Asociación Católica de Profesores y Cultura Social, en el

  6. Prevalência de cardiopatias congênitas em portadores da síndrome de Down na cidade de Pelotas (RS Prevalence of congenital heart defects in patients with Down syndrome in the municipality of Pelotas, Brazil

    Luciana T. Vilas Boas

    2009-10-01

    Full Text Available OBJETIVO: Determinar a prevalência de cardiopatias congênitas em portadores da síndrome de Down na cidade de Pelotas (RS, descrevendo os tipos mais frequentes e avaliando os fatores associados. MÉTODOS: Estudo transversal que incluiu crianças portadoras de síndrome de Down nascidas e residentes em Pelotas no período de janeiro de 2000 a dezembro de 2005. Os dados foram obtidos através de entrevistas realizadas nos domicílios dos pacientes, com as mães ou seus familiares legais. Para o estudo dos fatores relacionados à presença de cardiopatia congênita, foram realizadas análises univariada e bivariada. RESULTADOS: Foram entrevistadas 47 mães de pacientes com síndrome de Down, sendo que 22 (46,8% pacientes apresentavam diagnóstico de cardiopatia congênita. Destes, 28% receberam avaliação cardiológica precoce, antes dos 3 meses de vida. A cardiopatia mais frequente foi a comunicação interatrial (17%; o defeito do septo atrioventricular ocorreu em cinco pacientes. A análise bivariada entre o desfecho presença de cardiopatia congênita e os fatores preditores idade materna, idade paterna, cor dos pais e da criança, presença de outras malformações e sexo da criança mostraram que as associações não foram estatisticamente significativas. CONCLUSÕES: As prevalências de síndrome de Down e de cardiopatia congênita em nossa região apresentam-se semelhantes às encontradas por outros autores, ressaltando-se a importância da suspeita diagnóstica e do encaminhamento precoce por parte dos pediatras para avaliação cardiológica. Destaca-se também o baixo número de pacientes que realizaram cariótipo. Além disso, o número de malformações associadas foi inferior ao encontrado por outros autores.OBJECTIVE: To determine the prevalence of congenital heart defects in patients with Down syndrome in the municipality of Pelotas, Brazil, describing the most frequent types and assessing the associated factors. METHODS: Cross

  7. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

    Santos, Iná S; Roberto Carlos Baroni; Ivanete Minotto; Ana Guerda Klumb

    2000-01-01

    OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximida...

  8. GESTÃO DE RESÍDUOS SÓLIDOS URBANOS: ESTUDO DO CASO DA RECICLAGEM EM PELOTAS, RS

    Godecke, Marcos Vinicius; Walerko, Vandressa Siqueira

    2015-01-01

    Diante das evidências relacionadas ao baixo índice de reaproveitamento dos materiais recicláveis no Brasil, este estudo toma o caso do município de Pelotas, região sul do estado do Rio Grande do Sul, para discutir programas que possam ser implementados para a ampliação da eficiência do serviço de coleta seletiva domiciliar de recicláveis. Além de referenciais bibliográficos e documentais, utiliza pesquisa de campo e entrevistas com os principais agentes envolvidos, incluindo técnicos municipa...

  9. "JÁ QUE A DESGRAÇA ASSIM QUERIA" UM FEITICEIRO FOI SACRIFICADO: CURANDEIRISMO, ETNICIDADE E HIERARQUIAS SOCIAIS (PELOTAS - RS, 1879

    Paulo Roberto Staudt Moreira

    2013-01-01

    Full Text Available On Wednesday, January 15, 1879, a slave born in the province of Pernambuco and who worked making salted meat in Pelotas, Rio Grande do Sul, stabbed to death a freed African (of the Mina nation who was renowned as a sorcerer and amulet maker. Court cases involving sorcerers provide windows into slave society in intimate detail. This article, based on an analysis of case studies, examines the relational field of possibilities in which captives lived, whether they were in prison or at work making salted meat. This kind of documentation also allows us to come closer to the market of beliefs and the role of sorcerers/ healers in sociability and in contouring ethnic and social identity.

  10. Risk factors for perinatal mortality in an urban area of Southern Brazil, 1993 Fatores de risco para mortalidade perinatal em Pelotas, RS, 1993

    Ana M. B. Menezes

    1998-06-01

    Full Text Available INTRODUCTION: Although there was a considerable reduction in infant mortality in Pelotas, Rio Grande do Sul in the last decade, its perinatal causes were reduced only by 28%. The associated factors of these causes were analised. MATERIAL AND METHOD: All hospital births and perinatal deaths were assessed by daily visits to all the maternity hospitals in the city, throughout 1993 and including the first week of 1994. RESULTS: The perinatal mortality rate was 22.1 per thousand births. The multivariate analysis showed the following risk factors: low socioeconomic level, male sex and maternal age above 35 years . Among multigravidae women, the fetal mortality rate was significantly increased for mothers with a previously low birthweight and a previous stillbirth. For early neonatal mortality the risk was significantly increased by a smaller number of antenatal visits than 5 and low birthweight. CONCLUSIONS: Main risk factors for perinatal mortality: low socioeconomic level, maternal age above 35 years and male sex. For early neonatal mortality the risk was significantly increased by a smaller number of antenatal visits than 5 and low birthweight.INTRODUÇÃO: Apesar de importante redução da mortalidade infantil em Pelotas, RS, na última década, as causas perinatais foram reduzidas em apenas 28%. Analisou-se os principais fatores associados a essas causas. MATERIAL E MÉTODO: Todos os nascimentos hospitalares e óbitos perinatais, em Pelotas, foram acompanhados através de visitas diárias aos hospitais, durante 1993 até a primeira semana de 1994. RESULTADOS: O coeficiente de mortalidade perinatal foi 22,1/1.000 nascimentos. A análise multivariada apontou os seguintes fatores de risco: baixo nível socioeconômico, sexo masculino e idade materna acima de 35 anos. Nas multíparas, encontrou-se maior risco para a mortalidade fetal naquelas que relatavam baixo peso prévio e natimorto prévio. A mortalidade neonatal precoce esteve associada com n

  11. Os jornais estudantis Ecos Gonzagueanos e Estudante: apontamentos sobre o ensino secundário católico e laico (Pelotas/RS, 1930 a 1960 - The student newspaper Ecos Gonzagueanos e Estudante: notes on the secondary schools catholic and secular (Pelotas/RS

    Giana Lange do Amaral, Brasil

    2013-04-01

    Full Text Available O presente texto trata do uso de jornais estudantis como fonte para estudos em História da Educação, bem como da importância da leitura de jornais escolares. Privilegia-se a análise de dois jornais de escolas de ensino secundário católico e laico de Pelotas/RS: o Ecos Gonzagueanos e o Estudante. Nas investigações que abordam as práticas culturais, seus sujeitos e sua produção, os jornais estudantis são considerados elementos potenciais para a apreensão das práticas, dos discursos e do cotidiano escolar. É possível observar valores, costumes e interesses que balizavam as relações dos jovens estudantes, bem como os reflexos das apropriações feitas a partir da cultura escolar da instituição a qual estavam ligados.Palavras-chave: jornais estudantis, fontes históricas, ensino secundário, ensino laico e católico. THE STUDENT NEWSPAPER ECOS GONZAGUEANOS E ESTUDANTE: NOTES ON THESECONDARY SCHOOLS CATHOLIC AND SECULAR (PELOTAS/RS, 1930 A 1960AbstractThis paper discusses the use of student newspapers as a source for studies in history of education, as well as the importance of reading school newspaper. Focuses on the analysis of two newspapers of catholic secondary schools and secular of Pelotas/RS: Ecos Gonzagueanos and Estudante. In investigations that address cultural practices, their subjects and their production, student newspapers are considered potential elements for the seizure of the practices, discourses and daily life at school. You can see the values, customs and interests that oriented the relationships of young students as well as the reflections of the appropriations made from the school culture of the institution to which they were connected.Key-words: student newspapers, historical sources, secondary education, secular and catholic education. LOS PERIÓDICOS ESTUDANTILES ECOS GONZAGUEANOS E ESTUDANTE: NOTAS SOBRE LAS ESCUELAS SECUNDARIAS CATÓLICAS E SECULARES (PELOTAS/RS, 1930 A 1960ResumenEste art

  12. Canine coronavirus (CCoV in dogs vaccinated and unvaccinated domiciliated in Pelotas, RS, Brazil Coronavirus canino (CCoV em cães vacinados e não vacinados domiciliados em Pelotas, RS

    Geferson Fischer

    2010-12-01

    Full Text Available Canine coronavirus (CCoV has been reported causing enteric disease mainly in young pups. In this study, to investigate immunity and exposure to CCoV, was estimated the frequency of serum antibodies to CCoV in 121 dogs in the Pelotas, South of Brazil, by serum neutralization test (SN: 22 had not been vaccinated, 69 had been vaccinated at least once, and 30 had unknown vaccination history. Antibodies were present in 47,8% (33/69 of the vaccinated dogs, in 45,5% (10/22 of the unvaccinated, and in 43,3% (13/30 of the dogs with unknown historical vaccination. There was no significant relationship between these antibodies and sex, age, habitat, and season of collection. The results proved the circulation of the CCoV among this dog population and indicated that the infection affects a significant group of animals. The large proportion of seronegative vaccinated dogs indicates failure of CCoV vaccine in inducing neutralizing antibodies, suggesting that immunizations to CCoV should be reevaluated. The authors indicate the need for further studies in order to evaluate the impact of the infection caused by CCoV, as well as to propose and evaluate preventive measures. Coronavírus canino (CCoV foi relatado como causa de doença entérica principalmente em cães jovens. Nesse estudo, para investigar imunidade e exposição ao CCoV, foi estimado a frequência de anticorpos em 121 cães de Pelotas, sul do Brasil, pelo teste de soro-neutralização (SN: 22 não haviam sido vacinados, 69 haviam sido vacinados com pelo menos uma dose, e 30 possuíam histórico de vacinação desconhecido. Foram detectados anticorpos em 47,8% (33/69 dos cães vacinados, em 45,5% (10/22 dos não vacinados, e em 43,3% (13/30 dos cães com histórico de vacinação desconhecido. Não houve associação significativa entre os anticorpos e sexo, idade, habitação e estação da coleta. Os resultados confirmam a circulação do CCoV entre essa população de cães e indicam que a infec

  13. Estudo longitudinal das crianças nascidas em 1982 em Pelotas, RS, Brasil: metodologia e resultados preliminares Study in length of children born in Pelotas, Rio Grande do Sul, Brazil, in 1982: metodology and preliminary results

    César Gomes Victora

    1985-02-01

    Full Text Available Tentou-se acompanhar a morbi-mortalidade e o crescimento de uma coorte de 6.011 crianças urbanas nascidas em 1982 nos hospitais de Pelotas, RS, através de visitas domiciliares aos 12 meses (para uma amostra de 30% das crianças e aos 20 meses (para toda a população. Estas crianças representaram mais de 99% de todos os nascimentos urbanos naquele ano. Foi possível localizar 81% das crianças aos 12 meses e 86% aos 20 meses, devido a uma mudança na estratégia de trabalho de campo. A metodologia empregada e as principais dificuldades encontradas são descritas e as características ao nascer das crianças localizadas no acompanhamento são comparadas com as características das crianças não localizadas. A potencialidade de uso dos dados coletados é exemplificada através de alguns resultados preliminares mostrando as associações entre o peso ao nascer, a renda familiar e o estado nutricional aos 12 meses. O estudo mostra que é possível acompanhar, com uma perda relativamente pequena, uma coorte de crianças com base populacional em uma cidade brasileira de tamanho médio.A cohort of 6,011 urban children born in 1982 in the hospitals of Pelotas, Rio Grande do Sul, was followed up so that their morbidity, mortality and growth could be assessed. These children accounted for over 99% of all births in the city. A 30% sample of the children were visited at home when approximately 12 months old, and the whole population was visited at about 20 months of age. It was possible to locate 81% of the children at 12 months. This proportion increased to 86% at 24 months, due to a change in the logistics of the field work which then included visiting all 69,000 households in the city to locate children whose families had moved within the urban area. The methodology and main difficulties encountered are discussed, and the characteristics at birth of children who were located at the first follow-up visit was compared to those of children lost to

  14. Prevalência e fatores associados à ocorrência de anemia entre menores de seis anos de idade em Pelotas, RS Prevalence of anemia and associated factors among children under six years of age in Pelotas, South Brazil

    Iná dos Santos

    2004-12-01

    Full Text Available OBJETIVOS: Determinar a prevalência e investigar fatores associados à ocorrência de anemia entre menores de seis anos de idade atendidos pela Pastoral da Criança em Pelotas, RS. MÉTODOS: Na fase de rastreamento de uma intervenção nutricional, as crianças foram avaliadas através de estudo transversal. No domicílio, após consentimento informado, a mãe foi entrevistada, sendo coletadas informações sobre características demográficas e socioeconômicas da família, saúde da criança, características ao nascer, amamentação e freqüência semanal de consumo de alimentos. As crianças foram pesadas e medidas. Foi coletada uma amostra de sangue capilar da polpa digital em microcuveta e a leitura da concentração de hemoglobina foi feita em fotômetro portátil (Hemocue. Considerou-se como tendo anemia quando a concentração de hemoglobina era inferior a 11 g/dl. Por se tratar de desfecho freqüente, a associação com as variáveis independentes foi analisada por regressão de Poisson. A análise obedeceu a modelo hierárquico previamente definido. RESULTADOS: Foram identificadas 362 crianças menores de seis anos, sendo a hemoglobina dosada em 304 (84,0% delas. A prevalência de anemia foi de 53,0% (IC95% 47,2% - 58,7%. Os fatores de risco foram a menor idade da criança, cor não branca, presença de família numerosa e classe social E (em comparação à D. A disponibilidade de água encanada dentro de casa e o maior peso ao nascer mostraram-se fatores protetores. CONCLUSÕES: os achados deste estudo mostram uma alta prevalência de anemia entre as crianças alvo da ação da Pastoral da Criança, bem como a presença de diversos fatores de risco e poucos fatores de proteção, o que mostra a necessidade de intervenções preventivas.OBJECTIVES: to determine the prevalence of and investigate factors associated with anemia among children under six years of age, assisted by the Pastoral da Criança in Pelotas, South Brazil. METHODS

  15. Prevalência de consultas médicas e fatores associados, Pelotas (RS, 1999-2000 Prevalencia de consultas médicas y factores asociados en Pelotas (Sur de Brasil, 1999-2000 Prevalence of medical visits and associated factors, Pelotas, Southern Brazil, 1999-2000

    Juvenal Soares Dias da Costa

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de consultar com médico e analisar fatores a ela associados. MÉTODOS: Estudo transversal de base populacional realizado de dezembro de 1999 a abril de 2000, na cidade de Pelotas (RS. Foram incluídos 1.962 indivíduos de ambos os sexos, de 20 a 69 anos, residentes na zona urbana. Os dados foram coletados por meio de questionários padronizados e pré-codificados. O desfecho "consultar com médico nos 12 meses antes da entrevista" foi analisado com fatores socioeconômicos, demográficos, presença de doenças crônicas e distúrbios psiquiátricos, estado nutricional, tabagismo, consumo de bebidas alcoólicas, e internação no ano anterior à entrevista. Foi realizada regressão de Poisson seguindo modelo hierarquizado, controlada por variáveis de confusão, considerando nível de significância OBJETIVO: Estimar la prevalencia de consultas con un médico y analizar factores asociados a ella. MÉTODOS: Se realizó estudio transversal de base poblacional de diciembre de 1999 a abril de 2000, en la ciudad de Pelotas (Sur de Brasil. Fueron incluidos 1.962 individuos de ambos sexos, de 20 a 69 años, residentes en la zona urbana. Los datos fueron colectados por medio de cuestionarios estandarizados y pre-codificados. La condición "consultar con médico en los 12 meses antes de la entrevista" fue analizada con factores socioeconómicos, demográficos, presencia de enfermedades crónicas y disturbios psiquiátricos, estado nutricional, tabaquismo, consumo de bebidas alcohólicas e internación en el año anterior a la entrevista. Fue realizada una regresión de Poisson siguiendo el modelo jerarquizado, controlado por variables de confusión, considerando nivel de significancia OBJECTIVE: To estimate the prevalence of visiting doctors and to analyze associated factors. METHODS: Cross-sectional, population-based study performed in the city of Pelotas, Southern Brazil, between December 1999 and April 2000. A total of

  16. Proposições Estratégicas a partir da Análise da Rede de Valor e do Capital Social: um estudo no Pólo de Doces de Pelotas-RS

    Jordana Marques Kneipp; Jamur Johnas Marchi; Clandia Maffini Gomes; Luciana Aparecida Barbieri da Rosa

    2013-01-01

    http://dx.doi.org/10.5007/2175-8077.2013v15n36p175 O presente artigo buscou apresentar proposições estratégicas para o Polo de Doces de Pelotas, localizado na Região Sul do Estado do Rio Grande do Sul – RS, a partir do mapeamento da rede de valor e da análise do capital social. O Polo de Doces reúne empresas formais e empreendedores informais ligados ao mercado de doces. A pesquisa caracteriza-se como quantitativa e os dados foram coletados por meio de questionários. Como resultado, percebeu-...

  17. Tabagismo na coorte de nascimentos de 1982: da adolescência à vida adulta, Pelotas, RS Tabaquismo en la cohorte de nacimientos de 1982: de la adolescencia a la vida adulta, Pelotas, Sur de Brasil Smoking prevalence in the 1982 birth cohort: from adolescence to adult life, Pelotas, Southern Brazil

    Ana M B Menezes

    2008-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de tabagismo em adolescentes e adultos jovens pertencentes a uma coorte de nascimentos de base populacional. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas, RS, entrevistados em 1997, 2000-1 e 2005. O desfecho estudado foi o tabagismo, definido como consumo de pelo menos um cigarro na última semana nos acompanhamentos de 1997 e 2000-1. No acompanhamento de 2005, a variável dependente foi tabagismo atual. A análise ajustada foi realizada por meio de regressão de Poisson. RESULTADOS: As prevalências de tabagismo entre homens foram de 5,9%, 20,2% e 27,6% nos acompanhamentos de 1997, 2000-1 e 2005, respectivamente. Os respectivos valores para as mulheres foram 9,3%, 27,5% e 23,6%. A idade média de início do fumo foi de 15,1 anos (dp=2,5. Na análise multivariável, menor escolaridade materna, baixa renda familiar em 1982, ter sido pobre durante todo o período acompanhado e fumo materno na gravidez estiveram significativamente associados com maiores prevalências de fumo em ambos os sexos. A cor da pele não branca associou-se com maior risco de fumo apenas entre as mulheres. A amamentação não mostrou associação com tabagismo. Nas mulheres, o fumo esteve inversamente associado com o peso ao nascer na análise bruta, mas perdeu a significância na ajustada. CONCLUSÕES: A maior concentração de tabagismo nos grupos mais pobres sugere que condutas como o combate ao fumo na gestação e o aumento do preço do cigarro poderiam ter importante impacto populacional.OBJETIVO: Evaluar la prevalencia de tabaquismo en adolescentes y adultos jóvenes pertenecientes a una cohorte de nacimientos de base poblacional. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas, RS, entrevistados en 1997, 2000-1 y 2005. El desenlace estudiado fue el tabaquismo, definido como consumo de al menos un cigarro en la última semana en los acompañamientos de 1997 y

  18. Monitorização da mortalidade na coorte de nascimentos de 1982 a 2006, Pelotas, RS Monitoreo de la mortalidad en la cohorte de nacimientos de 1982 a 2006, Pelotas, Sur de Brasil Monitoring mortality in Pelotas birth cohort from 1982 to 2006, Southern Brazil

    Bernardo L Horta

    2008-12-01

    Full Text Available OBJETIVO: Avaliar a mortalidade em uma coorte acompanhada desde o nascimento em 1982 até 2006 e examinar os fatores associados. MÉTODOS: Em 1982, todas as 5.914 crianças nascidas nos hospitais em Pelotas (RS foram identificadas e acompanhadas prospectivamente. Entre 1982 e 1987, a ocorrência de óbitos foi monitorada por meio de visitas regulares aos hospitais, cemitérios e serviço de registro de óbitos. A partir de 1987, os dados de óbitos foram obtidos somente do Sistema de Informações sobre Mortalidade . As variáveis estudadas foram: sexo, cor da pele materna, escolaridade materna, renda familiar, peso ao nascer, peso e estatura por idade. Foi utilizada a regressão de Poisson para estimar o risco relativo de mortalidade. RESULTADOS: Entre 1982 e 2006 foram identificados 288 óbitos. O coeficiente de mortalidade infantil foi de 36 óbitos/1.000 nascidos vivos; e nos grupos etários 1-4 anos, 5-14 anos e 15-24 anos foi de 14,4, 4,1 e 5,4 óbitos para cada 1.000 indivíduos vivos no início do período, respectivamente. Em todas as faixas etárias, a mortalidade foi maior entre indivíduos de renda familiar baixa, com risco relativo de 2,89 (IC 95%: 2,08; 4,03 na comparação entre o primeiro e o terceiro tercil, após controle para sexo e cor da pele. Baixo peso ao nascer e déficits de altura por idade e peso para altura aos dois anos de idade estiveram associados com maior risco de mortalidade até os 4 anos, mas não a partir desta idade. CONCLUSÕES: O efeito da iniqüidade social na infância persiste até o início da vida adulta, mas o peso ao nascer e o estado nutricional na infância não têm efeito duradouro sobre a mortalidade de adolescentes e adultos jovens.OBJETIVO: Evaluar la mortalidad en una cohorte acompañada desde el nacimiento en 1982 hasta 2006 y examinar los factores asociados. MÉTODOS: En 1982, todos los 5.914 niños nacidos en hospitales en Pelotas (Sur de Brasil fueron identificados y acompa

  19. O periódico A palavra como possibilidade de estudo da Associação Católica de Professores (Pelotas/RS 1930-1940

    Adriana Duarte Leon

    2011-07-01

    Full Text Available Este artigo tem como objetivo abordar aspectos sobre a existência da Associação Católica de Professores e Cultura Social, no município de Pelotas/RS, nas décadas de 1930 e 1940. Pela análise do periódico A palavra, busca-se tecer considerações sobre a existência, função e intervenção desta Associação no município. A periodização estabelecida está relacionada com o período auge de atuação da instituição. A análise das fontes leva a crer que a Associação surge com a função de propagar e defender os interesses da Igreja católica junto a instituições educacionais, principalmente junto às instituições públicas. O estudo desta instituição é profícuo, pois a mesma cumpriu papel significativo na história da profissão docente no município de Pelotas.

  20. Uso de medicamentos do nascimento aos dois anos: Coorte de Nascimentos de Pelotas, RS, 2004 Uso de medicamentos desde el nacimiento hasta los dos años: Cohorte de Nacimientos de Pelotas, Sur de Brasil, 2004 Medicine use from birth to age two years: the 2004 Pelotas (Brazil Birth Cohort Study

    Edilson Almeida de Oliveira

    2010-08-01

    Full Text Available OBJETIVO: Descrever a utilização de medicamentos em crianças aos três, 12 e 24 meses de idade. MÉTODOS: Estudo transversal utilizando dados da Coorte de Nascimentos de Pelotas, RS, de 2004. Foram incluídas 3.985 crianças aos três meses, 3.907 aos 12 meses e 3.868 aos 24 meses de idade. O desfecho considerado foi o uso de medicamentos pelas crianças nos 15 dias anteriores à entrevista. Informações sobre as variáveis independentes (medicamentos utilizados, fonte de indicação, forma de aquisição, regularidade do uso e grupos terapêuticos foram coletadas por meio de questionário padronizado, em entrevista aos pais nos domicílios. RESULTADOS: As prevalências de uso de medicamentos aos três, 12 e 24 meses foram de 65,0% (IC 95%: 63,5;66,5, 64,4% (IC 95%: 62,9;65,9 e 54,7% (IC 95%: 53,1;56,2, respectivamente. Com o avanço da idade observou-se diminuição no número total de medicamentos utilizados e aumento na automedicação, essa última chegando a 34% aos 24 meses. Também, a freqüência do uso de medicamentos em caráter eventual aumentou e diminuiu a de uso contínuo. Os medicamentos foram adquiridos principalmente com recursos próprios e cerca de 10% foi adquirido pelo Sistema Único de Saúde. Observou-se mudança no perfil dos grupos terapêuticos mais utilizados em função da idade. Aos três meses, o maior uso foi de medicamentos dermatológicos (36%; aos 12 meses, de medicamentos para o sistema respiratório (24%; e, aos 24 meses, de analgésicos (26%. Comparando-se o uso aos 24 meses com o dos três meses de idade observou-se diminuição na utilização de: medicamentos destinados ao trato alimentar e metabolismo, aos órgãos dos sentidos, sistema cardiovascular e produtos dermatológicos. Houve aumento na utilização de: medicamentos anti-infecciosos sistêmicos, destinados ao sistema musculoesquelético, ao sistema respiratório, analgésicos, antiparasitários, inseticidas e repelentes. CONCLUSÕES: A

  1. Prevalência de doação de sangue e fatores associados, Pelotas, RS Prevalencia de donación de sangre y factores asociados, Pelotas, Sur de Brasil Blood donation prevalence and associated factors in Pelotas, Southern Brazil

    Alethea Zago

    2010-02-01

    Full Text Available OBJETIVO: Estimar a prevalência de doação de sangue e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 2.986 indivíduos com 20 anos ou mais realizado em Pelotas, RS, em 2007. Foram considerados três desfechos: doação de sangue alguma vez na vida, doação no último ano e doação fidelizada (pelo menos duas doações no último ano. Cada desfecho foi analisado de acordo com variáveis demográficas, socioeconômicas, de saúde, exposição a campanhas de promoção da doação de sangue e ter parente ou amigo doador. A análise bruta e multivariável foi feita utilizando-se regressão de Poisson, com ajuste para o efeito do desenho amostral. RESULTADOS: As prevalências encontradas de doação de sangue alguma vez na vida, no último ano e de doação fidelizada, foram, respectivamente, 32%, 7,7% e 3,6%. Tais prevalências foram maiores para indivíduos do sexo masculino e aumentou conforme o nível econômico e a autopercepção da saúde. A prevalência de doação na vida foi maior para o grupo etário de 50 a 65 anos; no último ano, foi maior entre os mais jovens (20 a 29 anos; e a doação fidelizada foi maior para o grupo de 30 a 49 anos. Cor da pele, situação conjugal, religião, ter parente ou amigo doador e conhecimento sobre campanhas não apresentaram associação com nenhum dos desfechos analisados. CONCLUSÕES: A prevalência de doação de sangue foi maior para os homens e para aqueles com melhor auto-percepção de saúde e nível econômico. As campanhas de incentivo à doação deveriam diversificar o perfil dos doadores, de modo a atingir os grupos de pessoas menos propensas a doar sangueOBJETIVO: Estimar la prevalencia de donación de sangre y factores asociados. MÉTODOS: Estudio transversal con muestra representativa de 2.986 individuos con 20 años o más realizado en la ciudad de Pelotas, Sur de Brasil, en 2007. Fueron considerados tres hechos: donación de sangre alguna vez en la

  2. Prevalência de Diabetes Mellitus em Pelotas, RS: um estudo de base populacional Prevalence of Diabetes Mellitus in Southern Brazil: a population-based study

    Juvenal Soares Dias da Costa; Maria Teresa Anselmo Olinto; Maria Cecília Formoso Assunção; Denise Petrucci Gigante; Silvia Macedo; Ana Maria Baptista Menezes

    2006-01-01

    OBJETIVO: Comparar a prevalência de Diabetes Mellitus em população adulta, residente em área urbana, segundo auto-referência e valores de exame de glicemia de jejum. MÉTODOS: Realizou-se um estudo transversal de base populacional, com 1.968 pessoas de 20 a 69 anos, residentes na zona urbana da cidade de Pelotas, Estado do Rio Grande do Sul, em 2000. Estimou-se uma amostra de 1.800 indivíduos. Realizaram-se visitas domiciliares em 40 setores censitários sorteados aleatoriamente. Foi aplicado u...

  3. PROJETO DE SALVAMENTO ARQUEOLÓGICO DA ZONA URBANA DE PELOTAS/RS: CATÁLOGO DO MATERIAL ARQUEOFAUNÍSTICO DO SITIO CASA 8

    Chimene Kuhn Nobre

    2012-10-01

    Full Text Available O presente projeto de pesquisa teve como objetivo estudar os vestígiosarqueofaunísticos revelados pelas escavações realizadas em uma residênciapelotense do séc. XIX. A pesquisa insere-se em um projeto mais amplo,desenvolvido sob responsabilidade do Laboratório de Ensino e Pesquisa emAntropologia e Arqueologia (LEPAARQ/ICH/UFPEL, em parceria com aSecretaria Municipal de Cultura de Pelotas (SECULT, no âmbito do ProgramaBID/Monumenta.12 Trata-se de um projeto de salvamento arqueológico das Casas 2,6 e 8, Casa da Banha e Praça Coronel Pedro Osório, autorizado pela portariaIPHAN No 165, de 2 de Agosto de 2002. Conta com o apoio do CNPQ eFAPERGS.

  4. Exame citopatológico de colo uterino em mulheres com idade entre 20 e 59 anos em Pelotas, RS: prevalência, foco e fatores associados à sua não realização Pap smears of 20 - 59 year-old women in Pelotas, Southern Brazil: prevalence, approach and factors associated with not undergoing the test

    Arnildo A. Hackenhaar

    2006-03-01

    Full Text Available OBJETIVO: Determinar a prevalência e o foco de realização do exame citopatológico do colo uterino e também fatores associados à sua não realização em mulheres com idade entre 20 e 59 anos residentes na cidade de Pelotas, RS. MÉTODOS: Entre outubro e dezembro de 2003 foi realizado um estudo transversal de base populacional. Através de amostragem por conglomerados foram sorteados 144 setores censitários em múltiplos estágios. Foram investigadas variáveis sociodemográficas e a realização de exame citopatológico do colo uterino. RESULTADOS: Dentre as 1404 mulheres que constituem a população-alvo dos programas de prevenção do câncer do colo uterino, 83,0% realizaram o exame citopatológico do colo uterino nos três anos antecedentes a este estudo. Mostraram-se significativamente associadas (POBJECTIVE: This study aims to determine the prevalence of and approach of Pap smear tests, as well as associated factors in women living in Pelotas, RS, Southern Brazil, within the 20 - 59 age range, who did not undergo a Pap smear. METHODS: A cross-sectional population-based study was carried out from October to December 2003. 144 census tracts were sampled through a multiple-stage clustered method. Socio-demographic variables were investigated, as well as women's Pap smear tests. RESULTS: Among the 1,404 women who were the target population included in the early detection program of uterine cervix cancer, 83% had had Pap smears in the three years before the study. Variables statistically associated (p<0.05 with women not undergoing the test in the previous three years were: ages ranging from 20-29 to 50-59 years compared with 40-49 year-old women, lower schooling level, lower social level, mixed and black skin color, not having seen a gynecologist in the previous 12 months. CONCLUSIONS: Although this study presents a high coverage of women undergoing Pap smears, women that present higher risk factors for this type of cancer had fewer

  5. Qualidade da dieta de jovens aos 18 anos de idade, pertencentes à coorte de nascimentos de 1993 da cidade de Pelotas (RS, Brasil

    Cristina Bossle de Castilhos

    2015-11-01

    Full Text Available O objetivo deste artigo é descrever a qualidade da dieta de adolescentes segundo fatores sociodemográficos e comportamentais. Estudo transversal com 3.959 adolescentes de dezoito anos de idade, pertencentes à coorte de nascimentos de 1993, de Pelotas, Rio Grande do Sul, Brasil. O consumo alimentar foi avaliado através de um Questionário de Frequência Alimentar semiquantitativo, com período recordatório de 12 meses. A qualidade da dieta foi avaliada através do Índice de Qualidade da Dieta Revisado (IQD-R. Este índice varia de 0 a 100 pontos e quanto maior a pontuação, melhor a qualidade da dieta. A média geral do escore do IQD-R foi de 62,4 pontos (DP 12. Adolescentes com cor da pele não branca (63,1, provenientes de familias cujos chefes tinham menor escolaridade (63,6 e pertencentes ao menor quintil do índice de bens (64,7 apresentaram maiores médias no escore do IQD-R. Menores médias foram encontradas entre adolescentes que fumavam (58,5 e que consumiam bebida alcoólica (56,0. Este estudo mostrou que a qualidade da dieta dos adolescentes avaliados merece atenção, especialmente no que se refere à ingestão de vegetais, leites e derivados.

  6. Prevalência de Diabetes Mellitus em Pelotas, RS: um estudo de base populacional Prevalence of Diabetes Mellitus in Southern Brazil: a population-based study

    Juvenal Soares Dias da Costa

    2006-06-01

    Full Text Available OBJETIVO: Comparar a prevalência de Diabetes Mellitus em população adulta, residente em área urbana, segundo auto-referência e valores de exame de glicemia de jejum. MÉTODOS: Realizou-se um estudo transversal de base populacional, com 1.968 pessoas de 20 a 69 anos, residentes na zona urbana da cidade de Pelotas, Estado do Rio Grande do Sul, em 2000. Estimou-se uma amostra de 1.800 indivíduos. Realizaram-se visitas domiciliares em 40 setores censitários sorteados aleatoriamente. Foi aplicado um questionário padronizado a todos participantes da pesquisa, incluindo perguntas sobre a presença de "açúcar no sangue", e quando afirmativo, se algum médico havia confirmado a doença. Uma subamostra de 367 participantes foi sorteada para realização de exames, entre os quais glicemia de jejum. Adotou-se como ponto de corte da glicemia de jejum para reconhecimento de diabetes 126 mg/dl e 140 mg/dl. Os resultados foram apresentados na forma de freqüência e respectivos intervalos de confiança de 95%. RESULTADOS: Dos entrevistados, 110 (5,6%; IC 95%: 4,6-6,6 referiram a presença de Diabetes Mellitus com diagnóstico confirmado pelo médico. Para as 367 pessoas submetidas aos exames laboratoriais, a prevalência de diabetes auto-referido e confirmada por médico foi de 7,1% (IC 95%: 4,5-9,7. CONCLUSÕES: As estimativas de prevalência encontradas são compatíveis com as obtidas em outras investigações nacionais. Os estudos epidemiológicos de base populacional são raros no Brasil e podem contribuir para o planejamento em saúde.OBJECTIVE: To compare the prevalence of Diabetes Mellitus among the adult population of an urban area, according to self-reported diabetes and fasting glucose test results. METHODS: We carried out a population-based cross-sectional study of 1,968 subjects aged 20-69 years, living in the urban area of the city of Pelotas, Southern Brazil, in the year 2000. Sample size was calculated at 1,800 subjects. We visited the

  7. Produção e qualidade do leite na bacia leiteira de Pelotas-RS em diferentes meses do ano

    Martins Paulo Ricardo Garcia

    2006-01-01

    Full Text Available Avaliou-se a variação da produção e qualidade do leite, durante 11 meses do ano através do monitoramento de nove unidades produtoras de leite (UP, escolhidas aleatoriamente por pertencerem à bacia leiteira de Pelotas. Foram realizadas coletas mensais de leite e dos alimentos de cada UP. Foram avaliadas as características físico-químicas e contagem de células somáticas do leite, além da incidência de mastite e a produção média de leite das UP. As UP foram classificadas nos seguintes sistemas de produção: especializadas, semi-especializadas e não especializadas conforme critérios previamente estabelecidos. Na análise da variância, foram considerados os efeitos de sistemas de produção, meses do ano e a interação entre sistemas e meses do ano, segundo um delineamento completamente casualizado em arranjo fatorial. Foram observadas diferenças no leite produzido nos diversos meses do ano, quanto à produção de leite corrigida, proteína bruta, teor de caseína, teor de lactose, extrato seco total, extrato seco desengordurado e incidência de mastite, não sendo observadas, neste estudo, diferenças quanto às percentagens de gordura e nitrogênio não protéico do leite nem contagem de células somáticas. Nos meses de outono e inverno, ocorreram as menores produções de leite e menores teores dos componentes químicos, enquanto a ocorrência de mastite foi mais importante nos meses de primavera - verão.

  8. Nutrição materna e duração da amamentação em uma coorte de nascimento de Pelotas, RS

    Gigante Denise Petrucci

    2000-01-01

    Full Text Available OBJETIVO: Os efeitos da situação nutricional materna sobre a duração da amamentação são inconsistentes na literatura. O estudo realizado objetivou investigar esses efeitos em uma coorte de nascimentos hospitalares. MÉTODOS: Foram estudadas 977 mulheres que tiveram filhos no ano de 1993, em Pelotas (representando 20% dos nascimentos ocorridos nesse ano. Os efeitos da situação nutricional materna e de variáveis socioeconômicas e demográficas sobre a prevalência de amamentação aos seis meses de idade e sobre a duração da amamentação foram analisados pela regressão logística e de Cox, respectivamente. RESULTADOS: A análise multivariada mostrou que a prevalência de amamentação foi mais alta entre mulheres que iniciaram a gestação com 49 kg ou mais (RO = 1,31; IC95% 1,04 - 1,64, e a associação com altura materna foi no limiar da significância (p=0,06. A regressão de Cox mostrou um efeito protetor, no limiar da significância, do maior peso pré-gestacional sobre o desmame (RR = 0,91; IC95% 0,82 -- 1,01. Não houve diferença na duração da amamentação quanto à altura materna. O ganho de peso gestacional não mostrou associação com prevalência ou duração da amamentação. Idade materna, paridade, hábito de tabagismo e idade gestacional estiveram associadas significativamente com a amamentação em ambas as análises. Renda familiar mostrou associação com a prevalência de amamentação aos seis meses e o peso ao nascer com a duração da amamentação. CONCLUSÕES: Peso pré-gestacional foi um melhor preditor para duração da amamentação do que o ganho de peso gestacional.

  9. Produção integrada de pêssegos: três anos de experiência na região de Pelotas - RS Integrated production of peaches: 3 years of experience in the area of Pelotas, Rio Grande do Sul state, Brasil

    José Carlos Fachinello

    2003-08-01

    Full Text Available O objetivo do trabalho foi avaliar agronomicamente o sistema de produção integrada (PI x produção convencional (PC em pomar de pessegueiro cv. Diamante, no município de Pelotas - RS, comparando-se dados de três anos de avaliação (1999 - 2001, em duas áreas distintas. Os sistemas de produção caracterizaram-se: PC no qual prevalece o manejo e práticas culturais utilizadas normalmente pelo produtor e PI no qual são utilizadas as práticas de manejo definidas nas "Normas para Produção Integrada de Pêssego". As avaliações compreenderam: produção total, classificação dos frutos, danos, análises pós-colheita e resíduos de agrotóxicos. Pela análise da produção por planta e número de frutas produzidas por planta, pode-se verificar que a produção foi maior na PI. Pela avaliação da qualidade das frutas, verificou-se que houve aumento no número de frutas na categoria I, no sistema PI. A ocorrência de danos na colheita por insetos, doenças, pássaros e, muitas vezes, pela interação destes foi maior no sistema PC. Pela análise de agrotóxicos na polpa das frutas, não foram encontrados resíduos nas mesmas, dentro dos limites máximos estabelecidos. As frutas do sistema PI apresentaram, na colheita, maiores firmeza da polpa e teor de acidez, e menor teor de sólidos solúveis totais.The objective of this work was to evaluate agronomically the system of integrated production (IP x conventional production (CP in orchard of peach tree cv. Diamante in the rural area of Pelotas, Rio Grande do Sul State, Brazil. The study was conducted during three years (1999- 2001, in two different areas. The production systems were characterized as: in the CP prevails the handling and cultural practices usually used by the producer and IP is where the defined handling practices are used in the "Norms for Integrated Peach Production". The evaluations were: total production, classification of the fruits, damages, analyses post-harvesting and

  10. Explorando as múltiplas trajetórias de causalidade: colaboração entre antropologia e epidemiologia na coorte de nascimentos de 1982, Pelotas, RS Explorando las múltiples trayectorias de causalidad: colaboración entre antropología y epidemiología en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Exploring multiple trajectories of causality: collaboration between Anthropology and Epidemiology in the 1982 birth cohort, Pelotas, Southern Brazil

    Dominique P Béhague

    2008-12-01

    Full Text Available OBJETIVO: Embora a relação entre Epidemiologia e Antropologia tenha uma longa história, geralmente, ela tem sido compreendida por meio da integração dos métodos quantitativos e qualitativos em pesquisa. Recentemente, esses dois campos têm convergido para linhas conceituais e teóricas, enfatizando mais a explicação do que a simples descrição dos fenômenos investigados. O objetivo do estudo foi mostrar como a análise de dados etnográficos auxilia na interpretação aprofundada e teórica de dados epidemiológicos. MÉTODOS: As análises antropológicas do artigo foram obtidas usando métodos etnográficos, de 1997 a 2007, de uma amostra pertencente ao estudo de coorte de nascimento de 1982 em Pelotas (RS. As análises etnográficas foram estruturadas de acordo com os resultados de dois artigos epidemiológicos sobre os determinantes de morbidade mental e da idade de iniciação sexual. RESULTADOS E CONCLUSÕES: As análises etnográficas indicam diversos caminhos de influência e causalidade presentes nas associações estatísticas e que correspondem a experiências únicas de grupos específicos. Explorando esses caminhos, observaram-se vários fatores importantes que ajudam a explicar os resultados epidemiológicos, incluindo as respostas dos jovens às experiências de injustiça/desigualdade, o papel da violência na vida diária, os eventos de vida traumáticos, a reclusão social e introversão como resposta as dificuldades vividas, assim como a maturação psicossocial. A colaboração teórica e metodológica entre antropologia e epidemiologia é importante para a saúde pública, pois tem modificado positivamente esses dois campos do saber.OBJETIVO: A pesar de que la relación entre Epidemiología y Antropología tiene una larga historia, generalmente, ella ha sido comprendida por medio de la integración de los métodos cuantitativos y cualitativos en investigación. Recientemente, esos dos campos han convergido en l

  11. Percepção de exposição a cargas de trabalho e riscos de acidentes em Pelotas, RS (Brasil Workers' perception of exposure to occupational hazards and the risk of accidents in a Southern Brazilian city

    Rosângela C. Lima

    1999-04-01

    Full Text Available OBJETIVO: Investigar a associação entre a percepção de exposição às cargas de trabalho e o risco de acidentes. MÉTODOS: O delineamento do estudo foi o tipo de casos e controles. Os casos (n=264 incluíram os acidentes de trabalho típicos notificados no Instituto Nacional de Seguridade Social, de Pelotas, RS (Brasil, de janeiro a julho de 1996. Foram excluídos os óbitos (dois, os acidentes ocorridos na zona rural, e os que afastaram o trabalhador de suas atividades por menos de sete dias. Para cada caso foram selecionados três tipos de controles: um trabalhador da mesma empresa, um vizinho e um controle populacional. Os controles foram emparelhados com os casos por idade e sexo e precisavam ter vínculo empregatício formal e não ter sofrido acidente no último mês. Os dados foram analisados usando regressão logística condicional. RESULTADOS E CONCLUSÕES: Os trabalhadores que relatavam enfrentar situações de emergência, o trabalho em altura, perigo constante, ou ambientes ruidosos tinham cerca de duas vezes mais risco de acidentar-se. O trabalho em posições incômodas ou com esforço físico intenso aumentaram em 50% o risco de acidentes. As demais cargas de trabalho estudadas não se constituíram como fatores de risco para os acidentes. Os resultados foram ajustados para fatores de confusão.OBJETIVE: The study of the association between workers' perceptions of occupational hazards and the risk of occupational accidents. DESIGN: Case control study. POPULATION: The cases were 264 workers who presented a "typical" occupational accident, registered at the National Institute of Social Security in the city of Pelotas, between January and July, 1996. Fatal accidents (two were excluded, as were those leading to an absence of less than seven days from work. The cases were interviewed in their homes with a standard questionnaire. For each case, three controls were chosen: a fellow-work, a neighbor and a population control. Controls

  12. Condições de trabalho e automedicação em profissionais da rede básica de saúde da zona urbana de Pelotas, RS Working conditions and self-medication among primary healthcare professionals in an urban area of Pelotas, RS

    Elaine Tomasi

    2007-03-01

    Full Text Available Este estudo transversal investigou condições de trabalho e a morbidade dos profissionais de saúde da atenção básica em Pelotas, através de informações sociodemográficas, comportamentais, da atividade e ambiente de trabalho e de morbidade. Foram estudados 329 profissionais em 39 serviços. A grande maioria era do sexo feminino (80% e a média de idade era de 41 anos (±9,2 anos. Quase 30% dos profissionais pertenciam às classes C e D. O hábito de fumar foi referido por 19% dos indivíduos da amostra e 61% não praticaram nenhuma atividade física regular no mês anterior à entrevista. Cerca de metade dos entrevistados tinha outro emprego (51% e 25% precisaram faltar ao trabalho no último mês, principalmente por problemas pessoais de saúde (59% e problemas familiares (22%. Em média, os trabalhadores atendiam cerca de 30 pessoas por dia em uma jornada semanal de 40 horas. Problemas de saúde foram referidos por 40% dos entrevistados, com destaque para problemas do aparelho circulatório (27% e osteomusculares (18%. Independente de ter problema de saúde, 67% dos entrevistados faziam uso de medicamentos regularmente e 47% referiram este uso nos últimos 15 dias. Um quarto costumava automedicar-se, significativamente em maior proporção entre médicos e outros profissionais de nível superior, entre os trabalhadores de maior nível socioeconômico e entre aqueles com mais de um emprego.This cross-sectional study investigated working conditions and the morbidity of basic healthcare professionals in Pelotas using data on sociodemographics, behavior, activities and working environment, as well as morbidity. 329 professionals from 39 healthcare services were studied. The vast majority of these were women (80% and the average age was 41 (±9.2 years. Almost 30% of these professionals came from the C and D social strata; 19% were smokers and 61% had not done any regular physical exercise during the one month prior to being interviewed

  13. Abastecendo plantations: A inserção do charque fabricado em Pelotas (RS no comércio atlântico das carnes e a sua concorrência com os produtores platinos (século XIX

    Jonas Moreira VARGAS

    2014-12-01

    Full Text Available O charque (carne-seca constituiu alimento fundamental na dieta dos escravos das plantations açucareiras e cafeeiras e das populações pobres das cidades litorâneas do Brasil. O artigo analisa a inserção do charque fabricado em Pelotas (Rio Grande do Sul no mercado atlântico, assim como a concorrência com os produtores uruguaios e argentinos e como as guerras travadas na região da fronteira sul afetaram o comércio da mercadoria. Durante a segunda metade do século XIX, a carne-seca rio-grandense foi perdendo espaço no comércio atlântico para o produto platino, mais saboroso e de preço mais acessível. Na busca de novos mercados consumidores para além do Brasil e de Cuba, tanto os rio-grandenses quanto os produtores do Rio da Prata não conseguiram penetrar no mercado britânico, em que o paladar era mais exigente e se associava o charque à comida de escravos. Com o tempo, os argentinos conseguiram modernizar sua indústria com remessa de carne congelada para a Europa, ao passo que os rio-grandenses sucumbiram diante dessa nova concorrência e das exigências dos consumidores, não resistindo à derradeira crise que afetou o setor na década de 1880.

  14. Ronco habitual e apnéia obstrutiva observada em adultos: estudo de base populacional, Pelotas, RS Habitual snoring and obstructive sleep apnea in adults: population-based study in Southern Brazil

    Ricardo B Noal

    2008-04-01

    Full Text Available OBJETIVO: Estimar a prevalência de ronco habitual e apnéia obstrutiva observada e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 3.136 adultos, com 20 anos ou mais, residentes em Pelotas, Rio Grande do Sul, em 2005. Informações sobre os desfechos e variáveis demográficas, socioeconômicas, comportamentais e antropométricas foram coletadas por meio de questionário. A análise estatística bruta e ajustada foi realizada utilizando-se teste exato de Fisher ou qui-quadrado de tendência linear e regressão de Poisson, respectivamente. RESULTADOS: A prevalência encontrada de ronco habitual foi de 50,5% (IC 95%: 48,1;52,8 e de apnéia obstrutiva de 9,9% (IC 95%: 8,7;11,2. Na análise ajustada, o relato de ronco foi maior nos homens (Razão de Prevalências - RP=1,25; IC 95%: 1,16;1,34, nos idosos (RP=1,62; IC 95%: 1,46;1,80, nos tabagistas (RP=1,15; IC 95%: 1,07;1,25, nos alcoolistas (RP=1,17; IC 95%: 1,03;1,31 e nos obesos (RP 1,71, IC95% 1,55;1,88. O relato de apnéia obstrutiva foi maior nos homens (RP=2,05; IC 95%: 1,67;2,52, nos idosos (RP=2,23; IC 95%: 1,64;3,03, nos tabagistas (RP=1,60; IC 95%: 1,25;2,05 e nos obesos (RP=2,61; IC 95%: 1,97;3,47. CONCLUSÕES: Ronco habitual e apnéia obstrutiva foram sintomas comuns na população estudada. Fatores de risco conhecidos como sexo masculino e idade entre quarta e quinta décadas de vida não são modificáveis. Entretanto, tabagismo, alcoolismo e obesidade também associados aos desfechos, devem ser identificados e tratados na população geral.OBJECTIVE: To estimate the prevalence of habitual snoring and obstructive sleep apnea and their factors associated. METHODS: Cross-sectional study with a representative sample comprising 3,136 adults (>20 years living in the city of Pelotas, Southern Brazil, in 2005. A questionnaire was used to collect information on demographic, socioeconomic, behavioral and anthropometric variables and outcomes. Crude and adjusted

  15. Alimentação nos primeiros três meses de vida dos bebês de uma coorte na cidade de Pelotas, Rio Grande do Sul Alimentación en los primeros tres meses de vida de los bebés de una coorte en la ciudad de Pelotas, Rio Grande do Sul (Brasil) Feeding during the first three months of life for infants of a cohort in Pelotas, Rio Grande do Sul, Brazil

    Cristina Corrêa Kaufmann; Elaine Pinto Albernaz; Regina Bosenbecker da Silveira; Miriam Barcellos da Silva; Maria Laura W. Mascarenhas

    2012-01-01

    OBJETIVO: Estudar o padrão alimentar nos primeiros três meses de vida de crianças nascidas na cidade de Pelotas (RS). MÉTODOS: Estudo de coorte prospectivo com os bebês nascidos entre setembro de 2002 e maio de 2003, na cidade de Pelotas (RS). Incluíram-se 2.741 bebês nas maternidades e uma amostra aleatória de 30% acompanhada no primeiro e terceiro meses de vida. Foram realizadas análises uni, bi e multivariada. Somente as variáveis com p

  16. Hábitos alimentares de escolares adolescentes de Pelotas, Brasil Food habits of adolescent students from Pelotas, Brazil

    Marilda Borges Neutzling

    2010-06-01

    Full Text Available OBJETIVO: Descrever a frequência com que escolares adolescentes de Pelotas (RS estão seguindo as recomendações nacionais para uma alimentação saudável. MÉTODOS: Estudo transversal aninhado a um estudo longitudinal em 2004, incluindo adolescentes de 13 e 14 anos matriculados em 32 escolas públicas de Pelotas (RS. A amostra incluiu 2.209 adolescentes. Para avaliação da frequência de consumo alimentar, foi utilizado questionário proposto pelo Instituto Nacional do Câncer. Foram construídos desfechos baseados nos dez passos para a alimentação saudável propostos pelo Ministério da Saúde do Brasil. RESULTADOS: Os hábitos alimentares saudáveis mais frequentes foram o consumo diário de feijão e leite, relatado por cerca de metade dos adolescentes. Quase metade dos jovens referiu ingerir batata frita e salgadinhos no máximo uma vez por semana. Verificou-se consumo adequado de alimentos conservados e enlatados em 44,6% dos adolescentes. Pouco menos da metade dos jovens (43,6% nunca colocava sal adicional na comida. Quanto ao consumo de doces e outros alimentos ricos em açúcar, constatou-se que aproximadamente um terço deles consumia bolos ou biscoitos no máximo duas vezes por semana. CONCLUSÃO: Verificou-se baixa frequência de hábitos alimentares saudáveis em todos os subgrupos estudados, sendo a frequência mais baixa entre jovens de maior nível socioeconômico e entre as meninas. O hábito alimentar que apresentou mais baixa frequência - 5,3% dos adolescentes - foi o consumo de frutas e verduras cinco ou mais vezes por dia. Políticas públicas de promoção da saúde voltadas à melhoria da alimentação e nutrição dos adolescentes são necessárias e urgentes.OBJECTIVE: This study aimed to describe the extent to which adolescent students living in Pelotas, Brazil, follow the national recommendations for healthy eating. METHODS: A cross-sectional study was undertaken in 2004, nested to a longitudinal project

  17. Strontium isotope stratigraphy of the Pelotas Basin

    Strontium isotope data were obtained from foraminifera shells of the Pelotas Basin Tertiary deposits to facilitate the refinement of the chronostratigraphic framework of this section. This represents the first approach to the acquisition of numerical ages for these strata. Strontium isotope stratigraphy allowed the identification of eight depositional hiatuses in the Eocene-Pliocene section, here classified as disconformities and a condensed section. The reconnaissance of depositional gaps based on confident age assignments represents an important advance considering the remarkably low chronostratigraphic resolution in the Cenozoic section of the Pelotas Basin. The recognition of hiatuses that match hiatuses is based on biostratigraphic data, as well as on global events. Furthermore, a substantial increase in the sedimentation rate of the upper Miocene section was identified. Paleotemperature and productivity trends were identified based on oxygen and carbon isotope data from the Oligocene-Miocene section, which are coherent with worldwide events, indicating the environmental conditions during sedimentation. (author)

  18. Strontium isotope stratigraphy of the Pelotas Basin

    Zerfass, Geise de Santana dos Anjos, E-mail: geise.zerfass@petrobras.com.br [Petroleo Brasileiro S.A. (PETROBRAS/CENPES/PDGEO/BPA), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas e Desenvolvimento Leopoldo Americo Miguez de Mello; Chemale Junior, Farid, E-mail: fchemale@unb.br [Universidade de Brasilia (UnB), DF (Brazil). Instituto de Geociencias; Moura, Candido Augusto Veloso, E-mail: candido@ufpa.br [Universidade Federal do Para (UFPA), Belem, PA (Brazil). Centro de Geociencias. Dept. de Geoquimica e Petrologia; Costa, Karen Badaraco, E-mail: karen.costa@usp.br [Instituto Oceanografico, Sao Paulo, SP (Brazil); Kawashita, Koji, E-mail: koji@usp.br [Unversidade de Sao Paulo (USP), SP (Brazil). Centro de Pesquisas Geocronologicas

    2014-07-01

    Strontium isotope data were obtained from foraminifera shells of the Pelotas Basin Tertiary deposits to facilitate the refinement of the chronostratigraphic framework of this section. This represents the first approach to the acquisition of numerical ages for these strata. Strontium isotope stratigraphy allowed the identification of eight depositional hiatuses in the Eocene-Pliocene section, here classified as disconformities and a condensed section. The reconnaissance of depositional gaps based on confident age assignments represents an important advance considering the remarkably low chronostratigraphic resolution in the Cenozoic section of the Pelotas Basin. The recognition of hiatuses that match hiatuses is based on biostratigraphic data, as well as on global events. Furthermore, a substantial increase in the sedimentation rate of the upper Miocene section was identified. Paleotemperature and productivity trends were identified based on oxygen and carbon isotope data from the Oligocene-Miocene section, which are coherent with worldwide events, indicating the environmental conditions during sedimentation. (author)

  19. Demo 16. Colisión pelota de baloncesto-pelota de tenis

    Ferrer Roca, Chantal; Coll Company, César

    2013-01-01

    Objetivo: La pelota de tenis rebota hasta una altura superior a aquella desde la que fue lanzada cuando lo hace rebotando sobre la de baloncesto (no así cuando rebota en el suelo). Este fenómeno se explica apelando a la conservación de momento y energía mecánica.

  20. Prevalência de nascimentos gemelares em Pelotas, Rio Grande do Sul, Brasil Prevalence of twin births in Pelotas, in the State of Rio Grande do Sul, Brazil

    Cesar Fernando Geraldo

    2008-12-01

    Full Text Available OBJETIVOS: avaliar a prevalência de nascimentos gemelares em Pelotas, RS, em três períodos da última década e a influência de alguns fatores sobre este processo. MÉTODOS: estudo de corte transversal (série temporal, baseado no banco de dados do Programa de Monitorização de Defeitos Congênitos, onde se encontram registrados todos os nascimentos ocorridos nos cinco hospitais da cidade de Pelotas, nos anos de 1993, 1997 e 2003. RESULTADOS: a taxa média de gêmeos por mil nascimentos foi de 8,95‰ (monozigóticos=2,20‰ e dizigóticos=6,76‰ . A taxa de triplos ficou em 0,07‰ . A taxa total de nascimentos gemelares, assim como de gêmeos monozigóticos e dizigóticos sofreu elevação no período. A média de idade (27,53 anos e da ordem gestacional (2,35 das mães de gêmeos foi significativamente mais elevada do que das mães de únicos (26,03 anos e 2,14 respectivamente. Verificaram-se números aproximados de partos gemelares e únicos nos diferentes grupos de renda materna analisados. CONCLUSÕES: as mães com idade maior ou igual a 30 anos foram responsáveis pelo aumento da taxa de gêmeos em Pelotas. A média mais elevada de ordem gestacional em mães de gemelares descartou o uso significativo de técnicas de reprodução assistida.OBJECTIVES: to evaluate the prevalence of twin births in Pelotas, Rio Grande do Sul, Brazil, during three periods, and the influence of a number of factors on this occurrence. METHODS: a cross-cutting (multiple time series study was carried out, using the database of the Congenital Defect Monitoring Program, which registers all of the births occurring in the five hospitals of the city of Pelotas, for the years 1993, 1997 and 2003. RESULTS: the mean prevalence of twin births per thousand births (‰ t was 8.95‰ (monozygotic=2.20‰ and dizygotic=6.76‰ . The prevalence of triplets was 0.07‰ . The total prevalence for twin births, in the case of both monozygotic and dizygotic twins rose over the period

  1. Alimentação nos primeiros três meses de vida dos bebês de uma coorte na cidade de Pelotas, Rio Grande do Sul Alimentación en los primeros tres meses de vida de los bebés de una coorte en la ciudad de Pelotas, Rio Grande do Sul (Brasil Feeding during the first three months of life for infants of a cohort in Pelotas, Rio Grande do Sul, Brazil

    Cristina Corrêa Kaufmann

    2012-06-01

    Full Text Available OBJETIVO: Estudar o padrão alimentar nos primeiros três meses de vida de crianças nascidas na cidade de Pelotas (RS. MÉTODOS: Estudo de coorte prospectivo com os bebês nascidos entre setembro de 2002 e maio de 2003, na cidade de Pelotas (RS. Incluíram-se 2.741 bebês nas maternidades e uma amostra aleatória de 30% acompanhada no primeiro e terceiro meses de vida. Foram realizadas análises uni, bi e multivariada. Somente as variáveis com pOBJETIVO: Estudiar el estándar alimentar en los primeros tres meses de vida de niños nascidos en la ciudad de Pelotas (RS, Brasil. MÉTODOS: Estudio de coorte prospectivo con bebés nascidos entre septiembre de 2002 y mayo de 2003, en la ciudad de Pelotas (RS, Brasil. Se incluyó a 2.741 bebés en las maternidades y una muestra aleatoria de 30%, seguida en el primero y el tercero meses de vida. Se realizaron análisis uni, bi y multivariados, y solamente las variables con pOBJECTIVE: To study the feeding pattern in the first three months of babies born in the Pelotas city, in Sothern Brazil. METHODS: Prospective cohort study, with babies born between september 2002 and may 2003. Among 2,741 babies whose mothers were interviewed at the maternity ward, a random sample of 30% was followed up on the first and third months of age. Univariate, bivariate and multivariate analyses were applied. Variables with a p<0.05 were considered as associated. RESULTS: 951 babies were followed up on the first month, 60% were under exclusive maternal breastfeeding, and 10% were already weaned. Smoking during pregnancy, father's educational level lower than four years and the use of a pacifier were associated to weaning. On the third month, 29% had been weaned, 39% received maternal milk exclusively, and 59% were bottle fed. Smoking during pregnancy, father schooling and the use of a pacifier were associated with weaning. There was an increase in the pacifier use - from 56 to 66% between the first and the third month of

  2. Atenção pré-natal em Pelotas, Rio Grande do Sul, Brasil, 1993

    Ricardo Halpern; Barros, Fernando C; Cesar G Victora; Elaine Tomasi

    1998-01-01

    Todos os 5304 nascimentos ocorridos nos hospitais de Pelotas, RS, em 1993, foram estudados. As crianças foram examinadas e suas mães entrevistadas através de um questionário estruturado, onde foram levantadas informações sobre condições demográficas, sócio-econômicas, história reprodutiva e assistência pré-natal. Quase a totalidade das mulheres (95%) realizou acompanhamento durante a gestação. O número médio de consultas foi de 7 e a maioria das mulheres (85%) iniciou o pré-natal antes do qui...

