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A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on enzyme and cellular potency. In addition, the impact of the absolute stereochemical configuration on cellular potency and oral mouse pharmacokinetics is described.

UK PubMed Central (United Kingdom)

The extensive membrane network of the endoplasmic reticulum (ER) is physically juxtaposed to and functionally entwined with essentially all other cellular compartments. Therefore, the ER must sense...Full Text Available

UK PubMed Central (United Kingdom)

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing...Full Text Available

CERN Document Server

Two-tier networks, comprising a conventional cellular network overlaid with shorter range hotspots (e.g. femtocells, distributed antennas, or wired relays), offer an economically viable way to improve cellular system capacity. The capacity-limiting factor in such networks is interference. The cross-tier interference between macrocells and femtocells can suffocate the capacity due to the near-far problem, so in practice hotspots should use a different frequency channel than the potentially nearby high-power macrocell users. Centralized or coordinated frequency planning, which is difficult and inefficient even in conventional cellular networks, is all but impossible in a two-tier network. This paper proposes and analyzes an optimum decentralized spectrum allocation policy for two-tier networks that ...

UK PubMed Central (United Kingdom)

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

CERN Document Server

Cellular networks are in a major transition from a carefully planned set of large tower-mounted base-stations (BSs) to an irregular deployment of heterogeneous infrastructure elements that often additionally includes micro, pico, and femtocells, as well as distributed antennas. In this paper, we develop a tractable, flexible, and accurate model for a downlink heterogeneous cellular network (HCN) consisting of K tiers of randomly located BSs, where each tier may differ in terms of average transmit power, supported data rate and BS density. Assuming a mobile user connects to the strongest candidate BS, the resulting Signal-to-Interference-plus-Noise-Ratio (SINR) is greater than 1 when in coverage, Rayleigh fading, we derive an expression for the probability of coverage (equivalently outage) over the entire network under both open and closed access, which assumes a strikingly simple ...

Energy Technology Data Exchange (ETDEWEB)

The hypothesis that accumulation against sizable chemical gradients of free (non-phosphorylated) 2-deoxy-D-glucose (2dGlc) in isolated rat adipocytes results from an intracellular compartmentation of free hexose was investigated. Cells exposed to 20 ..mu..g/ml digitonin for 10' demonstrated an increased plasma membrane permeability indexed by increased L-glucose entry rates and cellular (presumably cytosolic) protein and K/sup +/ loss. Functional integrity of intracellular organelles was indicated by the ability of the cells to support ATP-driven /sup 45/Ca/sup 2 +/-uptake. Equilibrium 3-O-methylglucose (3-O-MG, a non-accumulated hexose) levels were unaffected. These data suggest a specific permeabilizing action of digitonin at the plasma membrane having no effect on intracellular organelles or passively distributed solutes. Upon addition of digitonin, free 2dGlc fell from ...

CERN Document Server

This paper presents an uplink capacity analysis and interference avoidance technique for a femtocell based two-tier DS-CDMA network using shared spectrum. Assuming randomly distributed macrocell users and femtocell base stations (BS), we evaluate a network-wide area spectral efficiency metric called the operating contour (OC) defined as the feasible combinations of the average macrocell users and femtocell BS per cell-site that meet a target outage constraint $\\epsilon$. A contribution of this work is an accurate characterization of the uplink outage probability taking cross-tier power control, path-loss and shadowing effects into account. We show that a time-hopped CDMA physical layer coupled with sectorized receive antennas shows dramatic performance improvements in both light and heavily loaded two-tier networks, relative to a split spectrum two-tier network with omnidirectional femtocell antennas. ...

CERN Document Server

We consider relay selection technique in a cooperative cellular network where user terminals act as mobile relays to help the communications between base station (BS) and mobile station (MS). A novel relay selection scheme, called Joint Uplink and Downlink Relay Selection (JUDRS), is proposed in this paper. Specifically, we generalize JUDRS in two key aspects: (i) relay is selected jointly for uplink and downlink, so that the relay selection overhead can be reduced, and (ii) we consider to minimize the weighted total energy consumption of MS, relay and BS by taking into account channel quality and traffic load condition of uplink and downlink. Information theoretic analysis of the diversity-multiplexing tradeoff demonstrates that the proposed scheme achieves full spatial diversity in the quantity of cooperating terminals in this network. And numerical results are provided to further confirm a significant energy efficiency ...

British Library Electronic Table of Contents (United Kingdom)

Background: We consider cells as biological systems that process information by means of molecular codes. Many studies analyze cellular information processing exclusively in syntactic terms (e.g., by measuring Shannon entropy of sets of macromolecules), and abstract completely from semantic aspects that are related to the meaning of molecular information. Methods: This mini-review focusses on semantic aspects of molecular information, particularly on codes that organize the semantic dimension of molecular information. First, a general conceptual framework for describing molecular information is proposed. Second, some examples of molecular codes are presented. Third, a mathematical approach that makes the identification of molecular codes in reaction networks possible, is developed. Results...

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Interactive seismic processing systems for editing noisy seismic traces and picking the first-break refraction events have been developed using a neural network learning algorithm. The authors employ a back propagation neural network (BNN) paradigm modified to improve the convergence rate of the BNN. The BNN is interactively trained'' to edit seismic data or pick first breaks by a human processor who judiciously selects and presents to the network examples of trace edits or refraction picks. The network then iteratively adjusts a set of internal weights until it can accurately duplicate the examples provided by the user. After the training session is completed, the BNN system an then process new data sets in a manner that mimics the human processor. Synthetic modeling studies indicated that the BNN uses many of the same subjective criteria that humans employ in editing and picking ...

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By using the continuation theorem of coincidence degree theory and constructing suitable Lyapunov functions, we study the existence and stability of periodic solution for shunting inhibitory cellular neural networks (SICNNs) with delays x-bar {sub ij}(t)=-a{sub ij}(t)x{sub ij}(t)--bar B{sup kl}-bar Nr(i,j)B{sub ij}{sup kl}(t)f{sub ij}(x{sub kl}(t))x{sub ij}(t)--bar C{sup kl}-bar Nr(i,j)C{sub ij}{sup kl}(t)g{sub ij}(x{sub kl}(t-{tau}{sub kl}))x{sub ij}(t)+L{sub ij}(t)

KoreaScience (Korea)

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CERN Document Server

Local access network technologies

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Short communication.

