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Sample records for 1st nci epi

  1. Emerging Pathogens Initiative (EPI)

    Department of Veterans Affairs — The Emerging Pathogens Initiative (EPI) database contains emerging pathogens information from the local Veterans Affairs Medical Centers (VAMCs). The EPI software...

  2. Emergency Preparedness at NCI

    Information to help prepare for an emergency. Includes resources for patients and health care providers to continue cancer care, NCI contacts for grantees, and resources to prepare and update NCI employees and contractors.

  3. NCI Contact Center

    The NCI offers free, scientifically accurate, and easy-to-understand information on a range of cancer topics in English and Spanish. Get live help from compassionate information specialists at 1-800-4-CANCER.

  4. NCI Designated Cancer Centers

    ... content 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  5. NCI Cohort Consortium Membership

    The NCI Cohort Consortium membership is international and includes investigators responsible for more than 40 high-quality cohorts who are studying large and diverse populations in more than 15 different countries.

  6. NCI Visuals Online

    NCI Visuals Online contains images from the collections of the National Cancer Institute's Office of Communications and Public Liaison, including general biomedical and science-related images, cancer-specific scientific and patient care-related images, and portraits of directors and staff of the National Cancer Institute.

  7. NCI Cohort Consortium

    The NCI Cohort Consortium is an extramural-intramural partnership formed by the National Cancer Institute to address the need for large-scale collaborations to pool the large quantity of data and biospecimens necessary to conduct a wide range of cancer studies.

  8. spinning and weaving (1st version)

    Gardiner, Ian R.

    2012-01-01

    Work for solo bass clarinet and small ensemble (9 players), duration 15 minutes, pp 45. Commissioned by the Royal Liverpool Philharmonic Society. 1st performance of 2rd section, Katherine Lacy (bass cl.), 10/10 Ensemble, conducted by Clark Rundell, Wigmore Hall, London, 5 March 2010). [1st performance of complete version, same musicians, Cornerstone, Liverpool, 25 January 2012

  9. Data Sets from Major NCI Initiaves

    The NCI Data Catalog includes links to data collections produced by major NCI initiatives and other widely used data sets, including animal models, human tumor cell lines, epidemiology data sets, genomics data sets from TCGA, TARGET, COSMIC, GSK, NCI60.

  10. Digital Standards for NCI Websites

    The Digital Standards for NCI Websites and Social Media provide developers and content managers guidance on the visual and content standards, as well as policies and procedures, in effect for National Cancer Institute (NCI) digital media – including traditional and mobile websites, as well as social and new media channels.

  11. 2008 Environmental Performance Index (EPI)

    National Aeronautics and Space Administration — The 2008 Environmental Performance Index (EPI) centers on two broad environmental protection objectives: (1) reducing environmental stresses on human health, and...

  12. NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) Trial

    NCI's gateway for information about the NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) trial, in which patients with advanced cancer are assigned to treatment arms based on the molecular profiles of their disease.

  13. Join TTC! | NCI Technology Transfer Center | TTC

    The NCI Technology Transfer Center (TTC) offers a unique opportunity for training through the NCI TTC Fellowship program. TTC also has a unit dedicated to marketing these research opportunities and their underlying technologies to potential collaborators and licensees.

  14. Competències professionals

    Torrens Ramis, Monserrat

    2013-01-01

    El treball final de grau està orientat a l'estudi de les competències professionals d'un enginyer en informàtica i sobre la formació que ha de proporcionar un pla d'estudis per poder-les desenvolupar.

  15. CDC WONDER: Population - Bridged-Race July 1st Estimates

    U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

  16. Electronic Health Records Place 1st at Indy 500

    Skip Navigation Bar Home Current Issue Past Issues EHR Electronic Health Records Place 1st at Indy 500 ... Electronic Health Records Place 1st at Indy 500 / EHR/PHR Basics / Personal, Electronic, Secure National Library of ...

  17. 1st Applied Electromagnetic International Conference

    Othman, Mohd; Aziz, Mohamad; Malek, Mohd

    2015-01-01

    In this book, experts from academia and industry present the latest advances in scientific theory relating to applied electromagnetics and examine current and emerging applications particularly within the fields of electronics, communications, and computer technology. The book is based on presentations delivered at APPEIC 2014, the 1st Applied Electromagnetic International Conference, held in Bandung, Indonesia in December 2014. The conference provided an ideal platform for researchers and specialists to deliver both theoretically and practically oriented contributions on a wide range of topics relevant to the theme of nurturing applied electromagnetics for human technology. Many novel aspects were addressed, and the contributions selected for this book highlight the relevance of advances in applied electromagnetics to a variety of industrial engineering problems and identify exciting future directions for research.

  18. Proceedings of the 1st Puerto Rico Biobanking Workshop.

    Mora, Edna; Robb, James A; Stefanoff, Gustavo; Mellado, Robert Hunter; Coppola, Domenico; Muñoz-Antonia, Teresita; Flores, Idhaliz

    2014-01-01

    The 1st Puerto Rico Biobanking Workshop took place on August 20st, 2014 in the Auditorium of the Comprehensive Cancer Center of the University of Puerto Rico, Medical Sciences Campus in San Juan Puerto Rico. The program for this 1-day, live workshop included lectures by three biobanking experts, followed by presentations from existing biobanks in Puerto Rico and audience discussion. The need for increasing biobanking expertise in Puerto Rico stems from the fact that Hispanics in general are underrepresented in the biobanks in existence in the US, which limits the research conducted specifically to understand the molecular differences in cancer cells compared to other better studied populations. In turn, this lack of information impairs the development of better diagnostic and therapeutic approaches for our population. Dr. James Robb, M.D., F.C.A.P., consulting pathologist to the National Cancer Institute (NCI) and the Office of Biorepositories and Biospecimen Research (OBBR), opened the workshop with a discussion on the basic aspects of the science of biobanking (e.g., what is a biobank; its goals and objectives; protocols and procedures) in his talk addressing the importance of banking tissues for advancing biomedical research. Next, Dr. Gustavo Stefanoff, from the Cancer Institutes Network of Latin America (RINC by its name in Spanish), explained the mission, objectives, and structure of the Network of Latin-American and Caribbean Biobanks (REBLAC by its name in Spanish), which despite limited resources and many challenges, currently accrue high quality human tissue specimens and data to support cancer research in the region. Dr. Robert Hunter-Mellado, Professor of Internal Medicine, Universidad Central del Caribe, followed with an examination of the ethical and regulatory aspects of biobanking tissues for future research, including informed consent of subjects; protection of human subjects rights; and balancing risks and benefit ratios. In the afternoon, the

  19. Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG)

    NCI established the Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group to support development of a comprehensive and interdisciplinary pharmacoepidemiology and pharmacogenomics cancer research program.

  20. Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish

    Liu, T.-A. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Bhuiyan, Shakhawat [Division of Arts and Sciences, Jarvis Christian College, Hawkins, TX 75765 (United States); Snow, Rhodora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Yasuda, Shin; Yasuda, Tomoko [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Yang, Y.-S. [Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Williams, Frederick E.; Liu, M.-Y.; Suiko, Masahito [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Carter, Glendora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Liu, M.-C. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States)], E-mail: ming.liu@utoledo.edu

    2008-08-29

    Cytosolic sulfotransferases (SULTs) constitute a family of Phase II detoxification enzymes that are involved in the protection against potentially harmful xenobiotics as well as the regulation and homeostasis of endogenous compounds. Compared with humans and rodents, the zebrafish serves as an excellent model for studying the role of SULTs in the detoxification of environmental pollutants including environmental estrogens. By searching the expressed sequence tag database, two zebrafish cDNAs encoding putative SULTs were identified. Sequence analysis indicated that these two putative zebrafish SULTs belong to the SULT1 gene family. The recombinant form of these two novel zebrafish SULTs, designated SULT1 ST7 and SULT1 ST8, were expressed using the pGEX-2TK glutathione S-transferase (GST) gene fusion system and purified from transformed BL21 (DE3) cells. Purified GST-fusion protein form of SULT1 ST7 and SULT1 ST8 exhibited strong sulfating activities toward environmental estrogens, particularly hydroxylated polychlorinated biphenyls (PCBs), among various endogenous and xenobiotic compounds tested as substrates. pH-dependence experiments showed that SULT1 ST7 and SULT1 ST8 displayed pH optima at 6.5 and 8.0, respectively. Kinetic parameters of the two enzymes in catalyzing the sulfation of catechin and chlorogenic acid as well as 3-chloro-4-biphenylol were determined. Developmental expression experiments revealed distinct patterns of expression of SULT1 ST7 and SULT1 ST8 during embryonic development and throughout the larval stage onto maturity.

  1. Pilot 2006 Environmental Performance Index (EPI)

    National Aeronautics and Space Administration — The Pilot 2006 Environmental Performance Index (EPI) centers on two broad environmental protection objectives: (1) reducing environmental stresses on human health,...

  2. Dinutuximab (Unituxin™) | NCI Technology Transfer Center | TTC

    In 2010, NCI entered into a Cooperative Research and Development Agreement (CRADA) with United Therapeutics Corp., under which the company assumed responsibility for manufacturing dinutuximab and moving it through the steps required for regulatory approval.

  3. EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

    2009-02-02

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

  4. Electronic Health Records Place 1st at Indy 500

    ... Navigation Bar Home Current Issue Past Issues EHR Electronic Health Records Place 1st at Indy 500 Past ... last May's Indy 500 had thousands of personal Electronic Health Records on hand for those attending—and ...

  5. Food Safety Should Come 1st on The 4th

    ... page: https://medlineplus.gov/news/fullstory_159697.html Food Safety Should Come 1st on the 4th Bacteria thrive ... this Fourth of July, don't forget about food safety. "Because foodborne bacteria thrive and multiply more quickly ...

  6. 1st HPV Test for Use with Preservative Fluid

    ... https://medlineplus.gov/news/fullstory_159789.html 1st HPV Test for Use With Preservative Fluid Human papillomavirus ... Food and Drug Administration has approved Roche's cobas HPV Test -- the first diagnostic to be used with ...

  7. EMSL Quarterly Highlights Report: 1st Quarter, FY08

    Showalter, Mary Ann

    2008-01-28

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  8. Epi Info™ 7

    2012-06-12

    In this podcast, Brad Myers, Director of the Division of Communication Services, talks with Asad Islam, who leads the Epi Info™ team at CDC, about Epi Info's new tools.  Created: 6/12/2012 by Office of Surveillance, Epidemiology, and Laboratory Services (OSELS).   Date Released: 1/17/2013.

  9. NCI at Frederick Employees Recognized at the 2013 NCI Director’s Awards Ceremony | Poster

    By Andrea Frydl, Contributing Writer, and Ashley DeVine, Staff Writer More than 60 NCI at Frederick government and contractor employees were recognized at the NCI Director’s Awards Ceremony on Nov. 14, held on the main NIH campus in Bethesda.

  10. EpiData: ¿el heredero natural de EpiInfo 6? EpiData: the natural heir to EpiInfo 6?

    Pedro Arias Bohigas; Jens L. Lauritsen

    2007-01-01

    EpiData es un programa informático desarrollado por la Asociación EpiData (www.epidata.dk) que, siguiendo la filosofía de EpiInfo 6, pretende ofrecer todas las ventajas de ese programa: sencillez, aplicabilidad, pocos requerimientos del sistema operativo y de los sistemas de comunicación, ampliándolas con un enfoque claro hacia lo documentación y la calidad de los datos, y las ventajas que para muchos usuarios tiene el entorno Windows®. El objetivo de esta Nota es presentar a los potenciales ...

  11. Module of External Particle Identifier (EPI)

    1977-01-01

    The EPI consisted of 4096 proportional counters 6x6 cm2, distributed in 128 layers of 32 each. It was used downstream of BEBC for the identification of fast forward secondaries by ionization measurements in the region of relativistic rise, see M. Aderholz et al., Nucl. Instr. & Methods 123 (1975) 237. The photo shows one double layer module of the EPI during the construction, see M. Aderholz et al., Nucl. Instr. & Methods 118 (1974) 419. On the left, Ivan Lehraus.

  12. Mission & Role | NCI Technology Transfer Center | TTC

    The NCI TTC serves as the focal point for implementing the Federal Technology Transfer Act to utilize patents as incentive for commercial development of technologies and to establish research collaborations and licensing among academia, federal laboratories, non-profit organizations, and industry.

  13. At NCI, Supporting the Best Science

    Yesterday, at the AACR annual meeting, Dr. Doug Lowy spoke directly to the research community about his goals as NCI Acting Director. Dr. Lowy said that he plans to continue many of the programs launched by his predecessor, Dr. Harold Varmus, and to sharp

  14. License Agreements | NCI Technology Transfer Center | TTC

    Since the government cannot engage in the development, manufacture, and sale of products, the NCI Technology Transfer Center (TTC) makes its discoveries (and discoveries from nine other NIH Institutes) available to organizations that can assist in the further development and commercialization of these basic science discoveries, to convert them into public health benefits.

  15. Characterisation of the 1st SSI purified MBL standard

    Laursen, Inga; Højrup, Peter; Houen, Gunnar;

    2008-01-01

    156.0-229.2 microg/ml). A calibrated time-resolved immuno-flourescence assay was used for stability evaluation of the MBL standard, after transfer from -80 degrees C, showing stability for at least 10 days at 25 degrees C, 14 days at 5 degrees C, and 16 weeks at -20 degrees C. CONCLUSION: The 1st SSI...

  16. Proceedings of the 1st JAERI symposium on HTGR technologies

    This report was edited as the Proceedings of the 1st JAERI Symposium on HTGR Technologies, - Design, Licensing Requirements and Supporting Technologies -, collecting the 21 papers presented in the Symposium. The 19 of the presented papers are indexed individually. (J.P.N.)

  17. 1st Scientific Researches Congress Humanity and Social Sciences

    IŞIK YILMAZ, Sultan

    2016-01-01

    Abstract. In this study, the evaluation of the 1st International Scientific Researches Congress Humanity and Social Sciences held on 19-22 May 2016 in Madrid will be mentioned.Keywords. Social Sciences, Humanity Sciences, Technology Awareness, Future Expectations, University Students, Madrid.JEL. O10, L20, L24.

  18. NCI Approves Funding Plan for NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    On June 24, 2014, the Scientific Program Leaders (SPL) of the National Cancer Institute (NCI) approved the funding plan for the NCI Community Oncology Research Program (NCORP), a national network of investigators, cancer care providers, academic institutions, and other organizations. NCORP will conduct multi-site cancer clinical trials and studies in diverse populations in community-based healthcare systems across the United States. The program will receive $93 million a year for five years. |

  19. The 1st Nordic Innovation Research Conference—Finnkampen

    Haapasalo, H. (Harri); Iskanius, P. (Päivi)

    2007-01-01

    Abstract The 1st Nordic Innovation Research PhD Conference, "Finnkampen", held in December 2006 in Oulu, Finland, focuses on a wide field from Innovation Management, Entrepreneurship to the whole field of Industrial Engineering and Management representing the specific areas of interest: regional innovation systems; technology strategy thinking and planning; product concept development, product visions, product development and process development, and product launch; evaluation and assessme...

  20. NCI at Frederick Ebola Response Team | Poster

    Editor’s note: This article was adapted from the Employee Diversity Team’s display case exhibit “Recognizing the NCI at Frederick Ebola Response Team,” in the lobby of Building 549. The Poster staff recognizes that this article does not include everyone who was involved in the response to the Ebola crisis, both at NCI at Frederick and in Africa. When the Ebola crisis broke out in 2014 in West Africa, staff members from the Frederick National Laboratory for Cancer Research responded quickly. Members of the Clinical Monitoring Research Program (CMRP) were instrumental not only in setting up the clinical trials of the vaccine in Liberia, but also in providing training, community outreach, and recruitment strategies for the trials.

  1. Power market investigation by the 1st of March 1994

    The report investigates changes in the wholesale and end user market after the enforcement of the Energy Act of the 1st January 1991 and compares to the report from the NVE of the 1st January 1993. The wholesale market: The average price for contracts is calculated to 14,2 oere/kWh for 1994 which is 8 % less than in 1993. The largest reduction of the average price is for the contracts made before the enforcement of the Energy Act of 1991 and new contracts made with new deliverers after the 1st of January 1991. The average price for renegotiated contracts is somewhat above the price for new contracts. The standard deviation for the average prices is reduced from 1993 to 1994 for all types of contracts. Hence the competition has lead to a certain equilibration of prices. Most contracts have still fixed prices. The investigation shows that after the enforcement of the Energy Act contracts of about 45 TWh are made with a new deliverer or renegotiated. This amounts to about 80 % of the contract volume and is an increase of 10 % from the last investigation. The end user market. Households: The average price to households was 14,7 oere/kWh for 1994 which is 2 % less than in 1993. The largest price reduction is on renegotiated contracts. This is connected to the fact that the average price for renegotiated contracts by the 1st of January 1993 is somewhat above the average price for old and new contracts. This picture has changed and renegotiated contracts are now more in tune with the average price for other contracts. 5,6 % of the household customers have renegotiated their contracts or made contracts with new deliverers after enforcement of the Energy Act of 1991. It is mostly the housing corporations that have received the lowest average price re negotiation. The H4-tariff is the predominant offer to the households. Business customers: The average price to these customers is of 12,6 oere/kWh for 1994 which 8 % less than in 1993. The price alteration is largest for

  2. [Granuloma Gravidarum in a 37-year-old 1st Gravida, 1st Para--A Case Report].

    Findeklee, S

    2015-10-01

    The granuloma gravidarum is a rare benign tumour with gingival origin. It occurs in circa 0.2% of pregnancies. Mostly we see an asymptomatic course of disease terminated by hormonal changes after delivery. If the granuloma is associated with complaints of the pregnant woman, for example masticational pain or recurrent bleedings, therapeutic options are conservative therapy, surgery or delivery. We report the case of a 37-year-old 1st gravida, 1st para who had an induced delivery in the 39+2 gestational week because of a symptomatic granuloma gravidarum. We saw a spontaneous remission of the granuloma within 3 months post partum. The case report underlines the importance of suitable information for pregnant women about oral hygiene and the necessity of regular dental controls during pregnancy for prophylaxis of granuloma gravidarum. PMID:26402852

  3. NCI's Transdisciplinary High Performance Scientific Data Platform

    Evans, Ben; Antony, Joseph; Bastrakova, Irina; Car, Nicholas; Cox, Simon; Druken, Kelsey; Evans, Bradley; Fraser, Ryan; Ip, Alex; Kemp, Carina; King, Edward; Minchin, Stuart; Larraondo, Pablo; Pugh, Tim; Richards, Clare; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2016-04-01

    The Australian National Computational Infrastructure (NCI) manages Earth Systems data collections sourced from several domains and organisations onto a single High Performance Data (HPD) Node to further Australia's national priority research and innovation agenda. The NCI HPD Node has rapidly established its value, currently managing over 10 PBytes of datasets from collections that span a wide range of disciplines including climate, weather, environment, geoscience, geophysics, water resources and social sciences. Importantly, in order to facilitate broad user uptake, maximise reuse and enable transdisciplinary access through software and standardised interfaces, the datasets, associated information systems and processes have been incorporated into the design and operation of a unified platform that NCI has called, the National Environmental Research Data Interoperability Platform (NERDIP). The key goal of the NERDIP is to regularise data access so that it is easily discoverable, interoperable for different domains and enabled for high performance methods. It adopts and implements international standards and data conventions, and promotes scientific integrity within a high performance computing and data analysis environment. NCI has established a rich and flexible computing environment to access to this data, through the NCI supercomputer; a private cloud that supports both domain focused virtual laboratories and in-common interactive analysis interfaces; as well as remotely through scalable data services. Data collections of this importance must be managed with careful consideration of both their current use and the needs of the end-communities, as well as its future potential use, such as transitioning to more advanced software and improved methods. It is therefore critical that the data platform is both well-managed and trusted for stable production use (including transparency and reproducibility), agile enough to incorporate new technological advances and

  4. 2003 - 2004 ACADEMIC TRAINING PROGRAMME 1st TERM

    Françoise Benz

    2003-01-01

    1st TERM 29 September to 19 December 2003 REGULAR LECTURE PROGRAMME (Renewable) Energy Policy in the EU Members States and the Accession States By D. Reiche, Free University of Berlin, D 13, 14, 15, 16, 17 October LECTURES SERIES FOR POSTGRADUATE STUDENTS Introduction to QCD By B. Webber, CERN-TH 20, 21, 22, 23, 24 October The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures.

  5. Meena -- her perspective on "EPI Plus".

    Dodge, C P

    1992-06-01

    The mean age at marriage in Bangladesh with a population of 110 million has increased from 13 to 1931 to 18 in 1992. Yet 80% of women give birth during their teens. 80% live in the countryside, only 35% complete primary school, and only 22% of women are literate (44% of men). By 1990, girls primary school attendance increased to 45% from 31% in 1970. Between 1960 and 1990 per capita calorie consumption had declined from 2300 calories/day. Maternal mortality was 600/100,000 live births. The projection of a population of 220 million people by 2025 could result in even more dire health prospects for these women. Since independence in 1971, family planning (FP) using paramedics has expanded in rural areas. Nongovernmental organizations supported urban efforts by promoting pills and condoms under the largest social marketing project. The contraceptive prevalence rate (CPR) increased to 40% by 1991, and the average number of children dropped from 7 in 1971 to 4 in 1990. The main components of child survival are breast feeding, oral rehydration therapy (ORT), and immunization. 300,000 children die annually from diarrhea, but ORT use has surged in recent years curtailing expected deaths in the wake of the 1988 and 1991 natural disasters. In 1991, immunization coverage reached 85% from under 5% in 1985. The expanded program of immunization (EPI) also integrated FP in pilot upazilas (districts) with a simultaneous increase of both CPR and EPI coverage resulting in improved child survival. There are 100,000 EPI outreaches contracting 80% of mothers with FP counseling, iron supplementation, screening risk delivery, vitamin A supplementation, oral rehydration solution distribution, and nutritional counseling. 3 phases of the classical demographic transition have taken place in Bangladesh but the population will keep increasing until stability is reached with fertility and mortality in balance that EPI and FP can help ensure. PMID:12285549

  6. Halaven® - eribulin mesylate (analog of halichondrin B) | NCI Technology Transfer Center | TTC

    Under a CRADA with NCI, Eisai Co. provided eribulin for NCI's preclinical development activities and to support NCI's Phase I clinical trials. Eisai ultimately took the product, Halaven®, to licensure.

  7. NCI Community Oncology Research Program Approved | Division of Cancer Prevention

    On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |

  8. 1st International Conference on Calcined Clays for Sustainable Concrete

    Favier, Aurélie

    2015-01-01

    This volume focuses on research and practical issues linked to Calcined Clays for Sustainable Concrete. The main subjects are geology of clays, hydration and performance of blended systems with calcined clays, alkali activated binders, economic and environmental impacts of the use of calcined clays in cement based materials. Topics addressed in this book include the influence of processing on reactivity of calcined clays, influence of clay mineralogy on reactivity, geology of clay deposits, Portland-calcined clay systems, hydration, durability, performance, Portland-calcined clay-limestone systems, hydration, durability, performance, calcined clay-alkali systems, life cycle analysis, economics and environmental impact of use of calcined clays in cement and concrete, and field applications. This book compiles the different contributions of the 1st International Conference on Calcined Clays for Sustainable Concrete, which took place in Lausanne, Switzerland, June, 23-25, 2015.The papers present the latest  res...

  9. 1st International Conference on Robot Intelligence Technology and Applications

    Matson, Eric; Myung, Hyun; Xu, Peter

    2013-01-01

    In recent years, robots have been built based on cognitive architecture which has been developed to model human cognitive ability. The cognitive architecture can be a basis for intelligence technology to generate robot intelligence. In this edited book the robot intelligence is classified into six categories: cognitive intelligence, social intelligence, behavioral intelligence, ambient intelligence, collective intelligence and genetic intelligence. This classification categorizes the intelligence of robots based on the different aspects of awareness and the ability to act deliberately as a result of such awareness. This book aims at serving researchers and practitioners with a timely dissemination of the recent progress on robot intelligence technology and its applications, based on a collection of papers presented at the 1st International Conference on Robot Intelligence Technology and Applications (RiTA), held in Gwangju, Korea, December 16-18, 2012. For a better readability, this edition has the total 101 ...

  10. 1st International Conference on Computational and Experimental Biomedical Sciences

    Jorge, RM

    2015-01-01

    This book contains the full papers presented at ICCEBS 2013 – the 1st International Conference on Computational and Experimental Biomedical Sciences, which was organized in Azores, in October 2013. The included papers present and discuss new trends in those fields, using several methods and techniques, including active shape models, constitutive models, isogeometric elements, genetic algorithms, level sets, material models, neural networks, optimization, and the finite element method, in order to address more efficiently different and timely applications involving biofluids, computer simulation, computational biomechanics, image based diagnosis, image processing and analysis, image segmentation, image registration, scaffolds, simulation, and surgical planning. The main audience for this book consists of researchers, Ph.D students, and graduate students with multidisciplinary interests related to the areas of artificial intelligence, bioengineering, biology, biomechanics, computational fluid dynamics, comput...

  11. 1st International Conference on Advancements of Medical Electronics

    Bag, Sandip; Ganguly, Karabi; Sarkar, Indranath; Biswas, Papun

    2015-01-01

    The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 1st International Conference on Advancements of Medical Electronics (ICAME2015). The conference is organized jointly by the Department of Biomedical Engineering and Electronics and Communication Engineering, JIS College of Engineering, West Bengal, India. The primary objective of the conference is to strengthen interdisciplinary research and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad got together and shared their knowledge. The book presents research articles of medical image processing & analysis, biomedical instrumentation & measurements, DSP & clinical applications, embedded systems & its applications in healthcare. The book can be referred as a tool for further research.

  12. 1st Workshop of Astronomy and Astrophysics for Students

    Napolitano, N R

    2007-01-01

    The "1st Workshop of Astronomy and Astrophysics for Students" was organized with the purpose of bringing togheter scientific Institutions involved in Astrophysical researches, of the Campania region and beyond. In this context the expression "Astronomy and Astrophysics" was used in its broadest meaning, i.e. including all topics related to the study of the Universe: the Sun and the Solar system, Stars, Galaxies, Cosmology, Astroparticles and Astronomical Technologies, with the belief that all scientific areas would benefit from interaction with related, if not strictly connected, research environments. The goal of the Workshop was to offer Students (undergraduate, graduate, PhD and Post-Docs) the opportunity to share their expertise with colleagues studying and working in other Universities and/or Research Institutes involved in research programs of astrophysical interests. At the same time the Workshop was intended to be a place were the partecipants could, possibly for the first time, promote the work done ...

  13. Migration Issues in Modularity for 1st Tier Automotive Suppliers

    James O’ Kane

    2009-02-01

    Full Text Available This research attempts to explore the challenges and issues which local automotive component suppliers face as they make the transition to cockpit module suppliers. The paper firstly provides a description of modularity and then discusses the changing supplier roles and relationships in modular outsourcing. An exploratory case study approach involving two suppliers and one OEM is then used to investigate these themes and provide some insights into the motivations and implications for local component suppliers becoming cockpit module suppliers. The paper argues that there are a number of key issues facing suppliers and OEMs in their quest for modular production and supply. These relate to local expertise, supplier management, financial risk, and on-site/off-site (proximity operations. This study sheds light on important emerging trends within automotive 1st tier/OEM relationships, in particular issues relating to changing supplier roles.

  14. 1st International Conference on Communication and Computer Engineering

    Othman, Mohd; Othman, Mohd; Rahim, Yahaya; Pee, Naim

    2015-01-01

    This book covers diverse aspects of advanced computer and communication engineering, focusing specifically on industrial and manufacturing theory and applications of electronics, communications, computing, and information technology. Experts in research, industry, and academia present the latest developments in technology, describe applications involving cutting-edge communication and computer systems, and explore likely future directions. In addition, access is offered to numerous new algorithms that assist in solving computer and communication engineering problems. The book is based on presentations delivered at ICOCOE 2014, the 1st International Conference on Communication and Computer Engineering. It will appeal to a wide range of professionals in the field, including telecommunication engineers, computer engineers and scientists, researchers, academics, and students.

  15. Bulletin de l'EPI n° 52 de décembre 1988

    Baudé, Jacques

    1988-01-01

    Sommaire. Bulletin de l'EPI (Enseignement Public et Informatique), (52), décembre 1988. 1-2. b52p001EPI, Ramis, R. (1988). Éditorial. Bulletin de l'EPI (Enseignement Public et Informatique), (52). 3. b52p003EPI (1988). Lettre de l'EPI au Président de la République. Bulletin de l'EPI (Enseignement Public et Informatique), (52). 4-5. b52p004EPI (1988). Communiqué de Presse EPI du 28-10-88. Bulletin de l'EPI (Enseignement Public et Informatique), (52). 6. b52p006EPI (1988). Nous avons lu. Bullet...

  16. Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi- and 86-epi-Diastereoisomers

    Nicolaou, K.C.; Gelin, Christine F.; Seo, Jae Hong; Huang, Zhihong; Umezawa, Taiki

    2010-01-01

    A devised synthetic strategy toward the QRSTU ring system 4 of the marine-derived biotoxin maitotoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring systems 5 and 6. The convergent route to these maitotoxin fragments involved coupling of UT and Q building blocks 9 (obtained from 2-deoxy-D-ribose) and 10 (obtained from D-ribose) followed by ring-closing metathesis to afford enol ether 8, whose elaboration to the targeted QRSTU ring system 4 required it...

  17. EpiNet : Revue électronique de l'EPI, Année 2005, n° 71-80

    Viaud, Jean-Bernard

    2005-01-01

    Archambault, J.-P., Drechsler, M. (2005). Des enseignants auto-producteurs. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2005, (71).a0501aBaudé, J. (2005). Et toujours le bidouillage. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2005, (71).a0501bEPI (2005). Communiqué EPI à propos du projet de loi d'orientation pour l'École. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2005, (71).d0501aBau...

  18. NCI at Frederick Contributes to Feds Feed Families | Poster

    Once again, NCI at Frederick participated in the annual Feds Feed Families event, which challenges federal workers to help knock out hunger with a food drive. This year, NIH collected 26,315 pounds of non-perishable goods, beating its goal of collecting 20,000 pounds. This includes over four tons of food that was collected at satellite locations, including NCI at Frederick. The food collected at NCI at Frederick was donated locally to the Frederick Rescue Mission. These donations help feed local families in need through the holiday season.

  19. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop

    none,

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: 1. Share the latest relevant knowledge among technical experts; 2. Review relevant state-of-the-art field measurement technologies and methods; 3. Review lessons learned from recent field deployments; 4. Identify synergies across different industries; 5. Identify gaps between existing and needed instrumentation capabilities; 6. Understand who are the leading experts; 7. Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  20. THEOS: The1st Thailand EO System and

    Peanvijarnpong, Chanchai

    Thailand has engaged in remote sensing satellite technological and scientific development many years since early 1980s. Thailand Landsat Station was established as a regional center of data processing and dissemination for Thai scientists for data applications. Over the years, GISTDA and Thai user community have been gaining technical experience and expertise in satellite data applications around the country such natural resources and environmental management, forest inventory, forest change detections, soil mapping, land-use and land cover mapping, crop type mapping, coastal shrimp farming, flood zone mapping, base mapping, water and drought management. The Government of Thailand realizes that remote sensing satellite technology is an important mechanism for social and economic development of the country. So the 1st Thailand Earth Observation System (THEOS) development program was approved by the Government since 2003. THEOS system is sub-synchronous satellite orbiting around the earth at 822 km. altitude same as SPOT satellites. It carries two imaging instruments; 2-m Panchromatic telescope with 22 km. swath width and 15-m resolution camera with four-multi-spectral band and 90-km swath wide. THEOS is scheduled to launch around March 2008. A number of technological and scientific activities has been implementing for Thailand and international scientific user community. Therefore THEOS is strong endorsement from the Government of Thailand on the value of remote sensing technology. This paper presents Thailand EO activities including THEOS System and its plans.

  1. Centro para la Salud Mundial (CGH) del NCI

    El Centro para la Salud Mundial (CGH) del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

  2. NCI and the Precision Medicine Initiative®

    NCI's activities related to precision medicine focuses on new and expanded precision medicine clinical trials; mechanisms to overcome drug resistance to cancer treatments; and developing a shared digital repository of precision medicine trials data.

  3. Líneas Vitales: Programas y servicios del NCI

    Artículos y videos sobre los programas y servicios del Instituto Nacional del Cáncer de la serie educativa Líneas Vitales del NCI, la cual está dirigida especialmente a poblaciones multiculturales.

  4. 2009 FRIENDS-OF-NCI-EGRP News Flashes

    A 2009 archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  5. 2011 FRIENDS-OF-NCI-EGRP News Flashes

    A 2011 archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  6. 2008 FRIENDS-OF-NCI-EGRP News Flashes

    A 2008 archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  7. 2010 FRIENDS-OF-NCI-EGRP News Flashes

    A 2010 archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  8. 2013 FRIENDS-OF-NCI-EGRP News Flashes

    An archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  9. 2012 FRIENDS-OF-NCI-EGRP News Flashes

    A 2012 archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  10. 2014 FRIENDS-OF-NCI-EGRP News Flashes

    An archive of listserv announcements sent by the Epidemiology and Genetics Research Program to FRIENDS-OF-NCI-EGRP LISTSERV subscribers to communicate information about funding opportunities, grantsmanship issues, research resources, and other relevant news.