  3. Monitoramento da ação genotóxica em trabalhadores de sapatarias através do teste de micronúcleos, Pelotas, Rio Grande do Sul Monitoring the genotoxic action in shoe workers by micronucleus test, Pelotas, Rio Grande do Sul State

    Natália Silveira Corrêa; Josiana Scherer Bassan; Cristiane de Jesus da Cunha; Ricardo Ramires Fernández; Paula Siqueira Bachettini; Gilberto de Lima Garcias; Maria da Graça Martino-Roth

    2009-01-01

    Neste trabalho, investigou-se a frequência de micronúcleos em células esfoliadas da mucosa bucal de trabalhadores de sapatarias, na cidade de Pelotas (RS). O estudo constou de 54 trabalhadores de sapatarias expostos à cola e solventes e 54 controles. Avaliou-se a incidência de células com micronúcleos(CMN), binucleadas(CBN), núcleos ligados(CNL) e total de anomalias(TA), em 2.000 células por indivíduo. Elaborou-se um banco de dados no programa SPSS "for Windows" pelo teste de Mann-Whitney U, ...

  4. Atenção pré-natal em Pelotas, Rio Grande do Sul, Brasil, 1993 Prenatal care in Pelotas, Rio Grande do Sul, Brazil, 1993

    Ricardo Halpern

    1998-07-01

    Full Text Available Todos os 5304 nascimentos ocorridos nos hospitais de Pelotas, RS, em 1993, foram estudados. As crianças foram examinadas e suas mães entrevistadas através de um questionário estruturado, onde foram levantadas informações sobre condições demográficas, sócio-econômicas, história reprodutiva e assistência pré-natal. Quase a totalidade das mulheres (95% realizou acompanhamento durante a gestação. O número médio de consultas foi de 7 e a maioria das mulheres (85% iniciou o pré-natal antes do quinto mês de gestação. A ausência ao pré-natal foi maior entre as mulheres mais pobres, na maioria adolescentes ou com idade acima de 40 anos. A incidência de baixo peso ao nascer, no grupo que não fez pré-natal, foi de 2,5 vezes maior comparado com as mães que realizaram cinco ou mais consultas. Da mesma forma o coeficiente de mortalidade perinatal foi três vezes maior (50,6/1000 entre as mães que não realizaram pré-natal e aquelas que consultaram 5 ou mais vezes (15,8/1000. Em relação ao risco gestacional que as mães apresentavam, o estudo mostrou uma inversão nos cuidados, já que um quarto das mulheres de alto risco receberam uma atenção pré-natal considerada adequada, enquanto esta proporção era menos de 10% nas mães de risco gestacional mais baixo. Este estudo sugere a necessidade de modificações no atendimento pré-natal, com estratégias bem definidas para aquelas pacientes com alto risco gestacional.All 5304 births in the hospitals of Pelotas, Rio Grande do Sul, Brazil in 1993 were studied. Neonates were examined and their mothers were interviewed regarding sociodemographic conditions, family income, reproductive health, and medical care during pregnancy. Ninety-five per cent of women received prenatal care. The mean number of physician visits during pregnancy was 7 and the majority of the women (84.7% began visits before the fifth month of pregnancy. Women who did not receive prenatal care were from the

  5. Efecto del Cambio de Reglas en Pelota Vasca Escolar

    Oidui Usabiaga Arruabarrena

    2014-01-01

    Full Text Available El objetivo del presente estudio fue analizar la influencia de las modificaciones de reglas en la acción de juego de los escolares que participaron en un programa de deporte escolar de pelota a mano. La muestra estuvo compuesta por 60 escolares de 8 a 12 años, 35 participaron en seis partidos celebrados durante el curso 2007-08 y los 25 restantes en otros seis enfrentamientos del 2008- 09. El registro se llevó a cabo mediante un instrumento observacional ad hoc y posteriormente se realizó un análisis de las variables: zona y tipo de golpe, ubicación espacial en situación de espera y dirección del saque, resto y juego de intercambio. La comparación (curso 2007-08 y 2008-09 de medias se llevó a cabo mediante el test no paramétrico de U de Mann-Whitney (p < 0,05, con corrección de Bonferroni. Los resultados muestran que, después de modificar las reglas, los jugadores de ambos cursos juegan de forma similar: golpean la pelota con la mano derecha en zonas próximas a la pared frontal e izquierda, se ubican a la derecha del jugador que golpea en los duelos por parejas y a la izquierda en los individuales, dirigen los saques a media distancia, cometen faltas en el resto y juego de intercambio y desarrollan un juego a corta distancia. La única diferencia se encontró en el resto a distancia corta y a la derecha. El análisis de indicadores de juego puede ser de gran ayuda para conocer los efectos de los cambios de reglas en el ámbito formativo.

  6. Mortalidade perinatal e infantil em Pelotas, Rio Grande do Sul: nossas estatísticas são confiáveis?

    Fernando C. Barros

    1985-09-01

    Full Text Available Uma coorte de 6.011 crianças vem sendo acompanhada desde o nascimento em Pelotas, RS. A última avaliação foi realizada quando as crianças tinham 20 meses, em média. Este acompanhamento foi feito através de um censo da cidade, quando todas as 68.600 residências foram visitadas, tendo sido localizadas 87,3% das crianças da coorte. Concomitantemente, todos os óbitos foram monitorizados através de visitas domiciliares, revisão periódica de atestados de óbito na Secretaria da Saúde e revisão de prontuários hospitalares. Com o uso dessa metodologia, foi possível detectar 42,1% de sub-registros de mortes perinatais, com 47,8% para óbitos fetais. Com relação à mortalidade infantil, a proporção de sub-registros foi de 24%.A cohort of 6,011 children is being followed up from birth in Pelotas, RS, Brazil. More than 87% of these children were seen when aged 12-27months (mean = 20 months, when all 68,600 urban households were visited. Deaths were monitored through home visits, the review of hospital casenotes and of death certificates at the Secretariat of Health, and these findings were compared with official statistics. Approximately 42% of perinatal deaths failed to be registered, the corresponding figures being 48% for fetal and 24% for infant deaths. On the other hand, less than 5% of all births failed to be registered. The implications of these findings for health policy-makers are discussed.

  7. Seabed acoustic classification in the Pelotas basin, Brazil

    Paloma Lumi Costa

    2013-03-01

    Full Text Available The present study sought to develop a seabed map of the region of the Pelotas Basin using acoustic methods. A total number of 1,507,823 seabed reflectivity data, collected during six oceanographic surveys, were processed to generate a seabed map. Data processing consisted of the classification of the acoustic parameter BSBS (Bottom Surface Backscattering Strength obtained with the Scientific Echosounder EK 500 operating at a frequency of 38 kHz. BSBS is expressed in decibels (dB, and corresponds to a logarithm of the ratio between incident acoustic energy and the energy reflected by the seabed. Four BSBS value classes, associated with different sediment types, were established. High BSBS values are associated with coarse sediments, whereas low values indicate fine sediments. A seabed reflectivity map was generated using the Natural Neighbor method to interpolate the BSBS values organized according to the pre-established classes. Four features with high BSBS values were identified at 100-200 m depth. The largest one was found in the region of Santa Marta Cape and attributed mainly to consolidated seabed and/or the presence of biodetritic material, according to comparison with maps available in the literature. Above 500m depth, there was a predominance of acoustically low reflectivity sea floor, which was attributed to the presence of muddy sediment. Considering the lack of information on the seabed at great depths, the acoustic method was shown to be an alternative tool to obtain data on seabed characteristics in these regions.O presente estudo teve como objetivo principal a realização de um mapeamento de fundo, através de metodologia acústica, para a região da Bacia de Pelotas. Um total de 1.507.823 dados de refletividade de fundo provenientes de seis Cruzeiros Oceanográficos foi processado para elaboração de um mapa de refletividade de fundo. Esse processamento consistiu numa classificação dos valores do parâmetro acústico BSBS

  8. RS-predictor

    Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik; Huang, Tao-wei; Bennett, Kristin P; Breneman, Curt M

    2011-01-01

    -validated RS-Predictor models were generated for a set of 394 substrates of CYP 3A4 as a proof-of-principle for the method. Rank aggregation was then employed to merge independently generated predictions for each substrate into a single consensus prediction. The resulting consensus RS-Predictor models were...

  9. Macroinvertebrados bentônicos como indicadores de qualidade de água na Barragem Santa Bárbara, Pelotas, RS, Brasil Zoobenthics as indicators of the water quality in the Santa Bárbara Dam, Pelotas, RS, Brazil

    Sérgio Renato Noguez Piedras

    2006-04-01

    Full Text Available O objetivo deste trabalho foi estudar o impacto de dois afluentes da barragem Santa Bárbara sobre o ambiente da mesma, utilizando a ocorrência de invertebrados bentônicos e características químicas da água. Durante nove meses foram realizadas coletas e análises da água e de invertebrados bentônicos nos afluentes Sanga da Barbuda e Sanga do Passo do Cunha e também no interior da bacia de acumulação da barragem. Os resultados mostram que, embora a Sanga da Barbuda e a Sanga do Passo do Cunha apresentem características químicas abaixo do recomendável, no limite aceitável pela legislação que determina os padrões de qualidade da água para abastecimento público, estes afluentes estão, ainda, sendo diluídos de forma satisfatória na bacia de acumulação da barragem. O estudo das relações entre variáveis químicas e invertebrados bentônicos mostra haver correlação significativa entre os baixos níveis de oxigênio dissolvido e a presença de Oligochaeta, sendo que o aumento do número de Oligochaeta indica uma situação de anoxia na barragem Santa Bárbara.The objective of this work was to study the impact of two tributaries from the Santa Bárbara Dam on this environment using the occurrence of zoobenthics and some water chemical characteristics. Monthly gathering and analysis from the water and zoobenthics were done during nine months in the tributaries Sanga da Barbuda and Sanga Passo do Cunha as well as in the inner part of the accumulation basin in the Santa Barbara dam. The results demonstrate that, though Sanga da Barbuda and Sanga Passo do Cunha present chemical characteristics lower than the recommended but still in the limits acceptable by the law that regulates the water quality standards for the supply, these tributaries are being diluted in a satisfactory way in the accumulation basin in the Santa Barbara dam. The study of the relations between chemical variables and zoobenthics show a significant correlation between low levels of dissolved oxygen and the presence of Oligochaeta; moreover, the increase of Oligochaeta indicates a situation of anoxia in the Santa Barbara Dam.

  10. Epidemiologia das polidactilias: um estudo de casos e controles na população de Pelotas-RS Epidemiology of polydactylies: a case-control study in the population of Pelotas-RS

    Marcelo Boeing

    2001-04-01

    Full Text Available OBJETIVO: o alvo deste estudo caso-controle de base hospitalar foi identificar e comparar casos de polidactilia isolada com recém-nascidos normais, considerando as características familiares e maternas. MÉTODOS: os dados foram coletados através de entrevista com mães de casos e controles, no período pós-parto, de 1990 a 1998. Os casos foram definidos como recém-nascidos apresentando um dígito extra ou bífido nas mãos e/ou pés. Os controles foram os quatro recém-nascidos normais que nasceram após o caso, no mesmo hospital. Foram obtidas informações sobre o tipo de polidactilia, sexo e peso do recém-nascido, gemelaridade, consanguinidade parental, etnicidade, entre outras. RESULTADOS: a ancestralidade africana e a história familiar positiva de malformação congênita, especialmente de polidactilia, foram significantemente associados com a ocorrência desse tipo de anomalia congênita (OR bruto de 3,3; 10,0; e 55,0; respectivamente. CONCLUSÕES: na população estudada a polidactilia isolada é uma das malformações mais freqüentes. Os achados de associação com etnicidade negro-africana confirmam dados da literatura. Estudos nesta mesma população, com um número maior de portadores desta malformação, poderiam melhorar o poder de associação e justificar os resultados apresentados.OBJECTIVE: to identify and compare cases of isolated polydactyly with healthy newborns regarding familial and maternal characteristics. METHODS: we conducted this hospital-based case-control study from 1990 to 1998. We collected data in interviews with mothers of cases and controls during the post-delivery period. Cases were defined as newborns presenting an extra or a bifid digit in hands and/or feet. Controls were the four healthy newborns that were born after the case, at the same hospital. Information was gathered on type of polydactyly, gender and birthweight, twin pregnancy, parental consanguinity, ethnicity. RESULTS: African ancestry and positive family history of congenital malformation, especially polydactyly, were significantly associated with the occurrence of this type of congenital anomaly (crude OR of 3.3; 10.0; and 55.0, respectively. CONCLUSION: isolated polydactyly was one of the most frequent malformations found in the studied population. The findings associated with black African ancestry confirm the data presented in the literature. Studies conducted on this same population, with a larger population of patients with this type of malformation, could investigate this association better and justify the results presented here.

  11. Auditoria Médica: atendimento de crianças com asma em uma Unidade de Saúde da Família, Pelotas, RS Medical Auditing: care to asthmatic children in a Family Health Unit, Pelotas, RS

    Ana Maria Siga Stephan

    2009-06-01

    Full Text Available Descrição do processo de atendimento médico às crianças com asma, mediante auditoria realizada concomitantemente a estudo transversal, conduzido em crianças da área de cobertura de uma Unidade de Saúde da Família, para verificar a prevalência de asma e avaliar o conhecimento materno sobre a doença. Utilizaram-se como fonte de dados os prontuários de família das crianças com asma que se consultaram nos últimos 12 meses. Das 258 crianças com asma identificadas no estudo, 69 (26,7% tinham registros de consultas devido à doença. Havia registros de peso em 76,8% dos prontuários, de frequência respiratória em 26,1%, de tiragem intercostal em 21,7%, de cianose em 1,4% e de orientações sobre o uso da medicação em 33,3%. A frequência de registros de orientações sobre os sinais e sintomas de gravidade e o manejo das crises foi de 15,9% e sobre os fatores desencadeantes, modificações ambientais e comportamentais, 14,5%. Foram encontrados registros de prescrição de broncodilatador para 55,1% das crianças, e de corticoesteroide mais broncodilatador para 42,0%. Os baixos percentuais de registros sobre orientações evidenciam as deficiências no atendimento médico realizado na Unidade de Saúde da Família, sobretudo no que se refere à educação em saúde.This is a description of the process of medical care to children with asthma, through an audit carried out concomitantly with a cross-sectional study with children living in the catchment area of a Family Health Unit, to find the prevalence of asthma and to assess maternal knowledge about the disease. Medical records of families whose children had asthma and visited doctors in the previous 12 months were used as sources of data. Of the 258 children identified with asthma, 69 (26.7% had visited the unit because of the disease. Weight was recorded in 76.8% of the medical records, respiratory frequency in 26.1%, intercostal retractions in 21.7%, cyanosis in 1.4%, and orientations on the use of medication in 33.3%. Orientations on the signs and symptoms of severity and crisis management were recorded in 15.9% of the charts and trigger factors, environmental changes, and behavior were recorded in 14.5% of them. There were records of prescription of bronchodilators for 55.1% of the children and of bronchodilator plus corticosteroid for 42.0% of them. The low percentage of records of orientation is an evidence of the deficiencies of medical care in Family Health Units, especially regarding education in health.

  12. RS-WebPredictor

    Zaretzki, J.; Bergeron, C.; Huang, T.-W.;

    2013-01-01

    Regioselectivity-WebPredictor (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOMs) on drug-like molecules. Predictions may be made for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19 and 2E1....... RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects.......Availability: RS-WebPredictor is accessible for free use at http://reccr.chem.rpi.edu/ Software/RS-WebPredictor. © 2013 The Author....

  13. Anencefalia: um estudo epidemiológico de treze anos na cidade de Pelotas Anencephaly: thirteen years of epidemiological study in Pelotas city

    Ricardo Ramires Fernández; Daniela Zílio Larentis; Tiago Fontana; Gustavo Pêgas Jaeger; Patrick Botelho Moreira; Gilberto de Lima Garcias; Maria da Graça Martino Roth

    2005-01-01

    A anencefalia é a forma letal mais comum dentre as anomalias do SNC. Apesar dos casos isolados, a anencefalia parece ser de causa multifatorial. Este defeito ocorre devido a um não fechamento da extremidade anterior do sulco neural. Este trabalho, que tem como objetivo estudar a freqüência, a etiologia e os fatores predisponentes desta malformação, é um estudo de caso-controle de base populacional que abrange todos os nascimentos ocorridos nas cinco maternidades da cidade de Pelotas, durante ...

  14. Taming troubled teens: The social production of mental morbidity amongst young mothers in Pelotas, Brazil

    Behague, DP; Gonçalves, HD; Gigante, D.; Kirkwood, BR

    2012-01-01

    Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this paper explores the hypothesis that teen childbearing and subsequent mental morbidity have become associated through the interplay of culture, society,...

  15. [MaRS Project

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  16. Anencefalia: um estudo epidemiológico de treze anos na cidade de Pelotas Anencephaly: thirteen years of epidemiological study in Pelotas city

    Ricardo Ramires Fernández

    2005-03-01

    Full Text Available A anencefalia é a forma letal mais comum dentre as anomalias do SNC. Apesar dos casos isolados, a anencefalia parece ser de causa multifatorial. Este defeito ocorre devido a um não fechamento da extremidade anterior do sulco neural. Este trabalho, que tem como objetivo estudar a freqüência, a etiologia e os fatores predisponentes desta malformação, é um estudo de caso-controle de base populacional que abrange todos os nascimentos ocorridos nas cinco maternidades da cidade de Pelotas, durante o período de 1º de janeiro de 1990 a 31 de dezembro de 2002.The anencephaly is the most common lethal form among the CNS anomalies. Although isolated cases occur, the anencephaly seems to be caused by multiple factors. This malformation result from closure defects of the anterior neural sulk, during embryonic development. The aim of this study was analyze the frequency, etiology, and the risk factors of this congenital malformation. This population-based case-control study range all births occurred in five maternities of Pelotas city from January, 1st 1990 to December, 12 2002.

  17. Biochronostratigraphy of the Pelotas Basin: Actual state and application in the petroleum geology; Biocronoestratigrafia da Bacia de Pelotas: estado atual e aplicacao na geologia do petroleo

    Anjos-Zerfass, Geise de Santana dos; Souza, Paulo Alves de; Chemale Junior, Farid [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Inst. de Geociencias]. E-mails: geise.anjos@ufrgs.br; paulo.alves.souza@ufrgs.br, farid.chemale@ufrgs.br

    2008-07-01

    The bio stratigraphic studies of the Brazilian sedimentary basins have providing a support for the exploratory research of energetic and mineral resources, in particular at the continental margin. From new discoveries of hydrocarbon accumulations at the Santos and Campos basins, the south portion of the Brazilian continental margin were converted in an important target of the exploration. Therefore, the bio stratigraphic refinement is necessary to detect gaps and to promote an increment on the precision of the lateral correlations in the delimitation and spatial analysis of the potential reservoirs. The actual stage of the bio-chronostratigraphic framework of the Pelotas Basin is presented herein, focusing on its application to the reservoir prospection. The main questions and lacunae on the knowledge are also discussed. In terms of bio stratigraphy, the Pelotas Basin remains poorly evaluated, despite publication of important works on the bio stratigraphy are known since the 1960's. A comparison of bio stratigraphic schemes proposed for the Tertiary section of the basin allows the inference of diverse hiatuses, identified by the absences of bio zones. Hiatuses identified in the {sup 87}Sr/{sup 86}Sr curve, suggest their relationship with discontinuities in the deposition. Discrepancies between the proposed schemes can be attributed to the particular resolution of the different groups used, the variations in the bio stratigraphic criteria and the sampling interval, influencing the bio stratigraphic resolution and therefore its potential as a correlation tool. (author)

  18. Trails, RS2477, RS2477, Published in 2005, Daggett County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'RS2477'. Data by this publisher are often provided...

  19. RS-232 Led Board

    Tskhvaradze, Vladimir

    2007-01-01

    This article demonstrates how to develop a Microchip PIC16F84 based device that supports RS-232 interface with PC. Circuit (LED Board) design and software development will be discussed. PicBasic Pro Compiler from microEngineering Labs, Inc. is used for PIC programming. Development of LED Board Control Console using C/C++ is also briefly discussed. The project requires basic work experience with Microchip PICs, serial communication and programming.

  20. Enfermidade e morte: os escravos na cidade de Pelotas, 1870-1880 Illness and death: slaves in the city of Pelotas, 1870-1880

    Beatriz Ana Loner

    2012-12-01

    Full Text Available Analisa as doenças apresentadas pelos escravos internados na Santa Casa de Misericórdia de Pelotas. O foco recai sobre os trabalhadores das charqueadas que cumpriam rotina intensa e rígida, o que ocasionava sérias consequências para a saúde. Apesar de haver muitas descrições do processamento da carne nas charqueadas, são bem menores as preocupações com a forma como o trabalho escravo era exercido. Com a análise do período entre 1870 e 1880, a partir dos livros de internamento, de observações de viajantes e de jornais, pretende-se contribuir para maior conhecimento das condições de saúde dos cativos na região sul do estado gaúcho.The article analyzes diseases presented by slaves hospitalized at Santa Casa de Misericórdia in Pelotas. The focus is on the workers at 'charqueadas' (processing plants for dried meat, whose harsh and rigid work regimen had serious health consequences. Although we can find many descriptions of beef processing at 'charqueadas', we find less evidence of concerns about how slave labor was employed at these plants. By analyzing the period from 1870 to 1880, based on hospital records, travelers' observations, and newspaper reports, the article intends to contribute towards a better understanding of the health conditions of captives in the southern part of the state of Rio Grande do Sul.

  1. Monitoramento da ação genotóxica em trabalhadores de sapatarias através do teste de micronúcleos, Pelotas, Rio Grande do Sul Monitoring the genotoxic action in shoe workers by micronucleus test, Pelotas, Rio Grande do Sul State

    Natália Silveira Corrêa

    2009-12-01

    Full Text Available Neste trabalho, investigou-se a frequência de micronúcleos em células esfoliadas da mucosa bucal de trabalhadores de sapatarias, na cidade de Pelotas (RS. O estudo constou de 54 trabalhadores de sapatarias expostos à cola e solventes e 54 controles. Avaliou-se a incidência de células com micronúcleos(CMN, binucleadas(CBN, núcleos ligados(CNL e total de anomalias(TA, em 2.000 células por indivíduo. Elaborou-se um banco de dados no programa SPSS "for Windows" pelo teste de Mann-Whitney U, pIn this paper it was investigated the micronuclei frequency in exfoliated oral mucosa cells in shoe shop workers in the city of Pelotas, RS. The study counted on 54 shoe workers exposed to glue and solvents and 54 controls. It was evaluated the incidence of cells with micronucleus (CMN, bi-nucleus (CBN, linked nucleus (CLN and total amount of anomalies (TAA, in 2000 cells per person. A database was created in the SPSS "for Windows" software using the Mann-Whitney U, p<0.05 test. The average of anomalies among shoe workers was 8.69±6.49CMN; 8.85±4.92CBN; 5.78±4.78CNL; 23.31±10.01TA, in the controlled 4.00±5.05CMN; 4.63±4.35CBN; 4.76±5.00CNL; 13.39±9.43TA (p=0.0001; p=0.0001; p=0.144 and p=0.0001 respectively. It was also evaluated the age, gender, time of work, family income, smoke, alcohol beverages, the influence of dermatological, ophthalmological, respiratory and central nervous system (CNS diseases in the number of cell anomalies. These items did not have any influence. It was only observed that among the age group of 15 to 29 years old the number of CNL was bigger than among the age group of 45 to 72. Among those with time of work of 0.1 and 10 years presented a higher CNM than in the other group range.

  2. Self-Medication Among Adolescents Aged 18 Years: The 1993 Pelotas (Brazil) Birth Cohort Study

    Bertoldi, Andréa Dâmaso; Camargo, Aline Lins; Silveira, Marysabel Pinto Telis; Ana M. B. Menezes; Assunção, Maria Cecília Formoso; Gonçalves, Helen; Hallal, Pedro Curi

    2014-01-01

    Purpose To estimate the point prevalence of self-medication among adolescents aged 18 years and to evaluate the type of drugs used (either over-the-counter or prescription drugs) and socioeconomic, health-related, and behavioral correlates of self-medication. Methods This cross-sectional study used data from the 1993 Pelotas (Brazil) Birth Cohort Study. Data were obtained through the administration of a questionnaire to adolescents aged 18 years. The outcome variables were point prevalence of...

  3. The Pelotas Birth Cohort Study, Rio Grande do Sul, Brazil, 1982-2001

    2010-01-01

    Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil) birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries) were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed. PMID:14666206

  4. Uso estratégico del espacio en categorías de formación de pelota vasca. [Strategic use of space in basque pelota training categories].

    Oidui Usabiaga

    2014-04-01

    Full Text Available La pelota vasca es un deporte de pelota compuesto por varias especialidades. La pelota a mano es una de las más practicadas y se juega tanto en duelos individuales como por equipos. El presente estudio pretende analizar y comparar algunos indicadores de juego del uso estratégico del espacio por parte de jugadores benjamines (8-10 años y alevines (10-12 años que participan en un programa de deporte escolar. La muestra estuvo compuesta por doce partidos, seis de benjamines (30 participantes y seis de alevines (30 participantes. El registro se llevó a cabo mediante un instrumento observacional ad hoc diseñado para analizar el uso estratégico del espacio por parte de los participantes, tanto cuando golpean la pelota como cuando están en situación de espera. Los resultados muestran que los participantes de las dos categorías usan el espacio de la misma forma respecto a las zonas de golpe, la ubicación espacial en situación de espera durante los duelos por parejas y los tipos de saque. Los alevines, en comparación a los benjamines, se posicionan más a la derecha del jugador que golpea durante los duelos individuales, dirigen la pelota a distancias medias y cometen menos faltas tanto en el resto del saque como en el juego de intercambio, dando mayor continuidad al juego (p Abstract The basque pelota is a ball sport composed of various specialties. The hand pelota is one of the most popular and is played in both individual and team matchups. The aim of this study was to analyze and compare some indicators of the strategic use of space by young players, 8-10- and 10-12-year-old students, participating in a school sport program. The sample consisted of twelve games, six for each level (30 participants for each level. Data were recorded with an ad hoc observational instrument designed to analyze the strategic use of space by the participants, both when they hit the ball and when they are on standby. The results show that the participants of

  5. The Pelotas birth cohort study, Rio Grande do Sul, Brazil, 1982-2001 Estudo de coorte de nascimentos em Pelotas, Rio Grande do Sul, Brasil, 1982-2001

    Cesar G. Victora

    2003-10-01

    Full Text Available Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed.Em função do reconhecimento crescente do enfoque do ciclo vital na determinação de doenças crônicas, estudos de coorte de nascimentos são cada vez mais importantes. Este artigo descreve a metodologia do estudo de coorte de nascidos em Pelotas, em 1982, um dos maiores e mais longos estudos de coorte em países em desenvolvimento. Todos os 5.914 nascimentos hospitalares (mais de 99% de todos os nascimentos ocorridos em 1982 foram estudados prospectivamente. As principais fases do estudo foram realizadas em 1983, 1984, 1986, 1995, 1997, 2000 e 2001. Mais de duas mil variáveis estão disponíveis para sujeitos incluídos em todas as fases do estudo. As fases recentes

  6. Fatores de risco para a asma em adultos, Pelotas, Rio Grande do Sul, Brasil Risk factors for asthma in adults in Pelotas, Rio Grande do Sul State, Brazil

    Silvia Elaine Cardozo Macedo

    2007-04-01

    Full Text Available A incidência e mortalidade por asma vêm aumentando em vários países do mundo. Com o objetivo de avaliar a prevalência e fatores de risco para a asma na população adulta de Pelotas, Rio Grande do Sul, Brasil, conduziu-se um estudo populacional e transversal, em amostra de 1.968 pessoas, dos 20 a 69 anos de idade. A prevalência de "sintomas atuais de asma" foi de 6%, observando-se variação com diferentes critérios diagnósticos. Na análise bruta, os fatores de risco observados foram: sexo feminino, faixa etária dos 60 aos 69 anos, cor da pele não-branca, baixas escolaridade e renda familiar, história familiar de asma e atopia, atopia pessoal, tabagismo, índice de massa corporal baixo e distúrbios psiquiátricos menores. Na análise multivariada permaneceram os seguintes fatores de risco: história paterna e materna de asma, distúrbios psiquiátricos menores, idade de 60 a 69 anos, renda familiar inferior a 1,01 salário mínimo, atopia pessoal e sexo feminino. Os resultados salientam a variação na prevalência de asma com diferentes critérios diagnósticos, e que fatores genéticos, sociais e relacionados ao estilo de vida são relevantes na ocorrência da doença.Asthma incidence and mortality rates have increased in recent years. The present cross-sectional survey aimed to measure asthma prevalence and risk factors in a random sample of 1,968 individuals (20-69 years of age in Pelotas, Rio Grande do Sul State, Brazil. Overall prevalence of "current asthma symptoms" was 6%, varying according to diagnostic criteria. Associated risk factors in the crude analyses were: female gender, age 60-69 years, non-white skin color, low education, low family income, family history of atopy and asthma, personal history of atopic disease, smoking, low body mass index, and minor psychiatric disorders. In the multivariate analysis the following risk factors remained associated with "current asthma symptoms": mother and father with asthma

  7. Leisure-time physical activity during pregnancy in the 2004 Pelotas Birth Cohort Study Atividade física de lazer entre as gestantes da coorte de nascimentos de Pelotas de 2004

    Marlos Rodrigues Domingues

    2007-04-01

    Full Text Available OBJECTIVE: Physical activity during pregnancy is a poorly investigated subject on population level. The study aimed to describe duration, type and frequency of leisure-time physical activity during pregnancy, and to explore its associated factors. METHODS: A population-based study was carried out during 2004 in Southern Brazil. A total of 4,471 mothers were interviewed soon after delivery. Physical activity was measured using a questionnaire, developed for the study. Results were obtained by Poisson regression. RESULTS: In the sample, 14.8% of women reported to engage in some type of physical activity prior to pregnancy and 12.9% during pregnancy. In the first trimester, 10.4% of all mothers engaged in some type of physical activity; 8.5% in the second trimester and 6.5% in the third trimester. Only 194 mothers (4.3% were active during the whole pregnancy. In the adjusted analysis, leisure-time physical activity was positively associated with schooling, physical activity advice during prenatal care, and family income (pOBJETIVO: A atividade física durante a gestação é pouco estudada em nível populacional. O objetivo do estudo foi descrever a duração, tipo e freqüência de atividade física de lazer durante a gravidez e explorar fatores associados. MÉTODOS: Estudo de base populacional, realizado durante o ano de 2004 em Pelotas, RS, Brasil. Logo após o parto, 4.471 mães foram entrevistadas. Utilizou-se questionário, desenvolvido para o estudo, para verificar a atividade física de lazer. Os resultados foram obtidos por regressão de Poisson. RESULTADOS: Antes da gravidez, 14,8% das mulheres relataram algum tipo de atividade física de lazer e durante, 12,9%. No primeiro trimestre, 10,4% de todas as mães fizeram alguma atividade física de lazer; no segundo, 8,5% e no terceiro, 6,5%. Apenas 194 mães (4,3% foram ativas durante toda a gestação. Na análise ajustada, atividade física de lazer esteve positivamente associada com

  8. RELATÓRIO DO PROJETO DE PESQUISA: "AVENDANO JÚNIOR:ATRADIÇÃO DO CHORO EM PELOTAS"

    Ana Silveira

    2012-09-01

    Full Text Available O projeto de pesquisa "Avendano Júnior: A Tradição do Choro em Pelotas"é desenvolvido sob a coordenação do Prof. Ms. Raul Costa d'Avila 88 , do Conservatório de Música da Universidade Federal de Pelotas, que percebendo a dimensão interdisciplinar do mesmo, decide realizá-lo em parceria com oLaboratório de Ensino e Pesquisa em Antropologia e Arqueologia (LEPAARQ -UFPel. Trata-se de um projeto que envolve três áreas de conhecimento, Música, Antropologia e História, tendo como foco de análise central a figura do compositor e cavaquinista Joaquim Assumpção Avendano Júnior, bem como o Grupo Musical que o acompanha, o Regional.

  9. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis

    Enevold, Christian; Baslund, Bo; Linde, Louise;

    2014-01-01

    Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously report...

  10. Predictors and Health Consequences of Screen-Time Change During Adolescence—1993 Pelotas (Brazil) Birth Cohort Study

    Dumith, Samuel Carvalho; Leandro Martin Totaro GARCIA; da Silva, Kelly Samara; Menezes, Ana Maria Baptista; Hallal, Pedro Curi

    2012-01-01

    Purpose To investigate screen-time change from early to mid adolescence, its predictors, and its influence on body fat, blood pressure, and leisure-time physical activity. Methods We used data from a longitudinal prospective study, conducted among participants of the 1993 Pelotas (Brazil) Birth Cohort Study. At baseline, adolescents were, on average, 11 years old. They were later visited at age 15 years. Screen time was self-reported, accounting for the time spent watching television, playing...

  11. Antenatal and postnatal maternal mood symptoms and psychiatric disorders in pre-school children from the 2004 Pelotas Birth Cohort

    Iná S Santos; Matijasevich, Alicia; Barros, Aluísio J D; Fernando C. Barros

    2014-01-01

    Background Maternal mood symptoms have been associated with psychiatric disorders in children. This study aimed to assess critical periods when maternal symptoms would be more deleterious. Methods Cohort of 4231 births followed-up in the city of Pelotas, Brazil. Mood symptoms during pregnancy were self-reported by mothers at perinatal interview; and at 3-months postpartum, mothers answered the Self-Reporting Questionnaire. Psychiatric disorders in 6-year-old children were evaluated through th...

  12. Methods and logistics of a multidisciplinary survey of schoolchildren from Pelotas, in the Southern Region of Brazil Métodos y logística de un estudio multidisciplinar con escolares de Pelotas, sur de Brasil Métodos e logística de um estudo multidisciplinar com escolares de Pelotas, Sul do Brasil

    Marlos Rodrigues Domingues; Margarete Marques; Dione Dias Torriani; Fabiana Vargas-Ferreira; Marcos Britto Correa; Marília Leão Goettems; Pedro Curi Hallal; Flávio Fernando Demarco

    2013-01-01

    This paper describes the methods of a multidisciplinary epidemiological survey conducted in schools in Pelotas, in the Southern Region of Brazil. This cross-sectional study evaluated a representative sample (n = 1,211) of eight to 12-year-old children attending public (15) and private (5) schools. Questionnaires were applied to parents to obtain information about socioeconomic and sociocultural characteristics. Children were interviewed to provide information on demographic characteristics, o...

  13. Taming troubled teens: the social production of mental morbidity amongst young mothers in Pelotas, Brazil.

    Béhague, D P; Gonçalves, H D; Gigante, D; Kirkwood, B R

    2012-02-01

    Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this paper explores the hypothesis that teen childbearing and subsequent mental morbidity have become associated through the interplay of culture, society, and biology in situations where teen pregnancy has become a stigmatised object of scientific and public health attention. Results show that the effect of teen childbearing on subsequent mental morbidity remained significant in the multivariate analysis. Ethnographic analysis, together with epidemiological effect modification analyses, suggest that this association is partially accounted for by the fact that it is more pronounced amongst a specific subgroup of women of low socio-economic status who, being more politicised about societal injustice, were also more critically engaged with - and thus troubled by - the inequitable institutionalisation of life-cycle transitions. With time, these women became highly critical of the institutionalised identification of early childbearing as a key violation of life-cycle norms and the differential class-based application of scientific knowledge on its causes and consequences. Public health campaigns should consider how the age-based institutionalisation of developmental norms has enabled the stigmatisation of those identified as transgressors. PMID:22196249

  14. Criminal victimization in childhood and adolescence according to official records: the Pelotas (Brazil) birth cohort study.

    Gallo, Erika Alejandra Giraldo; Menezes, Ana Maria B; Murray, Joseph; Silva, Luciana Anselmi Duarte da; Wehrmeister, Fernando César; Gonçalves, Helen; Barros, Fernando

    2016-01-01

    This article describes different types of officially recorded victimization among 5,249 children in the 1993 birth cohort in the city of Pelotas, Rio Grande do Sul State, Brazil. Official data were obtained from the Secretariat for Public Security and the Special Court for Children and Youth. Victimization was registered for in 1,150 cohort members, with 1,396 incidents recorded as of December 31, 2012. The total incidence of victimization was 15.7 ocorrences per 1,000 person-years, with the majority involving violent victimization (12.7 per 1,000 person-years). Victimization increased gradually in childhood and rapidly throughout adolescence. The highest incidence rates were among females (p < 0.05), the poor (p < 0.05), children of adolescent mothers (p < 0.001), and children of single mothers (p < 0.05). The most common violent victimization types were physical injuries, robbery, and crimes against personal freedom; non-violent victimization mainly involved theft. Studies like this help identify lifetime risk and protective factors for victimization, highlighting the importance of surveillance and control measures against violence. PMID:27580232

  15. Autoavaliação de saúde e doenças crônicas entre enfermeiros de Pelotas/RS

    Adrize Rutz Porto

    2013-09-01

    Full Text Available Descrever a autoavaliação de saúde e a prevalência de doenças crônicas entre enfermeiros. Estudo transversal, realizado com 240 enfermeiros que responderam a questionário estruturado. Fez-se o tratamento dos dados por meio de estatística descritiva e associações com o teste qui-quadrado. A amostra foi composta por enfermeiros, em sua maioria mulheres (90,8% adultas jovens (69,6%, não casadas (55,4% e com filhos (53,4%. Na amostra, 35,4% relataram trabalhar mais de 40h, 40% trabalhavam no período noturno, 31,2% conviviam com doenças crônicas e 37,1% avaliaram sua saúde de razoável a ruim. Obteve-se associação significativa entre doenças crônicas, idade superior a 39 anos (p<0,001 e autoavaliação de razoável a ruim sobre a saúde (p<0,001. Diante dos achados, emerge a necessidade de investimentos na assistência à saúde dos enfermeiros, principalmente no que tange ao convívio com doenças crônicas, o que, por conseguinte, influenciará na autoavaliação da saúde desses profissionais e no cuidado prestado.

  16. Elaboración y validación biomecánica de un guante de protección para jugar a pelota valenciana. (Elaboration and biomechanical validation of a protection glove for playing pelota valenciana.

    Carlos Montaner-Sesmero

    2012-10-01

    Full Text Available ResumenLa pelota valenciana es uno de los antiguos juegos de pelota a mano que perdura en la Comunidad Valenciana. Para amortiguar los impactos de la pelota durante el golpeo, los jugadores se confeccionan sus propias protecciones. En torno a ellas existen diversos factores que dificultan la práctica segura y eficaz de este deporte: el excesivo tiempo empleado en su elaboración, el elevado número de lesiones que sufren en las manos o el inadecuado control de la pelota que consiguen. En base a esto y a la inexistencia de un equipamiento deportivo específico para la mano, se ha desarrollado y validado un guante para intentar solventar estos inconvenientes. En la validación biomecánica se comparó el guante con una protección tipo a nivel de presiones palmares y de precisión y distancia alcanzada en el golpeo. También se registró la opinión de los jugadores acerca del guante con una encuesta. En el ensayo biomecánico participaron 15 jugadores. Para el registro de las presiones palmares se utilizó el equipo Biofoot/IBV® adaptado a la mano. Los resultados muestran que el guante disminuye la presión en tres zonas de la mano, que ofrece la misma precisión y que favorece una mayor distancia de golpeo que las protecciones tradicionales. Los jugadores han valorado satisfactoriamente aspectos como la usabilidad, el ajuste y el confort térmico. En consecuencia, el guante desarrollado disminuye el tiempo de colocación, ofrece mejores prestaciones de protección y es valorado positivamente por los jugadores.Abstract The pelota valenciana game is one of the ancient ball hand game that lasts in the Valencian Community. The players, in order to cushion the hand impacts of the ball during the hits, make their own protections. Around them there are several factors that impede the safe and effective practice of this sport: the excessive time spent in the manufacture, the high number of hand injuries suffered or the inappropriate control of the

  17. Incidência e fatores de risco para tuberculose em Pelotas, uma cidade do Sul do Brasil Incidence and risk factors for tuberculosis in Pelotas, a city in the South of Brazil

    Ana M. B. Menezes

    1998-04-01

    Full Text Available Objetivou-se medir a incidência e avaliar fatores de risco para tuberculose, em adultos de Pelotas. Os casos foram detectados na "Secretaria Municipal da Saúde e Bem Estar" (Centro de Saúde, no período de junho de 1994 a junho de 1995. Concomitante, controles populacionais, pareados por sexo e idade, eram sorteados e aplicado o mesmo questionário aos casos e controles. A incidência notificada de tuberculose foi de 72,4/100.000 habitantes. A análise estatística bruta mostrou os seguintes odds ratios: 10,8 (classe social E, 5,4 (renda familiar The aim of this study was to evaluate the incidence and risk factors for tuberculosis, in adults from Pelotas. Cases were recruited in the Sanitary Unit of Tuberculosis (June/1994 to June/1995. At the same time, population controls matched by sex and age were randomly selected, and the same questionnaire was applied for cases and controls. The notified incidence of tuberculosis in Pelotas was 72.4/100.000 inhabitants. Statistical analysis showed the following crude odds ratios: 10.8 (social class E, 5.4 (family income < 1 minimum salary and 6.6 (illiterate people. The risk for non-whites was 4.7; crowding and history of contact with tuberculosis presented risks of 3.1 and 5.3, respectively. Alcoholism presented a risk of 4.3 and diseases associated with tuberculosis presented a risk of 3.6; history of diabetes and living near mines did not show an association with tuberculosis. Mine workers had a risk of 4.0. In the multivariate analysis using conditional logistic regression the following risks remained statistically significant after controlling for confounding factors: contact with tuberculosis (8.2, alcoholism (4.0, mine worker (4.7 and non-white (3.1. The incidence of tuberculosis in Pelotas is very high and most risk factors are preventable and can be reduced.

  18. Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results Estudos de saúde bucal na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: metodologia e resultados principais

    Peres, Marco A; Aluísio Jardim Barros; Karen Glazer Peres; Cora Luiza Araújo; Ana M. B. Menezes; Hallal, Pedro C; Victora, Cesar G

    2010-01-01

    The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, rangin...

  19. Variations in influenza vaccination coverage among the high-risk population in Sweden in 2003/4 and 2004/5: a population survey

    van Essen Gerrit A

    2007-06-01

    Full Text Available Abstract Background In Sweden, the vaccination campaign is the individual responsibility of the counties, which results in different arrangements. The aim of this study was to find out whether influenza vaccination coverage rates (VCRs had increased between 2003/4 and 2004/5 among population at high risk and to find out the influence of personal preferences, demographic characteristics and health care system characteristics on VCRs. Methods An average sample of 2500 persons was interviewed each season (2003/4 and 2004/5. The respondents were asked whether they had had an influenza vaccination, whether they suffered from chronic conditions and the reasons of non-vaccination. For every county the relevant health care system characteristics were collected via a questionnaire sent to the medical officers of communicable diseases. Results No difference in VCR was found between the two seasons. Personal invitations strongly increased the chance of having had a vaccination. For the elderly, the number of different health care professionals in a region involved in administering vaccines decreased this chance. Conclusion Sweden remained below the WHO-recommendations for population at high risk due to disease. To meet the 2010 WHO-recommendation further action may be necessary to increase vaccine uptake. Increasing the number of personal invitations and restricting the number of different administrators responsible for vaccination may be effective in increasing VCRs among the elderly.

  20. Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts

    Matijasevich, Alicia; Murray, Elizabeth; Stein, Alan; Anselmi, Luciana; Menezes, Ana M; Santos, Iná S; Barros, Aluísio JD; Gigante, Denise P.; Barros, Fernando C; Cesar G Victora

    2014-01-01

    Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low- and middle-income countries, and very few covering the preschool period. The aim was to investigate changes in preschool behavioral/emotional problems in two birth cohorts from a middle-income country born 11 years apart. Methods We analyzed data from the 1993 and 2004 Pelotas birth cohort studies from Brazil. A subsample of 4-year olds from the 1993 cohort (63...

  1. Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

    Marco A Peres; Barros, Aluísio Jardim; Peres, Karen Glazer; Araújo, Cora Luiza; Ana M. B. Menezes; Hallal, Pedro C; Victora, Cesar G.

    2010-01-01

    The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, rangin...

  2. Uso del espacio en pelota vasca en edad escolar: aplicación del análisis secuencia

    Usabiaga, Oidui; Castellano, Julen; Anguera Argilaga, María Teresa

    2016-01-01

    El presente estudio aborda la búsqueda de patrones de conducta asociados al uso del espacio llevadas a cabo por jugadores benjamines (8-10 años) y alevines (10-12 años) de pelota a mano que participan en deporte escolar. La muestra estuvo compuesta por doce partidos (60 jugadores), seis de benjamines (30 jugadores) y seis de alevines (30 jugadores). El registro se llevó a cabo mediante un instrumento de observación diseñado ad hoc para analizar el uso estratégico del espacio...

  3. Pelotas as seen through the eyes of its street children. : An empirical investigation of the child-friendliness of a midsize Brazilian city

    Lehtikunnas, Katri

    2009-01-01

    Lehtikunnas, Katri Johanna (2009). Pelotas as seen through the eyes of its street children. An empirical investigation of the child-friendliness of a midsize Brazilian city. Human Geography, advanced level, master thesis for master exam in Human Geography, 30 ECTS credits. Supervisor: Maria Nordström Language: English   The aim of this study was to understand the lives of the street children in Pelotas in Southern Brazil. Utilizing multi-method approach I have outlined normal days of these ch...

  4. Cobertura do exame citopatológico na cidade de Pelotas, Rio Grande do Sul, Brasil

    Juvenal Soares Dias-da-Costa

    2003-02-01

    Full Text Available No Brasil, a avaliação da efetividade de programas de prevenção e ações de saúde pública ainda são incipientes. Dessa forma, realizou-se um estudo transversal de base populacional envolvendo a saúde da população adulta residente na zona urbana da cidade de Pelotas, Rio Grande do Sul, Brasil, com o objetivo de verificar a evolução nos níveis de cobertura do exame citopatológico. Investigaram-se fatores associados com a não realização do procedimento. Considerou-se exame citopatológico atualizado aquele realizado nos últimos três anos. A amostra foi constituída por 1.122 mulheres entre 20 e 69 anos, sendo que 72,2% apresentavam exame citopatológico atualizado, 16,6% atrasado e 11,2% nunca o haviam realizado. A não realização do procedimento esteve associada com baixa inserção social e idade avançada. A regressão logística destacou o efeito independente de classe social, baixa renda familiar, idade, cor da pele, estado civil e ausência de consultas médicas no último ano. Contudo, desapareceu o efeito detectado em mulheres com doenças crônicas. Comparando-se os resultados do estudo realizado em 1992 com o atual, observa-se que a cobertura do exame aumentou de 65,0% para 72,2% (1992 para 1999/2000, entretanto, não atingiu os níveis efetivos para evitar câncer de colo uterino.

  5. Lithogeochemistry of the main unities of Pelotas batholith from Rio Grande do Sul State

    The Pelotas batholith is composed predominantly of a Cambrian multi-intrusive granitic complex (Dom Feliciano Granitic Suite) associated to rhyolitic dike swarms and small basic plutons. The Piratini Gneisses (Late Riphean -Vendian) correspond to calcalkaline dioritic-tonalitic-granodioritic orthogneisses with chemical features of pre-collisional granitoids related to oceanic crust subduction (B-subduction) under an active continental margin. The Pinheiro Machado Granitoids (Vendian) are alkali-calcic granodiorite-monzogranites with Caledonian-type characteristics, but appear to also correspond to pre-collisional granitoids as a latter and more mature phase in the evolution of the magmatic arc. The Dom Feliciano Granitic Suite (Cambrian) is subdivided into porphyritic and equigranular facies, with predominance of monzogranites and syenogranites, respectively, with alkali-calcic late-orogenic characteristics. While the Rb/Sr isotopic data is consistent with the proposed evolution, the Nd model ages range from 2.0 - 1.2 Ga. This may reflect episodes of Sm/Nd fractionation within a lithospheric mantle instead of the accretion age of the granitoids. These apparent ages, which are also obtained in Parana and Karroo continental basalts, probably indicate coupled evolution of the continental crust and lithospheric mantle. In the suggested model, the Piratini Gneisses were orginated by differentiation of basic magmas formed by partial melting of lithospheric mantle, induced by dehydration of subducted oceanic crust, while the more mature arc granitoids had increasing crustal contamination or mingling-mixing with crustal melts and finally, in the late-and post-orogenic stages, partial melting of continental crust predominates. (author)

  6. Formas de condicionar la verdad con el uso del montaje en La pelota vasca

    María Antonia Paz Rebollo

    2011-01-01

    Full Text Available Esta investigación tiene como objetivo estudiar la construcción de sentido en La pelota vasca. La piel contra la piedra (Julio Medem, 2003, el documental sobre terrorismo que más éxito comercial y más polémica ha generado en el cine español. A través de un análisis del montaje, este artículo busca descubrir las pautas, esquemas o estructuras narrativas utilizadas por el director para construir el texto fílmico y para influir en la opinión de los espectadores. Para ello se ha creado una base de datos que permite un minuicioso análisis cuantitativo y cualitativo de todAs las intervenciones que hay en la película. Esta propuesta metodológica pretende servir al análisis de otros documentales con similares características narrativas. Las conclusiones obtenidas muestran que el director usa la estructura de parte del documental y las entrevistas a diferentes personalidades del País Vasco para configurar un sentido propio de lo que denomina conflicto vasco, que está muy cercano a las tesis nacionalistas. Queda demostrada la crítica a la acción del PP en sus años de gobierno y el deterioro de la imagen del Estado, principalmente a través de un 80% de referencias negativas sobre las fuerzas de seguridad del Estado. También se prueba que las personas entrevistadas son más o menos creíbles dependiendo de cómo quedan situadas dentro del montaje y de si otros personajes refutan o respaldan lo que dicen.

  7. Trabalho infantil em Pelotas: perfil ocupacional e contribuição à economia

    Facchini Luiz Augusto

    2003-01-01

    Full Text Available O trabalho infantil é um fenômeno global de grandes proporções, especialmente em países em desenvolvimento. Estima-se que, em todo o mundo, 352 milhões de crianças e adolescentes menores de 18 anos são economicamente ativos, incluindo atividades remuneradas, trabalho não-pago, ilegal e no setor informal da economia. No Brasil, cerca de 9,3 milhões de crianças entre 10 e 17 anos trabalham. Os estudos sobre a contribuição econômica das crianças à renda familiar são escassos. Este artigo apresenta o perfil ocupacional e a contribuição econômica de crianças e adolescentes, com destaque para aspectos relacionados à idade, ao gênero, à escolaridade e à situação socioeconômica de suas famílias em uma amostra de 4.924 indivíduos entre 6 e 17 anos, representativa dos setores urbanos pobres de Pelotas. As crianças e adolescentes trabalhadores contribuíam em média com 18% da renda familiar. Dos que trabalhavam, metade contribuía no mínimo com 10% da renda familiar e um quarto respondia por 25% ou mais da renda familiar. Quanto menor a renda familiar dos adultos, maior a proporção da contribuição de crianças e adolescentes à renda familiar total, maior a exclusão escolar de adolescentes trabalhadores e maior a jornada de trabalho infanto-juvenil.

  8. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    Lílian Moura de Lima; Camila Cardoso de Oliveira; Katiuscia Milano Rosales de Rodrigues

    2011-01-01

    A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info...

  9. Use of contraceptive methods by sexually active teenagers in Pelotas, Rio Grande do Sul State, Brazil Uso de métodos anticoncepcionais em adolescentes sexualmente ativos de 15 a 18 anos em Pelotas, Rio Grande do Sul, Brasil

    Clarissa Lisbôa Arla da Rocha

    2007-12-01

    Full Text Available This study aimed to assess the prevalence of contraceptive use by adolescents. A cross-sectional study was performed from March to September 2002 in a representative sample of adolescents 15 to 18 years of age in the urban area of Pelotas, Rio Grande do Sul State, Brazil. Multiple-stage sampling was used, and in the 448 census tracts located in the urban area, 90 were sampled and households were visited in each tract. Information was collected on sexual initiation and use of contraceptive methods. Chi-square test was used to compare proportions. The sample included 960 adolescents. 88% of subjects reported the use of any contraceptive method. Condoms were the most commonly used method (63.2%. Low adolescent schooling was the only variable associated with increased risk of non-use of contraceptives. Condom use was higher among males, adolescents whose mothers had 9 or more years of schooling, and those reporting several sexual partners in the previous year. Condoms were the most commonly used contraceptive method.O estudo avaliou o uso de métodos contraceptivos em adolescentes. Entre março e setembro de 2002, realizou-se um estudo transversal na zona urbana da cidade de Pelotas, Rio Grande do Sul, Brasil. A amostragem foi em múltiplos estágios, 90 dos 448 setores censitários da zona urbana de Pelotas foram sorteados e em cada setor 86 residências foram visitadas. Considerou-se a informação do adolescente sobre a prática de relações sexuais e do uso de métodos contraceptivos. Nas comparações entre as proporções utilizou-se o teste do qui-quadrado. Foram entrevistados 960 adolescentes, enquanto que para 79 não foi possível realizar a entrevista. Aproximadamente 88% dos adolescentes usavam algum método contraceptivo. O preservativo masculino foi encontrado como o método mais usado naqueles adolescentes que têm relação sexual (63,2%. A escolaridade do adolescente foi a única variável associada com o uso de contraceptivos. O

  10. O ofício de vender o que se ama?: as narrativas de donos de sebos em Pelotas = Is it a craft to sell what one loves?: the narrativas of sebo owners in Pelotas city

    Marcello Neto, Mario

    2014-01-01

    Full Text Available Este trabalho pretende problematizar a memória construída pelos donos de sebos na cidade de Pelotas. Sebo é o nome atribuído as lojas de vendas de livros, discos (LP’s e quadrinhos usados, porém a origem do termo é de difícil definição (BRITO, 1991. Utilizando a metodologia da História Oral Temática (PORTELLI, 1997 realizamos entrevistas nas quais os narradores compartilharam a sua memória sobre o seu ofício, sua origem e sua importância social para a cidade. Ao total foram 4 narradores, donos e fundadores dos maiores sebos da cidade de Pelotas. Pretendemos problematizar a experiência (THOMPSON, 1991 diferenciada que cada narrador possui sobre o seu ofício. Muitos se consideram bibliófilos (colecionadores de obras raras e valiosas e para isso recorrem à venda de obras “menores” para que possam adquiri-las; outros apenas tratam seu trabalho como um negócio; e ainda há quem classifique o seu trabalho como essencial para a disseminação da leitura na cidade. Nosso objetivo neste trabalhão é compreender a construção dessa memória e a formação de identidade em relação a esse ofício (CANDAU, 2011, bem como a representação (CHARTIER, 1991 que estes narradores fazem de sua inserção na sociedade, o seu papel social. Para muito desses narradores, a metade final do século XX foi definidora para que hoje a demanda por sebos na cidade seja cada vez maior. Porém, nosso objetivo é compreender as narrativas sobre a origem desse ofício, bem como compreender a sua relação para com os objetos vendidos, se há ou não uma relação comercial e/ou afetiva para com os livros e quadrinhos, bem como problematizar a sua memória sobre o seu papel social na disseminação da leitura em Pelotas.

  11. Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) genes in Thai cervical cancer patients with HPV 16 infection.

    Chansaenroj, Jira; Theamboonlers, Apiradee; Junyangdikul, Pairoj; Swangvaree, Sukumarn; Karalak, Anant; Chinchai, Teeraporn; Poovorawan, Yong

    2013-01-01

    The risk of cervical cancer development in women infected with HPV varies in relation to the individual host's genetic makeup. Many studies on polymorphisms as genetic factors have been aimed at analyzing associations with cervical cancer. In this study, single nucleotide polymorphisms (SNPs) in 3 genes were investigated in relation to cervical cancer progression in HPV16 infected women with lesions. Two thousand cervical specimens were typed by PCR sequencing methods for TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566). Ninety two HPV16 positive cases and thirty two normal cases were randomly selected. Analysis of TP53 (rs1042522) showed a significantly higher frequency in cancer samples (OR=1.22, 95%CI=1.004-1.481, p-value=0.016) while differences in frequency were not significant within each group (p-value=0.070). The genotype distributions of p16 (rs11515 and rs3088440) and NQO1 (rs1800566) did not show any significantly higher frequency in cancer samples (p-value=0.106, 0.675 and 0.132, respectively) or within each group (p-value=0.347, 0.939 and 0.111, respectively). The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women. Further studies of possible mechanisms of influence on cervical cancer development would be useful to manage HPV infected patients. PMID:23534750

  12. Funcionalidad de la articulación glenohumeral en el golpe de drive en pelota a paleta

    Doussouk, Karim; Doussouk, Adiel

    2013-01-01

    El propósito de esta ponencia, es realizar un análisis del gesto técnico denominado “Drive”, golpe determinante en la disciplina de Pelota a Paleta, a partir del estudio Anatómico y Biomecánico de la articulación Glenohumeral. Se destacará la importancia de los conocimientos anatomo-funcionales en la formación del Profesor en Educación Física, como base para el análisis del movimiento en cuestión, ya sea con fines de rendimiento deportivo o para mejorar la intervención docente. La articula...

  13. Intensity-duration-frequency ratios obtained from annual records and partial duration records in the locality of Pelotas - RS, Brazil Relações intensidade-duração-frequência obtidas a partir de séries anual e de duração parcial para a localidade de Pelotas-RS

    Claudia F. A. Teixeira

    2011-01-01

    Full Text Available The intensity-duration-frequency occurrence ratio (IDF is a tool commonly used for precipitation-runoff data transformation, which is established from observations of intense precipitations over a period sufficiently long as to allow the occurrence of extremes at the observation site. This study focused on verifying the existence or absence of new data, in terms of IDF ratio, by using partial duration records produced from data on maximum daily disaggregated rainfall for pre determined durations. The partial duration records considered a base value of 55 mm, totaling 279 values. After the rainfall series were established, their independence and seasonality were assessed. Using the Student's t-test statistics, it was established that no new data, as IDF ratio, emerged from the analysis of the partial duration series with the recommended base value of precipitation, as compared to the historical records.A relação intensidade-duração-frequência de ocorrência (IDF é uma ferramenta utilizada nos processos de transformação chuva-vazão, e sua determinação deve ser obtida a partir de observações de chuvas intensas, durante um período de tempo longo e representativo dos eventos extremos do local. O presente trabalho teve como objetivo verificar a existência ou não de ganho de informação, em termos de relação IDF, ao serem utilizadas séries de duração parcial, a partir dos dados de chuva máxima diária desagregada, em durações preestabelecidas. Quanto à série de duração parcial, foi utilizado o valor-base preestabelecido de 55 mm, constituindo então 279 valores. Posteriormente à constituição das séries de chuva, foi avaliada a independência e a estacionaridade dos valores contidos nas mesmas. Pela metodologia do teste "t" de Student, constatou-se que não há ganho de informação em termos de relação IDF quando utilizada a série de duração parcial, com o valor-base preestabelecido de precipitação, comparativamente à série de registros históricos.

  14. Characterization of Listeria monocytogenes isolated from a fresh mixed sausage processing line in Pelotas-RS by PFGE Caracterização de Listeria monocytogenes isoladas em uma linha de processamento de lingüiça mista frescal em Pelotas-RS por PFGE

    Ana Eucares von Laer

    2009-09-01

    Full Text Available Listeria monocytogenes is a bacterium capable to adhere to the surfaces of equipment and utensils and subsequently form biofilms. It can to persist in the food processing environmental for extended periods of time being able to contaminate the final product. The aim of this study was to trace the contamination route of L. monocytogenes on a fresh mixed sausage processing line, from raw material to the final product. The isolates obtained were characterized by serotyping and molecular typing by pulsed-field gel electrophoresis (PFGE using the restriction enzymes ApaI and AscI. L. monocytogenes was detected in 25% of the samples. The samples of raw material were not contaminated, however, the microorganism was detected in 21% of the environmental samples (food contact and non-food contact, 20.8% of the equipments, 20% of the food worker's hands, 40% of the mass ready to packaging and in all the final products samples, demonstrating that the contamination of final product occurred during the processing and the importance of cross contamination. PFGE yielded 22 pulsotypes wich formed 7 clusters, and serotyping yielded 3 serotypes and 1 serogroup, however, the presence of serotypes 4b and 1/2b in the final product is of great concern for public health. The tracing of contamination showed that some strains are adapted and persisted in the processing environment in this industry.Listeria monocytogenes é uma bactéria com capacidade de formar biofilmes e de colonizar superfícies de equipamentos e utensílios. Esse microrganismo pode persistir por longos períodos em plantas de processamento de alimentos, sendo capaz de contaminar o produto final. O objetivo deste estudo foi traçar a rota de contaminação de L. monocytogenes em uma linha de processamento de lingüiça mista frescal, desde a matéria-prima até o produto final. Os isolados obtidos foram caracterizados por sorotipagem e por tipagem molecular, através de Pulsed Field Gel Electrophoresis (PFGE, usando as enzimas de restrição ApaI and AscI. L. monocytogenes foi detectada em 25% das amostras. Nenhuma amostra da matéria-prima apresentava o patógeno, entretanto, o microrganismo foi detectado em 21% das amostras ambientais (com e sem contato com o alimento, 20,8% dos equipamentos, 20% das amostras de mãos de manipuladores, 40% da massa pronta para o embutimento, e em todas as amostras do produto final. Isso demonstra que a contaminação do produto final ocorreu durante o processamento, e a importância da contaminação cruzada. PFGE produziu 22 pulsotipos e a sorotipagem produziu 3 sorotipos e 1 sorogrupo, entretanto, a presença dos sorotipos 4b e 1/2b no produto final é de grande importância para a saúde pública. Os perfis de macrorestrição mostraram que algumas cepas são adaptadas e persistiram no ambiente de processamento dessa indústria.