UK PubMed Central (United Kingdom)

We present the formulation and testing of a mathematical model for the kinetics of homotypic cellular aggregation. The model considers cellular aggregation under no-flow conditions as a two-step process....Full Text Available

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The origin of the epithelial and myoepithelial cells in the human breast has not been delineated. In this study we have addressed whether luminal epithelial cells and myoepithelial cells are vertically connected, i.e., whether one is the precursor for the other. We used a primary culture assay allowing preservation of basic phenotypic traits of luminal epithelial and myoepithelial cells in culture. The two cell types were then separated immunomagnetically using antibodies directed against lineage-specific cell surface antigens into at best 100% purity. The cellular identity was ascertained by cytochemistry, immunoblotting, and 2-D gel electrophoresis. Luminal epithelial cells were identified by strong expression of cytokeratins 18 and 19 while myoepithelial cells were recognized by expression of vimentin and {alpha}-smooth muscle actin. We used a previously devised culture medium (CDM4) that allows vigorous expansion of ...

CERN Document Server

Regulatory genes called small RNAs (sRNAs) are known to play critical roles in cellular responses to changing environments. For several sRNAs, regulation is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs). The nonlinearity inherent in this regulatory scheme indicates that exact analytical solutions for the corresponding stochastic models are intractable. Here, we present a variational approach to analyze a well-studied stochastic model for regulation by sRNAs via coupled degradation. The proposed approach is efficient and provides accurate estimates of mean mRNA levels as well as higher order terms. Results from the variational ansatz are in excellent agreement with data from stochastic simulations for a wide range of parameters, including regions of parameter space where mean-field approaches break down. The proposed approach can be applied to quantitatively model stochastic gene expression in complex regulatory ...

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... ADVANCED NETWORK SECURITY PROJECT Indiana University ... 4. TITLE AND SUBTITLE ADVANCED NETWORK SECURITY PROJECT ...

UK PubMed Central (United Kingdom)

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which...Full Text Available

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No abstract prepared.

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PMID:10175525

UK PubMed Central (United Kingdom)

The generation of synthetic forms of cellular life requires solutions...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundRecessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1). Gucy2d...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIn current comparative proteomics studies, the large number of images generated by 2D gels is currently compared using spot matching algorithms. Unfortunately, differences...Full Text Available

CERN Document Server

Networked Digital Library of Theses and Dissertations

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This paper presents a supernetwork equilibrium model integrating supply chain networks with a transport network, namely, a supply chain-transport supernetwork equilibrium model. The model takes into account the behaviour of freight carriers and transport network users to endogenously determine the transport costs generated in the supply chain networks. The interaction between transport network and supply chain networks can also be examined. Results of the numerical tests reveal that the improvement of transport network could enhance the efficiency of supply chain networks. The paper makes contributions to modelling of supply chain networks as well as to that of transport networks.

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For InAs-GaAs based quantum dot lasers emitting at 1300 nm, digital modulation showing an open eye pattern up to 12 Gb s{sup -1} at room temperature is demonstrated, at 10 Gb s{sup -1} the bit error rate is below 10{sup -12} at -2 dB m receiver power. Cut-off frequencies up to 20 GHz are realised for lasers emitting at 1.1 {mu}m. Passively mode-locked QD lasers generate optical pulses with repetition frequencies between 5 and 50 GHz, with a minimum Fourier limited pulse length of 3 ps. The uncorrelated jitter is below 1 ps. We use here deeply etched narrow ridge waveguide structures which show excellent performance similar to shallow mesa structures, but a circular far field at a ridge width of 1 {mu}m, improving coupling efficiency into fibres. No beam filamentation of the fundamental mode, low a-factors and strongly reduced sensitivity to optical feedback are observed. QD lasers are thus superior to QW lasers for any system or ...

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... UNCLASSIFIED The 60 Minute Network Security Guide ... 15. SUBJECT TERMS IATAC Collection; information security; network security 16. ...

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This article is a story of networking of palliative care at the corporate level. This gives an insight that if you have will and dedication then you can imagine and make it true that networking can...Full Text Available

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... TITLE (Indlude Security Classifkcation) Human Factors in Network Security 12. ... FIELD GROUP SUBGROUP Human Factors, Network, Security 19. ...

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Evaluation and interpretation of CT colonography is based on both 2D and 3D techniques. The 2D techniques are popular mainly because the time needed for evaluation is short. The 3D techniques allow better definition than the 2D techniques, especially of polyps close to folds or at the base of a fold. The evaluation strategies generally accepted so far (primarily 2D, with 3D for problem cases, or vice versa) demand knowledge of both 2D and 3D techniques. Newer 3D visualization techniques help make it possible to acquire more complete and faster recording particularly of areas that are not easily accessible to endoscopic examination. These user-friendly developments are thus well suited to improving the detection and the security of detection of polyps. It must be remembered that ...

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BackgroundSilica nanoparticles (SiNPs) are being formulated for cellular imaging and for nonviral gene delivery in the central nervous system (CNS), but it is unclear what potential...Full Text Available

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Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in cells resulting in oxidation of cellular components and consequent loss of cellular function. Oxidative...Full Text Available

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Optical coherence microscopy (OCM) is a promising technique or high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging...Full Text Available

UK PubMed Central (United Kingdom)

Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processed by cellular...Full Text Available

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Lecturo on Firewalls, VPNs, Intrusion Detection, and filters

KoreaScience (Korea)

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... analyze importance sampling schemes for stochastic networks ... an interesting mixed open/closed queueing network ... with a suitable terminal condition ...

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... Accession Number : ADA060007. Title : Issues in Computer Network Security. Descriptive Note : Technical rept.,. Corporate ...