  11. Invention Development Program Helps Nurture NCI at Frederick Technologies | Poster

    The Invention Development Fund (IDF) was piloted by the Technology Transfer Center (TTC) in 2014 to facilitate the commercial development of NCI technologies. The IDF received a second round of funding from the NCI Office of the Director and the Office of Budget and Management to establish the Invention Development Program (IDP) for fiscal year 2016. The IDP is using these funds to help advance a second set of inventions.

  12. EpiNet : Revue électronique de l'EPI, Année 2011, n° 131-140

    Archambault, Jean-Pierre

    2011-01-01

    Accès aux articles et documents dans le fichier attaché index.html. EPI, Archambault, J.-P. (2011). Éditorial : Le Google de demain. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2011, (131).a1101a Rocha, J., Muscinesi, F. (2011). Identités-femmes et software libre. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2011, (131).a1101b Bouchard, P. (2011). Information éducative. EpiNet : Revue électronique de l'EPI (Enseignement Pu...

  13. SOURCE 1ST 2.0: development and beta testing

    SOURCE 1ST 2.0 is the Industry Standard fission product release code that is being developed by Ontario Power Generation, New Brunswick Power, Hydro-Quebec, and Atomic Energy of Canada Ltd. This paper is a report on recent progress on requirement specification, code development, and module verification and validation activities. The theoretical basis for each model in the code is described in a module Software Theory Manual. The development of SOURCE IST 2.0 has required code design decisions about how to implement the software requirements. Development and module testing of the β1 release of SOURCE IST 2.0 (released in July 1999) have led to some interesting insights into fission product release modelling. The beta testing process has allowed code developers and analysts to refine the software requirements for the code. The need to verify physical reference data has guided some decisions on the code and data structure design. Examples of these design decisions are provided. Module testing, and verification and validation activities are discussed. These activities include code-targeted testing, stress testing, code inspection, comparison of code with requirements, and comparison of code results with independent algebraic, numerical, or semi-algebraic calculations. The list of isotopes to be modelled by SOURCE IST 2.0 provides an example of a subset of a reference data set. Isotopes are present on the list for a variety of reasons: personnel or public dose, equipment dose (for environmental qualification), fission rate and actinide modelling, or stable (or long-lived) targets for activation processes. To accommodate controlled changes to the isotope list, the isotope list and associated nuclear data are contained in a reference data file. The questions of multiple computing platforms, and of Year 2000 compliance have been addressed by programming rules for the code. By developing and testing modules on most of the different platforms on which the code is intended

  14. Morbidity mortality paradox of 1st generation Greek Australians.

    Kouris-Blazos, Antigone

    2002-01-01

    There is evidence in Australia that 1st generation Greek Australians (GA), despite their high prevalence of cardiovascular disease (CVD) risk factors (e.g. obesity, diabetes, hyperlipidaemia, smoking, hypertension, sedentary lifestyles) continue to display more than 35% lower mortality from CVD and overall mortality compared with the Australian-born after at least 30 years in Australia. This has been called a 'morbidity mortality paradox' or 'Greek-migrant paradox'. Retrospective data from elderly Greek migrants participating in the International Union of Nutrition Sciences Food Habits in Later Life (FHILL) study suggests that diets changed on migration due to the: (i) lack of familiar foods in the new environment; (ii) abundant and cheap animal foods (iii) memories of hunger before migration; and (iv) status ascribed to energy dense foods (animal foods, white bread and sweets) and 'plumpness' as a sign of affluence and plant foods (legumes, vegetable dishes, grainy bread) and 'thinness' as a sign of poverty. This apparently resulted in traditional foods (e.g. olive oil) being replaced with 'new' foods (e.g. butter), 'traditional' plant dishes being made more energy dense, larger serves of animal foods, sweets and fats being consumed, and increased frequency of celebratory feasts. This shift in food pattern contributed to significant weight gain in GA. Despite these potentially adverse changes, data from Greece in the 1960s (seven countries study) and from Australia in the 1990s (FHILL study) has shown that Greek migrants have continued to eat large serves of putatively protective foods (leafy vegetables, onions, garlic, tomatoes, capsicum, lemon juice, herbs, legumes, fish) prepared according to Greek cuisine (e.g. vegetables stewed in oil). Furthermore, GA were found to return to the traditional Greek food pattern with advancing years. We suspect that these factors may explain why GA have recently been found to have over double the circulating concentrations of

  15. Clinical Multishot DW-EPI Through Parallel Imaging With Considerations of Susceptibility, Motion, and Noise

    Skare, Stefan; Newbould, Rexford D.; Clayton, David B.; Albers, Gregory W; Nagle, Scott; Bammer, Roland

    2007-01-01

    Geometric distortions and poor image resolution are well known shortcomings of single-shot echo-planar imaging (ss-EPI). Yet, due to the motion immunity of ss-EPI, it remains the most common sequence for diffusion-weighted imaging (DWI). Moreover, both navigated DW interleaved EPI (iEPI) and parallel imaging (PI) methods, such as sensitivity encoding (SENSE) and generalized autocalibrating parallel acquisitions (GRAPPA), can improve the image quality in EPI. In this work, DW-EPI accelerated b...

  16. Analgesic Effects of 1st Generation Anti-histamines in Mice.

    Takahashi, Mebae; Shima, Kazuhiro; Tsuchiya, Masahiro; Hagiwara, Yoshihiro; Mizoguchi, Hirokazu; Sakurada, Shinobu; Sugawara, Shunji; Fujita, Takuo; Tadano, Takeshi; Watanabe, Makoto; Fukumoto, Satoshi; Endo, Yasuo

    2016-01-01

    Pain is sensed, transmitted, and modified by a variety of mediators and receptors. Histamine is a well-known mediator of pain. In addition to their anti-histaminic effects, the classical, or 1st generation, anti-histamines (1st AHs) possess, to various degrees, anti-muscarinic, anti-serotonergic, anti-adrenergic, and other pharmacologic effects. Although there have been attempts to use 1st AHs as analgesics and/or analgesic adjuvants, the advent of non-steroidal anti-inflammatory drugs (NSAIDs) discouraged such trials. We previously reported that in patients with temporomandibular disorders, osteoporosis, and/or osteoarthritis, the analgesic effects of certain 1st AHs (chlorpheniramine and diphenhydramine) are superior to those of the NSAIDs flurbiprofen and indomethacin. Here, we compared analgesic effects among 1st AHs and NSAIDs against responses shown by mice to intraperitoneally injected 0.7% acetic acid. Since 1st AHs are water soluble, we selected water-soluble NSAIDs. For direct comparison, drugs were intravenously injected 30 min before the above tests. Histamine-H1-receptor-deficient (H1R-KO) mice were used for evaluating H1-receptor-independent effects. The tested 1st AHs (especially cyproheptadine) displayed or tended to display analgesic effects comparable to those of NSAIDs in normal and H1R-KO mice. Our data suggest that the anti-serotonergic and/or anti-adrenergic effects of 1st AHs make important contributions to their analgesic effects. Moreover, combination of a 1st AH with an NSAID (cyclooxygenase-1 inhibitor) produced remarkably potent analgesic effects. We propose that a 1st AH, by itself or in combination with a cyclooxygenase-1 inhibitor, should undergo testing to evaluate its usefulness in analgesia. PMID:27040636

  17. Bulletin de l'EPI n° 44 de décembre 1986

    Pélisset, Émilien

    1986-01-01

    Sommaire. Bulletin de l'EPI (Enseignement Public et Informatique), (44), décembre 1986. 1-2. b44p001EPI, Pélisset, É. (1986). Éditorial. Bulletin de l'EPI (Enseignement Public et Informatique), (44). 3-4. b44p003EPI (1986). Manifeste de l'EPI, pour un développement pertinent et efficace de l'informatique dans l'enseignement (Nov. 1985). Bulletin de l'EPI (Enseignement Public et Informatique), (44). 5-8. b44p005EPI (1986). Nous avons lu. Bulletin de l'EPI (Enseignement Public et Informatique),...

  18. Comparison of FSE and EPI with brain MR imaging

    To compare the usefulness of echo-planar imaging(EPI) and fast spin-echo(FSE) in routine brain MR imaging. Twenty-five patients with various intracranial diseases were prospectively examined with T2-weighted MR imaging on a 1.5T unit using FSE, spin echo single-shot EPI(SS-EPI) and multi-shot EPI(MS-EPI) techniques. For qualitative assessment, overall image quality, discrimination between cortical gray-white matter and between basal ganglia-white matter, lesion conspicuity, image distortion and artifacts(motion, ghost, flow, and susceptibility) were all evaluated using a subjective scoring system ranging from 1 to 4 (1 for the worst and 4 for the best). For quantitative assessment, contrast and contrast-to-noise ratio(CNR) were calculated for cortical gray-white matter, basal ganglia-white matter, and lesion-white matter. Overall image quality, discrimination between cortical gray-white matter, basal ganglia-white matter, and lesion-white matter, lesion conspicuity, image distortion and susceptibility artifacts showed the highest value in FSE and the lowest in SS-EPI. Motion artifacts were seen only in FSE, while flow and ghost artifacts were most commonly seen in SS-EPI. Contrast and CNR of anatomical and pathologic structures showed the highest value in FSE, especially for cortical gray-white matter and basal ganglia-white matter. With regard to overall image quality, image distortion, susceptibility artifacts, contrast and CNR, EPI is far inferior to FSE. In routine brain MR imaging., the usefulness of EPI techniques would therefore be very limited

  19. SULFATE RESISTANCE MECHANISM OF HIGH-PERFORMANCE CONCRETE CONTAINING NCI

    1999-01-01

    It is found that the incorporation of Nitrite Corrosion Inhibitor (NCI) greatly weakens the resistance of mixtures to sulfate attack.To study the mechanism of this phenomenon,in this paper,the influence of NCI additionon on the cement paste and microstructure change of high performance concrete specimens is studied by means of quantitative XRD,SEM tests.The results demonstrate that the incorporation of NCI accelerates the formation of calcium hydroxide and ettringite crystals,and weakens the pore refinement effect caused by the secondary hydration reaction of fly ash and microsilica.At the age up to one year,the relative crystal quantity in mixture containing NCI is always higher than that in control mixture.The reasons for the degradation in sulfate resisitance of mixtures may be attributed to the increase and stability of the calcium hydroxide and ettringite crystals formed and the weakening of secondary hydration reaction.Based on the results,conclusion can be drawn that NCI should be used cautiously in practical engineering where high resistance to sulfate attack is required.

  20. Auditing the NCI Thesaurus with Semantic Web Technologies

    Mougin, Fleur; Bodenreider, Olivier

    2008-01-01

    Auditing biomedical terminologies often results in the identification of inconsistencies and thus helps to improve their quality. In this paper, we present a method based on Semantic Web technologies for auditing biomedical terminologies and apply it to the NCI thesaurus. We stored the NCI thesaurus concepts and their properties in an RDF triple store. By querying this store, we assessed the consistency of both hierarchical and associative relations from the NCI thesaurus among themselves and with corresponding relations in the UMLS Semantic Network. We show that the consistency is better for associative relations than for hierarchical relations. Causes for inconsistency and benefits from using Semantic Web technologies for auditing purposes are discussed. PMID:18999265

  1. Software EpiData - Applications for Needs of Biotechnological Processes

    Ljakova K.

    2007-12-01

    Full Text Available EpiData (free software for entering and documenting data is presented. Some aspect of this software is shown for needs of database system (DB and information systems (IS that can be used in bioprocess system.

  2. Software EpiData - Applications for Needs of Biotechnological Processes

    Ljakova K.

    2007-01-01

    EpiData (free software for entering and documenting data) is presented. Some aspect of this software is shown for needs of database system (DB) and information systems (IS) that can be used in bioprocess system.

  3. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  4. 77 FR 22574 - Filing Dates for the Washington Special Election In the 1st Congressional District

    2012-04-16

    ... elections on August 7, 2012, and November 6, 2012, to fill the U.S. House seat in the 1st Congressional... filed a report, the first report must cover all activity that occurred before the committee...

  5. 75 FR 12544 - Filing Dates for the Hawaii Special Election In the 1st Congressional District

    2010-03-16

    ... General Election on May 22, 2010, to fill the U.S. House seat in the 1st Congressional District vacated by... filed. If the committee is new and has not previously filed a report, the first report must cover...

  6. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2015

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2015. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  7. Woman Who Had 1st U.S. Uterus Transplant Loses the Organ Due to Complication

    ... 157677.html Woman Who Had 1st U.S. Uterus Transplant Loses the Organ Due to Complication Doctors at ... statement. "There is a known risk in solid organ transplantation that the transplanted organ may have to be ...

  8. The Effect of Foot Structure on 1st Metatarsophalangeal Joint Flexibility and Hallucal Loading

    Rao, Smita; Song, Jinsup; Kraszewski, Andrew; Backus, Sherry; Ellis, Scott J.; Deland, Jonathan T.; Hillstrom, Howard J

    2011-01-01

    The purpose of our study was to examine 1st metatarsophalangeal (MTP) joint motion and flexibility and plantar loads in individuals with high, normal and low arch foot structure. Asymptomatic individuals (n=61), with high, normal and low arches participated in this study. Foot structure was quantified using malleolar valgus index (MVI) and arch height index (AHI). First MTP joint flexibility was measured using a specially constructed jig. Peak pressure under the hallux, 1st and 2nd metatarsal...

  9. 78 FR 27974 - Proposed Collection; 60-Day Comment Request: National Cancer Institute (NCI) Alliance for...

    2013-05-13

    ... Cancer Institute (NCI) Alliance for Nanotechnology in Cancer Platform Partnership Scientific Progress... Partnerships (CNPP) awarded by the National Cancer Institute (NCI). The CNPPs are part of the Alliance for... trans-Alliance collaboration, scientific milestones, progress towards clinical translation...

  10. File list: ALL.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

    Full Text Available ALL.Lar.05.AllAg.1st_instar dm3 All antigens Larvae 1st instar SRX013088,SRX013009,...SRX013064,SRX013044,SRX013072,SRX013055,SRX013097,SRX013056 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.05.AllAg.1st_instar.bed ...

  11. File list: ALL.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

    Full Text Available ALL.Lar.50.AllAg.1st_instar dm3 All antigens Larvae 1st instar SRX013009,SRX013072,...SRX013088,SRX013044,SRX013064,SRX013097,SRX013056,SRX013055 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.50.AllAg.1st_instar.bed ...

  12. File list: ALL.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

    Full Text Available ALL.Lar.10.AllAg.1st_instar dm3 All antigens Larvae 1st instar SRX013088,SRX013064,...SRX013044,SRX013009,SRX013072,SRX013097,SRX013055,SRX013056 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.10.AllAg.1st_instar.bed ...

  13. File list: ALL.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

    Full Text Available ALL.Lar.20.AllAg.1st_instar dm3 All antigens Larvae 1st instar SRX013009,SRX013072,...SRX013088,SRX013044,SRX013064,SRX013097,SRX013055,SRX013056 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.20.AllAg.1st_instar.bed ...

  14. Centros oncológicos designados por el NCI

    El programa de centros oncológicos designados por el Instituto Nacional del Cáncer (NCI) reconoce a los centros de todo el país que cumplen con rigurosos criterios para participar en proyectos avanzados de primer nivel para la investigación multidisciplinaria del cáncer.

  15. NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.

  16. Creating Start-up Companies around NCI Inventions | Poster

    By Karen Surabian, Thomas Stackhouse, and Rose Freel, Contributing Writers, and Rosemarie Truman, Guest Writer The National Cancer Institute (NCI), led by the Technology Transfer Center (TTC),  the Avon Foundation, and The Center for Advancing Innovation have partnered to create a “first-of-a-kind” Breast Cancer Start-up Challenge.

  17. A Comparative Study of Epi-up and Epi-Down Bonding of High Power 980 nm Single-Mode Semiconductor Lasers

    Martin; Hai; Hu; Lawrence; C; Hughes; Hong; Ky; Nguyen; Catherine; G.; Caneau; Chung-En; Zah

    2003-01-01

    Epi-up and epi-down bonding of high power 980nm lasers have been studied in terms of bonding process, thermal behavior, optical performances, thermal stress effects and long-term laser reliability. We demonstrated that epi-down bonding can offer lower thermal resistance and improved optical performances without significantly degrading the long-term laser reliability.

  18. A Comparative Study of Epi-up and Epi-Down Bonding of High Power 980 nm Single-Mode Semiconductor Lasers

    Xingsheng Liu; Martin Hai Hu; Lawrence C Hughes; Hong Ky Nguyen; Catherine G. Caneau; Chung-En Zah

    2003-01-01

    Epi-up and epi-down bonding of high power 980nm lasers have been studied in terms of bonding process, thermal behavior, optical performances, thermal stress effects and long-term laser reliability. We demonstrated that epi-down bonding can offer lower thermal resistance and improved optical performances without significantly degrading the longterm laser reliability.

  19. EpiNet : Revue électronique de l'EPI, Année 2010, n° 121-130

    Archambault, Jean-Pierre

    2010-01-01

    Accès aux articles et documents dans le fichier attaché index.html. EPI, Archambault, J.-P. (2010). Éditorial : Enseignement de l'informatique, en France et ailleurs. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2010, (121). a1001a Archambault, J.-P. (2010). Économie de l'immatériel et logiciels libres. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2010, (121). a1001b Fayon, D. (2010). Vers l'enseignement d'une disciplin...

  20. EpiNet : Revue électronique de l'EPI, Année 2012, n° 141-150

    Archambault, Jean-Pierre

    2012-01-01

    Accès aux articles et documents dans le fichier attaché index.html. EPI, Archambault, J.-P. (2012). Éditorial : Une commission de l'Académie des Sciences sur l'enseignement de l'informatique. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2012, (141). a1201a Archambault, J.-P. (2012). Au bout de dix ans de pratique du B2i, nous constatons un échec. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2012, (141). a1201b Karsenti, ...

  1. Synthesis of 7,8-epi-Valtrate from (+)-Genipin

    Oh, Sangtae; Kwon, Daeho; Shin, WoonSeob; Ham, Jungyeob; Lee, Seokjoon [Kwandong Univ. College of Medicine, Gangneung (Korea, Republic of)

    2012-12-15

    In conclusion, we synthesized 7,8-epi-valtrate (6) from (+)-genipin (8). Although final product 6 has the opposite stereochemistry at C-7 and 8 compared to natural valtrate (5), this is the first synthesis of a diene-type valepotriate epimeric structure by an efficient synthetic pathway. We screened the compounds for proliferation inhibition of various cancer cell lines and HUVEC and discovered 7,8-epi-valtrate (6) and its synthetic intermediates showed strong inhibitory activity; these results will be published elsewhere.

  2. Ultrafast MR imaging with EPI of organs undergoing nonperiodic motion

    Conventional MR imaging employing repetitive data acquisition is susceptible to motion artifacts. Gating overcomes periodic motion effects. Nonperiodic motion, as encountered in the gastronintestinal tract, cardiac arrhythmias, unsedated children, and fetal imaging, thwarts conventional MR imaging. The EPI derivatives BEST and MBEST create a complex 128 x 128-pixel image in 64 msec and 128 msec, respectively, freezing motion almost completely. Sequentially recorded gastrointestinal-tract images allow quantitative evaluation of gastric and gut motility. Cardiac morphology, movement, and blood flow patterns in valvular heart disease have been depicted during atrial fibrillation. Selected clinical results with accompanying technical details illustrate the scope of EPI as a distinctive imaging modality

  3. NCI Updates Tobacco Policies Following Re-accreditation | Poster

    This year, NCI was re-accredited as one of nearly 200 CEO Cancer Gold Standard employers across the United States. According to its website, “the CEO Cancer Gold Standard provides a framework for employers to have a healthier workplace by focusing on cancer risk reduction, early detection, and access to clinical trials and high-quality care.”  As part of this re-accreditation, NCI has updated its Tobacco-Free Policy. Part of this policy includes posting signs around campus reminding visitors and staff that NCI’s campus is tobacco-free. Therefore, the use of all tobacco products is prohibited. This includes cigarettes, cigars, pipes, e-cigarettes, and smokeless tobacco.

  4. Monitoring North Korea Explosions: Status and Result of 1st and 2nd Tests (Invited)

    Chi, H.; Lee, H.; Shin, J.; Park, J.; Sheen, D.; Kim, G.; Che, I.; Lim, I.; Kim, T.

    2009-12-01

    Through data exchanging with China, Russia and Japan, KIGAM could monitor North Korea explosion tests in near real time with azimuthal full coverage from the test site. Except for the East Sea (Japan Sea) side, the seismic stations are distributed uniformly along the boundaries of North Korea and adjacent countries, and only stations with the distance of 200 to 550 Km from the test site were considered. Irrespective of azimuthal directions of stations from the test site, the conventional discrimination, Pn/Lg spectral ratio clearly showed that both tests were explosion. But mb-Ms discrimination did not show apparently the known pattern of explosion for both tests. Body wave magnitude, mb(Pn) of 2nd test, which was evaluated as 4.5 by KIGAM, varies with directional location of stations widely from 4.1 to 5.2. The magnitude obtained from Lg, mb(Lg), showed narrow variation between 4.3 to 4.7 with the average of 4.5. In the case of 1st test, both mb(Pn) and mb(Lg) showed equivalently large variation with directional station location. The error ellipses of epicentral determination of test site for 1st and 2nd tests showed almost identical pattern if they were separately calculated with the same configuration of stations. But the combined use of 1st and 2nd test data showed that 2nd test site was moved approximately 2 Km westward from 1st site. The cut-off frequencies of P wave of 1st and 2nd tests showed no or negligible difference even though the estimated yield of 2nd test were much larger than that of 1st one. The ratio of 1st and 2nd P-wave amplitudes showed from 2 to 3.1 times. Correspondingly the estimated energy or yield were ranged from 4 to roughly 10 times. KIGAM evaluated the yield of 2nd test were 8 times in the average larger than that of 1st one.

  5. NCI Alliance for Nanotechnology in Cancer - Tutorials and Seminar Series

    View details about tutorials and seminars hosted by Alliance members and members of the cancer research community. These events provide a forum for sharing innovative perspectives on research and development efforts in the field of nanotechnology and their application to cancer diagnosis, treatment, and prevention. Also visit the Event Listing section to find scientific meetings and events where NCI Alliance for Nanotechnology in Cancer leaders and members are participating.

  6. Global Proteome Analysis of the NCI-60 Cell Line Panel

    Amin Moghaddas Gholami

    2013-08-01

    Full Text Available The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we present a quantitative proteome and kinome profile of the NCI-60 panel covering, in total, 10,350 proteins (including 375 protein kinases and including a core cancer proteome of 5,578 proteins that were consistently quantified across all tissue types. Bioinformatic analysis revealed strong cell line clusters according to tissue type and disclosed hundreds of differentially regulated proteins representing potential biomarkers for numerous tumor properties. Integration with public transcriptome data showed considerable similarity between mRNA and protein expression. Modeling of proteome and drug-response profiles for 108 FDA-approved drugs identified known and potential protein markers for drug sensitivity and resistance. To enable community access to this unique resource, we incorporated it into a public database for comparative and integrative analysis (http://wzw.tum.de/proteomics/nci60.

  7. Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy.

    Bock, Christoph; Von Kuster, Greg; Halachev, Konstantin; Taylor, James; Nekrutenko, Anton; Lengauer, Thomas

    2010-01-01

    Modern life sciences are becoming increasingly data intensive, posing a significant challenge for most researchers and shifting the bottleneck of scientific discovery from data generation to data analysis. As a result, progress in genome research is increasingly impeded by bioinformatic hurdles. A new generation of powerful and easy-to-use genome analysis tools has been developed to address this issue, enabling biologists to perform complex bioinformatic analyses online - without having to learn a programming language or downloading and manually processing large datasets. In this tutorial paper, we describe the use of EpiGRAPH (http://epigraph.mpi-inf.mpg.de/) and Galaxy (http://galaxyproject.org/) for genome and epigenome analysis, and we illustrate how these two web services work together to identify epigenetic modifications that are characteristics of highly polymorphic (SNP-rich) promoters. This paper is supplemented with video tutorials (http://tinyurl.com/yc5xkqq), which provide a step-by-step guide through each example analysis. PMID:20238087

  8. Maneig farmacològic del dolor agut a urgències. Compendi d'evidències

    Basurto Oña, Xavier

    2015-01-01

    Antecedents La cefalàlgia per punció dural i el dolor abdominal de la pancreatitis aguda són dues de les entitats que cursen amb dolor agut presents als serveis d’urgències. Amb excessiva freqüència el maneig del dolor a urgències no és prou satisfactori per al pacient i una de les possibles raons és la manca de coneixement científic existent a mans dels actors implicats. Mètodes S'han portat a terme tres revisions sistemàtiques seguint la metodologia Cochrane amb l'objectiu d'identi...

  9. Total Synthesis of (±)-7-epi-Nemorosone

    Zhang, Qiang; Porco, John A.

    2012-01-01

    A concise total synthesis of (±)-7-epi-nemorosone is reported. Our synthetic approach establishes a viable route to polycyclic polyprenylated acylphloroglucinol natural products (PPAP’s) bearing a C-7 endo prenyl sidechain. Key steps include retro-aldol-vinyl cerium addition to a hydroxy adamantane core scaffold and palladium-mediated deoxygenation. PMID:22449198

  10. A Novel Synthesis of (-)-10-epi-α-Cyperone

    Li Jing FANG; Jin Chun CHEN; Guo Jun ZHENG; Yu Kun GUAN; Yu Lin LI

    2004-01-01

    An alternative route for the synthesis of (-)-10-epi-α-cyperone 1 starting from (+)- dihydrocarvone 2 is described by using an asymmetric Michael addition as a key step. The route features more efficiently and can be performed in large scale.

  11. EpiJSON: A unified data-format for epidemiology.

    Finnie, Thomas J R; South, Andy; Bento, Ana; Sherrard-Smith, Ellie; Jombart, Thibaut

    2016-06-01

    Epidemiology relies on data but the divergent ways data are recorded and transferred, both within and between outbreaks, and the expanding range of data-types are creating an increasingly complex problem for the discipline. There is a need for a consistent, interpretable and precise way to transfer data while maintaining its fidelity. We introduce 'EpiJSON', a new, flexible, and standards-compliant format for the interchange of epidemiological data using JavaScript Object Notation. This format is designed to enable the widest range of epidemiological data to be unambiguously held and transferred between people, software and institutions. In this paper, we provide a full description of the format and a discussion of the design decisions made. We introduce a schema enabling automatic checks of the validity of data stored as EpiJSON, which can serve as a basis for the development of additional tools. In addition, we also present the R package 'repijson' which provides conversion tools between this format, line-list data and pre-existing analysis tools. An example is given to illustrate how EpiJSON can be used to store line list data. EpiJSON, designed around modern standards for interchange of information on the internet, is simple to implement, read and check. As such, it provides an ideal new standard for epidemiological, and other, data transfer to the fast-growing open-source platform for the analysis of disease outbreaks. PMID:27266846

  12. epi-Aszonalenins A, B, and C from Aspergillus novofumigatus

    Rank, Christian; Phipps, Richard Kerry; Harris, Pernille;

    2006-01-01

    Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis ...

  13. Collaboration Opportunities with the Cancer Human Biobank (caHUB) at NCI | NCI Technology Transfer Center | TTC

    The Biorepositories and Biospecimen Research Branch (BBRB) at the National Cancer Institute has developed the Cancer Human Biobank (caHUB), which is a unique infrastructure for collecting biospecimens for the purpose of conducting biospecimen research. Biospecimens from the BPV program will be made available to collaborators with the capability to perform molecular analysis as part of a collaborative research agreement with the NCI-BBRB.

  14. Perspective through the 1st class innovation award-innovation in the key materials

    2006-01-01

    @@ Directed by Prof.Litong Zhang (Member of CAS)from Northwestern Polytechnical University, the project on the topic of ceramic matrix composite, which sustains high temperature, resists oxidization, and has a long lifetime,achieved the 1st class National Technology Innovation Award in 2004.

  15. 76 FR 51366 - Filing Dates for the Oregon Special Election in the 1st Congressional District

    2011-08-18

    ... information on these requirements, see Federal Register Notice 2009-03, 74 FR 7285 (February 17, 2009... November 8, 2011, and January 31, 2012, to fill the U.S. House seat in the 1st Congressional District... forms: One form to cover 2011 activity, labeled as the Year-End Report; and the other form to cover...

  16. 78 FR 51189 - Filing Dates for the Alabama Special Elections in the 1st Congressional District

    2013-08-20

    ... elections to fill the U.S. House seat in the 1st Congressional District vacated by Representative Jo Bonner... forms. One form to cover 2013 activity, labeled as the Year- End Report; and the other form to cover... committee is new and has not previously filed a report, the first report must cover all activity...

  17. Perceptual Narrowing of Linguistic Sign Occurs in the 1st Year of Life

    Palmer, Stephanie Baker; Fais, Laurel; Golinkoff, Roberta Michnick; Werker, Janet F.

    2012-01-01

    Over their 1st year of life, infants' "universal" perception of the sounds of language narrows to encompass only those contrasts made in their native language (J. F. Werker & R. C. Tees, 1984). This research tested 40 infants in an eyetracking paradigm and showed that this pattern also holds for infants exposed to seen language--American Sign…

  18. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    Stahel, R; Thatcher, N; Früh, M;

    2011-01-01

    The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference, the...

  19. Complex brackets and balanced complex 1st-order difference polynomials in 4-dimensional Minkowski space

    2008-01-01

    This paper investigates complex brackets and balanced complex 1st-order di?erence (BCD) polynomials. Then we propose an algorithm of O(n log n) complexity to check the equality of brackets. It substitutes exponential algorithms before. Also, BCD polynomials have some usages in geometric calculation.

  20. Requirement of copper for 1st-log growth of the yeast Saccharomyces cerevisiae

    Como, S.A.; Valerio, V.; Nickless, S.; Connelly, J.L.

    1986-05-01

    Routine evaluation of the role of copper (Cu) in the growth of various mutants of the yeast Saccharomyces Cerevisiae disclosed an unexpected effect of Cu on the fermentative first-log growth. The authors subsequent studies are attempting to ascertain the nature and significance of this observation. Cells are grown on glucose in a supplemented minimal media at 29/sup 0/C for 48-72 hrs. using New Brunswick incubator shaking at 200 rpm. Cu concentration was varied by addition of Cu salts or bathocuproine disulfonate (BC), a highly specific Cu chelator. Samples were removed periodically from flasks and dry weights were determined. Growth curve plots of normal yeasts grown in the presence of 1mM to 38mM Cu showed little variation in the expected 1st log; diauxi; 2nd log; stationary phase picture. However, in the presence of BC growth rate in the 1st log was significantly slowed and as expected 2nd log growth was essentially stopped. The low 1st log growth rate could be titrated to normal (+Cu) levels by increments of added Cu but not by added iron. The effect was not seen when Rho-minus strains were used nor when growth was followed under anaerobic conditions. Results to date implicate a mitochondrial protein, oxygen and copper in the 1st log growth of S Cerevisiae. The character of the protein agent and the possible contribution of cytochrome oxidase activity to the lst log growth are being evaluated.

  1. Proceedings of the 1st conference on nuclear structure data evaluation

    The 1st Conference on Nuclear Structure Data Evaluation was organized by the Isotopes Project of the Lawrence Berkeley Laboratory in order to encourage the open discussion of the scientific aspects of ENSDF production and usage. Summaries of the roundtable discussion sessions, abstracts of the presented papers, and additional contributed papers are contained in these Proceedings

  2. NCI Scientists Awarded National Medal of Technology and Innovation by President Obama | Poster

    Two NCI scientists received the National Medal of Technology and Innovation, the nation’s highest honor for technological achievement. The award was announced by President Obama in October. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO), Center for Cancer Research, NCI, and Douglas Lowy, M.D., also from LCO and NCI deputy director, received their medals at a White House ceremony on Nov. 20.

  3. Regional Observations of North Korea Explosions: 1st and 2nd Tests

    Chi, Heon Cheol; Shin, Jin Soo; Lee, Hee-Il; Park, Jung Ho; Sheen, Dong-Hoon; Kim, Geunyoung; Kim, Tea Sung; Che, Il-Young; Lim, In-Seub

    2010-05-01

    Through data exchanging with China, Russia and Japan, KIGAM could monitor North Korea explosion tests in near real time with azimuthally full coverage from the test site. Except for the East Sea (Japan Sea) side, the seismic stations are distributed uniformly along the boundaries of North Korea and adjacent countries. The error ellipses of epicentral determination of test site for 1st and 2nd tests showed almost identical pattern if they were separately calculated with the same configuration of stations. But the combined use of the 1st and the 2nd test data showed that the 2nd test site was moved approximately 2 Km westward from 1st site. The Pn/Lg spectral ratio clearly discriminate these events from two nearby natural earthquakes above 4 Hz. Full moment tensor inversion also indicate the 2nd test had a very large isotropic component. But mb-Ms discrimination, which has been considered one of the most reliable discriminants for separating explosions and earthquakes, did not show apparently the known pattern of explosion for both tests. Body wave magnitude, mb(Pn) of the 2nd test, which was evaluated as 4.5 by KIGAM, varies with directional location of stations widely from 4.1 to 5.2. The magnitude obtained from Lg, mb(Lg), showed narrow variation between 4.3 to 4.7 with the average of 4.5. In the case of both 1st and 2nd tests, both mb(Pn) and mb(Lg) showed equivalently large variation with directional station location. These variations are mainly due to lateral variation of crustal structures surrounding the test site. Remarkably mb(Lg) showed very linear relationship with mb(Pn). By considering attenuation characteristics according to the propagation path, the variations could be effectively reduced. The cut-off frequencies of P wave of both tests showed no or negligible difference even though the estimated yield of the 2nd test were much larger than that of the 1st one. The ratio of P-wave amplitudes of two tests showed from 2 to 3.1 times. Correspondingly the

  4. EpiNet : Revue électronique de l'EPI, Année 2002, n° 46-51

    Viaud, Jean-Bernard

    2002-01-01

    Januzec, P. (2002). Serveurs de courrier liste, serveurs pop, smtp. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), janv. 2002, (46).e46p03Moatti D. (2002). Signe authentique, signe numérique, la signature électronique. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), janv. 2002, (46).e46p04Zerhane, R., Janati-Idrissi, R., Khaldi, M., Blaghen, M., Talbi, M. (2002). Immuno-logi : hypermédia pour l'enseignement et l'apprentissage de l'immunol...