  15. Rs6454674, Rs806368 and Rs1049353 CNR1 Gene Polymorphisms in Turkish Bipolar Disorder Patients: A Preliminary Study

    Gokay Alpak

    2014-04-01

    Full Text Available Bipolar disorder (BD is one of the most prevalent psychiatric disorders in clinical practice. The etiology of the BD is not thoroughly understood. Endocannabinoid system, which is involved in regulation of emotion, stress, memory, and cognition, may have an important role in the pathophysiology of BD. Mutations on the cannabinoid-1 receptor (CNR1 gene are associated with several psychiatric disorders. The main cannabinoid (CB receptor is CB1 and its activation inhibits neuronal depolarization. One previous study showed rs1049353 polymorphism of CNR1 gene is associated with major depression but not with BD. In this study, we aimed to investigate the rs6454674, rs806368 and rs1049353 CNR1 gene polymorphisms in Turkish BD patients. A total of 96 patients and 58 healthy controls were included in the current case-control study. Blood samples of study participants were collected into sterile tubes and processed to obtain genomic DNA. Restriction Fragment Length Polymorphism analysis were done by digesting the PCR products with HpyCH4III and BseGI enzymes for the rs6454674 and rs806368 restriction sites, respectively. Single-Strand Conformation Polymorphism (SSCP analysis was also performed. Among three polymorphisms investigated in this study, only rs6454674 polymorphism was significantly different between BD patients and controls (rs6454674 T/G; p=0.042, rs806368 T/C; p>0.05, rs1049353 A/G; p>0.05. Furthermore, we found that the mean of the yearly manic attacks was statistically higher in patients who have heterozygote (0.91+/-0.67 rs6454674 T/G polymorphisms compared to those with homozygote (p=0.043 polymorphism. The post-hoc analysis showed that the main differences were between the heterozygotes genotype and non-mutant (GG homozygotes (0.42+/-0.31; p=0.037 but not in homozygote mutant genotype (0.74+/-0.74; p=0.149. When patients were compared with the other clinical parameters, and mutated alleles and genotypes for each polymorphism, we did not

  16. A SURVEY OF ORAL AND MAXILLOFACIAL BIOPSIES IN CHILDREN. A SINGLE-CENTER RETROSPECTIVE STUDY OF 20 YEARS IN PELOTAS-BRAZIL

    Giana da Silveira Lima; Silvia Terra Fontes; Lenita Maria Aver de Araújo; Adriana Etges; Sandra Beatriz Chaves Tarquinio; Ana Paula Neutzling Gomes

    2008-01-01

    Despite the large number of published cases about oral and maxillofacial pediatric lesions, the literature is scarce on epidemiological studies regarding the prevalence of these entities. This study retrieved oral and maxillofacial pediatric lesions from the Center of Diagnosis of Oral Diseases (CDDB) at the Dental School of the Federal University of Pelotas (UFPEL), comprising a 20-year period (1983-2002). From the total of 9,465 biopsies received in this period, 625 (6.6%) were from childre...

  17. Estudio experimental controlado y aleatorizado sobre la efectividad y seguridad del uso de la pelota de parto durante el trabajo de parto

    Delgado García, Beatriz Elena

    2015-01-01

    La presente tesis fue financiada por el Fondo de Investigación Sanitarias del Instituto Carlos III, dependiente del Ministerio de Ciencia e Innovación, con el registro PI09/90257 y el proyecto de investigación titulado "Estudio experimental controlado y aleatorizado para evaluar la efectividad y seguridad del uso de la pelota de parto durante el trabajo del parto y el parto.

  18. Comparison of Vaisala radiosondes RS41 and RS92 at the ARM Southern Great Plains site

    Jensen, Michael P.; Holdridge, Donna J.; Survo, Petteri; Lehtinen, Raisa; Baxter, Shannon; Toto, Tami; Johnson, Karen L.

    2016-07-01

    In the fall of 2013, the Vaisala RS41 (fourth generation) radiosonde was introduced as a replacement for the RS92-SGP radiosonde with improvements in measurement accuracy of profiles of atmospheric temperature, humidity, and pressure. In order to help characterize these improvements, an intercomparison campaign was undertaken at the US Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility site in north-central Oklahoma, USA. During 3-8 June 2014, a total of 20 twin-radiosonde flights were performed in a variety of atmospheric conditions representing typical midlatitude continental summertime conditions. The results show that for most of the observed conditions the RS92 and RS41 measurements agree much better than the manufacturer-specified combined uncertainties with notable exceptions when exiting liquid cloud layers where the "wet-bulbing" effect appears to be mitigated for several cases in the RS41 observations. The RS41 measurements of temperature and humidity, with applied correction algorithms, also appear to show less sensitivity to solar heating. These results suggest that the RS41 does provide important improvements, particularly in cloudy conditions. For many science applications - such as atmospheric process studies, retrieval development, and weather forecasting and climate modeling - the differences between the RS92 and RS41 measurements should have little impact. However, for long-term trend analysis and other climate applications, additional characterization of the RS41 measurements and their relation to the long-term observational records will be required.

  19. Qualidade do ambiente e fatores associados: um estudo em crianças de Pelotas, Rio Grande do Sul, Brasil Quality of the environment and associated factors: a pediatric study in Pelotas, Rio Grande do Sul, Brazil

    Maria de Fátima Duarte Martins

    2004-06-01

    Full Text Available Descrever e identificar fatores que possam estar associados à qualidade do ambiente e características das crianças expostas, em Pelotas, Rio Grande do Sul, Brasil. Trata-se de um estudo prospectivo de caráter populacional, incluindo 630 crianças da coorte de nascimentos de 1993. No ano de 1998 avaliou-se, entre outras informações, a qualidade do ambiente, medida através do Home Observation for the Measurement of the Environment. Os dados foram analisados por meio de análise univariada. A associação entre as variáveis e o desfecho foi avaliada por meio das razões de prevalência, dos intervalos de confiança em 95% e do qui-quadrado. Realizou-se a regressão logística seguindo modelo hierarquizado. Constatou-se que 97 crianças (15% viviam em ambiente negativo. Encontraram-se oito fatores de risco associados à qualidade do ambiente: baixa renda familiar mensal, baixa escolaridade materna, sexo masculino, casas com mais de sete residentes, número de irmãos maior ou igual a quatro, uso de tabaco na gestação, crianças que dormem na cama dos pais aos 4 anos e mães com presença de transtornos psiquiátricos.This study aims to describe and identify factors associated with environmental quality and characteristics of children exposed to environmental risk factors in Pelotas, Rio Grande do Sul, Brazil. This was a prospective, population-based study, including 630 children from the 1993 birth cohort. During the year 1998, environmental quality and other information were assessed using the Home Observation for the Measurement of the Environment. Data were submitted to univariate analysis. The association between the variables and the outcome was evaluated through prevalence ratios, 95% confidence intervals, and chi-square. Logistic regression was performed according to a hierarchical model. Some 97 children (15% were living in negative environments. Eight risk factors were associated with environmental quality: low monthly family

  20. Oral health follow-up studies in the 1993 Pelotas (Brazil birth cohort study: methodology and principal results Estudos de saúde bucal na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: metodologia e resultados principais

    Marco A. Peres

    2010-10-01

    Full Text Available The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359 and 12 (n = 339 years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6 for the entire sample, ranging from 0.6 (SD = 1.1 for children that were caries-free at age six, 1.3 (SD = 1.5 for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8 for those with 4-19 carious teeth at six years (p O objetivo deste trabalho foi descrever estudos de saúde bucal em uma coorte de nascimentos. Em 1993, teve início uma coorte de nascimentos de base populacional em Pelotas, Rio Grande do Sul, Brasil. Dois estudos de saúde bucal aos 6 (n = 359 e 12 anos de idade (n = 339 foram realizados. Foi observada uma alta taxa de resposta no período entre 6 e 12 anos de idade; 94,4% das crianças pesquisadas em 1999 foram examinadas em 2005. A média do índice CPO-D aos 12 anos foi de 1,2 (DP = 1,6 para a população como um todo, variando de 0,6 (DP = 1,1 para o grupo livre de cáries aos 6 anos, 1,3 (DP = 1,5 para os que apresentaram 1-3 dentes atacados pela cárie e 1,8 (DP = 1,8 para aqueles com 4-19 dentes atacados pela cárie (p < 0,01. Observou-se um aumento da proporção de indivíduos com oclusopatias muito severas aos 12 anos, conforme o número de oclusopatias presentes aos 6 anos de idade. Problemas bucais no início da adolescência foram mais prevalentes nos indivíduos que apresentaram agravos à saúde bucal na infância.

  1. Prevalence of suicide risk and comorbidities in postpartum women in Pelotas Prevalência do risco de suicídio e de comorbidades em mulheres pós-parto em Pelotas

    Daniele Tavares

    2012-10-01

    Full Text Available OBJECTIVES: To evaluate the prevalence of suicide risk and comorbidities in postpartum women. METHODS: This is a cross-sectional study of postpartum women. The sample comprised mothers who have received prenatal care from the Brazilian National System of Public Heath in the city of Pelotas. Suicide risk and other mental disorders were evaluated using the Mini International Neuropsychiatric Interview (MINI. A yes answer on one of the six interview questions was considered a sign of suicide risk. RESULTS: The sample consisted of 919 postpartum women. The 11.5% suicide prevalence was 4.62 (CI 2.45, 8.73 times higher in women with low educational levels. Women with comorbid depression or an anxiety disorder showed a 17.04 (CI 2.27; 19.96 times greater risk of suicide than those who did not suffer from any mood disorder. CONCLUSION: Lower education levels and psychiatric disorders are associated with suicide risk. Bipolar disorder is the psychiatric disorder with the highest impact on suicide risk.OBJETIVOS: Avaliar a prevalência do risco de suicídio e de comorbidades em mulheres pós-parto. MÉTODOS: Este foi um estudo em corte transversal com mulheres pós-parto. A amostra foi constituída de mães que receberam cuidados pré-natais prestados pelo Sistema Nacional de Saúde Pública do Brasil na cidade de Pelotas. O risco de suicídio e outros transtornos mentais foram avaliados pela Mini International Neuropsychiatric Interview (MINI. Uma resposta afirmativa a qualquer das seis perguntas é considerada um risco de suicídio. RESULTADOS: A amostra consistiu de 919 mulheres pós-parto. A prevalência do risco de suicídio foi de 11,5%. Ela foi 4,62 vezes mais alta (IC de 95% 2,45; 8,73 em mulheres de baixo nível educacional. Mulheres apresentando qualquer comorbidade para depressão e transtornos ansiosos tiveram uma chance 17,04 vezes maior (IC 95% 2,27; 19,96 àquelas que não apresentaram nenhum transtorno afetivo. CONCLUSÃO: Um n

  2. Adesão à terapêutica da tuberculose em Pelotas, Rio Grande do Sul: na perspectiva do paciente Tuberculosis treatment adherence in Pelotas, Brazil, from the patient's perspective

    Helen Gonçalves

    1999-10-01

    Full Text Available O trabalho aborda a adesão ao tratamento da tuberculose dentro do universo composto por homens e mulheres doentes e as conexões e conseqüências da doença na seu modo/fase de vida e no resultado final do tratamento. O estudo etnográfico, como um sub-estudo do Projeto Controle Epidemiológico da Tuberculose na Cidade de Pelotas, Rio Grande do Sul, propunha-se, inicialmente, verificar as razões existentes para que os pacientes não completassem o tratamento. Utilizou-se o método etnográfico de observação direta, conjugado com as entrevistas semi-estruturadas. A opção pela utilização do termo adesão é justificada pela preocupação em abranger outros fatores fundamentais, além da responsabilidade individualizada do enfermo. Esta abordagem possibilitou compreender as concepções de doença, as dinâmicas sociais entre os diversos protagonistas envolvidos no processo da doença e seu tratamento. Levaram-se em consideração alguns dos fatores implicados na adesão ao tratamento: características sócio-demográficas, fatores culturais, crenças populares, relação de custo benefício, aspectos físicos e químicos dos medicamentos, interação médico paciente e grau de participação familiar no tratamento.This study deals with adherence to tuberculosis treatment among men and women as well as the disease's links and consequences vis-à-vis life styles and treatment outcomes. The ethnographic study was a component of the Tuberculosis Epidemiological Control Project in the city of Pelotas and aimed to identify the reasons patients failed to complete treatment. Direct ethnographic observations and semi-structured interviews were used. Use of the term "adherence" is justified by the concern for extending to other fundamental factors in addition to the patient's own individual responsibility. This approach fostered an understanding of views towards disease, social dynamics among the various protagonists involved in the disease process

  3. Auto-estima e fatores associados em gestantes da cidade de Pelotas, Rio Grande do Sul, Brasil Self-esteem and associated factors in pregnant women in the city of Pelotas, Rio Grande do Sul State, Brazil

    Michelle de Souza Dias

    2008-12-01

    Full Text Available O estudo tem como objetivo mensurar a auto-estima e fatores associados em gestantes atendidas pelo Sistema Único de Saúde (SUS na cidade de Pelotas, Rio Grande do Sul, Brasil. É do tipo transversal, tendo-se entrevistado 560 gestantes nos meses de maio a novembro de 2006, nos ambulatórios e enfermarias dos hospitais universitários e do centro de atendimento da Prefeitura Municipal. Dentre as gestantes atendidas, 62,9% receberam o diagnóstico de alto-risco. Para avaliação da auto-estima foi utilizada a escala de Rosenberg. Na amostra total a média de pontos na escala foi de 9,2 e o desvio-padrão de 4,6. As variáveis associadas positiva e significativamente com auto-estima foram idade, nível de escolaridade e nível econômico. Já as variáveis percepção de risco à saúde do bebê e número de gestações mostraram-se associadas negativamente à auto-estima. Além disso, as gestantes com condição gestacional de alto-risco têm uma auto-estima mais elevada quando comparadas com as de baixo-risco.This study analyzes self-esteem and associated factors in pregnant women treated by the Unified National Health System (SUS in the city of Pelotas, Rio Grande do Sul State, Brazil. Using a cross-sectional design, 560 pregnant women were interviewed from May to November 2006. The interviews were held in specific locations like University outpatient clinics and hospital wards and a center run by the city government. A full 62.9% were diagnosed as high-risk pregnancies. Mean self-esteem according to the Rosenberg scale was 9.2 (SD = 4.6. Variables showing a positive, significant association with self-esteem were age, schooling, and income. Perception of risk to the unborn infant's health and parity were both negatively associated with maternal self-esteem. These high-risk pregnant women also showed higher self-esteem than low-risk pregnant women.

  4. Environment sensitivity map to North Pelotas Basin: subsidy to elaboration of contingency plans; Mapeamento da sensibilidade ambiental para a porcao norte da Bacia de Pelotas: subsidio para elaboracao de planos de contingencia

    Diniz, Debora P.; Griep, Gilberto H. [Fundacao Universidade do Rio Grande (FURG), RS (Brazil)

    2008-07-01

    The Pelotas Basin stands out in the national scenery of search of petroleum and gas. Due of these interests they become important environmental protection actions. Inside of this panorama is the Chart of Sensitivity Index (CSI). The study was developing in Santa Catarina, municipal districts from Passo de Torres to Palhoca. The objectives of this work were the development of the CSI and the construction of a bibliographical database. The methodology used in this work was proposed by the Ministerio do Meio Ambiente. During the field exit sediment samples, photographic registration and pertinent observation were collected. With all this information the Index of Environment Sensitivity (IES) was generated, that classifies the coasts in agreements with the sensitivity to the oil. Diversity of environments is very clear at this coast for the variability of the IES. The most frequent ecosystem is beaches of medium to fine sand exposed. It was identified the presence of environments of highly sensitive, classified in the index 8 and 10. The definition of possible scarification areas was accomplishments with IES, biological resources and economical partner of the area. (author)

  5. Methods and logistics of a multidisciplinary survey of schoolchildren from Pelotas, in the Southern Region of Brazil Métodos y logística de un estudio multidisciplinar con escolares de Pelotas, sur de Brasil Métodos e logística de um estudo multidisciplinar com escolares de Pelotas, Sul do Brasil

    Marlos Rodrigues Domingues

    2013-05-01

    Full Text Available This paper describes the methods of a multidisciplinary epidemiological survey conducted in schools in Pelotas, in the Southern Region of Brazil. This cross-sectional study evaluated a representative sample (n = 1,211 of eight to 12-year-old children attending public (15 and private (5 schools. Questionnaires were applied to parents to obtain information about socioeconomic and sociocultural characteristics. Children were interviewed to provide information on demographic characteristics, oral health behavior and physical activity habits. Oral health examinations were performed on the children and anthropometric data was collected to assess nutritional status. School principals responded a questionnaire about the social and physical environment of the school. A total of 1,744 children were eligible for the study; a response rate of 69.4% was achieved, with no significant differences between schools. The method used allowed investigators to obtain data on several health outcomes as well as on possible risk factors. This strategy optimizes the use of financial resources for research and promotes interprofessional collaboration.El artículo detalla los métodos de un estudio epidemiológico multidisciplinar llevado a cabo en escuelas en Pelotas, sur de Brasil. El estudio transversal incluyó una muestra representativa (n = 1.211 de niños de 8 a 12 años, en escuelas públicas (15 y privadas (5. Los cuestionarios fueron administrados a los padres para obtener información socioeconómica y cultural. Los niños fueron entrevistados, proporcionando información demográfica, comportamientos de salud bucal y práctica de actividad física. Se realizaron un examen de salud bucal y medidas antropométricas para la evaluación de la condición nutricional. Directores de escuelas proporcionaron información sobre el ambiente físico y social de las escuelas. De los 1.744 niños elegibles, la tasa de respuesta fue de un 69,4% sin diferencias entre escuelas

  6. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    Lílian Moura de Lima

    2011-03-01

    Full Text Available A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info 6.04. Como principal resultado encontrou-se a maior ocorrência de acidentes de trabalho com material biológico entre os profissionais técnicos em enfermagem do sexo feminino (38,6%, com idade de 21 a 30 anos (53,9%. A maioria dos acidentes aconteceu através de lesões com perfurocortantes (82,2%, sendo 24,1% no Centro Cirúrgico e 84,5% envolvendo sangue. Conclui-se que o estudo é de extrema relevância, pois, com base no reconhecimento do tipo de acidentes mais frequentes, pode-se conhecer os riscos existentes e intervir na sua redução, por meio de ações preventivas que beneficiem o trabalhador e a instituição.El estudio aborda la exposición ocupacional a material biológico a que fueron sometidos los profesionales de salud en el Hospital Santa Casa de Misericordia de Pelotas, de enero de 2004 a junio de 2008. Este es un corte transversal, descriptivo y cuantitativo. Se utiliza como herramienta de investigación un cuestionario basado en el formulario de informe de accidente de trabajo de esa institución. Los datos fueron introducidos y analizados con Epi-Info 6.04. Como principal resultado se encontró una mayor incidencia de accidentes con material biológico entre los profesionales técnicos de enfermería del sexo femenino (38,6%, de 21 años a 30 años (53,9%. La mayoría de los accidentes ocurrió a través de lesiones con objetos punzantes (82,2%, siendo que 24,1% ocurrió en el Centro Quirúrgico, y 84,5% con sangre. Se

  7. [Physical activity, screen time, and use of medicines among adolescents: the 1993 Pelotas (Brazil) birth cohort study].

    Bergmann, Gabriel Gustavo; Bertoldi, Andréa Dâmaso; Mielke, Grégore Iven; Camargo, Aline Lins; Matijasevich, Alicia; Hallal, Pedro Curi

    2016-01-01

    This study aimed to evaluate cross-sectional and longitudinal associations between physical activity, screen time, and use of medicines among adolescents from the 1993 Pelotas (Brazil) birth cohort study, followed at 11 (N = 4,452), 15 (N = 4,325), and 18 years of age (N = 4,106). The study recorded the use of medicines in the previous 15 days, continuous use of some medication, level of physical activity (by questionnaire and accelerometry), and screen time (TV, computer, and videogame). One-third of adolescents had used at least one medicine in the previous 15 days and approximately 10% were on some continuous medication. In the adjusted analysis, the results showed that higher levels of physical activity at 18 years and less screen time at 15 years in boys were associated with lower overall use of medicines (p < 0.05). For boys, physical activity at 11 and 18 years were inversely related to continuous medication (p < 0.05). More physically active boys and those with less screen time in adolescence showed lower use of medicines at 18 years of age. PMID:27167041

  8. Feeding of Cyphocharax voga (Hensel, 1869 (Characiformes, Curimatidae in Corrientes Stream, Pelotas, Rio Grande do Sul, Brazil

    Sergio Renato Noguez Piedras

    2008-12-01

    Full Text Available The Cyphocharax voga species is distributed from the hydrographic basin of the Paraguay River and lower Paraná up to the coastal hydrographic systems of South America. Corrientes stream sets the boundary between Turuçu and Pelotas counties and has not been a focus of detailed studies so far. The aim of this paper was to study the C. voga feeding process for a better understanding of its diet at the site. Thirty-two specimens were collected between December and March 2005, packed in ice-covered boxes and taken to the laboratory. The diet was analyzed by methods of occurrence frequency and relative frequency; for both males and females, total, average and standard deviation were registered; student's t-test and the q-square χ2 test were applied for ingested items. A total of 18 feeding categories were identified, including a 100% presence of filamentary algae and sediment. The prevalence of these items alongside with microorganisms associated with the feeding process makes this an iliophagous species in this environment. Meaningful differences in feeding between male and female specimens were not found through q-square χ2 test.

  9. Maternal anthropometric characteristics in pregnancy and blood pressure among adolescents: 1993 live birth cohort, Pelotas, southern Brazil

    Hallal Pedro C

    2010-07-01

    Full Text Available Abstract Background We investigated the association between maternal anthropometric measurements in prepregnancy and at the end of pregnancy and their children's systolic (SBP and diastolic (DBP blood pressure at 11 years of age, in a prospective cohort study. Methods All hospital births which took place in 1993 in the city of Pelotas - Brazil, were identified (5,249 live births. In 2004, the overall proportion of follow-up was 85% and we obtained arterial blood pressure measurements of 4,452 adolescents. Results Independent variables analyzed included maternal prepregnancy weight and body mass index (BMI and maternal weight, and height at the end of pregnancy. Multiple linear regression analysis controlling for the following confounders were carried out: adolescent's skin color, family income at birth, smoking, alcohol intake during pregnancy, and gestational arterial hypertension. Mean SBP and DBP were 101.9 mmHg (SD 12.3 and 63.4 mmHg (SD 9.9, respectively. Maternal prepregnancy weight and BMI, and weight at the end of pregnancy were positively associated with both SBP and DBP in adolescent subjects of both sexes; maternal height was positively associated with SBP only among males. Conclusions Adequate evaluation of maternal anthropometric characteristics during pregnancy may prevent high levels of blood pressure among adolescent children.

  10. Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

    Peres, Marco A.; Barros, Aluísio Jardim; Peres, Karen Glazer; Araújo, Cora Luiza; Menezes, Ana M. B.; Hallal, Pedro C.; Victora, Cesar G.

    2013-01-01

    The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, ranging from 0.6 (SD = 1.1) for children that were caries-free at age six, 1.3 (SD = 1.5) for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8) for those with 4-19 carious teeth at six years (p < 0.01). The number of individuals with severe malocclusions at 12 years was proportional to the number of malocclusions at six years. Oral health problems in early adolescence were more prevalent in individuals with dental problems at six years of age. PMID:20963297

  11. Nutritional status of adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Araújo, Cora Luiza; Dumith, Samuel C.; Menezes, Ana M. B.; Hallal, Pedro C.; Vieira, Maria de Fátima A.; Madruga, Samanta W.; Victora, Cesar G.

    2013-01-01

    We evaluate the influence of demographic, socioeconomic, and maternal variables on the nutritional status of adolescents aged 11 years. We conducted a prospective cohort study including 4,452 adolescents born in Pelotas, Southern Brazil, in 1993, accounting for 87.5% of the original cohort. Nutritional status was evaluated based on World Health Organization criteria. Subjects were classified according to nutritional status into thin, normal, overweight and obese. Independent variables analyzed included skin color, socioeconomic status, maternal schooling, and maternal body mass index (BMI). Analyses were stratified by sex, and multivariable regression was performed using the multinomial logistic approach. Overall, 7% of adolescents were classified as thin, 11.6% as overweight, and 11.6% as obese. Among boys, thinness was inversely associated with maternal schooling and maternal BMI. Among girls, thinness was directly associated with maternal BMI. Overweight and obesity were directly associated with socioeconomic status and maternal BMI, the former showing the strongest association with nutritional status among adolescents. PMID:20963286

  12. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study

    Salatino-Oliveira, Angélica; Murray, Joseph; Kieling, Christian; Genro, Júlia Pasqualini; Polanczyk, Guilherme; Anselmi, Luciana; Wehrmeister, Fernando; de Barros, Fernando C.; Menezes, Ana Maria Baptista; Rohde, Luis Augusto; Hutz, Mara Helena

    2016-01-01

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val158Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14–1.34; p < 0.001) at 11 years of age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09–1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. PMID:27426045

  13. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study.

    Salatino-Oliveira, Angélica; Murray, Joseph; Kieling, Christian; Genro, Júlia Pasqualini; Polanczyk, Guilherme; Anselmi, Luciana; Wehrmeister, Fernando; de Barros, Fernando C; Menezes, Ana Maria Baptista; Rohde, Luis Augusto; Hutz, Mara Helena

    2016-01-01

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14-1.34; p age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09-1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. PMID:27426045

  14. RS-84 Engine Completes Design Review

    2003-01-01

    This is an artist's concept of the kerosene-fueled RS-84 engine, one of several technologies competing to power NASA's next generation of launch vehicles. The RS-84 has successfully completed its preliminary design review as a reusable, liquid kerosene booster engine that will deliver a thrust level of 1 million pounds of force. The preliminary design review is a lengthy technical analysis that evaluates engine design according to stringent system requirements. The review ensures development is on target to meet Next Generation Launch Technology goals: Improved safety, reliability, and cost.

  15. Determinants of preterm birth: Pelotas, Rio Grande do Sul State, Brazil, 2004 birth cohort Determinantes de nascimento pré-termo na coorte de nascimentos de 2004, Pelotas, Rio Grande do Sul, Brasil

    Mariângela F. Silveira

    2010-01-01

    Full Text Available Prematurity is a leading cause of neonatal mortality and a global health problem that affects high, middle and low-income countries. Several factors may increase the risk of preterm birth. In this article, we test the hypothesis that different risk factors determine preterm birth in different income groups by investigating whether risk factors for preterm deliveries in the 2004 Pelotas (Rio Grande do Sul State, Brazil birth cohort vary among those groups. A total of 4,142 women were included in the analysis. Preterm births were equally common among women who had spontaneous vaginal deliveries as for those with induced or operative births. In the multivariate analysis the factors that remained significantly associated with preterm birth were black skin color, low education, poverty, young maternal age, primiparity, previous preterm birth, inadequacy of prenatal care and reported hypertension. In the analyses repeated after stratification by family income terciles, there was no evidence of effect modification by income and no clear difference between the socioeconomic groups. No association between cesarean section and preterm delivery was found. Further studies are required to understand the causes of the epidemic of preterm births in Brazil.A prematuridade é uma grande causa de morte neonatal e um problema de saúde global, afetando países de alta, média e baixa renda. Vários fatores podem aumentar o risco de parto pré-termo. Neste artigo, testamos a hipótese de que diferentes fatores de risco determinem o parto pré-termo em diferentes grupos de renda, investigando como fatores de risco para prematuridade na coorte de nascimentos de 2004 de Pelotas, Rio Grande do Sul, Brasil, variam entre estes grupos. Foram incluídas na análise 4.142 mulheres. Os nascimentos pretermo foram igualmente comuns entre mulheres com partos vaginais e com partos induzidos ou cesáreas. Na análise multivariada, a cor negra, baixa educação, baixa renda, idade

  16. Cobertura do exame citopatológico na cidade de Pelotas, Rio Grande do Sul, Brasil Pap test coverage in the city of Pelotas, Rio Grande do Sul, Brazil

    Juvenal Soares Dias-da-Costa

    2003-02-01

    Full Text Available No Brasil, a avaliação da efetividade de programas de prevenção e ações de saúde pública ainda são incipientes. Dessa forma, realizou-se um estudo transversal de base populacional envolvendo a saúde da população adulta residente na zona urbana da cidade de Pelotas, Rio Grande do Sul, Brasil, com o objetivo de verificar a evolução nos níveis de cobertura do exame citopatológico. Investigaram-se fatores associados com a não realização do procedimento. Considerou-se exame citopatológico atualizado aquele realizado nos últimos três anos. A amostra foi constituída por 1.122 mulheres entre 20 e 69 anos, sendo que 72,2% apresentavam exame citopatológico atualizado, 16,6% atrasado e 11,2% nunca o haviam realizado. A não realização do procedimento esteve associada com baixa inserção social e idade avançada. A regressão logística destacou o efeito independente de classe social, baixa renda familiar, idade, cor da pele, estado civil e ausência de consultas médicas no último ano. Contudo, desapareceu o efeito detectado em mulheres com doenças crônicas. Comparando-se os resultados do estudo realizado em 1992 com o atual, observa-se que a cobertura do exame aumentou de 65,0% para 72,2% (1992 para 1999/2000, entretanto, não atingiu os níveis efetivos para evitar câncer de colo uterino.In Brazil, the effectiveness of preventive public heath programs and actions is rarely evaluated. A cross-sectional study was thus performed in a population-based sample focused on several health characteristics of adults living in Pelotas, Rio Grande do Sul, Brazil. The study aimed to measure temporal trends in coverage of Pap smear testing in the city. The authors studied the factors associated with failure of women to submit to a Pap smear. An updated Pap smear was defined as one performed in the previous 3 years. The sample consisted of 1,122 women ages 20 to 69 years, 72.2% of whom had an updated Pap smear, 16.6% of whom were behind

  17. Fatores de risco para diabetes mellitus gestacional na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004 Risk factors for gestational diabetes mellitus in the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, 2004

    Maria Alice Souza de Oliveira Dode

    2009-05-01

    Full Text Available Consensos de diversos países referem idade, obesidade e história familiar de diabetes mellitus como fatores de risco para diabetes mellitus gestacional. Outros fatores permanecem controversos. O objetivo deste estudo foi investigar fatores associados ao diabetes mellitus gestacional entre mães dos recém-nascidos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, em 2004. Foram entrevistadas 4.243 puérperas no hospital, havendo 0,5% de recusas. O diagnóstico de diabetes mellitus gestacional foi auto-referido. A prevalência de diabetes mellitus gestacional foi 2,95% (IC95%: 2,53-3,64. Análise bruta realizada por meio de testes qui-quadrado mostrou associação direta com aumento da idade, escolaridade, nível econômico e índice de massa corporal (IMC e inversa com altura materna. Cor não branca, história familiar de diabetes mellitus, tabagismo no primeiro e segundo trimestres e atividade física antes da gestação e no primeiro trimestre mostraram-se associados. A análise ajustada hierarquizada realizada através de regressão logística mostrou associação com maior idade, cor não branca, maior escolaridade, história familiar de diabetes mellitus e maior IMC. A altura ficou no limiar da significância. Tabagismo no primeiro e segundo trimestres foi protetor.Consensus statements by various countries have reported age, obesity, and family history of diabetes mellitus as risk factors for gestational diabetes mellitus. Other factors remain controversial. The aim of this study was to investigate factors associated with gestational diabetes among mothers of newborns from the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, in 2004. We interviewed 4,243 postpartum women in hospital, with a 0.5% refusal rate. Diagnosis of gestational diabetes was self-reported. Prevalence of gestational diabetes was 2.95% (95%CI: 2.53-3.64. Crude analysis using the chi-square test showed a direct association with age, schooling

  18. [Poor dad, poor child? An investigation of intergenerational income mobility in the 1982 Birth Cohort in Pelotas, Rio Grande do Sul State, Brazil].

    Tejada, Cesar Augusto Oviedo; Bertoldi, Andréa D; Carraro, André; Ribeiro, Felipe Garcia; Motta, Janaína Vieira dos Santos; Barros, Fernando Celso; Horta, Bernardo Lessa; Barros, Aluísio J D

    2015-06-01

    Brazil is one of the countries with the lowest intergenerational income mobility. This article aimed to analyze intergenerational income mobility in the 1982 Birth Cohort in Pelotas, Rio Grande do Sul State. Two methods were used, intergenerational income elasticity and quantile regressions, in order to measure heterogeneity in income mobility as a function of different levels of parents' past income. The results show relatively high income mobility for Brazilian standards. The main explanation is that the data cover the children's income at a younger age (about 23 years). Quantile regressions show higher social mobility in the intermediary social stratum. The results reinforce the notion of two opposite "traps", poverty and wealth. PMID:26200370

  19. Food intake profiles of children aged 12, 24 and 48 months from the 2004 Pelotas (Brazil) birth cohort: an exploratory analysis using principal components

    Gatica Giovanna; Barros Aluisio J D; Madruga Samanta; Matijasevich Alicia; Santos Iná S

    2012-01-01

    Abstract Objectives To identify food intake profiles of children during their first four years of life and assess its variations according to sociodemographic and behavioral characteristics. Methods The Pelotas Birth Cohort Study (Brazil) recruited 4,231 liveborns, who were followed-up at ages 3, 12, 24 and 48 months. Food consumption data of children aged 12, 24 and 48 months was collected using a list of foods consumed during a 24-hour period prior to the interview. The food profiles were i...

  20. PELOTAS,“CIDADE DE GAYS”: Um estudo sobre os usos políticos de uma representação

    Gláucia Cavalheiro

    2012-09-01

    Full Text Available Esteartigo é um resumo da monografia apresentada para a conclusão do Curso de Pós-Graduação em Memória, Identidade e Cultura Material, do Instituto de Ciências Humanas da Universidade Federal de Pelotas, tendo como banca examinadora os professores Dra. Maria Letícia Mazzuchi Ferreira, Me. Edgar Rodrigues Barbosa (orientador e Dra. Flávia Rieth (co-orientadora, aos quais expresso meus profundos agradecimentos

  1. Projeto de Salvamento Arqueológico da Área Urbana de Pelotas: Praça Cel. Pedro Osório, da Casa 8 e Casa 2

    Fábio Vergara Cerqueira

    2012-09-01

    Full Text Available Este relatório  busca apresentar as atividades relativas ao projeto de salvamento arqueológico da Área Urbana de Pelotas, mais especificamente os trabalhos realizados na Praça Cel. Pedro Osório, Casa 8 e Casa 2, desenvolvidas no período de 2002 a 2004.PALAVRAS-CHAVE:  Arqueologia histórica  –  Pelotas oitocentista  – Patrimônio cultural

  2. Prevalence of enuresis and urinary symptoms at age 7 years in the 2004 birth cohort from Pelotas, Brazil

    Denise M. Mota

    2015-02-01

    Full Text Available OBJECTIVE: To determine the prevalence of enuresis, urinary, and bowel symptoms and associated factors in children aged 7 years in a birth cohort. METHODS: A pre-coded questionnaire was applied to 3,602 children who belonged to a birth cohort initiated in 2004 in Pelotas, Brazil. During home visits at 12, 24, and 48 months and at age 7 years, mothers answered a questionnaire with demographic questions and characteristics of bladder and bowel habits of children using a urinary symptom score. Poisson regression was used for the hierarchical multivariable analysis, with robust variance. RESULTS: The prevalence of enuresis was 10.6%;11.7% in males and 9.3% in females; enuresis was monosymptomatic in 9.8% of the children (10.8% of males and 8.3% of females; 37.4% had symptoms up to once a week; 32.9%, two to four times a week; and 26.2%, every day, with no difference between genders. The most common urinary symptoms were urinary urgency (22.7% and urinary retention maneuvers (38.2%. In the multivariate analysis, it was observed that the number of urinary symptoms and the number of children at home showed a direct association with the presence of enuresis, whereas maternal education was inversely associated. CONCLUSIONS: Enuresis is a prevalent condition and should be investigated in clinical practice, especially in children of lower socioeconomic status. A detailed history of urinary habits detects associated urinary symptoms, which is important for adequate classification of enuresis and subsequent management.

  3. Adesão à terapêutica da tuberculose em Pelotas, Rio Grande do Sul: na perspectiva do paciente

    Gonçalves Helen

    1999-01-01

    Full Text Available O trabalho aborda a adesão ao tratamento da tuberculose dentro do universo composto por homens e mulheres doentes e as conexões e conseqüências da doença na seu modo/fase de vida e no resultado final do tratamento. O estudo etnográfico, como um sub-estudo do Projeto Controle Epidemiológico da Tuberculose na Cidade de Pelotas, Rio Grande do Sul, propunha-se, inicialmente, verificar as razões existentes para que os pacientes não completassem o tratamento. Utilizou-se o método etnográfico de observação direta, conjugado com as entrevistas semi-estruturadas. A opção pela utilização do termo adesão é justificada pela preocupação em abranger outros fatores fundamentais, além da responsabilidade individualizada do enfermo. Esta abordagem possibilitou compreender as concepções de doença, as dinâmicas sociais entre os diversos protagonistas envolvidos no processo da doença e seu tratamento. Levaram-se em consideração alguns dos fatores implicados na adesão ao tratamento: características sócio-demográficas, fatores culturais, crenças populares, relação de custo benefício, aspectos físicos e químicos dos medicamentos, interação médico paciente e grau de participação familiar no tratamento.

  4. Freqüência das malformações múltiplas em recém-nascidos na Cidade de Pelotas, Rio Grande do Sul, Brasil, e fatores sócio-demográficos associados Frequency of multiple neonatal malformations in Pelotas, Rio Grande do Sul, Brazil, and associated socio-demographic factors

    Martha Lopes Schuch de Castro

    2006-05-01

    Full Text Available Este estudo visa determinar a freqüência, correlacionar possíveis agentes causais e monitorizar a ocorrência de malformações múltiplas na população de Pelotas, Rio Grande do Sul, Brasil. Abrange todos os nascimentos ocorridos entre 1990 e 2002 nas maternidades de Pelotas, com peso superior a 500g. Para cada recém-nascido malformado (caso, tomou-se um neonato vivo (controle, pareado a ele, sem malformação e de igual sexo. Formou-se um banco de dados mediante o preenchimento dos formulários-modelo ECLAMC ­ MONITOR edição 1982, que foram tabulados pelo programa SPSS. Para a análise estatística, utilizou-se o Teste t de Student e chi2. No período em estudo nasceram 71.500 crianças. Dentre essas, 0,11% recém-nascidos apresentaram malformações múltiplas. Foram encontrados resultados significativos para o peso, gemelaridade e nascimento, a etnia dos antepassados, a idade paterna, o número de abortos e natimortos prévios. Em Pelotas, a ocorrência de recém-nascidos que apresentavam malformações ao nascer, no período do estudo, foi de 1,37%. A freqüência de recém-nascidos com malformações múltiplas é de 8,1%, predominantemente no sexo feminino e nos nascimentos ocorridos no inverno.This study aimed to estimate the frequency and to correlate the possible causal agents and monitor the occurrence of multiple neonatal malformations in Pelotas, Rio Grande do Sul, Brazil. The study included all births from 1990 to 2002 in the local maternity hospitals with birth weight > 500g. Each newborn presenting a malformation (case was assigned a live matched neonate (control without any malformation and of the same sex. A database was established by filling out the ECLAMC ­ MONITOR forms, 1982 edition, tabulated with SPSS. Statistical analysis used Student t and chi2. During the study period, 71,500 children were born, of whom 0.11% presented multiple malformations. Significant results were found for birth weight, twin births

  5. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.

    Gao, Kaiping; Wang, Jinjin; Li, Linlin; Zhai, Yujia; Ren, Yongcheng; You, Haifei; Wang, Bingyuan; Wu, Xuli; Li, Jianna; Liu, Zichen; Li, Xiong; Huang, Yaxin; Luo, Xin-Ping; Hu, Dongsheng; Ohno, Kinji; Wang, Chongjian

    2016-03-01

    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province. PMID:26927145

  6. Roadkill of wild mammals on RS-135

    Carla Grasiele Zanin Hegel

    2012-06-01

    Full Text Available Among environmental impacts, fragmentation of habitat for agriculture and livestock has led to a distortion of the natural environment and increased rates of wildlife killed on roads. Weekly surveys of road-killed mammals were made along highway RS-135 (km 8-34 between May 2008 and May 2010. For each case, we recorded the species and location along the road. We collected 95 mammals belonging to 16 species and 12 families, with a frequency of 0.025 roadkills per kilometer. The most abundant species were Cerdocyon thous (22.11%, Nasua nasua (10.52%, Pseudalopex gymnocercus (9.47% and Cavia aperea (7.37%, which together comprised 49.5% of the cases. This study contributed with information on roadkill of wild mammals in RS-135 of Rio Grande do Sul.

  7. A diphoton resonance from bulk RS

    Csáki, Csaba; Randall, Lisa

    2016-07-01

    Recent LHC data hinted at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to any other Standard Model particles would be too low to be detected so far. Such a state has a compelling explanation in terms of a scalar or a pseudoscalar that is strongly coupled to vector states charged under the Standard Model gauge groups. Such a scenario is readily accommodated in bulk RS with a scalar localized in the bulk away from but close to the Higgs. Turning this around, we argue that a good way to find the elusive bulk RS model might be the search for a resonance with prominent couplings to gauge bosons.

  8. PADRÃO BIOMÉTRICO DOS CAVALOS DE TRAÇÃO DA CIDADE DE PELOTAS NO RIO GRANDE DO SUL

    Carlos Eduardo Wayne Nogueira

    2013-06-01

    Full Text Available Many families use wagon pulled by traction horses as their means of work or supplemental income. In Pelotas, there has been a Veterinary Clinic since 2006, which provides free weekly clinical care to these horses, due to concern about their health. The objectives of this study were to evaluate and record the biometric patterns of traction horses in Pelotas. We evaluated 219 horses, 129 females and 90 males. We measured chest width (ChW, leg perimeter (LP, thoracic perimeter (TP, croup width (CrW, height (H and weight (W of the animal. Through these values, we calculated the compactness index 1 (CCI1=(W/WH/100, compactness index 2 (CCI2 = (W/[WH-1]/100 and conformation index (CFI=TP2/WH. The animals of both sexes showed the following averages: H - 1.38 ± 0.07 m; LP - 0.19 ± 0.02 cm; TP - 1.56 ± 0.10 m; ChW - 0.26 ± 0.05 cm; CrW - 0.22 ± 0.05 cm; weight - 308 ± 60 kg. Regarding the ICC1, ICC2 and ICF indices, the averages for both sexes were, respectively: 2.30; 8.39; 1.82. Accordingly, the indices obtained showed that most of the evaluated horses were inadequate to pull heavy loads and had greater ability to pull light loads or to be used as riding horses.

  9. Association of Polymorphisms (rs 1799782, rs25489 and rs25487) in XRCC1 and (rs 13181) XPD genes with Acute Coronary Artery Syndrome in Subjects from Multan, Pakistan.

    Hameed, Hafsa; Faryal, Maemona; Aslam, Muhammad Assad; Akbar, Atif; Saad, Abu Bakar Ali; Pasha, Muhammad Burhan; Latif, Muhammad; Rehan Sadiq Shaikh, Rehan Rehan Sadiq Shaikh; Ali, Muhammad; Iqbal, Furhan

    2016-05-01

    Acute coronary artery syndrome (ACS) is the major cause of mortality in Pakistan with genetic and environmental influence on the incidence of the disease. This case-control study was designed to find out if a correlation is existing between ACS and single nucleotide polymorphisms (SNPs) in DNA repair genes XPD [at codon 751, rs 13181 (Lys to Gln)] and XRCC1 [at codon 399, rs25487 (Arg to Gln); 280, rs25489 (Arg to His) and 194, rs 1799782 (Arg to Trp)] either individually or in various combination with each other (haplotype analysis). The objective of this study was to find out the association of various studied risk factors and serum lipid profile of the subjects with the disease, if any. PCR-RFLP method was used to determine genotype at specific codon in 221 subjects (115 ACS patients and 106 healthy controls) from Southern Punjab population. Genotypic and allelic frequency distribution among the cases and controls revealed that all the studied SNPs were not individually associated with the ACS. Haplotype analysis revealed that subjects having wild type combination of all three XRCC1 SNPs had greater susceptibility to ACS than any other studied genotypic combinations. Analysis of risk factors revealed that hypertension (Peducation (Pgender (P<0.001), family history (P=0.005), smoking habit (P=0.002) and diabetes (P<0.001) were significantly associated with the incidence of ACS. Serum lipid profile analysis indicated that cholesterol level was significantly higher (P=0.048) in patients (161.5mg/dL) than controls (142.1mg/dL) while triglyceride remained unaffected (P=0.87) when compared between the two treatments. PMID:27166553

  10. Application of RS Codes in Decoding QR Code

    Zhu Suxia(朱素霞); Ji Zhenzhou; Cao Zhiyan

    2003-01-01

    The QR Code is a 2-dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents several QR Code's virtues, analyzes RS decoding algorithm and gives a software flow chart of decoding the QR Code with RS decoding algorithm.

  11. Trails, RS2477, rs2477 add roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'rs2477 add...

  12. Trails, RS2477, RS2477, Published in 2008, 1:24000 (1in=2000ft) scale, Box Elder County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'RS2477'....

  13. Novel biosensor-based microarray assay for detecting rs8099917 and rs12979860 genotypes

    Pei-Yuan Li; Xiao-Jun Zhou; Lan Yao; Xin-Hua Fang; Jiang-Nan Ren; Jia-Wu Song

    2012-01-01

    AIM:To evaluate a novel biosensor-based microarray (BBM) assay for detecting rs12979860 and rs8099917genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control probes were designed,constructed and arrayed on an optical biosensor to develop a microarray assay.Two sets of primers were used in a one tube polymerase chain reaction (PCR) system to amplify two target fragments simultaneously.The biosensor microarray contained probes that had been sequenced to confirm that they included the rsS099917C/T or rs12979860G/T alleles of interest and could serve as the specific assay standards.In addition to rehybridization of four probes of known sequence,a total of 40 clinical samples collected from hepatitis C seropositive patients were also tested.The target fragments of all 40 samples were amplified in a 50 μL PCR system.Ten μL of each amplicon was tested by BBM assay,and another 40 μL was used for sequencing.The agreement of the results obtained by the two methods was tested statistically using the kappa coefficient.The sensitivity of the BBM assay was evaluated using serial dilutions of ten clinical blood samples containing 103-104 white cells/lμL.RESULTS:As shown by polyacrylamide gel electrophoresis,two target segments of the interleukin 28B-associated polymorphisms (SNPs) were successfully amplified in the one-tube PCR system.The lengths of the two amplified fragments were consistent with the known length of the target sequences,137 and 159bps.After hybridization of the PCR amplicons with the probes located on the BBM array,the signals of each allele of both the rs8099917 SNPs and rs12979860 SNPs were observed simultaneously and were clearly visible by the unaided eye.The signals were distinct from each other,could be interpreted visually,and accurately recorded using an ordinary digital camera.To evaluate the specificity of the assay,both the plasmids and clinical samples were applied to the microarray

  14. 40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS; exemptions from the requirement of a tolerance... Tolerances § 180.1114 Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas...

  15. A novel RS BTC coding scheme for optical communications

    Yuan, Jian-guo; Jia, Yue-xing; Hu, Yun-xia

    2012-07-01

    A novel Reed Solomon (RS) block turbo code (BTC) coding scheme of RS(63,58)×RS(63,58) for optical communications is proposed. The simulation results show that the net coding gain (NCG) of this scheme at the sixth iteration is more than that of other coding schemes at the third iteration for the bit error rate (BER) of 10-12. Furthermore, the novel RS BTC has shorter component code and rapider encoding and decoding speed. Therefore, the novel RS BTC coding scheme can be better used in high-speed long-haul optical communication systems, and the novel RS BTC can be regarded as a candidate code of the super forward error correction (super-FEC) code. Moreover, the encoding/decoding design and implementation of the novel RS BTC are also presented

  16. Mass and Reliability System (MaRS)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  17. Experimental use of alcohol in early adolescence: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study Uso experimental de álcool no início da adolescência: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Noal, Ricardo B.; Ana M. B. Menezes; Cora Luiza Araújo; Hallal, Pedro C

    2010-01-01

    The aim of this study was to estimate the prevalence of experimental alcohol intake and associated factors in early adolescence. The overall sample consisted of 4,452 adolescents (mean age = 11.3 years; SD = 0.3) from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Experimental use of alcohol was reported by 17.5% of the interviewees (95%CI: 16.3-18.6), and 5% reported having tried alcohol at nine years of age or younger. Prevalence of experimental alcohol use was higher am...

  18. Imagens de humor e de política: relações entre a imprensa ilustrada e a simbologia republicana. Pelotas, 1880-1889

    Aristeu Elisandro Machado Lopes

    2009-01-01

    Nos anos 1880, a propaganda republicana começou em Pelotas com a fundação do clube e do partido republicanos. A partir daí, a propagação das atividades era constantemente noticiada nos órgãos da imprensa local. Entre eles, dois periódicos eram ilustrados e humorísticos: Cabrion (1879-1881) e A Ventarola (1887-1889). Sem descuidar da função primordial do jornal – provocar o riso do leitor através de uma apresentação humorística da realidade – esses periódicos informaram e satirizaram o process...

  19. Intake of fat and fiber-rich foods according to socioeconomic status: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Neutzling, Marilda B.; Araújo, Cora Luiza; Vieira, Maria de Fátima A.; Hallal, Pedro C.; Menezes, Ana M. B.; Victora, Cesar G.

    2013-01-01

    This study describes the food intake of adolescents participating in the 1993 birth cohort from Pelotas, Southern Brazil, according to socioeconomic position. We carried out a cross-sectional analysis of data collected in the 2004-2005 follow-up visit. Food intake in the previous year was evaluated using the Block questionnaire. Socioeconomic status was evaluated based on an assets index, divided into quintiles. Foods with the highest frequency of daily intake were white bread (83%), butter or margarine (74.6%), beans (66.4%) and milk (48.5%). Intake of butter or margarine, bread, and beans was more frequent among poorer adolescents, and the inverse was true for milk. Intake of fruits and vegetables was low in all socioeconomic strata, but particularly low among the poor. In early adolescence, all socioeconomic groups showed high consumption of foods rich in fat and low consumption of foods rich in fiber. PMID:20963287

  20. Vinte e quatro meses de heterocontrole da fluoretação das águas de abastecimento público de Pelotas, Rio Grande do Sul, Brasil

    Fábio Garcia Lima

    2004-04-01

    Full Text Available O objetivo deste estudo foi monitorar, mensalmente, os níveis de flúor na água de abastecimento público de Pelotas, Rio Grande do Sul, Brasil, bem como verificar a validade da formação de grupos de heterocontrole. Pelotas foi dividida em 16 pontos geográficos, incluindo as três Estações de Tratamento da água e a coleta foi feita de novembro de 1999 a outubro de 2001, em duplicata. Após a coleta, as amostras foram enviadas ao Laboratório de Vigilância Sanitária de Flúor da Universidade do Vale do Itajaí, onde a análise foi feita utilizando-se o método eletrométrico (Orion 920A/Eletrodo Orion 9609. Após 24 meses, 764 unidades amostrais foram coletadas e verificou-se uma inconstância nos resultados, predominando níveis insuficientes de flúor até o primeiro trimestre de 2001, quando houve um significativo aumento no número de unidades amostrais com uma concentração de flúor ideal (0,6-0,9ppmF, porém, há o surgimento de pontos revelando um excesso de fluoretos (> 1ppmF. Os resultados permitiram concluir que o heterocontrole é fundamental para buscar a manutenção de um correto programa de FAAP.

  1. El desarrollo de la investigación sobre pelota valenciana: guía bibliográfica y fuentes de información

    Gregorio González Alcaide

    2016-03-01

    Full Text Available Se presenta un estudio bibliográfico de los trabajos académicos sobre Pelota Valenciana, efectuado a partir de la consulta de las fuentes documentales de la Federació de Pilota Valenciana, del Museu de la Pilota de Genovés y de diversos catálogos y bases de datos. Se han identificado 181 trabajos, entre artículos de revistas (n = 95, publicaciones monográficas (n = 40, comunicaciones a congresos (n=37, tesis doctorales (n = 5 y obras de referencia (n = 4. Los trabajos pioneros se remontan a los años 60 y 70 del siglo xx, mientras que se observa una gran eclosión de publicaciones a partir de mediados de la década de los 80, en una tendencia que se mantiene hasta la actualidad, y que coincide con la edición de revistas especializadas, con la celebración de diferentes congresos y reuniones científicas y con la lectura de algunas tesis doctorales. Entre las materias abordadas en los trabajos, encontramos estudios históricos sobre su origen y desarrollo, investigaciones centradas en los espacios físicos en que tiene lugar el juego, en las distintas modalidades, en el vocabulario, que estudian el interés y la importancia que tiene para el ámbito educativo, análisis sociológicos y estudios médicos sobre las enfermedades relacionadas con la práctica de la pelota como actividad deportiva.

  2. Genetic Variants of VEGF (rs201963 and rs3025039) and KDR (rs7667298, rs2305948, and rs1870377) Are Associated with Glioma Risk in a Han Chinese Population: a Case-Control Study.

    Zhang, Jiannan; Yang, Jian; Chen, Yuqing; Mao, Qin; Li, Shanquan; Xiong, Wenhao; Lin, Yingying; Chen, Jie; Ge, Jianwei

    2016-05-01

    A glioma is the most common type of brain tumor that accounts for nearly 80 % of brain cancers. Vascular endothelial growth factor (VEGF) and its receptor, the kinase insert domain receptor (KDR), are involved in the angiogenesis of cancers. In this study, we investigate whether the polymorphisms of VEGF and KDR are associated with a glioma risk. Blood samples were collected from 477 glioma patients and 477 healthy controls. Five tag-single nucleotide polymorphisms (SNPs) of KDR were obtained from the HapMap database, and eight tag-SNPs of VEGF were selected based on previous studies. After extraction of genomic DNAs by a Qiagen DNA blood kit, the SNPs of VEGF and KDR were genotyped with a Sequenom MassArray iPLEX platform and further analyzed with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. The odds ratios and their 95 % confidence interval (95 % CI) were used to assess the association between VEGF, KDR polymorphisms, and glioma risks with the aid of SPSS 13.0 software. The haplotype analysis demonstrated that two SNPs of VEGF [rs3025039 (C>T), rs2010963 (G>C)] could elevate the susceptibility to a glioma in the homozygous model [odds ratio (OR) = 3.13 (95 % confidence interval (CI) 1.30-7.49, P = 0.007) and OR = 1.58 (95 % CI 1.07-2.34, P = 0.022), respectively], dominant model [OR = 1.38 (95 % CI 1.04-1.84, P = 0.025) and OR = 1.32 (95 % CI 1.01-1.72, P = 0.043), respectively], and allelic model [OR = 1.43 (95 % CI 1.11-1.84, P = 0.005) and OR = 1.24 (95 % CI 1.04-1.50, P = 0.019), respectively]. Furthermore, three SNPs of KDR [rs7667298 (A>G), rs2305948 (C>T), rs1870377 (T>A)] were also assumed to be associated with an increased risk of a glioma in the homozygous [OR = 1.93 (95 % CI 1.30-2.86, P = 0.001), OR = 2.56 (95 % CI 1.28-5.11, P = 0.006), and OR = 1.52 (95 % CI 1.00-2.31, P = 0.049), respectively], dominant [OR = 1.52 (95

  3. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China

    Gao, Kaiping; Wang, Jinjin; Li, Linlin; Zhai, Yujia; Ren, Yongcheng; You, Haifei; Wang, Bingyuan; Wu, Xuli; Li, Jianna; Liu, Zichen; Li, Xiong; Huang, Yaxin; Luo, Xin-Ping; Hu, Dongsheng; Ohno, Kinji

    2016-01-01

    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for K...

  4. Mg(2+) signalling defines the group A streptococcal CsrRS (CovRS) regulon.

    Gryllos, Ioannis; Grifantini, Renata; Colaprico, Annalisa; Jiang, Shengmei; Deforce, Emelia; Hakansson, Anders; Telford, John L; Grandi, Guido; Wessels, Michael R

    2007-08-01

    CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). Earlier studies suggested that extracellular Mg(2+) signalled through the presumed sensor histidine kinase, CsrS. We now confirm those findings, as complementation of a csrS mutant restored Mg(2+)-dependent gene regulation. Moreover, we present strong evidence that Mg(2+) signals through CsrS to regulate an extensive and previously undefined repertoire of GAS genes. The effect of Mg(2+) on regulation of global gene expression was evaluated using genomic microarrays in an M-type 3 strain of GAS and in an isogenic csrS mutant. Unexpectedly, of the 72 genes identified in the Mg(2+)-stimulated CsrRS regulon, 42 were absent from the CsrR regulon (the latter being defined by comparison of wild-type and CsrR mutant transcriptomes at low Mg(2+)). We observed CsrS-dependent regulation of 72 of the 73 genes whose expression changed in response to elevated extracellular Mg(2+) in wild-type bacteria, a result that identifies CsrS as the principal, if not exclusive, sensor for extracellular Mg(2+) in GAS. To our knowledge, this study is the first to characterize global gene regulation by a GAS two-component system in response to a specific environmental stimulus. PMID:17608796

  5. The 3Rs principle – mind the ethical gap!

    Olsson, I. Anna S.; Franco, Nuno H.; Weary, Daniel M.;

    2012-01-01

    Over the 50 years since they were first proposed, the 3Rs (Replacement, Reduction, Refinement) have made a tremendous impact. These principles seem to unify concerns for better science with causing less harm to animals. The ideas behind the 3Rs are so intuitively compelling that it is tempting to...

  6. RS-Predictor models augmented with SMARTCyp reactivities

    Zaretzki, Jed; Rydberg, Patrik; Bergeron, Charles; Bennett, Kristin P; Olsen, Lars; Breneman, Curt Mark

    2012-01-01

    RS-Predictor is a tool for creating pathway-independent, isozyme-specific site of metabolism (SOM) prediction models using any set of known cytochrome P450 substrates and metabolites. Until now, the RS-Predictor method was only trained and validated on CYP 3A4 data, but in the present study we...

  7. Configuration control plan for the ports NCS IBM RS/6000

    This document describes the actions and responsibilities for maintaining the quality and integrity of the NS software resident on the IBM RS/6000 workstation managed by the Nuclear Criticality Safety group at the Portsmouth Gaseous Diffusion Plant. This document does not address the validation of NS software packages for the RS/6000

  8. USB and RS232 voltage datalogger

    Lorenzo Hernández Tabares

    2011-01-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The design and construction of a PIC microcontroller based datalogger with USB 2.0 and RS232 interfaces is presented. The datalogger has one 0 to +10VDC analogue input, 10bits ADC, Real Time Clock, 4k sample room on the microcontroller’s program flash memory and an external DC power supply. This paper proposes a cheap variant to construct such device widely used in meteorological and environmental instrumentation among others. The prototype was attached to an Ultraviolet Photometric O3 Analyzer for recording the environmental (tropospheric ozone concentration in a control station at the Havana city. Key words: datalogger, USB, enviromental ozone

  9. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil Determinants and patterns of bicycle use and traffic accidents among bicycling workers in Pelotas, Rio Grande do Sul, Brazil

    Giancarlo Bacchieri

    2005-10-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.A population-based cross-sectional study was conducted in Pelotas, southern Brazil, focusing on the determinants and patterns of bicycle use as a mode of commuting by workers. Accidents during commuting and use of safety equipment were also studied. The sample included 1,705 workers (> 15 years of age living in the urban area of Pelotas and using various modes of transportation during commuting. Crude and adjusted analyses were performed using Poisson regression, taking the design effect into account. Prevalence of bicycle use was 17.2% (95%CI: 15.4%-19.0%. Male workers and those with low schooling and low income presented higher prevalence. Less than 1.0% of the bicycles featured the safety equipment

  10. Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma.

    Pan, Wenting; Cheng, Guangxia; Xing, Huaixin; Shi, Juan; Lu, Chao; Wei, Jinyu; Li, Lichao; Zhou, Changchun; Yuan, Qipeng; Zhou, Liqing; Yang, Ming

    2014-01-01

    Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both PHCC cases and 1954 controls), we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P = 1.6×10(-6)). Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P = 3.3×10(-6)). A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population. PMID:25365256

  11. Frequency of rs731236 (Taql, rs2228570 (Fok1 of Vitamin-D Receptor (VDR gene in Emirati healthy population

    Enas Osman

    2015-12-01

    Full Text Available Vitamin D is getting more attention everyday due to its importance in maintaining bone and calcium homeostasis, cellular proliferation, differentiation and immune response. Vitamin D is derived from diet or elicited in the skin by the activation of 7-dehydrocholesterol, which is an inert molecule that must be activated by ultraviolet light to form pre-vitamin D3. Recent studies connected the gene encoding for vitamin D (VDR to the genetic control of bone mass and other diseases. As VDR SNPs have been associated with several disorders and diseases, it's important to investigate the allelic and genotypic distribution among populations. The aim of this study is to determine the frequency of rs731236 (Taq1 and rs2228570 (Fok1 variants in healthy Emirati individuals and compare their genotype and allele distribution with other populations. In this study 282 (female, 187; male, 95 unrelated healthy UAE nationals were involved. Two hundreds and eight two DNA samples been collected to genotype rs731236 (Taq1 and rs2228570 (Fok1 VDR SNPs. Our results indicate that the distribution of the alleles and genotypes of rs731236 (Taq1 and rs2228570 (Fok1 vary considerably in different populations. In the Emirati population the distribution of rs731236 (Taq1 and rs2228570 (Fok1 were AA 38%, AG 42%, GG 20% and AA 27%, AG 42%, GG 31% respectively. The Emirati population genotype and allele distribution of rs731236 (Taq1 and rs2228570 (Fok1 had no difference with Caucasians from USA and France. However, there was significant difference with Asian populations.