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Promises of ubiquitous control of the physical environment by large-scale wireless sensor networks

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Page 1. Adaptive system and method for responding to computer network security attacks Abstract A dynamic network security ...

UK PubMed Central (United Kingdom)

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular...Full Text Available

CERN Document Server

Motivated by the numerical investigations of Laval, Dubrulle & Nazarenko (1999), we develop a quasilinear theory of the 2D Euler equation and derive an integro-differential equation for the evolution of the coarse-grained vorticity. This equation respects all the invariance properties of the Euler equation and conserves angular momentum in a circular domain and linear impulse in a channel (as well as in an infinite domain). The explicit energy is not rigorously conserved as it is partly transfered into fine-grained fluctuations but the total energy is conserved. We prove a H-theorem for the Fermi-Dirac entropy and make the connection with statistical theories of 2D turbulence.

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For coupled quantum wires and dots, tunneling effects and coherent transport for quantum computing are being studied. In 2D systems, electron-hole bilayers for exciton...

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The processes of neuronal outgrowth and guidance have typically been studied in classic 2D cell culture systems that do not recapitulate topographical cues present in the in vivo extracellular matrix...Full Text Available

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No abstract prepared.

British Library Electronic Table of Contents (United Kingdom)

A 2-D model has been proposed to investigate the approximate estimation of the natural convection heat loss from modified cavity receiver of without insulation (WOI) and with insulation (WI) at the bottom of the aperture plane in our previous article. In this paper, a 3-D numerical model is presented to investigate the accurate estimation of natural convection heat loss from modified cavity receiver (WOI) of fuzzy focal solar dish concentrator. A comparison of 2-D and 3-D natural convection heat loss from a modified cavity receiver is carried out. A parametric study is carried out to develop separate Nusselt number correlations for 2-D and 3-D geometries of modified cavity receiver for estimation of convective heat loss from the receiver. The results show that the 2-D and 3-D are comparabl...

CERN Document Server

To understand dynamic developmental processes, living tissues must be imaged frequently and for extended periods of time. Root development is extensively studied at cellular resolution to understand basic mechanisms underlying pattern formation and maintenance in plants. Unfortunately, ensuring continuous specimen access, while preserving physiological conditions and preventing photo-damage, poses major barriers to measurements of cellular dynamics in indeterminately growing organs such as plant roots. We present a system that integrates optical sectioning through light sheet fluorescence microscopy with hydroponic culture that enables us to image at cellular resolution a vertically growing Arabidopsis root every few minutes and for several consecutive days. We describe novel automated routines to track the root tip as it grows, track cellular nuclei and identify cell divisions. We demonstrate the ...

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In vitro cytocompatibility and cellular interactions of lauric acid and dextran-coated magnetite nanoparticles were evaluated with two different cell lines (mouse fibroblast and human cervical carcinoma). Lauric acid-coated magnetite nanoparticles were less cytocompatible than dextran-coated magnetite nanoparticles and cellular uptake of lauric acid-coated magnetic nanoparticles was more than that of dextran-coated magnetite nanoparticles. Lesser cytocompatibility and higher uptake of lauric acid-coated magnetite nanoparticles as compared to dextran-coated magnetic nanoparticles may be due to different cellular interactions by coating material. Thus, coating plays an important role in modulation of biocompatibility and cellular interaction of magnetic nanoparticles.

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A typical incident response pits technicians against networks that aren't prepared forensically. [1, 2] If practitioners do consider collecting network forensic data, they face a choice between expending extraordinary effort (time and money) collecting forensically sound data, or simply restoring the network as quickly as possible. In this context, the concept of organizational network forensic readiness has emerged. This paper proposes a methodology for "operationalizing" organizational network forensic readiness. The methodology, and the theoretical analysis that led to its development, are offered as a conceptual framework for thinking about more efficient, proactive approaches to digital forensics on networks.

UK PubMed Central (United Kingdom)

Our goal is to determine an optimized image-guided setup by comparing setup errors determined by two-dimensional (2D) and three-dimensional (3D) image guidance for head and neck cancer (HNC)...Full Text Available

CERN Document Server

Connectivity and capacity are two fundamental properties of wireless multi-hop networks. The scalability of these properties has been a primary concern for which asymptotic analysis is a useful tool. Three related but logically distinct network models are often considered in the asymptotic analysis, i.e. the dense network model, the extended network model and the infinite network model, which consider respectively a network deployed in a finite area with a sufficiently large node density, a network deployed in a sufficiently large area with a fixed node density, and a network deployed in $\\Re^{2}$ with a sufficiently large node density. The infinite network model originated from continuum percolation theory and asymptotic results obtained from the infinite network model have ...

Science.gov (United States)

This manual is intended to provide a free resource on essential network security concepts for non-technical managers of small libraries. Managers of other small nonprofit or community organizations will also benefit from it. An introduction defines network security; outlines three goals of network security; discusses why a library should be concerned with network security; and describes limits of this work. The manual is divided into three main parts. Part One features the management issues related to network security: analyzing risk, developing a security plan and policy, the funding requirements libraries can expect in operating their networks, and implementing adequate security. Part Two describes the areas of computer networks that need to be secured, and provides a description of many of the security measures necessary for adequate ...

UK PubMed Central (United Kingdom)

This paper describes how a computerized MIS is used to assist HMO management to conduct utilization and quality of care review activities in a prepaid medical care network. The HMO is a ‘network’...Full Text Available

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Materials World Network: Cooperative Activity in Materials Research between US Investigators and ... Program Title: Materials World Network: Cooperative Activity in Materials Research between US ...

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A high-speed fiber-based network for the transmission and display of digitized full-motion cardiac images has been developed. Based on Asynchronous Transfer Mode (ATM), the network is scaleable, meaning...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The role of computers has become increasingly important for oil and gas field research and operations support. Today, the computer network is an integral part of the increasingly complex computing environment that exists in many companies. Computer networks allow users to efficiently share information, software, and hardware to support critical global communication needs. Because users are able to share software and hardware, the use of computer networks can also result in significant cost savings. This paper describes typical network loading and demand levels for shared software applications on a computer network that has been used for several years.