  5. Before You Collaborate, You Should Partner with NCI TTC | Poster

    By Karen Surabian, Thomas Stackhouse, and Jeffrey W. Thomas, Contributing Writers As the fall and winter seasons progress, you may be attending more scientific conferences, where you may find a number of opportunities for research collaborations. To assist your lab in reaching its research goals through collaborations, the staff of the National Cancer Institute Technology Transfer Center (NCI TTC) can guide you through a tool box of agreements you may need for protecting your intellectual property (IP) and effectively managing your collaboration. 

  6. Isoprostane 8-epi-prostaglandin F2 alpha is a potent contractor of human peripheral lymphatics.

    Sinzinger, H; Oguogho, A; Kaliman, J

    1997-09-01

    Isoprostanes are products of free radical-catalyzed peroxidation and 8-epi-prostaglandin (PG) F2 alpha is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF2 alpha stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE1, 8-epi-PGE2) had only limited lymphatic contractile potency. These data suggest a potentially relevant role for epi-8-PGF2 alpha in facilitating lymph transport especially in conditions of inflammation. PMID:9313207

  7. Revue de l'EPI n° 104 de décembre 2001

    Viaud, Jean-Bernard

    2001-01-01

    Sommaire. Revue de l'EPI (Enseignement Public et Informatique), (104), décembre 2001. 2-3. ba4p002EPI (2001). Éditorial. Revue de l'EPI (Enseignement Public et Informatique), (104). 5-6. ba4p005Pélisset, É. (2001). Enseigner autrement avec l'informatique. Revue de l'EPI (Enseignement Public et Informatique), (104). 11-14. ba4p011Cousin, A. (2001). Apprentissage et pédagogie. Revue de l'EPI (Enseignement Public et Informatique), (104). 15-24. ba4p015Chevènement, J.-P., M.E.N. (2001). Orientati...

  8. Revue de l'EPI n° 101 de mars 2001

    Viaud, Jean-Bernard

    2001-01-01

    Sommaire. Revue de l'EPI (Enseignement Public et Informatique), (101), mars 2001. 2-3. ba1p002EPI, Viaud, J.-B. (2001). Éditorial. Revue de l'EPI (Enseignement Public et Informatique), (101). 5. ba1p005Becquelin, G., M.E.N. (2001). Qu'apprend-t-on avec les TICE ? Assises Internationales Poitiers 2000. Revue de l'EPI (Enseignement Public et Informatique), (101). 19-23. ba1p019Lang, J., M.E.N. (2001). Rénovation de la formation des enseignants en IUFM. Revue de l'EPI (Enseignement Public et Inf...

  9. EpiJSON: A unified data-format for epidemiology

    Thomas J.R. Finnie; Andy South; Ana Bento; Ellie Sherrard-Smith; Thibaut Jombart

    2016-01-01

    Epidemiology relies on data but the divergent ways data are recorded and transferred, both within and between outbreaks, and the expanding range of data-types are creating an increasingly complex problem for the discipline. There is a need for a consistent, interpretable and precise way to transfer data while maintaining its fidelity. We introduce ‘EpiJSON’, a new, flexible, and standards-compliant format for the interchange of epidemiological data using JavaScript Object Notation. This forma...

  10. Epi4K: Gene discovery in 4,000 genomes

    ,

    2012-01-01

    A major challenge in epilepsy research is to unravel the complex genetic mechanisms underlying both common and rare forms of epilepsy, as well as the genetic determinants of response to treatment. To accelerate progress in this area, the National Institute of Neurological Disorders and Stroke (NINDS) recently offered funding for the creation of a “Center without Walls” to focus on the genetics of human epilepsy. This article describes Epi4K, the collaborative study supported through this gran...

  11. fMRI of the motor speech center using EPI

    The purpose of this study is to evaluate the feasibility of functional MR imaging (fMRI) using the echo planar imaging (EPI) technique to map the motor speech center and to provide the basic data for motor speech fMRI during internal word generations. This study involved ten young, healthy, right-handed volunteers (M:F=8:2; age: 21-27); a 1.5T whole body scanner with multislice EPI was used. Brain activation was mapped using gradient echo single shot EPI (TR/TE of 3000/40, slice numbers 6, slice thicknesses mm, no interslice gap, matrix numbers 128 x 128, and FOV 30 x 30). The paradigm consisted of a series of alternating rest and activation tasks, repeated eight times. During the rest task, each of ten Korean nouns composed of two to four syllables was shown continuously every 3 seconds. The subjects were required to see the words but not to generate speech, whereas during the activation task, they were asked to internally generate as many words as possible from each of ten non-concrete one-syllabled Korean letters shown on the screen every 3 seconds. During an eight-minute period, a total of 960 axial images were acquired in each subject. Data were analyzed using the Z-score (p<0.05), and following color processing, the activated signals were overlapped on T1-weighted images. The location of the activated area, mean activated signal intensity were evaluated. The results of this study indicate that in most subjects, fMRI using EPI can effectively map the motor speech center. The data obtained may be useful for the clinical application of fMRI. (author). 34 refs., 3 tabs., 5 figs

  12. Proceedings of the 1st CIRP Seminar on Micro and Nano Technology

    Hansen, Hans Nørgaard; Alting, Leo

    2003-01-01

    The present Proceedings of the 1st International CIRP Seminar on Micro and Nano Technology is the result of a CIRP initiative taken by the Working Group on Micro/Nano Technology established in 2002. The CIRP initiative is a recognition of the large potentials that micro/nano technology has...... in improving/enhancing many of the existing products and in forming the basis of a long range of new next generation of products. Micro and nano technology are common phrases used to describe phenomena, components, products etc. related to small dimensions, usually based on functioning principles...... accessible to a large group of customers. Therefore, product development and manufacture is very essential. Therefore this 1st CIRP Seminar represents an important milestone for design and industrial manufacture of products based on micro and nano technology. The Proceedings cover mostly new, interesting...

  13. Idaho National Laboratory Quarterly Performance Analysis - 1st Quarter FY2015

    Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (27 from the 1St Qtr FY-15 and 46 from the prior three reporting quarters), as well as 38 other issue reports (including nine not reportable events and Significant Category A and B conditions reported during the1st Qtr FY-15) identified at INL during the past 12 months.

  14. Perception of 1 st year medical students towards career choices and specialty of psychiatry

    Suneet Kumar Upadhyaya; Raval, Chintan M.

    2015-01-01

    Background: Shortage of psychiatrists is a worldwide phenomenon. If the factors that attract or repel students towards a specialty can be identified, it may be possible to encourage them towards it. Choice of specialty as a career depends on the complex interplay of experiences before, during or after exposure to the specialty. Objectives: The aim was to understand perceptions of 1 st year medical students regarding career choices and the specialty of psychiatry through a cross-sectional ...

  15. 1st Meeting of China-ROK Eligibility Assessment Subcommittee Held in Beijing

    2004-01-01

    @@ The 1st Meeting of China-ROK Eligibility Assessment Subcommittee was held in Beijing on May 27. Sun Dawei, Chief Chinese representative and Certification and Accreditation Administration of China (CNCA)Deputy Director of presided over the meeting and Hong Zong, Chief ROK representative and Director of Security Service Standard Department of Technology Standard Institute of the Ministry of Industrial Resources of the Republic of Korea led a delegation to Beijing for the meeting.

  16. 1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection

    Bruce W. Banfield

    2014-09-01

    Full Text Available In recent years, important linkages have been made between RNA granules and human disease processes. On June 8-10 of this year, we hosted a new symposium, dubbed the 1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection. This symposium brought together experts from diverse research disciplines ranging from cancer and neuroscience to infectious disease. This report summarizes speaker presentations and highlights current challenges in the field.

  17. After Meeting: The 1st Maritime Pilotage/Towage Services and Technologies Congress

    Adnan PARLAK

    2016-01-01

    The 1st Maritime Pilotage/Towage Services and Technologies Congress has been organized by UCTEA Chambers of Marine Engineers, UCTEA the Chamber of Turkish Naval Architects & Marine Engineers and Turkish Maritime Pilots’ Association at 23 October 2015, Hilton Hotel, İzmir. In the opening ceremony, two distinguished keynote speakers have presented their presentations. Captain Stein Inge DAHN who is the president of European Maritime Pilots’ Association(EMPA) has given a fulfilling speech ...

  18. Readout-segmented EPI for rapid high resolution diffusion imaging at 3T

    Readout mosaic segmentation has been suggested as an alternative approach to EPI for high resolution diffusion-weighted imaging (DWI). In the readout-segmented EPI (RS-EPI) scheme, segments of k-space are acquired along the readout direction. This reduces geometric distortions due to the decrease in readout time. In this work, further distortion reduction is achieved by combining RS-EPI with parallel imaging (PI). The performance of the PI-accelerated RS-EPI scheme is assessed in volunteers and patients at 3T with respect to both standard EPI and PI-accelerated EPI. Peripherally cardiac gated and non-gated RS-EPI images are acquired to assess whether motion due to brain pulsation significantly degrades the image quality. Due to the low off-resonance of PI-driven RS-EPI, we also investigate if the eddy currents induced by the diffusion gradients are low enough to use the Stejskal-Tanner diffusion preparation instead of the twice-refocused eddy-current compensated diffusion preparation to reduce TE. It is shown that non-gated phase corrected DWI performs equally as well as gated acquisitions. PI-driven DW RS-EPI images with substantially less distortion compared with single-shot EPI are shown in patients-allowing the delineation of structures in the lower parts of the brain. A twice-refocused diffusion preparation was found necessary to avoid blurring in the DWI data. This paper shows that the RS-EPI scheme may be an important alternative sampling strategy to EPI to achieve high resolution T2-weighted and diffusion-weighted images

  19. Readout-segmented EPI for rapid high resolution diffusion imaging at 3T

    Holdsworth, Samantha J.; Skare, Stefan; Newbould, Rexford D. [Lucas Center, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305-5488 (United States); Guzmann, Raphael [Department of Neurosurgery, Stanford University, Stanford, CA (United States); Blevins, Nikolas H. [Department of Otolaryngology, Stanford University, Stanford, CA (United States); Bammer, Roland [Lucas Center, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305-5488 (United States)], E-mail: rbammer@stanford.edu

    2008-01-15

    Readout mosaic segmentation has been suggested as an alternative approach to EPI for high resolution diffusion-weighted imaging (DWI). In the readout-segmented EPI (RS-EPI) scheme, segments of k-space are acquired along the readout direction. This reduces geometric distortions due to the decrease in readout time. In this work, further distortion reduction is achieved by combining RS-EPI with parallel imaging (PI). The performance of the PI-accelerated RS-EPI scheme is assessed in volunteers and patients at 3T with respect to both standard EPI and PI-accelerated EPI. Peripherally cardiac gated and non-gated RS-EPI images are acquired to assess whether motion due to brain pulsation significantly degrades the image quality. Due to the low off-resonance of PI-driven RS-EPI, we also investigate if the eddy currents induced by the diffusion gradients are low enough to use the Stejskal-Tanner diffusion preparation instead of the twice-refocused eddy-current compensated diffusion preparation to reduce TE. It is shown that non-gated phase corrected DWI performs equally as well as gated acquisitions. PI-driven DW RS-EPI images with substantially less distortion compared with single-shot EPI are shown in patients-allowing the delineation of structures in the lower parts of the brain. A twice-refocused diffusion preparation was found necessary to avoid blurring in the DWI data. This paper shows that the RS-EPI scheme may be an important alternative sampling strategy to EPI to achieve high resolution T2-weighted and diffusion-weighted images.

  20. Fast Susceptibility-Weighted Imaging (SWI) with 3D Short-Axis Propeller (SAP)-EPI

    Holdsworth, Samantha J.; Yeom, Kristen W.; Moseley, Michael E.; Skare, S.

    2014-01-01

    Purpose Susceptibility-Weighted Imaging (SWI) in neuroimaging can be challenging due to long scan times of 3D Gradient Recalled Echo (GRE), while faster techniques such as 3D interleaved EPI (iEPI) are prone to motion artifacts. Here we outline and implement a 3D Short-Axis Propeller Echo-Planar Imaging (SAP-EPI) trajectory as a faster, motion-correctable approach for SWI. Methods Experiments were conducted on a 3T MRI system. 3D SAP-EPI, 3D iEPI, and 3D GRE SWI scans were acquired on two volunteers. Controlled motion experiments were conducted to test the motion-correction capability of 3D SAP-EPI. 3D SAP-EPI SWI data were acquired on two pediatric patients as a potential alternative to 2D GRE used clinically. Results 3D GRE images had a better target resolution (0.47 × 0.94 × 2mm, scan time = 5min), iEPI and SAP-EPI images (resolution = 0.94 × 0.94 × 2mm) were acquired in a faster scan time (1:52min) with twice the brain coverage. SAP-EPI showed motion-correction capability and some immunity to undersampling from rejected data. Conclusion While 3D SAP-EPI suffers from some geometric distortion, its short scan time and motion-correction capability suggest that SAP-EPI may be a useful alternative to GRE and iEPI for use in SWI, particularly in uncooperative patients. PMID:24956237

  1. Softball Games Bring NCI and Leidos Biomed Employees Together | Poster

    NCI and Leidos Biomed employees took to the fields at Nallin Pond for the third annual slow-pitch softball games on August 26. The series attracted 54 employees who were divided into four teams, Red, Blue, Gray, and White, and they were cheered on by about 40 enthusiastic spectators. In the first set of games, the Gray team defeated the Blue team, 15–8, and the White team pulled out a win against the Red team, 17–15. After a brief rest, the two winning teams and the two losing teams faced each other in a second set of games. On Field 1, the “winners” match-up of the Gray and White teams was a nail biter, with a close score throughout the game. Daylight was a factor, however, and the team captains decided to call the game for safety reasons. With a lead of 15 to 13, the Gray team was declared the overall winner.

  2. Perception of 1 st year medical students towards career choices and specialty of psychiatry

    Suneet Kumar Upadhyaya

    2015-01-01

    Full Text Available Background: Shortage of psychiatrists is a worldwide phenomenon. If the factors that attract or repel students towards a specialty can be identified, it may be possible to encourage them towards it. Choice of specialty as a career depends on the complex interplay of experiences before, during or after exposure to the specialty. Objectives: The aim was to understand perceptions of 1 st year medical students regarding career choices and the specialty of psychiatry through a cross-sectional questionnaire-based study. Materials and Methods: Perceptions of 137 1 st year medical students from the Government Medical College were recorded using a semi-structured questionnaire. Students provided their opinions about future career choices; perspective of these specialties in terms of financial reward, reputation, work-life balance, challenging aspect, ability to help patients effectively and emotional stability; their preferences in life and interaction with psychiatrist and its impact. Statistical Analysis Used: One-way analysis of variance (ANOVA with post-hoc analysis by Tukey-Kramer test. Results: Surgery was a high priority for 69 (50% while psychiatry was a high priority only for 11 (8%. Surgery was highest for financial reward and reputation, but lowest for work-life balance. Psychiatry had higher emotional stability, however, its the reputation was lower than surgery, medicine, obstetrics and gynaecology and paediatrics. Students preferred reputation (41% over social service opportunities (43%, work-life balance (16%, and high-income (11%. Interaction with psychiatrist increased inclination for psychiatry in 69% (9/13 students. Conclusions: Psychiatry is not a preferred specialty among 1 st year medical students due to its poor reputation.

  3. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    Stahel, R; Thatcher, N; Früh, M;

    2011-01-01

    The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference, the...... expert panel prepared clinically relevant questions concerning five areas as follows: early and locally advanced non-small-cell lung cancer (NSCLC), first-line metastatic NSCLC, second-/third-line NSCLC, NSCLC pathology and molecular testing, and small-cell lung cancer (SCLC) to be addressed through...

  4. 1st and 2nd Trimester Headsize in Fetuses with Congenital Heart Disease: A Cohort Study

    Lauridsen, Mette Høj; Petersen, Olav Bjørn; Vestergaard, Else Marie;

    2014-01-01

    Background: Congenital heart disease (CHD) is associated with neuro-developmental disorders. The influence of CHD on the brain may be present in the fetus. We hypothesize that fetal cerebral growth is impaired as early as 2nd trimester. Aim: To investigate if fetal cerebral growth is associated...... and screening for fetal malformations is carried out. Our cohort includes all fetuses in Western Denmark (2.9 million inhabitants) screened in between January 1st 2012 and December 31st 2013, diagnosed with any structural, non-syndromic congenital heart disease either during pregnancy or up to 6...

  5. 1st International Conference on Business Management - “New Challenges in Business Research”

    Calafat Marzal, Maria Consuelo; Martí Selva, María Luisa

    2015-01-01

    We are glad to announce the 1st International Conference on Business Management “New Challenges in Business Research” that will be held in the Faculty of Business Management and Administration of the Universitat Politècnica de València (Valencia, Spain) on 2nd – 3rd of July, 2015. The aim of the conference is to give researchers the opportunity to get together and present unpublished and relevant research studies about different topics on business management and economics. We belie...

  6. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea

    Bruce F. Bowden

    2003-11-01

    Full Text Available Abstract: An investigation of the soft coral Asterospicularia laurae collected on the Great Barrier Reef, Australia, afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin (1 in addition to the known metabolites 13-epi-9-deacetylxenicin (2 and gorgosterol. 13-Epi-9-deacetoxyxenicin readily underwent an autoxidation reaction in solution to afford a single product, the hydroperoxide 3. Structures, stereochemistry, and NMR assignments were established by high resolution NMR spectroscopy and by comparison with published data for known compounds.

  7. Robust GRAPPA-Accelerated Diffusion-Weighted Readout-Segmented (RS)-EPI

    Holdsworth, Samantha J.; Skare, Stefan; Newbould, Rexford D.; Bammer, Roland

    2009-01-01

    Readout segmentation (RS-EPI) has been suggested as a promising variant to echo-planar imaging (EPI) for high-resolution imaging, particularly when combined with parallel imaging. This work details some of the technical aspects of diffusion-weighted (DW)-RS-EPI, outlining a set of reconstruction methods and imaging parameters that can both minimize the scan time and afford high-resolution diffusion imaging with reduced distortions. These methods include an efficient generalized autocalibratin...

  8. A measurement of E/{pi} for a fast lead liquid argon calorimeter

    Makowiecki, D.; Gordon, H.A.; Ma, H.; Murtagh, M.; Radeka, V.; Rahm, D.; Rescia, S. [Brookhaven National Lab., Upton, NY (United States); Abrams, G.S.; Groom, D.E.; Kirsten, F.; Levi, M.; Siegrist, J. [Lawrence Berkeley Lab., CA (United States); Amako, K.; Inaba, O.; Kondo, T. [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan); Baden, A.R.; Fong, D.; Hadley, N.; Kunori, S.; Skuja, A. [Maryland Univ., College Park, MD (United States); Bowen, T.; Forden, G.; Jenkins, E.; Johns, K.; Rutherfoord, J.; Shupe, M. [Arizona Univ., Tucson, AZ (United States); Burnett, T.; Cook, V.; Davisson, R.; Mockett, P.; Rothberg, J.; Williams, R.W. [Washington Univ., Seattle, WA (United States); Cremaldi, L.; Reidy, J.; Summers, D. [Mississippi Univ., University, MS (United States); DiGiacomo, N. [Martin Marietta Aerospace, Denver, CO (United States). Astronautics Group; Draper, P.; Ferbel, T.; Lobkowicz, F. [Rochester Univ., NY (United States); Faust, J.; Hauptman, J.; Pang, M. [Iowa State Univ. of Science and Technology, Ames, IA (United States); Gabriel, T.A. [Oak Ridge National Lab., TN (United States); Hagopian, V.; Womersley, J. [Florida State Univ., Tallahassee, FL (United States); Handler, T. [Tennessee Univ., Knoxville, TN (United States); Hitlin, D. [California Inst. of Tech., Pasadena, CA (United States); Mulholland, G.T. [Fermi National Accelerator Lab., Batavia, IL (United States); Watanabe, Y. [Tokyo Inst. of Tech. (Japan); Weerts, H. [Michigan State Univ., East Lansing, MI (United States)

    1990-12-31

    The NA34 (HELIOS) calorimeter has measured e/{pi} {congruent} 1.1 in a uranium/liquid argon calorimeter with a shaping time of 135 nsec. Lead may be a viable alternative, but e/{pi} must first be measured at fast shaping times in lead. We re preparing to measure e/{pi} at momenta ranging from 0.5 to 20 GeV/c and with shaping times of 50, 100 and 150 nsec.

  9. Remote Laboratory NetLab for Effective Teaching of 1st Year Engineering Students

    Z. Nedic

    2007-08-01

    Full Text Available Practical skills are important attributes of every engineering graduate. The Internet has provided tertiary education with the opportunity to develop innovative learning environments. The teaching and learning of practical skills has gained a new dimension with the emergence of remote laboratories. The rapidly growing number of remote laboratories (RL worldwide is the evidence that the educational community has recognized their potential to develop into a creative, flexible, engaging, and student-cantered learning environment. Even a brief review of the existing RLs shows a large diversity in their structure, design and implementation. However, not many researchers disclose how their RLs are integrated within their curricula. Therefore, an important question still remains to be answered: how to optimize the design of RLs and their integration in a course curriculum for the best learning outcomes? This problem is particularly important when RLs are used in teaching 1st year students who have limited technical knowledge and practical experience in using real equipment. In this paper we would like to share our experiences with NetLab, an RL developed at the University of South Australia (UniSA for teaching 1st year engineering students and make recommendations for improvements in teaching practices based on it.

  10. Dipolar interactions and hydrogen bonding in supramolecular aggregates: understanding cooperative phenomena for 1st hyperpolarizability.

    Datta, Ayan; Pati, Swapan K

    2006-12-01

    Weak intermolecular forces like dipolar interactions and hydrogen-bonding lead to a variety of different packing arrangements of molecules in crystals and self-assemblies. Such differences in the arrangements change the extent of excitonic splitting and excitation spectra in the multichromophore aggregates. In this tutorial review, the role of such interactions in fine tuning the linear and 1st non-linear optical (NLO) responses in molecular aggregates are discussed. The non-additivity of these optical properties arise specifically due to such cooperative interactions. Calculations performed on dimers, trimers and higher aggregates for model systems provide insights into the interaction mechanisms and strategies to enhance the 1st hyperpolarizabilities of pi-conjugated molecular assemblies. Flexible dipole orientations in the alkane bridged chromophores show odd-even variations in their second-harmonic responses that are explained through their dipolar interactions in different conformations. Parameters for the optical applications of molecules arranged in constrained geometry, like in Calix[n]arene, have been elucidated. We also highlight the recent developments in this field of research together with their future prospects. PMID:17225890

  11. NCI Takes Back the Defelice Cup at Ninth Annual Golf Tournament | Poster

    By Ashley DeVine, Staff Writer After being down by a point in the morning, NCI reclaimed the Defelice Cup trophy from Leidos Biomedical Research, with a final score of 12 ½ to 11 ½, at the ninth annual Ronald H. Defelice Golf Tournament, held Oct. 13. “The tightest matches in the nine-year history of this cup competition resulted in a narrow victory for NCI and allowed NCI to take a 5–4 victory total,” said Denny Dougherty, one of the team captains for Leidos Biomed and a retired senior subcontracts advisor at what was formerly SAIC-Frederick.

  12. Effect on rabbit corneal haze after EpiLASIK and flap-free Epi-LASIK%上皮瓣弃留对兔Epi-LASIK术后haze影响的研究

    陈静; 韩苏宁; 毕媛; 杨传红; 朱海萍; 邓红燕

    2011-01-01

    目的 观察角膜上皮下雾状混浊(haze)形成过程中转化生长因子β2(transforming growth factor β2,TGF-β2)在兔机械法准分子激光上皮瓣下角膜磨镶术(epipolis laser in situ keratomileusis,Epi-LASIK)和去瓣Epi-LASIK术后的表达差异,并探讨上皮瓣弃留对Epi-LASIK术后haze形成的影响.方法24只新西兰白兔,双眼分别建立Epi-LASIK和去瓣Epi-LASIK模型.裂隙灯显微镜下观察术后1个月、2个月、3个月角膜haze的情况,免疫组织化学SABC法检测角膜组织TGF-β2的表达.结果Epi-LASIK组和去瓣Epi-LASIK组haze分级情况在术后1个月、2个月、3个月差异均无统计学意义(x2 =0.08、0.58、0.25,均为P>0.05).Epi-LASIK组术后1个月、2个月、3个月TGF-β2的表达分别为8 546.42 ±2013.25、7831.62±1560.27、6253.21±1962.35,去瓣Epi-LASIK组术后1个月、2个月、3个月1GF-β2的表达分别为8037.21±1634.29、6994.56±2013.58、6042.58±1862.24,2组术后各时间点角膜组织TGF-β2的表达差异均无统计学意义(t=0.96、1.31、0.38,均为P>0.05);组内比较,随时间延长,TGF-β2的表达呈逐渐降低的趋势.结论 上皮瓣弃留对Epi-LASIK术后各时间点角膜组织TGF-β2的表达及haze发生程度均无明显影响.%Objective To observe the expression of transforming growth factor β2(TGF-β2) after epipolis laser in situ keratomileusis (Epi-LASIK) and flap-free Epi-LASIK on rabbit during the process of haze forming,and discuss the difference between Epi-LASIK and flap-free Epi-LASIK effect on haze forming after the operation. Methods Epi-LASIK was performed in one eye of 24 New Zealand rabbits and flap-free Epi-LASIK in the other eye. The grades of haze were observed at 1 month,2 months and 3 months after operation under slit lamp,the expression of TGF-β2 in cornea was examined by immunohistochemistry. Resvlts There was no statistical difference in haze grade between Epi-LASIK and flap-free Epi-LASIK at postoperative 1 month,2

  13. A comparative study of stromal reaction in Epi-on & Epi-off techniques post- C3R in Keratoconus patients with OCT.

    Dr. Suruchi B. Agarwal

    2014-12-01

    Full Text Available TITLE: A patient study of Stromal Reaction after C3R with OCT and comparing Epi-On & Epi-Off techniques in Keratoconus patients. PURPOSE: To report a study of 20 patients of keratoconus showing the effect on the corneal structure and stromal reaction in post Corneal Collagen Cross Linking (C3R, through the Anterior Segment imaging technique- OCT METHODS: A Study was done from 15.7.2014 to 30.9.2014 of 20 patients having keratoconus, progressive type, where Collagen Cross linking was decided as the method of management (10 each of Epi-on and Epi-off technique. In the Epi-off technique, the epithelium was removed prior to corneal soakage of a dextran-based 0.1% photo sensitizer riboflavin solution for 30 minutes, followed by exposure of ultraviolet-A (typically 365-370 μm light for 30 min with an intensity of 3 mW/cm 2 and 5.4 J/cm 2 of energy. In the Epi-on technique, a special dextran-trometamol EDTA based 0.1% riboflavin solution is used without scrapping the cornea, rest of the method is same. One week after the C3R procedure, the anterior segment OCT was done. RESULTS: In the first few weeks after cross-linking, a faint hyper reflectivity is noted in the anterior stroma, a distinct demarcation between the cross-linked and non-cross-linked areas of the cornea, the depth of demarcation line and the change in the corneal thickness was noted. CONCLUSION: In both the Epi-on and Epi-off technique, the change in the stromal thickness and demarcation line is same. Hence we conclude that both the techniques are equally effective.

  14. NCI Requests Targets for Monoclonal Antibody Production and Characterization - Office of Cancer Clinical Proteomics Research

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution.

  15. NCI Launches Proteomics Assay Portal - Office of Cancer Clinical Proteomics Research

    In a paper recently published by the journal Nature Methods, Investigators from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (NCI-CPTAC) announced the launch of a proteomics Assay Portal for multiple reaction monitoring-mass

  16. Gestió integral de RRHH basada en competències

    Arpi Soler, María José

    2005-01-01

    El projecte ha consistit en el disseny d'un sistema de gestió de recursos humans basat en competències. En concret, el projecte s'ha realitzat a l'empresa on treballo en l'actualitat, i s'ha basat en la descripció de les funcions i competències necessàries per a cadascuna de les professions de l'organització, la definició d'aquestes competències i les conductes associades al seu acompliment i l'establiment d'un sistema d'avaluació d'aquestes competències. El proyecto ha consistido en el di...

  17. NCI and the Chinese Academy of Medical Sciences Sign Statement of Intent

    Today the National Cancer Institute (NCI) and the Cancer Institute/Hospital of the Chinese Academy of Medical Sciences (CICAMS) signed a statement of intent to share an interest in fostering collaborative biomedical research in oncology and a common goal

  18. National Medal of Technology Awarded to NCI Drs. Lowy and Schiller

    President Obama announced that two NCI scientists would be recipients of the National Medal of Technology and Innovation -- the nation's highest honor for technological achievement. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO)

  19. 75 FR 4827 - Submission for OMB Review; Comment Request Clinical Trials Reporting Program (CTRP) Database (NCI)

    2010-01-29

    ... clinical trials conducted by large pharmaceutical companies. The NCI sent an e-mail response on January 8... or other forms of information technology. Direct Comments to OMB: Written comments and/or...

  20. Teletandem e episódios relacionados a cultura

    João Antonio TELLES

    2015-12-01

    Full Text Available Teletandem é um contexto telecolaborativo de aprendizagem que envolve dois falantes nativos (ou competentes de diferentes línguas. Utilizando o Skype, cada participante faz papel de aluno por meia hora, falando e praticando a língua do seu parceiro. Este artigo enfoca a interação em teletandem entre dois estudantes universitários - uma brasileira e um estadunidense. Na primeira parte, sustentamos nossa pressuposição de que os participantes do teletandem compartilham informações acerca das respectivas culturas. Na segunda, apresentamos cinco dimensões do conceito de cultura, definimos aprendizagem cultural e propomos uma unidade de análise para interpretação dos dados - o episódio relacionado a cultura. Por fim, sugerimos diretrizes para futuras pesquisas relacionadas à aprendizagem de línguas e culturas em contextos colaborativos on-line.

  1. Uniqueness in multispectral constant-wave epi-illumination imaging.

    Garcia-Allende, P B; Radrich, K; Symvoulidis, P; Glatz, J; Koch, M; Jentoft, K M; Ripoll, J; Ntziachristos, V

    2016-07-01

    Multispectral tissue imaging based on optical cameras and continuous-wave tissue illumination is commonly used in medicine and biology. Surprisingly, there is a characteristic absence of a critical look at the quantities that can be uniquely characterized from optically diffuse matter by multispectral imaging. Here, we investigate the fundamental question of uniqueness in epi-illumination measurements from turbid media obtained at multiple wavelengths. By utilizing an analytical model, tissue-mimicking phantoms, and an in vivo imaging experiment we show that independent of the bands employed, spectral measurements cannot uniquely retrieve absorption and scattering coefficients. We also establish that it is, nevertheless, possible to uniquely quantify oxygen saturation and the Mie scattering power-a previously undocumented uniqueness condition. PMID:27367111

  2. Extremal properties of (epi)Sturmian sequences and distribution modulo 1

    Allouche, Jean-Paul; Glen, Amy

    2009-01-01

    Starting from a study of Y. Bugeaud and A. Dubickas (2005) on a question in distribution of real numbers modulo 1 via combinatorics on words, we survey some combinatorial properties of (epi)Sturmian sequences and distribution modulo 1 in connection to their work. In particular we focus on extremal properties of (epi)Sturmian sequences, some of which have been rediscovered several times.

  3. EDITORIAL: The 1st International Conference on Nanomanufacturing (NanoMan2008) The 1st International Conference on Nanomanufacturing (NanoMan2008)

    Luo, Jack Jiqui; Fang, Fengzhou

    2009-05-01

    Nanomanufacturing is an emerging technology in the field of synthesis of nanomaterials, manufacture of nanodevices, nanosystems and the relevant characterization technologies, and will greatly impact our society and environment: speeding up scientific discovery, technological development, improving healthcare and living standards and slowing down the exhaustion of energy resources, to name but few. The 1st International Conference on Nanomanufacturing (NanoMan2008) was held on the 13-16 July 2008 in Singapore in conjunction with ThinFilm2008 (The 4th International Conference on Technological Advances of Thin Films & Surface Coatings). Approximately 140 delegates from all over the world have participated in the conference and presented their latest discoveries and technological developments. The main focuses of the conference were modern nanomanufacturing by laser machining, focused ion beam fabrication, nano/micro-molding/imprinting, nanomaterial synthesis and characterization, nanometrology and nano/microsystems fabrication and characterization. There was also great interest in applications of nanomanufacturing technologies in traditional areas such as free form machining, polishing and grinding with nano-scale precision and the smoothness of surfaces of objects, and applications in space exploration, military and medicine. This special issue is devoted to NanoMan2008 with a collection of 9 invited talks presented at the conference, covering all the topics of nanomanufacturing technology and development. These papers have been upgraded by the authors with new results and discoveries since the preparation of the conference manuscripts, hence presenting the latest developments. We would like to take this opportunity to thank all the delegates who attended the conference and made the conference successful, and to the authors who contributed papers to this special issue. Thanks also go to the conference committee for their efforts and devotion to the conference. We

  4. THE NEW FACILITIES MANAGEMENT CONTRACT AT CERN FROM 1st JULY 2002

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent contro...