  12. Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma.

    Wenting Pan

    Full Text Available Recent genome-wide association studies (GWAS have identified eleven leukocyte telomere length (LTL-related single nucleotide polymorphisms (SNPs. Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV-related hepatocellular carcinoma (HCC, we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P<0.005 after Bonferroni corrections. There was no significant difference of either rs621559 or rs398652 genotypes between chronic HBV carriers and healthy controls, demonstrating that the association was not due to predisposition to HBV infection. In the pooled analyses (1806 HBV-related HCC cases and 1954 controls, we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P = 1.6×10(-6. Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P = 3.3×10(-6. A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population.

  13. Abundância e flutuação populacional das espécies de Chrysomya (Diptera, Calliphoridae em Pelotas, Rio Grande do Sul, Brasil Abundance and populational fluctuation of Chrysomya (Diptera, Calliphoridae species, in Pelotas, Rio Grande do Sul, Brazil

    Élvia E. S. Vianna

    2004-09-01

    Full Text Available To estimate the populational fluctuation of Chrysomya Robineau-Desvoidy, 1830 species and the relation of populational abundance around, six wind oriented trap (WOT were placed in three distinct ecological areas (urban, rural and wild in Pelotas, Rio Grande do Sul, Brazil, from February/1993 to January/1995. The flies were weekly collected. Captured species were Chrysomya albiceps Wiedmann, 1819, C. megacephala Fabricius, 1794 and C. putoria Wiedmann, 1830 with respective abundance of 64.5%, 19.7% and 0.9%, representing a total of 85.0% of 409,920 specimens of Calliphoridae. The three species demonstrated similarity in the populational fluctuation, except in the abundance. The populational peak ocurred in autum when the temperature decreases. In the months of July to November no fly was collected, recomposing the population in December, when the temperature surpassed 20ºC.

  14. RS-34 Phoenix (Peacekeeper Post Boost Propulsion System) Utilization Study

    Esther, Elizabeth A.; Kos, Larry; Bruno, Cy

    2012-01-01

    The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) in conjunction with Pratt & Whitney Rocketdyne conducted a study to evaluate potential in-space applications for the Rocketdyne produced RS-34 propulsion system. The existing RS-34 propulsion system is a remaining asset from the decommissioned United States Air Force Peacekeeper ICBM program; specifically the pressure-fed storable bipropellant Stage IV Post Boost Propulsion System, renamed Phoenix. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in October 2009. RS-34 propulsion system components were harvested from stages supplied by the USAF and used on the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC is working closely with the USAF to obtain all the remaining RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Phoenix Utilization Study sought to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions: 1) small satellite delivery (SSD), 2) orbital debris removal (ODR), 3) ISS re-supply, 4) SLS kick stage, 5) manned GEO servicing precursor mission, and an Earth-Moon L-2 Waypoint mission. The small satellite delivery and orbital debris removal missions were found to closely mimic the heritage RS-34 mission. It is believed that this technology will enable a small, low-cost multiple satellite delivery to multiple orbital locations with a single

  15. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

    James Cheng-Chung Wei

    Full Text Available Ankylosing spondylitis (AS is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569 and within ANO6 at 12q12 (rs17095830 contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G and AS complications (uveitis and inflammatory bowel disease were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.

  16. Imagens de humor e de política: relações entre a imprensa ilustrada e a simbologia republicana. Pelotas, 1880-1889

    Aristeu Elisandro Machado Lopes

    2009-04-01

    Full Text Available Nos anos 1880, a propaganda republicana começou em Pelotas com a fundação do clube e do partido republicanos. A partir daí, a propagação das atividades era constantemente noticiada nos órgãos da imprensa local. Entre eles, dois periódicos eram ilustrados e humorísticos: Cabrion (1879-1881 e A Ventarola (1887-1889. Sem descuidar da função primordial do jornal – provocar o riso do leitor através de uma apresentação humorística da realidade – esses periódicos informaram e satirizaram o processo republicano. Este artigo busca analisar a vinculação entre esses periódicos e a questão republicana durante as atividades de propaganda e, especificamente, como ocorreu o emprego da simbologia republicana na elaboração das ilustrações.

  17. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil

    Giana da Silveira Lima

    2008-12-01

    Full Text Available Despite the large number of published cases about oral and maxillofacial pediatric lesions, the literature is scarce on epidemiological studies regarding the prevalence of these entities. This study retrieved oral and maxillofacial pediatric lesions from the Center of Diagnosis of Oral Diseases (CDDB at the Dental School of the Federal University of Pelotas (UFPEL, comprising a 20-year period (1983-2002. From the total of 9,465 biopsies received in this period, 625 (6.6% were from children aged 0 to 14 years. Regardless of the histopathological diagnosis, patient data referring to lesion location, sex and age were collected. Diagnoses were grouped in 13 categories. As much as 89% of the cases occurred in patients aged 7 to 14 years (53% in females and 47% in males. Mucocele (17.2% was the most common type of lesion, followed by dentigerous cyst (8.6%. In the category of odontogenic tumors, odontoma was the most frequent lesion (64.2%. Malignant lesions were observed in a small section of the sample (1.2%. Generally, the results of the present study are in line with those reported in the literature concerning the most prevalent lesions in the pediatric population. Most lesions were benign, and malignant lesions were diagnosed in a very small part of the sample.

  18. Concurrent determinants of blood pressure among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Menezes, Ana M. B.; Hallal, Pedro C.; Araújo, Cora Luiza; Barros, Fernando C.; Victora, Cesar G.

    2013-01-01

    The aim of this study was to evaluate concurrent risk factors for high blood pressure in adolescents. This is a prospective cohort study including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil, in 1993. Blood pressure was measured before and after the interview, and the mean value was used in the analyses. Mean systolic blood pressure was 101.9mmHg (SD = 12.3) and mean diastolic pressure was 63.4mmHg (SD = 9.9). Adolescents with black skin had higher blood pressure than those with white skin. Mean systolic pressure among subjects in the top quartile of body mass index (BMI) was 11.6mmHg higher than among those in the lowest quartile. Mean systolic pressure among postmenarcheal girls was 5.4mmHg higher than among premenarcheal girls. Similar trends were found for diastolic arterial pressure. Our findings suggest that blood pressure control must begin already in childhood and adolescence. PMID:20963295

  19. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil.

    Lima, Giana da Silveira; Fontes, Silvia Terra; de Araújo, Lenita Maria Aver; Etges, Adriana; Tarquinio, Sandra Beatriz Chaves; Gomes, Ana Paula Neutzling

    2008-01-01

    Despite the large number of published cases about oral and maxillofacial pediatric lesions, the literature is scarce on epidemiological studies regarding the prevalence of these entities. This study retrieved oral and maxillofacial pediatric lesions from the Center of Diagnosis of Oral Diseases (CDDB) at the Dental School of the Federal University of Pelotas (UFPEL), comprising a 20-year period (1983-2002). From the total of 9,465 biopsies received in this period, 625 (6.6%) were from children aged 0 to 14 years. Regardless of the histopathological diagnosis, patient data referring to lesion location, sex and age were collected. Diagnoses were grouped in 13 categories. As much as 89% of the cases occurred in patients aged 7 to 14 years (53% in females and 47% in males). Mucocele (17.2%) was the most common type of lesion, followed by dentigerous cyst (8.6%). In the category of odontogenic tumors, odontoma was the most frequent lesion (64.2%). Malignant lesions were observed in a small section of the sample (1.2%). Generally, the results of the present study are in line with those reported in the literature concerning the most prevalent lesions in the pediatric population. Most lesions were benign, and malignant lesions were diagnosed in a very small part of the sample. PMID:19082398

  20. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  1. Uso da bola suíça no trabalho de parto Uso de la pelota suiza en el trabajo de parto Using the Swiss ball in labor

    Lia Mota e Silva

    2011-01-01

    Full Text Available OBJETIVOS: Caracterizar o uso da bola suíça na assistência à parturiente em serviços de atenção obstétrica vinculado ao Sistema Único de Saúde no Município de São Paulo e identificar as características de seu emprego na assistência à parturiente por enfermeira obstétricas. MÉTODOS: Estudo descritivo com base em entrevistas estruturadas com 35 enfermeiras que prestavam assistência às parturientes. RESULTADOS: Constatou-se que 100% dos Centros de Parto Normal e 40,9% dos Centros Obstétricos possuiam bola suíça. As indicações do uso da bola suíça foram: promover a descida da apresentação fetal (32,4%, relaxamento (19,7%, progressão do parto (17,1%, exercício do períneo (14,5%, alívio da dor (11,8%, benefícios psicológicos e movimentação materna. A quase totalidade das instituições visitadas (96,8% não possuia protocolo para sua utilização. CONCLUSÃO: O estudo apontou que as enfermeiras atribuem benefícios ao uso da bola suíça no trabalho de parto. Ensaios clínicos são necessários para avaliar seus efeitos e subsidiar a elaboração de orientações para seu uso.OBJETIVOS: Caracterizar el uso de la pelota suiza en la asistencia a la parturienta en servicios de atención obstétrica vinculado al Sistema Único de Salud en el Municipio de Sao Paulo e identificar las características de su empleo en la asistencia de la parturienta por enfermeras obstétricas. MÉTODOS: Estudio descriptivo a partir de entrevistas estructuradas realizadas a 35 enfermeras que prestaban asistencia a las parturientas. RESULTADOS: Se constató que el 100% de los Centros de Parto Normal y 40,9% de los Centros Obstétricos poseían la pelota suiza. Las indicaciones del uso de la pelota suiza fueron: promover el descenso de la presentación fetal (32,4%, relajamiento (19,7%, progresión del parto (17,1%, ejercicio del periné (14,5%, alivio del dolor (11,8%, beneficios psicológicos y movimiento materno. La casi totalidad de las

  2. Distúrbios menstruais entre mulheres de 15-54 anos de idade em Pelotas, Rio Grande do Sul, Brasil: estudo de base populacional

    Raquel Siqueira Barcelos

    2013-11-01

    Full Text Available Para avaliar a prevalência de distúrbios menstruais e sua distribuição conforme paridade e características demográficas, sociais e comportamentais, entre 15-54 anos de idade, realizou-se estudo transversal de base populacional, em Pelotas, Rio Grande do Sul, Brasil, com 1.078 mulheres. Foram investigados sangramento menstrual excessivo, sangramento intermenstrual, ciclo menstrual curto, ciclo menstrual longo e menstruação prolongada. Foram calculadas as taxas de prevalência, com intervalos de 95% de confiança. A prevalência global de distúrbios menstruais foi 46,4% (43,4-49,4. O mais prevalente foi sangramento menstrual excessivo (23,2%; 20,5-25,8, seguido de ciclo menstrual curto (19,2%; 16,6-21,8, ciclo menstrual longo (14,8%; 12,7-16,9, sangramento intermenstrual (11,1%; 9,1-13,2 e menstruação prolongada (7,9%; 6,3-9,4. Os distúrbios menstruais são frequentes na população, estando associados à idade maior que 34 anos, escolaridade menor que cinco anos, maior paridade, laqueadura tubária e tabagismo.

  3. IZOBRAŽEVANJE SVETOVALCEV ZAPOSLITVE NA ZAVODU RS ZA ZAPOSLOVANJE

    Kozamernik, Neva

    2010-01-01

    Diplomsko delo obravnava vlogo in pomen izobraževanja svetovalcev zaposlitve na Zavodu RS za zaposlovanje na Območni enoti Ljubljana v povezavi s svetovanjem in pomočjo brezposelnim osebam. Kajti spremembe zunanjega okolja

  4. Trails, RS2477, centerlines83, Published in 2008, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2008. It is described as 'centerlines83'. Data by this publisher are often...

  5. Trails, RS2477, wintqutrs, Published in 2008, Carbon County GIS.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Field Survey/GPS information as of 2008. It is described as 'wintqutrs'. Data by this publisher are...

  6. Trails, RS2477, picpts, Published in 2006, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts'. Data by this publisher are often provided...

  7. Trails, RS2477, 34b, Published in 2006, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as '34b'. Data by this publisher are often provided in...

  8. Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population.

    Orenay-Boyacioglu, Seda; Coskunoglu, Aysun; Caki, Zerrin; Cam, Fethi Sirri

    2016-08-01

    Glial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the inner ear. However, the auditory pathway studies of GDNF gene polymorphisms are scarce in the literature, and the studies especially associated with tinnitus are limited. Our study aimed to identify whether GDNF gene polymorphisms play any roles in the pathophysiology of tinnitus by investigating the relationship between tinnitus and GDNF polymorphisms. A total of 52 patients with chronic tinnitus and ages ranging from 18 to 55 were admitted to the Ear-Nose-Throat outpatient clinic of Celal Bayar University Medical Faculty Hospital of Manisa, Turkey and constituted the study group. Another 42 patients of the same age range, without tinnitus symptoms and lacking any systemic disease, were also admitted to the clinic and formed the control group. The tympanometric, audiological, and psychoacoustic assessments of the subjects were performed. Deoxyribonucleic acid samples obtained using venous blood taken for routine inspections were used to investigate GDNF gene polymorphisms (rs884344, rs3812047, and rs1110149) by polymerase chain reaction-based restriction fragment length polymorphism method. No correlation could be detected between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus (p > 0.05). Heterozygosity was significantly lower for GDNF rs1110149 polymorphism in tinnitus subjects compared to the controls (p tinnitus and control groups (p > 0.05). Failure to detect correlations between tinnitus and GDNF gene polymorphisms suggests this may be due to the fact that the GDNF gene has a variable expression pattern in different tissues and pathologies. Therefore, the study should be improved and its scope should be expanded by including a larger group of patients and different tissues to investigate the expression pattern of GDNF. PMID:27180191

  9. Improving Reliability of Communication in RS-485 Design

    蒋小平; 刘晓辉

    2002-01-01

    Three aspects of RS-485 application, which affect the reliability of communication of data system are analyzed and discussed. In network configuration, it presents the optimal configuration for the bus of RS-485, the better rule for derivative line and the choice for termination. In hardware design, it presents three parts of driver's peripheral circuit. In control software design, it presents a method of using 75176's DE line to control the driver.

  10. Have the 3Rs and alternatives been effectively explored?

    Adrian Smith

    2015-01-01

    Although the concept of the 3Rs was developed in the 1950s, it took many years before it became a central theme when planning and conducting experiments which might involve animals.There are still many ways in which protocols can be im-proved to increase both animal welfare and the reliability of the scientific data obtained from the studies. This paper gives some practical advice on how the 3Rs can be implemented more thoroughly in animal research.

  11. The optimal algorithm for Multi-source RS image fusion.

    Fu, Wei; Huang, Shui-Guang; Li, Zeng-Shun; Shen, Hao; Li, Jun-Shuai; Wang, Peng-Yuan

    2016-01-01

    In order to solve the issue which the fusion rules cannot be self-adaptively adjusted by using available fusion methods according to the subsequent processing requirements of Remote Sensing (RS) image, this paper puts forward GSDA (genetic-iterative self-organizing data analysis algorithm) by integrating the merit of genetic arithmetic together with the advantage of iterative self-organizing data analysis algorithm for multi-source RS image fusion. The proposed algorithm considers the wavelet transform of the translation invariance as the model operator, also regards the contrast pyramid conversion as the observed operator. The algorithm then designs the objective function by taking use of the weighted sum of evaluation indices, and optimizes the objective function by employing GSDA so as to get a higher resolution of RS image. As discussed above, the bullet points of the text are summarized as follows.•The contribution proposes the iterative self-organizing data analysis algorithm for multi-source RS image fusion.•This article presents GSDA algorithm for the self-adaptively adjustment of the fusion rules.•This text comes up with the model operator and the observed operator as the fusion scheme of RS image based on GSDA. The proposed algorithm opens up a novel algorithmic pathway for multi-source RS image fusion by means of GSDA. PMID:27408827

  12. Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models.

    He, Caiyun; Xu, Qian; Tu, Huakang; Sun, Liping; Gong, Yuehua; Liu, Jingwei; Yuan, Yuan

    2016-05-01

    The pepsinogen C (PGC) gene encodes a major differentiation biomarker for gastric mucosa and has two single nucleotide polymorphisms, rs9471643 G>C and rs6458238 G>A, within its 5' upstream region that are involved in gastric carcinogenesis. However, in what genetic models the two polymorphisms modulate disease risk and how they relate to gastric carcinogenesis needs further study. We fitted the most appropriate genetic models to the PGC polymorphisms and validated their robustness; then with knowledge of the genetic model, we investigated the influence of functional variant alleles or genotypes on gene expression in vitro and in vivo. We confirmed that rs9471643 CG genotype was stably associated with reduced gastric cancer risk in complete overdominant model. This favorable CG genotype was also associated with reduced atrophic gastritis risk in subjects carrying rs6458238 AG/AA genotype. The G>C transition at rs9471643 enhanced promoter activity and transcription factor binding ability, and the CG genotype was consistently associated with elevated levels of PGC mRNA, in situ protein and serum protein in complete overdominant model based-analyses. Additionally, rs6458238 AG/AA genotype was associated with reduced atrophic gastritis risk in dominant model. Its favorable A allele was related to higher promoter activity and lower transcription factor binding ability, and the AG/AA genotype showed association with elevated levels of serum PGC protein in dominant model based-analyses. Our results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer. © 2015 Wiley Periodicals, Inc. PMID:25857852

  13. Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide

    Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 °C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1–4 and 20 % of loaded PB released from the nanocarriers within 100 h

  14. Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide

    Hoobakht, Fatemeh; Ganji, Fariba, E-mail: fganji@modares.ac.ir; Vasheghani-Farahani, Ebrahim [Tarbiat Modares University, Biomedical Engineering Group, Chemical Engineering Department (Iran, Islamic Republic of); Mousavi, Seyyed Mohammad [Tarbiat Modares University, Biotechnology Group, Chemical Engineering Department (Iran, Islamic Republic of)

    2013-09-15

    Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 Degree-Sign C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1-4 and 20 % of loaded PB released from the nanocarriers within 100 h.

  15. Maternal smoking in successive pregnancies and recurrence of low birthweight: the 2004 Pelotas birth cohort study, Brazil Tabaquismo materno en sucesivas gestaciones y recurrencia de bajo peso al nacer: cohorte de nacimientos de Pelotas, Río Grande do Sul, Brasil, 2004 Tabagismo materno em sucessivas gestações e recorrência de baixo peso ao nascer: coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004

    Iândora Krolow Timm Sclowitz

    2013-01-01

    Full Text Available To evaluate the frequency of maternal smoking in successive pregnancies and its association with repetition of low birthweight, a study was conducted of a subsample of mothers from the 2004 Pelotas Birth Cohort in Brazil. Only women with previous histories of low birthweight newborns were included. Women with ≥ 2 previous births were eligible only if at least one of the two births immediately preceding the 2004 birth had low birthweight. From 4,458 births, 565 were included in this study. Frequency of smoking was 32.4%. Considering past pregnancies, 67.1% of mothers never smoked, 21.4% smoked during all pregnancies, 6.5% were ex-smokers, and 5% smoked only during the current pregnancy. In the adjusted analyses, when compared to mothers who never smoked, those who smoked during all pregnancies had 2.5 times greater probability of low birthweight recurrence in 2004 (PR = 2.5; 95%CI: 1.32-4.80. Smoking persistence is an important factor for the recurrence of low birthweight in successive pregnancies.Este estudio fue realizado en una submuestra de madres de la cohorte de nacimientos de Pelotas, Río Grande do Sul, Brasil, de 2004 para evaluar la frecuencia y asociación del tabaquismo en sucesivas gestaciones con el fenómeno de repetición del bajo peso al nacer. Se incluyeron solamente mujeres con antecedentes en el historial médico de recién nacidos con bajo peso al nacer. Se elegían a mujeres con ≥ 2 partos anteriores, solamente, si por lo menos uno de los dos partos inmediatamente anteriores al de 2004 hubiera sido de bajo peso al nacer. De los 4.458 nacimientos, 565 fueron incluidos en la muestra. La frecuencia de tabaquismo fue de un 32,4% y, teniendo en consideración las gestaciones anteriores, un 67,1% nunca fumaron; un 21,4% siempre fumaron; un 6,5% eran ex-fumadoras; y un 5,0% fumaron solamente en la gestación actual. En el análisis multivariable, las madres que fumaron en todas las gestaciones tuvieron una probabilidad 2

  16. Óbitos infantis evitáveis nas coortes de nascimentos de Pelotas, Rio Grandedo Sul, Brasil, de 1993 e 2004

    Iná S. Santos

    2014-11-01

    Full Text Available Comparou-se a mortalidade infantil por causas evitáveis (óbitos reduzíveis por ações de imunoprevenção; por adequada atenção à mulher na gestação e parto e ao recém-nascido; por ações adequadas de diagnóstico e tratamento; e por ações adequadas de promoção à saúde vinculadas às ações adequadas de atenção à saúde nas coortes de nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 1993 e 2004. Os óbitos foram monitorizados mediante visitas aos hospitais, cartórios, cemitérios, Delegacia Regional de Saúde e rastreio à base de dados do Sistema de Informações sobre Mortalidade (SIM do Rio Grande do Sul. Na coorte de 1993, houve 5.249 nascidos vivos e 111 óbitos infantis; na de 2004, 4.231 nascidos vivos e 82 óbitos infantis. O coeficiente de mortalidade infantil evitável foi 15,2:1.000 nascidos vivos em 1993 e 15,4 em 2004. Os coeficientes de mortalidades neonatal e pós-neonatal evitáveis foram, respectivamente, 11,2 e 4,0 em 1993 e 10,9 e 4,5 em 2004. Estratégias que visem à prevenção da prematuridade poderão ajudar a reduzir a mortalidade infantil em nosso meio.

  17. The Tutorial Education Program on the Formation of the New Milenium's Meteorologist: 20 Years of Project Experience at Universidade Federal de Pelotas - Brazil

    Foster, P.

    2012-12-01

    The Programa de Educação Tutorial (Tutorial Education Program), also known as "PET", has the objective to finance students with potential, encouraging and providing extracurricular activities in order to promote the integration with the academic market and the development of study programs in graduate school, preparing a professional that in the future will operate in a global market, transforming and fighting for the professional interests of their class. The design of the program dates back to 1970 and is based on the model of learning and guidance to form the student. The groups are composed gradually, through an annual selection. The deployment and implementation of the groups consider the inclusion of new members in different stages of their school program, working in an integrated manner. To apply, students must submit satisfactory academic performance, without failures on any course and commit to devote a minimum of twenty hours per week to the program activities. Deployed at Universidade Federal de Pelotas - Brazil, in 1991, the group has contributed to the training of students of Meteorology through the concept of teaching-research-extension activities. We believe that PET has been of utmost importance in the training of the new millennium's professional, given that the objectives of this program seek to provide an excellent level of academic training to undergraduates, encouraging their entry into the graduate studies; stimulating the improvement of the quality of teaching degree through the development of new practices and teaching experience; multiplying the activities developed by scholars and increase their interactions with program's faculty and other students of the institution. With the highly competitive market requiring specialized professionals, the high investment in students with potential can be reversed for the benefit of the profession.

  18. Dietary assessment in the 1993 Pelotas (Brazil birth cohort study: comparing energy intake with energy expenditure Avaliação dietética da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: uma comparação da ingestão e do gasto de energia

    Denise P. Gigante

    2010-11-01

    Full Text Available The study aims to describe and compare two methods of energy intake assessment and one measure of energy expenditure applied in adolescents from a birth cohort. In a sub-sample of the 1993 Pelotas (Brazil birth cohort, followed up in 2006-7, information on intake was obtained through a food-frequency questionnaire (FFQ and three 24-hour-recalls (24hR, while energy expenditure was assessed using an accelerometer. Bland & Altman plots were used in the analyses in order to compare the methods. The mean difference between FFQ and 24hR was 592 ± 929cal/day. Compared to energy expenditure, intake was overestimated when measured by FFQ (357 ± 968cal/day and underestimated by 24hR (-278 ± 714cal/day. In spite of the great differences between energy intake obtained using the two methods, lower differences were observed when these methods were compared to expenditure.O objetivo do estudo foi descrever e comparar dois métodos de avaliação de consumo calórico e uma medida de gasto energético aplicados em adolescentes de uma coorte de nascimentos. Em uma subamostra da coorte de 1993 de Pelotas, Rio Grande do Sul, Brasil, acompanhada em 2006-2007, informações sobre consumo calórico foram obtidas através de questionário de frequência alimentar (QFA e três recordatórios de 24 horas (R24h, enquanto gasto energético foi avaliado por acelerômetro. Gráficos de Bland & Altman foram usados na comparação dos métodos. A diferença média entre QFA e R24h foi 592 ± 929cal/dia. Ao comparar com gasto energético, o consumo foi superestimado se medido pelo QFA (357 ± 968cal/dia e subestimado pelo R24h (-278 ± 714cal/dia. Apesar da grande diferença no consumo, menores diferenças foram observadas quando os dois métodos foram comparados ao gasto energético.

  19. Self-reporting versus parental reporting of physical activity in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Auto-relato de atividade física na adolescência comparado ao relato dos pais: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Felipe F. Reichert

    2010-10-01

    Full Text Available The aim of this study was to verify the agreement between different approaches for estimating levels of physical activity in adolescents. One questionnaire was administered to parents and two were administered to the adolescents. This was a cross-sectional analysis of data collected in the 2004-2005 follow-up of the 1993 Pelotas (Brazil birth cohort study. Parents or guardians answered the following question: "Compared to most children the same age, would you say that your child exercises more, less, or the same amount?" A similar question was addressed to adolescents, as was a detailed questionnaire on physical activity. Agreement between the questionnaires was measured by the weighted kappa statistic. A total of 4,254 adolescents and parents/guardians answered the questionnaires. Kappa values indicated low agreement for all comparisons (kappa O objetivo deste estudo foi verificar a concordância entre diferentes formas de se estimar o nível de atividade física de adolescentes. Um questionário foi aplicado aos pais e outros dois aos adolescentes. O estudo foi transversal aninhado ao acompanhamento de 2004-2005 da coorte de nascimentos de 1993 em Pelotas, Rio Grande do Sul, Brasil. Pais ou responsáveis responderam à questão: "Comparando com a maioria das crianças da mesma idade, o(a Sr(a. diria que o seu filho faz mais exercícios que elas, menos exercícios que elas ou a mesma quantidade que elas?". Questão análoga foi aplicada aos adolescentes. Os adolescentes também responderam a um questionário mais detalhado sobre a prática de atividades físicas. A concordância entre os questionários foi avaliada pelo teste kappa ponderado. Um total de 4.254 adolescentes e responsáveis responderam aos questionários. Os valores de kappa indicaram concordância baixa para quaisquer das comparações (kappa < 0,33 para todas as análises. A mensuração de atividade física em adolescentes é complexa e os instrumentos disponíveis devem ser

  20. Sedentary behavior in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Comportamento sedentário em adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Samuel C. Dumith

    2010-10-01

    Full Text Available The aim of this study was to estimate the prevalence of sedentary behavior and investigate associated factors in adolescents 11 years of age from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Sedentary behavior was investigated with a questionnaire, and was defined as spending more than two hours per day watching television, playing videogames, or using the computer. Of the 4,452 adolescents interviewed, 98% reported watching television, 44% playing videogames, and 22% using the computer. The average time spent on each of these electronic media was 197, 36, and 17 minutes per day, respectively. Prevalence of sedentary behavior was 79.7% (95%CI: 78.6; 80.9 and showed a positive association with socioeconomic level and nutritional status and a negative association with well-being. These 11-year-olds spent extensive time at TV viewing, videogames, and the computer. Special attention should be given to the most exposed groups of adolescents, including the more affluent, overweight, and those with limited schooling.O objetivo deste estudo foi determinar a prevalência e investigar os fatores associados ao comportamento sedentário em adolescentes de 11 anos, pertencentes à coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil. O comportamento sedentário foi coletado por meio de questionário, e definido como ficar mais de duas horas por dia assistindo à televisão, jogando videogame ou usando computador. Dos 4.452 adolescentes entrevistados, 98% assistiam à televisão, 44% jogavam videogame e 22% usavam computador. O tempo médio na frente de cada um desses meios eletrônicos foi, respectivamente, 197, 36 e 17 minutos por dia. A prevalência de comportamento sedentário foi de 79,7% (IC95%: 78,6; 80,9, e teve uma associação positiva com nível socioeconômico e com estado nutricional, e negativa com a escala de bem-estar. O tempo despendido em atividades como ver televisão, jogar videogame e usar computador

  1. Oral health studies in the 1982 Pelotas (Brazil birth cohort: methodology and principal results at 15 and 24 years of age Estudo longitudinal de saúde bucal na coorte de nascidos vivos em Pelotas, Rio Grande do Sul, Brasil, 1982: aspectos metodológicos e resultados principais aos 15 e 24 anos de idade

    Karen Glazer Peres

    2011-08-01

    Full Text Available The aim of this study was to describe the methodology and results of oral health studies nested in a birth cohort in Pelotas, Southern Brazil. For the oral health studies a sub-sample (n = 900 was selected from the cohort and dental examinations and interviews were performed at ages 15 (n = 888 and 24 years (n = 720; 81.1%. Data collection included dental outcomes, dental care, oral health behaviors, and use of dental services. Mean DMF-T varied from 5.1 (SD = 3.8 to 5.6 (SD = 4.1 in the study period. The proportion of individuals with at least one filled tooth increased from 51.9% to more than 70%. Individuals who had always been poor used dental services less and had fewer healthy teeth on average than those who had never been poor. Individuals with decreasing or increasing family income trajectories showed intermediate values. An increase was seen in the number of healthy teeth from age 15 to 24 only among those who had never been poor. A history of at least one experience with poverty had a negative impact on oral health in adulthood.Descreveu-se a metodologia e os resultados dos estudos de saúde bucal em uma coorte de nascimentos. Em 1997, uma amostra da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, (n = 900 foi sorteada para o estudo de saúde bucal (15 anos e os mesmos indivíduos foram novamente investigados aos 24 anos. Agravos bucais, cuidados com a saúde bucal e uso de serviços odontológicos foram avaliados. Participaram do estudo 888 adolescentes aos 15 anos e 720 (81,1% aos 24. O índice CPO-D médio variou de 5,1 (DP = 3,8 a 5,6 (DP = 4,1 no período. Ter pelo menos um dente restaurado passou de 51,9% aos 15 anos para mais de 70% aos 24. A proporção do uso de serviços e a média de dentes saudáveis foram menores dentre os sempre pobres quando comparados àqueles nunca pobres. Indivíduos com trajetórias econômicas descendente ou ascendente tiveram valores intermediários. Aumento de dentes saudáveis dos 15

  2. Avaliação do processo da atenção médica: adequação do tratamento de pacientes com diabetes mellitus, Pelotas, Rio Grande do Sul, Brasil Clinical management of diabetic patients: process evaluation in Pelotas, Southern Brazil

    Maria Cecília Formoso Assunção

    2002-02-01

    Full Text Available Com objetivo de avaliar a adequação do manejo de pacientes diabéticos, durante o ano de 1998 foram entrevistados, em domicílio, pacientes atendidos nos postos de saúde da zona urbana de Pelotas, Rio Grande do Sul, Brasil. Coletaram-se informações relativas a características da doença e do tratamento dos mesmos. Analisou-se o tratamento do diabetes mellitus em três componentes: realização de dieta, atividade física e tratamento medicamentoso. Verificou-se que 76% dos entrevistados receberam orientações dietéticas; porém, apenas metade desses as seguiram nos últimos quinze dias. Dos 75% dos pacientes que receberam orientações sobre exercícios físicos, apenas um terço praticou algum tipo de atividade no último mês. Dos 377 entrevistados, 289 (77% utilizavam algum tipo de medicamento. Grande parte dos usuários de hipoglicemiantes orais apresentavam alguma contra-indicação ao seu uso. Discutiu-se a necessidade de qualificar a aderência dos profissionais de saúde às recomendações de manejo do diabetes.A study was conducted in 1998 with the aim of assessing adequacy of clinical management of diabetic patients attending public health services in Pelotas, Brazil. Patients were interviewed to gather data on medical consultation, disease, and treatment. Data analysis focused on the "type of treatment" variable with three categories: diet, physical activity, and drug treatment. Seventy-six percent of the patients reported having received nutritional orientation. Only 50% of them reported having followed their diet during the preceding 15 days. Also, 75% of patients reported having received recommendations to perform physical activity. However, only one third had practiced some exercise in the previous month. Among 377 interviewed, 289 (77% were on medication, and among the patients taking oral hypoglycemic agents many had at least one contraindication. The article discusses the need to enhance physicians' adherence to

  3. Resting pulse rate among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Frequência do pulso de repouso em adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Pedro C. Hallal

    2010-10-01

    Full Text Available The aim of this study was to describe resting pulse rate and associated factors among adolescents. This was a cross-sectional analysis nested in a prospective cohort study, including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil in 1993, representing 87.5% of the original cohort. Pulse rate was measured with an electronic device at the beginning and end of the interview, and the mean value was used in the analyses. Mean pulse rate was 78.4bpm (SD = 11.0 in the total sample, 76.5bpm (SD = 10.7 in boys, and 80.2bpm (SD = 10.9; p O objetivo do estudo foi descrever a freqüência do pulso de repouso em adolescentes e avaliar variáveis associadas. Trata-se de análise transversal aninhada a um estudo de coorte prospectivo, incluindo 4.452 adolescentes nascidos em Pelotas, Rio Grande do Sul, Brasil, em 1993, os quais representam 87,5% da coorte original. A freqüência do pulso foi mensurada no início e ao final da entrevista com aparelho digital, sendo o valor médio utilizado nas análises. O valor médio da freqüência do pulso foi de 78,4bpm (DP = 11,0, sendo de 76,5bpm (DP = 10,7 nos meninos e 80,2bpm (DP = 10,9; p < 0,001 nas meninas. Os adolescentes com pele preta apresentaram valores mais baixos da freqüência do pulso. Houve uma forte associação positiva entre pressão arterial e freqüência do pulso. O escore de atividade física associou-se inversamente com a freqüência do pulso somente na análise bruta. Valores elevados de freqüência do pulso estão fortemente relacionados com valores elevados de pressão arterial, sendo ambas variáveis preditoras do risco de doenças crônicas na vida adulta.

  4. RS trigger based relaxation oscillator for temperature measurement circuit

    ZOU Zhi-ge; ZOU Xue-cheng; JIAN Wen-xiang; LEI Jian-ming

    2008-01-01

    Resistance-to-time converter is always used for digital temperature measurement. An reset-set (RS) trigger based, relaxation oscillator based temperature measurement circuit, which is used to convert the change of thermistor sensor into a frequency signal for later processing, has been presented in this article. The RS trigger, which is composed of two inverters designed with distinct logical transition threshold voltages by changing the metal-oxide-semiconductor (MOS) transistor gains, has the same function as the Schmitt trigger in the relaxation oscillator. The advantage of the RS trigger based Schmitt trigger is that it reduces the dependence to supply voltage, chip temperature, and process variation. This temperature measurement circuit has been applied in a clinical thermometer chip that can measure temperature to an accuracy of better than 0.05℃ down to 1.1 V battery voltage. It is fabricated in 0.5double metal single poly complementary MOS (CMOS) process.

  5. MOA-2010-BLG-523: 'FAILED PLANET' = RS CVn STAR

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A max ∼ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge.

  6. Testing for Parameter Instability using the R/S Statistic

    Michael Harrison; Glenn Treacy

    1998-01-01

    This paper explores the use of the R/S statistic as a means of checking for parameter instability. The nature and properties of the statistic are described, and its behaviour and power in the context of three situations of structural change are examined. The results suggest that the R/S statistic has an ability to detect shifts in means and changes in the intercept of a regression relationship. Moreover, it is more powerful than the OLS variant of the well known cumulative sum of squares resi...

  7. Validation of Omron RS8, RS6, and RS3 home blood pressure monitoring devices, in accordance with the European Society of Hypertension International Protocol revision 2010

    Takahashi H

    2013-05-01

    Full Text Available Hakuo Takahashi, Masamichi Yoshika, Toyohiko YokoiDepartment of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, JapanBackground: Allowing patients to measure their blood pressure at home is recognized as being of clinical value. However, it is not known how often these measurements are taken correctly. Blood pressure monitors for home use fall into two types based on the position of the cuff, ie, at the upper arm or the wrist. The latter is particularly convenient, as measurements can be taken fully clothed. This study aimed to evaluate the performance of the wrist-type blood pressure monitors Omron RS8 (HEM-6310F-E, Omron RS6 (HEM-6221-E, and Omron RS3 (HEM-6130-E.Methods: A team of three trained doctors validated the performance of these devices by comparing the measurements obtained from these devices with those taken using a standard mercury sphygmomanometer. All the devices met the validation requirements of the European Society of Hypertension International Protocol revision 2010.Results: The difference in blood pressure readings between the tested device and the standard mercury sphygmomanometer was within 3 mmHg, which is acceptable according to the European Society of Hypertension guidelines.Conclusion: All the home devices tested were found to be suitable for measuring blood pressure at home because their performance fulfilled the requirement of the guidelines.Keywords: blood pressure, device, European Society of Hypertension, guideline, measurement, validation

  8. Association Study of Polymorphisms rs4552569 and rs17095830 and the Risk of Ankylosing Spondylitis in a Taiwanese Population

    Wei, James Cheng-Chung; Hsu, Yu-Wen; Hung, Kuo-Sheng; Wong, Ruey-Hong; Huang, Chun-Huang; Liu, Yi-Tzu; Guo, Yuh-Cherng; Ikegawa, Shiro; Chang, Wei-Chiao

    2013-01-01

    Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. ...

  9. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss*

    Cao, Yun-lei; Zhang, Zhao-Feng; Wang, Jian; Miao, Mao-hua; Xu, Jian-hua; Shen, Yue-Ping; Chen, Ai-Min; Du, Jing; Yuan, Wei

    2016-01-01

    Recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs605...

  10. Extended Methodology of RS Design and Instances Based on GIP

    Qian-Hong Wu; Bo Qin; Yu-Min Wang

    2005-01-01

    Abe et al. proposed the methodology of ring signature (RS) design in 2002 and showed how to construct RS with a mixture of public keys based on factorization and/or discrete logarithms. Their methodology cannot be applied to knowledge signatures (KS) using the Fiat-Shamir heuristic and cut-and-choose techniques, for instance, the Goldreich KS.This paper presents a more general construction of RS from various public keys if there exists a secure signature using such a public key and an efficient algorithm to forge the relation to be checked if the challenges in such a signature are known in advance. The paper shows how to construct RS based on the graph isomorphism problem (GIP). Although it is unknown whether or not GIP is NP-Complete, there are no known arguments that it can be solved even in the quantum computation model. Hence, the scheme has a better security basis and it is plausibly secure against quantum adversaries.

  11. RS485 optical router for HIRFL-CSR

    A communication equipment-RS485 optical router has been developed to satisfy requirements of control system communication network of HIRFL-CSR (Heavy Ion Research Facility at Lanzhou-Cooling Storage Ring). The equipment is compatible with multiple communication protocols, such as Ethernet, RS232 and RS485 standard. It can be used to setup the RS485 communication network quickly and connected to the Ethernet easily. The fiber optical interface is introduced to facilitate the connection with the network of industrial Fiber Optics Communication (FOC), which expands the application field of the equipment in a large extent. This paper introduces the details of the equipment, including the design of the circuit and software, features of the equipment and how it works in the whole control system network. Its application in the HIRFL-CSR control system shows that the equipment is in accordance with the general requirement of automatic control communication system. It could also be used in other industrial automatic control fields. (authors)

  12. 7q21-rs6964587 and breast cancer risk

    Milne, Roger L; Lorenzo-Bermejo, Justo; Burwinkel, Barbara;

    2011-01-01

    Using the Breast Cancer Association Consortium, the authors previously reported that the single nucleotide polymorphism 7q21-rs6964587 (AKAP9-M463I) is associated with breast cancer risk. The authors have now assessed this association more comprehensively using 16 independent case-control studies....

  13. Restoring New Agegraphic Dark Energy in RS II Braneworld

    Jamil, Mubasher; Karami, Kayoomars; Sheykhi, Ahmad

    2010-01-01

    Motivated by recent works [1,2], we investigate new agegraphic model of dark energy in the framework of RS II braneworld. We also include the case of variable gravitational constant in our model. Furthermore, we establish correspondence between the new agegraphic dark energy with other dark energy candidates based on scalar fields.

  14. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    Fernandez, Luca; Jenssen, Håvard; Bains, Manjeet;

    2012-01-01

    through ParRS. Here, we report the identification of a new two-component system, CprRS, which, upon exposure to a wide range of antimicrobial peptides, triggered the expression of the LPS modification operon. Thus, mutations in the cprRS operon blocked the induction of the arn operon in response to...... several antimicrobial peptides independently of ParRS but did not affect the response to low Mg2+. Distinct patterns of arn induction were identified. Thus, the responses to polymyxins were abrogated by either parR or cprR mutations, while responses to other peptides, including indolicidin, showed...... differential dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies...

  15. Radiation Dry Bias of the Vaisala RS92 Humidity Sensor

    Vomel, H.; Selkirk, H.; Miloshevich, L.; Valverde-Canossa, J.; Valdes, J.; Kyro, E.; Kivi, R.; Stolz, W.; Peng, G.; Diaz, J. A.

    2007-01-01

    The comparison of simultaneous humidity measurements by the Vaisala RS92 radiosonde and by the Cryogenic Frostpoint Hygrometer (CFH) launched at Alajuela, Cosla Rica, during July 2005 reveals a large solar radiation dry bias of the Vaisala RS92 humidity sensor and a minor temperature-dependent calibration error. For soundings launched at solar zenith angles between 10" and 30 , the average dry bias is on the order of 9% at the surface and increases to 50% at 15 km. A simple pressure- and temperature-dependent correction based on the comparison with the CFH can reduce this error to less than 7% at all altitudes up to 15.2 km, which is 700 m below the tropical tropopause. The correction does not depend on relative humidity, but is able to reproduce the relative humidity distribution observed by the CFH.

  16. THE HISTORY OF LABORATORY ANIMALS AND THE 3RS

    Alstrup, Aage Kristian Olsen

    This talk will give an introduction to the history of the use of laboratory animals with focus on the history of the three Rs (3Rs). We will see how animal experimentation has been performed early in our civilization, and how the suffering of animals has been justified. This will include Rene...... of animals in research, which led to Denmark passing one of Europe's first laws to protect laboratory animals. A law that was later modified after the author Karen Blixen took part in the debate. In the middle of 1950s the Universities Federation for Animal Welfare decided to sponsor research in the...... field of laboratory animal welfare. Two years later two English scientists, zoologist William W.S. Russell and micro-biologist, Rex L. Burch prepared a report on the ethical aspects of using laboratory animals. In 1959 (hundred years after Charles Darwin’s “The Origin of Species”) they published the...

  17. R.S. Peters' Comprehensive Theory of Moral Education

    Cuypers, Stefaan

    2014-01-01

    This article presents R.S. Peters’ theory of moral education embedded in his broad conception of morality. The author examines Peters’ views against the background of Kohlberg’s stage theory of moral development; hence, the positions of both thinkers are interwoven throughout the discussion. It addresses some central issues relevant to moral education such as, for example: cognitive and affective aspects of morality, and the acquisition of virtues. In the article the author argues that Peters...

  18. HDL IMPLEMENTATION OF ALGEBRAIC SOFT DECISION ALGORITHM FOR RS CODES

    M. Revathy; Saravanan, R.

    2013-01-01

    Reed Solomon (RS) codes are widely used to detect and correct data errors in transmission andstorage systems. Hence it is used in many digital communication and storage devices. In existing systemReformulated inversion less Burst error correcting (RiBC) algorithm is used. But it lacks in speed,throughput & area. To overcome this Algebraic Soft Decision (ASD) algorithm is proposed. This Proposedalgorithm is based on Unified VLSI architecture for correcting burst errors as well as random errors...

  19. Spectrophotometry of RS Oph during the nebular phase

    Bohigas, J.; Echevarria, J. (Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Inst. de Astronomia); Diego, F. (University Coll., London (UK). Dept. of Physics and Astronomy); Sarmiento, J.A. (Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Facultad de Ciencias)

    1989-06-15

    Blue-wavelength spectroscopic observations of RS Oph, 201 day after the 1985 outburst are presented. An analysis of the TiO bands indicates a spectral type M4III for the secondary and a distance of 2 kpc to the system. The system of forbidden lines is excited by a shock wave, whereas Balmer emission is mainly produced by photoionization. The source of photons is probably residual thermonuclear burning occurring at the surface of the white dwarf. (author).

  20. Spectrophotometry of RS Oph during the nebular phase

    Blue-wavelength spectroscopic observations of RS Oph, 201 day after the 1985 outburst are presented. An analysis of the TiO bands indicates a spectral type M4III for the secondary and a distance of 2 kpc to the system. The system of forbidden lines is excited by a shock wave, whereas Balmer emission is mainly produced by photoionization. The source of photons is probably residual thermonuclear burning occurring at the surface of the white dwarf. (author)

  1. MOA-2010-BLG-523 : "Failed Planet" = RS CVn Star

    Gould, A.; Yee, J. C.; Bond, I. A.; Udalski, A; Han, C; J\\xf8rgensen, U. G; Greenhill, J.; Tsapras, Y.; Pinsonneault, M. H.; Bensby, T.; Allen, W.; Almeida, L. A.; Bos, M.; Christie, G. W.; DePoy, D. L.

    2013-01-01

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlen...

  2. Approximating the distribution of the R/s statistic

    Denis Conniffe; Spencer, John E.

    2000-01-01

    The R/s statistic, used for many years in hydrology, is increasingly employed in economics, although deficiencies in knowledge about its exact distribution have inhibited progress. Harrison and Treacy (1997) have described some applications and addressed distributional problems through Monte Carlo simulation, deriving close to exact significance test points for a range of sample values. But there remain advantages to algebraic approximations to the exact distribution in relaxing restrictions ...

  3. Solvation quantities from a COSMO-RS equation of state

    Highlights: • Extension of the successful COSMO-RS model to an equation-of-state model. • Two scaling constants, obtained from atom-specific contributions. • Overall estimation of the solvation quantities and contributions. - Abstract: This work focuses on the extension of the successful COSMO-RS model of mixtures into an equation-of-state model of fluids and its application for the estimation of solvation/hydration quantities of a variety of chemical substances. These quantities include free-energies, enthalpies and entropies of hydration as well as the separate contributions to each of them. Emphasis is given on the estimation of contributions from the conformational changes of solutes upon solvation and the associated restructuring of solvent in its immediate neighborhood. COSMO-RS is a quantum-mechanics based group/segment contribution model in which the Quasi-Chemical (QC) approach is used for the description of the non-random distribution of interacting segments in the system. Thus, the equation-of-state development is done through such a QC framework. The new model will not need any adjustable parameters for the strong specific interactions, such as hydrogen bonds, since they will be provided by the quantum-mechanics based cosmo-files – a key feature of COSMO-RS model. It will need, however, one volumetric and one energy parameter per fluid, which are scaling constants or molecular descriptors of the fluid and are obtained from rather easily available data such as densities, boiling points, vapor pressures, heats of vaporization or second virial coefficients. The performance and the potential of the new equation-of-state model to become a fully predictive model are critically discussed

  4. Utilização de adoçantes dietéticos entre adultos em Pelotas, Rio Grande do Sul, Brasil: um estudo de base populacional Use of diet sweeteners by adults in Pelotas, Rio Grande do Sul State, Brazil: a population-based study

    Roberta de Vargas Zanini

    2011-05-01

    Full Text Available Estudo de base populacional avaliou o uso de adoçantes dietéticos na população com idade ≥ 20 anos, residente na zona urbana do Município de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu entre janeiro e julho de 2010, e 2.732 indivíduos foram entrevistados. Além das questões específicas quanto ao uso de adoçante dietético, foram coletadas informações sobre características demográficas, socioeconômicas e de saúde. Para as análises estatísticas, foram utilizados testes qui-quadrado de heterogeneidade e de tendência linear. A prevalência de uso de adoçante dietético foi 19% (IC95%: 17,1; 20,9, sendo 3,7 vezes maior entre idosos do que entre aqueles com 20-29 anos de idade. Nível econômico e estado nutricional apresentaram associação direta e significativa com o desfecho. Quase 98% da amostra utilizou adoçantes na forma líquida, sendo os mais consumidos (89,2% aqueles constituídos por sacarina e ciclamato de sódio. A mediana de ingestão diária foi 10 gotas (P25; P75 = 6; 18, entre usuários de adoçante líquido, ou 1,5 sachet (P25; P75 = 1; 4, para adoçante em pó. O uso de adoçante dietético foi maior entre mulheres e idosos.This population-based study evaluated the use of diet sweeteners by adults (> 20 years in Pelotas, Rio Grande do Sul State, Brazil. Data were collected from January to July 2010 (n = 2,732. Besides specific questions on diet sweeteners, demographic, socioeconomic, and health characteristics were recorded. Heterogeneity and linear trend chi-square tests were used for the statistical analysis. Prevalence of sweetener use was 19% (95%CI: 1.1-20.9, and was 3.7 times higher in elderly individuals as compared to 20-29-year-olds. Economic level and nutritional status were significantly associated with sweetener use. Nearly 98% of the sample used liquid sweeteners; the most frequently consumed (89.2% were those containing saccharin or sodium cyclamate. Average intake was 10 drops

  5. Tendências e diferenciais na saúde materno-infantil: delineamento e metodologia das coortes de 1982 e 1993 de mães e crianças de Pelotas, Rio Grande do Sul Trends and defferentials in maternal and child health: design and metodology of the 1982 and 1993 birth cohort studies in Pelotas, Rio Grande do Sul

    Cesar G. Victora

    1996-01-01

    Full Text Available Mudanças ocorridas na última década em termos econômicos e assistenciais podem haver afetado a saúde materno-infantil. Dois estudos foram realizados em Pelotas, Rio Grande do Sul. As coortes de mães e recém-nascidos nos anos de 1982 e 1993 foram estudadas desde o nascimento. As mães foram identificadas nos hospitais-maternidade e responderam a um questionário padronizado, sendo seus filhos examinados. Mais de 99% dos recém-nascidos foram incluídos nas coortes, totalizando 5.914 nascidos vivos em 1982 e 5.249 em 1993. A mortalidade das crianças foi monitorizada, e em 1993 as hospitalizações também o foram. Em 1982, tentou-se localizar cerca de 25% das crianças aos 12 meses de idade e todas com a idade média de vinte meses. Foi possível encontrar cerca de 82% das crianças aos 12 meses e, graças a uma mudança de estratégia, 87% aos vinte meses. Em 1993, tentou-se acompanhar 20% das crianças e mais todos os recém-nascidos de baixo peso aos 12 meses de idade, sendo 95% localizados. Este artigo descreve os principais aspectos metodológicos de ambos os estudos, cujos principais resultados estão incluídos nos próximos artigos desse suplemento.Important changes have taken place in both the economy and health care in Brazil since 1980 and may have affected maternal and child health. Two studies in the city of Pelotas in Southern Brazil provide a unique opportunity for assessing these issues. Cohorts of mothers and infants from 1982 and 1993 were studied from the time of delivery. In both years, all mothers identified in the city's maternity hospitals answered a standardized questionnaire, and their infants were examined. Over 99% of all children born in the city in each of the two years were included in the cohorts, totalling 5,914 live births in 1982 and 5,249 in 1993. Deaths among these children were monitored prospectively, as were all hospital admissions in the 1993 cohort. In 1982, attempts were made to locate a 25% sample

  6. Maternal-child health in Pelotas, Rio Grande do Sul State, Brazil: major conclusions from comparisons of the 1982, 1993, and 2004 birth cohorts Saúde materno-infantil em Pelotas, Rio Grande do Sul, Brasil: principais conclusões das comparações de coortes de nascimento de 1982, 1993 e 2004

    Fernando C. Barros

    2008-01-01

    Full Text Available Important changes were observed in maternal characteristics, health care indicators, and child health during the 22 years covered by the three population-based birth cohort studies conducted in the city of Pelotas, Southern Brazil. Maternal education levels improved, cigarette smoking during pregnancy was reduced, and birth intervals became longer. Also, there were more single mothers, and maternal obesity increased. Coverage of antenatal and delivery care by professionals improved, but inductions and caesarean sections increased markedly, the latter accounting for 45% of deliveries in 2004. With regard to child health, the reductions in neonatal and infant mortality rates were modest, and the significant increase in preterm births - 14.7% of all births in 2004 - appears to have colluded with this stagnation. Other infant health indicators, such as immunization coverage and breastfeeding duration, showed improvements over the period. Regarding infant nutrition, malnourishment at age 12 months decreased, but the prevalence of overweight was higher in 2004. The existence of three population-based birth cohorts using comparable methodology allowed for the study of important secular trends in maternal and child health.Foram observadas mudanças importantes nas características maternas, de assistência à saúde e de saúde infantil ao longo dos 22 anos cobertos pelas três coortes de base populacional na cidade de Pelotas, Rio Grande do Sul. Melhorou o nível de escolaridade materna, houve uma redução no tabagismo durante a gravidez e aumentou o espaçamento entre filhos. Além disso, havia mais mães solteiras e aumentou a obesidade materna. Melhoraram a cobertura pré-natal e assistência ao parto por profissionais, mas houve um aumento marcante nos partos induzidos e nas cesarianas, que representaram 45% do total de partos em 2004. Com relação à saúde infantil, houve uma redução apenas modesta nas taxas de mortalidade neonatal e infantil

  7. Alkaline protease from Thermoactinomyces sp. RS1 mitigates industrial pollution.

    Verma, Amit; Ansari, Mohammad W; Anwar, Mohmmad S; Agrawal, Ruchi; Agrawal, Sanjeev

    2014-05-01

    Proteases have found a wide application in the several industrial processes, such as laundry detergents, protein recovery or solubilization, prion degradation, meat tenderizations, and in bating of hides and skins in leather industries. But the main hurdle in industrial application of proteases is their economical production on a large scale. The present investigation aimed to exploit the locally available inexpensive agricultural and household wastes for alkaline protease production using Thermoactinomyces sp. RS1 via solid-state fermentation (SSF) technique. The alkaline enzyme is potentially useful as an additive in commercial detergents to mitigate pollution load due to extensive use of caustic soda-based detergents. Thermoactinomyces sp. RS1 showed good protease production under SSF conditions of 55 °C, pH 9, and 50 % moisture content with potato peels as solid substrate. The presented findings revealed that crude alkaline protease produced by Thermoactinomyces sp. RS1 via SSF is of potential application in silver recovery from used X-ray films. PMID:24122212

  8. X-ray spectroscopy of RS CVn stars with EXOSAT

    We present the results of spectral analysis of a sample of RS CVn stars observed with the EXOSAT Observatory. Data from both the Medium Energy and Low Energy experiments are analysed assuming simple spectral models (one-temperature, two-temperature, continuous emission measure distribution models). We investigate the dependence of the fitted coronal parameters on the signal-to-noise ratio and the instrument response function, and compare the results with those previously obtained by the Einstein IPC and SSS experiments. We find evidence for multi-temperature coronal structures in RS CVn stars as well as indications of intrinsic differences in the temperature stratification of different stars. The simple power law EM ∼ Tα assumed by us for the continuous emission measure distribution appears to be inconsistent with several of our observations. For the others, we derive power law indices α that are higher than those found for solar coronal loops and interpret this as evidence that the coronae of RS CVn binaries involve structures different from those typically observed on the Sun

  9. AB200. Association of rs3129878 and rs498422in the HLA region with non-obstructive azoospermia in the Han Chinese population

    Zou, Shasha; Song, Pingping; Chen, Tingting; Jianhua CHEN; He, Xiaojin; Xu, Peng(Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 100190, Beijing, China); Liang, Ming; Luo, Kailing; Zhu, Xiaobin; Tian, Erpo; Du, Qiang; Wen, Zujia; Li, Zhiqiang; Wang, Meng; Sha, Yanwei

    2014-01-01

    Objective The previous genome-wide association study (GWAS) of non-obstructive azoospermia (NOA) in the Han Chinese populations identified two NOA-risk loci (rs498422 and rs3129878) within the HLA region, and provided strong evidence for the genetic influence of male infertility. A further case-control study found that only rs3129878 remained to be significantly associated with NOA in the Japanese population. Therefore, we conducted the association study to further validate whether the risk o...

  10. TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population

    Song, Yanmin; Liu, Huarong; Long, Lili; Zhang, Ning; Liu, Yunhai

    2015-01-01

    Abstract The objective of this study was to explore the association of toll-like receptor (TLR) 4 rs1927911 and TLR2 rs5743708 with atherosclerotic cerebral infarction (ACI) and their effects on blood pressure, fasting blood glucose, and blood lipids in the Han population of Hunan Province. TLR4 rs1927911 and TLR2 rs5743708 were detected by polymerase chain reaction and restriction fragment length polymorphism in 170 patients with ACI and 149 healthy controls. Our results indicated that the g...

  11. Physico-chemical, functional and structural properties of RS3/RS4 from kidney bean (Phaseolus vulgaris) cultivars.

    Gani, Adil; Jan, Amreen; Shah, Asima; Masoodi, F A; Ahmad, Mudasir; Ashwar, Bilal Ahmad; Akhter, Rehana; Wani, Idrees Ahmed

    2016-06-01

    Starch isolated from four kidney bean cultivars (Yellow bean, Red bean, Black bean and White bean) were physically and chemically modified in order to prepare resistant starch (RS3/RS4). Following the Heat-moisture treatment (HMT) and Citric acid modification (CT) of the native starch, the amylose content got decreased whereas bulk and tapped density (g/ml) increased. Both HMT and CT reduced the swelling power and the solubility of native starch. Pasting temperature increased and peak, breakdown, final, and set-back viscosity decreased after both the modifications. Fourier Transform Infrared Spectroscopy (FTIR) analysis displayed peaks at 1020cm(-1) in HMT and 1724cm(-1) in CT starches. Differential Scanning Calorimetry (DSC) analysis revealed that samples were more stable after modification. X-ray diffraction (XRD) analysis revealed reordering of chain segments to more crystalline structure. These results suggested modifications resulted in starch with improved properties and could be a possible method for the RS preparation with better thermal stability. PMID:26976068

  12. Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

    Noriyuki eFuku

    2015-05-01

    Full Text Available There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR gene, rs1800795 in the interleukin-6 (IL6 gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1 gene. To gain insight into their functionality (which is yet unknown, here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n=138, age range 100-111 years (114 women] and healthy controls [n=334, 20-50 years (141 women] of the same ethnic and geographic origin (Spain. We also studied healthy centenarians [n=79, 100-104 years (40 women] and controls [n=316, 27-81 years (156 women] from Italy, and centenarians [n=742, 100-116 years (623 women] and healthy controls [n=499, 23-59 years (356 women] from Japan. The THRH rs7832552 T-allele and ACSL1 rs6552828 A-allele up-regulated luciferase activity compared to the C and G-allele, respectively (P≤0.001. Yet we found no significant association of EL with rs7832552, rs1800795 or rs6552828 in any of the 3 cohorts. Further research is needed with larger cohorts of centenarians of different origin as well as with younger old people.

  13. COMPARISON OF TUNNELLING METHODS NATM AND ADECO-RS

    Linda Černá Vydrová

    2015-04-01

    Full Text Available The New Austrian Tunnelling Method (NATM has been often used in the Czech Republic in last two decades. One of the methods, without application in the Czech Republic, is an Italian method called ADECO-RS, which has reached significant use in Italy and some other countries. It is the method of controlled deformation, which uses mainly the horizontal anchoring of the tunnel face to reinforce the area in front of the face (advance core. This technology is especially important in weak and soft rocks where is necessary to excavate quickly and smoothly with minimum disruption of initial stress state of the rock mass in the vicinity of the excavation. The use of NATM can be in some cases uneconomical and technically inadequately challenging and in such cases would be appropriate to choose another technology. Given the facts above, in the Czech environment there is no data available for comparison of these methods not only in terms of numerical modelling, but also in terms of feasibility and usability. The paper summarizes history of the tunnelling methods and it is closer devoted to NATM and ADECO-RS tunnelling approaches. The basic principles of both methods are set and further the comparison of these methods is made on a theoretical level. The paper hereinafter includes the analysis of fibreglass face anchors application during the construction of three-aisled Veleslavín Station and the impact assessment of tunnel face anchoring during the excavation of ventilation tunnel on the newly built part of the Prague Metro „V.A“. The paper also deals with practical knowledge gained during the technical visit of Italian Val di Sambro Tunnel which is built according to ADECO-RS approach. These findings are essential for the correct interpretation of Lunardi method.

  14. Hakusanamainonnan kehittäminen : Case- RS Finland

    Vepsä, Tia

    2015-01-01

    Tämä opinnäytetyö on tehty yhteistyössä YEInternationalin kanssa, yrityksen RS- tuotemyynnin ja markkinoinnin osaston toimeksiantona. Tämä tutkimusprojekti on toteutettu hakukonemainonnan kehittämiseksi. Hakukone Googlella on olemassa mainostuspalvelu, jonka avulla yritys voi tuoda itsensä hakutuloksissa esille määritellyin mainoksin ja hakusanoin. AdWordsilla mainostamista pyritään kehittämään tehokkaammaksi Googlen tarjoamien aiempaa toimintaa raportoivien tilastotietojen avulla. Yrityksen ...