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'As part of the Computer Protection Plan, this Network Security Plan identifies the specific security measures used to protect Bechtel Hanford, Inc.'s (BHI's) enterprise network. The network consists of the communication infrastructure and information systems used by BHI to perform work related to the Environmental Restoration Contract (ERC) at the Hanford Site. It provides electronic communication between the ERC-leased facilities in Richland, Washington, and facilities located on the Hanford Site. Network gateways to other site and offsite networks provide electronic communication with the remainder of the Hanford community.'

UK PubMed Central (United Kingdom)

 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer...Full Text Available

UK PubMed Central (United Kingdom)

Prokaryotic genomes can be annotated based on their structural, operational, and functional properties. These annotations provide the pivotal scaffold for understanding cellular functions on a genome-scale,...Full Text Available

UK PubMed Central (United Kingdom)

Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms...Full Text Available

UK PubMed Central (United Kingdom)

Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors (TRs) mediate the biological...Full Text Available

UK PubMed Central (United Kingdom)

Advances in modern neuroscience require the identification of principles that connect different levels of experimental analysis, from molecular mechanisms to explanations of cellular functions,...Full Text Available

UK PubMed Central (United Kingdom)

Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to...Full Text Available

UK PubMed Central (United Kingdom)

CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein...Full Text Available

Science.gov (United States)

5.2 Network Security. The features listed below can be used to help safeguard UNIX ...... The LaRCSCAN non-intrusive network security scanner package, ...

CERN Document Server

In this report, I surveyed the cognitive radio technique in wireless networks. Researched several kinds of cognitive techniques about their advantages and disadvantages.

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NETWORK SECURITY, is revised to reflect, as item "g", incorporation ..... The Contractor shall provide support for the network security of the ...

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... Accession Number : ADA298752. Title : Placement of Network Security Services for Secure Data Exchange. Descriptive Note : Final rept.,. ...

British Library Electronic Table of Contents (United Kingdom)

The tremendous growth of wireless technologies has introduced the potential of continuous service adaptation to the users' needs by giving them the ability to be able to select and access the proper network based on different criteria. Moreover, next generation wireless networks have been designed to provide support for multimedia services, with different traffic characteristics and different Quality of Service (QoS) guarantees. However, the expansion of Wireless Local Area Networks (WLANs) and Worldwide Interoperability for Microwave Access (WiMAX) networks poses new research era in the decision of the access network selection. In this paper, the existing access network selection schemes are classified into three categories: the network-centric, the user-centric and the collaborative sche...

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... DTIC SELECTE z DEC 0 7, 1994 F THESIS NETWORK SECURITY AND THE NPS INTERNET FIREWALL by Jody L. Schivley September 1994 ...

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...Air Quality Monitoring Networks Products and Equipment Find and compare a variety of air quality monitoring networks products and equipment on the world's largest environmental industry portal. ...

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Jan 22, 2011 ... Title: Model checking for network security requirements via a flexible modeling framework. Authors: Powell, J. Gilliam, D. ...

Science.gov (United States)

... California where he is currently working on an AS in. Data Communication & Network Management as well as Microsoft. MCSE and Cisco CCNA certifications.

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A Composite Architecture for Network Security at JPL. Robert B. Mead, Tom G. Dearmond, and Joseph S. Sherif. JPL, California Institute of Technology ...

British Library Electronic Table of Contents (United Kingdom)

A two-dimensional (2D) lattice model with anisotropic resonant microstructures is found to provide an anisotropic band gap structure. A 2D continuum with anisotropic effective mass density is introduced to represent this lattice system. Two methods are proposed to derive the equivalent continuum. In the first method, the effective mass density of the equivalent continuum is obtained by matching the dispersion relations for harmonic waves propagating in the principal directions. The second approach employs an approximate estimation of the effective mass density by volume-averaging an effective mass that represents the resonant microstructure. For both equivalent continuum models, the effective mass density is frequency-dependent and may become negative in certain frequency ranges. Subsequen...

British Library Electronic Table of Contents (United Kingdom)

Abstract Background: Obstructive sleep apnea (OSA), a highly prevalent condition, is independently associated with increased risks of developing type 2 diabetes mellitus (T2D) and metabolic syndrome. It is unclear, however, if the severity of OSA has any impact on glycemic control among patients with T2D. We therefore aimed to determine the independent association between OSA severity and glycosylated hemoglobin (HbA1c) in patients with T2D. Methods: This was an observational cross-sectional study of 52 consecutive patients attending the diabetes obesity clinic between January 2008 to February 2010 with risk factors for sleep apnea and who underwent polysomnography study. Clinical, demographic, and lifestyle data were recorded using a questionnaire. Results: Prevalence of OSA in this clini...

Wastenet

...) Abstract: Fluorescence microscopic imaging is widely used in biomedical research to study molecular and cellular processes in cell culture or tissue samples. This is motivated by the high inherent sensitivity of fluorescence techniques, the spatial resolution that compares favorably with cellular dimensions, the stability of the fluorescent labels used and the sophisticated strategies that have been developed for selectively labeling target molecules. More recently, two and ...

UK PubMed Central (United Kingdom)

Fifty-six tuberculosis patients and twenty-eight control subjects were evaluated in a comprehensive investigation of cellular and humoral immune function in pulmonary TB. The patient group showed significantly...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The diffusion of ion beam injected self-interstitials (I) and their interaction with impurities in crystalline Si has been investigated and modeled. In particular, the I-substitutional carbon (C) interactions have been studied, using a molecular-beam-epitaxy grown Si{sub 1-y}C{sub y} layer interposed between the shallow I-source and a deeper B-spike (marker for I-concentration). Substitutional C atoms are shown to trap I's, to be removed from their substitutional sites, and to form stable precipitates into the C-rich region. The I-trapping mechanism was quantitatively studied by a simulation code. The reactions causing trapping and deactivation are described. In addition, the boron markers approach was extended to the two dimensional (2D) diffusion. High resolution scanning capacitance microscopy was used for quantitative measurements of the 2D boron transient enhanced diffusion induced on a ...