  5. The new Facilities Management contract at CERN from 1st July 2002

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: - Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, - Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent cont...

  6. 1st European-Middle Asian Conference on Computer Modelling 2015

    Kolosov, Dmitrii; Snášel, Václav; Karakeyev, Taalaybek; Abraham, Ajith

    2016-01-01

    This volume of Advances in Intelligent Systems and Computing contains papers presented at the 1st European-Middle Asian Conference on Computer Modelling, EMACOM 2015. This international conference was conceived as a brand new scientific and social event of mutual collaboration between the VSB - Technical University of Ostrava (Ostrava, Czech Republic) and the Kyrgyz National University named after J. Balasagyn (Bishkek, Kyrgyz Republic). The aim of EMACOM 2015 was to present the latest development in the field of computer-aided modelling as an essential aspect of research and development of innovative systems and their applications. The conference showed that together with simulations, various modeling techniques, enabled and encouraged by the rapid development of high-performance computing platforms, are crucial for cost-efficient design, verification, and prototyping of solutions in many diverse industrial fields spanning the whole range from manufacturing, mining, machinery, and automotive industries to in...

  7. Environmental engineering education - summary report of the 1st European Seminar

    Alha, K; Holliger, C.; Larsen, Bo Skjold;

    2000-01-01

    This paper summarizes the discussions of the 1st European Seminar on Environmental Engineering Education (E3), which was held at EAWAG, Zurich, Switzerland in August 1999. Although the emerging discipline of environmental engineering, which was once viewed as being a sub-set of civil or chemical...... engineering, has established a status in its own right, a definition of environmental engineering is still not agreed among European engineering educators. This report discusses the variation between European countries and the way in which higher education institutions in these countries address the...... educational needs of environmental engineers. A review of the acceptance of this new discipline by employers and the status of environmental engineering as a profession throughout Europe is presented. The question of how to achieve greater compatibility and comparability of the systems of environmental...

  8. Proceedings of the 1st International Workshop on High-Speed and Intercity Railways

    Ye, Xiao-Wei

    2012-01-01

    This book contains the papers included in the proceedings of the 1st International Workshop on High-speed and Intercity Railways (IWHIR 2011) held in Shenzhen and Hong Kong, China from July 19 to July 22, 2011, which is organized by The Hong Kong Polytechnic University, in collaboration with Southwest Jiaotong University, Beijing Jiaotong University, Dalian Jiaotong University, China Engineering Consultants, Inc., Zhejiang University, and Tsinghua University. Continuing the great initiatives and momentums of the rapid development in high-speed and intercity railways worldwide in recent years, IWHIR 2011 aims at providing a platform for academic scholars and practicing engineers to share knowledge and experience, to promote collaboration, and to strengthen R&D activities related to railway engineering. Engineers, scientists, professors, and students from universities, research institutes, and related industrial companies have been cordially invited to participate in the workshop. These papers have covered ...

  9. Design of a new research reactor : 1st year conceptual design

    A new research reactor model satisfying the strengthened regulatory environments and the changed circumstances around nuclear society should be prepared for the domestic and international demand of research reactor. This can also lead to the improvement of technologies and fostering manpower obtained during the construction and the operation of HANARO. In this aspect, this study has been launched and the 1st year conceptual design has been carried out in 2003. The major tasks performed at the first year of conceptual design stage are as follows; Establishments of general design requirements of research reactors and experimental facilities, Establishment of fuel and reactor core concepts, Preliminary analysis of reactor physics and thermal-hydraulics for conceptual core, Conceptual design of reactor structure and major systems, International cooperation to establish foundations for exporting

  10. Virtual Visit to the ATLAS Control Room by 1st and 3rd Lyceums in Chios

    2013-01-01

    High school students from the 1st and 3rd Lyceums of Chios, Greece, will be visiting the control room of ATLAS to discuss the latest results on the Higgs search, LHC’s first long shutdown and what the future holds for the ATLAS experiment. This visit takes place in the context of a Masterclass where students will learn how to analyse real events from the LHC with the use of the HYPATIA online applet based on educational scenarios from the Discover the COSMOS portal. This full-day activity is organized by the University of Athens, the University of the Aegean, Ellinogermaniki Agogi and the Chios Physical Society in the framework of the Open Discovery Space EU project.

  11. 1st International Conference on Computational Advancement in Communication Circuits and Systems

    Dalapati, Goutam; Banerjee, P; Mallick, Amiya; Mukherjee, Moumita

    2015-01-01

    This book comprises the proceedings of 1st International Conference on Computational Advancement in Communication Circuits and Systems (ICCACCS 2014) organized by Narula Institute of Technology under the patronage of JIS group, affiliated to West Bengal University of Technology. The conference was supported by Technical Education Quality Improvement Program (TEQIP), New Delhi, India and had technical collaboration with IEEE Kolkata Section, along with publication partner by Springer. The book contains 62 refereed papers that aim to highlight new theoretical and experimental findings in the field of Electronics and communication engineering including interdisciplinary fields like Advanced Computing, Pattern Recognition and Analysis, Signal and Image Processing. The proceedings cover the principles, techniques and applications in microwave & devices, communication & networking, signal & image processing, and computations & mathematics & control. The proceedings reflect the conference’s emp...

  12. Challenges of changing a PBL-related curriculum for 1st year students

    Bruun-Pedersen, Jon Ram; Kofoed, Lise B.

    2011-01-01

    This paper discusses a transition related to a reformed study plan in the specific case of the Aalborg University education of Medialogy; a Bachelor and Master program with an average of 80 students starting 1st semester. Among other things, the change meant a new structure for preparation......, teaching and evaluation for the course: Cooperation, Learning and Project Management (CLP). This paper will discuss the implications, based on the students’understanding of the subject matter, the degree of practical use of the course curriculum in their project work, and compare it to the former study...... of clear learning goals has shown to be constructive, especially if included more clearly as an explicit part of the lectures than it has been the case. It suggests to use them as a pedagogical method, leading to both subject matter overview and guidance towards the expected level of understanding...

  13. Proceedings of the 1st Nordic Optimization Symposium - 10th Nordic MPS meeting, Copenhagen 2006

    Clausen, Jens; Jørgensen, Rene Munk; Kohl, Niklas;

    2006-01-01

    On behalf of the Technical University of Denmark, the Danish Operations Research Society and the Nordic Section of the Mathematical Programming Society we welcome you to Copenhagen and the 1st Nordic Optimization Symposium - the 10th meeting of the Nordic MPS. The meetings of the Nordic MPS have...... evolved to be more that just a meeting on Mathematical Programming. They are a forum for discussing a wide range of related areas and practical cases. In the organizing committee we wanted the name of the meeting to reflect this. We have therefore in agreement with the board of the Nordic MPS suggested to...... add a new title, that reflects the much broader field that is our playground at these meetings. Still the odd trustworthy title “Meeting of the Nordic MPS” has been maintained to demonstrate the origin of the symposium. It is our hope that future Nordic MPS meetings will carry on using this “double...

  14. 1st International Symposium and 10th Balkan Conference on Operational Research

    Sifaleras, Angelo; Georgiadis, Christos; Papathanasiou, Jason; Stiakakis, Emmanuil

    2013-01-01

    Over the past two decades, the Balkan Conference on Operational Research (BALCOR) has facilitated the exchange of scientific and technical information on the subject of Operations Research and related fields such as Mathematical Programming, Game Theory, Multiple Criteria Decision Analysis, Information Systems, Data Mining, and more, in order to promote international scientific cooperation.  The contributed papers contained in this volume consist of 25 selected research papers based on results presented at the 10th Balkan Conference & 1st International Symposium on Operational Research in Thessalonike, Greece. Subjects include, but do not restrict to, the development of theory and mathematical models for Operations Research, theory and applications of Combinatorial Optimization, Supply Chain Optimization, and Military Operations Research.  These carefully selected papers present important recent developments and modern applications, and will serve as excellent reference for students, researchers, and pr...

  15. Environmental engineering education - summary report of the 1st European Seminar

    Alha, K; Holliger, C.; Larsen, Bo Skjold; Purcell, P.; Rauch, W.

    2000-01-01

    engineering, has established a status in its own right, a definition of environmental engineering is still not agreed among European engineering educators. This report discusses the variation between European countries and the way in which higher education institutions in these countries address the......This paper summarizes the discussions of the 1st European Seminar on Environmental Engineering Education (E3), which was held at EAWAG, Zurich, Switzerland in August 1999. Although the emerging discipline of environmental engineering, which was once viewed as being a sub-set of civil or chemical...... educational needs of environmental engineers. A review of the acceptance of this new discipline by employers and the status of environmental engineering as a profession throughout Europe is presented. The question of how to achieve greater compatibility and comparability of the systems of environmental...

  16. The 1st Fermi LAT SNR Catalog: the Impact of Interstellar Emission Modeling

    Brandt, T J; de Palma, F; Johannesson, G; Tibaldo, L

    2013-01-01

    Galactic interstellar emission contributes substantially to Fermi LAT observations in the Galactic plane, the location of the majority of supernova remnants (SNRs). To explore some systematic effects on SNRs' properties caused by interstellar emission modeling, we have developed a method comparing the official LAT interstellar emission model results to eight alternative models. We created the eight alternative Galactic interstellar models by varying a few input parameters to GALPROP, namely the height of the cosmic ray propagation halo, cosmic ray source distribution in the Galaxy, and atomic hydrogen spin temperature. We have analyzed eight representative SNRs chosen to encompass a range of Galactic locations, extensions, and spectral properties using the eight different interstellar emission models. We will present the results and method in detail and discuss the implications for studies such as the 1st Fermi LAT SNR Catalog.

  17. Idaho National Laboratory Quarterly Occurrence Analysis - 1st Quarter FY 2016

    Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 74 reportable events (16 from the 1st Qtr FY-16 and 58 from the prior three reporting quarters), as well as 35 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (15 from this quarter and 20 from the prior three quarters).

  18. Mock-up test of the high level liquid waste solidification rpcess (1st campaign)

    In the Power Reator and Nuclear Fuel Development Corporation (PNC), plans are in progress for the completion of a pilot plant for the glass solidification of liquid-wastes in fiscal 1987, intended for the high-level liquid wastes from the fuel reprocessing plant of PNC. The mock-up test facility for this pilot plant is for grasping the operating characteristics of the process and the development of the remote operation and maintenance techniques. The test facility is composed of the stages of liquid waste pretreatment, glass material feed, glass melting, off-gas treatment, canister handling, and secondary-waste treatment. The following matters are described: mock-up test building, process constitution, machinery arrangement, operation control, test plans, and operation test results (1st campaign: pretreatment/off-gas treatment, and glass melting). (Mori, K.)

  19. 2007 EORTC-NCI-ASCO Annual Meeting: Molecular Markers in Cancer

    Lukan, C

    2008-01-01

    The recent EORTC-NCI-ASCO Annual Meeting on ‘Molecular Markers in Cancer’ was held on 15–17 November 2007 in Brussels, Belgium. It was the largest meeting to date and marked the first year in which the American Association of Clinical Oncology (ASCO) joined in the efforts of the European Organisation for Research and Treatment of Cancer (EORTC) and the National Cancer Institute (NCI) in organizing this annual event. More than 300 clinicians, pathologists, laboratory scientists and representat...

  20. Revue de l'EPI n° 97 de mars 2000

    Viaud, Jean-Bernard

    2000-01-01

    Sommaire. Revue de l'EPI (Enseignement Public et Informatique), (97), mars 2000. 2-3. b97p002EPI, Viaud, J.-B. (2000). Éditorial. Revue de l'EPI (Enseignement Public et Informatique), (97). 5-7. b97p005Bancel, D., M.E.N. (2000). Réforme des lycées : organisation des travaux personnels encadrés en classe de première. Revue de l'EPI (Enseignement Public et Informatique), (97). 19-20. b97p019Allégre, C., M.E.N. (2000). Extraits des voeux de Claude Allègre à la presse. Revue de l'EPI (Enseignemen...

  1. Implementation and Application of PSF-Based EPI Distortion Correction to High Field Animal Imaging

    Dominik Paul

    2009-01-01

    Full Text Available The purpose of this work is to demonstrate the functionality and performance of a PSF-based geometric distortion correction for high-field functional animal EPI. The EPI method was extended to measure the PSF and a postprocessing chain was implemented in Matlab for offline distortion correction. The correction procedure was applied to phantom and in vivo imaging of mice and rats at 9.4T using different SE-EPI and DWI-EPI protocols. Results show the significant improvement in image quality for single- and multishot EPI. Using a reduced FOV in the PSF encoding direction clearly reduced the acquisition time for PSF data by an acceleration factor of 2 or 4, without affecting the correction quality.

  2. SBK与Epi-LASIK治疗高度近视疗效比较%Comparison of the effect of SBK and Epi-LASIK on correcting high myopia

    陈静; 韩苏宁; 朱海萍; 邓红燕

    2012-01-01

    Objective To evaluate the efficacy of sub-Bowman keratomileusis (SBK) and epipolis laser in situ keratomileusis (Epi-LASIK) for correcting high myopia. Methods Ninety-one patients (182 eyes) underwent SBK or Epi-LASIK surgery for correcting high myopia,including 53 patients (106 eyes) for SBK and 38 patients (76 eyes) for Epi-LASIK.Visual acuity,remained diopter and corneal haze were examined after operation.The results were analyzed statistically. Results Patients had different degree of uncomfortable feeling early time after Epi-LASIK.Both groups showed no keratectasia by corneal topography examination 6 months after operation.One week postoperatively,the proportion of visual acuity ≥0.8 for SBK (77.4%) was more than that for Epi-LASIK (46.1%) (P < 0.05).No significant differences were found in that of SBK (92.5%,95.3%,94.3%)and that of Epi-LASIK (85.5%,94.7%,90.8%) one-month,three-months and six-months postoperatively (P > 0.05).The recovery of visual acuity after SBK was quicker than Epi-LASIK.There was no statistic meaning of remained diopter between SBK [(-0.24±0.42)D,(-0.38±0.51)D,(-0.40±0.46)D]and Epi-LASIK [(-0.32±0.40)D,(-0.44±0.60)D,(-0.52±0.55)D] 1 month,3 months and 6 months postoperatively (P > 0.05).Both groups showed no refractive regression after operation.Haze was not found in SBK group.0.5 degree of haze was found in 2 eyes after Epi-LASIK 3 months postoperatively,and was disappeared 6 months postoperatively. Conclusions SBK and Epi-LASIK are both safe and effective for correcting high myopia.SBK is superior to Epi-LASIK in respect of visual acuity recovery at early time.%目的 探讨准分子激光前弹力层下角膜磨镶术(sub-Bowman keratomileusis,SBK)和机械法准分子激光上皮瓣下角膜磨镶术(epipolis laser in situ keratomileusis,Epi-LASIK)矫治高度近视的疗效.方法 对91例(182只眼)高度近视患者进行SBK或Epi-LASIK手术.其中53例(106只眼)行SBK术,38例(76只眼)行Epi

  3. Comparison of the results of T-Test from different versions of Epi Info

    Junke Tang; Jinliang Zhu

    2005-01-01

    Objective: To take advantage of Epi Info to manage and analyze disease data. Methods: After selecting the living examples for independent sample T-Test, Epi Info 5.00, 5.01a(Chinese), 6.00, 6.04 b, 6.04 d, 2000, 2002(Chinese)were used to do the independent sample T-Test on the two living examples. Then, Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were used to verify the results. Results: The statistical results from the Epi Info 5.00, 5.01a(Chinese) and 6.00 were the same while that from Epi Info 6.04 b, 6.04 d, 2000,2002 (Chinese), Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were identical In independent sample T-Test,. But the former result is different with the latter. Conclusion: There was an error in the result of T-Test from Epi Info 6.00 and former versions. Thus, it's important to be alert to select the versions of Epi Info to manage and analyze disease data. On the other hand, it's also quite pivotal to distinguish the adopted Epi Info versions when referring to the articles ane use the statistical results.

  4. PREFACE: 1st European Conference on Gas Micro Flows (GasMems 2012)

    Frijns, Arjan; Valougeorgis, Dimitris; Colin, Stéphane; Baldas, Lucien

    2012-05-01

    The aim of the 1st European Conference on Gas Micro Flows is to advance research in Europe and worldwide in the field of gas micro flows as well as to improve global fundamental knowledge and to enable technological applications. Gas flows in microsystems are of great importance and touch almost every industrial field (e.g. fluidic microactuators for active control of aerodynamic flows, vacuum generators for extracting biological samples, mass flow and temperature micro-sensors, pressure gauges, micro heat-exchangers for the cooling of electronic components or for chemical applications, and micro gas analyzers or separators). The main characteristic of gas microflows is their rarefaction, which for device design often requires modelling and simulation both by continuous and molecular approaches. In such flows various non-equilibrium transport phenomena appear, while the role played by the interaction between the gas and the solid device surfaces becomes essential. The proposed models of boundary conditions often need an empirical adjustment strongly dependent on the micro manufacturing technique. The 1st European Conference on Gas Micro Flows is organized under the umbrella of the recently established GASMEMS network (www.gasmems.eu/) consisting of 13 participants and six associate members. The main objectives of the network are to structure research and train researchers in the fields of micro gas dynamics, measurement techniques for gaseous flows in micro experimental setups, microstructure design and micro manufacturing with applications in lab and industry. The conference takes place on June 6-8 2012, at the Skiathos Palace Hotel, on the beautiful island of Skiathos, Greece. The conference has received funding from the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement ITN GASMEMS no. 215504. It owes its success to many people. We would like to acknowledge the support of all members of the Scientific Committee and of all

  5. The use of electron beams in radiotherapy: 1st e-learning course in Latin America

    Full text: Radiotherapy in Brazil has now about 80 linear accelerators with electron beams. Due to the continental dimensions of the country, training of medical physicists is still a problem, because many of these physicists are far from the main training centers (Rio de Janeiro and Sao Paulo) and cannot afford to spend any time there. In other cases, they cannot leave the work since there are not enough physicists at their hospital. Then, the Quality Assurance Programme of the National Cancer Institute, whose mission is to improve the quality of the radiotherapeutic treatments in Brazil, decided to create its 1st e-learning course to help the medical physicists perform a correct electron beam dosimetry, according to the IAEA TRS-398 and quality control tests based on the IAEA-TECDOC-1151. The course had the collaboration of the Public Health National School (Fiocruz) and covers the following subjects: 1) therapeutic linear accelerator electron beams: history, production and clinical application, 2) dosimetric equipment and calibration methods, 3) quality control. It is a 60 hour course, totally at a distance and pedagogically based on the basic principle of constructivism. It is the 1st course on the subject and under this model in Brazil and all Latin America. The students receive a high quality book and CD-ROM (with all the material of the course, including four films with the dosimetric measurements in practice). They also count on full time tutors specially trained in a virtual environment, through which they can communicate with the tutors and among themselves, access a virtual library and participate in special forums. By the end of each subject of the course, the students have to answer questions or perform measurements, which are evaluated by the tutors (receiving specific degrees). The course has been announced during only two weeks. We received 161 registrations. Five times more than anticipated. We selected 81 candidates that have been divided in four

  6. PREFACE: 1st International Conference on Rheology and Modeling of Materials

    Gömze, László A.

    2015-04-01

    Understanding the rheological properties of materials and their rheological behaviors during their manufacturing processes and in their applications in many cases can help to increase the efficiency and competitiveness not only of the finished goods and products but the organizations and societies also. The more scientific supported and prepared organizations develop more competitive products with better thermal, mechanical, physical, chemical and biological properties and the leading companies apply more competitive knowledge, materials, equipment and technology processes. The idea to organize in Hungary the 1st International Conference on Rheology and Modeling of Materials we have received from prospective scientists, physicists, chemists, mathematicians and engineers from Asia, Europe, North and South America including India, Korea, Russia, Turkey, Estonia, France, Italy, United Kingdom, Chile, Mexico and USA. The goals of ic-rmm1 the 1st International Conference on Rheology and Modeling of Materials are the following: • Promote new methods and results of scientific research in the fields of modeling and measurements of rheological properties and behavior of materials under processing and applications. • Change information between the theoretical and applied sciences as well as technical and technological implantations. • Promote the communication between the scientists of different disciplines, nations, countries and continents. The international conference ic-rmm1 provides a platform among the leading international scientists, researchers, PhD students and engineers for discussing recent achievements in measurement, modeling and application of rheology in materials technology and materials science of liquids, melts, solids, crystals and amorphous structures. Among the major fields of interest are the influences of material structures, mechanical stresses temperature and deformation speeds on rheological and physical properties, phase transformation of

  7. Advanced Epi Tools for Gallium Nitride Light Emitting Diode Devices

    Patibandla, Nag; Agrawal, Vivek

    2012-12-01

    Over the course of this program, Applied Materials, Inc., with generous support from the United States Department of Energy, developed a world-class three chamber III-Nitride epi cluster tool for low-cost, high volume GaN growth for the solid state lighting industry. One of the major achievements of the program was to design, build, and demonstrate the world’s largest wafer capacity HVPE chamber suitable for repeatable high volume III-Nitride template and device manufacturing. Applied Materials’ experience in developing deposition chambers for the silicon chip industry over many decades resulted in many orders of magnitude reductions in the price of transistors. That experience and understanding was used in developing this GaN epi deposition tool. The multi-chamber approach, which continues to be unique in the ability of the each chamber to deposit a section of the full device structure, unlike other cluster tools, allows for extreme flexibility in the manufacturing process. This robust architecture is suitable for not just the LED industry, but GaN power devices as well, both horizontal and vertical designs. The new HVPE technology developed allows GaN to be grown at a rate unheard of with MOCVD, up to 20x the typical MOCVD rates of 3{micro}m per hour, with bulk crystal quality better than the highest-quality commercial GaN films grown by MOCVD at a much cheaper overall cost. This is a unique development as the HVPE process has been known for decades, but never successfully commercially developed for high volume manufacturing. This research shows the potential of the first commercial-grade HVPE chamber, an elusive goal for III-V researchers and those wanting to capitalize on the promise of HVPE. Additionally, in the course of this program, Applied Materials built two MOCVD chambers, in addition to the HVPE chamber, and a robot that moves wafers between them. The MOCVD chambers demonstrated industry-leading wavelength yield for GaN based LED wafers and industry

  8. Some Yields in the Thermal- and Epi-Cadmium-Neutron Fission of Pu239

    The yields of several nuclides in the thermal- and epi-cadmium-neutron fission of Pu239 have been measured and are reported. In epi-cadmium-neutron fission a decrease, relative to thermal fission, in the yields of Ag111 and Ag113, i.e. an increased peak-to-valley ratio, was found. The yield of As77 and As78, which represent, highly unsymmetrical fission, were found to be greater in epi-cadmium-neutron fission than in thermal fission. This result is' shown to be inconsistent with the simple two mode of fission hypothesis. (author)

  9. Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis.

    Gou, Jun-Bo; Li, Zhen-Qiu; Li, Chang-Fu; Chen, Fang-Fang; Lv, Shi-You; Zhang, Yan-Sheng

    2016-09-01

    Junenol based-eudesmanolides have been detected in many compositae plant species and were reported to exhibit various pharmacological activities. So far, the gene encoding junenol synthase has never been isolated. Here we report the molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis (designated IhsTPS1). IhsTPS1 converts the substrate farnesyl diphosphate into multiple sesquiterpenes with the product 10-epi-junenol being predominant. The transcript levels of IhsTPS1 correlate well with the accumulation pattern of 10-epi-junenol in I. hupehensis organs, supporting its biochemical roles in vivo. PMID:27231873

  10. A Helmet-type MEG System with 1st order SQUID Gradiometer Located in Vacuum

    We have fabricated a helmet type magnetoencephalogrphy(MEG) with a 1st order gradiometer in vacuum to improve the signal-to-noise ratio(SNR) and the boil-off rate of liquid helium(LHe). The axial type first-order gradiometer was fabricated with a double relaxation oscillation SQUID(DROS) sensor which was directly connected with a pickup coil. The neck space of LHe dewar was made to be smaller than that of a conventional dewar, but the LHe boil-off ratio appeared to increase. To reduce the temperature of low Tc SQUID sensor and pickup coil to 9 K, a metal shield made of, such as copper, brass or aluminum, have been usually used for thermal transmission. But the metal shield exhibited high thermal noise and eddy current fluctuation. We quantified the thermal noise and the eddy current fluctuation of metal. In this experiment, we used the bobbin which was made of an alumina to wind Nb superconductive wire for pickup coil and the average noise of coil-in-vacuum type MEG system was 3.5 fT/Hz1/2. Finally, we measured the auditory evoked signal to prove the reliability of coil-in-vacuum type MEG system.

  11. Report of the 1st technical meeting on high temperature gas-cooled reactors

    The 1st Technical Meeting on High Temperature Gas Cooled Reactors (HTGRs) was held on February 1 and 2, 1990 in the Tokai Research Establishment in order to review the results of R and D associated with the High Temperature Engineering Test Reactor (HTTR) accumulated so far in the JAERI and to investigate how to promote the further R and D on high temperature engineering and examination. From the point of view for establishing and upgrading the technology basis of HTGRs, the R and D results obtained so far and the present status of R and D were reviewed for the key items in the meeting, and the R and D items to be investigated positively and items of international cooperation to be promoted in future were discussed based on the comments and suggestions offered by the experts outside the JAERI. This report summarizes the papers which were presented on each subject of R and D in the meeting along with the comments and suggestions by the experts outside the JAERI. The results of the meeting will be reflected effectively for promoting the R and D on the high temperature engineering and examination. (author)

  12. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop: April 5-7, 2011

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: (1) Share the latest relevant knowledge among technical experts; (2) Review relevant state-of-the-art field measurement technologies and methods; (3) Review lessons learned from recent field deployments; (4) Identify synergies across different industries; (5) Identify gaps between existing and needed instrumentation capabilities; (6) Understand who are the leading experts; (7) Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  13. [POPIN Advisory Committee, 1st session. Geneva, March 22-25, 1982: report].

    1982-09-01

    A report of the POPIN, (International Population Information Network), Advisory Committee on its 1st session. The chairman presented a progress report on the activities of the Network in general and the POPIN coordinating unit in particular. More active participation by the developing countries was stressed to share information. The working group reported the efforts made by various groups for the translation of the population multilingual thesaurus into other languages. It also reviewed the draft manuscript on inventory and evaluation of training materials to identify gaps and make suggestions for improvement. The advisory committee suggested the development of a series of shorter guides which would deal with specific subjects. The development of a common classification scheme was considered of utmost importance since it would facilitate the processing, retrieval and exchange of information. A proposed work plan for 1983 and 1984 was discussed. This included publication of the POPIN Bulletin and newsletter, preparation of documentations for the sessions of the Advisory Committee, publication of the specific guides and a directory of POPIN members. Recommendations of the committee included measures for expansion of membership, publication of Popline multilingual thesaurus and guides for specific subjects. The committee considered and adopted the recommendations. Annexes include, 1) list of participants, documents and agenda, 2) recommendations of the POPIN working group on the management of the population multilingual thesaurus, and 3) recommendations on the inventory and evaluation of teaching materials for population information services. PMID:12279381

  14. Addressing the Effects of Reciprocal Teaching on the Receptive and Expressive Vocabulary of 1st-Grade Students

    Mandel, Eliana; Osana, Helena P.; Venkatesh, Vivek

    2013-01-01

    This study evaluated the effects of Adapted Reciprocal Teaching (ART) on the receptive and expressive flight-word vocabulary of 1st-grade students. During ART, classroom interactions produced narrative contexts within which students assumed responsibility for applying new flight words in personally meaningful ways. Students in the control group…

  15. Italian research on Antarctic atmosphere: 1st workshop. Ricerche italiane sull'atmosfera antartica: 1o workshop

    Colacino, M. (ed.); Giovannelli, G. (ed.); Stefanutti, L. (ed.)

    1989-01-01

    The papers and reports, presented at this 1st workshop on 'Italian research on antarctic atmosphere', deal with several main topics: meteorology and climatology, aerosol and tropospheric clouds, planetary boundary layer, chemical-physic stratospheric property, aeronomy. They define the stage of development of Italian research in this area after 3 years of activity in Antarctica.

  16. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    Goh, Khoon Song Aloysius; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted by three teachers in the school. Results suggest, at 95 percent confidence level, significant improvement for concept of Newtons 1st Law while not so for Newtons 3rd Law. A Focus Group Discussion revealed students confirming the usefulness of the EJS model in visualizing the 1st Law while not so much for the 3rd Law. We speculate the design ideas for constant velocity motion in the computer model coupled with the PbI worksheet did allow for making sense and experiencing of the 1st Law, where traditional pen-paper represen...

  17. 78 FR 7781 - Filing Dates for the South Carolina Special Elections in the 1st Congressional District

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Filing Dates for the South Carolina Special Elections in the 1st Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special elections. SUMMARY: South Carolina...

  18. Enantioselective synthesis of epi-(+)-Sch 642305: observation of an interesting diastereoselection during RCM

    Mehta, Goverdhan; Shinde, Harish M

    2005-01-01

    In an approach towards the enantioselective total synthesis of the novel bioactive natural product Sch 642305, an unusual diastereoselection during the key RCM reaction, resulted in the synthesis of the 11-epi-isorner of Sch 642305.

  19. Epi-LASIK与Flap-free Epi-LASIK术后TGF-β 2和b-FGF的表达及其对Haze形成的影响研究%Research of TGF- β 2 and b-FGF's expression after Epi-LASIK and Flap-free Epi-LASIK on rabbit and discuss the influence on Haze

    向一旻; 杜之渝; 刘玺; 黄正; 赵武校

    2009-01-01

    目的 观察比较Haze形成过程中的两个主要调控因子TGF-β和b-FGF,在兔Epi-LASIK与Flap-free Epi-LASIK术后表达有否差异,并探讨其对术后Haze形成的影响.方法 选用18只实验兔,建立兔Flap-free Epi-LASIK、Epi-LASIK模型,用VISX20/20B准分子激光仪作-10D切削,在无任何药物干预的情况下观察术后1、2、3月角膜Haze情况及检测比较角膜TGF-β2和b-FGF的表达水平,并探讨其对Haze形成的影响.结果 裂隙灯下观察Haze分级水平在术后1月、2月、3月差异均无统计学意义.Flap-free Epi-LASIK和Epi-LASIK术后1、2、3月TGF-β2表达差异没有统计学意义,且表现出逐渐降低的趋势.术后各时间点b-FGF表达组间比较差异无统计学意义,组内比较,b-FGF表达水平均呈现出持续升高的特点.结论 Epi-LASIK与Flap-free Epi-LASIK术后各时间点TGF-β2和b-FGF的表达情况及Haze发生程度均未见明显差异.%Objective To observe and compare the main control factor TGF-β 2 and b-FGF's expres-sion after the operation Epi-LASIK and Flap-free Epi-LASIK on rabbit during the process of Haze forming and discuss the influence on Haze forming after the operation. Methods 18 rabbits are established as Flap-free Epi-LASIK、Epi-LASIK models.Do-10D artherectomy with VISX20/20B.Then observe the Haze of 1、2、3m cornea under the situation without any drug intervention niter operation.Test and compare cornea TGF-β 2 and b-FGF expression and discuss its influence on Haze forming. Results It shows that there is no statistic mean-ing of the discrepancy of Haze after 1 month, 2 months and 3 months observing with slit lamp.The expression discrepancy of 1、2、3mTGF-β 2 niter Flap-free Epi-LASIK & Epi-LASIK is also no statistic meaning,and it presents falling trend.On each time point niter operation, comparing of each b-FGF, the discrepancy is no statis-tic meaning.Comparing in group,the expression of b-FGF presents rising trend. Conclusion There is no obvi

  20. Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.

    Yenjai, Chavi; Wanich, Suchana

    2010-05-01

    Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively. PMID:20362442

  1. Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells

    Peggy Matz

    2015-11-01

    Full Text Available Human umbilical vein endothelial cells (HUVECs were used to generate the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro. The transcriptome profile of epiHUVEC and the human embryonic stem cell line — H1 have a Pearson correlation of 0.899.

  2. EpiCollect+: linking smartphones to web applications for complex data collection projects.

    Aanensen, David M; Huntley, Derek M; Menegazzo, Mirko; Powell, Chris I; Spratt, Brian G

    2014-01-01

    Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry), whereas many applications require a more complex structure, allowing users to link a series of forms in a linear or branching hierarchy, along with the addition of any number of media types accessible from smartphones and/or tablet devices (e.g., GPS, photos, videos, sound clips and barcode scanning). A much enhanced version of EpiCollect has been developed (EpiCollect+). The individual data collection forms in EpiCollect+ provide more design complexity than the single form used in EpiCollect, and the software allows the generation of complex data collection projects through the ability to link many forms together in a linear (or branching) hierarchy. Furthermore, EpiCollect+ allows the collection of multiple media types as well as standard text fields, increased data validation and form logic. The entire process of setting up a complex mobile phone data collection project to the specification of a user (project and form definitions) can be undertaken at the EpiCollect+ website using a simple 'drag and drop' procedure, with visualisation of the data gathered using Google Maps and charts at the project website. EpiCollect+ is suitable for situations where multiple users transmit complex data by mobile phone (or other Android devices) to a single project web database and is already being used for a range of field projects, particularly public health projects in sub-Saharan Africa. However, many uses can be envisaged from education, ecology and epidemiology to citizen science. PMID:25485096

  3. A simple design rule for 1st order form-closure of underactuated hands

    S. Krut

    2011-02-01

    Full Text Available The property of form-closure of a grasp, as generally defined in the literature, is based on the assumption that contact points between the hand and the object are fixed in space. However, this assumption is false when considering a grasp exerted by an underactuated hand, since in this case, it is not possible to control the position of each phalanx independently. In spite of researchers' interest in studying form-closure, none of the available published work on this subject takes into consideration the particular kinematics of underactuated hands. Actually, there are few available tools to qualify or quantify the stability of a grasp exerted by an underactuated hand, thus the design of underactuated hands mostly results from an intuitive approach. This paper aims to reduce this gap.