  15. PC interfacing using Centronics, RS232 and game ports

    An, Pei

    1998-01-01

    The main links with your PC and the outside world are the centronic port, used for connecting the printer, the RS232 port, used for the mouse, and the games port for a joystick. This book explores how these input/output (I/O) ports can be put to use through a range of other interfacing applications. This is especially useful for laptop and palmtop PCs which cannot be fitted with internal I/O cards. A novel approach is taken by this book, combining the hardware through which the ports can be explored, and the software programming needed to carry out a range of experiments.Circuits are p

  16. RASSF1A and the rs2073498 Cancer Associated SNP

    Donninger, Howard; Barnoud, Thibaut; Nelson, Nick; Kassler, Suzanna; CLARK, Jennifer; Cummins, Timothy D.; Powell, David W.; Nyante, Sarah; Millikan, Robert C.; Clark, Geoffrey J.

    2011-01-01

    RASSF1A is one of the most frequently inactivated tumor suppressors yet identified in human cancer. It is pro-apoptotic and appears to function as a scaffolding protein that interacts with a variety of other tumor suppressors to modulate their function. It can also complex with the Ras oncoprotein and may serve to integrate pro-growth and pro-death signaling pathways. A SNP has been identified that is present in approximately 29% of European populations [rs2073498, A(133)S]. Several studies h...

  17. Early determinants of attention and hyperactivity problems in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Determinantes precoces de problemas de atenção e hiperatividade na adolescência: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Luciana Anselmi

    2010-10-01

    Full Text Available The aim of this study was to assess early determinants of attention and hyperactivity problems in adolescents. In 1993, all hospital births in the city of Pelotas, Rio Grande do Sul State, Brazil, were monitored and mothers were interviewed (N = 5,249. At 11 years of age, 4,423 mothers answered the Strengths and Difficulties Questionnaire (SDQ in order to evaluate attention and hyperactivity problems in the adolescents. Crude and adjusted prevalence ratios were calculated using Poisson regression. Prevalence of attention and hyperactivity problems was 19.9%. Factors associated with the outcome in the adjusted analysis were: male gender, low family income, smoking during pregnancy, minor psychiatric disorders in the mother, and history of child's behavioral/emotional problems at four years of age. Early life events impacted attention and hyperactivity problems in adolescence. Risk factors for attention and hyperactivity problems found in this study were similar to those reported in other cultures.O objetivo deste trabalho foi estudar determinantes precoces dos problemas de atenção e hiperatividade em adolescentes. Em 1993, os nascimentos foram recrutados e as mães entrevistadas (n = 5.249. Aos 11 anos, 4.423 mães responderam ao Strengths and Difficulties Questionnaire (SDQ para avaliar problemas de atenção e hiperatividade nos adolescentes. Variáveis socioeconômicas, demográficas, biológicas e psicológicas foram investigadas como prováveis fatores de risco. Razões de prevalência brutas e ajustadas foram calculadas com regressão de Poisson. A prevalência de problemas de atenção e hiperatividade foi 19,9%. Sexo masculino, baixa renda familiar, tabagismo materno na gestação, transtornos psiquiátricos maternos e problemas de comportamento/emocionais do adolescente aos quatro anos permaneceram associados na análise ajustada. Eventos do início da vida influenciaram os problemas de atenção e hiperatividade na adolescência. Os

  18. Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

    Linhong Yuan

    2015-09-01

    Full Text Available Apolipoprotein E (APOE and oxidative damage were correlated with the risk of Alzheimer’s disease (AD. Glutathione S-transferase (GST polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in old Chinese adults, a community-based cross-sectional study was carried out in 477 Chinese adults aged from 55 to 75. Information on demography and lifestyle of the participants was collected with a questionnaire. Cognitive function was measured by using a Montreal Cognitive Assessment (MoCA test. Fasting venous blood samples were collected for APOE rs429358, rs7412 and GSTM1/T1 genotyping, and parameter measurement. No association of APOE rs7412, rs429358 and GSTM1/T1 polymorphisms with cognition was detected in the old Chinese adults. APOE rs429358, rs7412 polymorphism was mainly associated with plasma α-tocopherol, low density lipoprotein cholesterol (LDL-C and plasma total antioxidant capacity (T-AOC levels (p < 0.05. Interaction of APOE rs429358 and GSTT1 genotype on the plasma triglyceride (TG level and erythrocyte catalase (CAT and GST enzyme activities were detected (p < 0.05. The subjects with APOE rs429358 T/C + C/C and GSTT1− genotype were found to have the highest plasma TG level, erythrocyte CAT enzyme activity, and the lowest GST enzyme activity compared to subjects with other genotypes (p < 0.05. Lowest erythrocyte CAT enzyme activity and highest glutathione peroxidase (GSH-Px enzyme activity were detected in the subjects with APOE rs7412 T/C + T/T and GSTM1+ genotype as compared with subjects with other genotypes. The levels of plasma and erythrocyte antioxidant parameters were APOE genotype associated. GSTM1 or GSTT1 genotype modified the influence of APOE rs7412, rs429358 polymorphism on antioxidant parameters.

  19. Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults.

    Yuan, Linhong; Liu, Jinmeng; Dong, Li; Cai, Can; Wang, Sisi; Wang, Bo; Xiao, Rong

    2015-01-01

    Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer's disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in old Chinese adults, a community-based cross-sectional study was carried out in 477 Chinese adults aged from 55 to 75. Information on demography and lifestyle of the participants was collected with a questionnaire. Cognitive function was measured by using a Montreal Cognitive Assessment (MoCA) test. Fasting venous blood samples were collected for APOE rs429358, rs7412 and GSTM1/T1 genotyping, and parameter measurement. No association of APOE rs7412, rs429358 and GSTM1/T1 polymorphisms with cognition was detected in the old Chinese adults. APOE rs429358, rs7412 polymorphism was mainly associated with plasma α-tocopherol, low density lipoprotein cholesterol (LDL-C) and plasma total antioxidant capacity (T-AOC) levels (p < 0.05). Interaction of APOE rs429358 and GSTT1 genotype on the plasma triglyceride (TG) level and erythrocyte catalase (CAT) and GST enzyme activities were detected (p < 0.05). The subjects with APOE rs429358 T/C + C/C and GSTT1- genotype were found to have the highest plasma TG level, erythrocyte CAT enzyme activity, and the lowest GST enzyme activity compared to subjects with other genotypes (p < 0.05). Lowest erythrocyte CAT enzyme activity and highest glutathione peroxidase (GSH-Px) enzyme activity were detected in the subjects with APOE rs7412 T/C + T/T and GSTM1+ genotype as compared with subjects with other genotypes. The levels of plasma and erythrocyte antioxidant parameters were APOE genotype associated. GSTM1 or GSTT1 genotype modified the influence of APOE rs7412, rs429358 polymorphism on antioxidant parameters. PMID:26404360

  20. Moscas frugívoras e seus parasitoides nos municípios de Pelotas e Capão do Leão, Rio Grande do Sul, Brasil Frugivorous flies and their parasitoids in the cities of Pelotas and Capão do Leão, Rio Grande do Sul, Brazil

    Adrise Medeiros Nunes

    2012-01-01

    Full Text Available As moscas frugívoras (Tephritoidea são as principais pragas da fruticultura de clima temperado no Brasil. O objetivo do presente trabalho foi avaliar a infestação desses dípteros e a ocorrência de seus parasitoides em frutíferas nos municípios de Pelotas e Capão do Leão, localizados na região Sul, nas safras agrícolas de 2007/08 e 2008/09. Foram coletados frutos de araçazeiro-amarelo e vermelho (Psidium cattleianum Sabine, 1821, butiazeiro [Butia capitata (Mart. Becc., 1916], caquizeiro (Diospyros kaki Linnaeus, 1753, cerejeira-do-mato (Eugenia involucrata DC., 1828, goiabeira [Psidium guajava (Linnaeus, 1753], goiabeira-serrana [Acca sellowiana (Berg. Burret, 1941], nespereira [Eriobotrya japonica (Thunb. Lindley, 1822], pessegueiro [Prunus persicae (L. Batsch, 1801], pitangueira (Eugenia uniflora Linnaeus,1753 e uvalheira (Eugenia pyriformis Cambessèdes, 1832. Os frutos foram coletados e transportados para o laboratório, onde foram individualizados e determinados os seguintes parâmetros: índice de infestação das moscas, índice de parasitismo e frequência de indivíduos por espécie de parasitoide. Foram constatadas duas espécies de Tephritidae, Anastrepha fraterculus (Wiedemann, 1830 (90,5% e Ceratitis capitata (Wiedemann, 1824 (9,5% e duas de Lonchaeidae, Neosilba zadolicha McAlpine & Steyskal, 1982 (87,8% e uma espécie ainda não descrita, referida como Neosilba n. sp. 3 (12,2%. Anastrepha fraterculus é a espécie mais abundante nos dois municípios, sendo constatada na maioria das frutíferas coletadas. Caquizeiro e goiabeira foram os hospedeiros que apresentaram o maior índice de infestação por C. capitata. Quanto às espécies de Neosilba, a maior infestação ocorreu em frutos de goiabeira-serrana. Dos parasitoides emergidos, foram identificadas três espécies, sendo duas de Braconidae, Doryctobracon areolatus (Szépligeti, 1911 (52,6% e Opius bellus (Gahan, 1930 (27,5% e uma espécie de Figitidae, Aganaspis

  1. Rs measurement of HTS films in millimeter wave region using dielectric resonator method

    The parallel plate dielectric resonator was applied to surface resistance (Rs) measurement of high temperature superconducting films with small area for the purpose of material research in early stage. Using 38 GHz resonance of TE013 mode, available measurement area in the film was diameter of 9 mm. From the theoretical calculation, the measurement at higher frequency had an advantage of less error in Rs that is caused by dielectric loss tangent (tanδ). The effect of dielectric loss is negligible at 38 GHz even using a sapphire with order of 10-7 of tanδ. In lower Rs region, Rs values of YBa2Cu3Oy that were measured at 38 GHz agreed well with that of standard measurement method at 22 GHz. However the difference of Rs between two methods became larger with increase of Rs. It is owing to poor signal to noise ratio at higher frequency

  2. NETWORK INTRUSION DETECTION METHOD BASED ON RS-MSVM

    Xiao Yun; Han Chongzhao; Zheng Qinghua; Zhang Junjie

    2006-01-01

    A new method called RS-MSVM (Rough Set and Multi-class Support Vector Machine) is proposed for network intrusion detection. This method is based on rough set followed by MSVM for attribute reduction and classification respectively. The number of attributes of the network data used in this paper is reduced from 41 to 30 using rough set theory. The kernel function of HVDM-RBF (Heterogeneous Value Difference Metric Radial Basis Function), based on the heterogeneous value difference metric of heterogeneous datasets, is constructed for the heterogeneous network data. HVDM-RBF and one-against-one method are applied to build MSVM. DARPA (Defense Advanced Research Projects Agency) intrusion detection evaluating data were used in the experiment. The testing results show that our method outperforms other methods mentioned in this paper on six aspects: detection accuracy, number of support vectors, false positive rate, false negative rate, training time and testing time.

  3. Depth Control for AUV Based on RS-LSSVM

    宋晓茹; 宋保维; 雷志勇; 梁庆卫

    2012-01-01

    Aimed at uncertainties and model' s impreciseness, nonlinearity and time-variability of depth control system in autonomous underwater vehicle ( AUV), a depth predictive control method was put forward based on rough set (RS) and least squares support vector machine (LSSVM). By using RS theory, the monitor data attribute of AUV was reduced to eliminate the redundant information and to improve efficiency. Then, LSSVM model was trained by using the reduced rules, and its parameters were optimized by using chaos theory for the higher accurate control. Taken an AUV typed NPS Phoenix as an example, its depth step response, horizontal rudder and pitch change were simulated. The simulation results show that the method improves the model' s accuracy and has better real-time response, fault-tolerant ability, reliability and strong anti-interfere capability.

  4. Photospheric imaging of the RS CVn system HR 1099

    Donati, J.-F.; Brown, S. F.; Semel, M.; Rees, D. E.; Dempsey, R. C.; Matthews, J. M.; Henry, G. W.; Hall, D. S.

    1992-01-01

    Spectropolarimetric, spectroscopic, and photometric observations of the RS CVn binary system HR 1099 = V711 Tau (K1IV+G5V) were made from Oct. 1988 to Jan. 1991. From Doppler imaging of the unpolarized spectra and the corresponding data, two maximum entropy images of the temperature distribution of the active K1 subgiant at epochs 1988.9 and 1990.9 were derived. Zeeman-Doppler imaging of the circularly polarized spectra has led to the first magnetic maps of a star other than the sun. The fragmentary observations made at epoch 1989.6 suggest that the star's magnetic field lines were emerging radially and/or poloidally from an equatorial warm region at that time, quite likely one of these reconstructed in the 1988.9 temperature image.

  5. HypoxamiRs: regulators of cardiac hypoxia and energy metabolism.

    Azzouzi, Hamid El; Leptidis, Stefanos; Doevendans, Pieter A; De Windt, Leon J

    2015-09-01

    Hypoxia and its intricate regulation are at the epicenter of cardiovascular research. Mediated by hypoxia-inducible factors as well as by several microRNAs, recently termed 'hypoxamiRs', hypoxia affects several cardiac pathophysiological processes. Hypoxia is the driving force behind the regulation of the characteristic metabolic switch from predominant fatty acid oxidation in the healthy heart to glucose utilization in the failing myocardium, but also instigates reactivation of the fetal gene program, induces the cardiac hypertrophy response, alters extracellular matrix composition, influences mitochondrial biogenesis, and impacts upon myocardial contractility. HypoxamiR regulation adds a new level of complexity to this multitude of hypoxia-mediated effects, rendering the understanding of the hypoxic response a fundamental piece in solving the cardiovascular disease puzzle. PMID:26197955

  6. ADAPTATION OF RESILIENCE SCALE (RS) TO THE TURK CULTURE: IT’S RELIABILITY AND VALIDITY

    TERZİ, Şerife

    2006-01-01

    This study investigates the reliability and validity of the Turkish adaptation of “Resilience Scale”. The sample consisted of 155 undergraduates from the Faculty of Education, Gazi University, Ankara. Scale used in the research was a 24-item Likert-type revised “Resilience Scale” (RS) with 7-point response format. The construct validity of RS was examined by factor analysis. To test concurrent validity, correlations between scores on RS and “Generalized Self-Efficacy Scale” were calculated. T...

  7. Creative Implementation of 3Rs Principles within Industry Programs: Beyond Regulations and Guidelines

    Bratcher, Natalie A; Reinhard, Gregory R

    2015-01-01

    The industry involved with using animals as an essential part of research has supported the theory and philosophy of the 3Rs for years. However, both the culture and approach surrounding the 3Rs is evolving rapidly, and many institutions are attempting to surpass the regulations and guidelines to implement the 3Rs for improved science and animal welfare. Regulatory documents and guidelines such as the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Public Health ...

  8. Processing of PLA/RS and PLA/Kenaf pellets into composite panels

    Dimeski, Dimko

    2006-01-01

    In this material the research is focused on preparation and characterization of PLA/RS and PLA/Kenaf cost – effective polymer composites as constructive materials for houses and offices. The technological procedure for production of PLA/RS and PLA /kenaf fiber composites was determined. Kenaf / PLA and PLA/RS preforms were molded by thermo compression in a closed mold. Various kinds of preforms with different thickness, specific weight and fiber / matrix ratios were molded. Th...

  9. Construction of REDD monitoring system using GIS and RS techniques

    Jungsoo Lee

    2012-06-01

    Full Text Available This study aimed to construct a MRV system for the REDD regions. The system was based on the GIS and Remote Sensing techniques, and it developed a method which could detect the land cover change area as well as evaluate its accuracy. GIS, the Remote Sensing technique and the statistical modelling technique were merged, and then we monitored areas of deforestation among the REDD regions. This study compared deforestation from administrative information (GIS deforestation1 with deforestation (RS deforestation extracted from satellite imagery by vegetation indices (NDVI, NBR, NDWI. The highest extraction accuracy that applies filtering to NDVI with a threshold of 1.5 showed reliable accuracy 35.47% with a k‐value of 0.20. However, one of the reasons for the accuracy error was due to the difference between land‐use change and land‐cover change. The actual rate of land‐cover change deforestation was 32% on the administrative information. The other reason was a 7.52% error extraction of the forest management area. Finally, considering the deforestation of the changed land‐cover region (GIS deforestation2 and RS deforestation, the highest accuracy was observed at the NDVI threshold value interval of 2 and showed an extraction rate and index of 61.2% and 0.23, respectively. In comparison with the case of applying GIS deforestation I, it showed 36.7% and 0.03 improvements. The MRV monitoring system based on the GIS and Remote Sensing techniques would enable the monitoring of larger size areas regularly and with high reliability.

  10. XPG rs2296147 T>C polymorphism predicted clinical outcome in colorectal cancer.

    Wang, Fang; Zhang, Shao-Dan; Xu, Hong-Mei; Zhu, Jin-Hong; Hua, Rui-Xi; Xue, Wen-Qiong; Li, Xi-Zhao; Wang, Tong-Min; He, Jing; Jia, Wei-Hua

    2016-03-01

    Xeroderma pigmentosum group G (XPG), one of key components of nucleotide excision repair pathway (NER), is involved in excision repair of UV-induced DNA damage. Single nucleotide polymorphisms (SNPs) in the XPG gene have been reported to associate with the clinical outcome of various cancer patients. We aimed to assess the impact of four potentially functional SNPs (rs2094258 C>T, rs2296147 T>C, rs751402 G>A, and rs873601 G>A) in the XPG gene on prognosis in colorectal cancer (CRC) patients. A total of 1901 patients diagnosed with pathologically confirmed CRC were genotyped for four XPG polymorphisms. Cox proportional hazards model analysis controlled for several confounding factors was conducted to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Of the four included SNPs, only rs2296147 was shown to significantly affect progression-free survival (PFS) in CRC. Patients carrying rs2296147 CT/TT genotype had a significantly shorter median 10 years PFS than those carrying CC genotype (88.5 months vs. 118.1 months), and an increased progression risk were observed with rs2296147 (HR = 1.324, 95% CI = 1.046-1.667). Moreover, none of the four SNPs were associated with overall survival. In conclusion, our study showed that XPG rs2296147 CT/TT variants conferred significant survival disadvantage in CRC patients in term of PFS. XPG rs2296147 polymorphism could be predictive of unfavorable prognosis of CRC patients. PMID:26887052

  11. Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?

    Bertuzzi, Rômulo; Pasqua, Leonardo A.; Bueno, Salomão; Lima-Silva, Adriano Eduardo; Matsuda, Monique; Marquezini, Monica; Saldiva, Paulo H.

    2014-01-01

    The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 ...

  12. Validation of the Official Slovak Version of the Unified Dyskinesia Rating Scale (UDysRS)

    Matej Skorvanek; Michal Minar; Milan Grofik; Katarina Kracunova; Vladimir Han; Frantisek Cibulcik; Jan Necpal; Ladislav Gurcik; Peter Valkovic

    2015-01-01

    After successful clinimetric testing of the Unified Dyskinesia Rating Scale (UDysRS), a program for translation and validation of non-English versions of the UDysRS was initiated. The aim of this study was to validate and confirm the factor structure of the Slovak translation of the UDysRS. We examined 251 patients with Parkinson’s disease and dyskinesia using the Slovak version of the UDysRS. The average age of our sample was 65.2 ± 9.2 years and average disease duration was 10.9 ± 5.0 years...

  13. A Combination of CD28 (rs1980422 and IRF5 (rs10488631 Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

    Lucia Vernerova

    Full Text Available The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA and redundancy analysis (RDA.A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601, STAT4 G/T (rs7574865, CTLA4 A/G (rs3087243, TRAF1/C5 A/G (rs3761847, IRF5 T/C (rs10488631, TNFAIP3 C/T (rs5029937, AFF3 A/T (rs11676922, PADI4 C/T (rs2240340, CD28 T/C (rs1980422, CSK G/A (rs34933034 and FCGR3A A/C (rs396991, rheumatoid factor (RF, anti-citrullinated protein antibodies (ACPA and clinical status was analysed using the LDA and RDA.HLA-DRB1, PTPN22, STAT4, IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. The correlation between RA diagnosis and the explanatory variables in the model was 0.328 (Trace = 0.107; F = 13.715; P = 0.0002. The risk variants of IRF5 and CD28 genes were found to be common determinants for seropositivity in RDA, while positivity of RF alone was associated with the CTLA4 risk variant in heterozygous form. The correlation between serologic status and genetic determinants on the 1st ordinal axis was 0.468, and 0.145 on the 2nd one (Trace = 0.179; F = 6.135; P = 0.001. The risk alleles in AFF3 gene together with the presence of ACPA were associated with higher clinical severity of RA.The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.

  14. Association between Insulin-Like Growth Factor 1 Gene rs12423791 or rs6214 Polymorphisms and High Myopia: A Meta-Analysis.

    Lan Guo

    Full Text Available To evaluate the association of insulin-like growth factor 1 gene rs12423791 and rs6214 polymorphisms with high myopia.An electronic search was conducted on PubMed, Embase, the Cochrane Library and the Chinese Biological Abstract Database for articles published prior to May 6, 2014. A meta-analysis was performed using Revman 5.1 and Stata 12.0, and the odds ratios with 95% confidence intervals were calculated in fixed or random effects models based on the results of the Q test. The subgroup analysis was conducted on the basis of the various regions, the sensitivity analysis was also performed to evaluate the stability of the results, and the publication bias was evaluated by a funnel plot and Egger's linear regression analysis.This comprehensive meta-analysis included 2808 high myopia patients and 2778 controls from five unrelated studies. The results demonstrated that the significant association was not present in any genetic models between IGF-1 rs12423791 or rs6214 and high myopia. However, subgroup analysis indicated that rs12423791 polymorphism was associated with high myopia in the Chinese populations in the allelic contrast model (C vs. G: OR=1.24, 95% CI=1.04-1.48 in the fixed-effects model, the dominant model (CC+CG vs. GG: OR=1.40, 95% CI=1.16-1.69 in the fixed-effects model, and the codominant model (CG vs. GG: OR=1.37, 95% CI= 1.12-1.68 in the fixed-effects model. Additionally, none of the individual studies significantly affected the association between IGF-1 rs12423791 and high myopia, according to sensitivity analysis.This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.

  15. Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

    Linhong Yuan; Jinmeng Liu; Li Dong; Can Cai; Sisi Wang; Bo Wang; Rong Xiao

    2015-01-01

    Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer’s disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in old Chinese adults, a community-based cross-sectional study was carried out in 477 Chinese adults ag...

  16. Lack of association of two common polymorphisms rs2910164 and rs11614913 with susceptibility to hepatocellular carcinoma: a meta-analysis.

    Zhongxia Wang

    Full Text Available BACKGROUND: Single nucleotide polymorphisms (SNPs in microRNA-coding genes may participate in the process of carcinogenesis by altering the expression of tumor-related microRNAs. It has been suggested that two common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to hepatocellular carcinoma (HCC. However, published results are inconsistent and inconclusive. In the present study, we performed a meta-analysis to systematically summarize the possible association between the two SNPs and the risk for HCC. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs11614913 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with the two polymorphisms was estimated by pooled odds ratios (ORs and 95% confidence intervals (95% CIs. 5 studies on rs2910164 and 4 studies on rs11614913 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk for HCC in all genetic models. Similarly, subgroup analysis in Chinese population showed no association between the two SNPs and the susceptibility to HCC. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

  17. NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.

    Zhao, Ying; Liu, Sheng-Li; Xie, Jian; Ding, Mao-Qian; Lu, Meng-Zhu; Zhang, Lan-Fang; Yao, Xiu-Hua; Hu, Bai; Lu, Wen-Sheng; Zheng, Xiao-Dong

    2016-01-01

    Keloids are abnormally raised fibroproliferative lesions that usually occur following cutaneous traumas. Recently, a large-scale genome-wide association study (GWAS) has identified multiple single nucleotide polymorphisms (SNPs) in three genetic loci that are associated with keloids in Japanese population. Subsequently, two reported loci 1q41 (rs873549 and rs1442440) and 15q21.3 (rs2271289) for keloids were confirmed in selected Chinese population. The association of these SNPs with clinical features of keloids, has not yet been studied. To explore the role of these SNPs in the pathogenesis of keloids, we performed a case-controlled study in another independent Chinese Han population to analyze the correlation between 4 SNPs (rs873549, rs2118610, rs1511412, rs2271289) and keloids phenotypes. 309 keloids patients and 1080 control subjects were included. The results showed that, in the dominant mode of inheritance, the minor allele T of SNP rs2271289 had significantly higher odd ratios (ORs) in the severe keloid group compared with both the controls and the mild keloid group. The ORs were maintained after Bonferroni's correction (OR: 4.09, 95% CI: 1.78-9.37, P-value 3.25E-04). The ratio of the severe: mild OR for rs2271289 (dominant model) is (4.73/1.84=2.57). Similar associations in SNP rs2271289 were seen for groups with no family history and multiplesite compared with the control groups. No associations between keloid number, family history or severity relative to the controls were observed for the other three SNPs. Our data support that rs2271289 is strongly associated with severe keloids and might contribute to the complexity of clinical features of keloids. PMID:27158346

  18. Intake of fat and fiber-rich foods according to socioeconomic status: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Consumo de alimentos com alto teor de gordura e fibras entre adolescentes, segundo posição socioeconômica: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Marilda B. Neutzling

    2010-10-01

    Full Text Available This study describes the food intake of adolescents participating in the 1993 birth cohort from Pelotas, Southern Brazil, according to socioeconomic position. We carried out a cross-sectional analysis of data collected in the 2004-2005 follow-up visit. Food intake in the previous year was evaluated using the Block questionnaire. Socioeconomic status was evaluated based on an assets index, divided into quintiles. Foods with the highest frequency of daily intake were white bread (83%, butter or margarine (74.6%, beans (66.4% and milk (48.5%. Intake of butter or margarine, bread, and beans was more frequent among poorer adolescents, and the inverse was true for milk. Intake of fruits and vegetables was low in all socioeconomic strata, but particularly low among the poor. In early adolescence, all socioeconomic groups showed high consumption of foods rich in fat and low consumption of foods rich in fiber.O estudo descreve alimentos consumidos por adolescentes pertencentes à coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil, conforme o nível socioeconômico. Foi feita uma análise transversal com dados coletados no acompanhamento de 2004-2005. A freqüência alimentar no último ano foi avaliada pelo questionário Block. A posição socioeconômica foi verificada com base no índice de bens, dividido em quintis. Os alimentos mais consumidos diariamente foram: pão branco (83%, manteiga ou margarina (74,6%, feijão (66,4% e leite (48,5%. O consumo de manteiga ou margarina, pão e feijão foram mais freqüentes entre adolescentes pertencentes ao primeiro (menor quintil do índice de bens, e o consumo de leite foi maior no último quintil. Frutas, vegetais e salada verde tiveram baixo consumo principalmente entre os mais pobres. Todos os grupos socioeconômicos apresentaram consumo elevado de alimentos ricos em gordura e baixo consumo de alimentos ricos em fibra.

  19. DSP network control system based on RS485%基于RS485总线的DSP网络控制系统设计

    沈文杰; 陈文清; 陈伟

    2011-01-01

    To make reliable communication between multiple industrial production data in a computer control system, and to achieve real time control, the RS485 network control system is proposed in this paper based on TMS320LF2407A. The design of DSP network control system is introduced. The hardware of field control note was designed using RS485 bus, and the detailed software implementation is described. The RS485 reliable dato communications is achieved between the PC and the bottom of the controller's. It verified their network control targets through the production site.%为了使工业生产计算机控制系统中多种数据之间有可靠通讯,满足过程实时控制的要求,提出了一种基于DSP的网络控制系统的设计方案,介绍了DSP网络控制系统的总体设计思路,运用RS485总线技术对现场控制节点进行硬件设计并对RS485通讯软件的实现进行了详细地分析,实现了上位机与底层控制器之间的RS485数据的可靠通讯,通过生产现场调试验证了网络控制指标.

  20. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

    Pharoah, Paul D P; Palmieri, Rachel T; Ramus, Susan J;

    2011-01-01

    PURPOSE: An assay for the single nucleotide polymorphism (SNP) rs61764370 has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'UTR miRNA binding site of the KRAS oncogene, and is a cand...

  1. On Best Approximations from RS-sets in Complex Banach Spaces

    Chong LI

    2005-01-01

    The concept of an RS-set in a complex Banach Space is introduced and the problem of best approximation from an RS-set in a complex space is investigated. Results consisting of characterizations, uniqueness and strong uniqueness are established.

  2. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Herve; Wesselsl, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together wit

  3. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility

    Guangyuan Chen

    2015-05-01

    Full Text Available Large-scale genome-wide association studies (GWAS have revealed that rs10757278 polymorphism (or its proxy rs1333049 on chromosome 9p21 is associated with myocardial infarction (MI susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR = 1.29, 95% confidence interval (CI 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.

  4. Uso de métodos anticoncepcionais e adequação de contraceptivos hormonais orais na cidade de Pelotas, Rio Grande do Sul, Brasil: 1992 e 1999

    Juvenal Soares Dias-da-Costa

    2002-02-01

    Full Text Available Realizou-se um estudo transversal de base populacional, com o objetivo de verificar a utilização de métodos contraceptivos e adequação do emprego de anticoncepcionais orais pelas mulheres de 20 a 49 anos, residentes na zona urbana da cidade de Pelotas. Os resultados foram comparados com outro estudo transversal de base populacional, realizado em 1992. Utilizou-se amostragem por conglomerados, incluindo-se 766 mulheres com idade entre 20 e 49 anos. Do total de mulheres, 495 (64,6% utilizavam algum método contraceptivo, sendo mais freqüentemente empregados: anticoncepcionais orais (55,4%, ligadura tubária (22,2%, preservativo (10,5% e dispositivo intra-uterino (7,7%. Entre as usuárias de anticoncepcionais orais, verificou-se que 22,2% apresentavam contra-indicação para seu emprego. O uso incorreto associou-se significativamente à idade, mas foi semelhante entre as classes sociais. Comparando os resultados com aqueles do estudo anterior, destaca-se a redução no emprego de anticoncepcionais orais, e maior freqüência de ligaduras, uso de preservativos e dispositivos intra-uterinos.

  5. Can mothers rely on the Brazilian health system for their deliveries? An assessment of use of the public system and out-of-pocket expenditure in the 2004 Pelotas Birth Cohort Study, Brazil

    Bertoldi Andréa D

    2008-03-01

    Full Text Available Abstract Background In a country where comprehensive free health care is provided via a public health system (SUS, an unexpected high frequency of catastrophic out-of-pocket expenditure has been described. We studied how deliveries were financed among mothers of a birth cohort and whether they were an important source of household out-of-pocket expenditure. Methods All deliveries occurring in the city of Pelotas, Brazil, during 2004, were recruited for a birth cohort study. All mothers were interviewed just after birth and three months later. Comprehensive data on the pregnancy, delivery, birth conditions and newborn health were collected, along with detailed information on expenses related to the delivery. Results The majority of the deliveries (81% were financed by the public health system, a proportion that increased to more than 95% among the 40% poorest mothers. Less than 1% of these mothers reported some out-of-pocket expenditure. Even among those mothers covered by a private health plan, nearly 50% of births were financed by the SUS. Among the 20% richest, a third of the deliveries were paid by the SUS, 50% by private health plans and 17% by direct payment. Conclusion The public health system offered services in quantity and quality enough to attract even beneficiaries of private health plans and spared mothers from the poorest strata of the population of practically any expense.

  6. Association of polymorphisms of rs179247 and rs12101255 in thyroid stimulating hormone receptor intron 1 with an increased risk of Graves' disease: A meta-analysis.

    Gong, Jing; Jiang, Shu-Jun; Wang, Ding-Kun; Dong, Hui; Chen, Guang; Fang, Ke; Cui, Jin-Rui; Lu, Fu-Er

    2016-08-01

    The polymorphisms of thyroid stimulating hormone receptor (TSHR) intron 1 rs179247 and rs12101255 have been found to be associated with Graves' disease (GD) in genetic studies. In the present study, we conducted a meta-analysis to examine this association. Two reviewers systematically searched eligible studies in PubMed, Web of Science, Embase and China Biomedical Literature Database (CBM). A meta-analysis on the association between GD and TSHR intron 1 rs179247 or rs12101255 was performed. The odd ratios (OR) were estimated with 95% confidence interval (CI). Meta package in R was used for the analyses. Seven articles (13 studies) published between 2009 and 2014, involving 5754 GD patients and 5768 controls, were analyzed. The polymorphism of rs179247 was found to be associated with an increased GD risk in the allele analysis (A vs. G: OR=1.40, 95% CI=1.33-1.48) and all genetic models (AA vs. GG: OR=1.94, 95% CI=1.73-2.19; AA+AG vs. GG: OR=1.57, 95% CI=1.41-1.74; AA vs. AG+GG: OR=1.54, 95% CI=1.43-1.66). The site rs12101255 also conferred a risk of GD in the allele analysis (T vs. C: OR=1.50, 95% CI=1.40-1.60) and all genetic models (TT vs. CC: OR=2.22, 95% CI=1.92-2.57; TT+TC vs. CC: OR=1.66, 95% CI=1.50-1.83; TT vs. TC+CC: OR=1.74, 95% CI=1.53-1.98). Analysis of the relationship between rs179247 and Graves' ophthalmopathy (GO) showed no statistically significant correlation (A vs. G: OR=1.02, 95% CI=0.97-1.07). Publication bias was not significant. In conclusion, GD is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and GO. PMID:27465319

  7. Association of polymorphisms hOGG1 rs1052133 and hMUTYH rs3219472 with risk of nasopharyngeal carcinoma in a Chinese population

    Xie Y

    2016-02-01

    Full Text Available Ying Xie,2 Yuan Wu,3 Xunzhao Zhou,3 Mengwei Yao,3 Sisi Ning,3 Zhengbo Wei1 1Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, 2Guangxi Key Laboratory for High-Incidence Tumor Prevention and Treatment, Experimental Center of Medical Science of Guangxi Medical University,3Graduate School of Guangxi Medical University, Nanning, People’s Republic of China Abstract: This case–control study investigates the possible relationships between the single-nucleotide polymorphisms rs1052133 in the human 8-oxoguanine DNA glycosylase 1 (hOGG1 gene and rs3219472 in the human MutY glycosylase homologue (hMUTYH gene and the risk of nasopharyngeal carcinoma (NPC. The two polymorphisms were genotyped in 488 unrelated NPC patients and 573 cancer-free controls. Genotype GG at rs1052133 was associated with significantly lower NPC risk than genotypes GC + CC (odds ratio [OR] 0.770, 95% confidence interval [CI] 0.595–0.996, P=0.012. In subgroup analyses, subjects with genotype GG at rs1052133 were at lower risk of NPC than those with GC or CC among individuals older than 40 years (OR 0.706, 95% CI 0.524–0.950, women (OR 0.571, 95% CI 0.337–0.968, and those with no smoking history (OR 0.634, 95% CI 0.463–0.868. No significant association was seen between polymorphisms at hMUTYH rs3219472 and the risk of NPC. However, gene–gene interaction analysis showed that subjects with genotype CC at rs1052133 and genotype AA at rs3219472 (CC/AA were at 2.887-fold higher risk of NPC than those with GG/GG, 3.183-fold higher risk than those with GG/GA, and 3.392-fold higher risk than those with GG/AA. Our results suggest that hOGG1 rs1052133 polymorphism may play an important role in NPC pathogenesis, especially among women, >40 years old, and those with no smoking history. The hMUTYH rs3219472 polymorphism may interact with hOGG1 rs1052133 polymorphism to influence susceptibility to NPC. Keywords: nasopharyngeal

  8. do município de Porto Alegre-RS

    Márcia Cançado Figueiredo

    2008-01-01

    Full Text Available This study was evaluated of self-perceptions and knowledge about oral health of deprived population, and previously the introduction of an Oral Health Promotion Program. It is about a cross-sectional and descriptive study made with people who go to the Health Basic Units (HBU Timbaúva, located in Mário Quintana’s Quarter, in Porto Alegre municipality - RS, in 2007, with data collected from a questionnaire structured with closed questions, previously tested in a pilot study. The questionnaires were filled by 185 parents or responsibles of children enrolled in the school of the community. The results showed that just 31, 98% went already to the dentist because of tooth pain. About the self perception linked to the oral health, 63, 78% had already experience of tooth decay, 40% refer gingival blood to brush and 32, 43% had already a permanent tooth extracted. 95,13% said that they have a toothbrush at home and 9,73% share this instrument of oral hygiene with the family. About the usage of dentifrice 98, 37% use it and 50, 81% eat sweets. Therefore, strategies of health promotion should be based on previous knowledge and self-perceptions of health in order to the actions in education in oral health may generate better health conditions.

  9. Pentatomids associated with different forest species in Itaara, RS, Brazil

    Ervandil Corrêa Costa

    2010-03-01

    Full Text Available The objective of this study was to determine qualitatively and quantitatively the pentatomid fauna associated with the canopy of different native species during the period from September 2005 to September 2006. Insects were collected from among nine botanical species: Gochnatia polymorpha (Less. (cambará, Eugenia uniflora Berg. (pitangueira, Acca selowiana (Berg Burret (goiaba-da-serra, Psidium cattleianum Sabine (araçá, Baccharis spp., Solanaum mauritianum Scop. (fumo-bravo, Micanea cinerascens Miq. (passiquinho, Calliandra brevipes Bhent. (caliandra, and Schinus molle L. (aroeira located at Rodolfo da Costa Dam in Itaara, RS, Brazil. Samples were taken every two weeks with a conical funnel made of tin plate (2mm, 70cm in diameter at the rim and 63cm in height. One sample per botanical species for each sampling date was taken, by shaking the branches, ten times over the funnel. Samples were sent to the Entomology Laboratory of the Crop Protection Department of the Federal University of Santa Maria, where the material was analyzed. A total of nine Pentatomidae species were identified. Edessa rufomarginata (De Geer, 1773 was the species of highest ocurrence followed by Thyanta humilis (Bergroth, 1891. The botanical species S. mauritianum presented the greatest number of Pentatomidae species, with an occurrence of 26.9%.

  10. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

    Raquel López-Mejías; Fernanda Genre; Sara Remuzgo-Martínez; Montserrat Robustillo-Villarino; Mercedes García-Bermúdez; Javier Llorca; Alfonso Corrales; Carlos González-Juanatey; Begoña Ubilla; Miranda-Filloy, José A.; Verónica Mijares; Trinitario Pina; Ricardo Blanco; Alegre-Sancho, Juan J.; Ramírez Huaranga, Marco A.

    2015-01-01

    OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subcl...

  11. Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

    Piotr Janik

    Full Text Available Gilles de la Tourette syndrome (GTS is a neurodevelopmental disorder characterized by motor and vocal tics. Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics. There are reciprocal antagonistic interactions between adenosine and dopamine transmission. The aim of the study was to analyze the association of two polymorphisms, rs2228079 in ADORA1 and rs5751876 in ADORA2A, with the risk of GTS and co-morbid disorders.A total of 162 Polish GTS patients and 270 healthy persons were enrolled in the study. Two polymorphisms were selected on the basis of knowledge of SNPs frequencies in ADORA1 and ADORA2A. Chi-square test was used for allelic and genotypic association studies. Association of genotypes with age of tic onset was analyzed with Mann-Whitney test. Multivariate logistic regression was used to find independent predictors of GTS risk.We found that the risk of GTS was associated with rs2228079 and rs5751876 polymorphisms. The GG+GT genotypes of rs2228079 in ADORA1 were underrepresented in GTS patients (p = 0.011, whereas T allele of rs5751876 in ADORA2A was overrepresented (p = 0.017. The GG genotype of rs2228079 was associated with earlier age of tic onset (p = 0.046. We found also that the minor allele G of rs2228079 was more frequent in GTS patients with depression as compared to the patients without depression (p = 0.015. Also the genotype GG was significantly more frequent in patients with obsessive compulsive disorder/behavior (OCD/OCB, p = 0.021 and depression (p = 0.032, as compared to the patients without these co-morbidities. The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022, and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045.ADORA1 and ADORA2A variants are associated with the risk of GTS, co-morbid disorders, and may affect the age of tic onset.

  12. Cephalopods in neuroscience: regulations, research and the 3Rs.

    Fiorito, Graziano; Affuso, Andrea; Anderson, David B; Basil, Jennifer; Bonnaud, Laure; Botta, Giovanni; Cole, Alison; D'Angelo, Livia; De Girolamo, Paolo; Dennison, Ngaire; Dickel, Ludovic; Di Cosmo, Anna; Di Cristo, Carlo; Gestal, Camino; Fonseca, Rute; Grasso, Frank; Kristiansen, Tore; Kuba, Michael; Maffucci, Fulvio; Manciocco, Arianna; Mark, Felix Christopher; Melillo, Daniela; Osorio, Daniel; Palumbo, Anna; Perkins, Kerry; Ponte, Giovanna; Raspa, Marcello; Shashar, Nadav; Smith, Jane; Smith, David; Sykes, António; Villanueva, Roger; Tublitz, Nathan; Zullo, Letizia; Andrews, Paul

    2014-03-01

    Cephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the about 700 extant species of "live cephalopods" became regulated within the European Union by Directive 2010/63/EU on the "Protection of Animals used for Scientific Purposes", giving cephalopods the same EU legal protection as previously afforded only to vertebrates. The Directive has a number of implications, particularly for neuroscience research. These include: (1) projects will need justification, authorisation from local competent authorities, and be subject to review including a harm-benefit assessment and adherence to the 3Rs principles (Replacement, Refinement and Reduction). (2) To support project evaluation and compliance with the new EU law, guidelines specific to cephalopods will need to be developed, covering capture, transport, handling, housing, care, maintenance, health monitoring, humane anaesthesia, analgesia and euthanasia. (3) Objective criteria need to be developed to identify signs of pain, suffering, distress and lasting harm particularly in the context of their induction by an experimental procedure. Despite diversity of views existing on some of these topics, this paper reviews the above topics and describes the approaches being taken by the cephalopod research community (represented by the authorship) to produce "guidelines" and the potential contribution of neuroscience research to cephalopod welfare. PMID:24385049

  13. do município de Torres/RS

    Simone Guerra Vidal

    2006-01-01

    Full Text Available This study it had as objective to evaluate the present fluoride concentration in the water of supply fluoridation in Torres – RS, for a period of 7 months. The samples had been collected monthly in 8 different points of the city, which also represented the population supplied and in the treatment station (ETA. The method used in the analysis of the samples was the ion-specific electrode, being that to each evaluation the device was calibrated. The results had demonstrated that it had an oscillation in the fluorine concentration that varied of 0,29 the 0,91 ppmF/L during the evaluated period. The medium of the fluoride concentration between all the samples was 0,61 ppmF/L and the mediana was 0,62 ppmF/L. In the ETA it was observed that in 71,4% of the collected months the level of the fluoride concentration was considered inadequate, being that the lesser joined value was 0,33 ppmF/L and the greater was of 0,91 ppmF/L. Of the 60 collected samples, 26 (43,3% had presented the adequate fluoride concentration (between 0,6 and 0,9 ppmF/L and 34 (56,7% had presented inadequate levels. In this study we can conclude that it had an oscillation of the fluoridation in the water of supplying of the Torres, what it can intervene with the benefits waited for the fluoridation in the studied population.

  14. Mysterious a6-containing nAChRs: function, pharmacology, and pathophysiology

    Ke-chun YANGU; Guo-zhang JIN; Jie WU

    2009-01-01

    Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling. Thus far, nine alpha (a2-alO) and three beta ((32, (33, and (34) subunits have been identified in the CNS, and these subunits assemble to form a diversity of functional nAChRs. Although a4(32- and a7-nAChRs are the two major functional nAChR types in the CNS, a6*-nAChRs are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. Recently, functional and pharmacological profiles of a6*-nAChRs have been assessed with the use of a6 subunit blockers such as a-conotoxin Mil and PIA, and also by using a6 subunit knockout mice. By modulating DA release in the nucleus accumbens (NAc) and modulating GABA release onto DAergic neurons in the ventral tegmental area (VTA), a6*-nAChRs may play important roles in the mediation of nicotine reward and addiction. Furthermore, a6*-nAChRs in the nigrostriatal DAergic system may be promising targets for selective preventative treatment of Parkinson's disease (PD). Thus, a6*-nAChRs may hold promise for future clinical treatment of human disorders, such as nicotine addiction and PD. In this review, we mainly focus on the recent advances in the understanding of ct6*-nAChR function, pharmacology and pathophysiology.

  15. TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas.

    Nencha, Umberto; Rahimian, Amithys; Giry, Marine; Sechi, Andrea; Mokhtari, Karima; Polivka, Marc; Schmitt, Yohann; Di Stefano, Anna-Luisa; Alentorn, Agusti; Labussière, Marianne; Sanson, Marc

    2016-02-01

    TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations, tumor genomic profile and the impact on prognosis. The TERTp and rs2853669 statuses were determined and confronted with the outcome and molecular profile, i.e., loss of chromosome 10q, CDKN2A deletion, IDH mutation, EGFR amplification, MGMT promoter methylation. 651 glioblastomas were selected (sex ratio = 1.35, median age 60.4 years, median survival 13.5 months). The TERTp mutation found in 481 patients (74 %) was independent from rs2853669 genotypes. TERTp mutation, but not rs2853669 status, was associated with older age (61.4 vs. 52.8 years). rs2853669 status had no impact on overall survival (OS) either in mutated TERTp or wild-type TERTp. Neither rs2736100 (TERT, 5q15.33) nor rs192011116 (TERC, 3q26.2) status had any impact on survival or showed any association with a TERTp mutation. The TERTp mutation was associated with EGFR amplification chromosome 10q loss, CDKN2A deletion and IDH wt. EGFR amplification was associated with a better outcome in TERTp mutated GBM, and a worse outcome in TERTp WT. This study-the largest analyzing the TERTp mutation and the rs2853669 polymorphism-fails to find any prognostic impact of rs2853669. It confirms the dual prognostic impact of EGFR amplification depending on TERTp status. PMID:26608520

  16. The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers

    2010-01-01

    Abstract The rs3834129 polymorphism, in the promoter of CASP8 gene, has been recently reported as associated with breast cancer risk in the general population, with the minor allele del having a protective effect. Some of the genetic variants found associated with breast cancer risk were reported as risk modifiers in individuals with mutations in BRCA1 and BRCA2 genes. Here, we tested the effect of the rs3834129 del allele on breast cancer risk in BRCA mutation carriers. The rs3834...

  17. Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Hervé; Wessels, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together with data reported previously for strain NEM316, the results reveal a conserved 39-gene CsrRS regulon. In vitro phosphorylation-dependent binding of recombinant CsrR to promoter regions of both positi...

  18. Single nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

    Greenberg, Alexandra J.; Lee, Adam M.; Daniel J. Serie; McDonnell, Shannon K; Cerhan, James R.; Liebow, Mark; Larson, Dirk R.; Colby, Colin L.; Norman, Aaron D.; Kyle, Robert A.; Rajkumar, S. Vincent; Diasio, Robert B.; Susan L Slager; Vachon, Celine M.

    2012-01-01

    Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor to multiple myeloma (MM). Though several genetic variants have been identified for MM, none have been identified for MGUS. Recently, Broderick et al. conducted a GWAS of MM and identified three novel loci at 3p22.1 (rs1052501), 7p15.3 (rs4487645) and 2p23.3 (rs6746082) associated with MM risk. We examined the association of these variants with MGUS in a clinic-based case-control study of 391 MGUS cases and 3...

  19. Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects

    Yu XJ

    2016-04-01

    Full Text Available Xiongjie Yu,1,* Yanli Li,2,* Yuandong Yu,1 Jinhua Lei,1 Guoxing Wan,1 Fengjun Cao1 1Department of Oncology, 2Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, People’s Republic of China *These authors contributed equally to this work Background: Previous studies have investigated the associations between the common polymorphisms in FAS/FASL genes and lung cancer risk; however, the results remain inconsistent and inconclusive. Hence, we performed a meta-analysis to reassess the relationships between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer. Methods: Eligible studies retrieved by an electronic search were pooled to calculate the strength of the associations using the odds ratio (OR and 95% confidence interval (95% CI. Results: A total of 13 case–control studies involving 39,736 subjects (9,237 cases and 10,838 controls on FAS rs2234767 and 8,957 cases and 10,704 controls on FASL rs763110 were included in the meta-analysis. The results showed a significant association between FAS rs2234767 polymorphism and increased risk of lung cancer (A vs G: OR =1.07, 95% CI =1.01–1.13; AA vs GG: OR =1.23, 95% CI =1.06–1.43; AA vs GA + GG: OR =1.24, 95% CI =1.08–1.43. Similar association was also observed in Asian population (AA vs GA + GG: OR =1.30, 95% CI =1.01–1.67 and in the studies with large sample size (A vs G: OR =1.07, 95% CI =1.00–1.14; AA vs GG: OR =1.30, 95% CI =1.07–1.58. However, no significant association between FASL rs763110 polymorphism and lung cancer risk was found other than in the Asian population (CC vs TC + TT: OR =1.35, 95% CI =1.01–1.80. Conclusion: The meta-analysis indicated that FAS rs2234767 polymorphism was significantly associated with an increased risk of lung cancer and FASL rs763110 polymorphism may not contribute to susceptibility to lung cancer other than in Asian population. Keywords: FAS, FAS ligand, polymorphism, lung cancer, meta

  20. Deracemizacija (RS)-1-[(4-metilselanil)fenil]etanola i (RS)-1-[(4-etilselanil)fenil]etanola s pomoću sojeva Aspergillus terreus

    Fernandes Assis, Leonardo; Kagohara, Edna; Takeo Omori, Álvaro; Valdir Comasseto, João; Helgueira Andrade, Leandro; Meleiro Porto, André Luiz

    2007-01-01

    Sojevi plijesni Aspergillus terreus URM 3371 i A. terreus CCT 4083, izolirani u Brazilu, katalizirali su deracemizaciju (RS)-1-[(4-metilselanil)fenil]etanola (1) i (RS)-1-[(4-etilselanil)fenil]etanola (2). Upotrijebljene su cijele stanice plijesni različite mase (1-5 g), pri različitoj pH-vrijednosti (4 i 7) i temperaturi biotransformacije (20 i 32 °C), uz dodatak raznih aditiva (etanol, butanol, propanol i cikloheksanol) radi poboljšanja prinosa i selektivnosti proizvoda. Soj A. terreus URM ...

  1. Association between Insulin-Like Growth Factor 1 Gene rs12423791 or rs6214 Polymorphisms and High Myopia: A Meta-Analysis

    Guo, Lan; Du, Xueying; Lu, Ciyong; Zhang, Wei-Hong

    2015-01-01

    Objective To evaluate the association of insulin-like growth factor 1 gene rs12423791 and rs6214 polymorphisms with high myopia. Methods An electronic search was conducted on PubMed, Embase, the Cochrane Library and the Chinese Biological Abstract Database for articles published prior to May 6, 2014. A meta-analysis was performed using Revman 5.1 and Stata 12.0, and the odds ratios with 95% confidence intervals were calculated in fixed or random effects models based on the results of the Q te...

  2. Investigating the Correlation between rs1049305 and ‏rs10244884 Polymorphisms of AQP-1 Gene and Menorrhagia ‎in Adolescents

    S Madani

    2014-02-01

    Results: Regarding ‏‎rs1049305, the C minor allele showed more frequency in patients' group‏ (0.47 vs. 0.37.‎‎ The results revealed that GG genotype presents less probable risk ‎for menorrhagia. ‎‎ rs10244884‎ also shows the same frequency. Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.

  3. ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes

    Shah, Viral N; Cheema, Balneek Singh; Sharma, Rajni; Khullar, Madhu; Kohli, Harbir Singh; Ahluwalia, Tarun Veer Singh; Mohan, Viswanathan; Bhansali, Anil

    Patients with type 2 diabetes (T2DM) are usually obese and concurrent obesity results into activation of the renin-angiotensin-system (RAS) which is a risk factor for diabetic nephropathy (DN). Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACβ) gene, which is involved in fatty...... acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue, polymorphism with DN have not been studied earlier. The present study was designed with the aim to examine the association of an ACACβ (rs2268388) and AGTR1 (rs5186) gene polymorphism with...

  4. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil

    Giancarlo Bacchieri

    2005-10-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.

  5. SHRIMP U-Pb age and high temperature conditions of the collisional metamorphism in the Várzea do Capivarita Complex: Implications for the origin of Pelotas Batholith, Dom Feliciano Belt, southern Brazil

    Philipp, Ruy Paulo; Bom, Francisco Molina; Pimentel, Márcio Martins; Junges, Sérgio Luiz; Zvirtes, Gustavo

    2016-03-01

    The Várzea do Capivarita Complex is composed of pelitic gneisses with subordinate calc-silicate rock, marble and rare quartzite. It is part of the neoproterozoic Dom Feliciano Belt, in southern Brazil. The gneisses are associated to veins and tabular leucogranite bodies, which are the product of anatexis of the pelitic gneiss. The paragneisses of the Várzea do Capivarita Complex are tectonically juxtaposed to orthogneisses of the Arroio dos Ratos Complex. This complex is exposed as megaxenoliths in granites of the Encruzilhada do Sul Suite and as smaller fragments in the Quitéria and Cordilheira Granites, all part of the Pelotas Batholith. The metamorphic foliation is oriented to N30°W, with dips between 35 and 55° to the SW and mineral lineation is suborizontal with rake ranging from 15° to 30° and down dip to NW and SE, suggesting deformation associated with a transpressive system. Based on the paragenesis garnet-cordierite-sillimanite-biotite, metamorphism occurred at 720-820° C and pressure of 8-9 kbar, characterizing it as of intermediate pressure and high temperature series. Zircon grains of one sample of garnet-cordierite-sillimanite-biotite gneiss and one of peraluminous leucogranite was dated by the U-Pb SHRIMP method. The paragneiss metamorphic zircon yielded an age of 619 ± 4.3 Ma interpreted as an age of the main metamorphic event, whereas igneous zircon grains from the leucogranite indicates that magma crystallization took place at 620 ± 6.3 Ma. The main metamorphic foliation (S2) of the paragneiss and the leucogranite magmatic foliation (S0) are parallel to each other, indicating that they were formed during the same event. This suggests that anatexis of the paragneisses of the Várzea do Capivarite Complex generated the peraluminous leucogranites right after the climax of the collisional metamorphism.

  6. Preparation and characterization of ketoprofen loaded eudragit RS polymeric nanoparticles for controlled release

    Anh, Nguyen Tuan; Chi, Nguyen T.; Khai Tran, T.; Tuyen Dao, T. P.; Nhan Le, N. T.; Mau Chien, Dang; Hoai, Nguyen To

    2012-12-01

    Nanospheres containing ketoprofen (Keto) and polymer eudragit RS were prepared using an emulsion solvent evaporation method. The ultrasonic probe (VCX500, vibracell) was used as a tool to disperse oil phase into aqueous phase leading to water/oil emulsion. Nanoparticles were successfully prepared and their morphologies and diameters were confirmed by transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. The result showed that particles were spherical with submicron size. The particle size was dependent on the RS concentration, emulsification tools and the types of organic solvents. For the encapsulation ability, Keto-loaded RS nanoparticle showed 9.8% of Keto in nanoparticle, which was evaluated by high-performance liquid chromatography (HPLC). Moreover, the drug release behavior of Keto-loaded eudragit RS nanoparticle was also investigated in vitro at pH 7.4 and compared to referential profenid.

  7. Trails, RS2477, picpts-Project, Published in 2006, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts-Project'. Data by this publisher are often...

  8. Trails, RS2477, TransplanGood, Published in 2007, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2007. It is described as 'TransplanGood'. Data by this publisher are often...

  9. Trails, RS2477, UnimprovedRoadPictures, Published in 2004, Millard County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2004. It is described as 'UnimprovedRoadPictures'. Data by this publisher are...

  10. Trails, RS2477, ImprovedroadPictures, Published in 2005, Millard County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'ImprovedroadPictures'. Data by this publisher are...

  11. Trails, RS2477, centerlines-project, Published in 2006, Duchesne County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'centerlines-project'. Data by this publisher are...

  12. Trails, RS2477, UnimprovedRoad, Published in 2005, Millard County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'UnimprovedRoad'. Data by this publisher are often...

  13. Integrated Application of RS and GIS to Agriculture Land Use Planning

    2002-01-01

    This paper gives some guidelines of land use planning firstly.A framework of agriculture land use planning is designed based on land use suitability evaluation using integrated technologies of RS and GIS.Further work expected is also given.

  14. Preparation and characterization of ketoprofen loaded eudragit RS polymeric nanoparticles for controlled release

    Nanospheres containing ketoprofen (Keto) and polymer eudragit RS were prepared using an emulsion solvent evaporation method. The ultrasonic probe (VCX500, vibracell) was used as a tool to disperse oil phase into aqueous phase leading to water/oil emulsion. Nanoparticles were successfully prepared and their morphologies and diameters were confirmed by transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. The result showed that particles were spherical with submicron size. The particle size was dependent on the RS concentration, emulsification tools and the types of organic solvents. For the encapsulation ability, Keto-loaded RS nanoparticle showed 9.8% of Keto in nanoparticle, which was evaluated by high-performance liquid chromatography (HPLC). Moreover, the drug release behavior of Keto-loaded eudragit RS nanoparticle was also investigated in vitro at pH 7.4 and compared to referential profenid. (paper)

  15. Site-specific uv crosslinking of minihelix DNA and TrpRS from Bacillus subtilis

    2001-01-01

    In order to investigate the recognition mechanism and the relationship between structure and function of minihelix DNA with Tryptophanyl-tRNA Synthetase (TrpRS), TrpRS from Bacillus Subtilis was purified. Four minihelix DNAs were chemically synthesized and the photoreactive reagent s4T was incorporated into three of them at the positions of G73, T72 and T55 corresponding to tRNATrp.The apparatus for uv crossiinking was devised and the parameters for uv crosslinking were optimized. The results indicated that the G73 and T72 base of minihelix DNA interacted with TrpRS directly. The uv crosslinking reaction was improved by the dose of uv irradiation and the concentration of both TrpRS and minihelix DNA.``

  16. A family of RS domain proteins with novel subcellular localization and trafficking

    Kavanagh, Steven J.; Thomas C Schulz; Davey, Philippa; Claudianos, Charles; Russell, Carrie; Peter D. Rathjen

    2005-01-01

    We report the sequence, conservation and cell biology of a novel protein, Psc1, which is expressed and regulated within the embryonic pluripotent cell population of the mouse. The Psc1 sequence includes an RS domain and an RNA recognition motif (RRM), and a sequential arrangement of protein motifs that has not been demonstrated for other RS domain proteins. This arrangement was conserved in a second mouse protein (BAC34721). The identification of Psc1 and BAC34721 homologues in vertebrates an...

  17. The prostate cancer risk stratification (ProCaRS) project: Recursive partitioning risk stratification analysis

    Background: The Genitourinary Radiation Oncologists of Canada (GUROC) published a three-group risk stratification (RS) system to assist prostate cancer decision-making in 2001. The objective of this project is to use the ProCaRS database to statistically model the predictive accuracy and clinical utility of a proposed new multi-group RS schema. Methods: The RS analyses utilized the ProCaRS database that consists of 7974 patients from four Canadian institutions. Recursive partitioning analysis (RPA) was utilized to explore the sub-stratification of groups defined by the existing three-group GUROC scheme. 10-fold cross-validated C-indices and the Net Reclassification Index were both used to assess multivariable models and compare the predictive accuracy of existing and proposed RS systems, respectively. Results: The recursive partitioning analysis has suggested that the existing GUROC classification system could be altered to accommodate as many as six separate and statistical unique groups based on differences in BFFS (C-index 0.67 and AUC 0.70). GUROC low-risk patients would be divided into new favorable-low and low-risk groups based on PSA ⩽6 and PSA >6. GUROC intermediate-risk patients can be subclassified into low-intermediate and high-intermediate groups. GUROC high-intermediate-risk is defined as existing GUROC intermediate-risk with PSA >=10 AND either T2b/c disease or T1T2a disease with Gleason 7. GUROC high-risk patients would be subclassified into an additional extreme-risk group (GUROC high-risk AND (positive cores ⩾87.5% OR PSA >30). Conclusions: Proposed RS subcategories have been identified by a RPA of the ProCaRS database

  18. Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

    Zhang W

    2014-09-01

    Full Text Available Wenji Zhang,1,3,* Xuedong Li,2,* Tiantian Ye,3 Fen Chen,3 Shihui Yu,3 Jianting Chen,3 Xinggang Yang,3 Na Yang,2 Jinsong Zhang,2 Jinlu Liu,2 Weisan Pan,3 Jun Kong2 1Department of Pharmaceutics, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; 2Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang, People’s Republic of China; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China *These authors contributed equally to this work Abstract: This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU RS 100-coated nanostructured lipid carrier (NLC. The genistein encapsulated NLC (GEN-NLC was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from −7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (Papp compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use. Keywords

  19. The Common Variant rs11646213 Is Associated with Preeclampsia in Han Chinese Women

    Wan, Ji-Peng; Zhao, Han; Li, Tao; Li, Chang-Zhong; Wang, Xie-tong; Chen, Zi-Jiang

    2013-01-01

    Background Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. Methods A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP)...

  20. Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática = Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review

    Jacondino, Camila Bittencourt

    2014-01-01

    Conclusões: Os resultados sugerem que os OXTR rs53576 e rs2254298 estão associados a sintomas, temperamento depressivo e depressão. Contudo, é importante levar em consideração que esses polimorfismos não atuam de forma determinística, ou seja, são influenciados ou modulados por condições ambientais, que podem envolver fatores biopsicossociais, afetivos, étnicos e de gênero.