UK PubMed Central (United Kingdom)

Although two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) has been used as the standard proteomic approach for separating proteins in a complex mixture, this technique has many drawbacks....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA...Full Text Available

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... ions. MATERIALS AND METHODS Cell Culture Culture of NT2/D1 cells was carried out as described previously (18, 19). NT2 cells were plated at a density of 2. ... ...

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The major problem of measurement of a power spectral density (PSD) distribution of the surface heights with surface profilometers arises due to the unknown Modulation Transfer Function (MTF) of the instruments. The MTF tends to distort the PSD at higher spatial frequencies. It has been suggested [Proc. SPIE 7077-7, (2007), Opt. Eng. 47 (7), 073602-1-5 (2008)] that the instrumental MTF of a surface profiler can be precisely measured using standard test surfaces based on binary pseudo-random (BPR) patterns. In the cited work, a one dimensional (1D) realization of the suggested method based on use of BPR gratings has been demonstrated. Here, we present recent achievements made in fabricating and using two-dimensional (2D) BPR arrays that allow for a direct 2D calibration of the instrumental MTF. The 2D BPRAs were used as standard test surfaces for ...

UK PubMed Central (United Kingdom)

Summary5-Aminoimidazole-4-carboxamide-1-;2;-d-ribofuranoside (AICA riboside) has been extensively used in vitro and in vivo to...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A 2-D model has been proposed to investigate the approximate estimation of the natural convection heat loss from modified cavity receiver of without insulation (WOI) and with insulation (WI) at the bottom of the aperture plane in our previous article. In this paper, a 3-D numerical model is presented to investigate the accurate estimation of natural convection heat loss from modified cavity receiver (WOI) of fuzzy focal solar dish concentrator. A comparison of 2-D and 3-D natural convection heat loss from a modified cavity receiver is carried out. A parametric study is carried out to develop separate Nusselt number correlations for 2-D and 3-D geometries of modified cavity receiver for estimation of convective heat loss from the receiver. The results show that the 2-D and 3-D are comparable only at higher angle of ...

Science.gov (United States)

... and mean rainfall rates, Rm, in the liquid hydrometeor layers using the .... large latitudinal movement of cirrus cloud cover with the changing seasons. ... We study the statistical distribution of PSCs by particle composition using .... the high resolution Cloud Particle Imager (CPI) and standard PMS 2D-C and ...

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PMID:21398174

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PMID:12556767

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Not Available

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Not Available

Medline Plus

... parent groups that are wonderful and lots of networking and a lot of interactions between the foundations, ...

Energy Technology Data Exchange (ETDEWEB)

Implementing a successful local area network for a publications work-group isn`t as simple as the scarcity of information on the subject would suggest. Making a network work for your requires careful planning, developing and acquiring network expertise, transforming your group`s patterns of working together, and carefully managing the human and technological resources.

Energy Technology Data Exchange (ETDEWEB)

This thesis investigates the application of artificial neural networks for the compression of image data. An algorithm is developed using the competitive learning paradigm which takes advantage of the parallel processing and classification capability of neural networks to produce an efficient implementation of vector quantization. Multi-Stage, tree searched, and classification vector quantization codebook design are adapted to the neural network design to reduce the computational cost and hardware requirements. The results show that the new algorithm provides a substantial reduction in computational costs and an improvement in performance.

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International Nuclear Information System (INIS)

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be ...

Energy Technology Data Exchange (ETDEWEB)

We investigate the formation of nanostructures in 2D strained alloys on face centered cubic (111) surfaces by means of equilibrium Monte Carlo simulations. In the framework of an off-lattice model, we consider one monolayer of two bulk-immiscible adsorbates A and B with negative and positive misfit relative to the substrate, respectively. Simulations show that the adsorbates partly self-organize into island or stripe-like patterns. We show how these structures depend on the relative misfits, interaction, and concentration of components. The morphology is quite different for phase separation and intermixing regimes.

Science.gov (United States)

A computer model of an electrothermal accelerator has been developed which applies to the plasma generator as well as the gun barrel, and it for the first time allows study of the interdependent physical processes in both components simultaneously. The code comprises a 2D transient description of the plasma arc, a 2D, two-phase interior ballistics module, and a preprocessor delivering the required plasma physical data. Some results on the flow field, pressure and temperature in a typical accelerator are presented, and probable limitations on the performance of such a system are discussed. The code is to be applied to different concepts of electrothermal chemical guns.

Energy Technology Data Exchange (ETDEWEB)

Two classes of convergent algorithms for learning continuous functions (and also regression functions) that are represented by feedforward networks, are discussed. The first class of algorithms, applicable to networks with unknown weights located only in the output layer, is obtained by utilizing the potential function methods of Aizerman et al. The second class, applicable to general feedforward networks, is obtained by utilizing the classical Robbins-Monro style stochastic approximation methods. Conditions relating the sample sizes to the error bounds are derived for both classes of algorithms using martingale-type inequalities. For concreteness, the discussion is presented in terms of neural networks, but the results are applicable to general feedforward networks, in particular to wavelet networks. The algorithms can be directly adapted to concept learning ...

Energy Technology Data Exchange (ETDEWEB)

In both office and home environments, Ethernet represents the dominant networking technology in use. Ethernet is low cost and the networks are fairly understood by users. The author began by explaining the physical and data link layers of Ethernet, then touched on fibre-optic cables. The industrial protocols were discussed, followed by Ethernet network topology. The environmental robustness of Ethernet networks was reviewed, with a word of caution from the author, advising to properly evaluate whether Ethernet represents a mission-critical component of the substation, as substation control houses are not environmentally controlled spaces, often minimally heated and no cooling. Engineering access to station Integrated Electric Drives (IEDs). By properly connecting Ethernet networks, it is possible to access relays in the substations from desktop engineering workstations in the ...