    A classification of underactuated hands is proposed, based on the expression of contact forces. This highlights the influence of non-backdrivable mechanisms introduced in the transmission of the closing motion of the hand on the stability of the grasp. The way to extend the original definition of form-closure to underactuated grasps is illustrated. A more general definition is formulated, which checks the stability of the set "object + hand". Using this new definition, a simple rule is proposed for designing a hand capable of achieving 1st order form-closed grasps.

    This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010, 19 August 2010, Montréal, Canada.

  4. PREFACE: 1st Conference on Light and Particle Beams in Materials Science 2013 (LPBMS2013)

    Kumai, Reiji; Murakami, Youichi

    2014-04-01

    From 29-31 August 2013, the 1st International Conference on Light and Particle Beams in Materials Science, LPBMS 2013, took place in the Tsukuba International Congress Center in the city of Tsukuba, Japan. The conference was a continuation of the international series Synchrotron Radiation in Materials Science (SRMS), which started in 1994. The last one, SRMS-7, was held in Oxford UK 11-14 July 2010, where the International Advisory Committee (IAC) recommended the conference be enlarged to incorporate Materials Research from Neutron, Muon, and Slow Positron Sources, as well as the science emerging from Synchrotron Light Sources. The conference brought together contributions from academics and industrial researchers with a diverse background and experience from the physics, chemistry and engineering communities. The topics covered in the LPBMS2013 include strongly correlated electron systems, magnetism and magnetic materials, soft matter, interface and surface defects, catalysts, biomaterials, and ceramics. In the 3-day scientific program, the conference consisted of 9 plenary talks, 33 invited talks, 20 oral presentations, and 126 poster presentations. We are pleased to publish the proceedings of the LPBMS2013 in this volume of Journal of Physics: Conference Series. This volume contains 58 papers representing the work that was presented and discussed at the conference. We hope that this volume will promote further development of this interdisciplinary materials research emerging from synchrotron light, neutron, muon, and slow positron sciences. Finally, we would like to thank the International Advisory Committee (Chair: Professor G N Greaves), sponsors, all the participants and contributors for making possible this international meeting of researchers. Reiji Kumai & Youichi Murakami Conference photograph Details of the program and organizing committees are available in the pdf

  5. Patterns of Irregular Burials in Western Europe (1st-5th Century A.D.)

    Milella, Marco; Mariotti, Valentina; Belcastro, Maria Giovanna; Knüsel, Christopher J.

    2015-01-01

    Background Irregular burials (IB—burials showing features that contrast with the majority of others in their geographic and chronological context) have been the focus of archaeological study because of their relative rarity and enigmatic appearance. Interpretations of IB often refer to supposed fear of the dead or to social processes taking place in time-specific contexts. However, a comprehensive and quantitative analysis of IB for various geographical contexts is still lacking, a fact that hampers any discussion of these burials on a larger scale. Methods Here, we collected a bibliographic dataset of 375 IB from both Britain and Continental Europe, altogether spanning a time period from the 1st to the 5th century AD. Each burial has been coded according to ten dichotomous variables, further analyzed by means of chi-squared tests on absolute frequencies, non-metric multidimensional scaling, and cluster analysis. Results Even acknowledging the limits of this study, and in particular the bias represented by the available literature, our results point to interesting patterns. Geographically, IB show a contrast between Britain and Continental Europe, possibly related to historical processes specific to these regions. Different types of IB (especially prone depositions and depositions with the cephalic extremity displaced) present a series of characteristics and associations between features that permit a more detailed conceptualization of these occurrences from a socio-cultural perspective that aids to elucidate their funerary meaning. Conclusions and Significance Altogether, the present work stresses the variability of IB, and the need to contextualize them in a proper archaeological and historical context. It contributes to the discussion of IB by providing a specific geographic and chronological frame of reference that supports a series of hypotheses about the cultural processes possibly underlying their occurrence. PMID:26115408

  6. After Meeting: The 1st Maritime Pilotage/Towage Services and Technologies Congress

    Adnan PARLAK

    2016-03-01

    Full Text Available The 1st Maritime Pilotage/Towage Services and Technologies Congress has been organized by UCTEA Chambers of Marine Engineers, UCTEA the Chamber of Turkish Naval Architects & Marine Engineers and Turkish Maritime Pilots’ Association at 23 October 2015, Hilton Hotel, İzmir. In the opening ceremony, two distinguished keynote speakers have presented their presentations. Captain Stein Inge DAHN who is the president of European Maritime Pilots’ Association(EMPA has given a fulfilling speech on switching to hand steering by giving an example from the automation in the Aviation Industry. The second keynote speaker Robert G. Allan, who is the Executive Chairman of Robert Allan Ltd., has given a leading speech under the title of “The State of the Art in Escort Tug Technology -2015”. Five key points have come into prominence during the symposium. To summarize: • To prevent ships and cargos which are exposed to damages, • To prevent marine and coastal environments against pollution due to collisions, • To establish fast, secure and well organized sea traffic • To develop new escort tug technologies and pilotage softwares in the national level which is open to competitions in the international markets. • Opening maritime pilotage into the competitions in the areas which needs special expertize. In my opinion, the topics discussed in the symposium have the attendants won a wide horizon in the field. However, the presentations related to Escort Tug Technologies were insufficient from the standpoint of both quality and numbers of the manuscripts presented. Due to importance of Maritime Pilotage/Towage Services and Technologies, much more attentions must be taken in the national and international levels and sustainability of the symposium must be provided .

  7. Curative observation of Epi-LASIK and LASIK for high myopia%Epi-LASIK和LASIK矫治高度近视的疗效比较

    吴登雷; 张芹; 潘晓英

    2012-01-01

    Objective: To explore curative effect after microkeratome excimer laser epithelial keratomile -usis (Epi-LASIK) and laser in situ keratomileusis (LASIK) for high myopia, and to evaluate the safety and efficacy of Epi-LASIK and LASIK. Methods; Used United States VISX StarS4 laser, and Moria flat push type micro corneal epithelial knife making corneal flap was used for Epi -LASIK, with 0. 02% mitomycin C sponge soaked in. LASIK used Moria rotating type corneal knife making 110 μm corneal flap. The patients was followed up more than 6 months, and compared postoperative symptoms , visual acuity, refraction, and so on. Results; One week postoperative ,the proportion of UCVA≥0. 8 of Epi-LASIK (47. 8% ) was less than LASIK (95.8%) , the difference was statistically significant (x2 =27.056, P = 0.000) ; no statisti-cally significant differences were found in those of Epi-LASIK(95. 7% , 97. 8% , 97. 8%) and LASIK (97. 9% , 97. 9% , 97. 9% ) after 1,3,6 months. After 1 week, the diopter difference was statistically sig-nificant (t = -7. 123 ,P = 0. 000) ; after 1,3,6 months the diopter difference was not statistically signifi -cant. Conclusion; LASIK was still the mainstream of current treatment of myopia . Epi-LASIK was an effective and safe procedure for high myopia. Although the recovery of visual acuity was slower than LASIK , it had a wide range of operation indication , its long-term efficacy still remains to be seen.%目的:比较微型角膜刀准分子激光角膜上皮瓣下磨镶术(Epi-LASIK)与准分子激光原位角膜磨镶术(LASIK)矫治高度近视的疗效.评估两种术式的安全性和有效性.方法:采用美国VISX StarS4激光机,Epi-LASIK组采用Moria平推型微型角膜上皮刀制作角膜上皮瓣,用浸有0.02%丝裂霉素C的海绵片,LASIK组采用Moria旋转型角膜板层刀制作110 μm厚度角膜瓣.随访6月以上,对两组术后症状、视力、屈光等进行比较.结果:术后1周Epi-LASIK组裸眼视力(uncorrected visual

  8. Performance of EPI diodes as dosimeters for photon beam radiotherapy

    Santos, Thais C. dos; Bizetto, Cesar A., E-mail: ccbueno@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Neves-Junior, Wellington F.P.; Haddad, Cecilia M.K. [Hospital Sirio Libanes (HSL), Sao Paulo, SP (Brazil); Goncalves, Josemary A.C.; Bueno, Carmen C. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Pontificia Universidade Catolica de Sao Paulo (PUC-SP), SP (Brazil)

    2011-07-01

    In this work we present the preliminary results about the performance of an epitaxial (EPI) diode as on-line dosimeter for photon beam radiotherapy. The diode used was processed at University of Hamburg on n-type 75 {mu}m thick epitaxial silicon layer grown on a highly doped n-type 300 {mu}m thick Czochralski (Cz) silicon substrate. The measurements were performed with a diode which not received any type of pre-dose. In order to use this device as a dosimeter, it was enclosed in a black polymethylmethacrylate (PMMA) probe. The diode was connected to an electrometer Keithley 6517B in the photovoltaic mode. During all measurements, the diode was held between PMMA plates, placed at 10.0 cm depth and centered in a radiation field of 10 x 10 cm{sup 2}, with the source-to-surface distance (SSD) kept at 100 cm. The short-term repeatability was measured with photon beams of 6 and 18 MV energy by registering five consecutive current signals for the same radiation dose. The current signals induced showed good instantaneous repeatability of the diode, characterized by a smallest coefficient of variation (CV) of 0.21%. Furthermore, the dose-response curves of the diode were quite linear with the highest charge sensitivity achieved of 5.0 {mu}C/Gy. It worth noting that still remains to be investigated the pre-dose influence on epitaxial silicon diode response in radiotherapy photon beam dosimetry, the long term stability and the radiation hardness of these diodes for absorbed doses higher than that investigated in this work. All these studies are under way. (author)

  9. Epi-LASIK和去瓣Epi-LASIK治疗中高度近视的临床疗效比较%Clinical comparison of Epi-LASIK and off-flap Epi-LASIK for the treatment of moderate to high myopia

    孙丽霞; 宋跃; 张日平; 熊露; 凌安妮; 刘彩霞; 王贤

    2012-01-01

    Objective To compare the postoperative course and the clinical results of off-flap Epi-LASIK and Epi-LASIK for the treatment of moderate to high myopia for 1 year. Methods Corneal epithelial flaps of 28 patients with moderate to high myopia were separated with an Amadeus II epikeratome.A patient's eye was randomly treated with flap-off Epi-LASIK.The other eye was underwent Epi-LASIK.All patients' corneal stroma was ablated by TECHNOLAS 217Z100 excimer laser.Pain scores,pain time and uncorrected visual acuity (UCVA) were evaluated at the 4 to 7 days after surgery.UCVA,spherical equivalent,best corrected visual acuity (BCVA) and haze scores were recorded at 2 weeks,1 month,3 months,6 months and 1 year after surgery. Results The mean preoperative spherical equivalent of Epi-LASIK and flap-off Epi-LASIK were-7.39±2.21D and -7.69±2.38D,P =0.12.Compared with the Epi-LASIK eyes,the better UCVA at 4 or 5 and 14 days after surgery (P =0.01,0.046) and the lower pain scores (P =0.049) were found in off-flap Epi-LASIK eyes.Painful time had no significant difference between 2 groups.There was no significant difference between the 2 groups at the other postoperative intervals in terms of spherical equivalent and UCVA.There was no significant between-group difference in the change in lines of BCVA at 1 year after surgery.The lower level of haze scores at 2 weeks and 3 months after surgery (P=0.00,0.01) were found in off-flap Epi-LASIK eyes. Conclusions Off-flap Epi-LASIK offers the less postoperative pain,the lower level of haze formation and a faster visual recovery speed than Epi-LASIK for the treatment of moderate to high myopia.%目的 比较去瓣Epi-LASIK和Epi-LASIK治疗中高度近视的术后病程和1年的临床结果.方法 使用Amadeus Ⅱ角膜上皮刀分离28位中高度近视病人的角膜上皮瓣.随机选择病人的一只眼接受去瓣Epi-LASIK;另一只眼接受Epi-LASIK.使用TECHNOLAS 217Z100准分子激光机切削角膜基质.术后4至7天询

  10. Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium

    Ellis, Matthew; Gillette, Michael; Carr, Steven A.; Paulovich, Amanda G.; Smith, Richard D.; Rodland, Karin D.; Townsend, Reid; Kinsinger, Christopher; Mesri, Mehdi; Rodriguez, Henry; Liebler, Daniel

    2013-10-03

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verifi cation using targeted mass spectrometry methods.

  11. Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)

    En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science

  12. 78 FR 69426 - Submission for OMB Review; 30-Day Comment Request: NIH NCI Central Institutional Review Board...

    2013-11-19

    ... review. The benefits to the National Clinical Trials Network and Experimental Therapy-Clinical Trials... for Participants 25 1 2 50 Treatment Studies. NCI Adult/Pediatric CIRB Application for Participants 10... National Cancer Institute (NCI), National Institutes of Health, may not conduct or sponsor, and...

  13. Adaptive and Effortful Control and Academic Self-Efficacy Beliefs on Achievement: A Longitudinal Study of 1st through 3rd Graders

    Liew, Jeffrey; McTigue, Erin M.; Barrois, Lisa; Hughes, Jan N.

    2008-01-01

    The linkages between self-regulatory processes and achievement were examined across 3 years in 733 children beginning at 1st grade (M = 6.57 years, S.D. = 0.39 at 1st grade) who were identified as lower achieving in literacy. Accounting for consistencies in measures (from 1 year prior) and for influences of child's age, gender, IQ, ethnicity and…

  14. Effects of the April 1st, 2014 GLONASS Outage on GNSS Receivers

    Blume, F.; Berglund, H. T.; Romero, I.; D'Anastasio, E.

    2014-12-01

    The use of multi-constellation GNSS receivers has been assumed as a way to increase system integrity both by increased coverage during normal operations and failover redundancy in the event of a constellation failure. At approximately 21:00 UTC on April 1st the entire GLONASS constellation was disrupted as illegal ephemeris uploaded to each satellite took effect simultaneously. The outage continued for more than 10 hours. While ephemeris were incorrect, pseudoranges were correctly broadcast on both L1 and L2 and carrier phases were not affected; in the best case, GNSS receivers could be expected to continue to track all signals including GLONASS and at the worst to continue to track GPS and other constellations. It became clear to operators of the GeoNet network in New Zealand that the majority of their 79 GLONASS-enabled receivers experienced total tracking failures. Further detailed analysis of data from these and 315 additional GLONASS-enabled stations worldwide showed that receiver tracking behavior was affected for most receiver brands and models, both for GLONASS and GPS. Findings regarding the impacts of the GLONASS outage on receiver behavior will be highlighted. We use data recorded by GLONASS enabled global sites for the days during, preceding and following the outage to evaluate the impact of the outage on tracking and positioning performance. We observe that for some receiver types the onboard receiver autonomous integrity monitoring (RAIM) failed to ignore the incorrect messages, resulting in degraded GLONASS and GPS tracking and in some cases complete tracking failures and significant data loss. In addition, many of the receivers with clock steering enabled showed outliers in their receiver clock bias estimates that also coincided with the outage. Our results show in detail how different brands, configurations, and distributions of receivers were affected to varying extents, but no common factors are apparent. This event shows that many manufacturers

  15. PREFACE: 1st International Conference on Mechanical Engineering Research 2011 (ICMER2011)

    Abu Bakar, Rosli

    2012-09-01

    The year 2010 represented a significant milestone in the history of the Mechanical Engineering community with the organization of the first and second national level conferences (National Conference in Mechanical Engineering for Research, 1st and 2nd NCMER) at Universiti Malaysia Pahang on 26-27 May and 3-4 December 2010. The conferences attracted a large number of delegates from different premier academic and research institutions in the country to participate and share their research experiences at the conference. The International Conference on Mechanical Engineering Research (ICMER 2011) followed on from the first and second conferences due to good support from researchers. The ICMER 2011 is a good platform for researchers and postgraduate students to present their latest finding in research. The conference covers a wide range of topics including the internal combustion engine, machining processes, heat and mass transfer, fuel, biomechanical analysis, aerodynamic analysis, thermal comfort, computational techniques, design and simulation, automotive transmission, optimization techniques, hybrid electric vehicles, engine vibration, heat exchangers, finite element analysis, computational fluid dynamics, green energy, vehicle dynamics renewable energy, combustion, design, product development, advanced experimentation techniques, to name but a few. The international conference has helped to bridge the gap between researchers working at different institutions and in different countries to share their knowledge and has helped to motivate young scientists with their research. This has also given some clear direction for further research from the deliberations of the conference. Several people have contributed in different ways to the success of the conference. We thank the keynote speakers and all authors of the contributed papers, for the cooperation rendered to us in the publication of the CD conference proceedings. In particular, we would like to place on record our

  16. PREFACE: 1st-2nd Young Researchers Meetings in Rome - Proceedings

    YRMR Organizing Committee; Cannuccia, E.; Mazzaferro, L.; Migliaccio, M.; Pietrobon, D.; Stellato, F.; Veneziani, M.

    2011-03-01

    Students in science, particularly in physics, face a fascinating and challenging future. Scientists have proposed very interesting theories, which describe the microscopic and macroscopic world fairly well, trying to match the quantum regime with cosmological scales. Between the extremes of this scenario, biological phenomena in all their complexity take place, challenging the laws we observe in the atomic and sub-atomic world. More and more accurate and complex experiments have been devised and these are now going to test the paradigms of physics. Notable experiments include: the Large Hadronic Collider (LHC), which is going to shed light on the physics of the Standard Model of Particles and its extensions; the Planck-Herschel satellites, which target a very precise measurement of the properties of our Universe; and the Free Electron Lasers facilities, which produce high-brilliance, ultrafast X-ray pulses, allowing the investigation of the fundamental processes of solid state physics, chemistry, and biology. These projects are the result of huge collaborations spread across the world, involving scientists belonging to different and complementary research fields: physicists, chemists, biologists and others, keen to make the best of these extraordinary laboratories. Even though each branch of science is experiencing a process of growing specialization, it is very important to keep an eye on the global picture, remaining aware of the deep interconnections between inherent fields. This is even more crucial for students who are beginning their research careers. These considerations motivated PhD students and young post-docs connected to the Roman scientific research area to organize a conference, to establish the background and the network for interactions and collaborations. This resulted in the 1st and 2nd Young Researchers Meetings in Rome (http://ryrm.roma2.infn.it), one day conferences aimed primarily at graduate students and post-docs, working in physics in Italy

  17. PREFACE: 1st International Conference on Sensing for Industry, Control, Communication & Security Technologies

    Shuja Syed, Ahmed

    2013-12-01

    The 1st International Conference on Sensing for Industry, Control, Communication & Security Technologies (ICSICCST-2013), took place in Karachi, Pakistan, from 24-26 June 2013. It was organized by Indus University, Karachi, in collaboration with HEJ Research Institute of Chemistry, University of Karachi, Karachi. More than 80 abstracts were submitted to the conference and were double blind-reviewed by an international scientific committee. The topics of the Conference were: Video, Image & Voice Sensing Sensing for Industry, Environment, and Health Automation and Controls Laser Sensors and Systems Displays for Innovative Applications Emerging Technologies Unmanned, Robotic, and Layered Systems Sensing for Defense, Homeland Security, and Law Enforcement The title of the conference, 'Sensing for Industry, Control, Communication & Security Technologies' is very apt in capturing the main issues facing the industry of Pakistan and the world. We believe the sensing industry, particularly in Pakistan, is currently at a critical juncture of its development. The future of the industry will depend on how the industry players choose to respond to the challenge of global competition and opportunities arising from strong growth in the Asian region for which we are pleased to note that the conference covered a comprehensive spectrum of issues with an international perspective. This will certainly assist industry players to make informed decisions in shaping the future of the industry. The conference gathered qualified researchers from developed countries like USA, UK, Sweden, Saudi Arabia, China, South Korea and Malaysia etc whose expertise resulting from the research can be drawn upon to build an exploitable area of new technology that has potential Defense, Homeland Security, and Military applicability. More than 250 researchers/students attended the event and made the event great success as the turnout was 100%. An exceptional line-up of speakers spoke at the occasion. We want

  18. Coronal MR imaging of the normal 3rd, 4th, and 5th lumbar and 1st sacral nerve roots

    Seven healthy volunteers underwent coronal MR imaging at 1.5 tesla of the normal 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots. Coronal slices, 3-mm-thick with a 0.3-mm gap between the slices were obtained (TR/TE 600/22) through the lumbar spinal canal. All the nerve roots were visible on at least one image. One can routinely expect to demonstrate the 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots on T1-weighted, 3-mm-thick coronal MR scans. We found no correlation between the degree of lumbar lordosis and the lengths of the visible nerve roots. Five patients with one of the following spinal problems: anomaly, tumor, disk herniation, and failed back surgery syndrome were examined according to our protocol. In all these cases coronal MR imaging gave the correct diagnosis. (orig.)

  19. The analysis of functional capacity of people with tetraplegia during the 1st level of the Active Rehabilitation camp.

    Jozefowsky Peter

    2011-08-01

    Full Text Available The aim of the study was to analyze functional capacity during the 1st level of the Active Rehabilitation camp of people after spinal cord injury (SCI in cervical segment. The individual functional indicators as: self-service, sphincter control, mobility, locomotion and communication have been analyzed. The study included 30 men with SCI in cervical segment and in age of 18-45. The clinimetric scale for functional rating of neurological patients - The Functional Indicator "Repty" was used in the study. The test were conducted twice: immediately before the beginning of the camp and after. An improvement in functional capacity occurred among all respondents during the 1st level of the AR camp. The greatest improvements concerned the mobility and self-service, smaller improvement occurred in locomotion and sphincter control. There was no significant improvement in level of communication.

  20. Coronal MR imaging of the normal 3rd, 4th, and 5th lumbar and 1st sacral nerve roots

    Hald, J.K.; Nakstad, P.H.; Hauglum, B.E. (National Hospital, Oslo (Norway). Dept. of Radiology)

    1991-05-01

    Seven healthy volunteers underwent coronal MR imaging at 1.5 tesla of the normal 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots. Coronal slices, 3-mm-thick with a 0.3-mm gap between the slices were obtained (TR/TE 600/22) through the lumbar spinal canal. All the nerve roots were visible on at least one image. One can routinely expect to demonstrate the 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots on T1-weighted, 3-mm-thick coronal MR scans. We found no correlation between the degree of lumbar lordosis and the lengths of the visible nerve roots. Five patients with one of the following spinal problems: anomaly, tumor, disk herniation, and failed back surgery syndrome were examined according to our protocol. In all these cases coronal MR imaging gave the correct diagnosis. (orig.).

  1. Teachers' Spatial Anxiety Relates to 1st-and 2nd-Graders' Spatial Learning

    Gunderson, Elizabeth A.; Ramirez, Gerardo; Beilock, Sian L.; Levine, Susan C.

    2013-01-01

    Teachers' anxiety about an academic domain, such as math, can impact students' learning in that domain. We asked whether this relation held in the domain of spatial skill, given the importance of spatial skill for success in math and science and its malleability at a young age. We measured 1st-and 2nd-grade teachers' spatial anxiety…

  2. Multi-objective Optimization of a Solar Assisted 1st and 2nd Generation Sugarcane Ethanol Production Plant

    Zevenhoven, Ron; Wallerand, Anna Sophia; Queiroz Albarelli, Juliana; Viana Ensinas, Adriano; Ambrosetti, Gianluca; Mian, Alberto; Maréchal, François

    2014-01-01

    Ethanol production sites utilizing sugarcane as feedstock are usually located in regions with high land availability and decent solar radiation. This offers the opportunity to cover parts of the process energy demand with concentrated solar power (CSP) and thereby increase the fuel production and carbon conversion efficiency. A plant is examined that produces 1st and 2nd generation ethanol by fermentation of sugars (from sugarcane) and enzymatic hydrolysis of the lignocellulosic residues (bag...

  3. Summary Report of 1st Research Coordination Meeting on Development of Reference Database for Beta-delayed Neutron Emission

    A summary is given of the 1st Research Coordination Meeting of the new IAEA Coordinated Research Project (CRP) on Development of a Reference Database for Beta-delayed neutron emission data. Participants presented their work, reviewed the current status of the field with regards to individual precursors and aggregate data, and discussed the scope of the work to be undertaken. A list of priorities and task assignments was produced. (author)

  4. Bounding information and media frontiers: short papers [de] SIACG 2002 - 1st Ibero-American Symposium in Computer Graphics

    Santos, Próspero dos; Jorge, Joaquim; Marcos, Adérito

    2002-01-01

    This is the book of short papers of the 1st Ibero-American Symposium in Computer Graphics (SIACG) which was the first in a series of similar events organised every year, alternating between Europe and South America. Its mission is to foster transatlantic co-operation through the exchange of scholars, ideas, information and participation in joint projects between Computer Graphics communities in the Iberian Peninsula and Latin America.

  5. Nuclear Physics Department: Progress report from the 1st October 1988 to the 30th September 1990

    The work performed at the Nuclear Physics Department, from the 1st October 1988 to the 30th September 1990, are summarized. The investigations are carried out in the fields of heavy ion physics, intermediate energy physics and accelerators using superconducting cavities. Theoretical and experimental studies accomplished in the following fields are included: hot nuclei, exotic nuclei, giant resonances, fission, inelastic scattering, electroproduction of pions, polarization of deuterons, central collisions

  6. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    Velusamy, Nithya

    2014-03-20

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  7. (Update) HIV Conference to Be Held on February 25 at NCI at Frederick | Poster

    By Anne Arthur, Guest Writer The HIV Drug Resistance Program (HIV DRP), Center for Cancer Research (CCR), will hold a conference on “Host Factors and Cofactors in HIV Infection” at the National Cancer Institute (NCI) campus in Frederick, Md., on Feb. 25, from 1:00 to 5:35 p.m.

  8. HIV Conference to Be Held on October 21 at NCI at Frederick | Poster

    By Anne Arthur, Guest Writer The HIV Drug Resistance Program Conference on “Virus Structure: Putting the Pieces Together” will be held at NCI at Frederick on October 21, 2014, from 1:00 to 5:45 p.m. in the Conference Center auditorium, Building 549.

  9. Treatment of Prostate Cancer using Anti-androgen Small Molecules | NCI Technology Transfer Center | TTC

    The National Cancer Institute seeks parties interested in collaborative research to co-develop and commercialize a new class of small molecules for the treatment of prostate cancer. General information on co-development research collaborations, can be found on our web site (http://ttc.nci.nih.gov/forms).

  10. Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.

    Chen, Chun-Jen; Hsu, Mei-Hua; Huang, Li-Jiau; Yamori, Takao; Chung, Jing-Gung; Lee, Fang-Yu; Teng, Che-Ming; Kuo, Sheng-Chu

    2008-01-15

    As part of a continuing search for potential anticancer drug candidates, 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) was evaluated in the Japanese Cancer Institute's (JCI) in vitro disease-oriented anticancer screen. The results indicated that YC-1 showed impressive selective toxicity against the NCI-H226 cell line. Therefore, the molecular mechanism by which YC-1 affects NCI-H226 cell growth was studied. YC-1 inhibited NCI-H226 cell growth in a time- and a concentration-dependent manner. YC-1 suppressed the protein levels of cyclin D1, CDK2 and cdc25A, up-regulated p16, p21 and p53, increased the number of NCI-H226 cells in the G0/G1 phase of the cell cycle. Long exposure to YC-1 induced apoptosis by mitochondrial-dependent pathway. In addition, YC-1 inhibited MMP-2 and MMP-9 protein activities to abolish tumor cells metastasis. These findings suggest a mechanism of cytotoxic action of YC-1 and indicate that YC-1 may be a promising chemotherapy agent against lung cancer. PMID:17880926

  11. 76 FR 22714 - Proposed Collection; Comment Request; Health Information National Trends Survey 4 (HINTS 4) (NCI)

    2011-04-22

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; Health Information... understand vital cancer prevention messages. More importantly, this NCI survey will couple knowledge-related.... Average time Data collection cycle Type of Number of Frequency of per response Annual hour...

  12. Novel Diagnostic Marker for Improving Treatment Outcomes of hepatitis C | NCI Technology Transfer Center | TTC

    The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG) Immunoepidemiology Branch is seeking statements of capability or interest from parties interested in collaborative research to further co-develop a gene-based diagnostic for Hepatitis C virus (HepC, HCV).

  13. Se lanza Red Nacional de Estudios Clínicos del NCI

    El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

  14. Protein Profile of Human Lung Squamous Carcinoma Cell Line NCI-H226

    HAO ZHANG; NA LI; YUE CHEN; LING-YUN HUANG; YI-CHING WANG; GANG FANG; DA-CHENG HE; XUE-YUAN XIAO

    2007-01-01

    Objective To construct a database of human lung squamous carcinoma cell line NCI-H226 and to facilitate discovery of novel subtypes markers of lung cancer. Method Proteomic technique was used to analyze human lung squamous carcinoma cell line NCI-H226. The proteins of the NCI-H226 cells were separated by two-dimensional gel electrophoresis and identified by mass spectrometry. Results The results showed that a good reproducibility of the 2-D gel pattern was attained. The position deviation of matched spots among three 2-D gels was 1.95±0.53 mm in the isoelectric focusing direction,and 1.73±0.45 mm in the sodium dodecyl sulfate-polyacrylamide gel electrophoresis direction. One hundred and twenty-seven proteins, including enzymes, signal transduction proteins, structure proteins, transport proteins, etc. were characterized, of which, 29 identified proteins in NCI-H226 cells were reported for the first time to be involved in lung cancer carcinogenesis.Conclusion The information obtained from this study could provide some valuable clues for further study on the carcinogenetic mechanism of different types of lung cancer, and may help us to discover some potential subtype-specific biomarkers of lung cancer.

  15. Preoperative and Postoperative (1st and 3rd Month Metabolic Data of Patients Who Underwent Bariatric Surgery

    Nilüfer Özdemir Kutbay

    2015-03-01

    Full Text Available Purpose: The growing prevalence of obesity has become a major concern. The efficacy of medical treatment, diet and behavior therapy in morbidly obese patients is limited. Obesity surgery is a treatment option for selected morbidly obese patients. Material and Method: Data of 47 patients (n=39 women, 8 men who underwent bariatric surgery were investigated. Results: Out of 47 patients, 20 underwent Roux-en-Y gastric bypass (RYGB (43% and 27 had sleeve gastrectomy (SG (57%. The mean age of the patients was 37±9.5 (19-59 years. 17% of patients were men and 83% were women. In the analysis of data on weight that could be found for 31 out of 47 patients, we detected preoperative and postoperative (1st and 3rd month mean weight values as 125.4±15.9 kg, 112.7±13.2 kg (p<0.001 and 100.9±17.5 kg (p<0.001, respectively. In addition, the analysis of the data on mean fasting plasma glucose (FPG levels which could be found for 23 out of 47 patients, showed us that preoperative and postoperative (1st and 3rd month FPG levels were 100.9±17.5 mg/dL, 91.6±10.9 mg/dL (p=0.03 and 87.3±2.0 mg/dL, respectively. Only 1 patient had diabetes before the surgery. In the RYGB group, the mean change in weight was 12.4±5.5 kg in the 1st month and 22.2±8.6 kg in the 3rd month (compared to the weights in the preoperative period. Moreover, in the SG group, the mean change in weight was 13.7±4.5 kg in the 1st month and 23.4±5.8 kg in the 3rd month. No statistically significant difference was found between the weight changes in the 1st and the 3rd month as for surgery types. Discussion: After bariatric surgery, significant loss in weight and reduction in FPG occurred in short-term.

  16. EpiJen: a server for multistep T cell epitope prediction

    Guan Pingping

    2006-03-01

    Full Text Available Abstract Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP to the endoplasmic reticulum (ER, where peptides are bound by MHC class I molecules, and then presented on the cell surface by MHCs. The whole process is modeled here using an integrated approach, which we call EpiJen. EpiJen is based on quantitative matrices, derived by the additive method, and applied successively to select epitopes. EpiJen is available free online. Results To identify epitopes, a source protein is passed through four steps: proteasome cleavage, TAP transport, MHC binding and epitope selection. At each stage, different proportions of non-epitopes are eliminated. The final set of peptides represents no more than 5% of the whole protein sequence and will contain 85% of the true epitopes, as indicated by external validation. Compared to other integrated methods (NetCTL, WAPP and SMM, EpiJen performs best, predicting 61 of the 99 HIV epitopes used in this study. Conclusion EpiJen is a reliable multi-step algorithm for T cell epitope prediction, which belongs to the next generation of in silico T cell epitope identification methods. These methods aim to reduce subsequent experimental work by improving the success rate of epitope prediction.