  1. Robust GRAPPA-Accelerated Diffusion-Weighted Readout-Segmented (RS)-EPI

    Holdsworth, Samantha J.; Skare, Stefan; Newbould, Rexford D.; Bammer, Roland

    2009-01-01

    Readout segmentation (RS-EPI) has been suggested as a promising variant to echo-planar imaging (EPI) for high-resolution imaging, particularly when combined with parallel imaging. This work details some of the technical aspects of diffusion-weighted (DW)-RS-EPI, outlining a set of reconstruction methods and imaging parameters that can both minimize the scan time and afford high-resolution diffusion imaging with reduced distortions. These methods include an efficient generalized autocalibratin...

  2. Faktor-Faktor Yang Mempengaruhi Kejadian Insomnia di Poliklinik Saraf RS DR. M. Djamil Padang

    Lydia Susanti

    2015-01-01

    Abstrak Faktor risiko seperti usia lanjut, jenis kelamin wanita, penyakit penyerta (depresi dan penyakit lain), status sosial ekonomi rendah menyebabkan insomnia. Penelitian mengenai prevalensi dan faktor-faktor yang mempengaruhi kejadian insomnia di Poliklinik Saraf RS DR. M. Djamil Padang belum pernah dilakukan. Tujuan penelitian ini adalah menentukan faktor-faktor yang mempengaruhi terjadinya insomnia di poliklinik saraf RS DR. M. Djamil Padang. Penelitian ini merupakan penelitian cross se...

  3. Performance Analysis of DRA Based OFDM Data Transmission With Respect to Novel High Speed RS Decoding

    Dr. S.V.A.V. Prasad; Anshu Thakur

    2015-01-01

    In this paper, we have analyzed the performance characteristics of OFDM data transmission with regard to a new high speed RS decoding algorithm. The various characteristics identified are mainly speed and accuracy of the transmission irrespective of channel behaviour. We consider two cases viz. data transmission without error control and data transmission with error control. Each of these cases are duly analyzed and it is proven that high speed RS decoding algorithms can actually ...

  4. A suite of RS/1 procedures for chemical laboratory statistical quality control and Shewhart control charting

    Shanahan, K.L.

    1990-09-01

    A suite of RS/1 procedures for Shewhart control charting in chemical laboratories is described. The suite uses the RS series product QCA (Quality Control Analysis) for chart construction and analysis. The suite prompts users for data in a user friendly fashion and adds the data to or creates the control charts. All activities are time stamped. Facilities for generating monthly or contiguous time segment summary charts are included. The suite is currently in use at Westinghouse Savannah River Company.

  5. Development of Cloud Detection Methods Using CFH, GTS1, and RS80 Radiosondes

    ZHANG Jinqiang; CHEN Hongbin; BIAN Jianchun; XUAN Yuejian; DUAN Yunjun; Maureen CRIBB

    2012-01-01

    The accuracies of three instruments in measuring atmospheric column humidity were assessed during an upper troposphere and lower stratosphere observation campaign conducted from 7 to 13 August 2009 in Kunming,China.The three instruments are a cryogenic frost-point hygrometer (CFH),a Vaisala RS80 radiosonde (RS80),and a GTS1 radiosonde (GTS1).The accuracy of relative humidity (RH) measurements made by the CFH,GTS1,and RS80 was similar between the surface and 500 hPa (~5.5 km above sea level).However,above 500 hPa,the errors in RH measurements made by the RS80,relative to measurements made by the CFH,are much less than those detected with the GTS1.Three different retrieval methods for determining cloud boundaries from CFH,RS80,and GTS1 measurements were developed and take into account the differences in accuracy among the three instruments.The method for the CFH is based on RH thresholds at all levels,which demands high accuracy.Given that the accuracy of RH measurements decreases at higher altitudes,the cloud detection methods for RS80 and GTS1 are different for different altitude ranges.Below 5 km,the methods for the RS80 and the GTS1 are similar to that of the CFH; above 5 km,the methods for the RS80 and the GTS1 are both developed based on the second-order derivatives of temperature and RH with respect to height,but with different criteria applied.Comparisons of cloud-layer retrievals derived from the three measurements are also made.

  6. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  7. Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.

    Schmidt, Rachel M; Carter, Micaela M; Chu, Michelle L; Latario, Casey J; Stadler, Sarah K; Stauff, Devin L

    2016-05-01

    Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive pathogens within the phylum Firmicutes overcome heme toxicity by sensing heme through HssRS, a two-component system that regulates the heme detoxification transporter HrtAB. Here we show that heme sensing by HssRS and heme detoxification by HrtAB occur in the insect pathogen Bacillus thuringiensis We find that in B. thuringiensis, HssRS directly regulates an operon, hrmXY, encoding hypothetical membrane proteins that are not found in other Firmicutes with characterized HssRS and HrtAB systems. This novel HssRS-regulated operon or its orthologs BMB171_c3178 and BMB171_c3330 are required for maximal heme resistance. Furthermore, the activity of HrmXY is not dependent on expression of HrtAB. These results suggest that B. thuringiensis senses heme through HssRS and induces expression of separate membrane-localized systems capable of overcoming different aspects of heme toxicity. PMID:27030728

  8. Lack of Association between Missense Variants in GRHL3 (rs2486668 and rs545809) and Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population

    He, Miao; Bian, Zhuan

    2016-01-01

    Background Grainyhead-like-3 (GRHL3) was recently identified as the second gene that, when mutated, can leads to Van der Woude syndrome, which is characterized by orofacial clefts (OFC) and lower lip pits. In addition, a missense variant (rs41268753) in GRHL3 confers risk for non-syndromic cleft palate cases of European ancestry. Together with interferon regulatory factor 6 (IRF6), GRHL3 may be associated with the risk of NSOFC which awaits for being verified across different ethnic populations. Objective The aim of this study was to investigate the possible relationship between common functional variants in GRHL3 and susceptibility to NSOFC, especially cleft palate cases, in a Han Chinese population, one of the ethnic groups with the highest birth prevalence of orofacial clefting. Methods Because the allele frequency for rs41268753 minor alleles was zero in our Chinese population, we selected functional single nucleotide polymorphisms (SNPs) spanning GRHL3 with minor allele frequencies (MAFs) > 5% in the Han Chinese population. Two SNPs which meet the above criteria were then genotyped in a case-control cohort comprising 1145 individuals using the TaqMan 5′-exonuclease allelic discrimination assay. Results SNPs rs2486668 and rs545809 were used in this study. Overall genotype and allele distributions of both SNPs in general and stratified genotyping analyses revealed no statistically significant differences between cases and controls. Further logistic regression analyses using different genetic models failed to reveal any evidence that these markers influence risk to NSOFC. Conclusions The variant rs41268753 in GRHL3 increases the risk for cleft palate in European population, but our findings failed to detect the link between two GRHL3 SNPs (rs2486668 and rs545809) and risk to NSOFC in the Han Chinese cohort. Although the present study did not provide any evidence that common functional variants in GRHL3 may contribute to NSOFC etiology in this Chinese population

  9. Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

    Wang M

    2016-07-01

    Full Text Available Meng Wang,1,* Zheng Wang,2,* Xi-Jing Wang,1 Tian-Bo Jin,3 Zhi-Ming Dai,4 Hua-Feng Kang,1 Hai-Tao Guan,1 Xiao-Bin Ma,1 Xing-Han Liu,1 Zhi-Jun Dai1 1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, 2Department of Medical Oncology, Xi’an Central Hospital, 3National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, 4Department of Anesthesia, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Background: In recent years, studies have demonstrated that polymorphisms in the promoters of Fas and FasL are significantly associated with breast cancer risk. However, the results of these studies were inconsistent. This case–control study was performed to explore the associations between Fas rs1800682 and FasL rs763110 polymorphisms and breast cancer. Materials and methods: A hospital-based case–control study of 560 Han Chinese females with breast cancer (583 controls was conducted. The MassARRAY system was used to search for a possible association between the disease risk and the two single nucleotide polymorphisms, Fas rs1800682 and FasL rs763110. Statistical analyses were performed using SNPStats software to conduct Pearson’s chi-square tests in five different genetic models. Odds ratios (ORs and 95% confidence intervals (CIs were calculated after adjustment to age and body mass index. PHASE v2.1 software was used to reconstruct all common haplotypes.Results: A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06–1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04–1.66, and also it was found that the FasL rs763110 polymorphism may decrease the risk. Stratified analyses demonstrated that the rs763110 polymorphism was associated with lower breast cancer risk among postmenopausal females

  10. Lack of association between KCNJ11 (rs5219 and ABCC8 (rs757110 polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

    Irina Arkadyevna Bondar

    2015-03-01

    Full Text Available AimSulfonylureas (SU are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM. There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region.Materials and Methods326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219 and ABCC8 (rs757110 was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia.ResultsPatients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8±9.1 years vs. 61.6±7.9 years, p<0.01, had later onset of type 2 diabetes (59.7±9.2 years vs. 48.3±9.3 years, p <0.01, shorter duration of type 2 diabetes (6.1±4.8 years vs. 13.2±7.3 years, p<0.01 and weak insulin resistance: fasting insulin 9.7±6.9 mU/ml vs. 13.6±12.7 mU/ml (p<0.05, HOMA-IR 3.1±2.2 vs. 6.2±6.0 (p<0.01, triglycerides 1.76±0.83 mmol/l vs. 2.42±1.97 mmol/l (p <0.01. Statistically significant differences between KCNJ11 (rs5219 and ABCC8 (rs757110 genotypes and response to SU-therapy was not found. The frequency of risk allele T polymorphism rs5219 KCNG11 gene in patients with a good response to SU was 0.38 and in the patients with a poor response to SU -0.38 (χ2=0.02, р=0.89. The frequency of the risk allele G polymorphism rs757110 ABCC8 gene in patients with a good response to SU was 0.40 and in the patients with poor response to SU -0.37 (χ2

  11. Association between CYP19 gene SNP rs2414096 Polymorphism and polycystic ovary syndrome in Chinese women

    Yi Long

    2009-12-01

    Full Text Available Abstract Background Several studies have reported the association of the SNP rs2414096 in the CYP19 gene with hyperandrogenism, which is one of the clinical manifestations of polycystic ovary syndrome (PCOS. These studies suggest that SNP rs2414096 may be involved in the etiopathogenisis of PCOS. To investigate whetherthe CYP19 gene SNP rs2414096 polymorphism is associated with the susceptibility to PCOS, we designed a case-controlled association study including 684 individuals. Methods A case-controlled association study including 684 individuals (386 PCOS patients and 298 controls was performed to assess the association of SNP rs2414096 with PCOS. Genotyping of SNP rs2414096 was conducted by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP method that was performed on genomic DNA isolated from blood leucocytes. Results were analyzed in respect to clinical test results. Results The genotypic distributions of rs2414096 (GG, AG, AA in the CYP19 gene (GG, AG, AA in women with PCOS (0.363, 0.474, 0.163, respectively were significantly different from that in controls (0.242, 0.500, 0.258, respectively (P = 0.001. E2/T was different between the AA and GG genotypes. Age at menarche (AAM and FSH were also significantly different among the GG, AG, and AA genotypes in women with PCOS (P = 0.0391 and 0.0118, respectively. No differences were observed in body mass index (BMI and other serum hormone concentrations among the three genotypes, either in the PCOS patients or controls. Conclusions Our data suggest that SNP rs2414096 in the CYP19 gene is associated with susceptibility to PCOS.

  12. Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

    Ou, Jingxing; Vijayasarathy, Camasamudram; Ziccardi, Lucia; Chen, Shan; Zeng, Yong; Marangoni, Dario; Pope, Jodie G; Bush, Ronald A; Wu, Zhijian; Li, Wei; Sieving, Paul A

    2015-07-01

    Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual signal transmission through the retina and progressive visual acuity loss, and mice lacking retinoschisin (RS1) recapitulate human disease. Here, we demonstrate that restoration of RS1 via retina-specific delivery of adeno-associated virus type 8-RS1 (AAV8-RS1) vector rescues molecular pathology at the photoreceptor-depolarizing bipolar cell (photoreceptor-DBC) synapse and restores function in adult Rs1-KO animals. Initial development of the photoreceptor-DBC synapse was normal in the Rs1-KO retina; however, the metabotropic glutamate receptor 6/transient receptor potential melastatin subfamily M member 1-signaling (mGluR6/TRPM1-signaling) cascade was not properly maintained. Specifically, the TRPM1 channel and G proteins Gαo, Gβ5, and RGS11 were progressively lost from postsynaptic DBC dendritic tips, whereas the mGluR6 receptor and RGS7 maintained proper synaptic position. This postsynaptic disruption differed from other murine night-blindness models with an electronegative electroretinogram response, which is also characteristic of murine and human XLRS disease. Upon AAV8-RS1 gene transfer to the retina of adult XLRS mice, TRPM1 and the signaling molecules returned to their proper dendritic tip location, and the DBC resting membrane potential was restored. These findings provide insight into the molecular plasticity of a critical synapse in the visual system and demonstrate potential therapeutic avenues for some diseases involving synaptic pathology. PMID:26098217

  13. Effect of IAA produced by Klebsiella oxytoca Rs-5 on cotton growth under salt stress.

    Liu, Yan; Shi, Zaiqiang; Yao, Lixia; Yue, Haitao; Li, Hui; Li, Chun

    2013-01-01

    Klebsiella oxytoca Rs-5 isolated with ACC (1-aminocyclopropane-1-carboxylate) deaminase activity as the sole nitrogen source could obviously promote cotton seedling growth under salt stress and produce phytohormone indole-3-acetic acid (IAA). The amount of IAA produced by the strain Rs-5 was measured, and the effect of IAA on cotton growth under salt stress was studied. Different treatments were set to treat cotton seeds with fermentation broth containing strain Rs-5 (FB), strain Rs-5, fermentation broth with bacteria removed (FB-NB), fermentation broth without bacteria or IAA (FB-NB-NI) and single IAA solutions (SI) according to the IAA concentration after strain Rs-5 culturing of 48, 72 and 120 h. The germination rate, dry weight, plant height, root length and malondialdehyde (MDA), proline and endogenous IAA content in roots were determined. The results showed that both IAA produced by strain Rs-5 and the strain were effective in promoting cotton growth under salt stress. The growth and ability to resist salt stress of cotton seedlings were increased with the enhancement of IAA concentration. The treatment of FB containing bacteria and IAA at 120 h obtained the best state of cotton growth, when the IAA content was the highest in the fermentation broth (42.14 μg·L(-1)). The germination rate, dry weight, plant height and root length were increased by 29.4%, 24.3%, 27.2% and 27.2% , respectively, compared to the saline control. The strain Rs-5 and/or IAA could obviously reduce the MDA and proline content and increase the endogenous IAA content in cotton seedlings. However, the efficacy of other components in the fermentation broth was inconspicuous. PMID:23518519

  14. Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.

    Jahan, Parveen; Ramachander, V R Vinish; Maruthi, G; Nalini, S; Latha, K Prasanna; Murthy, T S R

    2014-04-01

    Breast cancer is the most common female neoplasm that drives the transformation of normal mammary epithelial cells into highly malignant derivatives. Forkhead Box Protein3 (Foxp3), a tumor suppressor/immunomodulatory gene, which controls the function of Treg cells and oncogenes is down regulated in breast cancer. The main aim of the present study is to evaluate the potential influence of Foxp3-3279 C>A polymorphism (rs3761548) and -2383 C>T polymorphism (rs3761549) in 202 breast cancer patients and 130 normal healthy women of Indian origin. The genotypes were determined using ARMS-PCR for rs3761548 and PCR-RFLP method for rs3761549 using specific primers. The results revealed lack of association of these two polymorphisms with breast cancer susceptibility. However, with respect to AA genotype of rs3761548, we found highly significant association with the advanced stage (T3-4) of the tumor (OR = 3.90; 95% confidence interval (CI) = 1.56-9.70; p = 0.03). Stratified data also revealed an association of homozygous mutant genotype with advanced stage of tumor in premenopausal women (OR = 4.56; 95% CI = 1.07-19.38; p = 0.04) with disease duration of <6 months (OR =  .10; 95% CI = 1.80-20.50; p = 0.002) suggestive of modulating effect of rs3761548 in tumor progression. We conclude that Foxp3 rs37161548 has a potential to be a polymorphic marker for tumor progression in premenopausal breast cancer patients in Indian women. PMID:24338714

  15. Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population

    Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studies (GWAS) have been the ideal strategy to identify new common, low-penetrance susceptibility loci. In this case–control study, we try to validate in our population nine melanoma associated markers selected from published GWAS in melanoma predisposition. We genotyped the 9 markers corresponding to 8 genes (PARP1, MX2, ATM, CCND1, NADSYN1, CASP8, IRF4 and CYP2R1) in 566 cases and 347 controls from a Spanish population using KASPar probes. Genotypes were analyzed by logistic regression and adjusted by phenotypic characteristics. We confirm the protective role in MM of the rs3219090 located on the PARP1 gene (p-value 0.027). Additionally, this SNP was also associated with eye color (p-value 0.002). A second polymorphism, rs12203592, located on the IRF4 gene was associated with protection to develop MM for the dominant model (p-value 0.037). We have also observed an association of this SNP with both lentigines (p-value 0.014) and light eye color (p-value 3.76 × 10-4). Furthermore, we detected a novel association with rs1485993, located on the CCND1 gene, and dark eye color (p-value 4.96 × 10-4). Finally, rs1801516, located on the ATM gene, showed a trend towards a protective role in MM similar to the one firstly described in a GWAS study. To our knowledge, this is the first time that these SNPs have been associated with MM in a Spanish population. We confirmed the proposed role of rs3219090, located on the PARP1 gene, and rs12203592, located on the IRF4 gene, as protective to MM along the same lines as have previous genome-wide associated works. Finally, we have seen associations between IRF4, PARP1, and CCND1 and phenotypic characteristics, confirming previous results for the IRF4 gene and presenting novel data for the last two, suggesting that pigmentation

  16. DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data.

    Zhang, Yuanwei; Zang, Qiguang; Zhang, Huan; Ban, Rongjun; Yang, Yifan; Iqbal, Furhan; Li, Ao; Shi, Qinghua

    2016-07-01

    Small RNA (sRNA) Sequencing technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent variations from their canonical sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). However, integrated tool to precisely detect and systematically annotate isomiRs from sRNA sequencing data is still in great demand. Here, we present an online tool, DeAnnIso (Detection and Annotation of IsomiRs from sRNA sequencing data). DeAnnIso can detect all the isomiRs in an uploaded sample, and can extract the differentially expressing isomiRs from paired or multiple samples. Once the isomiRs detection is accomplished, detailed annotation information, including isomiRs expression, isomiRs classification, SNPs in miRNAs and tissue specific isomiR expression are provided to users. Furthermore, DeAnnIso provides a comprehensive module of target analysis and enrichment analysis for the selected isomiRs. Taken together, DeAnnIso is convenient for users to screen for isomiRs of their interest and useful for further functional studies. The server is implemented in PHP + Perl + R and available to all users for free at: http://mcg.ustc.edu.cn/bsc/deanniso/ and http://mcg2.ustc.edu.cn/bsc/deanniso/. PMID:27179030

  17. RS-34 Phoenix In-Space Propulsion System Applied to Active Debris Removal Mission

    Esther, Elizabeth A.; Burnside, Christopher G.

    2014-01-01

    In-space propulsion is a high percentage of the cost when considering Active Debris Removal mission. For this reason it is desired to research if existing designs with slight modification would meet mission requirements to aid in reducing cost of the overall mission. Such a system capable of rendezvous, close proximity operations, and de-orbit of Envisat class resident space objects has been identified in the existing RS-34 Phoenix. RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper program; specifically the pressure-fed storable bi-propellant Stage IV Post Boost Propulsion System. The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC has obtained permission from the USAF to obtain all the remaining RS-34 stages for re-use opportunities. The MSFC Advanced Concepts Office (ACO) was commissioned to lead a study for evaluation of the Rocketdyne produced RS-34 propulsion system as it applies to an active debris removal design reference mission for resident space object targets including Envisat. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy payloads at multiple orbital locations. The RS-34 Concept Study lead by sought to further understand application for a similar orbital debris design reference mission to provide propulsive capability for rendezvous, close proximity operations to support the capture phase of the mission, and deorbit of single or multiple large class resident space objects. Multiple configurations varying the degree of modification were identified to trade for dry mass optimization and

  18. FIRE, A Test Bed for ARIES-RS/AT Advanced Physics and Plasma Technology

    The overall vision for FIRE [Fusion Ignition Research Experiment] is to develop and test the fusion plasma physics and plasma technologies needed to realize capabilities of the ARIES-RS/AT power plant designs. The mission of FIRE is to attain, explore, understand and optimize a fusion dominated plasma which would be satisfied by producing D-T [deuterium-tritium] fusion plasmas with nominal fusion gains ∼10, self-driven currents of ∼80%, fusion power ∼150-300 MW, and pulse lengths up to 40 s. Achieving these goals will require the deployment of several key fusion technologies under conditions approaching those of ARIES-RS/AT. The FIRE plasma configuration with strong plasma shaping, a double null pumped divertor and all metal plasma-facing components is a 40% scale model of the ARIES-RS/AT plasma configuration. ''Steady-state'' advanced tokamak modes in FIRE with high beta, high bootstrap fraction, and 100% noninductive current drive are suitable for testing the physics of the ARIES-RS/A T operating modes. The development of techniques to handle power plant relevant exhaust power while maintaining low tritium inventory is a major objective for a burning plasma experiment. The FIRE high-confinement modes and AT-modes result in fusion power densities from 3-10 MWm-3 and neutron wall loading from 2-4 MWm-2 which are at the levels expected from the ARIES-RS/AT design studies

  19. Prediction of solubilities for ginger bioactive compounds in hot water by the COSMO-RS method

    The solubilities in water of four main ginger bioactives, 6-gingerol, 6-shogaol, 8-gingerol and 10-gingerol, were predicted using a conductor-like screening model for real solvent (COSMO-RS) calculations. This study was conducted since no experimental data are available for ginger bioactive solubilities in hot water. The σ-profiles of these selected molecules were calculated using Gaussian software and the solubilities were calculated using the COSMO-RS method. The solubilities of these ginger bioactives were calculated at 50 to 200 °C. In order to validate the accuracy of the COSMO-RS method, the solubilities of five hydrocarbon molecules were calculated using the COSMO-RS method and compared with the experimental data in the literature. The selected hydrocarbon molecules were 3-pentanone, 1-hexanol, benzene, 3-methylphenol and 2-hydroxy-5-methylbenzaldehyde. The calculated results of the hydrocarbon molecules are in good agreement with the data in the literature. These results confirm that the solubilities of ginger bioactives can be predicted using the COSMO-RS method. The solubilities of the ginger bioactives are lower than 0.0001 at temperatures lower than 130 °C. At 130 to 200 °C, the solubilities increase dramatically with the highest being 6-shogaol, which is 0.00037 mole fraction, and the lowest is 10-gingerol, which is 0.000039 mole fraction at 200 °C.

  20. Comments on: Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran

    Michael H. Preuß

    2016-02-01

    Full Text Available Foroughmand et al. (1 have recently reported association between coronary artery disease (CAD and two well-known single nucleotide polymorphisms (SNPs on chromosome 9p21.3 in subjects from South-West Iran. We doubt the validity of their findings. Genotyping was done using ARMS-PCR for rs1333049 and rs10757274 in their study. When we first looked at the genotype frequencies, we observed a substantial excess of heterozygote subjects for both SNPs. Specifically, the relative excess of heterozygosity (REH (2, a measure for the strength of deviation from Hardy-Weinberg equilibrium (HWE, was approximately 137% for rs1333049 in controls (REH=2.3688, Table 1. In contrast, we did not observe any deviation from HWE in our own studies (3, 4. We additionally conducted a short literature search to identify other studies from Asia, which reported genotype frequencies in controls for rs1333049. These studies are summarized in table 1. None of these studies shows a deviation from HWE in their control groups (all P>0.05. In summary, only the recent study by Foroughmand and colleagues (1 shows a marked deviation from HWE in controls with this deviation observed for both reported SNPs. Possible reasons for deviations from HWE have been summarized, e.g., in Ziegler et al. (2. The most likely cause for such a strong deviation from HWE is genotyping errors, especially because genotyping by ARMS-PCR plus gel electrophoresis is prone to such errors. However, REH could also be caused by population specifics, which has been discussed by Namipashaki et al. (5. In any case, we (2 and others (5 recommend the investigation of HWE in population-based genetic association studies to improve quality and reliability of the research results.

  1. Promoter SNPs rs116896264 and rs73933062 form a distinct haplotype and are associated with galectin-4 overexpression in colorectal cancer.

    Helwa, Reham; Ramadan, Mohamed; Abdel-Wahab, Abdel-Hady A; Knappskog, Stian; Bauer, Andrea S

    2016-07-01

    Galectin-4 is a member of the galectin family which consists of 15 galactoside-binding proteins. Previously, galectin-4 has been shown to have a role in cancer progression and metastasis and it is found upregulated in many solid tumours, including colorectal cancer (CRC). Recently, the role in the metastatic process was suggested to be via promoting cancer cells to adhere to blood vascular endothelium. In the present study, the regulatory region of LGALS4 (galectin-4) in seven colon cell lines was investigated with respect to genetic variation that could be linked to expression levels and therefore a tumourigenic effect. Interestingly, qRT-PCR and sequencing results revealed that galectin-4 upregulation is associated with SNPs rs116896264 and rs73933062. By use of luciferase reporter- and pull-down assays, we confirmed the association between the gene upregulation and the two SNPs. Also, using pull-down assay followed by mass spectrometry, we found that the presence rs116896264 and rs73933062 is changing transcription factors binding sites. In order to assess the frequencies of the two SNPs among colon cancer patients and healthy individuals, we genotyped 75 colon cancer patients, 12 patients with adenomatous polyposis and 17 patients with ulcerative colitis and we performed data mining in the 1000 genomes databank. We found the two SNPs co-occuring in 21% of 75 CRC patients, 0 out of 12 patients of adenomatous polyposis, and 6 out of 17 patients (35%) with ulcerative colitis. Both in the patient samples and in the 1000 genomes project, the two SNPs were found to co-occur whenever present (D' = 1). PMID:26681582

  2. Demanda hídrica e coeficientes de cultura (Kc para macieiras em Vacaria, RS Water requirement and crop coefficients (Kc for apple trees in Vacaria, RS, Brazil

    Marco Antônio Fonseca Conceição

    2011-03-01

    Full Text Available O objetivo do presente trabalho foi determinar a demanda hídrica e os coeficientes de cultura (Kc para macieiras cultivadas na região de Vacaria, RS. O trabalho foi desenvolvido na Estação Experimental de Fruticultura Temperada (EEFT da Embrapa Uva e Vinho, localizada em Vacaria, RS, em plantas da cultivar 'Royal Gala' (Malus domestica sobre porta-enxerto M9. Foram determinados os valores do potencial matricial da água no solo, empregando-se tensiômetros de punção. Com base nesses valores, determinou-se a umidade volumétrica e o balanço hídrico mensal. O consumo hídrico da cultura variou entre 0,3mm dia-1 a 4,5mm dia-1, com média de 1,9mm dia-1. O coeficiente da cultura (Kc apresentou tendência quadrática, variando entre 0,19 e 0,88, com média igual a 0,58.The objective of this study was to determine the water requirement and the crop coefficients (Kc values for apple trees cultivated in Vacaria, RS. The study was conducted at the Experimental Station of Temperate Fruits (EEFT of Embrapa Grape and Wine, located in Vacaria, RS, in plants of the cultivar 'Royal Gala' (Malus domestica on the rootstock M9. The soil water matric potential values, that were determined employing tensiometers, were used to obtain the soil moisture and the monthly soil water balance. The water consumption of the culture ranged from 0.3mm day-1 to 4.5mm day-1, with an average of 1.9mm day-1. The crop coefficient (Kc presented a quadratic trend, ranging between 0.19 and 0.88, with mean value of 0.58.

  3. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis

    Chen, Tao

    2015-07-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  4. Genetic Algorithm to Make Persistent Security and Quality of Image in Steganography from RS Analysis

    Nair, T R Gopalakrishnan; S, Manas

    2012-01-01

    Retention of secrecy is one of the significant features during communication activity. Steganography is one of the popular methods to achieve secret communication between sender and receiver by hiding message in any form of cover media such as an audio, video, text, images etc. Least significant bit encoding is the simplest encoding method used by many steganography programs to hide secret message in 24bit, 8bit colour images and grayscale images. Steganalysis is a method of detecting secret message hidden in a cover media using steganography. RS steganalysis is one of the most reliable steganalysis which performs statistical analysis of the pixels to successfully detect the hidden message in an image. However, existing steganography method protects the information against RS steganalysis in grey scale images. This paper presents a steganography method using genetic algorithm to protect against the RS attack in colour images. Stego image is divided into number of blocks. Subsequently, with the implementation ...

  5. Lack of association between the prothrombin rs1799963 polymorphism and juvenile myoclonic epilepsy

    João Paulo Lopes Born

    2015-04-01

    Full Text Available Juvenile myoclonic epilepsy (JME accounts for 26% of generalized idiopathic epileptic syndromes. The highest levels of thrombin activity are closely involved in the development of neurological diseases, including epilepsy. The prothrombin c.20210G>A (rs1799963 variation, which alters prothrombin mRNA stability, is associated with high plasma prothrombin levels. Objective : The present study was designed to investigate whether the SNP rs1799963 is a risk factor for JME in the northeastern Brazilian population. Results : The polymorphism was genotyped in 207 controls and 123 patients using polymerase chain reaction-restriction fragment length polymorphism method. No significant differences were observed in the genotype and allele frequencies of this polymorphism between cases and controls. Conclusion : These results present no evidence for an association of rs1799963 with JME. Further studies including other types of epilepsy are required to investigate the involvement of prothrombin gene in the genetic susceptibility to chronic seizure.

  6. P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks

    Mingchuan Zhang

    2014-01-01

    Full Text Available Routing in wireless sensor networks (WSNs is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH. Based on this model, we present a novel Physarum-based routing scheme (P-bRS for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms.

  7. P-bRS: a physarum-based routing scheme for wireless sensor networks.

    Zhang, Mingchuan; Wei, Wangyang; Zheng, Ruijuan; Wu, Qingtao

    2014-01-01

    Routing in wireless sensor networks (WSNs) is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH). Based on this model, we present a novel Physarum-based routing scheme (P-bRS) for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms. PMID:24672326

  8. Application of COSMO-RS as an excipient ranking tool in early formulation development.

    Pozarska, Agnieszka; da Costa Mathews, Claudia; Wong, Mei; Pencheva, Klimentina

    2013-07-16

    The low amounts of drug available in early discovery often results in limited information on the physico-chemical (solubility etc.) properties of a compound being obtained. As a result, predictive tools and miniaturised screens have been investigated to aid formulation development in early discovery. This study looks at the potential application of the quantum chemistry program, Conductor Screening Model for Real Solvents (COSMO-RS) to help with the selection of excipients for formulation development in early discovery. The excipient solubility predictions obtained from COSMO-RS were compared to experimentally obtained solubilities. The results showed that in general, COSMO-RS was able to help formulators with the selection of the most appropriate excipients to solubilise the model compound. PMID:23639717

  9. Psychometric Properties of the Parent and Teacher ADHD Rating Scale (ADHD-RS)

    Makransky, Guido; Bilenberg, Niels

    2014-01-01

    Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood and adolescence. Rating the severity of psychopathology and symptom load is essential in daily clinical practice and in research. The parent and teacher ADHD-Rating Scale (ADHD-RS) includes...... inattention and hyperactivity/impulsivity subscales and is one of the most frequently used scales in treatment evaluation of children with ADHD. An extended version, mADHD-RS, also includes an oppositional defiant disorder subscale. The partial credit Rasch model, which is based on item response theory, was...... used to test the psychometric properties of this scale in a sample of 566 Danish school children between 6 and 16 years of age. The results indicated that parents and teachers had different frames of reference when rating symptoms in the mADHD-RS. There was support for the unidimensionality of the...

  10. Lidt om DØRS' selvforståelse: om lønrelationerne i SMEC

    Harck, Søren H.

    1997-01-01

    According to the interpretation of the Danish macroeconomic model SMEC that is being offered by its originator (The Secretariate of The Economic Council (DØRS)) the model entails a vertical long-run supply curve. Closer scrutiny, however, reveals this conception to be devoid of any foundation at ...... does in fact entail a horizontal Phillips curve, the level of which is determined by the exchange rate adjusted foreign inflation rate. Evidently, the policy implications of getting the interpretation right are, potentially, huge....... all: if the wage-to-price elasticity is taken to be equal to one (as stipulated by DØRS), the model turns out to imply, even in the long run, an old-fashioned, stable Phillips curve; and if, more realistically, this elasticity is taken to be smaller than one, the error-correction specification by DØRS...

  11. Working in partnership to advance the 3Rs in toxicity testing

    Toxicological assessment of pharmaceutical and non-pharmaceutical chemicals is a regulatory requirement to ensure all compounds likely to be exposed to humans or the environment are safe. These studies rely on the use of large numbers of animals and involve a number of assumptions and extrapolations that remain controversial in assuring consumer safety. The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has taken a collaborative approach to identify opportunities for implementation of the 3Rs principles (Replacement, Reduction and Refinement) to drive innovation and support animal welfare in toxicity testing. This review highlights the mechanisms by which the NC3Rs is working with the pharmaceutical and chemical industries and regulatory authorities to achieve these goals.

  12. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Rômulo Bertuzzi

    Full Text Available The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150 physically active young men performed the following tests: a a maximal incremental treadmill test, b two constant-speed running tests (10 km · h(-1 and 12 km · h(-1 to determine the running economy, and c a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1 (p = 0.232 and 12 km · h(-1 (p = 0.259. Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337. These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

  13. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Bertuzzi, Rômulo; Pasqua, Leonardo A; Bueno, Salomão; Lima-Silva, Adriano Eduardo; Matsuda, Monique; Marquezini, Monica; Saldiva, Paulo H

    2014-01-01

    The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km · h(-1)) and 12 km · h(-1)) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1) (p = 0.232) and 12 km · h(-1) (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running. PMID:25188268

  14. SHBG gene polymorphism (rs1799941 associates with metabolic syndrome in children and adolescents.

    Marquitta J White

    Full Text Available Metabolic syndrome (MetS is a complex disorder characterized by coexistence of several cardiometabolic (CM factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD. The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.Genetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs, previously shown to modulate lipid or sex hormone binding globulin (SHBG levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls.Logistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006. The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012, while in cases there was no association between rs1799941 and SHBG levels (p = 0.963.The significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.

  15. Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?

    Bertuzzi, Rômulo; Pasqua, Leonardo A.; Bueno, Salomão; Lima-Silva, Adriano Eduardo; Matsuda, Monique; Marquezini, Monica; Saldiva, Paulo H.

    2014-01-01

    The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km•h−1 and 12 km•h−1) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km•h−1 (p = 0.232) and 12 km•h−1 (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running. PMID:25188268

  16. Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280

    Fan He; Yi Zheng; Huan-Huan Huang; Yu-Hang Cheng; Chuan-Yue Wang

    2015-01-01

    Background:Tourette syndrome (TS) is a complex,heterozygous genetic disorder.The number of molecular genetic studies have investigated several candidate genes,particularly those implicated in the dopamine system.The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.There was not any report about the association study of TS and DRD3 gene in Han Chinese population.We combined a case-control genetic association analysis and nuclear pedigrees transmission disequilibrium test (TDT) analysis to investigate the association between DRD3 gene rs6280 single nucleotide polymorphisms (SNPs) and TS in a Han Chinese population.Methods:A total of 160 TS patients was diagnosed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition.The DRD3 gene rs6280 SNPs were genotyped by TaqMan SNP genotyping assay technique in all subjects.We used a case-control genetic association analysis to compare the difference in genotype and allele frequencies between 160 TS patients and 90 healthy controls.At the same time,we used TDT analysis to identify the DRD3 gene rs6280 transmission disequilibrium among 10l nuclear pedigrees.Results:The genotype and allele frequency of DRD3 gene rs6280 SNPs had no statistical difference between control group (90) and TS group (160) (x2 =3.647,P =0.161; x2 =0.643,P =0.423) using Chi-squared test.At the basis of the 101 nuclear pedigrees,TDT analysis showed no transmission disequilibrium ofDRD3 gene rs6280 SNPs (x2 =0; P =1).Conclusions:Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.

  17. Nitrofurantoin, phenazopyridine, and the superoxide-response regulon soxRS of Escherichia coli.

    Amábile-Cuevas, Carlos F; Arredondo-García, José Luis

    2013-12-01

    Nitrofurantoin and phenazopyridine are two drugs commonly used against urinary tract infections. Both compounds exert oxidative damage in patients deficient in glucose-6-phosphate dehydrogenase. This study was done to assess the interactions of these drugs with the soxRS regulon of Escherichia coli, a superoxide-defense system (that includes a nitroreductase that yields the active metabolite of nitrofurantoin) involved in antibiotic multi-resistance. The effects of either nitrofurantoin or phenazopyridine, upon strains with different soxRS genotypes, were measured as minimum inhibitory concentrations (MICs) and growth curves. Also, the ability of these drugs to induce the expression of a soxS'::lacZ gene fusion was assessed. The effect of antibiotics in the presence of phenazopyridine, paraquat (a known soxRS inducer), or an efflux inhibitor, was measured using the disk diffusion method. A strain constitutively expressing the soxRS regulon was slightly more susceptible to nitrofurantoin, and more resistant to phenazopyridine, compared to wild-type and soxRS-deleted strains, during early treatment, but 24-h MICs were the same (8 mg/l nitrofurantoin, 1,000 mg/l phenazopyridine) for all strains. Both compounds were capable of inducing the expression of a soxS'::lacZ fusion, but less than paraquat. Subinhibitory concentrations of phenazopyridine increased the antimicrobial effect of ampicillin, chloramphenicol, tetracycline, and nitrofurantoin. The induction or constitutive expression of the soxRS regulon seems to be a disadvantage for E. coli during nitrofurantoin exposure; but might be an advantage during phenazopyridine exposure, indicating that the latter compound could act as a selective pressure for mutations related to virulence and antibiotic multi-resistance. PMID:23793794

  18. Propagation of ELF Radiation from RS-LC System and Red Sprites in Earth-Ionosphere Waveguide

    Manoj Kumar Paras

    2012-08-01

    Full Text Available In this paper, two different mechanisms return stroke-lateral corona (RS-LC system and red sprites which excite Earth-ionosphere waveguide have been discussed. The electric and magnetic fields from RS-LC system and red spites in the Earth-ionosphere waveguide have been calculated. It has been found that red sprites contribute to the Schumann resonances (SR greatly as compared to the RS-LC system.

  19. Implementation of RS-485 Communication between PLC and PC of Distributed Control System Based on VB

    Lian Zhang, Chuan; Da Huang, Zhi; Qing Zhou, Gui; Chong, Kil To

    2015-05-01

    This paper focuses on achieving RS-485 communication between programmable logical controller (PLC) and PC based on visual basic 6.0 (VB6.0) on an experimental automatic production line. Mitsubishi FX2N PLCs and a PC are chosen as slave stations and main station, respectively. Monitoring software is developed using VB6.0 for data input/output, flow control and online parameters setting. As a result, all functions are fulfilled with robust performance. It is concluded from results that one PC can monitor several PLCs using RS-485 communication.

  20. SNP rs1511412 in FOXL2 gene as a risk factor for keloid by meta analysis

    Lu, Wensheng; Zheng, Xiaodong; Liu, Shengli; Ding, Maoqian; Xie, Jian; Yao, Xiuhua; Zhang, Lanfang; Hu, Bai

    2015-01-01

    Objective: Determine whether SNP rs1511412 is associated with keloid. Design and methods: One large-scale GWAS identified association between SNP rs1511412 in the FOXL2 gene and keloid disease in the Japanese population. However, researchers didn’t observe significant association for keloid in Chinese Han population (PBonferroni>0.05). It’s probable that the frequency of this variant in Chinese Han population was relatively low and the sample size was not very large in this study (power =45.5...

  1. Association Between hTERT rs2736100 Polymorphism and Sensitivity to Anti-cancer Agents

    Julie eKim

    2013-08-01

    Full Text Available Background: The rs2736100 single nucleotide polymorphism (SNP is located in the intron 2 of human telomerase reverse transcriptase (hTERT gene. Recent genome-wide association studies (GWAS have consistently supported the strong association between this SNP and risk for multiple cancers. Given the important role of the hTERT gene and this SNP in cancer biology, we hypothesize that rs2736100 may also confer susceptibility to anti-cancer drug sensitivity. In this study we aim to investigate the correlation between the rs2736100 genotype and the responsiveness to anti-cancer agents in the NCI-60 cancer cell panel. Methods and Materials: The hTERT rs2736100 was genotyped in the NCI-60 cancer cell lines. The relative telomere length of each cell line was quantified using real-time PCR. The genotype was then correlated with publically available drug sensitivity data of two agents with telomerase-inhibition activity: Geldanamycin (HSP90 inhibitor and RHPS4/BRACO19 (G-quadruplex stabilizer as well as additional 110 commonly used agents with established mechanism of action. The association between rs2736100 and mutation status of TP53 gene was also tested.Results: The C allele of the SNP was significantly correlated with increased sensitivity to RHPS4/BRACO19 with an additive effect (r=-0.35, p=0.009 but not with Geldanamycin. The same allele was also significantly associated with sensitivity to antimitotic agents compared to other agents (p=0.003. The highest correlation was observed between the SNP and paclitaxel (r=-0.36, p=0.005. The telomere length was neither associated with rs2736100 nor with sensitivity to anti-cancer agents. The C allele of rs2736100 was significantly associated with increased mutation rate in TP53 gene (p=0.004.Conclusion: Our data suggested that the cancer risk allele of hTERT rs2736100 polymorphism may also affect the cancer cell response to both TERT inhibitor and anti-mitotic agents, which might be attributed to the elevated

  2. Signal Transduction through CsrRS Confers an Invasive Phenotype in Group A Streptococcus

    Tran-Winkler, Hien J.; Love, John F.; Gryllos, Ioannis; Wessels, Michael R.

    2011-01-01

    The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A Streptococcus (GAS). While some studies have suggested that the sensor histidine kinase CsrS responds to membrane perturbations as a result of various environmental stresses, other data have implicated the human antimicrobial peptide LL-37 and extracellular Mg2+ as specific signals. We now report that Mg2+ and LL-37 have opposite effects on expression of multiple genes that are activated or rep...

  3. Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis

    Wei, Wen-Jun; Wang, Yu-Long; Li, Duan-Shu; Wang, Yu; Wang, Xiao-Feng; Zhu, Yong-Xue; Yang, Ya-Jun; Wang, Zhuo-Ying; Ma, Yan-yun; Yi WU; Jin, Li; Ji, Qing-Hai; Wang, Jiu-Cun

    2013-01-01

    Background Rs2910164, a Single nucleotide polymorphism (SNP) located in the precursor microRNA sequence of miR-146a, is the only MicroRNA sequence SNP studied in papillary thyroid cancer (PTC). Association studies had been performed in US and UK-Northern European populations, but results were inconsistence. This study evaluated the association between rs2910164 and the risk of PTC as well as benign thyroid tumor (BN), and examined the clinicopathological characteristics of PTC and BN for diff...

  4. Developing RESTful services with JAX-RS 2.0, WebSockets, and JSON

    Kalali, Masoud

    2013-01-01

    Written as an easy and practical guide, this book is a crash course on using JAX-RS 2.0, JSON, and WebSockets to develop RESTful services.Getting Started with Developing RESTful Web Services using JAX-RS 2.0, JSON, and WebSockets is a perfect reading source for application developers who are familiar with Java EE and are keen to understand the new HTML5-related functionality introduced in Java EE 7 to improve productivity. To take full advantage of this book, you need to be familiar with Java EE and have some basic understanding of using the GlassFish application server.

  5. An Integrated GIS/RS Approach for Soil Erosion Assessment and Modeling in Syrian Coastal Soils

    2001-01-01

    An integrated remote sensing (RS) and geographic information system (GIS) technique was employed to characterize the spatial distribution of the risk of soil erosion by water on Latakia district,Syria.The universal soil loss equation (USLE) was used to calculate the annual soil loss rates for Latakia soils.Mainly,remote sensing data,soil survey,land use inventory,elevation data and climatic atlases are used as resource data sets to generate USLE factor values.The results revealed that integration of GIS/RS with USLE was a practical and effective approach for monitoring soil erosion over large areas.

  6. Signal Transduction through CsrRS Confers an Invasive Phenotype in Group A Streptococcus

    Tran-Winkler, Hien J.; Love, John F.; Ioannis Gryllos; Wessels, Michael R.

    2011-01-01

    The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A Streptococcus (GAS). While some studies have suggested that the sensor histidine kinase CsrS responds to membrane perturbations as a result of various environmental stresses, other data have implicated the human antimicrobial peptide LL-37 and extracellular Mg(2+) as specific signals. We now report that Mg(2+) and LL-37 have opposite effects on expression of multiple genes that are activated or...

  7. A Study of the Börs Restaurant Experience and Forum Ravintolamaailma Bracelets Marketing

    Jalvas, Juuso

    2011-01-01

    The bracelet of Börs Restaurant Experience and Forum Ravintolamaailma has not made the impact among customers that it could have. The customers have not been aware of the benefits it offers and there have been problems with the promotion. The bracelet is being held as more of an entrance ticket and the goal for it is different. It should be viewed as something that brings more customers to Börs and the whole restaurant experience, something that has value. It was clear that the problem wa...

  8. Adaptive efficient video transmission over the Internet based on congestion control and RS coding

    黄伟红; 张福炎; 孙正兴

    2002-01-01

    An approach based on adaptive congestion control and adaptive error recovery with RS (Reed-Solomon) coding method is presented for efficient video transmission over the Internet.Featured by weighted moving average rate control and TCP-fdendliness,AVSP,a novel adaptive video streaming protocol,is designed with adjustable rate control parameters so as to respond quickly to the QoS status fluctuation during video transmission over the Internet.Combined with congestion control policy,an adaptive RS coding error recovery scheme with variable parameters is presented to enhance the robustness of MPEG video transmission over the Intemet with restriction to the total system bandwidth.``

  9. OpenRS-Cloud:A remote sensing image processing platform based on cloud computing environment

    2010-01-01

    This paper explores the use of cloud computing for remote sensing image processing.The main contribution of our work is to develop a remote sensing image processing platform based on cloud computing technology(OpenRS-Cloud).This paper focuses on enabling methodical investigations into the development pattern,computational model,data management and service model exploring this novel distributed computing model.The experimental INSAR processing flow is implemented to verify the efficiency and feasibility of OpenRS-Cloud platform.The results show that cloud computing is well suited for computationally-intensive and data-intensive remote sensing services.

  10. Kinetic and reactor modelling of lipases catalyzed (R,S)-1-phenylethanol resolution

    Chua Lee-Suana; Cheng Kian-Kaib; Lee Chew-Tinb; Mohamad-Roji Sarmidic; Ramlan Abdul-Azizc; Tang Boon-Sengd

    2010-01-01

    This study was focused on the development of a kinetic model and a reactor model for the enzymatic resolution of (R,S)-1-phenylethanol. The reaction progress curves catalyzed by immobilized lipases, ChiroCLEC-PC in batch stirred tank reactor were used to develop the kinetic model. The resolution followed Ping-Pong Bi-Bi mechanism with the inhibition of lauric acid, (R,S)-1-phenylethanol and water. The validity of the model was verified by fitting it to another experimental data catalyzed by i...

  11. Single-nucleotide polymorphism rs7251246 in ITPKC is associated with susceptibility and coronary artery lesions in Kawasaki disease.

    Ho-Chang Kuo

    Full Text Available Kawasaki disease (KD is a multi-systemic vasculitis that preferentially affects children. A single nucleotide polymorphism (SNP in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC has been identified to be an important polymorphism in the risk of KD. This study was conducted to comprehensively investigate the associations between all tagging SNPs of ITPKC in the risk of KD in a Taiwanese population. A total of 950 subjects (381 KD patients and 569 controls were recruited. Seven tagging SNPs (rs11673492, rs7257602, rs7251246, rs890934, rs10420685, rs2607420, rs2290692 were selected for TaqMan allelic discrimination assay. Clinical data of coronary artery lesions (CAL and aneurysms were collected for analysis. A significant association was found between rs7251246 in ITPKC and CAL formation. Haplotype analysis for ITPKC polymorphisms also confirmed this association in the patients with CAL and aneurysm formation. This is the first study to identify that SNP rs7251246 in ITPKC is associated with the severity of KD.

  12. PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population

    Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

    2012-01-01

    Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64–5.53; P = 4×10−4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226

  13. Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation

    Gao, Jie; Ding, Xuan-Sheng; Zhang, Yu-mao; Dai, De-zai; Liu, Mei; Zhang, Can; Dai, Yin

    2013-01-01

    Aim: Hypoxia/oxidative stress can alter the pharmacokinetics (PK) of CPU86017-RS, a novel antiarrhythmic agent. The aim of this study was to investigate the mechanisms underlying the alteration of PK of CPU86017-RS by hypoxia/oxidative stress. Methods: Male SD rats exposed to normal or intermittent hypoxia (10% O2) were administered CPU86017-RS (20, 40 or 80 mg/kg, ig) for 8 consecutive days. The PK parameters of CPU86017-RS were examined on d 8. In a separate set of experiments, female SD ra...

  14. Association of rs2072183 SNP and serum lipid levels in the Mulao and Han populations

    Miao Lin

    2012-05-01

    Full Text Available Abstract Background Niemann-pick C1-like 1 (NPC1L1 is a key protein for intestinal cholesterol transportation. Common single nucleotide polymorphisms (SNPs in the NPC1L1 gene have been associated with cholesterol absorption and serum lipid levels. The present study was undertaken to explore the possible association of NPC1L1 rs2072183 1735 C > G SNP and several environmental factors with serum lipid levels in the Mulao and Han populations. Methods Genotyping of the rs2072183 SNP was performed in 688 subjects of Mulao and 738 participants of Han Chinese. The interactions between NPC1L1 1735 C > G polymorphism and several environmental factors on serum lipid phenotypes were tested using the factorial design covariance analysis after controlling for potential confounders. Results The frequency of G allele was lower in Mulao than in Han (29.72% vs. 37.26%, P P P P P P P P P  Conclusions The present study suggests that the rs2072183 SNP in NPC1L1 gene and its association with serum lipid profiles are different between the Mulao and Han populations. The difference in serum lipid profiles between the two ethnic groups might partly result from different rs2072183 SNP or NPC1L1 gene-environmental interactions.

  15. Applications of RS, GPS and GIS to Forest Management in China

    李伟林; 肖波; 李郁

    2000-01-01

    Applications of remote sensing (RS), global positioning system (GPS), geographic information system(GIS) and combination of three-S techniques in the forest management are introduced. It indicates that,with the quickly improvement of the computer technique, the three-S system will become a very important part of the forestry management system.

  16. Synthesis, degradability, and cell affinity of poly (DL-lactide-co-RS-hydroxyethyl-beta-malolactonate).

    Wang, Liang; Jia, Xiaohua; Chen, Yongsheng; Che, Yongzhe; Yuan, Zhi

    2008-11-01

    Poly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate) (PLMAH), a novel functionalized polylactide with hydroxyl arms, was synthesized by a two-step reaction. DL-lactide (DLLA) and RS-benzyloxyethyl-beta-malolactonate were first copolymerized by ring-opening polymerization with Sn(Oct)(2) as catalyst to generate poly(DL-lactide-co-RS-benzyloxyethyl-beta-malolactonate) (PLMAB); next the benzyl protective groups of PLMAB were removed by the hydrogenation reaction catalyzed by Pd/C to generate the final polymer PLMAH. The composition and structure of PLMAB and PLMAH were characterized by (1)H and (13)C NMR. In vitro degradation experiments of PLMAH copolymers showed that the more RS-hydroxyethyl-beta-malolactonate (MAHE) content in the copolymer film, the faster the degradation occurred. The results of human umbilical vein endothelial cells (ECV-304) cultivated on PDLLA and PLMAH films suggested that among all the films, the PLMAH film containing 9.4 mol % MAHE had the highest cell attachment efficiency. PMID:18186058

  17. HEUS-RS applications study, volume 1. [for Titan 3 and Thor launch vehicles

    1972-01-01

    Studies are given for sizing and integrating a high energy upper stage restartable solid motor into a flight stage with various payloads for use with Titan 3 and Thor launch vehicles. Motor and stage configurations are given along with performance evaluation of the HEUS-RS with the space shuttle.

  18. Karakteristik Penderita Asma Bronkial Rawat Inap di RS. St. Elisabeth Medan Tahun 1999-2001

    Sitohang, Basaria R.

    2013-01-01

    Penyakit Asma Bronkial merupakan salah satu penyakit PPOM (Penyakit Paru Obstruktif Menahun) dimana prevalensinya semakin meningkat diseluruh dunia termasuk Indonesia. Penyebab Asma Bronkial adalah multifaktorial baik secara intrinsik maupun ekstrinsik. Untuk mengetahui karakteristik penderita Asma Bronkial dilakukan penelitian dengan desain cross secsional yang bersifat deskriptif dan datanya retrospektif 3 tahun (1999 - 2001) rawat inap di RS St. Elisabeth Medan yang berjumlah 105 orang dew...

  19. Exploring Strategies for Parallel Computing of RS Data Assimilation with SWAP-GA

    Shamim Akhter

    2007-01-01

    Full Text Available An agro-hydrological simulation model is useful for agriculture monitoring. One issue in running such model is parameter identification, especially when the target area is large such as provincial or country level. Remote Sensing (RS provides us with useful information over large area. RS cannot observe input parameters of agro-hydrological models directly. However, a method to estimate input parameters of such model from RS using data assimilation has been proposed by Ines[1] using the SWAP (Soil, Water, Atmosphere and Plant model. Genetic Algorithm (GA was used in this optimization process. The combined model of SWAP and GA is called SWAP-GA model. When dealing with sufficiently large and complex processing with RS data, single computers time processing extends to unacceptable limits. It becomes necessary to introduce methods for using higher processing power such as distributed computing. Cluster based computing support both high performance and load balancing parallel or distributed applications. Implementing SWAP-GA in Cluster computers will remove the computational time constraint, with this hypothesis three different parallel SWAP-GA approaches are proposed in this study. Distributed population (where GA will work on distributed manner, Distributed pixel (Pixels are processed in parallel and Mixed of distributed population and pixel model called Hybrid model. The technical considerations of implementing such methodologies are visited here.

  20. Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk

    Lurie, Galina; Wilkens, Lynne R; Thompson, Pamela J;

    2011-01-01

    The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium...

  1. Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis

    He LL

    2016-03-01

    Full Text Available Lanlan He,1,* Yong Wang2,* 1Emergency Department, Zhenjiang First People’s Hospital, Zhenjiang, People’s Republic of China; 2Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People’s Republic of China *Both authors contributed equally to this work Purpose: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Materials and methods: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. Results: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C>T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. Conclusion: This meta-analysis suggests that OPN rs11730582 C>T polymorphism is not associated with cancer susceptibility. Keywords: osteopontin, polymorphism, cancer, risk 

  2. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity.

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Dunning Hotopp, Julie; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J; Tettelin, Hervé; Wessels, Michael R

    2008-03-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together with data reported previously for strain NEM316, the results reveal a conserved 39-gene CsrRS regulon. In vitro phosphorylation-dependent binding of recombinant CsrR to promoter regions of both positively and negatively regulated genes suggests that direct binding of CsrR can mediate activation as well as repression of target gene expression. Distinct patterns of gene regulation in csrR versus csrS mutants in strain 2603V/R compared to 515 were associated with different hierarchies of relative virulence of wild-type, csrR, and csrS mutants in murine models of systemic infection and septic arthritis. We conclude that CsrRS regulates a core group of genes including important virulence factors in diverse strains of GBS but also displays marked variability in the repertoire of regulated genes and in the relative effects of CsrS signaling on CsrR-mediated gene regulation. Such variation is likely to play an important role in strain-specific adaptation of GBS to particular host environments and pathogenic potential in susceptible hosts. PMID:18203834

  3. MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

    Patel, V.S.; Kelly, S.; Wright, C.; Gupta, C.N.; Arias Vasquez, A.; Perrone-Bizzozero, N.; Ehrlich, S.; Wang, L.; Bustillo, J.R.; Morris, D.; Corvin, A.; Cannon, D.M.; McDonald, C.; Donohoe, G.; Calhoun, V.D.; Turner, J.A.

    2015-01-01

    Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of indi

  4. Common variant rs7579169 is associated with preeclampsia in Han Chinese women.

    Guo, L F; Wang, Z H; Wang, Y F

    2016-01-01

    As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP rs7579169 is associated with the susceptibility to preeclampsia through a case-control research model in Han Chinese women. Genotypes of 145 patients with preeclampsia and 150 healthy pregnant subjects were identified by direct sequencing. The correlation between the rs7579169 genotype and the susceptibility to preeclampsia was evaluated using an unconditional logistic regression model. Although there were no differences of having the rs7579169 SNP between early onset and late onset preeclampsia, patients carrying the CT or TT genotype were more likely to develop preeclampsia than those carrying the CC genotype (CT vs CC: OR = 1.76, 95%CI = 1.07-2.87, P Chinese women. PMID:27173354

  5. Genome Sequence of Penicillium solitum RS1, Which Causes Postharvest Apple Decay.

    Yu, Jiujiang; Wu, Guangxi; Jurick, Wayne M; Gaskins, Verneta L; Yin, Yanbin; Yin, Guohua; Bennett, Joan W; Shelton, Daniel R

    2016-01-01

    Penicillium species cause postharvest decay, commonly known as blue mold, in pome fruits, such as apples and pears. To devise novel strategies to prevent and reduce economic losses during storage, the genome sequence of Penicillium solitum RS1 is reported here for the first time. PMID:27174276

  6. HMGCR rs17671591 SNP Determines Lower Plasma LDL-C after Atorvastatin Therapy in Chilean Individuals.

    Cuevas, Alejandro; Fernández, César; Ferrada, Luis; Zambrano, Tomás; Rosales, Alexy; Saavedra, Nicolás; Salazar, Luis A

    2016-04-01

    Lipid-lowering response to statin therapy shows large interindividual variability. At a genome-wide significance level, single nucleotide polymorphisms (SNPs) in PCSK9 and HMGCR have been implicated in this differential response. However, the influence of these variants is uncertain in the Chilean population. Hence, we aimed to evaluate the contribution of PCSK9 rs7552841 and HMGCR rs17671591 SNPs as genetic determinants of atorvastatin response in Chilean hypercholesterolaemic individuals. One hundred and one hypercholesterolaemic patients received atorvastatin 10 mg/day for 4 weeks. Plasma lipid profile (TC, HDL-C, LDL-C and TG) was determined before and after statin treatment, and SNPs were identified by allelic discrimination using TaqMan(®) SNP Genotyping Assays. Adjusted univariate and multivariate analyses' models were used for statistical analyses, and a p-value atorvastatin therapy for the PCSK9 variant. However, the HMGCR rs17671591 T allele contributed to basal HDL-C concentration variability along with a higher increase in this lipid fraction after statin medication. In addition, this allele determined greater plasma LDL-C reductions after therapy with atorvastatin. Our data suggest that the HMGCR rs17671591 polymorphism can constitute a genetic marker of lower plasma LDL-C and enhanced HDL-C concentration after atorvastatin therapy in the Chilean population. PMID:26408409

  7. Integrable mappings derived from the $\\Delta \\Delta RsG$ equation

    Iatrou, Apostolos

    2003-01-01

    In this paper we consider the integrability of the mappings derived from the double discrete related sine-Gordon $(\\Delta \\Delta RsG)$ equation, which we recently introduced in the paper Higher dimensional integrable mappings, under an appropriate periodicity condition.

  8. INTEGRATION OF STORAGE CHARACTERISTIC WITH ON-LINE SERVICE CHARACTERISTIC OF AS/RS

    2001-01-01

    Directed at how to integrated storage characteristic with on-line service characteristic of AS/RS, a solution based on database design and programming method is proposed. The results show that this model is reasonable and applicable while using in some small or middle enterprises material handling system.

  9. Face and emotion expression processing and the serotonin transporter polymorphism 5-HTTLPR/rs22531.

    Hildebrandt, A; Kiy, A; Reuter, M; Sommer, W; Wilhelm, O

    2016-06-01

    Face cognition, including face identity and facial expression processing, is a crucial component of socio-emotional abilities, characterizing humans as highest developed social beings. However, for these trait domains molecular genetic studies investigating gene-behavior associations based on well-founded phenotype definitions are still rare. We examined the relationship between 5-HTTLPR/rs25531 polymorphisms - related to serotonin-reuptake - and the ability to perceive and recognize faces and emotional expressions in human faces. For this aim we conducted structural equation modeling on data from 230 young adults, obtained by using a comprehensive, multivariate task battery with maximal effort tasks. By additionally modeling fluid intelligence and immediate and delayed memory factors, we aimed to address the discriminant relationships of the 5-HTTLPR/rs25531 polymorphisms with socio-emotional abilities. We found a robust association between the 5-HTTLPR/rs25531 polymorphism and facial emotion perception. Carriers of two long (L) alleles outperformed carriers of one or two S alleles. Weaker associations were present for face identity perception and memory for emotional facial expressions. There was no association between the 5-HTTLPR/rs25531 polymorphism and non-social abilities, demonstrating discriminant validity of the relationships. We discuss the implications and possible neural mechanisms underlying these novel findings. PMID:27079569

  10. Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

    Hansen, Tue H; Vestergaard, Henrik; Jørgensen, Torben; Jørgensen, Marit Eika; Lauritzen, Torsten; Brandslund, Ivan; Christensen, Cramer; Pedersen, Oluf; Hansen, Torben; Gjesing, Anette P

    2015-01-01

    Background: The variant rs11085226 (G) within the gene encoding polypyrimidine tract binding protein 1 (PTBP1) was reported to associate with reduced insulin release determined by an oral glucose tolerance test (OGTT) as well as an intravenous glucose tolerance test (IVGTT). The aim of the present...