Energy Technology Data Exchange (ETDEWEB)

This report describes the results obtained during Stage 13 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. A brief proposal for the continuation of this program in Stage 14 is also given at the end of the report. The program executed in Stage 13 consists of three parts and the work performed in each part is summarized below. 1. Study of criticality, neutron kinetics and neutron noise in molten salt reactors (MSR). Although the original goal of the investigations of the MSR in Stage 13 was to calculate the neutron noise induced by the fluctuations of the fuel temperature, the study, solution and interpretation of the static problem, as well as to define an approximate version of the point kinetic approximation was necessary to perform. As it turned out, these tasks in themselves were more involved, and also very edifying, to solve. Hence, in this report, we confine the study of the reactor physics of ...

Science.gov (United States)

Information security involves many branches of effort, including information assurance, host level security, physical security, and network security. Computer network security methods and implementations are given a top-down description to permit a medically focused audience to anchor this information to their daily practice. The depth of detail of network functionality and security measures, like that of the study of human anatomy, can be highly involved. Presented at the level of major gross anatomical systems, this paper will focus on network backbone implementation and perimeter defenses, then diagnostic tools, and finally the user practices (the human element). Physical security measures, though significant, have been defined as beyond the scope of this presentation.

CERN Document Server

A complex network approach on a rough fracture is developed. In this manner, some hidden metric spaces (similarity measurements) between apertures profiles are set up and a general evolutionary network in two directions (in parallel and perpendicular to the shear direction) is constructed. Also, an algorithm (COmplex Networks on Apertures: CONA) is proposed in which evolving of a network is accomplished using preferential detachments and attachments of edges (based on a competition and game manner) while the number of nodes is fixed. Also, evolving of clustering coefficients and number of edges display similar patterns as well as are appeared in shear stress, hydraulic conductivity and dilation changes, which can be engaged to estimate shear strength distribution of asperities.

Energy Technology Data Exchange (ETDEWEB)

A probabilistic method for assessing the profitability of reactive power compensation devices such as capacitors, static VAR compensators and generators, which improve network security, was described. Since network development is limited by environmental constraints, power networks are operated close to their limits. Because of this fact transmission network planning increasingly relies on techno-economic models to improve network security and profitability. The proposed method consists of analyzing large numbers of constrained power system states, extracted from power system simulation exercises. The paper describes details of the method and provides an example of a numerical application on a part of the French power transmission system. 10 refs., 8 figs.

Energy Technology Data Exchange (ETDEWEB)

Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. Many neural network pattern classifiers fail as one-class classifiers because they use open decision boundaries. To function as one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Coulomb Energy network (RCE). The ART 2-A neural ...

Energy Technology Data Exchange (ETDEWEB)

A system and method for generating global asynchronous signals in a computing structure. Particularly, a global interrupt and barrier network is implemented that implements logic for generating global interrupt and barrier signals for controlling global asynchronous operations performed by processing elements at selected processing nodes of a computing structure in accordance with a processing algorithm; and includes the physical interconnecting of the processing nodes for communicating the global interrupt and barrier signals to the elements via low-latency paths. The global asynchronous signals respectively initiate interrupt and barrier operations at the processing nodes at times selected for optimizing performance of the processing algorithms. In one embodiment, the global interrupt and barrier network is implemented in a scalable, massively parallel supercomputing device structure comprising a plurality of processing nodes interconnected ...

CERN Document Server

We consider network coding for networks experiencing worst-case bit-flip errors, and argue that this is a reasonable model for highly dynamic wireless network transmissions. We demonstrate that in this setup prior network error-correcting schemes can be arbitrarily far from achieving the optimal network throughput. We propose a new metric for errors under this model. Using this metric, we prove a new Hamming-type upper bound on the network capacity. We also show a commensurate lower bound based on GV-type codes that can be used for error-correction. The codes used to attain the lower bound are non-coherent (do not require prior knowledge of network topology). The end-to-end nature of our design enables our codes to be overlaid on classical distributed random linear network codes. Further, we free internal nodes from ...

British Library Electronic Table of Contents (United Kingdom)

Over the decades, basic research in life sciences has profited greatly from the study of the small unicellular fungal species Saccharomyces cerevisiae. This yeast turned out to be key for the identification and understanding of molecular mechanisms that underlay the basic functions of all eukaryotic cells. These include, but are not limited to, the regulatory mechanisms behind cellular reproduction (cell cycle control), cellular morphogenesis (cell polarity, cytoskeleton and membrane trafficking) and the management of cellular information (chromosome biology, transcription and translation). Rapid access to genomic information of many yeast species, combined with bioinformatics analyses, provide information on the evolutionary history of yeasts and the molecular ancestry of their constituen...

CERN Document Server

Many real-world networks are so large that we must simplify their structure before we can extract useful information about the systems they represent. As the tools for doing these simplifications proliferate within the network literature, researchers would benefit from some guidelines about which of the so-called community detection algorithms are most appropriate for the structures they are studying and the questions they are asking. Here we show that different methods highlight different aspects of a network's structure and that the the sort of information that we seek to extract about the system must guide us in our decision. For example, many community detection algorithms, including the popular modularity maximization approach, infer module assignments from an underlying model of the network formation process. However, we are not always as interested in how a system's network ...

British Library Electronic Table of Contents (United Kingdom)

Purpose - The service-dominant (S-D) logic views supply chains as value co-creation networks. These networks promote knowledge growth amongst network members via resource deployment and coordination. The exchange of knowledge and utilization of operant resources among the network members leads to co-created service offerings and value proposals for the end-users, with the ultimate goal of transforming end-user experiences to perceptions of superior value-in-use. The purpose of this paper is to develop an illustration of the value co-creation concept and use this illustration as guide to examine the research gaps that are yet to be tapped in the area where supply chain networks and S-D logic intersects. Design/methodology/approach - The literature on S-D logic is reviewed and research gaps ...