  17. Reduction of gradient acoustic noise in MRI using SENSE-EPI.

    de Zwart, Jacco A; van Gelderen, Peter; Kellman, Peter; Duyn, Jeff H

    2002-08-01

    A new approach to reduce gradient acoustic noise levels in EPI experiments is presented. Using multichannel RF receive coils, combined with SENSE data acquisition and reconstruction, gradient slew-rates in single-shot EPI were reduced fourfold for rate-2 and ninefold for rate-3 SENSE. Multislice EPI experiments were performed on three different scanner platforms. With 3.4 mm in-plane resolution, measuring 6 slices per second (12 slices with 2000 ms TR), this resulted in average sound pressure level reductions of 11.3 dB(A) and 16.5 dB(A) for rate-2 and rate-3 SENSE, respectively. BOLD fMRI experiments, using visually paced finger-tapping paradigms, showed no detrimental effect of the acoustic noise reduction strategy on temporal noise levels and t scores. PMID:12202101

  18. Images by nuclear magnetic resonance. A modified version of the EPI method

    It is well known that data acquisition times and image reconstruction procedures in conventional magnetic resonance imaging (MRI) are usually long. For time dependent phenomena, such as sample motion, respiration, blood flow pulsation and others, faster acquisition times as desirable to avoid ghosting artifacts. Over the last two decades, a great number of fast and ultra-fast MRI methods have been proposed that greatly reduce the acquisition times. One of them is the echo-planar imaging (EPI) method which uses a single excitation scheme to scan entirely the k-space in a very short time. In the initial sections of this work we will supply the reader with a brief description of the image reconstruction procedures for the conventional MRI sequence and four different schemes of the EPI method. However, our main objective is to propose a modified version of the spin-echo EPI method, suggesting a sequence with the use of a constant phase encoding gradient. (author)

  19. Identification of Two Nickel Ion-Induced Genes, NCI16 and PcGST1, in Paramecium caudatum

    Takenaka, Yasuhiro; Haga, Nobuyuki; Inoue, Ikuo; Nakano, Takanari; Ikeda, Masaaki; Katayama, Shigehiro; Awata, Takuya

    2014-01-01

    Here, we describe the isolation of two nickel-induced genes in Paramecium caudatum, NCI16 and PcGST1, by subtractive hybridization. NCI16 encoded a predicted four-transmembrane domain protein (∼16 kDa) of unknown function, and PcGST1 encoded glutathione S-transferase (GST; ∼25 kDa) with GST and glutathione peroxidase (GPx) activities. Exposing cells to cobalt chloride also caused the moderate upregulation of NCI16 and PcGST1 mRNAs. Both nickel sulfate and cobalt chloride dose dependently indu...

  20. Intèrpret d'experiències interactives basades en geo-localització per a sistemes Android

    Pérez Sandonís, Jordi

    2015-01-01

    Aquest treball presenta l'intèrpret d'experiències interactives basades en geolocalització "Gien" pel sistema operatiu mòbil Android. "Gien" pretén interpretar i interactuar amb aquestes experiències de diferents caires i donar solució al problema dels desenvolupadors d'experiències que han de programar una aplicació diferent per a cadascuna d'elles. "Gien" és similar a un navegador web amb la diferència que aquesta aplicació no interpreta documents web sinó un altre tipus de fitxer que repre...

  1. Mapping three-dimensional oil distribution with π-EPI MRI measurements at low magnetic field

    Li, Ming; Xiao, Dan; Romero-Zerón, Laura; Marica, Florea; MacMillan, Bryce; Balcom, Bruce J.

    2016-08-01

    Magnetic resonance imaging (MRI) is a robust tool to image oil saturation distribution in rock cores during oil displacement processes. However, a lengthy measurement time for 3D measurements at low magnetic field can hinder monitoring the displacement. 1D and 2D MRI measurements are instead often undertaken to monitor the oil displacement since they are faster. However, 1D and 2D images may not completely reflect the oil distribution in heterogeneous rock cores. In this work, a high-speed 3D MRI technique, π Echo Planar Imaging (π-EPI), was employed at 0.2 T to monitor oil displacement. Centric scan interleaved sampling with view sharing in k-t space was employed to improve the temporal resolution of the π-EPI measurements. A D2O brine was employed to distinguish the hydrocarbon and water phases. A relatively homogenous glass bead pack and a heterogeneous Spynie core plug were employed to show different oil displacement behaviors. High quality 3D images were acquired with π-EPI MRI measurements. Fluid quantification with π-EPI compared favorably with FID, CPMG, 1D-DHK-SPRITE, 3D Fast Spin Echo (FSE) and 3D Conical SPRITE measurements. π-EPI greatly reduced the gradient duty cycle and improved sensitivity, compared to FSE and Conical SPRITE measurements, enabling dynamic monitoring of oil displacement processes. For core plug samples with sufficiently long lived T2, T2∗, π-EPI is an ideal method for rapid 3D saturation imaging.

  2. CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

    Reinhold William C

    2009-06-01

    Full Text Available Abstract Background Advances in the high-throughput omic technologies have made it possible to profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. A persistent problem is that some classes of molecular data are labeled with gene identifiers, others with transcript or protein identifiers, and still others with chromosomal locations. What has lagged behind is the ability to integrate the resulting data to uncover complex relationships and patterns. Those issues are reflected in full form by molecular profile data on the panel of 60 diverse human cancer cell lines (the NCI-60 used since 1990 by the U.S. National Cancer Institute to screen compounds for anticancer activity. To our knowledge, CellMiner is the first online database resource for integration of the diverse molecular types of NCI-60 and related meta data. Description CellMiner enables scientists to perform advanced querying of molecular information on NCI-60 (and additional types through a single web interface. CellMiner is a freely available tool that organizes and stores raw and normalized data that represent multiple types of molecular characterizations at the DNA, RNA, protein, and pharmacological levels. Annotations for each project, along with associated metadata on the samples and datasets, are stored in a MySQL database and linked to the molecular profile data. Data can be queried and downloaded along with comprehensive information on experimental and analytic methods for each data set. A Data Intersection tool allows selection of a list of genes (proteins in common between two or more data sets and outputs the data for those genes (proteins in the respective sets. In addition to its role as an integrative resource for the NCI-60, the CellMiner package also serves as a shell for incorporation of molecular profile data on other cell or tissue sample types. Conclusion CellMiner is a relational database tool for

  3. Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging

    Husvogt, Lennart; Vardeh, Hilde; Faulkner-Jones, Beverly E.; Hornegger, Joachim; Connolly, James L.; Fujimoto, James G.

    2016-01-01

    We derive a physically realistic model for the generation of virtual transillumination, white light microscopy images using epi-fluorescence measurements from thick, unsectioned tissue. We demonstrate this technique by generating virtual transillumination H&E images of unsectioned human breast tissue from epi-fluorescence multiphoton microscopy data. The virtual transillumination algorithm is shown to enable improved contrast and color accuracy compared with previous color mapping methods. Finally, we present an open source implementation of the algorithm in OpenGL, enabling real-time GPU-based generation of virtual transillumination microscopy images using conventional fluorescence microscopy systems. PMID:27500636

  4. First steps into EPiServer CMS 7, Case: Seepia Games

    Mäkelä, Antti

    2015-01-01

    The main goal of this thesis was to collect and reflect on experiences from learning process while working with EPiServer CMS 7 content management system. This was done by going through phases of a case project. The project was done for a company called Seepia Games, whose activity is focused on mobile games. EPiServer is a company whose activity is focused on the Nordic countries. They provide content management and e-commerce software. The focus of their content management system is to ...

  5. The impact of susceptibility gradients on cartesian and spiral EPI for BOLD fMRI

    Sangill, Ryan; Wallentin, Mikkel; Østergaard, Leif;

    2006-01-01

    High sensitivity to magnetic susceptibility changes and accurate localization of functional activations are key requisites for pulse sequences used for BOLD fMRI. This paper seeks to develop a framework for analysing the performance of various k-space sampling techniques in this respect, with......, where EPI activation is offset from the true position. In the primary motor area spirals provide significantly higher t scores (P < 0.0002). In-plane variation of EPI is higher in phase-encoding direction than in frequency-encoding direction (P < 0.003). In the low SFG areas spirals provide stronger...

  6. Comparisons between the 2012 new CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equations and other four approved equations.

    Ying Zhu

    Full Text Available OBJECTIVE: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI reported two equations in 2012: one based on cystatin C concentration (CKD-EPI2012cys and the other using both serum creatinine and cystatin C concentrations (CKD-EPI2012Scr-cys. We compared the adaptability of new formulae with other four equations. METHODS: Participants (n = 788; median age, 54 [range, 19-94] years were recruited from the First Affiliated Hospital of Nanjing Medical University. The reference glomerular filtration rate (rGFR was measured by a (99mTc-DTPA renal dynamic imaging method, and the estimated glomerular filtration rate (eGFR was calculated separately by the Chinese adapted Modification of Diet in Renal Disease equation (C-MDRD, MacIsaac, Ma, serum creatinine-based CKD-EPI equation (CKD-EPI2009Scr, CKD-EPI2012cys and CKD-EPI2012Scr-cys equations. We compared the performance of six equations with rGFR. RESULTS: Median rGFR was 76.35 (interquartile range, 59.03-92.50 mL/min/1.73 m(2. Compared with CKD-EPI2009Scr, CKD-EPI2012Scr-cys formula had better diagnostic value with larger area under the receiver operating characteristic curve (ROC(AUC, 0.879, p = 0.006, especially in young participants (ROC(AUC, 0.883, p = 0.005. CKD-EPI2012cys equation did not perform better than other available equations. Accuracy (the proportion of eGFR within 30% of rGFR [P30] of the CKD-EPI2012Scr-cys equation (77.03% was inferior only to MacIsaac equation (80.2% in the entire participants, but performed best in young participants with normal or mildly-injured GFR. Neither of the two new CKD-EPI equations achieved any ideal P30 in the elderly participants with moderately-severely injured GFR. Linear regression analysis demonstrated a consistent result. In this study, CKD-EPI2012Scr-cys had a relatively better diagnosis consistency of GFR stage between the eGFR and rGFR in the whole cohort. CONCLUSION: CKD-EPI2012Scr-cys appeared less biased and more accurate

  7. PREFACE: PAGES 1st Young Scientists Meeting (YSM) - 'Retrospective views on our planet's future'

    Margrethe Basse, Ellen

    2010-03-01

    more recent pollution. The concept and format of the 1st PAGES YSM worked very well, and created a high degree of enthusiasm and stimulation among the participants (as is demonstrated by this special issue). The 2nd YSM is therefore firmly planned to take place in 2013, back-to-back with the 4th PAGES OSM. Crucial and gratefully acknowledged contributions to the success of the YSM were made by the numerous co-sponsors (see logos below), who provided the financial basis for the YSM and supported the attendance of many early-career researchers from various parts of the world. Furthermore, we cordially thank all reviewers for shaping this proceeding issue with their insightful and helpful reviews. Conference photograph

  8. When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?

    Soysal, Pinar; Aydin, Ali Ekrem; Koc Okudur, Saadet; Isik, Ahmet Turan

    2016-01-01

    Detection of orthostatic hypotension (OH) is very important in geriatric practice, since OH is associated with mortality, ischemic stroke, falls, cognitive failure and depression. It was aimed to determine the most appropriate time for measuring blood pressure in transition from supine to upright position in order to diagnose OH in elderly. Comprehensive geriatric assessment (CGA) including Head up Tilt Table (HUT) test was performed in 407 geriatric patients. Orthostatic changes were assessed separately for the 1st, 3rd and 5th minutes (HUT1, HUT3 and HUT5, respectively) taking the data in supine position as the basis. The mean age, recurrent falls, presence of dementia and Parkinson's disease, number of drugs, alpha-blocker and anti-dementia drug use, and fasting blood glucose levels were significantly higher in the patients with versus without OH; whereas, albumin and 25-hydroxy vitamin D levels were significantly lower (p<0.05). However, different from HUT3 and HUT5, Charlson Comorbidity Index and the prevalence of diabetes mellitus were higher, the use of antidiabetics, antipsychotics, benzodiazepine, opioid and levodopa were more common (p<0.05). Statistical significance of the number of drugs and fasting blood glucose level was prominent in HUT1 as compared to HUT3 (p<0.01, p<0.05). Comparison of the patients that had OH only in HUT1, HUT3or HUT5 revealed no difference in terms of CGA parameters. These results suggests that orthostatic blood pressure changes determined at the 1st minute might be more important for geriatric practice. Moreover, 1st minute measurement might be more convenient in the elderly as it requires shorter time in practice. PMID:27077324

  9. Educational impact of a clinical anatomy workshop on 1st-year orthopedic and rheumatology fellows in Mexico City.

    Saavedra, M A; Villaseñor-Ovies, P; Harfush, L A; Navarro-Zarza, J E; Canoso, J J; Cruz-Domínguez, P; Vargas, A; Hernández-Díaz, C; Chiapas-Gasca, K; Camacho-Galindo, J; Alvarez-Nemegyei, J; Kalish, R A

    2016-05-01

    We aim to study the educational impact of a clinical anatomy workshop in 1st-year orthopedic and rheumatology fellows. First-year rheumatology fellows (N = 17) and a convenience sample of 1st-year orthopedic fellows (N = 14) from Mexico City in the 9th month of training participated in the study. The pre- and the post- workshop tests included the same 20 questions that had to be answered by identification or demonstration of relevant anatomical items. The questions, arranged by anatomical regions, were asked in five dynamic stations. Overall, the 31 participants showed an increase of correct answers, from a median of 6 (range 1 to 12) in the pre-workshop test, to a median of 14 (range 7 to 19) in the post-workshop test. In the pre-workshop test, the correct median answers were 7 (range 2 to 12) in the orthopedic fellows and 5 (range 1 to 10) in the rheumatology fellows (p = 0.297). Corresponding scores in the post-workshop were 15 (range 10 to 19) and 12 (range 7 to 18) (p = 0.026) showing a significant difference favoring the orthopedic group. Our clinical anatomy workshop was efficacious, in the short term, as a teaching instrument for 1st-year orthopedic and rheumatology fellows. The post-workshop scores, although significantly improved in both groups, particularly in the orthopedic fellows, were still suboptimal. Further refinements of our workshop might yield better results. PMID:26400643

  10. Treatment of the carcinoma of the vulva at the 1st University-Clinic of Gynaecology in Vienna (386 cases)

    Kucera, H. (Vienna Univ. (Austria). Strahlenabteilung)

    1980-09-01

    In the department of radiotherapy of the 1st University-Clinic of Gynaecology and Obstetrics in Vienna the electroresection and electrocoagulation is practiced with good success in the treatment of carcinoma of the vulva. Of 386 treated cases with vulvar carcinoma, 234 (60,6%) were alive after five years. After surgical treatment the inguinal lymphonodes were irradiated (6000 rad). In comparison with the international statistic of the Annual Report of the results of treatment in gynaecological cancer (1979) the results obtained in Vienna are much better than the international average.

  11. Treatment of the carcinoma of the vulva at the 1st University-Clinic of Gynaecology in Vienna (386 cases)

    In the department of radiotherapy of the 1st University-Clinic of Gynaecology and Obstetrics in Vienna the electroresection and electrocoagulation is practiced with good success in the treatment of carcinoma of the vulva. Of 386 treated cases with vulvar carcinoma, 234 (60,6%) were alive after five years. After surgical treatment the inguinal lymphonodes were irradiated (6000 rad). In comparison with the international statistic of the Annual Report of the results of treatment in gynaecological cancer (1979) the results obtained in Vienna are much better than the international average. (orig.)

  12. Proceedings of the 1st Ibero-Latin American and Caribbean Congress on Medical Physics. Mexico 98

    This book composes the works received for the 1st Ibero-Latin American and the Caribbean Congress on Medical Physics. There are 68 works which represent a sample of the recent advances of the medical physics which are indicators about the level of development of the speciality in these regions of the world. Thus, the Congress represents the greatest event of medical physics of Ibero-Latin America and the Caribbean besides its consolidation and regional organization. The book also contains useful counsels for the education, yours researches and the daily hospitable practice. (Author)

  13. The evaluation of residual resource of the technological channels of the 1-st ChNPP's unit

    The result of study of the technological channels (TC) of the 1-st Chernobyl NPP's unit after 18 years of operation are analyzed in this work. It is showed that zirconium alloy of TC operated at normal conditions has satisfactory plastic and strength properties; hydrogen concentration doesn't exceed 60 ppm; the joint devices have safety factor more 2 even at presence of microcracks. The conclusion is done that residual resource of normal operating TC after 18 years of service doesn't still exhaust

  14. Palaeopathology of human remains of the 1st century BC–3rd century AD from Armenia (Beniamin, Shirakavan I)

    Khudaverdyan Anahit Yu.

    2015-01-01

    The aim of this article was to document the pathology of the individuals from the archeological sites of Beniamin and Shirakavan I, Armenia, dated on the 1st century BC - 3rd century AD. The findings revealed that two groups differed in mean age at death of adults. At Beniamin it was 24 years, 40.8 years for males and 30.9 years for females, whereas at Shirakavanit it was 29.3 years, 29.6 years for males and 35.8 years for females. The greatest mortality appeared to have occurred when the chi...

  15. PECULIAR FEATURES CONCERNING 1-ST-YEAR STUDENT ADAPTATION TO LIFE-ACTIVITY AT ENGINEERING HIGHER EDUCATIONAL INSTITUTION

    V. A. Klimenko

    2015-01-01

    Full Text Available The paper contains an analysis of peculiar features concerning a 1-st-year student adaptation to new conditions of life-activity  on the basis of self-evaluation made by 212 persons.  In order to obtain the data a methodology for diagnostics of social and psychological adaptation developed by K.Rodgers and R.Diamond has been applied with the purpose to study such integral indices as adaptivity, emotional comfort, friendly attitude, internality, tolerance and domination symptom.

  16. Innovation and Inclusion for a Prosperous Asia: Highlights of the 1st ADB-Asian Think Tank Development Forum

    Asian Development Bank (ADB)

    2014-01-01

    Innovation and Inclusion for a Prosperous Asia was the theme of the 1st ADB–Asian Think Tank Development Forum held on 30–31 October 2013 at the Tangla Hotel in Beijing. The forum was organized by ADB in partnership with the Asia–Pacific Finance and Development Center Beijing Office, a think tank of the People’s Republic of China’s Ministry of Finance. This publication documents the discussions on the latest global and regional policy developments and country-specific experiences and policy i...

  17. PYRAMIDS AND POPPIES; The 1st SA Infantry Brigade in Libya, France and Flanders 1915-1919

    Noëlle Cowling

    2012-01-01

    Pyramids and Poppies by Peter Digby is a book entirely devoted to the fortunes, and misfortunes, of the 1st South African Brigade during World War One. The Brigade was the first South African force ever to experience combat in Europe or North Africa. As this grants the contingent a distinctive standing in local military history, Pyramids and Poppies is a book which will be of interest, not only to World War One enthusiasts, but to most of warfare's other ardent fans as well.

  18. Evaluation of the children on trial in the Ankara 1st children s High Criminal Court for peer abuse

    ŞENGÜL, Hasan Atakan; CANTÜRK, Nergis; Cantürk, Gürol; Dağalp, Rukiye

    2012-01-01

    Aim: Children performing acts defined as criminal law are the children who are dragged into crime When the victim of the identified actions are children both the number of children who need protection and who are dragged into crime increases and the victim of both sides in the incident become children Material and Method: The case files and cartons of decisions of 188 events sentenced in the Ankara 1st Children rsquo;s High Criminal Court for 4 year period between 2007 2010 in which victims a...

  19. Development of Foreign Relations of Mongolia in the 1st half of the 20th century : Mongolia's struggle for independence

    Buyanlham Tumurjav; ブヤンルハム トムルジャブ

    2007-01-01

    This thesis is a historical analysis of the development of Foreign Relations of the Mongolian People’s Republic (Mongolia) in the 1st half of the 20th century. The main focus of the research is the struggle of this small nation, sandwiched between two giant neighbors, for its independence, which had been at stake several times in early 20th century. Prior to discussing independence movements in Mongolia, the research analyzed how Mongolia became a subject of another state, the Qing dynasty an...

  20. Lectures given at the 1st Session of the Centro Internazionale Matematico Estivo (C.I.M.E.)

    1990-01-01

    The courses given at the 1st C.I.M.E. Summer School of 1988 dealt with the main areas on the borderline between applied logic and theoretical computer science. These courses are recorded here in five expository papers: S. Homer: The Isomorphism Conjecture and its Generalization.- A. Nerode: Some Lectures on Intuitionistic Logic.- R.A. Platek: Making Computers Safe for the World. An Introduction to Proofs of Programs. Part I. - G.E. Sacks: Prolog Programming.- A. Scedrov: A Guide to Polymorphic Types.

  1. Global microRNA analysis of the NCI-60 cancer cell panel

    Søkilde, Rolf; Kaczkowski, Bogumil; Podolska, Agnieszka;

    2011-01-01

    progression of cancer, they comprise a novel class of promising diagnostic and prognostic molecular markers and potential drug targets. By applying an LNA-enhanced microarray platform, we studied the expression profiles of 955 miRNAs in the NCI-60 cancer cell lines and identified tissue- and cell...... contributes expression data for 369 miRNAs that have not previously been profiled. Finally, by matching drug sensitivity data for the NCI-60 cells to their miRNA expression profiles, we found numerous drug-miRNAs pairs, for which the miRNA expression and drug sensitivity profiles were highly correlated and...... thus represent potential candidates for further investigation of drug resistance and sensitivity mechanisms....

  2. Sistema de geolocalització d'incidències a la ciutat

    Barea Pagán, Silvia

    2012-01-01

    El servei de geolocalització d'incidències té l'objectiu de facilitar la comunicació de les incidències de l'espai públic de la nostra ciutat a les administracions locals. El ciutadà, al veure un mobiliari urbà defectuós, un arbre trencat o paviment en mal estat, podrà reportar la incidència fàcilment a l'ajuntament per a la seva resolució. El servicio de geolocalización de incidencias tiene el objetivo de facilitar la comunicación de las incidencias del espacio público de nuestra ciudad a...

  3. Methods for Selection of Cancer Patients and Predicting Efficacy of Combination Therapy | NCI Technology Transfer Center | TTC

    The Lung Cancer Biomarkers Group of the National Cancer Institute (NCI) seeks parties interested in collaborative research to further co-develop methods for selecting cancer patients for combination therapy.

  4. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2016

    NONE

    2016-06-06

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  5. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2015

    NONE

    2015-07-07

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2015. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  6. Assessment of C3-Epi-25-Hydroxyvitamin D concentration in adult serum: LC-MS/MS determination using [2H3] 3-epi-25OHD3 internal standard and NIST traceable commercial 3-epi-25OHD calibrators.

    Tang, Jonathan; Washbourne, Christopher; Budnik-Zawilska, Milka; Piec, Isabelle; Fraser, William

    2014-01-01

    Background: The C-3 Epimer of 25 Hydroxyvitamin D3 (3-Epi-25OHD3) is produced in the liver by the epimerisation pathway of 25-hydroxy vitamin D3. It differs from 25OHD3 in configuration of the hydroxyl group at the third carbon (C-3) position. Despite the fact that little is known regarding its clinical significance, concerns have been raised that isobaric interference may result in over-estimation of total 25OHD when measured by liquid chromatography tandem mass spectrometry (LC-MS/MS). Obje...

  7. Stress, Depression, Social Support, and Eating Habits Reduce Dietary Quality in the 1st Trimester in Low-Income Women: A Pilot Study

    Fowles, Eileen R.; Stang, Jamie; Bryant, Miranda; Kim, Sunghun

    2012-01-01

    Maternal diet quality influences birth outcomes. Yet little research exists that assesses women’s diet quality during the 1st trimester of pregnancy, a crucial time of placental and fetal development. This cross-sectional study describes diet quality and its relationship with stress, depression, social support, and eating habits in the 1st trimester that may identify low-income women needing intensive dietary intervention. Seventy-one low-income women completed validated instruments measuring...

  8. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

  9. On the numbers $e^e, e^{e^2}$ and $e^{\\pi^2}$.

    Waldschmidt, Michel

    1998-01-01

    International audience We give two measures of simultaneous approximation by algebraic numbers, the first one for the triple $( e, e^e, e^{e^2})$ and the second one for $(\\pi, e, e^{\\pi^2})$. We deduce from these measures two transcendence results which had been proved in the early 70's by W. D. Brownawell and the author.

  10. [EpiInfo as a research and teaching tool in epidemiology and statistics: strengths and weaknesses].

    Mannocci, Alice; Bontempi, Claudio; Giraldi, Guglielmo; Chiaradia, Giacomina; de Waure, Chiara; Sferrazza, Antonella; Ricciardi, Walter; Boccia, Antonio; La Torre, Giuseppe

    2012-01-01

    EpiInfo is a free software developed in 1988 by the Centers for Disease Control and Prevention (CDC) in Atlanta to facilitate field epidemiological investigations and statistical analysis. The aim of this study was to assess whether the software represents, in the Italian biomedical field, an effective analytical research tool and a practical and simple epidemiology and biostatistics teaching tool. A questionnaire consisting of 20 multiple-choice and open questions was administered to 300 healthcare workers, including doctors, biologists, nurses, medical students and interns, at the end of a CME course in epidemiology and biostatistics. Sixty-four percent of participants were aged between 26 and 45 years, 52% were women and 73% were unmarried. Results show that women are more likely to utilize EpiInfo in their research activities with respect to men (p = 0.023), as are individuals aged 26-45 years with respect to the older and younger age groups (p = 0.023) and unmarried participants with respect to those married (p = 0.010). Thirty-one percent of respondents consider EpiInfo to be more than adequate for analysis of their research data and 52% consider it to be sufficiently so. The inclusion of an EpiInfo course in statistics and epidemiology modules facilitates the understanding of theoretical concepts and allows researchers to more easily perform some of the clinical/epidemiological research activities. PMID:22507994

  11. SEB occurrence in a VIP: Influence of the epi-substrate junction

    Heavy ion induced burnout is reported, for the first time, in different parts of a VIP. A 2D-simulation investigation allows a better understanding of this phenomenon and shows the importance of the epi-substrate junction parameters in the SEB occurrence

  12. Life Cycle Assessment of waste management systems in Italian industrial areas: Case study of 1st Macrolotto of Prato

    Life Cycle Assessment (LCA) is not widely used as a decision-supporting tool in Italy, despite recent European Commission policies fostering its adoption to achieve an energy- and resource-efficient economy. In this paper, an LCA of waste management system of the 1st Macrolotto industrial area is presented. The aims of the study were to identify the environmental critical points of the system and to evaluate opportunities and problems in applying this methodology at industrial area level. After a description of the waste management system of the 1st Macrolotto industrial area, the main assumptions of the study and some elements of the system modelling are presented. Results confirmed that door-to-door separated collection and packaging recycling are successful strategies for reducing the use of natural resources. The cooperation of the waste management company, which was part of the area management structure, was strategic for the completion of the analysis. Country-specific databases and models should be developed for a widespread application of the LCA methodology to waste management in Italian industrial areas.

  13. A method of neptunium recovery into the product stream of the Purex 1st codecontamination step for LWR fuel reprocessing

    An improved nitrous acid method was applied for recovering neptunium in spent fuel. Counter-current solvent extraction has been performed to find out its recovery conditions. The nitrous acid in the form of sodium salt solution was fed to the 1st stage of extraction section, and hydrazine nitrate was fed to some stages near feed point. Flow rate and the concentration of additives were altered for finding out optimum condition. Laboratory scale mixer-settlers having 6 ml of mixing volume and 17 ml of settling volume for each stage were used. The nitrous acid method was improved so that the reduction reaction in scrub section can be eliminated by the decomposition of the nitrous acid using a reagent such as sulfamic acid, urea, or hydrazine. In operation, the feed rate of the nitrous acid was about 3 mM/hr, and about 61% of neptunium charged was discharged in the product stream of Purex-1st codecontamination step designed for the LWR fuel reprocessing plant of Power Reactor and Nuclear Fuel Development Corporation. The calculated value of Δx/x for extraction section agreed with the experimental value, where Δx is the quantity of oxidation, and x is the inventory for neptunium in each stage. In conclusion, the improved nitrous acid method is effective for the neptunium discharge in product stream, and the difference of neptunium extraction between estimate and experiment is caused by some of reduction reaction in scrub section. (Iwakiri, K.)

  14. BMI differences in 1st and 2nd generation immigrants of Asian and European origin to Australia.

    Hauck, Katharina; Hollingsworth, Bruce; Morgan, Lawrie

    2011-01-01

    We estimate assimilation of immigrants' body mass index (BMI) to the host population of Australia over one generation, conducting separate analyses for immigrants from 7 regions of Europe and Asia. We use quantile regressions to allow for differing impact of generational status across 19 quantiles of BMI from under-weight to morbidly obese individuals. We find that 1st generation South European immigrants have higher, and South and East Asian immigrants have lower BMI than Australians, but have assimilated to the BMI of their hosts in the 2nd generation. There are no or only small BMI differences between Australians and 1st and 2nd generation immigrants from East Europe, North-West Europe, Middle East and Pacific regions. We conclude that both upward and downward assimilation in some immigrant groups is most likely caused by factors which can change over one generation (such as acculturation), and not factors which would take longer to change (such as genetics). Our results suggest that public health policies targeting the lifestyles of well educated Asian immigrants may be effective in preventing BMI increase in this subgroup. PMID:20869292

  15. Epi-LASIK e PRK: um ano de estudo comparativo em olhos contralaterais

    Francisco Penteado Crestana

    2013-08-01

    Full Text Available OBJETIVO: Comparar as técnicas de PRK e Epi-LASIK com relação à recuperação visual e sintomatologia pós-operatória. MÉTODOS: Série de casos intervencionista que incluiu 38 olhos de 19 pacientes com miopia até 5DE e astigmatismo até 1DC. Foram selecionados pacientes com erros refracionais semelhantes nos dois olhos, realizando-se, no mesmo tempo cirúrgico, PRK em um olho e Epi-LASIK no olho contralateral. Os pacientes foram acompanhados por um ano, avaliando-se a eficácia refracional e grau de desconforto pós-operatório. RESULTADOS: Durante as primeiras 12 horas, 79,9% dos pacientes (p=0,0003 referiram dor mais intensa no olho operado com a técnica Epi-LASIK. Após 24 horas, 63,2% dos pacientes (p=0,012 ainda referiam mais dor neste olho e apenas 10,5% no olho contralateral. A acuidade visual não corrigida foi melhor nos olhos do grupo PRK no primeiro dia (p=0,034. Nos demais dias não houve diferença significativa entre os grupos. Houveopacidade corneana grau 0,5 (Fantes em três olhos do grupo PRK e em dois no grupo Epi-LASIK. CONCLUSÃO: Ambos os grupos apresentaram resultado visual refracional satisfatório, porém o grupo Epi-LASIK apresentou maior desconforto no pós-operatório imediato.

  16. Uso da sequência FLAIR-EPI na análise da esclerose mesial temporal EPI-FLAIR sequence in the evaluation of mesial temporal sclerosis

    Marcos Alberto da Costa Machado Júnior

    2001-06-01

    Full Text Available O objetivo deste estudo é analisar as alterações morfológicas e de intensidade de sinal das regiões hipocampais em pacientes, com epilepsia temporal fármaco-resistente. Para tal, estudamos 8 pacientes com esclerose mesial temporal, utilizando aparelhagem de RM de 1,5T, com sequências Spin Eco - SE, Fast Spin Eco - FSE, Fluid Atenuation Inversion Recovery, com Eco Planar Imaging - FLAIR-EPI. Observamos a superioridade da sequência FLAIR na detecção do aumento da intensidade de sinal da região hipocampal, particularmente com cortes coronais, em relação às sequências SE e FSE, com a vantagem de ser uma técnica de rápida execução. A sequência STIR evidenciou adelgaçamento da cortical do hipocampo, na metade dos casos que apresentavam alteração de sinal.The purpose of this study is to evaluate morpholologycal and signal intensity changes in the hippocampus in patients with medically intractable temporal lobe epilepsy. We studied 8 patients with mesial temporal sclerosis using a 1.5 -T MR and the following sequences Spin Eco- SE, Fast Spin Echo- FSE, Fluid Atenuation Inversion Recovery Echo Planar Imaging - FLAIR-EPI. We noticed a sensitive increase signal intensity on FLAIR- EPI sequences, particularly, in coronal images, than on SE and FSE sequences. The STIR sequence showed a cortical hippocampus atrophy in half of the cases, in whom signal abnormalities were present.

  17. Intemational collaborative study on the preparation of 1st international standard for rhTSH for bioassay

    The history of the international collaborative studies on the preparation of standards of TSH for bioassay and immunoassay was reviewed. The result of collaborative study on the 1st international standard for thyroid-stimulating hormone, recombinant, human, for bioassay was reported in detail in this article. Based on the results of this collaborative study, it is proposed that the candidate standard be established as the international standard for rhTSH for bioassay, and be assigned an activity of 9.5 IU per ampoule. The national standard preparation of TSH for immunoassay was also reassayed, revealing the potency to be 0.557 mIU/ampoule, i.e. 92. 8% of the labelled value of 0.600mIU/ampoule, a reasonable consistency. (authors)

  18. Proceedings of the 1st International Operational Modal Analysis Conference, April 26-27, 2005, Copenhagen, Denmark

    These proceedings contain approximately 100 papers presented at the 1st International Operational Modal Conference, Copenhagen, Denmark, April 26 - 27, 2005. The conference is jointly organised by Structural Vibration Systems (SVS), Aalborg, Brüel & Kjær Sound and Vibration Measurement A/S and the...... effort and higher versatility. However, because the mathematical background was initially weak, computer power was insufficient and the equipment not sensitive enough for this kind of testing, the technology has only become popular during the last 3 - 4 years. For this reason, the first conference on...... this subject is arranged with the intention of opening a broad scientific and technical forum for the further development of the technology. The main themes will cover theory and background as well as mechanical and civil engineering applications. We have encouraged a large number of people to...