  11. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    Hollestelle, Antoinette; van der Baan, Frederieke H; Berchuck, Andrew;

    2016-01-01

    OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing part...

  12. X-ray crystal structure of divalent metal-activated ß-xyloisdase, RS223BX

    We report the first X-ray structure of a glycoside hydrolase family 43 ß-xylosidase, RS223BX, which is strongly activated by the addition of divalent metal cations. The 2.69 Å structure reveals that the Ca2+ cation is located at the back of the active site pocket. The Ca2+ coordinates to H274 to sta...

  13. Cosmological constant problem in a scenario with compactifications (RS-I model)

    Martinez-Robles, C

    2016-01-01

    In this letter, we apply the Randall-Sundrum (RS) model, a scenario based on compactifications, to control the UV divergence of the zero-point energy density equation for the vacuum fluctuations, which has been unsuccessfully addressed to the cosmological constant (CC) due to a heavy discrepancy between theory and observation. Historically, the problem of CC has been shelved in the RS point of view, having few or non literature on the subject. In this sense and as done with the hierarchy problem, we apply the RS model to solve this difference via extra dimensions; we also describe how brane effects could be the solution to this substantial difference. It should be noticed that this problem is studied assuming first Minkoswki type branes, and then followed by cosmologically more realistic FLRW type branes. We finally find some remarkably interesting consequences in the RS scenario: The CC problem can be solved via compactification of the extra dimension and the compactification radius turns out to be approxima...

  14. Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability

    Hadi Valizadeh

    2012-06-01

    Full Text Available Purpose: The purpose of this work was to preparation of vancomycin (VCM biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W multiple emulsion method. Methods: The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed for their micromeritic and crystallographic properties, drug loading, particle size, drug release, Zeta potential, effective permeability (Peff and oral fractional absorption. Intestinal permeability of VCM nanoparticles was figured out, in different concentrations using SPIP technique in rats. Results: Particle sizes were between 362 and 499 nm for different compositions of VCM-RS-100 nanoparticles. Entrapment efficiency expansed between 63%-94.76%. The highest entrapment efficiency 94.76% was obtained when the ratio of drug to polymer was 1:3. The in vitro release studies were accomplished in pH 7.4. The results showed that physicochemical properties were impressed by drug to polymer ratio. The FT-IR, XRPD and DSC results ruled out any chemical interaction betweenthe drug and RS-100. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 µg/ml were higher than that of solutions at the same concentrations. Oral fractional absorption was achieved between 0.419-0.767. Conclusion: Our findings suggest that RS-100 nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability.

  15. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes.

    Liu, Mu-En; Huang, Chu-Chung; Yang, Albert C; Tu, Pei-Chi; Yeh, Heng-Liang; Hong, Chen-Jee; Chen, Jin-Fan; Liou, Ying-Jay; Lin, Ching-Po; Tsai, Shih-Jen

    2013-01-01

    The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM) volume across the adult lifespan. Our sample comprised 330 healthy volunteers (191 male, 139 female) with a mean age of 56.2±22.0 years (range: 21-92). Magnetic resonance imaging and genotyping of the Bcl-2 rs956572 were performed for each participant. The differences in regional GM volumes between G homozygotes and A-allele carriers were tested using optimized voxel-based morphometry. The association between the Bcl-2 rs956572 polymorphism and age was a predictor of regional GM volumes in the right cerebellum, bilateral lingual gyrus, right middle temporal gyrus, and right parahippocampal gyrus. We found that the volume of these five regions decreased with increasing age (all P<.001). Moreover, the downward slope was steeper among the Bcl-2 rs956572 A-allele carriers than in the G-homozygous participants. Our data provide convergent evidence for the genetic effect of the Bcl-2 functional allelic variant in brain aging. The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis, conferred a protective effect against age-related changes in brain GM volume, particularly in the cerebellum. PMID:23437205

  16. Ranitidine hydrochloride-loaded ethyl cellulose and eudragit Rs 100 buoyant microspheres: Effect of ph modifiers

    N R Kotagale

    2011-01-01

    Full Text Available A floating type of dosage form of ranitidine hydrochloride in the form of microspheres capable of floating on simulated gastric fluid was prepared by solvent evaporation technique. Microspheres prepared with ethyl cellulose, Eudragit® RS100 alone or in combination were evaluated for percent yield, drug entrapment, percent buoyancy and drug release and the results demonstrated satisfactory performance. Microspheres exhibited ranitidine hydrochloride release influenced by changing ranitidine hydrochloride-polymer and ranitidine hydrochloride-polymer-polymer ratio. Incorporation of a pH modifier has been the usual strategy employed to enhance the dissolution rate of weakly basic drug from floating microspheres. Further citric acid, fumaric acid, tartaric acid were employed as pH modifiers. Microspheres prepared with ethyl cellulose, Eudragit® RS100 and their combination that showed highest release were utilized to study the effect of pH modifiers on ranitidine hydrochloride release from microspheres which is mainly affected due to modulation of microenvironmental pH. In vitro release of ranitidine hydrochloride from microspheres into simulated gastric fluid at 37° showed no significant burst effect. However the amount of release increased with time and significantly enhanced by pH modifiers. 15% w/w concentration of fumaric acid provide significant drug release from ranitidine hydrochloride microspheres prepared with ranitidine hydrochloride:ethyl cellulose (1:3, ranitidine hydrochloride:Eudragit® RS100 (1:2 and ranitidine hydrochloride:ethyl cellulose:Eudragit® RS100 (1:2:1 whereas citric acid, tartaric acid showed significant cumulative release at 20% w/w. In all this study suggest that ethyl celluose, Eudragit® RS100 alone or in combination with added pH modifiers can be useful in floating microspheres which can be proved beneficial to enhance the bioavailability of ranitidine hydrochloride.

  17. Expanding the three Rs to meet new challenges in humane animal experimentation.

    Schuppli, Catherine A; Fraser, David; McDonald, Michael

    2004-11-01

    The Three Rs are the main principles used by Animal Ethics Committees in the governance of animal experimentation, but they appear not to cover some ethical issues that arise today. These include: a) claims that certain species should be exempted on principle from harmful research; b) increased emphasis on enhancing quality of life of research animals; c) research involving genetically modified (GM) animals; and d) animals bred as models of disease. In some cases, the Three Rs can be extended to cover these developments. The burgeoning use of GM animals in science calls for new forms of reduction through improved genetic modification technology, plus continued attention to alternative approaches and cost-benefit analyses that include the large numbers of animals involved indirectly. The adoption of more expanded definitions of refinement that go beyond minimising distress will capture concerns for enhancing the quality of life of animals through improved husbandry and handling. Targeting refinement to the unpredictable effects of gene modification may be difficult; in these cases, careful attention to monitoring and endpoints are the obvious options. Refinement can also include sharing data about the welfare impacts of gene modifications, and modelling earlier stages of disease, in order to reduce the potential suffering caused to disease models. Other issues may require a move beyond the Three Rs. Certain levels of harm, or numbers and use of certain species, may be unacceptable, regardless of potential benefits. This can be addressed by supplementing the utilitarian basis of the Three Rs with principles based on deontological and relational ethics. The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research. PMID:15656775

  18. Association Between rs1344706 of ZNF804A and Schizophrenia:A Meta-analysis

    Meiyan Zhu; Tongyang Liu; Jihong Zhang; Shuting Jia; Wenru Tang; Ying Luo

    2014-01-01

    Schizophrenia is one of the most serious mental diseases found in humans. Previous studies indicated that the single nucleotide polymorphism (SNP) rs1344706 in the gene ZNF804A encoding zinc finger protein 804A was associated with schizophrenia in Caucasian population but not in Chinese Han population. However, current results are conflicting in Asian population. In the present study, a meta-analysis was performed to revisit the association between rs1344706 and the risk of schizophrenia in Asian, Caucasian and other populations. Electronic search of PubMed database identified 25 case–control studies with available genotype frequencies of rs1344706 for the meta-analysis, involving a total of 15,788 cases and 22,654 controls. A pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. The current meta-analysis showed an association between rs1344706 and schizophrenia in Caucasian populations (P= 0.028, OR= 1.138, 95% CI: 1.014–1.278; P = 0.004 for heterogeneity) and Asian populations (P = 0.008, OR = 1.092, 95% CI: 1.023–1.165; P = 0.001 for heterogeneity), but not in other populations (P= 0.286, OR= 1.209, 95% CI: 0.853–1.714, P = 0.120 for heterogeneity). Egger’s test (P > 0.05) and Begg’s test (P>0.05) are both suggestive of the lack of publication bias for the included studies. Thus, the absence of association in other populations suggests a genetic heterogeneity in the susceptibility of schizophrenia and demonstrates the difficulties in replicating genome-wide association study findings regarding schizophrenia across different ethnic populations. To validate the association between rs1344706 and schizophrenia, further studies with larger participant populations worldwide are needed.

  19. Synchronization, TIGoRS, and Information Flow in Complex Systems: Dispositional Cellular Automata.

    Sulis, William H

    2016-04-01

    Synchronization has a long history in physics where it refers to the phase matching of two identical oscillators. This notion has been extensively studied in physics as well as in biology, where it has been applied to such widely varying phenomena as the flashing of fireflies and firing of neurons in the brain. Human behavior, however, may be recurrent but it is not oscillatory even though many physiological systems do exhibit oscillatory tendencies. Moreover, much of human behaviour is collaborative and cooperative, where the individual behaviours may be distinct yet contemporaneous (if not simultaneous) and taken collectively express some functionality. In the context of behaviour, the important aspect is the repeated co-occurrence in time of behaviours that facilitate the propagation of information or of functionality, regardless of whether or not these behaviours are similar or identical. An example of this weaker notion of synchronization is transient induced global response synchronization (TIGoRS). Previous work has shown that TIGoRS is a ubiquitous phenomenon among complex systems, enabling them to stably parse environmental transients into salient units to which they stably respond. This leads to the notion of Sulis machines, which emergently generate a primitive linguistic structure through their dynamics. This article reviews the notion of TIGoRS and its expression in several complex systems models including tempered neural networks, driven cellular automata and cocktail party automata. The emergent linguistics of Sulis machines are discussed. A new class of complex systems model, the dispositional cellular automaton is introduced. A new metric for TIGoRS, the excess synchronization, is introduced and applied to the study of TIGoRS in dispositional cellular automata. It is shown that these automata exhibit a nonlinear synchronization response to certain perturbing transients. PMID:27033136

  20. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes.

    Mu-En Liu

    Full Text Available The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2 gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM volume across the adult lifespan. Our sample comprised 330 healthy volunteers (191 male, 139 female with a mean age of 56.2±22.0 years (range: 21-92. Magnetic resonance imaging and genotyping of the Bcl-2 rs956572 were performed for each participant. The differences in regional GM volumes between G homozygotes and A-allele carriers were tested using optimized voxel-based morphometry. The association between the Bcl-2 rs956572 polymorphism and age was a predictor of regional GM volumes in the right cerebellum, bilateral lingual gyrus, right middle temporal gyrus, and right parahippocampal gyrus. We found that the volume of these five regions decreased with increasing age (all P<.001. Moreover, the downward slope was steeper among the Bcl-2 rs956572 A-allele carriers than in the G-homozygous participants. Our data provide convergent evidence for the genetic effect of the Bcl-2 functional allelic variant in brain aging. The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis, conferred a protective effect against age-related changes in brain GM volume, particularly in the cerebellum.

  1. Optical isolation and surge protection of RS-232 port%RS-232端口光电隔离型电涌保护器

    王金虎; 李祥超; 刘晓东; 黄鹏良

    2011-01-01

    根据气体放电管和瞬态抑制二极管的保护特性,合理选择退耦元件参数,实现多级SPD间的能量配合,并结合光纤的保护性能设计RS-232接口的保护电路.最后利用雷电冲击试验平台LST-6kV/3 kA、ICGS冲击平台以及DF1641C函数发生器对保护电路进行实验,以验证设计的方案.实验结果表明:在加上保护器件后,通信端口的抗雷电过压能力得到了很大的提高,并且加入该保护电路以后基本不会对原电路产生插入损耗.%Lightning over-voltages are the important reasons for losses in communication port, which make it neces-sary and urgent to study into the lightning protection of communication port. According to the protection characteris-tics of gas discharge tube and transient voltage suppressor, the decoupling components are selected carefully to a-chieve the rational energy correspondence between multi-level SPD. Besides that,optical design is also considered to design protective circuit of RS-232 port. Finally,in order to verify the design scheme,the lightning impact platform called LST-6 kV/3 kA and ICGS and function generator called DF1641C are employed for the experiments. The ex-periments show that bearing capacity of lightning over-voltage of communication port RS-232 has been greatly im-proved and will not produce insertion loss to original circuit by adding the protection circuit.

  2. Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.

    Cita, Kizzy-Clara; Ferdinand, Séverine; Connes, Philippe; Brudey, Laura; Tressières, Benoit; Etienne-Julan, Maryse; Lemonne, Nathalie; Tarer, Vanessa; Elion, Jacques; Romana, Marc

    2016-05-01

    A recent study suggested that adenosine signaling pathway could promote hemolysis in patients with sickle cell anemia (SCA). This signaling pathway involves several gene coding enzymes for which variants have been described. In this study, we analyzed the genotype-phenotype relationships between functional polymorphisms or polymorphisms associated with altered expression of adenosine pathway genes, namely adenosine deaminase (ada; rs73598374), adenosine A2b receptor (adora2b; rs7208480), adenylyl cyclase6 (adcy6; rs3730071, rs3730070, rs7300155), and hemolytic rate in SCA patients. One hundred and fifty SCA patients were genotyped for adcy6, ada, and adora2b variants as well as alpha-globin gene, a genetic factor known to modulate hemolytic rate. Hematological and biochemical data were obtained at steady-state. Lactate dehydrogenase, aspartate aminotransferase, reticulocytes and total bilirubin were used to calculate a hemolytic index. Genotype-phenotype relationships were investigated using parametric tests and multivariate analysis. SCA patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). The presence of adcy6 rs3730070-G variant was associated with a decreased hemolytic rate in adjusted model for age and alpha-thalassemia (p=0.032). Our results support a protective effect of adcy6 rs3730070-G variant on hemolysis in SCA patients. PMID:27067484

  3. 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer

    Warren, Helen; Dudbridge, Frank; Fletcher, Olivia;

    2012-01-01

    Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).......Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686)....

  4. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

    Campa, Daniele; Hüsing, Anika; McKay, James D.; Sinilnikova, Olga; Vogel, Ulla Birgitte; Tjønneland, Anne; Overvad, Kim; Stegger, Jakob; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Fagherazzi, Guy; Trichopoulou, Antonia; Zylis, Dimosthenis; Oustoglou, Erifili; Rohrmann, Sabine; Teucher, Birgit; Fisher, Eva; Bouing, Heiner; Masala, Giovanna; Eustoglou, Vittorio; Sacerdote, Carlotta; Panico, Salvatore; Tumino, Rosario; Onland-Moret, Charlotte; H van Gils, Carla; Bueno-de-Mesquita, H Bas; Lund, Eiliv; Dolores Chirlaque, María; Sala, Núria; Ramon Quirós, José; Ardanaz, Eva; Amiano, Pilar; Molina-Montes, Esther; Hallmans, Göran; Lenner, Per; C. Travis, Ruth; Key, Timothy J; Wareham, Nick; Khaw, Kay-Tee; Rinaldi, Sabina; Slimani, Nadia; Chajes, Veronique; Siddiq, Afshan; Riboli, Elio; Kaaks, Rudolf; Canzian, Federico

    2010-01-01

    Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fat...

  5. Association of a single nucleotide polymorphism rs821597 in gene disrupted-in-schizophrenia-1 with white matter integrity

    魏钦令

    2014-01-01

    Objective To explore the association of a single nucleotide polymorphism(SNP)rs821597 in gene disrupted-in-schizophrenia-1(DISC1)with white matter integrity in healthy people.Methods Sixty healthy persons were genotyped at the SNP rs821597 in DISC1 and were divided into two groups(risk allele carriers and non-risk allele

  6. A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease

    Rui Liu

    2014-01-01

    Full Text Available Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A, C-reactive protein (rs1800947 and rs3093059 T/C, methylenetetrahydrofolate reductase (rs1801133, C/T, and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population. Genotyping was performed using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method. When the HNF1A rs7310409 GG homozygote genotype was used as the reference group, both the individual, GA and AA, and combined GA/AA genotypes were associated with an increased risk of LMCAD. This single nucleotide polymorphism (rs7310409 is strongly associated with plasma CRP levels. In conclusion, the present study provides evidence that the HNF1A rs7310409 G/A functional polymorphism may contribute to the risk of LMCAD.

  7. Structures of Ionic Liquids Dictate the Conversion and Selectivity of Enzymatic Glycerolysis: Theoretical Characterization by COSMO-RS

    Guo, Zheng

    2008-01-01

    quantitatively associated with the structural characteristics of the IL by means of quantum chemical and COSMO-RS calculation. Misfit interaction, Van der Waals interaction and chemical potential, etc. derived from COSMO-RS calculation are shown to be effective measures to delineate multiple interactions of ILs...

  8. 78 FR 20386 - Notice of Receipt of Petition for Decision That Nonconforming 2012 Porsche GT3RS Passenger Cars...

    2013-04-04

    ... Nonconforming 2012 Porsche GT3RS Passenger Cars Are Eligible for Importation AGENCY: National Highway Traffic... Porsche GT3RS passenger cars that were not originally manufactured to comply with all applicable Federal... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). How...

  9. Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

    Annys, Erwin; Billington, Richard; Clayton, Rick; Bremm, Klaus-Dieter; Graziano, Michael; McKelvie, Jo; Ragan, Ian; Schwarz, Michael; van der Laan, Jan Willem; Wood, Charles; Öberg, Mattias; Wester, Piet; Woodward, Kevin N

    2014-07-01

    Different government agencies operating in the European Union regulate different types of chemical products but all require testing for carcinogenicity to support applications for product marketing and commercialisation. A conference was held in Brussels in 2013 where representatives of the pharmaceutical, animal health, chemical and plant protection industries, together with representatives of regulatory agencies, universities and other stakeholders, met under the auspices of The European Partnership for Alternative Approaches to Animal Testing (EPAA) to discuss the varying requirements for carcinogenicity testing, and how these studies might be refined to improve hazard evaluation and risk assessment while implementing principles of the 3Rs (replacement, refinement and reduction in animal studies). While there are some similarities, the regulatory approaches in pharmaceutical, animal health, chemical and plant protection sectors have varying degrees of flexibility in requirements for carcinogenicity testing, to an extent reflecting concerns over the magnitude and duration of human exposure, either directly as in therapeutic exposure to pharmaceuticals, or indirectly through the ingestion of residues of veterinary drugs or plant protection chemicals. The article discusses these differences and other considerations for modified carcinogenicity testing paradigms on the basis of scientific and 3Rs approaches. PMID:24768934

  10. Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.

    Janett Fischer

    Full Text Available BACKGROUND & AIMS: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B are the most powerful predictors for sustained virologic response (SVR in patients with chronic hepatitis C virus (HCV infection, compared to other biochemical or histological baseline parameters. We evaluated whether the interplay of both IFNL3 polymorphisms rs12979860 and rs8099917 together with non-genetic clinical factors contributes to the predictive role of these genetic variants. METHODS: The cohort comprised 1,402 patients of European descent with chronic HCV type 1 infection. 1,298 patients received interferon-based antiviral therapy, and 719 (55% achieved SVR. The IFNL3 polymorphisms were genotyped by polymerase chain reaction and melting curve analysis. RESULTS: A significant correlation was found between the IFNL3 polymorphisms and biochemical as well as virologic predictors of treatment outcome such as ALT, GGT, cholesterol, and HCV RNA levels. In multivariate regression analysis, IFLN3 SNPs, HCV RNA levels, and the GGT/ALT ratio were independent predictors of SVR. Dependent on the GGT/ALT ratio and on the HCV RNA concentration, significant variations in the likelihood for achieving SVR were observed in both, carriers of the responder as well as non-responder alleles. CONCLUSIONS: Our data support a clear association between IFNL3 genotypes and baseline parameters known to impact interferon responsiveness. Improved treatment outcome prediction was achieved when these predictors were considered in combination with the IFNL3 genotype.

  11. Conductor-Like Screening Model for Real Solvents (COSMO-RS)%真实溶剂似导体屏蔽模型(COSMO-RS)

    牟天成; Jürgen Gmenhling

    2008-01-01

    真实溶剂似导体屏蔽模型(COSMO-RS, Conductor-like screening model for real solvents)是Klamt等在连续介质溶剂化模式COSMO的基础上,结合统计力学方法发展起来的定量计算溶剂化现象的新方法.本文简单介绍了COSMO-RS的基本原理、概念,以及应用该模式的基本步骤.综述了COSMO-RS应用于离子性化合物、聚合物溶液体系、高温高压体系以及预测复杂生物体系的分配系数和药物设计的进展.评述了简化分子表面屏蔽电荷分布计算的COSMOfrag和GC-COSMO (group contribution COSMO)方法,对不同版本的COSMO-RS之间以及其与基团贡献方法的对比研究也作了详细的讨论,并指出了COSMO-RS的不足之处和进一步发展该模式的建议.

  12. Tvisten om försäkringsskyddet mellan säkerhetskoncernen Securitas och If Skadeförsäkring AB efter händelserna den 11 september 2001

    Beigler, Louise

    2006-01-01

    Ett av de flygplan som flögs in i World Trade Center i New York, USA, den 11 september 2001 lyfte från Bostons flygplats. Säkerheten på flygplatsen var Globe, ett bolag i Securitaskoncernen, ansvarigt för. Securitaskoncernen, däribland Globe, ville med anledning av att ett antal skadeståndsanspråk, som följde efter attacken den 11 september 2001, ha försäkringsskydd ur det globala försäkringsprogram som Securitaskoncernen tecknat hos If Skadeförsäkring AB. Ett skiljeförfarande inleddes mellan...

  13. Vitamin D3 receptor ( VDR gene rs2228570 (Fok1 and rs731236 (Taq1 variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis.

    Elena García-Martín

    Full Text Available BACKGROUND: Some epidemiological, genetic, and experimental data suggest a possible role of vitamin D in the pathogenesis of multiple sclerosis (MS and in experimental autoimmune encephalomyelitis. Data on the possible contribution of several single nucleotide polymorphisms (SNP in the vitamin D receptor (VDR gene to the risk for MS are controversial. Several studies suggested an interaction between some SNPs in the VDR gene and HLADRB1*1501 in the risk for MS. OBJECTIVES: The aim of this study was to investigate a possible influence of the SNPs rs2228570 and rs731236 in the VDR gene in the risk for MS. A secondary objective was to address the possible interactions between VDR genes and HLADRB1*1501. METHODS: We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388 in 303 patients with MS and 310 healthy controls, using TaqMan Assays. We also conducted a meta-analysis, that was carried out by using the software Meta-Disc 1.1.1 (http://www.hrc.es/investigacion/metadisc.html; Unit of Clinical Statistics, Hospital Ramón y Cajal, Madrid, Spain. Heterogeneity between studies in terms of degree of association was tested using the Q-statistic. RESULTS: VDR rs2228570 and rs731236 allelic and genotype frequencies did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. HLADRB1*1501 showed a high association with the risk of developing MS 4.76(95% C.I.  = 3.14-7.27; p<0.0001. The meta-analysis, after excluding data of one study that was responsible of heterogeneity for rs731236 polymorphism, showed lack of relation of both SNPs with the risk for MS. HLADRB1*1501 showed lack of interaction with VDR rs2228570 and rs731236 in increasing MS risk. CONCLUSIONS: These results suggest that VDR rs2228570 and rs731236 polymorphisms are not related with the risk for MS, and did not confirm interaction between these VDR SNPs and HLADRB1

  14. The NOD2 p.Leu1007fsX1008 mutation (rs2066847 is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.

    Fabian Schnitzler

    Full Text Available BACKGROUND: Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD (Cell 2013;155:57-69. The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery. METHODOLOGY/PRINCIPAL FINDINGS: We genotyped 550 CD patients for rs12212067 (FOXO3A and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses. RESULTS: No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847 was highly associated with penetrating CD (p = 0.01, the development of fistulas (p = 0.01 and stenoses (p = 0.01, and ileal disease localization (p = 0.03. Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5, while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35. 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p = 0.007. CONCLUSION/SIGNIFICANCE: In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847, in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A

  15. Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA.

    Knafo, A; Israel, S; Darvasi, A; Bachner-Melman, R; Uzefovsky, F; Cohen, L; Feldman, E; Lerer, E; Laiba, E; Raz, Y; Nemanov, L; Gritsenko, I; Dina, C; Agam, G; Dean, B; Bornstein, G; Ebstein, R P

    2008-04-01

    Human altruism is a widespread phenomenon that puzzled evolutionary biologists since Darwin. Economic games illustrate human altruism by showing that behavior deviates from economic predictions of profit maximization. A game that most plainly shows this altruistic tendency is the Dictator Game. We hypothesized that human altruistic behavior is to some extent hardwired and that a likely candidate that may contribute to individual differences in altruistic behavior is the arginine vasopressin 1a (AVPR1a) receptor that in some mammals such as the vole has a profound impact on affiliative behaviors. In the current investigation, 203 male and female university students played an online version of the Dictator Game, for real money payoffs. All subjects and their parents were genotyped for AVPR1a RS1 and RS3 promoter-region repeat polymorphisms. Parents did not participate in online game playing. As variation in the length of a repetitive element in the vole AVPR1a promoter region is associated with differences in social behavior, we examined the relationship between RS1 and RS3 repeat length (base pairs) and allocation sums. Participants with short versions (308-325 bp) of the AVPR1a RS3 repeat allocated significantly (likelihood ratio = 14.75, P = 0.001, df = 2) fewer shekels to the 'other' than participants with long versions (327-343 bp). We also implemented a family-based association test, UNPHASED, to confirm and validate the correlation between the AVPR1a RS3 repeat and monetary allocations in the dictator game. Dictator game allocations were significantly associated with the RS3 repeat (global P value: likelihood ratio chi(2) = 11.73, df = 4, P = 0.019). The association between the AVPR1a RS3 repeat and altruism was also confirmed using two self-report scales (the Bardi-Schwartz Universalism and Benevolence Value-expressive Behavior scales). RS3 long alleles were associated with higher scores on both measures. Finally, long AVPR1a RS3 repeats were associated with

  16. Konkursgäldenärs skiljeavtal : när binder avtalet konkursboet?

    Persson, Emilia; Larsson, Nina

    2014-01-01

    Syftet med denna kandidatuppsats är att beskriva gällande rätt kring om och när en konkursgäldenärs skiljeavtal binder dess konkursbo samt konsekvenserna av detta. I dagsläget är rättsområdet osäkert och enbart grundat på praxis, uppsatsen utreder därför även om lagstiftning eller annan utveckling på området är erforderlig. Det har i praxis konstaterats att en konkursgäldenärs skiljeavtal binder dess konkursbo då tvister gäller obligationsrättsliga anspråk och bevakningsförfaranden är aktuell...

  17. Developments on the implementation of the Three Rs in research and education.

    van Zutphen, L F; van der Valk, J B

    2001-01-01

    More than 40 years ago, Russell and Burch published their views on the implementation of the 'Three Rs' in animal experimentation. Since then, much has been achieved in this area. Recently, the European Science Foundation (ESF) has made a further step forward. In a position paper on the use of animals, ESF has formulated what it sees as prerequisites for the humane use of animals in research, testing and education. In this paper, we briefly report on these ESF guidelines. Also, an overview is presented on European legislative regulations for the (ethical) review of research protocols and for the education and training of persons involved in animal experiments. The great diversity between countries is illustrated with some examples and the need for harmonization is emphasised. The paper ends by highlighting the special role that editorial boards of journals can play in the further implementation of the Three Rs. PMID:11566596

  18. The political culture in Porto Alegre/RS: the PT and PMDB sympathizers

    Bianca de Freitas Linhares

    2009-12-01

    Full Text Available There are many and different approaches used in Political Science to work with political parties, and most of them with an institutionalist character. In order to broaden the discussion in another direction, this article aims to verify if there are differences of political culture between voters sympathizers of political parties in the city of Porto Alegre/RS. This research helps in understanding the reasons that lead some parties to have greater mobilization of supporters in certain times. For this purpose, data are used from a survey conducted in Porto Alegre/RS in 2005. These data represent the tripod: interest-confidence-political participation. It is the assumption that voters of the left parties have a profile more cooperative, more confidence and interest in politics, hypothesis which is confirmed.

  19. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer

    Amankwah, Ernest K; Kelemen, Linda E; Wang, Qinggang;

    2011-01-01

    BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.......0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study.......1-1.5, P(trend) = 0.003). METHODS: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. RESULTS: No evidence for an association with all cancers or serous cancers was observed in a...

  20. Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb.

    Dietschi, Quentin; Assens, Alexis; Challet, Ludivine; Carleton, Alan; Rodriguez, Ivan

    2013-09-01

    In the mouse, most members of the FPR receptor family are expressed by vomeronasal sensory neurons. The neural circuitry corresponding to this class of chemical sensors is unknown. Taking advantage of the presence of FPR-rs3 on both vomeronasal dendrites and axonal fibers, we visualized the distribution of sensory cells expressing this member of the FPR family, and their corresponding axonal projections in the olfactory bulb. We found a rostrocaudal gradient of receptor choice frequency in the vomeronasal sensory neuroepithelium, and observed a convergence of FPR-rs3 axons into multiple, linked and deeply located glomeruli. These were homogenously innervated, and spatially restricted to the basal portion of the rostral accessory olfactory bulb. This organization, reminiscent of the one that characterizes axonal projections of V1R-expressing neurons, supports a role played by these receptors in the perception of semiochemicals. PMID:23664818

  1. Promoting the 3Rs to enhance the OECD fish toxicity testing framework.

    Hutchinson, Thomas H; Wheeler, James R; Gourmelon, Anne; Burden, Natalie

    2016-04-01

    Fish toxicity testing has been conducted since the 1860's in order to help define safe levels of chemical contaminants in lakes, rivers and coastal waters. The historical emphasis on acute lethality testing of chemicals has more recently focussed on long term sublethal effects of chemicals on fish and their prey species. Fish toxicity testing is now embedded in much environment legislation on chemical safety while it is recognized that animal use should be Replaced, Reduced and Refined (the 3Rs) where possible. The OECD Fish Toxicity Testing Framework provides a useful structure with which to address the needs of environmental safety assessment whilst implementing the 3Rs. This commentary aims to promote the implementation of the recommendations of the OECD Fish Toxicity Testing Framework. PMID:26873775

  2. Predicting pKa for proteins using COSMO-RS

    Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane

    2013-01-01

    We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 p......H units. The results show that the accuracy of pKa prediction using COSMO-RS is as good for large biomolecules as it is for smaller inorganic and organic acids and that the method compares very well to previous pKa predictions of the OMTKY3 protein using Quantum Mechanics/Molecular Mechanics. Our approach...

  3. Optical Flickering of the recurrent nova RS Ophiuchi: amplitude - flux relation

    Zamanov, R; Boeva, S; Sokoloski, J L; Stoyanov, K; Bachev, R; Spassov, B; Ibryamov, S; Nikolov, G

    2015-01-01

    We report observations of the flickering variability of the symbiotic recurrent nova RS Oph at quiescence in five bands (UBVRI). We find evidence of correlation between the peak-to-peak flickering amplitude (\\Delta F) and the average flux of the hot component ($F_{av}$). The correlation is highly significant with correlation coefficient 0.85 and p-value $\\sim 10^{-15}$. Combining the data from all wavebands, we find a dependence of the type $\\Delta F \\propto F_{av}^k$, with power-law index $k = 1.02 \\pm 0.04$ for the UBVRI flickering of RS Oph. Thus, the rms amplitude of variability scale almost linearly with the average flux of the hot component, $ = 0.08 \\pm 0.02$. The detected correlation is similar to that found in some X-ray binaries. The possible reasons are briefly discussed. The data are available upon request from the authors.

  4. Konstruktion av strömförsörjningsmodul till testsystem

    Vidlid, Marija

    2015-01-01

    Detta examensarbete är utfört vid den tekniska högskolan vid Linköping Universitet på programmet högskoleingenjör elektronik. Uppdragsgivaren, Flextronics, är ett företag som utvecklar generell testutrustning inom elektronikproduktion. Den testutrustning som finns behöver uppdateras och examensarbetet går ut på att bygga en ny strömförsörjningsmodul till denna. Den största skillnaden mot tidigare system är att den nya strömförsörjningsmodulen ska klara av högre uteffekt. Eftersom den nya test...

  5. ANALYSIS OF SPECTRAL CHARACTERISTICS AMONG DIFFERENT SENSORS BY USE OF SIMULATED RS IMAGES

    2000-01-01

    This research, by use of RS image-simulating method, simulated apparent reflectance images at sensor level and ground-reflectance images of SPOT-HRV,CBERS-CCD,Landsat-TM and NOAA14-AVHRR' s corresponding bands. These images were used to analyze sensor's differences caused by spectral sensitivity and atmospheric impacts. The differences were analyzed on Normalized Difference Vegetation Index(NDVI). The results showed that the differences of sensors' spectral characteristics cause changes of their NDVI and reflectance. When multiple sensors' data are applied to digital analysis, the error should be taken into account. Atmospheric effect makes NDVI smaller, and atn~pheric correction has the tendency of increasing NDVI values. The reflectance and their NDVIs of different sensors can be used to analyze the differences among sensor' s features. The spectral analysis method based on RS simulated images can provide a new way to design the spectral characteristics of new sensors.

  6. Renal DMSA scintigraphy (RS) and direct radionuclide cystogram (DRC) in children with recurrent urinary tract infections (UTI): retrospective study

    Material and Methods: We analysed the results of RS and DRC in 92 children ( 82 % females ) with ages ranging from 1 month - 12 years old, mean: 4.3 years old. RS and DRC techniques were performed conventionally with a gamma-camera computer system. We determined the concordance or discordance between them, and the positive and negative predictive value of one method with respect to the other. For statistical analysis we used Chi square test. Results: We found a concordance of the results in both techniques in 69.5 %, with predominance of concordant normality 70%. In discordant results there were a predominance of abnormal RS with negative DRC in 78.6 %. The differences in this distribution was significant (p< 0.001). The predictive value of RS vs DRC was: PPV: 46 %, NPV: 88%. The predictive value of DRC vs RS was : PPV : 76 %, NPV: 67%. Conclusions: In children with recurrent urinary tract infection, our data support that: 1.- The normality of RS is a better predictor of normality than DRC. 2.- The abnormality of DRC predicts better the abnormality of RS than the inverse. 3.- The results of both techniques show a significant concordance

  7. Health Relationship Management Services (HRMS). A New Healthcare Paradigm Using the 5Rs

    Nik Tehrani

    2016-01-01

    Health Relationship Management Services (HRMS) is a new paradigm comprised of the 5Rs which define a comprehensive patient healthcare system in the digital health age. This service uses a health monitoring system with sensors and a patient application portal that can Read data and securely send it to the cloud with amended data from Electronic Health Records (EHR). The read data is Restructured by analytics software for evaluation and personalization in an aggregated form represented by an ...

  8. Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging

    Introduction: The most abundant subtype of cerebral nicotinic acetylcholine receptors (nAChR), α4β2, plays a critical role in various brain functions and pathological states. Due to rapid technological progress in chemistry, bioinformatics, structural biology and computer technology, computer aided drug design (CADD) plays a more and more important role in today's drug discovery. Methods: Two novel 3-pyridyl ether nicotinic ligands-3-((pyridine-2-yl)methoxy)-5-iodopyridine, and 3-(((S)-pyrrolidin-2-yl)methoxy)-5-((4-iodobenzyloxy)-methyl)pyridine were designed and synthesized and radiolabeled with I-125 based on our 3D-QSAR models reported previously. Their ability to label high-affinity brain nicotinic acetylcholine receptors (nAChRs) was evaluated. Results: [125I]3-((pyridin-2-yl)methoxy)-5-iodopyridine shows rapid accumulation and elimination with peak (1.86%ID/g) at 5 min post injection, but has high blood uptake. [125I]3-(((S)-pyrrolidin-2-yl)methoxy)-5-((4-iodobenzyloxy)methyl)pyridine entered the brain with maximal uptake value 3.01%ID/g at 15 min after injection, and showed approximately 27% inhibition of radioactivity uptake in thalamus in mice pretreated with nicotine. Conclusions: The results of this preliminary study show that [125I]3-(((S)-pyrrolidin-2-yl)methoxy)-5-((4-iodobenzyloxy)methyl)pyridine shows relatively high uptake to the brain, however, since the in vivo selectivity for α4β2 nAChRs was not enough, [125I]3-(((S)-pyrrolidin-2-yl)methoxy)-5-((4-iodobenzyloxy)methyl)pyridine does not have the required properties for imaging nAChRs using SPECT. Structure optimization is needed for specific visualization of brain α4β2 nAChRs in vivo.

  9. Overview of the ARIES-RS reversed-shear tokamak power plant study

    The ARIES-RS tokamak is a conceptual, D-T-burning 1000 MWe power plant. As with earlier ARIES design studies, the final design of ARIES-RS was obtained in a self-consistent manner using the best available physics and engineering models. Detailed analyses of individual systems together with system interfaces and interactions were incorporated into the ARIES systems code in order to assure self-consistency and to optimize towards the lowest cost system. The ARIES-RS design operates with a reversed-shear plasma and employs a moderate aspect ratio (A=4.0). The plasma current is relatively low (Ip=11.32 MA) and bootstrap current fraction is high (fBC=0.88). Consequently, the auxiliary power required for RF current drive is relatively low (∝80 MW). At the same time, the average toroidal beta is high (β=5%), providing power densities near practical engineering limits (the peak neutron wall loading is 5.7 MW m-2). The toroidal-field (TF) coil system is designed with relatively 'conventional' materials (Nb3Sn and NbTi conductor with 316SS structures), and is operated at a design limit of ∝16 T at the coil in order to optimize the design point. The ARIES-RS design uses a self-cooled lithium blanket with vanadium alloy as the structural material. The V-alloy has low activation, low afterheat, high temperature capability and can handle high heat flux. A self-cooled liquid lithium blanket is simple, and with the development of an insulating coating, has low operating pressure. Also, this blanket gives excellent neutronics performance. Detailed analysis has been performed to minimize the cost and maximize the performance of the blanket and shield. (orig.)

  10. The Method and Key Technology of Dynamic RS-GIS Environment Monitoring

    Chen, Jianping; Xiang, Jie; Tarolli, Paolo; Lai, Zili

    2016-04-01

    Demographic growth, socio-economic development and urbanization have resulted in excessive exploitation and exerted increasing pressure on limited resources and the fragile ecological environment in China. There is an urgent need for theory and technology to achieve the comprehensive evaluation of environment. Remote sensing is one of the most important technology to monitor and evaluate environment. This study summed up dynamic RS (Remote Sensing)-GIS (Geographic Information System) environment monitoring theory, and established a dynamic monitoring system, adopting comprehensive methods of multi-source, multi-scale and multi-temporal remote sensing data acquisition. A software system is developed based on RS-GIS analysis method to support the whole dynamic monitoring and evaluation theory. The main work and results obtained are as follows: 1)Summarized the evaluation theory of dynamic RS-GIS environment monitoring, using remote sensing technology as the main method to monitor environment; 2) established an advanced space-air-ground digital terrain data acquisition and processing technology (advanced satellite constellations, airborne and terrestrial laser scanner, low-cost Structure from Motion (SfM), photogrammetry, Unmanned Aerial Vehicle (UAV) and ground camera surveys); 3) Deeply study the application of quantitative digital terrain analysis in the assessment of environment, which successfully position geological disaster information and automatically extracted information; 4) Developed the RESEE software to support the whole dynamic monitoring and evaluation theory based on 4D-GIS; 5) A demonstration study of the dynamic monitoring environment is carried out in Beijing Miyun Iron Mine. Results show that the space-air-ground integrated and dynamic RS-GIS environment monitoring method and key technology can realize the positioning and quantitative monitoring the environment problem, and realize the risk assessment of the geological hazard.

  11. HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

    2014-01-01

    Background. HLA-G molecules exhibit immunomodulatory properties that can delay graft rejection. The 14 bp insertion/deletion polymorphism (INDEL) (rs16375) influences the stability of final HLA-G mRNA and its soluble isoforms. Objective. The present study aimed to investigate the possible association between this polymorphism and the incidence of acute rejection in Iranian liver transplant recipients. Methods. Different genotypes were evaluated by PCR. The patients who had acute rejection wit...

  12. Association of Wilms' tumor 1 gene single-nucleotide polymorphism rs16754 with colorectal cancer

    SANGKHATHAT, SURASAK; MANEECHAY, WANWISA; CHAIYAPAN, WELAWEE; KANNGERN, SAMORNMAS; BOONPIPATTANAPONG, TEERANUT

    2015-01-01

    Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Our recent study demonstrated that the expression of Wilms' tumor 1 gene (WT1) is associated with surgical outcome in CRC patients. The present study aimed to investigate the genetic association of the single-nucleotide polymorphism rs16754 in the WT1 gene with the occurrence of CRC, using an age-matched case-control study design. In addition, the correlation between genotype and WT1 expression was investigated. Genomic DNA samples from 104 CRC cases, aged 15–65 years, and 208 healthy controls, were genotyped for rs16754 using the TaqMan genotyping method. The genotype distribution conformed to the Hardy-Weinberg equilibrium (P=0.80). The overall minor allele frequency (MAF) of rs16754 (allele A) was 0.33. The MAF among CRC cases was significantly higher compared with that in controls (0.39 vs. 0.31, respectively; P=0.03). The AA genotype was significantly associated with the disease (odds ratio = 2.51, 95% confidence interval: 1.24–5.07, P=0.01). Cases with the AA genotype exhibited a significantly poorer 3-year overall survival (60%), compared with those with the GG or GA genotypes (80%) (log-rank test, P<0.01). Reverse transcription quantitative polymerase chain reaction analysis demonstrated that the expression of WT1 in tumor tissues was higher compared with that in normal tissue; however, there were no significant differences in its expression among different genotypes. Therefore, rs16754 was found to be associated with the occurrence and prognosis of CRC in our subjects. PMID:26807256

  13. Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development

    Bizuayehu Teshome T

    2012-01-01

    Full Text Available Abstract Background MicroRNAs (miRNAs play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. Developmental profiles of miRNAs have been reported in few fish species only and, to our knowledge, differential expressions of isomiRs have not yet been shown during fish development. Atlantic halibut, Hippoglossus hippoglossus L., undergoes dramatic metamorphosis during early development from symmetrical pelagic larval stage to unsymmetrical flatfish. No data exist on role of miRNAs in halibut metamorphosis. Results miRNA profiling using SOLiD deep sequencing technology revealed a total of 199 conserved, one novel antisense, and one miRNA* mature form. Digital expression profiles of selected miRNAs were validated using reverse transcription quantitative PCR. We found developmental transition-specific miRNA expression. Expression of some miRNA* exceeded the guide strand miRNA. We revealed that nucleotide truncations and/or additions at the 3' end of mature miRNAs resulted in size variants showing differential expression patterns during the development in a number of miRNA families. We confirmed the presence of isomiRs by cloning and Sanger sequencing. Also, we found inverse relationship between expression levels of sense/antisense miRNAs during halibut development. Conclusion Developmental transitions during early development of Atlantic halibut are associated with expression of certain miRNA types. IsomiRs are abundant and often show differential expression during the development.

  14. Oral health in institucionalizated elderly patients in two care centers in Passo Fundo - RS

    Nicolau Silveira Neto; João Paulo de Carli; Maria Salete Sandini Linden; Micheline Sandini Trentin; Soluete Oliveira da Silva; Luciele Raquel Luft

    2008-01-01

    Objective: Considering that oral health, as well as general health are fundamental for maintaining the quality of life, the objective of this study was to investigate the oral health of the elderly population in the São José and Nossa Senhora da Luz Care Centers in Passo Fundo/ RS, Brazil. Methods: a clinical examination was performed in 107 elderly patients, to evaluate the oral health status as regards periodontal disease, edentulism, physiological alterations, and mucosa infection by the C...

  15. Design of a general purpose (RS-232C) analog-to-digital data converter

    The purpose of this project is to design a general purpose hardware that interfaces analog devices with any desirable computer supporting the RS-232 interface. The hardware incorporates bidirectional data transmission at 1,200 bps, 2,400 bps, 4800 bps, 9,600 bps, 19,200 pbs and 38400 bps. The communication / processing software has been written in C language that incorporates the idea of the potability of the software from one environment to the other. (author)

  16. EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity

    BESSEMS JOSEPH; Coecke, Sandra; GOULIARMOU VARVARA; Whelan, Maurice; Worth, Andrew

    2015-01-01

    Information on human toxicokinetics plays an important role in the safety assessment of chemicals, even though there are few data requirements in the EU regulatory framework. While existing EU test methods and OECD test guidelines are mostly based on animal procedures, there are increasing opportunities to achieve a 3Rs impact in this area by exploiting modern developments. For example, whole-body toxicokinetic information can be obtained by using physiologically-based toxicokinetic (PBTK) mo...

  17. Evaluation of two Vaisala RS92 radiosonde solar radiative dry bias correction algorithms

    Dzambo, Andrew M.; Turner, David D.; Mlawer, Eli J.

    2016-01-01

    Solar heating of the relative humidity (RH) probe on Vaisala RS92 radiosondes results in a large dry bias in the upper troposphere. Two different algorithms (Miloshevich et al., 2009, MILO hereafter; and Wang et al., 2013, WANG hereafter) have been designed to account for this solar radiative dry bias (SRDB). These corrections are markedly different with MILO adding up to 40 % more moisture to the original radiosonde profile than WANG; however, the impact of the two algo...

  18. Evaluation of two Vaisala RS92 radiosonde solar radiative dry bias correction algorithms

    A. M. Dzambo; D. D. Turner; E. J. Mlawer

    2015-01-01

    Solar heating of the relative humidity (RH) probe on Vaisala RS92 radiosondes results in a large dry bias in the upper troposphere. Two different algorithms (Miloshevich et al., 2009, MILO hereafter; and Wang et al., 2013, WANG hereafter) have been designed to account for this solar radiative dry bias (SRDB). These corrections are markedly different with MILO adding up to 40 % more moisture to the original radiosonde profile than WANG; however, the impact of the two algori...

  19. Bacillus anthracis HssRS signaling to HrtAB regulates heme resistance during infection

    Stauff, Devin L; Skaar, Eric P.

    2009-01-01

    Bacillus anthracis proliferates to high levels within vertebrate tissues during the pathogenesis of anthrax. This growth is facilitated by the acquisition of nutrient iron from host heme. However, heme acquisition can lead to the accumulation of toxic amounts of heme within B. anthracis. Here, we show that B. anthracis resists heme toxicity by sensing heme through the HssRS two-component system, which regulates expression of the heme-detoxifying transporter HrtAB. In addition, we demonstrate ...

  20. VHR Image Specifications for the CwRS Programme Campaign 2009

    AASTRAND Paer; ERLANDSSON Maria

    2009-01-01

    This document constitutes the specifications for VHR imagery to be used within the CwRS Programme. Its objective is to give the stakeholders in the image acquisition management chain clarity in the technical details of the process and describes the process flow starting from zone definition, through the image use, reaching image return and possible re-use of imagery at end of Campaign

  1. MODEL PENDIDIKAN MULTIKULTURAL RAMAH DI SEKOLAH ETHNO-RELIGIO SEGREGATION (E-RS) KOTA PONTIANAK

    Iwan Supardi; Sumarno Sumarno

    2014-01-01

    Penelitian ini bertujuan untuk memetakan pola dan mengukur intensitas hubungan antar-kelompok siswa etnis Melayu, Dayak, Tionghoa, dan Madura di empat sekolah swasta berbasis etno-religi (ethno-religio segregation/E-RS) di Kota Pontianak: SMA Sultan Syarif Abdurrahman (Melayu-Islam), SMA Yayasan Pendidikan Kristen (YPK)[Dayak-Nasrani], SMA Kristen Immanuel (Tionghoa-Nasrani, Konghucu, Budha), dan Madrasah Aliyah Swasta (MAS) Al-Anwar (Madura-Islam), berdasarkan sikap dan perilaku berprasangka...

  2. Experimental approach versus COSMO-RS assisted solvent screening for predicting the solubility of rapeseed oil

    Sicaire Anne-Gaëlle; Abert Vian Maryline; Fine Frédéric; Carré Patrick; Tostain Sylvain; Chemat Farid

    2015-01-01

    Vegetable oils take a large part in industry for food and non-food applications. However the extraction process of oil from oilseeds includes a solvent extraction step using hexane. Despite its various advantages it presents numerous drawbacks; it is sourced from petroleum, it has a high flammability and it appears to be dangerous for health and environment (CMR2). This study presents a theoretical screening using COSMO-RS simulations ...

  3. Hubble Space Telescope Imaging of the Expanding Nebular Remnant of the 2006 Outburst of RS Ophiuchi

    Harman, D J; Darnley, M J; O'Brien, T J; Bond, H E; Starrfield, S; Evans, A; Eyres, S P S; Ribeiro, V A R M; Echevarria, J M

    2008-01-01

    We report {\\it Hubble Space Telescope} imaging obtained 155 days and 449 days after the 2006 outburst of RS Ophiuchi. Both epochs show evidence of extended emission, consistent with that seen in earlier radio observations, and a maximum expansion rate of $3200\\pm300$ km s$^{-1}$ (in the plane of the sky). The extended structure is consistent with the remnant having a bipolar morphology with an inclination similar to that determined for the binary.

  4. Injury risk prediction for traffic accidents in Porto Alegre/RS, Brazil

    Perone, Christian S.

    2015-01-01

    This study describes the experimental application of Machine Learning techniques to build prediction models that can assess the injury risk associated with traffic accidents. This work uses an freely available data set of traffic accident records that took place in the city of Porto Alegre/RS (Brazil) during the year of 2013. This study also provides an analysis of the most important attributes of a traffic accident that could produce an outcome of injury to the people involved in the accident.

  5. ROBOTIC FORK-LIFT AUTOMATED STORAGE AND RETRIEVAL SYSTEM (AS/RS)

    S.U.CHAKOLE; G.H. WAGHMARE

    2013-01-01

    The automated storage and retrieval systems (AS/RS) are major material handling support systems that are commonly used in the automated factories, distribution centers, warehousing, and non manufacturing environments. Their applications vary widely from a simple storage and retrieval system for small parts to central systems where production, assembly, and manufacturing operations are concentrically located around them. This paper summarizes the literature study of a Robotic automated storage...

  6. Analysis on Ecological Sensitivity in Jinjie Mining Area Based on RS and GIS

    2011-01-01

    [Objective] The aim was to study ecological sensitivity in Jinjie mining area. [Method] Taking Jinjie mining area as study object, based on RS and GIS technology, ecological sensitivity in Jinjie mining area was assessed comprehensively from the aspects of soil erosion, desertification and geological disaster by means of multivariate weighted stack method. [Result] Most of Jinjie mining area belonged to extremely high sensitive or high sensitive area which accounted for 73.35% of total area, with little mod...

  7. Effect of Bcl-2 rs956572 Polymorphism on Age-Related Gray Matter Volume Changes

    Liu, Mu-En; Huang, Chu-Chung; Yang, Albert C.; Tu, Pei-Chi; Yeh, Heng-Liang; Hong, Chen-Jee; Chen, Jin-Fan; Liou, Ying-Jay; Lin, Ching-Po; Tsai, Shih-Jen

    2013-01-01

    The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM) volume across the adult lifespan. Our sample comprised 330 healthy volunteers ...

  8. Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study

    Xian-Yong Ma

    2012-01-01

    Full Text Available Brain-derived neurotrophic factor (BDNF has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265 in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242 with the GG genotype had higher BMI (P=0.009, waist circumference (P=0.002, hip (P=0.002, and weight (P=0.03 than GA or AA carriers (n=94. They had twice the risk of being overweight (BMI≥25 relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, and P=0.043. Interactions between rs6265 and polyunsaturated fatty acids (PUFA intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n=595 with the GG genotype had significantly lower BMI (P=0.009, hip (P=0.029, and weight (P=0.027 than GA or AA carriers (n=216. Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, and P=0.024. In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.

  9. Influence of p53 (rs1625895) polymorphism in kidney transplant recipients

    Negar Azarpira; Koorosh Kazemi; Masumeh Darai

    2014-01-01

    Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restricti...

  10. Coastal geomorphology and land use changes along coastal parts of Goa: An RS-GIS approach

    Samanta, S.; Kunte, P.D.; Mahender, K.

                Proceeding of GSDI 13; 2012; ID-106, 30 pp Proceedings of Global Geospatial Conference 2012 Québec City, Canada, 14-17 May 2012 Coastal Geomorphology and Landuse Changes along Coastal parts of Goa: An RS-GIS Approach S. Samanta 1 , Pravin D... Conference 2012 Québec City, Canada, 14-17 May 2012 ...

  11. Rotational modulation and flares on RS Canum Venaticorum and BY Draconis stars. 18: Coordinated VLA, ROSAT, and IUE observations of RS CVn binaries

    Fox, David C.; Linsky, Jeffrey L.; Veale, Anthony; Dempsey, Robert C.; Brown, Alex; Neff, James E.; Pagano, Isabella; Rodono, Marcello; Bromage, Gordon E.; Kuerster, Martin

    1994-01-01

    As part of a coordinated program of multi-wavelength observations of RS CVn close binary systems, we observed 15 systems with the Very Large Array (VLA) and 10 systems with IUE, simultaneously or nearly simultaneously with the ROSAT All Sky Survey observations of these stars. Of the 22 systems observed with ROSAT, three were observed both by IUE and the VLA. Radio observations were made at 3.6, 6 and 20 cm. Of the 15 observed RS CVn systems, we detected 11 with greater than 4 sigma confidence at one or more wavelengths. The IUE observations were made within the RIASS (ROSAT-IUE All Sky Survey) program. We present the results of the VLA observations, along with the corresponding subsets of the ROSAT Position Sensitive Proportional Counter (PSPC) X-ray and Wide Field Camera (WFC) XUV survey, and RIASS IUE observations. We obtained an extended VLA/IUE/ROSAT simultaneous coverage of one system, TY Pyx, covering more than one orbital period. These observations reveal that the quiescent radio flux of TY Pyx is relatively constant over time scales of up to 7 hours, but that it did change by a factor of 3 over 24 hours, probably due to a flare on 1990 Nov. 12. The UV, XUV and X-ray fluxes do not show large day-to-day or phase-related variability. The observation of the decay phase of a radio flare on EI Eri, with no accompanying X-ray or XUV flare, suggests that the lack of a strong correlation between X-ray and radio flares previously noted for dMe flare stars holds for RS CVn systems as well. We suggest that the radio flare may have been due to a coherent emission process such as electron cyclotron emission. The simultaneous measurements presented here provide a unique test of the general correlation between radio and soft X-ray luminosities, L(sub radio) approximately L(sub x exp m) (Drake et al. 1989) with a power-law slope close to unity, which was previously derived using data obtained years apart. Our derived slopes are consistent with and thus support the general

  12. μ-XRF/μ-RS vs. SR μ-XRD for pigment identification in illuminated manuscripts

    For the non-destructive identification of pigments and colorants in works of art, in archaeological and in forensic materials, a wide range of analytical techniques can be used. Bearing in mind that every method holds particular limitations, two complementary spectroscopic techniques, namely confocal μ-Raman spectroscopy (μ-RS) and μ-X-ray fluorescence spectroscopy (μ-XRF), were joined in one instrument. The combined μ-XRF and μ-RS device, called PRAXIS unites both complementary techniques in one mobile setup, which allows μ- and in situ analysis. μ-XRF allows one to collect elemental and spatially-resolved information in a non-destructive way on major and minor constituents of a variety of materials. However, the main disadvantages of μ-XRF are the penetration depth of the X-rays and the fact that only elements and not specific molecular combinations of elements can be detected. As a result μ-XRF is often not specific enough to identify the pigments within complex mixtures. Confocal Raman microscopy (μ-RS) can offer a surplus as molecular information can be obtained from single pigment grains. However, in some cases the presence of a strong fluorescence background limits the applicability. In this paper, the concrete analytical possibilities of the combined PRAXIS device are evaluated by comparing the results on an illuminated sheet of parchment with the analytical information supplied by synchrotron radiation μ-X-ray diffraction (SR μ-XRD), a highly specific technique. (orig.)

  13. R102W mutation in the RS1 gene responsible for retinoschisis and recurrent glaucoma

    Xiu-Feng Huang

    2014-02-01

    Full Text Available AIM: To identify the mutations in RS1 gene associated with typical phenotype of X-linked juvenile retinoschisis (XLRS and a rare condition of concomitant glaucoma.METHODS: Complete ophthalmic examinations were performed in the proband. The coding regions of the RS1 gene that encode retinoschisin were amplified by polymerase chain reaction and directly sequenced.RESULTS: The proband showed a typical phenotype of XLRS with large peripheral retinal schisis in both eyes, involving the macula and combined with foveal cystic change, reducing visual acuity. A typical phenotype of recurrent glaucoma with high intraocular pressure (IOP and reduced visual field was also demonstrated with the patient. Mutation analysis of RS1 gene revealed R102W (c.304C>T mutations in the affected male, and his mother was proved to be a carrier with the causative mutation and another synonymous polymorphism (c.576C>CT.CONCLUSION: We identified the genetic variations of a Chinese family with typical phenotype of XLRS and glaucoma. The severe XLRS phenotypes associated with R102W mutations reveal that the mutation determines a notable alteration in the function of the retinoschisin protein. Identification of the disease-causing mutation is beneficial for future clinical references.

  14. Flavour physics of the RS model with KK masses reachable at LHC

    The version of the higher-dimensional Randall-Sundrum (RS) model with matter in the bulk, which addresses the gauge hierarchy problem, has additional attractive features. In particular, it provides an intrinsic geometrical mechanism that can explain the origin of the large mass hierarchies among the Standard Model fermions. Within this context, a good solution for the gauge hierarchy problem corresponds to low masses for the Kaluza-Klein (KK) excitations of the gauge bosons. Some scenarios have been proposed in order to render these low masses (down to a few TeV) consistent with precision electroweak measurements. Here, we give specific and complete realizations of this RS version with small KK masses, down to 1 TeV, which are consistent with the entire structure of the fermions in flavour space: (1) all the last experimental data on quark/lepton masses and mixing angles (including massive neutrinos of Dirac type) are reproduced (2) flavour changing neutral current constraints are satisfied and (3) the effective suppression scales of non-renormalizable interactions (in the physical basis) are within the bounds set by low energy flavour phenomenology. Our result, on the possibility of having KK gauge boson modes as light as a few TeV, constitutes one of the first theoretical motivations for experimental searches of direct signatures at the LHC collider, of this interesting version of the RS model which accommodates fermion masses

  15. An X-ray-emitting blast wave from the recurrent nova RS Ophiuchi.

    Sokoloski, J L; Luna, G J M; Mukai, K; Kenyon, Scott J

    2006-07-20

    Stellar explosions such as novae and supernovae produce most of the heavy elements in the Universe. The onset of a nova is well understood as driven by runaway thermonuclear fusion reactions on the surface of a white dwarf in a binary star system; but the structure, dynamics and mass of the ejecta are not well known. In rare cases, the white dwarf is embedded in the wind nebula of a red-giant companion, and the explosion products plough through the nebula and produce X-ray emission. Here we report X-ray observations of such an event, from the eruption of the recurrent nova RS Ophiuchi. The hard X-ray emission from RS Ophiuchi early in the eruption emanates from behind a blast wave, or outward-moving shock wave, that expanded freely for less than 2 days and then decelerated owing to interaction with the nebula. The X-rays faded rapidly, suggesting that the blast wave deviates from the standard spherical shell structure. The early onset of deceleration indicates that the ejected shell had a low mass, the white dwarf has a high mass, and that RS Ophiuchi is therefore a progenitor of the type of supernova (type Ia) integral to studies of the expansion of the Universe. PMID:16855584

  16. Hazard degree identification of goafs based on scale effect of structure by RS-TOPSIS method

    胡建华; 甯榆林; 尚俊龙; 刘浪; 周科平; 陈宜楷

    2015-01-01

    In order to precisely predict the hazard degree of goaf (HDG), the RS-TOPSIS model was built based on the results of expert investigation. To evaluate the HDG in the underground mine, five structure size factors, i.e. goaf span, exposed area, goaf height, goaf depth, and pillar width, were selected as the evaluation indexes. And based on rough dependability in rough set (RS) theory, the weights of evaluation indexes were identified by calculating rough dependability between evaluation indexes and evaluation results. Fourty goafs in some mines of western China, whose indexes parameters were measured by cavity monitoring system (CMS), were taken as evaluation objects. In addition, the characteristic parameters of five grades’ typical goafs were built according to the interval limits value of single index evaluation. Then, using the technique for order preference by similarity to ideal solution (TOPSIS), five-category classification of HDG was realized based on closeness degree, and the HDG was also identified. Results show that the five-category identification of mine goafs could be realized by RS-TOPSIS method, based on the structure-scale-effect. The classification results are consistent with those of numerical simulation based on stress and displacement, while the coincidence rate is up to 92.5%. Furthermore, the results are more conservative to safety evaluation than numerical simulation, thus demonstrating that the proposed method is more easier, reasonable and more definite for HDG identification.