International Nuclear Information System (INIS)

In this article, the ability of artificial neural networks in prediction of separation in steady two dimensional boundary layer flows is studied. Data for network training is extracted from numerical solution of an ODE obtained from Von Karman integral equation with approximate one parameter Pohlhousen velocity profile. As an appropriate neural network, a two layer radial basis generalized regression artificial neural network is used. The results shows good agreements between the overall behavior of the flow fields predicted by the artificial neural network and the actual flow fields for some cases. The method easily can be extended to unsteady separation and turbulent as well as compressible boundary layer flows. (author)

British Library Electronic Table of Contents (United Kingdom)

The recent literature in the field of supply chain management emphasizes the role of inter-organizational networks and the integration of vertical reproduction networks (supply chains) in particular as a key factor for value creation. However, the literature includes little empirical evidence. This situation suggests the need to appraise investments in such networks or supply chains carefully. How can a decision maker reliably assess the effect of investing in inter-organizational network arrangements on firm value? This article takes up this issue and suggests a framework consisting of five components to help answer the question. The task of the framework is to support the structuring and revelation of the causal chain between investments in the network on the one hand and the effect of t...

Energy Technology Data Exchange (ETDEWEB)

This paper presents the application of artificial neural networks to adiabatic flame temperature prediction of hydrocarbon fuels. The investigation was conducted over a wide range of operating conditions in terms of fuel composition, pressure and temperature of reactants, fuel-air equivalence ratio and fuel vapour fraction. Several neural network models for predicting the flame temperature for different applicable fuel ranges were built and examined. The proper preparation of network training data and the appropriate choice of network parameters for achieving better prediction accuracy are discussed. The neural network prediction results were compared with those calculated by a thermodynamic and chemical equilibrium-based computer code - the NASA program CET89. It was shown that trained neural network models can provide the adiabatic flame temperature prediction ...

UK PubMed Central (United Kingdom)

Global acetylation of histone H4 is a mark of gene transcriptional activation. The c-Myc transcription factor binds to specific DNA sites in cellular chromatin and induces the acetylation of...Full Text Available

UK PubMed Central (United Kingdom)

The interactions between biochemical processes and mechanical signaling play important roles during various cellular processes such as wound healing, embryogenesis, metastasis, and cell migration. While...Full Text Available

UK PubMed Central (United Kingdom)

Altered structure, and hence function, of cellular macromolecules caused by oxidation can contribute to loss of physiological function with age. Here, we tested whether the lifespan of bats, which generally...Full Text Available

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Post-transcriptional nucleoside modifications fine-tune the biophysical and biochemical properties of transfer RNA (tRNA) so that it is optimized for participation in cellular processes. Here we report...Full Text Available

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ATP-binding cassette transporters (ABC transporters) utilize the energy of ATP hydrolysis to translocate an unusually diverse set of substrates across cellular membranes. ABCA4, also known as...Full Text Available

UK PubMed Central (United Kingdom)

We have identified the nonreceptor tyrosine kinase syk as a marker of differentiation/tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). Syk expression is lost in poorly differentiated PDAC...Full Text Available

UK PubMed Central (United Kingdom)

Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the...Full Text Available

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Cellular calcium transient alternans are beat-to-beat alternations in the peak cytosolic calcium concentration exhibited by cardiac cells during rapid electrical stimulation or under pathological conditions....Full Text Available

UK PubMed Central (United Kingdom)

It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic changes can be attributed to the activation...Full Text Available

UK PubMed Central (United Kingdom)

By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [³H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have...Full Text Available

UK PubMed Central (United Kingdom)

MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available

UK PubMed Central (United Kingdom)

PurposeNocturnal rhythms of gene expression in the retina are known to be both darkness- and circadian clock-dependent, but their role and cellular location are not well defined....Full Text Available

UK PubMed Central (United Kingdom)

Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Abstracts of research projects are presented in the following areas: measurements and special facilities; cellular and subcellular studies; physiology; behavior; environmental effects; modeling, scaling and dosimetry; and high voltage direct current. (ACR)

UK PubMed Central (United Kingdom)

Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic...Full Text Available

UK PubMed Central (United Kingdom)

Microglia provide immune surveillance for the brain through both the removal of cellular debris and protection against infection by microorganisms and “foreign” molecules. Upon...Full Text Available

UK PubMed Central (United Kingdom)

Cardiovascular modelling has been a major research subject for the last decades. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of...Full Text Available

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Mitochondrial heat shock protein 70 (mtHSP70) is found to play a primary role in cellular defense against physiological stress like exposure to environmental contaminants and helpful in the maintenance...Full Text Available

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Friends and colleagues remember John N. Brady, Ph.D., Chief of the Virus Tumor Biology Section of the Laboratory of Cellular Oncology, who died much too young at the age of 57 on April 27, 2009 of colon...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The authors calculated the stress-strain relation for elastomeric foam from an ab initio theory, which shows that the plateau and densification regions should be described by a hyperbola. The theory seems to agree reasonably well with experiment.

UK PubMed Central (United Kingdom)

BackgroundLipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe Gene Ontology (GO) is a well known controlled vocabulary describing the biological process, molecular function and cellular...Full Text Available

UK PubMed Central (United Kingdom)

The human immunodeficiency virus type 1 (HIV-1) packages its genomic RNA as a dimer of homologous RNA molecules that has to be selected among a multitude of cellular and viral RNAs. Interestingly, spliced...Full Text Available

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The intramembrane aspartyl protease γ-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases,...Full Text Available

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In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion,...Full Text Available

UK PubMed Central (United Kingdom)

Telomerase, a ribonucleoprotein enzyme that maintains telomere length, is crucial for cellular immortalization and cancer progression. Telomerase activity is attributed primarily to the expression of...Full Text Available

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Cellular hypertrophy is regulated by coordinated pro- and antigrowth machineries. Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth. This study was designed...Full Text Available

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Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecular...Full Text Available

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Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

UK PubMed Central (United Kingdom)

Background:Stem cells can differentiate into multiple cell types, and therefore can be used for cellular therapies, including tissue repair. However, the participation of stem cells...Full Text Available

Science.gov (United States)

... were given daily i.p. injections of either sesame oil (2.5 ml/kg, vehicle control) or VCD dissolved in sesame oil (80 mg/kg, 0.57 mmol/kg) for ... ...