  19. Report about the 1st De Frutos - Universidad Miguel Hernández Judo Scientific Congress with Training Camp

    Juan José Pulido González

    2013-12-01

    Full Text Available The current report resumes the 1st De Frutos-Universidad Miguel Hernández Judo Scientific Congress, held in San Juan de Alicante (Spain from the 27th to the 30th of June in 2013. Three plenary sessions in classroom, 12 oral communications, a round – table, 2 theoretical – practical workshops on tatami, and 3 randori sessions were developed. This congress was a new event where judo personalities at the international level as well as scientists from the whole Spanish geography interested in this field assisted. The event complied the aim to approach the science to judo professionals and vice versa. A total amount of 112 participants were in the congress.

  20. Evaluation of a modified team based learning method for teaching general embryology to 1 st year medical graduate students

    Shankar Nachiket

    2009-01-01

    Full Text Available Background and Aims: To encourage student participation in the learning process, the authors introduced a modified team based learning (TBL method to cover two general embryology topics in the 1 st year MBBS curriculum. The aim of this study was to evaluate students′ perception of this method vis-à-vis the lecture method of teaching. Settings and Design: A questionnaire was used to survey and evaluate the perceptions of 1 st year MBBS students at the Department of Anatomy at our medical college in India. Materials and Methods: A total of eight classes were allotted to cover General Embryology. Six of these classes were conducted using the traditional didactic lecture method. Two topics were covered using the modified TBL method. Five teams of students were constituted, and each team was given handouts which contained basic factual material, four clinical case histories, and previous university exam questions from the topic. On the day of the session, these were discussed in the presence of the faculty facilitator. Students evaluated these sessions through a questionnaire. Results: A majority of students felt that the modified TBL sessions were better at fulfilling learning objectives (46 students, 85%, enabled better understanding (43 students, 79%, were more interesting (43 students, 81%, ensured greater student participation (51 students, 94% and involved greater effort on the part of students (53 students, 98%, as compared to traditional teaching methods. Most of the students (43 students, 79% opined that more such sessions should be organized in the future. Conclusions: Responses from students show that the modified TBL classes could be utilized judiciously along with the traditional didactic lectures for teaching embryology.

  1. Modification of diet in renal disease (MDRD study and CKD epidemiology collaboration (CKD-EPI equations for Taiwanese adults.

    Ling-I Chen

    Full Text Available Estimated glomerular filtration rate (eGFR using the Modification of Diet in Renal Disease (MDRD study or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI equations may not be accurate for Asians; thus, we developed modified eGFR equations for Taiwanese adults.This cross-sectional study compared the Taiwanese eGFR equations, the MDRD study, and the CKD-EPI equations with inulin clearance (Cin. A total of 695 adults including 259 healthy volunteers and 436 CKD patients were recruited. Participants from the Kaohsiung Medical University Hospital were used as the development set (N = 556 to develop the Taiwanese eGFR equations, whereas participants from the National Taiwan University Hospital were used as the validation set (N = 139 for external validation.The Taiwanese eGFR equations were developed by using the extended Bland-Altman plot in the development set. The Taiwanese MDRD equation was 1.309 × MDRD0.912, Taiwanese CKD-EPI was 1.262×CKD-EPI0.914 and Taiwanese four-level CKD-EPI was 1.205 × four-level CKD-EPI0.914. In the validation set, the Taiwanese equations had the lowest bias, the Taiwanese equations and the Japanese CKD-EPI equation had the lowest RMSE, whereas the Taiwanese and the Japanese equations had the best precision and the highest P30 among all equations. However, the Taiwanese MDRD equation had higher concordance correlation than did the Taiwanese CKD-EPI, the Taiwanese four-level CKD-EPI and the Japanese equations. Moreover, only the Taiwanese equations had no proportional bias among all of the equations. Finally, the Taiwanese MDRD equation had the best diagnostic performance in terms of ordinal logistic regression among all of the equations.The Taiwanese MDRD equation is better than the MDRD, CKD-EPI, Japanese, Asian, Thai, Taiwanese CKD-EPI, and Taiwanese four-level CKD-EPI equations for Taiwanese adults.

  2. Social and moral norm differences among Portuguese 1st and 6th year medical students towards their intention to comply with hand hygiene.

    Roberto, Magda S; Mearns, Kathryn; Silva, Silvia A

    2012-01-01

    This study examines social and moral norms towards the intention to comply with hand hygiene among Portuguese medical students from 1st and 6th years (N = 175; 121 from the 1st year, 54 from the 6th year). The study extended the theory of planned behaviour theoretical principles and hypothesised that both subjective and moral norms will be the best predictors of 1st and 6th year medical students' intention to comply with hand hygiene; however, these predictors ability to explain intention variance will change according to medical students' school year. Results indicated that the subjective norm, whose referent focuses on professors, is a relevant predictor of 1st year medical students' intention, while the subjective norm that emphasises the relevance of colleagues predicts the intentions of medical students from the 6th year. In terms of the moral norm, 6th year students' intention is better predicted by a norm that interferes with compliance; whereas intentions from 1st year students are better predicted by a norm that favours compliance. Implications of the findings highlight the importance of role models and mentors as key factors in teaching hand hygiene in medical undergraduate curricula. PMID:22111788

  3. Acoustic stratigraphy and hydrothermal activity within Epi Submarine Caldera, Vanuatu, New Hebrides Arc

    Greene, H. Gary; Exon, N.F.

    1988-01-01

    Geological and geophysical surveys of active submarine volcanoes offshore and southeast of Epi Island, Vanuatu, New Hebrides Arc, have delineated details of the structure and acoustic stratigraphy of three volcanic cones. These submarine cones, named Epia, Epib, and Epic, are aligned east-west and spaced 3.5 km apart on the rim of a submerged caldera. At least three acoustic sequences, of presumed Quaternary age, can be identified on single-channel seismic-reflection profiles. Rocks dredged from these cones include basalt, dacite, and cognate gabbroic inclusions with magmatic affinities similar to those of the Karua (an active submarine volcano off the southeastern tip of Epi) lavas. ?? 1988 Springer-Verlag New York Inc.

  4. EpiTools: An Open-Source Image Analysis Toolkit for Quantifying Epithelial Growth Dynamics

    Heller, Davide; Hoppe, Andreas; Restrepo, Simon; Gatti, Lorenzo; Tournier, Alexander L.; Tapon, Nicolas; Basler, Konrad; Mao, Yanlan

    2016-01-01

    Summary Epithelia grow and undergo extensive rearrangements to achieve their final size and shape. Imaging the dynamics of tissue growth and morphogenesis is now possible with advances in time-lapse microscopy, but a true understanding of their complexities is limited by automated image analysis tools to extract quantitative data. To overcome such limitations, we have designed a new open-source image analysis toolkit called EpiTools. It provides user-friendly graphical user interfaces for accurately segmenting and tracking the contours of cell membrane signals obtained from 4D confocal imaging. It is designed for a broad audience, especially biologists with no computer-science background. Quantitative data extraction is integrated into a larger bioimaging platform, Icy, to increase the visibility and usability of our tools. We demonstrate the usefulness of EpiTools by analyzing Drosophila wing imaginal disc growth, revealing previously overlooked properties of this dynamic tissue, such as the patterns of cellular rearrangements. PMID:26766446

  5. The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: detailed protocol and harmonized scoring atlas.

    Dahl, Erica L; Curren, Rodger; Barnett, Brenda C; Khambatta, Zubin; Reisinger, Kerstin; Ouedraogo, Gladys; Faquet, Brigitte; Ginestet, Anne-Claire; Mun, Greg; Hewitt, Nicola J; Carr, Greg; Pfuhler, Stefan; Aardema, Marilyn J

    2011-02-28

    The European Cosmetic Toiletry and Perfumery Association (COLIPA), along with contributions from the European Centre for the Validation of Alternative Methods (ECVAM), initiated a multi-lab international prevalidation project on the reconstructed skin micronucleus (RSMN) assay in EpiDerm™ for the assessment of the genotoxicity of dermally applied chemicals. The first step of this project was to standardize the protocol and transfer it to laboratories that had not performed the assay before. Here we describe in detail the protocol for the RSMN assay in EpiDerm™ and the harmonized guidelines for scoring, with an atlas of cell images. We also describe factors that can influence the performance of the assay. Use of these methods will help new laboratories to conduct the assay, thereby further increasing the database for this promising new in vitro genotoxicity test. PMID:21147256

  6. Desenrotllament de les competències amb la creació de relats digitals

    Torre, Antoni de la

    2013-01-01

    La lectura prescrita a classe de llengua i literatura no s’aborda normalment com un projecte global que contemple les possibilitats de creativitat de l’alumne mitjançant la qual entren en joc diverses competències. El lector adolescent pot mostrar encara diverses reaccions positives que activen la comprensió del text literari. Tanmateix els seus professors no solen aprofitar-les per a multiplicar els aprenentatges que un llibre proposa en l’era digital. L’article parteix de la base que el gau...

  7. Microsoft Office 365 Deployment Continues through June at NCI at Frederick | Poster

    The latest Microsoft suite, Office 365 (O365), is being deployed to all NCI at Frederick computers during the months of May and June to comply with federal mandates. The suite includes the latest versions of Word, Excel, Outlook, PowerPoint, and Skype for Business, along with cloud-based capabilities. These cloud-based capabilities will help meet the federal mandates that require all Health and Human Services operating divisions to migrate e-mail to the cloud by the end of 2016.

  8. Anàlisi forense d'evidències digitals

    Bonachera López, Esteban

    2014-01-01

    L'objectiu principal d'aquest projecte consisteix en la realització de l'anàlisi forense del disc dur i de la memòria RAM d'un ordinador personal, en concret un Netbook, vinculat a una possible conducta delictiva. També s'inclou en l'anàlisi una base de dades del conegut programari WhatsApp extreta d'un smartphone. Per realitzar aquesta tasca s'utilitzaran eines específiques per localitzar les evidències digitals que puguin demostrar els presumptes delictes.

  9. Quantification of Biodegradation: Applied Example on Oil Seeps in Armàncies Fm, Southeastern Pyrenees

    Permanyer, Albert; Caja, Miguel Ángel

    2005-01-01

    La presencia de petróleo expulsado directamente de la roca madre de la Formación Armàncies, constituye un caso único para el estudio de los procesos de biodegradación aeróbica en petróleo. El estado de degradación bacteriana es moderado y está principalmente limitado a la alteración de n-alcanos, isoprenoides y algunos aromáticos. La cuantificación ha sido realizada mediante el contenido en sulfuro y con los marcadores moleculares de la fracción aromática. Los resultados obtenidos...

  10. Biosynthetic potential of sesquiterpene synthases: Alternative products of tobacco 5-epi-aristolochene synthase

    O’Maille, Paul E.; Chappell, Joe; Noel, Joseph P.

    2006-01-01

    Nicotiana tabacum (tobacco) 5-epi-aristolochene synthase (TEAS) serves as an useful model for understanding the enzyme mechanisms of sesquiterpene biosynthesis. Despite extensive bio-chemical and structural characterization of TEAS, a more detailed analysis of the reaction product spectrum is lacking. This study reports the discovery and quantification of several alternative sesquiterpene products generated by recombinant TEAS in the single-vial GC–MS assay. The combined use of chiral and non...

  11. Homeopathic medical practice for anxiety and depression in primary care: the EPI3 cohort study

    Grimaldi-Bensouda, Lamiae; Abenhaim, Lucien; Massol, Jacques; Guillemot, Didier; Avouac, Bernard; Duru, Gerard; Lert, France; Magnier, Anne-Marie; Rossignol, Michel; Rouillon, Frederic; Begaud, Bernard; ,

    2016-01-01

    Background The purpose of the study was to compare utilization of conventional psychotropic drugs among patients seeking care for anxiety and depression disorders (ADDs) from general practitioners (GPs) who strictly prescribe conventional medicines (GP-CM), regularly prescribe homeopathy in a mixed practice (GP-Mx), or are certified homeopathic GPs (GP-Ho). Methods This was one of three epidemiological cohort studies (EPI3) on general practice in France, which included GPs and their patients ...

  12. Evaluation of Multiband EPI Acquisitions for Resting State fMRI.

    Christine Preibisch

    Full Text Available Functional magnetic resonance imaging (fMRI and particularly resting state fMRI (rs-fMRI is widely used to investigate resting state brain networks (RSNs on the systems level. Echo planar imaging (EPI is the state-of-the-art imaging technique for most fMRI studies. Therefore, improvements of EPI might lead to increased sensitivity for a large amount of studies performed every day. A number of developments to shorten acquisition time have been recently proposed and the multiband technique, allowing the simultaneous acquisition of multiple slices yielding an equivalent reduction of measurement time, is the most promising among them. While the prospect to significantly reduce acquisition time by means of high multiband acceleration factors (M appears tempting, signal quality parameters and the sensitivity to detect common RSNs with increasing M-factor have only been partially investigated up to now. In this study, we therefore acquired rs-fMRI data from 20 healthy volunteers to systematically investigate signal characteristics and sensitivity for brain network activity in datasets with increasing M-factor, M = 2 - 4. Combined with an inplane, sensitivity encoding (SENSE, acceleration factor, S = 2, we applied a maximal acceleration factor of 8 (S2×M4. Our results suggest that an M-factor of 2 (total acceleration of 4 only causes negligible SNR decrease but reveals common RSN with increased sensitivity and stability. Further M-factor increase produced random artifacts as revealed by signal quality measures that may affect interpretation of RSNs under common scanning conditions. Given appropriate hardware, a mb-EPI sequence with a total acceleration of 4 significantly reduces overall scanning time and clearly increases sensitivity to detect common RSNs. Together, our results suggest mb-EPI at moderate acceleration factors as a novel standard for fMRI that might increase our understanding of network dynamics in healthy and diseased brains.

  13. EpiCollect+: linking smartphones to web applications for complex data collection projects

    Aanensen, David M.; Huntley, Derek M.; Mirko Menegazzo; Powell, Chris I.; Spratt, Brian G.

    2014-01-01

    Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry), whereas many applications require a more complex structure, allowing users to link a...

  14. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T

    Qiuting Wen

    2015-01-01

    Full Text Available Recent technological progress in the multiband echo planer imaging (MB EPI technique enables accelerated MR diffusion weighted imaging (DWI and allows whole brain, multi-b-value diffusion imaging to be acquired within a clinically feasible time. However, its applications at 7 T have been limited due to B1 field inhomogeneity and increased susceptibility artifact. It is an ongoing debate whether DWI at 7 T can be performed properly in patients, and a systematic SNR comparison for multiband spin-echo EPI between 3 T and 7 T has not been methodically studied. The goal of this study was to use MB EPI at 7 T in order to obtain 90-directional multi-shell DWI within a clinically feasible acquisition time for patients with glioma. This study included an SNR comparison between 3 T and 7 T, and the application of B1 mapping and distortion correction procedures for reducing the impact of variations in B0 and B1. The optimized multiband sequence was applied in 20 patients with glioma to generate both DTI and NODDI maps for comparison of values in tumor and normal appearing white matter (NAWM. Our SNR analysis showed that MB EPI at 7 T was comparable to that at 3 T, and the data quality acquired in patients was clinically acceptable. NODDI maps provided unique contrast within the T2 lesion that was not seen in anatomical images or DTI maps. Such contrast may reflect the complexity of tissue compositions associated with disease progression and treatment effects. The ability to consistently obtain high quality diffusion data at 7 T will contribute towards the implementation of a comprehensive brain MRI examination at ultra-high field.

  15. Designing the Expanded Programme on Immunisation (EPI) as a service: Prioritising patients over administrative logic

    McKnight, J.; Holt, D. B.

    2014-01-01

    Expanded Programme on Immunisation (EPI) vaccination rates remain well below herd immunity in regions of many countries despite huge international resources devoted to both financing and access. We draw upon service marketing theory, organisational sociology, development anthropology and cultural......-the-ground problems that mothers face in trying to vaccinate their children, while instead prioritising administrative processes. Our ethnographic analysis of 83 mothers who had not vaccinated their children reveals key barriers to vaccination from a 'customer' perspective. While mothers value vaccination...

  16. [2H26]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

    Christian A. Citron; Dickschat, Jeroen S.

    2013-01-01

    During growth on fully deuterated medium the volatile terpene [2H26]-1-epi-cubenol was released by the actinomycete Streptomyces griseus. This compound represents the first completely deuterated terpene obtained by fermentation. Despite a few previous reports in the literature the operability of this approach to fully deuterated compounds is still surprising, because the strong kinetic isotope effect of deuterium is known to slow down all metabolic processes in living organisms. Potential app...

  17. Q-EPI-Lasik在伴有老视的近视患者术中的应用研究%Research on clinical application of Q-EPI-Lasik in myopic patients associated with presbyopia

    杨智; 陈陟; 欧阳俊; 周晶蓉; 梁莉

    2012-01-01

    目的:评价Q值调整的EPI-Lasik(以下简称Q-EPI-Lasik)在老视患者行近视手术中的疗效.方法:对于100例伴有老视的近视患者行EPI-Lasik,将其目标Q值调整到-0.5~ -0.9,观察术后远近视力及视觉质量的恢复.结果:99例患者获得了满意的疗效,仅1例患者主诉远视力较差.结论:Q-EPI-Lasik应用在伴有老视的近视患者术中,能够使患者获得良好的远近视力及视觉质量.%Objective:To evaluate effectiveness of Q value adjusted EPI-Lasik (hereinafter referred to as Q-EPI-Lasik) in near-sight corrective operations for myopic patients associated with presbyopia. Methods; EPI-Lasik wasapplied to 100 myopic patients associated with presbyopia, the Q values was adjusted to -0.5~-0.9. Postoperative recovery of distant, intermediate vision and visual quality were observed. Results; 99 of the 100 patients with satisfactory effectiveness, only 1 patient complained of poor distant vision. Conclusion: application of Q-EPI-Lasik in corrective operations for myopic patients associated with presbyopia enables the patients to gain good distant, intermediate vision and good visual quality.

  18. Study of clutter origin in in-vivo epi-optoacoustic imaging of human forearms

    Preisser, Stefan; Held, Gerrit; Akarçay, Hidayet G.; Jaeger, Michael; Frenz, Martin

    2016-09-01

    Epi-optoacoustic (OA) imaging offers flexible clinical diagnostics of the human body when the irradiation optic is attached to or directly integrated into the acoustic probe. Epi-OA images, however, encounter clutter that deteriorates contrast and significantly limits imaging depth. This study elaborates clutter origin in clinical epi-optoacoustic imaging using a linear array probe for scanning the human forearm. We demonstrate that the clutter strength strongly varies with the imaging location but stays stable over time, indicating that clutter is caused by anatomical structures. OA transients which are generated by strong optical absorbers located at the irradiation spot were identified to be the main source of clutter. These transients obscure deep in-plane OA signals when detected by the transducer either directly or after being acoustically scattered in the imaging plane. In addition, OA transients generated in the skin below the probe result in acoustic reverberations, which cause problems in image interpretation and limit imaging depth. Understanding clutter origin allows a better interpretation of clinical OA imaging, helps to design clutter compensation techniques and raises the prospect of contrast optimization via the design of the irradiation geometry.

  19. DESIGN OF LOW EPI AND HIGH THROUGHPUT CORDIC CELL TO IMPROVE THE PERFORMANCE OF MOBILE ROBOT

    P. VELRAJKUMAR

    2014-04-01

    Full Text Available This paper mainly focuses on pass logic based design, which gives an low Energy Per Instruction (EPI and high throughput COrdinate Rotation Digital Computer (CORDIC cell for application of robotic exploration. The basic components of CORDIC cell namely register, multiplexer and proposed adder is designed using pass transistor logic (PTL design. The proposed adder is implemented in bit-parallel iterative CORDIC circuit whereas designed using DSCH2 VLSI CAD tool and their layouts are generated by Microwind 3 VLSI CAD tool. The propagation delay, area and power dissipation are calculated from the simulated results for proposed adder based CORDIC cell. The EPI, throughput and effect of temperature are calculated from generated layout. The output parameter of generated layout is analysed using BSIM4 advanced analyzer. The simulated result of the proposed adder based CORDIC circuit is compared with other adder based CORDIC circuits. From the analysis of these simulated results, it was found that the proposed adder based CORDIC circuit dissipates low power, gives faster response, low EPI and high throughput.

  20. Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

    Damir Jacob Illich

    2016-04-01

    Full Text Available It has previously been reported that mouse epiblast stem cell (EpiSC lines comprise heterogeneous cell populations that are functionally equivalent to cells of either early- or late-stage postimplantation development. So far, the establishment of the embryonic stem cell (ESC pluripotency gene regulatory network through the widely known chemical inhibition of MEK and GSK3beta has been impractical in late-stage EpiSCs. Here, we show that chemical inhibition of casein kinase 1alpha (CK1alpha induces the conversion of recalcitrant late-stage EpiSCs into ESC pluripotency. CK1alpha inhibition directly results in the simultaneous activation of the WNT signaling pathway, together with inhibition of the TGFbeta/SMAD2 signaling pathway, mediating the rewiring of the gene regulatory network in favor of an ESC-like state. Our findings uncover a molecular mechanism that links CK1alpha to ESC pluripotency through the direct modulation of WNT and TGFbeta signaling.

  1. Simultaneous Reduction of Two Common Autocalibration Errors in GRAPPA EPI Time Series Data

    Sheltraw, D; Deshpande, V; Trumpis, M

    2012-01-01

    The GRAPPA (GeneRalized Autocalibrating Partially Parallel Acquisitions) method of parallel MRI makes use of an autocalibration scan (ACS) to determine a set of synthesis coefficients to be used in the image reconstruction. For EPI time series the ACS data is usually acquired once prior to the time series. In this case the interleaved R-shot EPI trajectory, where R is the GRAPPA reduction factor, offers advantages which we justify from a theoretical and experimental perspective. Unfortunately, interleaved R-shot ACS can be corrupted due to perturbations to the signal (such as direct and indirect motion effects) occurring between the shots, and these perturbations may lead to artifacts in GRAPPA-reconstructed images. Consequently we also present a method of acquiring interleaved ACS data in a manner which can reduce the effects of inter-shot signal perturbations. This method makes use of the phase correction data, conveniently a part of many standard EPI sequences, to assess the signal perturbations between th...

  2. Alteration of 8-epi-prostaglandin F2α in plasma and RBC membrane during irradiation injury

    8-epi-prostaglandin F2α (8-epi-PGF2α) is formed by oxygen free radical-catalyzed lipid peroxidation and is independent of cyclooxygenase. The dogs were irradiated with 60Co-γ rays at a total dose of 3 Gy. During and after irradiation, the 8-epi-PGF2α concentrations of their plasma and RBC membrane were significantly increased and this reaction could be inhibited by superoxide dismutase. On the other hand, melondialdehyde level in either plasma or RBC membrane was not changed. These results suggest that 8-epi-PGF2α might serve as a new and sensitive marker of peroxidation reaction induced by radiation injury. (10 refs., 2 figs., 3 tabs.)

  3. Interleaved EPI based fMRI improved by multiplexed sensitivity encoding (MUSE) and simultaneous multi-band imaging.

    Chang, Hing-Chiu; Gaur, Pooja; Chou, Ying-hui; Chu, Mei-Lan; Chen, Nan-kuei

    2014-01-01

    Functional magnetic resonance imaging (fMRI) is a non-invasive and powerful imaging tool for detecting brain activities. The majority of fMRI studies are performed with single-shot echo-planar imaging (EPI) due to its high temporal resolution. Recent studies have demonstrated that, by increasing the spatial-resolution of fMRI, previously unidentified neuronal networks can be measured. However, it is challenging to improve the spatial resolution of conventional single-shot EPI based fMRI. Although multi-shot interleaved EPI is superior to single-shot EPI in terms of the improved spatial-resolution, reduced geometric distortions, and sharper point spread function (PSF), interleaved EPI based fMRI has two main limitations: 1) the imaging throughput is lower in interleaved EPI; 2) the magnitude and phase signal variations among EPI segments (due to physiological noise, subject motion, and B0 drift) are translated to significant in-plane aliasing artifact across the field of view (FOV). Here we report a method that integrates multiple approaches to address the technical limitations of interleaved EPI-based fMRI. Firstly, the multiplexed sensitivity-encoding (MUSE) post-processing algorithm is used to suppress in-plane aliasing artifacts resulting from time-domain signal instabilities during dynamic scans. Secondly, a simultaneous multi-band interleaved EPI pulse sequence, with a controlled aliasing scheme incorporated, is implemented to increase the imaging throughput. Thirdly, the MUSE algorithm is then generalized to accommodate fMRI data obtained with our multi-band interleaved EPI pulse sequence, suppressing both in-plane and through-plane aliasing artifacts. The blood-oxygenation-level-dependent (BOLD) signal detectability and the scan throughput can be significantly improved for interleaved EPI-based fMRI. Our human fMRI data obtained from 3 Tesla systems demonstrate the effectiveness of the developed methods. It is expected that future fMRI studies requiring high

  4. Interleaved EPI based fMRI improved by multiplexed sensitivity encoding (MUSE and simultaneous multi-band imaging.

    Hing-Chiu Chang

    Full Text Available Functional magnetic resonance imaging (fMRI is a non-invasive and powerful imaging tool for detecting brain activities. The majority of fMRI studies are performed with single-shot echo-planar imaging (EPI due to its high temporal resolution. Recent studies have demonstrated that, by increasing the spatial-resolution of fMRI, previously unidentified neuronal networks can be measured. However, it is challenging to improve the spatial resolution of conventional single-shot EPI based fMRI. Although multi-shot interleaved EPI is superior to single-shot EPI in terms of the improved spatial-resolution, reduced geometric distortions, and sharper point spread function (PSF, interleaved EPI based fMRI has two main limitations: 1 the imaging throughput is lower in interleaved EPI; 2 the magnitude and phase signal variations among EPI segments (due to physiological noise, subject motion, and B0 drift are translated to significant in-plane aliasing artifact across the field of view (FOV. Here we report a method that integrates multiple approaches to address the technical limitations of interleaved EPI-based fMRI. Firstly, the multiplexed sensitivity-encoding (MUSE post-processing algorithm is used to suppress in-plane aliasing artifacts resulting from time-domain signal instabilities during dynamic scans. Secondly, a simultaneous multi-band interleaved EPI pulse sequence, with a controlled aliasing scheme incorporated, is implemented to increase the imaging throughput. Thirdly, the MUSE algorithm is then generalized to accommodate fMRI data obtained with our multi-band interleaved EPI pulse sequence, suppressing both in-plane and through-plane aliasing artifacts. The blood-oxygenation-level-dependent (BOLD signal detectability and the scan throughput can be significantly improved for interleaved EPI-based fMRI. Our human fMRI data obtained from 3 Tesla systems demonstrate the effectiveness of the developed methods. It is expected that future fMRI studies

  5. Posterior Corneal Curvature Assessment after Epi-LASIK for Myopia: Comparison of Orbscan II and Pentacam Imaging

    Byun, Yong-Soo; Chung, So-Hyang; Park, Young-Geun; Joo, Choun-Ki

    2012-01-01

    Purpose To compare the changes in posterior corneal curvature using scanning slit topography (Orbscan II) and Scheimpflug imaging (Pentacam) before and after Epi-laser in situ keratomileusis (LASIK) for myopia. Methods In a prospective observational case-series study, 20 myopic patients having undergone Epi-LASIK were examined serially with two different devices, Orbscan II and Pentacam, preoperatively and one month postoperatively. Posterior central elevation (PCE) and posterior maximal elev...

  6. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

    Rivka Colen

    2014-10-01

    Full Text Available The National Cancer Institute (NCI Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems.” The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research.

  7. Receptor-Based Virtual Screening of EGFR Kinase Inhibitors from the NCI Diversity Database

    Kiattawee Choowongkomon

    2010-06-01

    Full Text Available Epidermal growth factor receptor (EGFR abnormalities have been associated with several types of human cancer. The crystal structures of its tyrosine kinase domain (EGFR-TK complexed with small molecule inhibitors revealed the kinase inhibition modes, prompting us to search for novel anti-cancer drugs. A total of 1,990 compounds from the National Cancer Institute (NCI diversity set with nonredundant structures have been tested to inhibit cancer cell lines with unknown mechanism. Cancer inhibition through EGFR-TK is one of the mechanisms of these compounds. In this work, we performed receptor-based virtual screening against the NCI diversity database. Using two different docking algorithms, AutoDock and Gold, combined with subsequent post-docking analyses, we found eight candidate compounds with high scoring functions that all bind to the ATP-competitive site of the kinase. None of these compounds belongs to the main group of the currently known EGFR-TK inhibitors. Binding mode analyses revealed that the way these compounds complexed with EGFR-TK differs from quinazoline inhibitor binding and the interaction mainly involves hydrophobic interactions. Also, the common kinase-inhibitor (NH---N and CO---HC hydrogen bonds between the hinge region and the hit compounds are rarely observed. Our results suggest that these molecules could be developed as novel lead compounds in anti-cancer drug design.

  8. The national cancer institute (NCI) and cancer biology in a 'post genome world'

    The National Cancer Institute (NCI) exists to reduce the burden of all cancers through research and discovery. Extensive restructuring of the NCI over the past year has been aimed at assuring that the institution functions in all ways to promote opportunities for discovery in the laboratory, in the clinic, and in the community. To do this well requires the difficult and almost paradoxical problem of planning for scientific discovery which, in turn is based on the freedom to pursue the unanticipated. The intellectual and structural landscape of science is changing and it places new challenges, new demands and new opportunities for facilitating discovery. The nature of cancer as a disease of genomic instability and of accumulated genetic change, coupled with a possibility of the development of new technologies for reading, utilizing, interpreting and manipulating the genome of single cells, provides unprecedented opportunities for a new type of high through-put biology that will change the nature of discovery, cancer detection, diagnosis, prognosis, therapeutic decision-making and therapeutic discovery. To capture these new opportunities will require attention to be paid to integrate the development of technology and new scientific discoveries with the ability to apply advances rapidly and efficiently through clinical trials

  9. Estudi de les diferències psicopatològiques en pacients amb mal de cap crònic, episòdic i control. Relació amb la resposta al tractament

    Sala Matavera, Isabel

    2010-01-01

    La cefalea o mal de cap és un dels motius de consulta més freqüents als serveis de neurologia i molt prevalent a la població general. Sovint, el maneig és difícil perquè a vegades poden coexistir més d’un tipus de cefalea, no es posa suficient atenció a la comorbilitat (psicopatologia) o a altres factors que poden empitjorar la progressió de la cefalea com per exemple l’abús farmacològic. Aquest treball té per objectius (1) comparar els perfils psicopatològics de pacients amb cefalea cr...

  10. Echo-planar magnetic resonance imaging (EPI) with high-resolution matrix in intra-axial brain tumors

    Bruening, R.; Scheidler, J.; Porn, U.; Reiser, M. [Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Seelos, K.; Yousry, T. [Department of Neuroradiology, Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Exner, H. [Institute for Medical Epidemiology, Klinikum Grosshadern, University of Munich, Munich (Germany); Rosen, B.R. [Department of Radiology, Massachusetts General Hospital, NMR Center, Charlestown, MA (United States)

    1999-09-01

    The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investigated on a 1.5-T scanner. The conventional scan (SE, TR/TE = 2200/80 ms, 18 slices) was acquired in 8 min, 4 s, and EPI (TR/TE = 3000/80 ms, 18 slices) was completed in 25 s. The films were compared in a blinded trail by three radiologists. On the general impression and anatomic display, both sequences were rated to be of similar quality. Artifacts were slightly more pronounced at the skull base and around surgical clips using EPI. Tumor delineation was nearly equivalent using EPI, compared with the T2-weighted sequence. Echo-planar imaging reached diagnostic quality in all patients. Interleaved high-resolution EPI yielded sufficient quality to depict intra-axial, supratentorial brain tumors. Since EPI can be obtained in a small fraction of the time needed for conventional spin echo, in addition to other indications it could be considered to study patients unable to cooperate. (orig.) With 3 figs., 3 tabs., 27 refs.

  11. Echo-planar magnetic resonance imaging (EPI) with high-resolution matrix in intra-axial brain tumors

    The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investigated on a 1.5-T scanner. The conventional scan (SE, TR/TE = 2200/80 ms, 18 slices) was acquired in 8 min, 4 s, and EPI (TR/TE = 3000/80 ms, 18 slices) was completed in 25 s. The films were compared in a blinded trail by three radiologists. On the general impression and anatomic display, both sequences were rated to be of similar quality. Artifacts were slightly more pronounced at the skull base and around surgical clips using EPI. Tumor delineation was nearly equivalent using EPI, compared with the T2-weighted sequence. Echo-planar imaging reached diagnostic quality in all patients. Interleaved high-resolution EPI yielded sufficient quality to depict intra-axial, supratentorial brain tumors. Since EPI can be obtained in a small fraction of the time needed for conventional spin echo, in addition to other indications it could be considered to study patients unable to cooperate. (orig.)

  12. Invasive pneumococcal disease in healthy adults: increase of empyema associated with the clonal-type Sweden(1-ST306.

    Imma Grau

    Full Text Available BACKGROUND: Adult invasive pneumococcal disease (IPD occurs mainly in the elderly and patients with co-morbidities. Little is known about the clinical characteristics, serotypes and genotypes causing IPD in healthy adults. METHODS: We studied 745 culture-proven cases of IPD in adult patients aged 18-64 years (1996-2010. Patients were included in two groups: 1. adults with co-morbidities, and 2. healthy adults, who had no prior or coincident diagnosis of a chronic or immunosuppressive underlying disease. Microbiological studies included pneumococcal serotyping and genotyping. RESULTS: Of 745 IPD episodes, 525 (70% occurred in patients with co-morbidities and 220 (30% in healthy adults. The healthy adults with IPD were often smokers (56% or alcohol abusers (18%. As compared to patients with co-morbidities, the healthy adults had (P<0.05: younger age (43.5+/-13.1 vs. 48.7+/-11.3 years; higher proportions of women (45% vs. 24%, pneumonia with empyema (15% vs. 7% and infection with non-PCV7 serotypes including serotypes 1 (25% vs. 5%, 7F (13% vs. 4%, and 5 (7% vs. 2%; and lower mortality (5% vs. 20%. Empyema was more frequently caused by serotype 1. No death occurred among 79 patients with serotype 1 IPD. There was an emergence of virulent clonal-types Sweden(1-ST306 and Netherlands(7F-ST191. The vaccine serotype coverage with the PCV13 was higher in healthy adults than in patients with co-morbidities: 82% and 56%, respectively, P<0.001. CONCLUSION: In this clinical study, one-third of adults with IPD had no underlying chronic or immunosuppressive diseases (healthy adults. They were often smokers and alcohol abusers, and frequently presents with pneumonia and empyema caused by virulent clones of non-PCV7 serotypes such as the Sweden(1-ST306. Thus, implementing tobacco and alcohol abuse-cessation measures and a proper pneumococcal vaccination, such as PCV13 policy, in active smokers and alcohol abusers may diminish the burden of IPD in adults.