  17. PREPARATION AND CELL COMPATIBILITY OF FUNCTIONALIZED BIODEGRADABLE POLY(DL-LACTIDE-CO-RS-Β-MALIC ACID)

    Kui-lin Lai; Bin He; Zhong-wei Gu

    2008-01-01

    In order to create a functionalized biodegradable polymer for vascular tissue engineering application, poly(DL-lactide-co-RS-β-malic acid) (PDLLMAc) was synthesized. PDLLMAc was obtained after hydrogenolysis of poly(DL-lactide-co-RS-β-benzyl malolactonate) (PDLLMA), which was from the ring-opening polymerization of DL-lactide (DLLA)and RS-β-benzyl malolactonate (MA) using stannous octoate as catalyst. The copolymers were characterized by 1H-NMR,FTIR, GPC and DSC. The tensile strength and water uptake of the copolymers were measured. In copolymerization, theproportion of MA in the derived copolymers was lower than that in the feeding dose, a consequence of its lower reactivity.The molecular weight of the copolymers decreased with increasing MA content. The protective benzyl groups werecompletely removed in hydrogenolysis. The glass transition temperature (Tg) of the protected copolymers decreased withincreasing MA content. The mechanical strength test showed that the tensile strength of PDLLMA decreased whileelongation increased with MA content increasing, and the tensile strength increased and elongation decreased with increasingmalic acid content in PDLLMAc for the formation of hydrogen bonding. The water uptake showed that more hydrophilicmalic acid adsorbed more water in PDLLMAc. In order to test the reactivity of functional pendant groups, bioactive RGDpeptide was immobilized on the functionalized polymer film surface and smooth muscle cells (SMCs) were cultured on it.The results showed that the functionalized copolymer was biocompatible and could be potentially applied in vascular tissueengineering.

  18. (R,S)-2-chlorophenoxyl pyrazolides as novel substrates for improving lipase-catalyzed hydrolytic resolution.

    Kao, Min-fang; Lu, Pei-yu; Kao, Jou-yan; Wang, Pei-yun; Wu, An-chi; Tsai, Shau-Wei

    2012-01-01

    The best reaction condition of Candida antartica lipase B as biocatalyst, 3-(2-pyridyl)pyrazole as leaving azole, and water-saturated methyl t-butyl ether as reaction medium at 45°C were first selected for performing the hydrolytic resolution of (R,S)-2-(4-chlorophenoxyl) azolides (1-4). In comparison with the kinetic resolution of (R,S)-2-phenylpropionyl 3-(2-pyridyl)pyrazolide or (R,S)-α-methoxyphenylacetyl 3-(2-pyridyl)pyrazolide at the same reaction condition, excellent enantioselectivity with more than two order-of-magnitudes higher activity for each enantiomer was obtained. The resolution was then extended to other (R,S)-3-(2-pyridyl)pyrazolides (5-7) containing 2-chloro, 3-chloro, or 2,4-dichloro substituent, giving good (E > 48) to excellent (E > 100) enantioselectivity. The thermodynamic analysis for 1, 2, and 4-7 demonstrates profound effects of the acyl or leaving moiety on varying enthalpic and entropic contributions to the difference of Gibbs free energies. A thorough kinetic analysis further indicates that on the basis of 6, the excellent enantiomeric ratio for 4 and 7 is due to the higher reactivity of (S)-4 and lower reactivity of (R)-7, respectively. PMID:22012845

  19. {mu}-XRF/{mu}-RS vs. SR {mu}-XRD for pigment identification in illuminated manuscripts

    Snickt, G. van der; Nolf, W. de; Vekemans, B.; Janssens, K. [University of Antwerp, Department of Chemistry, Antwerp (Belgium)

    2008-07-15

    For the non-destructive identification of pigments and colorants in works of art, in archaeological and in forensic materials, a wide range of analytical techniques can be used. Bearing in mind that every method holds particular limitations, two complementary spectroscopic techniques, namely confocal {mu}-Raman spectroscopy ({mu}-RS) and {mu}-X-ray fluorescence spectroscopy ({mu}-XRF), were joined in one instrument. The combined {mu}-XRF and {mu}-RS device, called PRAXIS unites both complementary techniques in one mobile setup, which allows {mu}- and in situ analysis. {mu}-XRF allows one to collect elemental and spatially-resolved information in a non-destructive way on major and minor constituents of a variety of materials. However, the main disadvantages of {mu}-XRF are the penetration depth of the X-rays and the fact that only elements and not specific molecular combinations of elements can be detected. As a result {mu}-XRF is often not specific enough to identify the pigments within complex mixtures. Confocal Raman microscopy ({mu}-RS) can offer a surplus as molecular information can be obtained from single pigment grains. However, in some cases the presence of a strong fluorescence background limits the applicability. In this paper, the concrete analytical possibilities of the combined PRAXIS device are evaluated by comparing the results on an illuminated sheet of parchment with the analytical information supplied by synchrotron radiation {mu}-X-ray diffraction (SR {mu}-XRD), a highly specific technique. (orig.)

  20. Association of Calcium-Sensing Receptor (CASR rs 1801725 with Colorectal Cancer

    Fateme Rostami

    2012-07-01

    Full Text Available Background: Calcium induces apoptosis in intestinal epithelial cells and subsequently prevents colorectal cancer through ion calcium receptor. Calcium-sensing receptor mutation reduces the expression of this receptor, and subsequently in reduces calcium transportation. Many studies have shown that Calcium-sensing receptor gene polymorphism may increase the risk of colorectal cancer. The purpose of this study is to assess the prevalence of calcium-sensing receptor polymorphisms (rs 1801725 in Iran society and to examine the role of this polymorphism in the increased risk of colorectal cancer (CRC.Materials and Methods: The research was a case-control study. 105 patients with colorectal cancer and 105 controls were randomly studied using polymerase chain reaction and restriction fragment length polymorphism. χ2 test and software 16- SPSS were used for statistical analysis.Results: In patient samples, the frequency of the genotypes TT, GT, GG in gene CASR rs 1801725 was respectively 64.8, 32.4, and 2.9 and the frequency of this polymorphism in control samples was respectively 51.2, 45.7, and 2.9. Frequency of allele G in patient samples was 0/48 and frequency of allele T was 0.25. In addition, Frequency of allele G in control samples was 0.74 and Frequency of allele T was calculated 0.19.Conclusion: The results show that calcium-sensing receptor variant (1801725 rs is not associated with increased risk of colorectal cancer.

  1. Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer.

    Pan, W; Liao, H

    2015-01-01

    The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, and WanFang Data. The literature was screened based on inclusion and exclusion criteria. A meta-analysis was performed by calculating the combined odds ratios (OR) and 95% confidence intervals (CI) using the RevMan 5.0. A total of 7 case-control studies were selected, which included 1439 cases and 2927 control subjects. Meta-analysis showed that the rs4680 polymorphism was not associated with ovarian cancer [GG vs (GA+AA): OR = 1.02, 95%CI = 0.88-1.19; G vs A allele: OR = 1.0, 95%CI = 0.90-1.11]. We, therefore, conclude that the COMT rs4680 polymorphism is not associated with susceptibility to ovarian cancer. PMID:26681027

  2. The effect of observing session duration on OPUS-RS results

    Dincer Dogru, A.; Ugur Sanli, D.; Hayal, Adem G.; Berber, Mustafa

    2016-04-01

    Online GPS positioning software has now a widespread interest among practitioners and researchers. Researchers rescently use online software to monitor natural hazards such as landslides. The fact that this software usually employs continuously operating GPS stations of the International GNSS Service (IGS) as reference stations in the processing, the community of world-wide users is growing day by day. In the monitoring of landslides, rapid static mode of a GPS surveying is usually preferred because it is possible to have wider field coverage with only a few minutes of data and low cost ground markers. Results comparable to static positioning can be obtained with careful network design and processing strategies. Some online software such as OPUS-RS developed by the National Geodetic Survey (NGS) of the USA provides rapid static positioning engine that processes GPS data from sessions of only a few minutes. 15-minute is the recommended/standard observing session duration for OPUS-RS processing. In this study, using the CORS data operating in the US, we carried out some tests in which the observing session duration is changed from 8 through 118 minutes, and observed the accuracy change on the OPUS-RS solutions. Then we compared the results with the accuracy levels given for 15-min solutions by the NGS. We determined that there is the effect of changing observing session duration on the obtained results, and we report them in this study.

  3. ANIMAL WELFARE FROM MOUSE TO MOOSE--IMPLEMENTING THE PRINCIPLES OF THE 3RS IN WILDLIFE RESEARCH.

    Lindsjö, Johan; Fahlman, Åsa; Törnqvist, Elin

    2016-04-01

    The concept of the 3Rs (replacement, reduction, and refinement) was originally developed for improving laboratory animal welfare and is well known in biomedical and toxicologic research. The 3Rs have so far gained little attention in wildlife research, and there could be several reasons for this. First, researchers may prioritize the welfare of populations and ecosystems over the welfare of individual animals. The effects of research on individual animals can, however, impact welfare and research quality at group and population levels. Second, researchers may find it difficult to apply the 3Rs to studies of free-living wildlife because of the differences between laboratory and wild animals, species, research environment, and purpose and design of the studies. There are, however, several areas where it is possible to transfer the 3R principles to wildlife research, including replacement with noninvasive research techniques, reduction with optimized experimental design, and refinement with better methods of capture, anesthesia, and handling. Third, researchers may not have been trained in applying the 3Rs in wildlife research. This training is needed since ethics committees, employers, journal publishers, and funding agencies increasingly require researchers to consider the welfare implications of their research. In this paper, we compare the principles of the 3Rs in various research areas to better understand the possibilities and challenges of the 3Rs in wildlife research. We emphasize the importance of applying the 3Rs systematically throughout the research process. Based on experiences from laboratory research, we suggest three key factors to enhance implementation of the 3Rs in wildlife research: 1) organizational structure and management, 2) 3R awareness, and 3) research innovation, validation, and implementation. Finally, we encourage an interdisciplinary approach to incorporate the 3R principles in wildlife research. For improved animal welfare and increased

  4. Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

    Martin Heni

    Full Text Available OBJECTIVE: Polypyrimidine tract-binding protein 1 (PTBP1 promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a role in β-cells function. We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or proinsulin conversion. METHODS: We genotyped 1,502 healthy German subjects for four tagging single nucleotide polymorphisms (SNPs within the PTBP1 locus (rs351974, rs11085226, rs736926, and rs123698 covering 100% of genetic variation with an r(2≥0.8. The subjects were metabolically characterized by an oral glucose tolerance test with insulin, proinsulin, and C-peptide measurements. A subgroup of 320 subjects also underwent an IVGTT. RESULTS: PTBP1 SNP rs11085226 was nominally associated with lower insulinogenic index and lower cleared insulin response in the OGTT (p≤0.04. The other tested SNPs did not show any association with the analyzed OGTT-derived secretion parameters. In the IVGTT subgroup, SNP rs11085226 was accordingly associated with lower insulin levels within the first ten minutes following glucose injection (p = 0.0103. Furthermore, SNP rs351974 was associated with insulin levels in the IVGTT (p = 0.0108. Upon interrogation of MAGIC HOMA-B data, our rs11085226 result was replicated (MAGIC p = 0.018, but the rs351974 was not. CONCLUSIONS: We conclude that common genetic variation in PTBP1 influences glucose-stimulated insulin secretion. This underlines the importance of PTBP1 for beta cell function in vivo.

  5. Controle da qualidade das sementes de arroz irrigado utilizadas em Santa Maria/RS Control of quality of the flooded rice seeds in Santa Maria/RS

    Enio Marchezan; Nilson Lemos de Menezes; Carla do Amaral Siqueira

    2001-01-01

    Este trabalho foi desenvolvido com o objetivo de caracterizar e classificar a qualidade física, fisiológica e sanitária das sementes de arroz irrigado utilizadas por produtores de Santa Maria/RS, Brasil. Foram coletadas 117 amostras de sementes de produtores da região, no ano agrícola de 1997/98, nas quais se determinaram umidade, presença de grãos de arroz vermelho, presença de fungos e nematóides, germinação e vigor. As sementes apresentaram qualidade fisiológica e sanitária de média a boa,...

  6. Comportamento fenológico e produtivo de marmeleiros em Veranópolis, RS Vegetative and productive behavior of quinces in Veranópolis, RS, Brazil

    João Caetano Fioravanço; Paulo Roberto Simonetto; Etmar Osmar Grellmann

    2006-01-01

    Com este trabalho, avalia-se o comportamento de nove cultivares de marmeleiro (Cydonia oblonga Miller) cultivadas em Veranópolis, RS, em relação à época de floração (início e final) e maturação (início e final), massa média dos frutos, produção por planta (peso e número de frutos) e produtividade por hectare. A coleção, constituída de três plantas por cultivar, foi implantada em 1995, no espaçamento de 5,0 m x 3,0 m (667 plantas/ha). As plantas foram conduzidas no sistema de líder central. Os...

  7. A Design of SSI-RS485 Converter%一种SSI转RS485转换器的设计

    张博; 曹世康

    2010-01-01

    设计了一种基于单片机ATtiny2313的协议转换器. 转换器的主要任务是将系统中多圈绝对式旋转编码器SSI(同步串行接口)协议转换为车载控制器的RS485协议. 针对复杂的车载系统,给出了若干转换器的抗干扰措施. 实践证明:所设计的转换器结构简单、运行可靠、抗干扰能力强,能实现SSI接口的传输速度快、连线简单、抗干扰能力强的优点,便于与车载控制系统的集成.

  8. Preliminary evidence for cue-induced alcohol craving modulated by serotonin transporter gene polymorphism rs1042173

    Nassima eAit-Daoud

    2012-02-01

    Full Text Available We previously have shown that cue-induced alcohol craving and propensity for higher drinking are modulated by allelic differences in SLC6A4. In an independent study, we characterized a functional polymorphism, rs1042173 (G/T, in the SLC6A4 3′-untranslated region (3′-UTR; the T allele was associated with lower mRNA and protein levels, and the alcohol-dependent (AD individuals carrying the TT genotype showed higher drinking intensity compared with G-allele carriers. Building upon these findings, we hypothesized that the low-expressing TT genotype associated with intense drinking would predict higher craving for alcohol in AD individuals. In this pilot study, we sought to test our hypothesis by examining 34 Hispanic AD volunteers (mean age, 34.8 years for rs1042173 genotype-based (i.e., TT vs. TG/GG (Gx differences in subjective response to alcohol. We employed a human laboratory paradigm and analyzed the data using a linear mixed-effects model to assess treatment, cue procedures, and genotype main effects as well as the two-way interaction effects between them. On subjective urge to drink and crave for a drink, we found a significant main effect of the cue experiment (p ≤ 0.01 and an interaction effect between genotype and cue effects (p < 0.05. TT genotype was associated with higher intensity of drinking and craving for alcohol. Our results not only support the hypothesis that rs1042173 is a genetic marker for cue-induced alcohol craving among AD males but also are suggestive of a neurobiological mechanism associated with the rs1042173-TT genotype that triggers a disproportionate craving in response to alcohol consumption, which in turn may lead to more intense drinking. Future studies with larger sample sizes are needed to characterize the interactive effects of the serotonin transporter-linked polymorphic region (5′-HTTLPR-L-allele reported in our previous study and of the rs1042173-TT genotype on cue-induced alcohol craving.

  9. Reference quality upper-air measurements: GRUAN data processing for the Vaisala RS92 radiosonde

    R. J. Dirksen

    2014-12-01

    Full Text Available The GCOS (Global Climate Observing System Reference Upper-Air Network (GRUAN data processing for the Vaisala RS92 radiosonde was developed to meet the criteria for reference measurements. These criteria stipulate the collection of metadata, the use of well-documented correction algorithms, and estimates of the measurement uncertainty. An important and novel aspect of the GRUAN processing is that the uncertainty estimates are vertically resolved. This paper describes the algorithms that are applied in version 2 of the GRUAN processing to correct for systematic errors in radiosonde measurements of pressure, temperature, humidity, and wind, as well as how the uncertainties related to these error sources are derived. Currently, the RS92 is launched on a regular basis at 13 out of 15 GRUAN sites. An additional GRUAN requirement for performing reference measurements with the RS92 is that the manufacturer-prescribed procedure for the radiosonde's preparation, i.e. heated reconditioning of the sensors and recalibration during ground check, is followed. In the GRUAN processing however, the recalibration of the humidity sensors that is applied during ground check is removed. For the dominant error source, solar radiation, laboratory experiments were performed to investigate and model its effect on the RS92's temperature and humidity measurements. GRUAN uncertainty estimates are 0.15 K for night-time temperature measurements and approximately 0.6 K at 25 km during daytime. The other uncertainty estimates are up to 6% relative humidity for humidity, 10–50 m for geopotential height, 0.6 hPa for pressure, 0.4–1 m s−1 for wind speed, and 1° for wind direction. Daytime temperature profiles for GRUAN and Vaisala processing are comparable and consistent within the estimated uncertainty. GRUAN daytime humidity profiles are up to 15% moister than Vaisala processed profiles, of which two-thirds is due to the radiation dry bias correction and one-third is due

  10. Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.

    Tran-Winkler, Hien J; Love, John F; Gryllos, Ioannis; Wessels, Michael R

    2011-10-01

    The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A Streptococcus (GAS). While some studies have suggested that the sensor histidine kinase CsrS responds to membrane perturbations as a result of various environmental stresses, other data have implicated the human antimicrobial peptide LL-37 and extracellular Mg(2+) as specific signals. We now report that Mg(2+) and LL-37 have opposite effects on expression of multiple genes that are activated or repressed by the transcriptional regulator CsrR. Using a GAS isolate representative of the recently emerged and widely disseminated M1T1 clone implicated in severe invasive disease, we found marked up-regulation by CsrRS of multiple virulence factors including pyrogenic exotoxin A, DNase Sda1, streptolysin O, and the hyaluronic acid capsular polysaccharide, among others. Topology and surface protein labeling studies indicated that CsrS is associated with the bacterial cell membrane and has a surface-exposed extracellular domain accessible to environmental ligands. Replacement of a cluster of three acidic amino acids with uncharged residues in the extracellular domain of CsrS abrogated LL-37 signaling and conferred a hyporesponsive phenotype consistent with tonic activation of CsrS autokinase activity, an effect that could be overridden by mutation of the CsrS active site histidine. Both loss- and gain-of-function mutations of a conserved site in the receiver domain of CsrR established an essential role for lysine 102 in CsrS-to-CsrR signal transduction. These results provide strong evidence that Mg(2+) and LL-37 are specific signals that function by altering CsrS autokinase activity and downstream phosphotransfer to CsrR to modulate its activity as a transcriptional regulator. The representation of multiple antiphagocytic and cytotoxic factors in the CsrRS regulon together with results of in vitro phagocytic killing assays support the hypothesis that CsrRS mediates conversion

  11. RS-SNP: a random-set method for genome-wide association studies

    Mukherjee Sayan

    2011-03-01

    Full Text Available Abstract Background The typical objective of Genome-wide association (GWA studies is to identify single-nucleotide polymorphisms (SNPs and corresponding genes with the strongest evidence of association (the 'most-significant SNPs/genes' approach. Borrowing ideas from micro-array data analysis, we propose a new method, named RS-SNP, for detecting sets of genes enriched in SNPs moderately associated to the phenotype. RS-SNP assesses whether the number of significant SNPs, with p-value P ≤ α, belonging to a given SNP set is statistically significant. The rationale of proposed method is that two kinds of null hypotheses are taken into account simultaneously. In the first null model the genotype and the phenotype are assumed to be independent random variables and the null distribution is the probability of the number of significant SNPs in greater than observed by chance. The second null model assumes the number of significant SNPs in depends on the size of and not on the identity of the SNPs in . Statistical significance is assessed using non-parametric permutation tests. Results We applied RS-SNP to the Crohn's disease (CD data set collected by the Wellcome Trust Case Control Consortium (WTCCC and compared the results with GENGEN, an approach recently proposed in literature. The enrichment analysis using RS-SNP and the set of pathways contained in the MSigDB C2 CP pathway collection highlighted 86 pathways rich in SNPs weakly associated to CD. Of these, 47 were also indicated to be significant by GENGEN. Similar results were obtained using the MSigDB C5 pathway collection. Many of the pathways found to be enriched by RS-SNP have a well-known connection to CD and often with inflammatory diseases. Conclusions The proposed method is a valuable alternative to other techniques for enrichment analysis of SNP sets. It is well founded from a theoretical and statistical perspective. Moreover, the experimental comparison with GENGEN highlights that it is

  12. Controle da qualidade das sementes de arroz irrigado utilizadas em Santa Maria/RS Control of quality of the flooded rice seeds in Santa Maria/RS

    Enio Marchezan

    2001-06-01

    Full Text Available Este trabalho foi desenvolvido com o objetivo de caracterizar e classificar a qualidade física, fisiológica e sanitária das sementes de arroz irrigado utilizadas por produtores de Santa Maria/RS, Brasil. Foram coletadas 117 amostras de sementes de produtores da região, no ano agrícola de 1997/98, nas quais se determinaram umidade, presença de grãos de arroz vermelho, presença de fungos e nematóides, germinação e vigor. As sementes apresentaram qualidade fisiológica e sanitária de média a boa, contendo, no entanto, altos níveis de arroz vermelho, o que reduz a qualidade dos lotes e constitui-se no principal fator restritivo à obtenção de maiores rendimentos.This study was conducted in order to characterize and classify the physical, physiological and sanitary qualities of irrigated rice seeds used by rice farmers in Santa Maria (RS. A total of 117 seed samples were collected among farmers of this region during the 1997/98 growing season. Seed moisture, presense of red rice seeds, presense of fungy and nematodes, germination percentage and seed vigor were determined. In regard to physyological and sanitary quality the seed qualities varied between medium and good. However the presense of high levels of red rice seeds reduced the overall quality of the seeds and is the main factor that limits higher productivity grains.

  13. Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population

    López Valverde, Gloria; Garcia Martin, Elena; Larrosa Povés, José M.; Polo Llorens, Vicente; Pablo Júlvez, Luis E.

    2016-01-01

    Purpose To determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development. Methods We have performed a retrospective study over three groups of patients. The group with pre-senile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes. Results The comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0,05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0,05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0,031; OR = 1.04–15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056). Conclusions Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract. PMID:27248495

  14. Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi

    Liao, Xiwen; Han, Chuangye; Qin, Wei; Liu, Xiaoguang; Yu, Long; Lu, Sicong; Chen, Zhiwei; Zhu, Guangzhi; Su, Hao; Mo, Zengnan; Qin, Xue; Peng, Tao

    2016-01-01

    Objective: The genome-wide association approach was employed to explore the association between single nucleotide polymorphisms (SNPs) and TP53 expression in the HBV-related hepatocellular carcinoma (HCC) of Chinese patients in Guangxi. Methods: 403 HBV-related HCC patients were recruited into this study and classified according to the TP53 expression in the cancer by immunohistochemistry. DNA was extracted from the cancer and genotyped with the Human ExomeBeadChip 12v1-1 system; quality control and principal-component analysis (PCA) were applied for data analysis. Results: The Genome-wide association analysis indicated that rs2797992 with a P value of 4.35 × 10-5 locus in PLCE1 gene and rs6950826 with a P value of 2.2 × 10-3 locus in EGFR gene were associated with TP53 expression in the HCC. A allele of rs2797992 predicted a decreased risk for TP53 expression in HCC. In contrast, A allele of rs6950826 increased the risk for TP53 expression. There was no strong LD locus in the tested regions. PLCE1 and EGFR were associated with TP53 in pathway and at HCC mRNA level. Conclusion: rs2797992 of PLCE1 gene and rs6950826 of EGFR gene are associated with TP53 expression, but not with the prognosis of HBV-related HCC in HBV-related HCC of Chinese patients in Guangxi. PMID:27186304

  15. Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis.

    Lou, Qiang; Ma, Yuanfang; Qu, Di

    2016-04-01

    Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, the S. epidermidis SaeRS was identified to negatively regulate the expression of genes involved in competence (comF, murF), cytolysis (lrgA), and autolysis (lytS) by DNA microarray or real-time RT-PCR analysis. In addition, saeRS mutant showed increased competence and higher susceptibility to antibiotics such as penicillin and oxacillin than the wild-type strain. The study will be helpful for understanding the characterization of the SaeRS in S. epidermidis. PMID:26898187

  16. Developemnt of BAC resources for targeted analysis of the short arm of chromosome 1R (1RS)

    Kovářová, Pavlína; Šafář, Jan; Šimková, Hana; Suchánková, Pavla; Bartoš, Jan; Janda, Jaroslav; Doleželová, Marie; Čihalíková, Jarmila; Lelley, T.; Doležel, Jaroslav

    2006. p. 81. [2nd Congress of the International Cytogenetics and Genome Society. 25.06.2006-29.06.2006, University of Kent, Canterbury] Keywords : BAC library * rye * chromosome 1R (1RS) Subject RIV: EB - Genetics ; Molecular Biology

  17. Trails, RS2477, iron sgid, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'iron sgid'....

  18. Trails, RS2477, 3200 ev, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '3200 ev'....

  19. Trails, RS2477, d roads 053008, Published in 2008, 1:24000 (1in=2000ft) scale, Tooele County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'd roads...

  20. Trails, RS2477, add events rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add events...

  1. Trails, RS2477, b roads 053008, Published in 2008, 1:24000 (1in=2000ft) scale, Tooele County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'b roads...

  2. Trails, RS2477, 3200 rd, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '3200 rd'....

  3. Trails, RS2477, class b roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'class b...

  4. Trails, RS2477, cinter pit rd, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as 'cinter pit...

  5. Trails, RS2477, Juab claims f, Published in 2007, 1:24000 (1in=2000ft) scale, Juab County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2007. It is described as 'Juab claims...

  6. Trails, RS2477, class B, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as 'class B'....

  7. Trails, RS2477, cinter pit ev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'cinter pit...

  8. Trails, RS2477, iron rds, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'iron rds'....

  9. Trails, RS2477, Juab claims m, Published in 2007, 1:24000 (1in=2000ft) scale, Juab County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2007. It is described as 'Juab claims...

  10. Trails, RS2477, sb events, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'sb events'....

  11. Trails, RS2477, add roads, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'add roads'....

  12. Trails, RS2477, iron events 2, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'iron events...

  13. Trails, RS2477, add roads rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add roads...

  14. Trails, RS2477, 422004 rd NAD83, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as '422004 rd...

  15. 5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus.

    Kruschwitz, J D; Walter, M; Varikuti, D; Jensen, J; Plichta, M M; Haddad, L; Grimm, O; Mohnke, S; Pöhland, L; Schott, B; Wold, A; Mühleisen, T W; Heinz, A; Erk, S; Romanczuk-Seiferth, N; Witt, S H; Nöthen, M M; Rietschel, M; Meyer-Lindenberg, A; Walter, H

    2015-07-01

    The s/s-genotype of the 5-HTTLPR polymorphism and the personality trait of neuroticism have both been associated with experiences of negative affect, anxiety and mood disorders, as well as an emotional processing bias towards negative facial emotions. On a neural level, this bias can be characterized by altered amygdala and fusiform gyrus (FFG) activity during perception of negative facial expressions. Using resting-state functional magnetic resonance imaging in a multi-center-sample of 178 healthy subjects of European descent, this study investigated the association of 5-HTTLPR (short s- and long l-allele) including the genotype of the single nucleotide polymorphism (SNP) rs25531 (A/G) within this region polymorphism, and trait neuroticism on resting-state functional connectivity (rs-FC) between amygdala and the FFG. Moreover, we aimed to identify additional brain regions with associations of 5-HTTLPR/rs25531 (combined according to its expression; low: s/s; high: l(A)/l(A); intermediate: s/l(A), s/l(G), l(G)/l(G), l(A)/l(G)) and trait neuroticism to amygdala rs-FC. Separate analyses for 5-HTTLPR/rs25531 and neuroticism (controlling for age, gender, handedness, and research site) revealed that s/s-homozygotes and individuals high in neuroticism obtained altered amygdala rs-FC in the right occipital face area, which is considered to be a "core component" of the face processing system. Importantly, effects of neuroticism were replicated across three independent research sites. Additionally, associations of 5-HTTLPR/rs25531 genotype and amygdala rs-FC were observed in the anterior and posterior cingulate cortex, whereas neuroticism was not related to rs-FC in these areas. The presented data implies that 5-HTTLPR/rs25531 variants and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus and suggests that variants of 5-HTTLPR/rs25531 genotype and different levels of neuroticism may partly account for altered processing of

  16. A validation of the Experiences in Close Relationships-Relationship Structures scale (ECR-RS) in adolescents

    Donbaek, Dagmar Feddern; Elklit, Ask

    2014-01-01

    Emerging evidence points toward a two-dimensional attachment construct: avoidance and anxiety. The Experiences in Close Relationships-Relationship Structures scale (ECR-RS; Fraley, Heffernan, Vicary, & Brumbaugh, 2011) is a questionnaire assessing two-dimensional relationship-specific attachment......, exhibiting satisfactory construct validity, including factorspecific links to the model of adult attachment (Bartholomew & Horowitz, 1991), and independent factor discrimination between subgroups. A robust validation supports the application of the ECR-RS to assessing relationship-specific adolescent...

  17. Molecular Characterization and Expression Proifles of Myrosinase Gene (RsMyr2) in Radish (Raphanus sativus L.)

    PAN Yan; XU Yuan-yuan; ZHU Xian-wen; LIU Zhe; GONG Yi-qin; XU Liang; GONG Mao-yong; LIU Li-wang

    2014-01-01

    Myrosinase is a defense-related enzyme and is capable of hydrolyzing glucosinolates into a variety of compounds, some of which are toxic to pathogens and herbivores. Many studies revealed that a number of important vegetables or oil crops contain the myrosinase-glucosinolate system. However, the related promoter and genomic DNA sequences as well as expression proifles of myrosinase gene remain largely unexplored in radish (Raphanus sativus). In this study, the 2798 bp genomic DNA sequence, designated asRsMyr2, was isolated and analyzed in radish. TheRsMyr2 consisting of 12 exons and 11 introns relfected the common gene structure of myrosinases. Using the genomic DNA walking approach, the 5´-lfanking region upstream ofRsMyr2 with length of 1711 bp was successfully isolated. PLACE and PlantCARE analyses revealed that this upstream region could be the promoter ofRsMyr2,which contained several basiccis-regulatory elements including TATA-box, CAAT-box and regulatory motifs responsive to defense and stresses. Furthermore, recombinant pET-RsMyr2protein separated by SDS-PAGE was identiifed as myrosinase with mass spectrometry. Real-time PCR analysis showed differential expression proifles ofRsMyr2 in leaf, stem and root at different developmental stages (e.g., higher expression in leaf at cotyledon stage and lower in lfesh root at mature stage). Additionally, theRsMyr2geneexhibited up-regulated expression when treated with abscisic acid (ABA), methyl jasmonate (MeJA) and hydrogen peroxide (H2O2), whereas it was down-regulated by wounding (WO) treatment. The ifndings indicated that the expression ofRsMyr2 gene was differentially regulated by these stress treatments. These results could provide new insight into elucidating the molecular characterization and biological function of myrosinase in radish.

  18. Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia

    Liu, Mu-En; Huang, Chu-Chung; Hwang, Jen-Ping; Yang, Albert C.; Tu, Pei-Chi; Yeh, Heng-Liang; Hong, Chen-Jee; Liou, Ying-Jay; Chen, Jin-Fan; Lin, Ching-Po; Tsai, Shih-Jen

    2011-01-01

    The Bcl-2 gene is a major regulator of neural plasticity and cellular resilience. A single-nucleotide polymorphism (SNP) in the Bcl-2 gene, Bcl-2 rs956572, significantly modulates the expression of Bcl-2 protein and cellular vulnerability to apoptosis. This study investigated the association between the Bcl-2 rs956572 SNP and brain structural abnormalities in non-demented elders, and to test the relationship between neuropsychological performance and regional gray matter (GM) volumes. Our sam...

  19. ISOLATION, CHARACTERIZATION OF PHYTASE PRODUCING BACILLUS SUBTILS BtRS2 FROM THE RHIZOSPHERE SOIL OF Bt COTTON FIELD

    K. Usha Sri

    2013-01-01

    Soil samples of Bt Rhizosphere were collected from Bt cotton growing area of Andhra Pradesh, India and was used as a source material for isolation and screening of phytase producing bacteria. 19Bacteria were isolated from Bt Rhizosphere. Phytase enzyme activity of the cultures was screened on modified phytase solubulizing medium (MPSM). The result inferred that six isolates BtRS1 to BtRS6 were strongly positive in enzyme activity than six of other microorganisms while seven isolates were foun...

  20. Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.

    Dannlowski, U; Grabe, H J; Wittfeld, K; Klaus, J; Konrad, C; Grotegerd, D; Redlich, R; Suslow, T; Opel, N; Ohrmann, P; Bauer, J; Zwanzger, P; Laeger, I; Hohoff, C; Arolt, V; Heindel, W; Deppe, M; Domschke, K; Hegenscheid, K; Völzke, H; Stacey, D; Meyer Zu Schwabedissen, H; Kugel, H; Baune, B T

    2015-03-01

    In two large genome-wide association studies, an intergenic single-nucleotide polymorphism (SNP; rs7294919) involved in TESC gene regulation has been associated with hippocampus volume. Further characterization of neurobiological effects of the TESC gene is warranted using multimodal brain-wide structural and functional imaging. Voxel-based morphometry (VBM8) was used in two large, well-characterized samples of healthy individuals of West-European ancestry (Münster sample, N=503; SHIP-TREND, N=721) to analyze associations between rs7294919 and local gray matter volume. In subsamples, white matter fiber structure was investigated using diffusion tensor imaging (DTI) and limbic responsiveness was measured by means of functional magnetic resonance imaging (fMRI) during facial emotion processing (N=220 and N=264, respectively). Furthermore, gene x environment (G × E) interaction and gene x gene interaction with SNPs from genes previously found to be associated with hippocampal size (FKBP5, Reelin, IL-6, TNF-α, BDNF and 5-HTTLPR/rs25531) were explored. We demonstrated highly significant effects of rs7294919 on hippocampal gray matter volumes in both samples. In whole-brain analyses, no other brain areas except the hippocampal formation and adjacent temporal structures were associated with rs7294919. There were no genotype effects on DTI and fMRI results, including functional connectivity measures. No G × E interaction with childhood maltreatment was found in both samples. However, an interaction between rs7294919 and rs2299403 in the Reelin gene was found that withstood correction for multiple comparisons. We conclude that rs7294919 exerts highly robust and regionally specific effects on hippocampal gray matter structures, but not on other neuropsychiatrically relevant imaging markers. The biological interaction between TESC and RELN pointing to a neurodevelopmental origin of the observed findings warrants further mechanistic investigations. PMID:24776739

  1. Global and structured waves of rs-fMRI signal identified as putative propagation of spontaneous neural activity.

    Amemiya, Shiori; Takao, Hidemasa; Hanaoka, Shohei; Ohtomo, Kuni

    2016-06-01

    Conventional resting-state fMRI (rs-fMRI) studies have focused on investigating the synchronous neural activity in functionally relevant distant regions that are termed as resting-state networks. On the other hand, less is known about the spatiotemporal dynamics of the spontaneous activity of the brain. By examining the characteristics of both rs-fMRI and vascular time lag that was measured using dynamic susceptibility contrast-enhanced perfusion weighted imaging, the present study identifies several structured propagation of the rs-fMRI signal as putative neural streams. Temporal shift of both rs-fMRI and perfusion imaging data in each voxel compared with the averaged whole-brain signal was computed using cross-correlation analysis. In contrast to the uniformity of the vascular time lag across subjects, whole-brain rs-fMRI time lag was estimated to be composed of three independent components. After regression of vascular time lag, independent component analysis was applied to rs-fMRI data. The putative neural streams showed slow propagation of the signal from task-positive regions to main nodes of the default mode network, which may represent a mode of transmission underlying the interactions among the resting-state networks. PMID:27012499

  2. The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.

    Batista, Rui; Cruvinel-Carloni, Adriana; Vinagre, João; Peixoto, Joana; Catarino, Telmo A; Campanella, Nathalia Cristina; Menezes, Weder; Becker, Aline Paixão; de Almeida, Gisele Caravina; Matsushita, Marcus M; Clara, Carlos; Neder, Luciano; Viana-Pereira, Marta; Honavar, Mrinalini; Castro, Lígia; Lopes, José Manuel; Carvalho, Bruno; Vaz, Rui Manuel; Máximo, Valdemar; Soares, Paula; Sobrinho-Simões, Manuel; Reis, Rui Manuel; Lima, Jorge

    2016-07-15

    Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurrent somatic mutations. In this study we aimed to determine the frequency and prognostic value of TERTp mutations and TERT rs2853669 SNP in 504 gliomas from Portuguese and Brazilian patients. TERTp mutations were detected in 47.8% of gliomas (216/452). Glioblastomas (GBM) exhibited the highest frequency of TERTp mutations (66.9%); in this glioma subtype, we found a significant association between TERTp mutations and poor prognosis, regardless of the population. Moreover, in a multivariate analysis, TERTp mutations were the only independent prognostic factor. Our data also showed that the poor prognosis conferred by TERTp mutations was restricted to GBM patients carrying the rs2853669 A allele and not in those carrying the G allele. In conclusion, the presence of TERTp mutations was associated with worse prognosis in GBM patients, although such association depended on the status of the rs2853669 SNP. The status of the rs2853669 SNP should be taken in consideration when assessing the prognostic value of TERTp mutations in GBM patients. TERTp mutations and the rs2853669 SNP can be used in the future as biomarkers of glioma prognosis. PMID:26914704

  3. IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population.

    Yang, S X; Chen, F; Zhang, J W; Sun, Z Q; Chen, B P

    2016-01-01

    IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16.0 (SPSS Inc., Chicago, IL, USA). Using conditional logistic regression analysis, the TC and CC genotypes of rs4778889 exhibited a higher risk of RCC, with adjusted ORs (and 95%CIs) of 1.79 (1.23-2.62) and 2.67 (1.29-5.69), respectively. Moreover, under dominant and recessive models, individuals carried the rs4778889 polymorphism was exhibited elevated RCC risk, with adjusted ORs (and 95%CI) of 1.93 (1.35-2.76) and 2.11 (1.05-4.45), respectively. No significant differences were observed in rs11556218 genotype frequencies between the study groups. In conclusion, the results of our study reveal an association between the IL-16 rs4778889 polymorphism and heightened risk of RCC. PMID:27323152

  4. The Role of CzcRS Two-Component Systems in the Heavy Metal Resistance of Pseudomonas putida X4

    Pulin Liu

    2015-07-01

    Full Text Available The role of different czcRS genes in metal resistance and the cross-link between czcRS and czcCBA in Pseudomonas putida X4 were studied to advance understanding of the mechanisms by which P. putida copes with metal stress. Similar to P. putida KT2440, two complete czcRS1 and czcRS2 two-component systems, as well as a czcR3 without the corresponding sensing component were amplified in P. putida X4. The histidine kinase genes czcS1 and czcS2 were inactivated and fused to lacZ by homologous recombination. The lacZ fusion assay revealed that Cd2+ and Zn2+ caused a decrease in the transcription of czcRS1, whereas Cd2+ treatment enhanced the transcription of czcRS2. The mutation of different czcRSs showed that all czcRSs are necessary to facilitate full metal resistance in P. putida X4. A putative gene just downstream of czcR3 is related to metal ion resistance, and its transcription was activated by Zn2+. Data from quantitative real-time polymerase chain reaction (qRT-PCR strongly suggested that czcRSs regulate the expression of czcCBA, and a cross-link exists between different czcRSs.

  5. Molecular Cloning and Characterization of Pollen Development Related Gene RsMF2 from Raphanus sativus L.

    ZHANG Tao; CAO Jia-shu

    2005-01-01

    In the paper, the full length cDNA of RsMF2 gene, homologous with the BcMF2 gene encoding pollen-specific polygalacturonase of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) was cloned from Raphanus sativus L. cv. Yuanbai by PCR, with a pair of primer designed according to the coding sequence of BcMF2. The largest opening reading frame of RsMF2 gene is 1 266 bp in length and encodes a protein of 421 amino acids with a predicted molecular mass of 43.9 kDa. Sequence analysis revealed that it has three potential N-glycosylation sites and one polygalacturonase active position (RVTCGPGHGLSVGS). And the first 32 amino acids of the predicted RsMF2 protein form a N-terminal hydrophobic domain which displays the properties of a signal peptide. The predicted secondary structure composition for the protein has 6.9% helix, 42.0% sheet and 51.1% loop. Four domains which are highly conserved in the whole plant and fungal PGs is present in RsMF2. Phylogenetic analysis showed that RsMF2 falls into the category of clade-C, which includes PGs related to pollen. These results indicate that RsMF2 may act as polygalacturonase related to pollen development.

  6. 基于RS232-USB转换器及LabVIEW平台下温湿度采集系统的设计%Design of test program for RS232-USB converter

    周静; 张蕾; 南洋

    2012-01-01

    本文将RS232-USB转换器及虚拟仪器技术应用于温湿度测量中,以LabVIEW为软件开发平台,以计算机为核心,配上传感器、RS232-LJSB转换器和相应软件,针对室内环境的温湿度进行实时精确的采集及测量,编写了数据处理程序和人机交互界面,将结果通过人机交互界面以数字的方式进行实时显示,显示了虚拟仪器技术在温湿度测量中应用的灵活性和其功能的强大性,同时体现了RS232-USB转换器的RS232串行口至USB口转换功能的稳定性。实验表明,该系统能实时准确地采集温湿度信息,并通过RS232口-USB口显示至PC上,达到了可视化的效果。%The application of the RS232-USB converter and virtual instrument in the measurement of temperature and humidity in the article, with LabVIEW as software development platform, using the computer as the core, with the sensor, the RS232-USB converter and the corresponding software, the indoor temperature and humidity of the environment, precise real-time collection and measurement, a data processing program and human-computer interaction interface, will the results man-machine interface to the digital approach for real-time display, display of virtual instrument technology in the measurement of temperature and humidity application flexibility and its function of the powerful ,At the same time reflects the RS232-USB converter RS232 serial port to the USB conversion function stability .Based on the experiment, the system can real-time and accurate acquisition of temperature and humidity information, and through RS232 - USB port display to the PC, achieved the visual effect.

  7. The Type 2 Diabetes Associated Minor Allele of rs2237895 KCNQ1 Associates with Reduced Insulin Release Following an Oral Glucose Load

    Brunak, Søren; Holmkvist, J; Banasik, K; Andersen, G; Unoki, H; Jensen, Thomas Skøt; Pisinger, C; Borch-Johnsen, K; Sandbaek, A; Lauritzen, T; Maeda, S; Hansen, T; Pedersen, O

    2009-01-01

    Polymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and...... risk of type 2 diabetes, previously reported for this variant, likely is mediated through an impaired beta cell function...... the less common diabetes risk alleles of rs2237892, rs2237897, or rs2283228. CONCLUSION: The minor C-allele of rs2237895 of KCNQ1, which has a prevalence of about 42% among Caucasians was associated with reduced measures of insulin release following an oral glucose load suggesting that the increased...

  8. Evaluation of ionic liquids as solvent for aromatic extraction: Experimental, correlation and COSMO-RS predictions

    Highlights: • BMimMSO4 and BMimNTf2 were studied as solvents to extract aromatic from aliphatic hydrocarbons. • Liquid + liquid equilibrium data were measured at 298.15 K and atmospheric pressure. • Selectivity and solute distribution ratio were obtained and compared with literature. • Experimental data were satisfactorily correlated using NRTL and UNIQUAC models. • COSMO-RS model was used as a predictive tool to describe the experimental LLE data for the studied ternary systems. -- Abstract: For the study of the separation of benzene or toluene from octane, nonane and cyclooctane, the ionic liquids 1-butyl-3-methylimidazolium methylsulfate, BMimMSO4, and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, BMimNTf2, were used as solvents. The (liquid + liquid) equilibria of the ternary systems {octane, or nonane, or (cyclooctane + benzene + BMimMSO4)}, and {(nonane + toluene + BMimMSO4) or BMimNTf2} at T = 298.15 K were determined, and an analysis of the influence of the structure of each compound was carried out. Besides, the experimental data have been compared with literature data with sulfolane as solvent. The experimental results obtained have been correlated using NRTL and UNIQUAC models. Finally, COSMO-RS has been used to predict the (liquid + liquid) equilibrium of the systems studied. The differences between the predicted and experimental values were used to evaluate the ability of the COSMO-RS model to describe the impact of the structure of the alkane, aromatic and ionic liquid on the (liquid + liquid) equilibria

  9. Modelling the circumstellar medium in RS Ophiuchi and its link to Type Ia supernovae

    Booth, R. A.; Mohamed, S.; Podsiadlowski, Ph.

    2016-03-01

    Recent interpretations of narrow, variable absorption lines detected in some Type Ia supernovae suggest that their progenitors are surrounded by dense, circumstellar material. Similar variations detected in the symbiotic recurrent nova system RS Oph, which undergoes thermonuclear outbursts every 20 years, making it an ideal candidate to investigate the origin of these lines. To this end, we present simulations of multiple mass transfer-nova cycles in RS Oph. We find that the quiescent mass transfer produces a dense, equatorial outflow, i.e. concentrated towards the binary orbital plane, and an accretion disc forms around the white dwarf. The interaction of a spherical nova outburst with these aspherical circumstellar structures produces a bipolar outflow, similar to that seen in Hubble Space Telescope imaging of the 2006 outburst. In order to produce an ionization structure that is consistent with observations, a mass-loss rate of 5 × 10-7 M⊙ yr-1 from the red giant is required. The simulations also produce a polar accretion flow, which may explain the broad wings of the quiescent H line and hard X-rays. By comparing simulated absorption line profiles to observations of the 2006 outburst, we are able to determine which components arise in the wind and which are due to the novae. We explore the possible behaviour of absorption line profiles as they may appear should a supernova occur in a system like RS Oph. Our models show similarities to supernovae like SN 2006X, but require a high mass-loss rate, dot{M} ˜ 10^{-6}-10-5 M⊙ yr-1, to explain the variability in SN 2006X.

  10. Screening and optimization of low-cost medium for Pseudomonas putida Rs-198 culture using RSM

    Yanjie Peng

    2014-12-01

    Full Text Available The plant growth-promoting rhizobacterial strain Pseudomonas putida Rs-198 was isolated from salinized soils from Xinjiang Province. We optimized the composition of the low-cost medium of P. putida Rs-198 based on its bacterial concentration, as well as its phosphate-dissolving and indole acetic acid (IAA-producing capabilities using the response surface methodology (RSM, and a mathematical model was developed to show the effect of each medium component and its interactions on phosphate dissolution and IAA production. The model predicted a maximum phosphate concentration in medium containing 63.23 mg/L inorganic phosphate with 49.22 g/L corn flour, 14.63 g/L soybean meal, 2.03 g/L K2HPO4, 0.19 g/L MnSO4 and 5.00 g/L NaCl. The maximum IAA concentration (18.73 mg/L was predicted in medium containing 52.41 g/L corn flour, 15.82 g/L soybean meal, 2.40 g/L K2HPO4, 0.17 g/L MnSO4 and 5.00 g/L NaCl. These predicted values were also verified through experiments, with a cell density of 10(13 cfu/mL, phosphate dissolution of 64.33 mg/L, and IAA concentration of 18.08 mg/L. The excellent correlation between predicted and measured values of each model justifies the validity of both the response models. The study aims to provide a basis for industrialized fermentation using P. putida Rs-198.

  11. Treatment of mine water and solid residues (RS) in San Rafael mining and milling complex

    San Rafael Mining and Milling Complex is located in Mendoza Province, in San Rafael Department, 38 km West from San Rafael city and 240 km south from Mendoza city, capital of the province. Activities related with yellow cake production were performed from 1979 to 1999. Nowadays the mine and the plant are in stand by. At the moment technical, economic and environmental studies are being done in order to restart the activities. Different kind of residues are accumulated in the site: a) Tailing; b) Sludges; c) Low grade ores; e) Waste rock; f) Mine water; g) Solid residues (RS). In this paper methodology to treat mine water and solid residues (RS) will be informed. a) Mine water: 800.000 m3 of mine water are accumulated in different open pit. Uranium, radium and arsenic are the main ions to take into account to treat the water. Several laboratory and pilot test have been performed in order to define the treatment of the water, according with the regulatory requirement. A methodology using anion exchange resin to fix uranium and precipitation using barium chloride and iron sulfate to separate radium and arsenic has been developed. b) Solid residues (RS): these residues (precipitates) have been produced by neutralization of effluents in a nuclear purification process (TBP process). They are accumulated in drums. These residues come from Cordoba plant, a factory which produces UO2 powder. The total content of uranium in the precipitate is 14.249 kg with an average uranium concentration of 1,33%. A methodology using sulfuric acid dissolution of the precipitates and anion exchange resin to recovery the uranium has been developed. (author)

  12. Prediction of water solubilities for selected PCDDs/PCCDFs with COSMO-RS model

    Oleszek-Kudlak, S.; Grabda, M.; Shibata, E.; Nakamura, T. [Inst. of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku Univ., Sendai (Japan); Rosik-Dulewska, C. [Inst. of Environmental Engineering of the Polish Academy of Sciences, Zabrze (Poland)

    2004-09-15

    Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are well identified contaminants ubiquitous in the environment. Of the various parameters that affect the fate and behavior of environmental organic compounds, water solubility is one of the most important. However, when we are studying the aqueous behavior of organic chemicals, we should also take into consideration and evaluate several parameters (temperature, salinity, dissolved organic matter) influencing their solubility. Among the 210 congeners (mono- to octa-chlorinated) of PCDDs and PCDFs, water solubility values are available for a few congeners only. The reported aqueous solubilities of PCDDs and PCDFs are often scattered, despite most of them having been measured by the generator column method, recognized as the most accurate for the determination of the water solubility of hydrophobic organic chemicals. These discrepancies reflect an important problem associated with difficulties in the preparation of the saturated solution and in the analytical measurements, particularly of compounds with a solubility below 1 ppb. In practice, the high cost of the experimental determinations also limits the field of research. In recent years, investigators have developed a number of calculational methods to predict the water solubility of organic chemicals. One of them is the Conductor-like Screening Model for Real Solvents (COSMO-RS) introduced by Klamt et al. This model was successfully used for finding the solubilities of chlorobenzenes (ClBZs) at a wider range of temperatures (from 5 to 60 C) and in a salty environment. In this study, we have applied COSMO-RS to determine the aqueous solubilities of 19 PCDDs/ PCDFs at 25 C. Additionally, we measured the solubilities of 7 PCDDs/PCDFs using the generator column method at 25 C. We used these data and those available from the literature to estimate the accuracy of the COSMO-RS calculations.

  13. DATABASE STRUCTURE FOR THE INTEGRATION OF RS WITH GIS BASED ON SEMANTIC NETWORK

    2001-01-01

    The integration of remote sensing (RS) with geographical information sy stem (GIS) is a hotspot in geographical information science.A good da tabase structure is important to the integration of RS with GIS,which should be b eneficial to the complete integration of RS with GIS,able to deal with the disag reement between the resolution of remote sensing images and the precision of GIS data,and also helpful to the knowledge discovery and exploitation.In this pap er,the database structure storing the spatial data based on semantic network is presented.This database structure has several advantages.Firstly,the spatial data is stored as raster data with space index,so the image processing can be done directly on the GIS data that is stored hierarchically according to the di stinguishing precision.Secondly,the simple objects are aggregated into compl ex ones.Thirdly,because we use the indexing tree to depict the relationship of aggregation and the indexing pictures expressed by 2_D strings to describe the topolo gy structure of the objects,the concepts of surrounding and region are expressed clearly and the semantic content of the landscape can be illustrated well.All the factors that affect the recognition of the objects are depicted in the facto r space,which provides a uniform mathematical frame for the fusion of the seman tic and non_semantic information.Lastly,the object node,knowledge node and th e indexing node are integrated into one node.This feature enhances the ability of system in knowledge expressing,intelligent inference and association.The ap plication shows that this database structure can benefit the interpretation of r emote sensing image with the information of GIS.

  14. Association of rs6983267 Polymorphism and Thyroid Cancer Susceptibility: A Systematic Review and Meta-Analysis.

    Li, Jingdong; Wang, Xiaofei; Dong, Jiahong

    2016-01-01

    BACKGROUND Recent genome-wide association studies have identified rs6983267 polymorphism as a key locus in the 8q24 region associated with multisite cancers. However, the information on its association with thyroid cancer is inconclusive. The aim of this study was to determine whether this locus is a risk factor for susceptibility to thyroid cancer by conducting a meta-analysis. MATERIAL AND METHODS Relevant studies were identified by searching PubMed and Embase databases. The pooled odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated. RESULTS A total of 4 studies including 2825 cases and 9684 controls were enrolled to this meta-analysis. The pooled data showed the G allele of the rs6983267 polymorphism is a risk factor for susceptibility to thyroid cancer (OR=1.08, 95%CI: 1.02-1.16, P=0.01). Significant associations were also found in homozygote comparison (GG vs. TT: OR=1.17, 95%CI: 1.03-1.33, P=0.02) and dominant model (GG+GT vs. TT: OR=1.13, 95%CI: 1.01-1.26, P=0.03). Borderline significant associations in similar directions were found in the recessive model (GG vs. GT+TT: OR=1.10, 95%CI: 0.99-1.22, P=0.07) and heterozygote comparison (GT vs. TT: OR=1.10, 95%CI: 0.99-1.24, P=0.09). CONCLUSIONS Our meta-analysis shows that the rs6983267 G>T polymorphism might be associated with higher risk of thyroid cancer. Further research with larger sample sizes and full investigation of confounding risk factors is needed to confirm or revise our conclusions. PMID:27251952

  15. Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

    Melanie Glocke

    2013-09-01

    Full Text Available Background: Calcitriol, a key player in the regulation of mineral metabolism, influences, directly or by increasing plasma Ca2+ and phosphate levels, a multitude of physiological functions, such as bone mineralization, cell proliferation, immune response, carbohydrate metabolism, blood pressure, platelet reactivity, gastric acid secretion, cognitive function and mood. Calcitriol is mainly effective by stimulation of the Vitamin D receptor VDR. The responsiveness of VDR may be affected by gene variants, such as the FokI polymorphism (rs2228570. The GG gene variant is expected to be more active than the GA or AA gene variant. The present study explored the impact of VDR rs2228570 on survival and health of oldest old individuals (> 90 years. Methods: 101 individuals > 90 years were examined and genotyped. As a result, the prevalence of GG, GA & AA was 36 (10 ♂, 26♀, 52 (24 ♂, 28♀ and 13 (4 ♂, 9♀, respectively, a prevalence not significantly different from the frequency in public available dbSNP and a population (n = 208 of young volunteers (average age 49 years. Results: As compared to carriers of GG, carriers of AA and/or GA displayed significantly (p lower diastolic blood pressure (significant only in ♂, higher instrumental activity of daily life (IADL score and more frequent hospital visits (significant only in ♂, significantly lower prevalence of depression (significant in ♀+♂, renal disease (significant only in ♀, allergy, peptic ulcer and urolithiasis (significant only in ♂, as well as significantly higher prevalence of transitoric ischemic attacks. In a younger population a German version of the NEO-FFI, allowing reliable and valid assessment of personality, revealed decreased neuroticism (significant only in ♂ and increased extraversion in AA carriers. Conclusion: The Vitamin D receptor gene variant VDR rs2228570 has only little impact on life span but may affect a variety of pathophysiologically relevant functions

  16. (Solid + liquid) equilibria predictions of ionic liquid containing systems using COSMO-RS

    Highlights: ► (Solid + liquid) equilibria (SLE) prediction on IL systems. ► Use of COSMO-RS model. ► Quantitative agreement with effect of temperature. - Abstract: (Solid + liquid) equilibria (SLE) prediction are an important phase equilibria property for ionic liquid (IL) mixtures especially when the IL exists as a solid. In this work, the SLE for the binary systems of (IL + thiophene) consisting of the ILs: n-butyl-4-methylpyridinium tosylate [BM4Py][TOS], n-butyl-3-methylpyridinium tosylate [BM3Py][TOS], n-hexyl-3-methylpyridinium tosylate [HM3Py][TOS], and 1,4-dimethylpyridinium tosylate [M1,4Py][TOS] are predicted using the quantum chemical based COSMO-RS (COnductor like Screening MOdel for Real Solvents) model. Initially, benchmarking studies are performed on binary mixtures which are known beforehand. The values of the predicted solubility are then compared with the experimental results by calculating the root mean square error (RMSE). The SLE predictions of the solubility of pyrene and dibenzothiophene in five different solvents were carried out giving an average RMSE of 4%. Further the applicability of COSMO-RS to binary systems consisting of (ionic liquid + alcohol) mixtures and (ionic liquid + hydrocarbons) are predicted. The ionic liquids concerned are n-butyl-3-methylpyridinium tosylate [BM3Py][TOS] while the alcohols and hydrocarbons are 1-butanol, 1-hexanol, 1-octanol, 1-decanol, and benzene, toluene, ethylbenzene, n-propylbenzene respectively. The experimental data for the ionic liquid [BM4Py][TOS] with thiophene gave the smallest deviation of 10.2%. The overall RMSE for IL–thiophene, IL–alcohol, and IL–hydrocarbons were 15%, 17.2% and 12.9% respectively. Thus the predicted solubility values were found to be in reasonable agreement with the experimental values.

  17. 兔豆状囊尾蚴TpRS1基因的克隆及其序列分析%Cloning and Sequence Analysis of TpRS1 Gene from Cysticercus pisiformis

    韩乐乐; 李作磊; 苟惠天; 孙晓林

    2014-01-01

    旨在研究兔豆状囊尾蚴TpRS1的功能,根据GenBank中猪带绦虫RS1 cDNA序列设计引物,以豆状囊尾蚴总RNA为模板,利用RT-PCR技术首次克隆到兔豆状囊尾蚴TpRS1的完整开放阅读框序列,并利用生物信息学软件对该基因及其编码蛋白的基本理化性质、疏水性、信号肽、二级结构和抗原位点等方面进行了预测和分析。结果表明,兔豆状囊尾蚴TpRS1的cDNA序列为275 bp的基因片段,该序列含有一个由258个核苷酸组成的开放阅读框,编码85个氨基酸。其编码蛋白疏水性,分子质量为9.6 kD,理论等电点为9.07。TpRS1二级结构中α螺旋占70.59%,β折叠占5.88%,其余23.53%为无规卷曲,TpRS1没有信号肽序列,同源性分析表明与其他带科绦虫的一致性在72%以上,系统进化分析表明与泡状带绦虫处于同一进化分支。%To study the function of TpRS1 gene from Cysticercus pisiformis, the open reading frame(ORF)cDNA sequence of TpRS1 gene was cloned by RT-PCR from C. pisiformis total RNA with primers derived from Taenia solium RS1 gene sequence in the GenBank database. Biochemical properties, secondary structure, signal, hydrophobicity and antigenicity in TpRS1 protein were predicted by bioinformatics tools. The results indicated that TpRS1 cDNA sequence contained an ORF of 258 nucleotides and the deduced protein consisted of 85 amino acids with the theoretical molecular weight of 9.6 kD and isoelectric point of 9.07. Analysis of secondary structure revealed 70.59%and 5.88%ofα-helix andβ-strands, respectively, and others were loop. The signal peptide sequence of TpRS1 were not identified. TpRS1 protein sequence showed more than 72%identity with other Taenia spp.. Phylogenetic analysis indicated that TpRS1 located in the same clade with Taenia hydatigena.

  18. Simple test for high Jc and low Rs superconducting thin films

    Sundaresan, A; Tanaka, Y.; A. Iyo; Kusunoki, M; Ohshima, S.

    2003-01-01

    A simple method, fishing high-Tc superconductor thin films out of liquid nitrogen bath by a permanent magnet (field > Hc1) due to the effect of high flux pinning, has been suggested to identify films having high critical current density (Jc > 106 A/cm2 at 77 K) and thus a low microwave surface resistance (Rs). We have demonstrated that a Nd-Fe-B magnet, having a maximum field of ~ 0.5 T, could fish out Tl-1223 superconducting thin films on LSAT substrate with a thickness of ~ 5000 Angstrong h...

  19. Verifying the modes of cyclic conjugation in tetrabenzo[bc,ef,op,rs]circumanthracene

    Gutman Ivan

    2012-01-01

    Full Text Available Cyclic conjugation in the "empty" central ring of tetrabenzo- [bc,ef,op,rs]circumanthracene (TBCA is stronger than in its neighboring "nonempty" rings, contradicting the predictions of Kekulè-structure-based theoretical models. Earlier examples of such anomalous cyclic conjugation were observed in highly strained, non-planar benzenoid systems. Because the molecule of TBCA is perfectly planar and strain-free, its cyclic conjugation pattern could be tested and verified by means of high-level, B3LYP/6- 311+G(d,p, ab initio DFT calculations.

  20. Nutritional situation of Kaingangs children attending indigenous state school / Monte Caseiros area - Muliterno (RS)

    Ernesto Grazziotin Longhi; Jeanine Eggers Caramori

    2010-01-01

    At present, we undergo a nutritional transition, that is, from malnutrition to obesity, and it is known that it presents deleterious effects to health. A sample of 94 children from 4 to 14 years, resident in Aldeia Monte Caseiros, Muliterno (RS) was studied. The predominance of nutritional deficits determined were 5.08% for the weight index for the age, of 22.03% for the height index for the age and obesity/overweight, of 8.57% for adolescents, and 10.16% for children. It is conclude...