UK PubMed Central (United Kingdom)

¹³C metabolic flux analysis (MFA) is the most comprehensive means of characterizing cellular metabolic states. Uniquely labeled isotopic tracers enable more focused analyses to probe...Full Text Available

UK PubMed Central (United Kingdom)

Objective: To evaluate effects of epigallocatechin-3-gallate (EGCG) on the viability, membrane properties, and zinc distribution, with and without the presence of Zn²⁺, in human prostate...Full Text Available

UK PubMed Central (United Kingdom)

Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionTyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine...Full Text Available

UK PubMed Central (United Kingdom)

The dielectrophoretic (DEP) crossover method has been applied to the detection of cell responses to toxicants. Time and dose responses of the human cultured leukemia (HL-60) line were measured...Full Text Available

UK PubMed Central (United Kingdom)

mRNA is sequestered and turned over in cytoplasmic processing bodies (PBs), which are induced by various cellular stresses. Unexpectedly, in Saccharomyces cerevisiae, mutants of the...Full Text Available

UK PubMed Central (United Kingdom)

Activation of beta-adrenergic or muscarinic acetylcholine receptors expressed in transfected cells or epidermal growth factor receptors in human keratinocytes produces 15% to 200% changes in cellular...Full Text Available

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BackgroundPrimary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the cellular and molecular levels, necessary...Full Text Available

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The cellular properties of long-term potentiation (LTP) following pairing of pre- and postsynaptic activity were examined at a known glutamatergic synapse in the leech, specifically between the pressure...Full Text Available

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Cellular cholesterol homeostasis is controlled by sterol-regulated proteolysis of membrane-bound transcription factors called sterol-regulatory element binding proteins (SREBPs). CPP32, a cysteine protease,...Full Text Available

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The cell types involved in the cellular immune response were studied with the GVH in vitro as a test system. Comparison of the activities of cells of different lymphoid organs in the...Full Text Available

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Store-operated Ca²⁺ entry (SOCE) is a ubiquitous Ca²⁺ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence...Full Text Available

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E-cadherins belong to a family of membrane-bound, cellular adhesion proteins. Their adhesive properties mainly involve the two N-terminal extracellular domains (EC1 and EC2). The junctions between these...Full Text Available

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Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO₂ represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia...Full Text Available

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The free radical theory of ageing posits that accrual of oxidative damage underlies the increased cellular, tissue and organ dysfunction and failure associated with advanced age. In support of this...Full Text Available

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In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard,...Full Text Available

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Atherosclerosis is an inflammatory process leading to enhanced cellular proliferation, apoptosis, and vasa vasorum (VV) neovascularization. While both diabetes mellitus (DM) and hypercholesterolemia...Full Text Available

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The endoplasmic reticulum (ER) is an essential cellular compartment responsible for Ca²⁺ sequestration, signaling, protein translation, folding as well as transport. Several acute...Full Text Available

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Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available

UK PubMed Central (United Kingdom)

Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain...Full Text Available

CERN Multimedia

"Force20 networks, the pioneer in building and securing reliable networks, today announced that the University of Tennessee physics department has deployed the C300 resilient switch to analyze data form CERN's Large Hadron Collider." (1/2 page)

UK PubMed Central (United Kingdom)

Many healthcare organizations utilize network "firewalls" to protect their networks from being accessed by unauthorized external entities. These same firewalls are also often configured to deny access...Full Text Available

UK PubMed Central (United Kingdom)

Reverse engineering of gene regulatory networks has been an intensively studied topic in bioinformatics since it constitutes an intermediate step from explorative to causative gene expression...Full Text Available

UK PubMed Central (United Kingdom)

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundA wide range of techniques is now available for analyzing regulatory networks. Nonetheless, most of these techniques fail to interpret large-scale transcriptional data...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGene expression profiling and the analysis of protein-protein interaction (PPI) networks may support the identification of disease bio-markers and potential drug targets....Full Text Available

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BackgroundModern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has...Full Text Available

UK PubMed Central (United Kingdom)

PURPOSE We wanted to assess computer capabilities in a primary care practice-based research network and to understand how receptive the practices were to new ideas for automation of practice...Full Text Available

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BackgroundNetwork visualization would serve as a useful first step for analysis. However, current graph layout algorithms for biological pathways are insensitive to biologically...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The effect of high-energy-density laser surface melting on the morphology and properties of a cast Ni-based superalloy containing 33 wt percent Mo and 17 wt percent W is investigated experimentally. Significant improvements in the hardness and the wear resistance in both dry and acid environments are atttributed to the elimination of segregation in the laser-treated zone, where solid solubility increases, crystalline structure becomes finer, and the fine dendritic, cellular dendritic, cellular, and plane-front solidification structures are evenly distributed.

Science.gov (United States)

... Abstract : The acousto-optic filter (AOF) is ... for large switch networks. ... FOURIER TRANSFORMATION, OPTICAL SWITCHING, SURFACE ACOUSTIC ...

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... more and better sensors to be ... all the continuously incoming data, which ... RANGE RECEIVER THERMAL CONDUCTIVITY ,# PRESSURE SENSOR ...

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... the bound (5). For a network composed of a single source-terminal pair and ... Suboptimality bounds in stochastic control: A queueing example ...

British Library Electronic Table of Contents (United Kingdom)

This article introduces the story of Yusuf al-Marzuk (1895-1957), a Kuwaiti merchant who created a thriving network in the Arabian/Persian Gulf and India. This network was part of the vast, undocumented activities of Kuwaiti merchants. They were uncovered by rare British reports. Yusuf's economic power enabled him to participate in the struggle of Kuwaiti elites to achieve political power vis-a-vis the Kuwaiti rulers, the Sabah family. This article demonstrates the importance of the trading networks with respect to the economic and political developments that shaped the region before the relatively well researched oil period.

Science.gov (United States)

... from theory to practice will be significantly reduced while intrinsically revolutionizing the approach to engineering network security architectures. ...

Science.gov (United States)

General Meeting: NASA's biggest challenge: Education ... Turn right into the Police Association Facility at the crest of the first hill. ...