  13. Matrine suppresses invasion and metastasis of NCI-H1299 cells by enhancing microRNA-133a expression

    Liao, Hehe; Zhao, Xixi; Qu, Jinkun; ZHANG, Jia; Cai, Hui

    2015-01-01

    Matrine has been proved to inhibit proliferation and induce apoptosis of human lung cancer cells. However, less studies involved in evaluating the effects and mechanism of matrine in cell migration and invasion of lung cancer. This study was aim to investigate the involvement of miR-133a in matrine’s anti-invasion and anti-metastasis in lung cancer. MTT assay was used to assess the inhibition of proliferation effects of matrine in NCI-H1299 cells. Migration and invasion abilities of NCI-H1299...

  14. Case Study of Severe Lightning Activity Prior to and During the Outbreak of the June 1st Greenbelt Tornado

    Barnum, B. H.; Badesha, S.; Shishineh, A.; Adams, N. H.

    2012-12-01

    Surges in lightning activity have been known to be associated with the outbreak of tornado activity. We present a case study of a tornado that touched down near Greenbelt Maryland during the evening of June 1st 2012. Preceding the tornado touchdown, two single point lightning detection systems, a Boltek LD-250 and Vaisala SA20, recorded very high lightning activity rates. An electric field mill (EFM) was also making measurements and recorded large, rapid amplitude oscillations in the vertical electric fields. These electric field oscillations quickly subsided after the initial tornado touchdown. The lightning activity also generated significant RF interference in the S-band dish antenna operated at the Applied Physics Laboratory. It was somewhat surprising that the lightning activity produced enough radiation at these frequencies to cause measured levels of interference which could potentially impair satellite communications. Our interpretation of the EFM data is that intensive vertical forcing and rotation in the thunderstorm during the tornado formation caused the observed rapid electric field oscillations. At the same time, the vertical mixing in the storm caused a surge in lightning activity rates recorded by the Boltek and Vaisala sensors. Following the tornado touchdown, there was a rapid decrease in the lightning rates from the sensors. The EFM oscillations also abruptly ceased and went to a more normal slow-varying pattern typically observed during other thunderstorms without associated tornado activity. It is suggested that a network of field mills could provide realtime warning of imminent tornado activity.

  15. Synthesis of nanomagnetic fluids and their UV spectrophotometric response with aliphatic organic acids and 1st tier dendrimers

    Pandya, Shivani R.; Singh, Man

    2016-04-01

    Synthesis of Magnetic nanoparticles were made using coprecipitation method on mixing Fe+3 and Fe+2 in 2:1 ratio with aqueous 8M NaOH which on heating at 90°C for 2 h has yielded 85% magnetic (Fe3O4) nanoparticles (MNPs), characterized by XRD, VSM, SEM, and HR-TEM. The formic acid (FA), oxalic acid (OA) and citric acid (CA), the series of aliphatic organic acids along with Trimesoyl 1, 3, 5 tridimethyl malonate (TTDMM), trimesoyl 1, 3, 5 tridiethyl malonate (TTDEM), trimesoyl 1, 3, 5 tridipropyl malonate (TTDPM), trimesoyl 1, 3, 5 tridibutyl malonate (TTDBM) and trimesoyl 1, 3, 5 tridihexyl malonate (TTDHM) 1st tier dendrimers were used separately for preparing nanomagnetic fluid. From 25 to 150 µM MNPs at an interval of 25 µM were dispersed in 150 µM of acids and dendrimers separately with DMSO. UV-VIS spectrophotometry showed a maximum MNPs dispersion with TTDMM against others and found to be most stable nanomagnetic fluid on account of capping type mechanism of acids.

  16. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies

    Kramar, Peter

    2016-01-01

    This volume presents the proceedings of the 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies (WC2015). The congress took place in Portorož, Slovenia, during the week of September 6th to 10th, 2015. The scientific part of the Congress covered different aspects of electroporation and related technologies and included the following main topics:   ·         Application of pulsed electric fields technology in food: challenges and opportunities ·         Electrical impedance measurement for assessment of electroporation yield ·         Electrochemistry and electroporation ·         Electroporation meets electrostimulation ·         Electrotechnologies for food and biomass treatment ·         Food and biotechnology applications ·         In vitro electroporation - basic mechanisms ·         Interfacial behaviour of lipid-assemblies, membranes and cells in electric f...

  17. 1st Quarter Transportation Report FY 2015: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Gregory, Louis [National Security Technologies, LLC, Las Vegas, NV (United States)

    2015-02-20

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to and from the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 1st quarter of Fiscal Year (FY) 2015 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report include minor volumes of non-radioactive classified waste/material that were approved for disposal (non-radioactive classified or nonradioactive classified hazardous). Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to rounding conventions for volumetric conversions from cubic meters to cubic feet.

  18. Embryonic development of chicken (Gallus Gallus Domesticus) from 1st to 19th day-ectodermal structures.

    Toledo Fonseca, Erika; De Oliveira Silva, Fernanda Menezes; Alcântara, Dayane; Carvalho Cardoso, Rafael; Luís Franciolli, André; Sarmento, Carlos Alberto Palmeira; Fratini, Paula; José Piantino Ferreira, Antônio; Miglino, Maria Angélica

    2013-12-01

    Birds occupy a prominent place in the Brazilian economy not only in the poultry industry but also as an animal model in many areas of scientific research. Thus the aim of this study was to provide a description of macro and microscopic aspects of the ectoderm-derived structures in chicken embryos / fetuses poultry (Gallus gallus domesticus) from 1st to 19th day of incubation. 40 fertilized eggs, from a strain of domestic chickens, with an incubation period of 2-19 days were subjected to macroscopic description, biometrics, light, and scanning microscopy. All changes observed during the development were described. The nervous system, skin and appendages and organs related to vision and hearing began to be identified, both macro and microscopically, from the second day of incubation. The vesicles from the primitive central nervous system-forebrain, midbrain, and hindbrain-were identified on the third day of incubation. On the sixth day of incubation, there was a clear vascularization of the skin. The optic vesicle was first observed fourth day of development and on the fifth day there was the beginning of the lens formation. Although embryonic development is influenced by animal line as well as external factors such as incubation temperature, this paper provides a chronological description for chicken (Gallus gallus domesticus) during its embryonic development. PMID:24019213

  19. Palaeopathology of human remains of the 1st century BC–3rd century AD from Armenia (Beniamin, Shirakavan I

    Khudaverdyan Anahit Yu.

    2015-06-01

    Full Text Available The aim of this article was to document the pathology of the individuals from the archeological sites of Beniamin and Shirakavan I, Armenia, dated on the 1st century BC - 3rd century AD. The findings revealed that two groups differed in mean age at death of adults. At Beniamin it was 24 years, 40.8 years for males and 30.9 years for females, whereas at Shirakavanit it was 29.3 years, 29.6 years for males and 35.8 years for females. The greatest mortality appeared to have occurred when the children reached the age of one year (Beniamin. The population had high number of young-adult females with a cause of death associated with child-bearing. Very few females survived to old age. Traumatic conditions (63.64% and enamel hypoplasias (57.2% have a high frequency in the skeletal material from Shirakavan. The volume of selection of Shirakavan does not allow itself to so big discussion as it was possible with the Beniamin site. Fewer hypoplasias in Beniamin group indicate that food resources were more abundant and more easily exploited. The small frequency of a periodontal disorder indicates that dental hygiene was good during the Antiquity period. We here report a case of possible pituitary dwarfism and a case of decapitation.

  20. Retrospective study of choroidal melanomas at the 1st Department of Ophthalmology, AHEPA hospital, Thessaloniki, from 2002 to 2011

    A A Chranioti

    2016-01-01

    Full Text Available Aim: Retrospective study of cases of choroidal melanoma examined at the 1st Department of Ophthalmology, University Hospital American Hellenic Educational Progressive Association, during the 10-year period, from January 2002 to December 2011. Materials and Methods: The study group consists of 84 patients (84 eyes with newly diagnosed choroidal melanoma. The documentation of the location and the dimensions of the melanomas, based on B-Ultrasonography findings (apical height, diameter, were included. A total of 58 patients were referred to a specialized center abroad for conservative irradiation therapy. Twenty six eyes were enucleated due to large size of the tumor and the histopathological type was determined. Results: Of the 84 cases, 44 were located at the posterior pole while 40 anteriorly. Based on size, 6% (5/84 were small, 58% (49/84 were medium and 36% (30/84 large. Based on the histopathological analysis of 22 of the 26 eyes enucleated, 36% were mixed-cell, 32% were spindle cell and 27% were epithelioid cell melanomas. Conclusions: Our study is the first documentation and classification of newly diagnosed cases of choroidal melanomas. The large number of mandatory enucleations, due to large size, is surprising. Patients need to be better informed about preventive fundoscopy for diagnosis of asymptomatic melanoma at an earlier stage.

  1. Moving beyond the Lone Scientist: Helping 1st-Grade Students Appreciate the Social Context of Scientific Work Using Stories about Scientists

    Sharkawy, Azza

    2009-01-01

    While several studies have documented young children's (K-2) stereotypic views of scientists and scientific work, few have examined students' views of the social nature of scientific work and the strategies effective in broadening these views. The purpose of this study is to examine how stories about scientists influence 1st-grade students' views…

  2. Diagnostic Online Assessment of Basic IT Skills in 1st-Year Undergraduates in the Medical Sciences Division, University of Oxford

    Sieber, Vivien

    2009-01-01

    Attitude, experience and competence (broadly covered by the European Computer Driving Licence syllabus) in information technology (IT) were assessed in 846 1st-year Medical Sciences Division undergraduates (2003-06) at the start of their first term. Online assessments delivered during induction workshops were presented as an opportunity for…

  3. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Karen Amaral Tavares Pinheiro

    2011-01-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  4. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Karen Amaral Tavares Pinheiro

    2011-09-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  5. Transmission of epi-alleles with MET1-dependent dense methylation in Arabidopsis thaliana.

    Michael Watson

    Full Text Available DNA methylation in plants targets cytosines in three sequence contexts, CG, CHG and CHH (H representing A, C or T. Each of these patterns has traditionally been associated with distinct DNA methylation pathways with CHH methylation being controlled by the RNA dependent DNA methylation (RdDM pathway employing small RNAs as a guide for the de novo DOMAINS REARRANGED METHYLTRANSFERASE (DRM2, and maintenance DNA METHYLTRANSFERASE1 (MET1 being responsible for faithful propagation of CG methylation. Here we report an unusual 'dense methylation' pattern under the control of MET1, with methylation in all three sequence contexts. We identified epi-alleles of dense methylation at a non coding RNA locus (At4g15242 in Arabidopsis ecotypes, with distinct dense methylation and expression characteristics, which are stably maintained and transmitted in genetic crosses and which can be heritably altered by depletion of MET1. This suggests that, in addition to its classical CG maintenance function, at certain loci MET1 plays a role in creating transcriptional diversity based on the generation of independent epi-alleles. Database inspection identified several other loci with MET1-dependent dense methylation patterns. Arabidopsis ecotypes contain distinct epi-alleles of these loci with expression patterns that inversely correlate with methylation density, predominantly within the transcribed region. In Arabidopsis, dense methylation appears to be an exception as it is only found at a small number of loci. Its presence does, however, highlight the potential for MET1 as a contributor to epigenetic diversity, and it will be interesting to investigate the representation of dense methylation in other plant species.

  6. fMRI of the brainstem using dual-echo EPI.

    Beissner, Florian; Deichmann, Ralf; Baudrexel, Simon

    2011-04-15

    The brainstem is the part of the human brain that plays a pivotal role in the maintenance of many critical body functions. Due to the elevated level of cardiogenic noise, few fMRI studies have investigated the brainstem so far. Cardiac-gated echo-planar imaging with acquisition of two echoes per excitation (dual-echo EPI) is one method that significantly reduces cardiogenic noise and, thus, allows for fMRI measurements of the brainstem. As information on optimal preprocessing approaches for brainstem-fMRI data is still scarce, the goal of this study was to compare different combinations of normalization and smoothing procedures as implemented in standard fMRI software packages and to identify the combinations yielding optimal results for dual-echo EPI. 21 healthy subjects were measured while executing a simple motor paradigm to activate the facial and trigeminal motor nucleus in the brainstem. After motion correction and calculation of T(2)*-maps the data were preprocessed with 24 combinations of standard normalization (SPM classic, SPM unified, FSL, ABC) and smoothing procedures (pre-/post-smoothing with 3mm-, 4.5mm- and 6mm-kernel) before undergoing first- and second-level statistical analysis. Activation results were compared for first-level and second-level statistics using two anatomically defined regions of interest. Five methods were found to be sensitive for activation of both nuclei. These included FSL normalization with 3mm and 4.5mm pre-smoothing as well as 3mm post-smoothing, SPM unified normalization with 3mm pre-smoothing and ABC normalization with 4.5mm pre-smoothing. All these methods can be recommended for normalization and smoothing when analyzing fMRI data of the brainstem acquired by cardiac-gated dual-echo EPI. PMID:21256220

  7. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats

    Hongxing Han; Hailong Xiao; Kai Zhang; Zhenmei Lu

    2016-01-01

    The impact of 4-epi-oxytetracycline (4-EOTC), one of the main oxytetracycline (OTC) metabolites, on the gut microbiota and physiological metabolism of Wistar rats was analyzed to explore the dynamic alterations apparent after repeated oral exposure (0.5, 5.0 or 50.0 mg/kg bw) for 15 days as shown by 16S rRNA pyrosequencing and UPLC-Q-TOF/MS analysis. Both principal component analysis and cluster analysis showed consistently altered patterns with distinct differences in the treated groups vers...

  8. Bilateral contributions of the cerebellum to the complex motor tasks on EPI fMRI

    To demonstrate activation signals within the cerebellar cortex and to determine the side of the cerebellar cortex eliciting activation signals in response to complex motor tasks, as seen on EPI fMRI. Seven right-handed subjects (M : F=3 : 4; mean age, 30.3 years) underwent repetitive finger apposition with the dominant right hand. Using a 1.5 T MRI scanner, EPI fMR images were obtained. MR parameters used for EPI fMRI were TR/TE/Flip angle : 0.96 msec/64msec/90 deg FOV 22cm, 128 X 128 matrix, 10 slices, 10mm thickness while those for SE T1 weighted localized images were TR/TE : 450/16, FOV 23cm, 256 X 256 matrix. The paradigm was three sets of alternate resting and moving fingers for six cycles, resulting in times of 360 seconds (10 slices X 15 EPI X 6 cycles = 900 images). Image processing involved the use of a 200mHz Dual Pentium PC with homemade software. T-testing (p < 0.005 approx.= p < 0.0005) and time series analysis were performed, and to verify the locations of activated regions, resulting images were analyzed in a color-coded overlay to reference T1-weighted spin echo coronal images. Percentage change in signal intensity (PCSI) was calculated from the processed data. All normal subjects showed significant activation signals in both the contralateral (left) primary motor cortex (PCSI = 3.12% 0.96) and ipsilateral (right) cerebellar cortex (PCSI = 3.09% ±1.14). Signal activation was detected in the contralateral supplemental motor area (2.91% ±0.82), and motor activation in the anterior upper half of the contralateral cerebellum (PCSI 2.50% ±0.69). The difference in activation signals between both sides of the cerebellar cortex was not statistically significant. All data were matched with time-series analysis. Bilateral cerebellar activation is associated with unilateral complex finger movements, as seen on fMRI. This result may support the recent neurological observation that the cerebellum may exert bilateral effects on motor performance

  9. [2H26]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

    Christian A. Citron

    2013-12-01

    Full Text Available During growth on fully deuterated medium the volatile terpene [2H26]-1-epi-cubenol was released by the actinomycete Streptomyces griseus. This compound represents the first completely deuterated terpene obtained by fermentation. Despite a few previous reports in the literature the operability of this approach to fully deuterated compounds is still surprising, because the strong kinetic isotope effect of deuterium is known to slow down all metabolic processes in living organisms. Potential applications of completely labelled compounds from natural sources in structure elucidation, biosynthetic or pharmacokinetic investigations are discussed.

  10. 77 FR 2734 - Proposed Collection; Comment Request: Solar Cell: A Mobile UV Manager for Smart Phones (NCI)

    2012-01-19

    ... phone application combines personal and behavior data with geo- spatial data (i.e., UV Index forecast... UV Manager for Smart Phones (NCI) SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A... overall goal of the study is to design a smart phone application, Solar Cell, which uses smart...

  11. 77 FR 4334 - Proposed Collection; Comment Request; Solar Cell: A Mobile UV Manager for Smart Phones (NCI)

    2012-01-27

    ... phone application combines personal and behavior data with geo- spatial data (i.e., UV Index forecast... UV Manager for Smart Phones (NCI) SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A... overall goal of the study is to design a smart phone application, Solar Cell, which uses smart...

  12. Dexamethasone protects airway epithelial cell line NCI-H292 against lipopolysaccharide induced endoplasmic reticulum stress and apoptosis

    SHANG Yan; WANG Fang; BAI Chong; HUANG Yi; ZHAO Li-jun; YAO Xiao-peng; LI Qiang; SUN Shu-han

    2011-01-01

    Background Endoplasmic reticulum (ER) stress and ER stress-mediated apoptosis were reported to be involved in the pathogenesis of several diseases. In a recent study, it was reported that the ER stress pathway was activated in the lungs of lipopolysaccharide (LPS)-treated mice. It was also found that the C/EBP homologous protein (CHOP), an apoptosis-related molecule, played a key role in LPS-induced lung damage. The aim of this study was to verify whether LPS could activate the ER stress response in airway epithelial cells and which molecule was involved in the pathway.This study was also aimed at finding new reagents to protect the airway epithelial cells during LPS injury.Methods ER stress markers were observed in LPS-incubated NCI-H292 cells. SiRNA-MUC5AC was transfected into NCI-H292 cells. The effects of dexamethasone and erythromycin were observed in LPS-induced NCI-H292 cells.Results LPS incubation increased the expression of ER stress markers at the protein and mRNA levels. The knockout of MUC5AC in cells attenuated the increase in ER stress markers after incubation with LPS. Dexamethasone and erythromycin decreased caspase-3 activity in LPS-induced NCI-H292 cells.Conclusions LPS may activate ER stress through the overexpression of MUC5AC. Dexamethasone may protect human airway epithelial cells against ER stress-related apoptosis by attenuating the overload of MUC5AC.

  13. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    Soejarto, D.D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with t

  14. 76 FR 28439 - Submission for OMB Review; Comment Request; NCI Cancer Genetics Services Directory Web-Based...

    2011-05-17

    ... was previously published in the Federal Register on March 15, 2011 (76 FR 14034) and allowed 60-days... Genetics Services Directory Web-Based Application Form and Update Mailer Summary: Under the provisions of... Collection: Title: NCI Cancer Genetics Services Directory Web-based Application Form and Update Mailer....

  15. Sisällöntuottojärjestelmä EpiServer CMS 6 R2 sovelluskehittäjän näkökulmasta

    Rouhiainen, Taavi

    2013-01-01

    Insinöörityön aiheena oli sisällöntuottojärjestelmä EpiServer CMS 6 R2 sovelluskehittäjän näkökulmasta. Työn tavoitteena oli luoda selkeä asennus- ja sovelluskehitysohje uusille EpiServerin sovelluskehittäjille. Insinöörityössä tehtiin EpiServer CMS 6 R2:lle sovelluskehitysohje, jossa esiteltiin EpiServerin ohjelmistovaatimukset ja EpiServerin asennus kuvia ja taulukoita apunakäyttäen. Tämän lisäksi työssä käsiteltiin EpiServerille www-komponenttien tekeminen alusta loppuun myös kuvina a...

  16. A learning skills course for the 1st year medical students: an experience at a Saudi medical school

    Siddiqui IA

    2015-03-01

    Full Text Available Imran A Siddiqui,1 Khalid A Bin Abdulrahman,2 Mohammed A Alsultan3 1Department of Medical Education and Postgraduate Studies, Saudi Commission for Health Specialties, Riyadh, Saudi Arabia; 2College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University (IMSIU, Riyadh, Saudi Arabia; 3College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Background: Every year nearly 1,500 students enter into medical program after passing high school and national aptitude exams. However, many students experience frustration, failure, and psychological morbidities like stress, depression, and anxiety because they are not aware of their learning styles or do not have effective learning skills and strategies. The College of Medicine of Al-Imam Muhammad ibn Saud Islamic University has adopted the outcome based, community oriented, Spiral Curriculum. Although the curriculum is innovative, on the other hand, it is very demanding. Objective: The purpose of this paper is to share educational structure and evaluation results of the course on effective learning and study skills for the 1st year medical students. Methods: To prepare our students in order to cope with this demanding but promising curriculum, we conducted an effective and comprehensive learning skills course for 16 weeks in the first semester of year 1 in the medical program. Performance of each student was assessed and the course evaluation was done by students at the end of the course. Results: The attendance of the students throughout the course was over 90%. The average performance of students in the summative assessment was 78% and the course was generally liked by the students. Discussion: Students overall had a positive attitude toward the learning skills course. Majority of the students showed interest in attending the sessions regularly and realized the significance of this course to improve their learning skills. Keywords: medical students, learning

  17. New approaches for improving the production of the 1st and 2nd generation ethanol by yeast.

    Kurylenko, Olena; Semkiv, Marta; Ruchala, Justyna; Hryniv, Orest; Kshanovska, Barbara; Abbas, Charles; Dmytruk, Kostyantyn; Sibirny, Andriy

    2016-01-01

    Increase in the production of 1st generation ethanol from glucose is possible by the reduction in the production of ethanol co-products, especially biomass. We have developed a method to reduce biomass accumulation of Saccharomyces cerevisiae by the manipulation of the intracellular ATP level due to overexpression of genes of alkaline phosphatase, apyrase or enzymes involved in futile cycles. The strains constructed accumulated up to 10% more ethanol on a cornmeal hydrolysate medium. Similar increase in ethanol accumulation was observed in the mutants resistant to the toxic inhibitors of glycolysis like 3-bromopyruvate and others. Substantial increase in fuel ethanol production will be obtained by the development of new strains of yeasts that ferment sugars of the abundant lignocellulosic feedstocks, especially xylose, a pentose sugar. We have found that xylose can be fermented under elevated temperatures by the thermotolerant yeast, Hansenula polymorpha. We combined protein engineering of the gene coding for xylose reductase (XYL1) along with overexpression of the other two genes responsible for xylose metabolism in yeast (XYL2, XYL3) and the deletion of the global transcriptional activator CAT8, with the selection of mutants defective in utilizing ethanol as a carbon source using the anticancer drug, 3-bromopyruvate. Resulted strains accumulated 20-25 times more ethanol from xylose at the elevated temperature of 45°C with up to 12.5 g L(-1) produced. Increase in ethanol yield and productivity from xylose was also achieved by overexpression of genes coding for the peroxisomal enzymes: transketolase (DAS1) and transaldolase (TAL2), and deletion of the ATG13 gene. PMID:26619255

  18. Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values.

    Pisi, Roberta; Tzani, Panagiota; Aiello, Marina; Martinelli, Enrico; Marangio, Emilio; Nicolini, Gabriele; Olivieri, Dario; Chetta, Alfredo

    2013-01-01

    Small airways are relevant to the pathophysiology of asthma. We investigated whether in asthmatic patients with normal forced expiratory volume in the 1st second (FEV(1)) values, impulse oscillometry system (IOS), as a measure of small airway function, contributed additional information to spirometry either at baseline or after bronchodilator, and whether it was related to the disease control. The fall in resistance from 5 to 20 Hz (R5-R20) and reactance at 5 Hz (X5) by IOS and spirometry measures of small airway function (forced expiratory flow at 25-75% [FEF(25-75)] and forced vital capacity/slow inspiratory vital capacity [FVC/SVC]) at baseline and after 400 micrograms of salbutamol were prospectively measured in 33 asthmatic patients (18 women; age range, 18-66 years). Disease control was assessed by the Asthma Control Test (ACT). R5-R20 but not X5 values were significantly related to FEF(25-75) and FVC/SVC values (p < 0.05 for both correlations). When the bronchodilator response was assessed, no correlation was found among IOS and spirometry changes. ACT scores were related to R5-R20, FEF(25-75), and FVC/SVC values (p < 0.01 for all correlations). In asthmatic patients with normal FEV(1) values, R5-R20 values were related to spirometry measures of small airway function. However, when the bronchodilator response was assessed, IOS and spirometry provided quite different results. Moreover, small airway dysfunction, as assessed by IOS and spirometry, was associated with poor disease control and history of asthma exacerbations. The results of this study confirm the value of IOS, as an investigative tool, and suggest that in asthmatic patients with normal FEV(1) values and poor disease control, small airway function should be investigated. PMID:23406931

  19. Cognitive-based approach in teaching 1st year Physics for Life Sciences, including Atmospheric Physics and Climate Change components

    Petelina, S. V.

    2009-12-01

    Most 1st year students who take the service course in Physics - Physics for Life Sciences - in Australia encounter numerous problems caused by such factors as no previous experience with this subject; general perception that Physics is hard and only very gifted people are able to understand it; lack of knowledge of elementary mathematics; difficulties encountered by lecturers in teaching university level Physics to a class of nearly 200 students with no prior experience, diverse and sometime disadvantageous backgrounds, different majoring areas, and different learning abilities. As a result, many students either drop, or fail the subject. In addition, many of those who pass develop a huge dislike towards Physics, consider the whole experience as time wasted, and spread this opinion among their peers and friends. The above issues were addressed by introducing numerous changes to the curriculum and modifying strategies and approaches in teaching Physics for Life Sciences. Instead of a conventional approach - teaching Physics from simple to complicated, topic after topic, the students were placed in the world of Physics in the same way as a newborn child is introduced to this world - everything is seen all the time and everywhere. That created a unique environment where a bigger picture and all details were always present and interrelated. Numerous concepts of classical and modern physics were discussed, compared, and interconnected all the time with “Light” being a key component. Our primary field of research is Atmospheric Physics, in particular studying the atmospheric composition and structure using various satellite and ground-based data. With this expertise and also inspired by an increasing importance of training a scientifically educated generation who understands the challenges of the modern society and responsibilities that come with wealth, a new section on environmental physics has been developed. It included atmospheric processes and the greenhouse

  20. Residual effects of TMOF-Bti formulations against 1 st instar Aedes aegypti Linnaeus larvae outside laboratory

    Saiful AN; Lau MS; Sulaiman S; Hidayatulfathi O

    2012-01-01

    Objective: To evaluate the effectiveness and residual effects of trypsin modulating oostatic factor-Bacillus thuringiensis israeliensis (TMOF-Bti) formulations against Aedes aegypti (Ae. aegypti) (L.) larvae at UKM Campus Kuala Lumpur. Methods: Twenty first instar Ae. aegypti larvae were added in each bucket containing 4 L of water supplied with crushed dried leaf powder as their source of food. Combination of TMOF-Bti in rice husk formulation with the following weights viz 10, 25, 50 and 100 mg, respectively in duplicate was distributed in the buckets; while TMOF-Bti in wettable powder formulation each weighing viz 2, 5, 10 and 20 mg, respectively in duplicate was also placed in the buckets. The control buckets run in duplicate with 4 L of water and 20 first instar Ae. aegypti larvae. All buckets were covered with mosquito netting. Larval mortality was recorded after 24 hours and weekly for five weeks. A new batch of 20 1st instar larvaeAe. aegypti was introduced into each bucket weekly without additional TMOF-Bti rice husk formulation or wettable powder. The experiment was repeated for four times. Results: The result of the study showed that all formulations were very effective on the first two weeks by giving 100%larval mortality for all concentrations applied. The TMOF (2%) + Bti (2%) had a good residual effect until the end of 3rd week, TMOF (4%) + Bti (4%) until 4th week, wettable powder TMOF (20%) + Bti (20%) until the third week. Conclusions: From the results it can be concluded that the TMOF-Bti formulations can be utilized in dengue vector control.

  1. Stress and mental health problems in 1st year medical students: a survey of two medical colleges in Kanpur, India

    Shivendra Jena

    2015-01-01

    Full Text Available Background: Incidence of stress among medical students has been reported to be between high and very high. Medical students in pre-clinical phase are more likely to develop psychological distress than medical students in clinical phase. It may affect academic performance and lead to anxiety, depression and substance abuse. Methods: First year students of one government medical college and one private medical college of Kanpur, Uttar Pradesh, India, were surveyed to find out stress and mental health problems shortly after their admission. Results: The two colleges showed difference in the frequencies of a number of factors- current stress, sleep problem, sad mood, both parents working, parents giving sufficient time, non-participation in extra-curricular activities, sharing problem with their families, having break-up in a romantic relationship and poor relationships with classmates and roommate. More students of the government medical college reported to have current stress compared to the students of the private medical college. While all students of the government medical who had stress since admission did not recover from it, 55.56% of students of the private medical college recovered from it at the time of our survey. Conclusion: a Psychiatry Department of every medical college should be involved in screening 1st year students having stress and mental health problems and managing them. b Medical education should be imparted in more relaxed and fun filled manner to help students cope with the long and difficult course. [Int J Res Med Sci 2015; 3(1.000: 130-134

  2. NCI's national environmental research data collection: metadata management built on standards and preparing for the semantic web

    Wang, Jingbo; Bastrakova, Irina; Evans, Ben; Gohar, Kashif; Santana, Fabiana; Wyborn, Lesley

    2015-04-01

    National Computational Infrastructure (NCI) manages national environmental research data collections (10+ PB) as part of its specialized high performance data node of the Research Data Storage Infrastructure (RDSI) program. We manage 40+ data collections using NCI's Data Management Plan (DMP), which is compatible with the ISO 19100 metadata standards. We utilize ISO standards to make sure our metadata is transferable and interoperable for sharing and harvesting. The DMP is used along with metadata from the data itself, to create a hierarchy of data collection, dataset and time series catalogues that is then exposed through GeoNetwork for standard discoverability. This hierarchy catalogues are linked using a parent-child relationship. The hierarchical infrastructure of our GeoNetwork catalogues system aims to address both discoverability and in-house administrative use-cases. At NCI, we are currently improving the metadata interoperability in our catalogue by linking with standardized community vocabulary services. These emerging vocabulary services are being established to help harmonise data from different national and international scientific communities. One such vocabulary service is currently being established by the Australian National Data Services (ANDS). Data citation is another important aspect of the NCI data infrastructure, which allows tracking of data usage and infrastructure investment, encourage data sharing, and increasing trust in research that is reliant on these data collections. We incorporate the standard vocabularies into the data citation metadata so that the data citation become machine readable and semantically friendly for web-search purpose as well. By standardizing our metadata structure across our entire data corpus, we are laying the foundation to enable the application of appropriate semantic mechanisms to enhance discovery and analysis of NCI's national environmental research data information. We expect that this will further

  3. Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells

    FU Zhong-yan; HAN Jin-xiang; HUANG Hai-yan

    2007-01-01

    Background The treatment of patients with small cell lung cancer (SCLC) is based on chemotherapy. However, the treatment is limited by the development of drug resistance. Emodin has been shown to exhibit an anti-cancer effect. But the molecular mechanism remains unclear. This study was conducted to investigate the effect of emodin on the gene expression profile changes in SCLC NCI-H446 cells.Methods NCI-H446 cells were treated with emodin and cell viability was determined by MTT assay. Cell apoptosis was determined by both flow cytometry and caspase-3 activity assay. The effect of emodin on the gene expression profile of NCI-H446 cells was analyzed using cDNA microarray. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to validate the microarray results.Results Emodin suppressed viability, induced apoptosis and changed cell cycle of NCI-H446 cells. Among the 1262 genes, 10 genes were up-regulated and 8 genes were down-regulated more than 2 folds in NCI-H446 cells when compared with the control cells after treatment with emodin for 12 hours, while 12 genes were up-regulated and 24 genes were down-regulated after treatment with emodin for 24 hours. These genes were involved in metabolism, signal transduction, transcription regulation, cytoskeleton organization, immune response, transport, protein synthesis, cell cycle control, cell adhesion and RNA processing. The RT-PCR results were consistent with those obtained by the microarray.Conclusions Emodin affects the expression of genes involved in various cellular functions and plays important roles in cell apoptosis, tumor metastasis and chemotherapy-resistance, which suggests emodin might become an effective chemopreventive or chemotherapeutic agent for SCLC.

  4. The EpiNo® Device: Efficacy, Tolerability, and Impact on Pelvic Floor-Implications for Future Research.

    Kavvadias, Tilemachos; Hoesli, Irene

    2016-01-01

    Aims. The aim of this review is to provide a comprehensive overview of the available literature on preventing perineal trauma with the EpiNo. Methods. We perfomed a literature research in the MedLine and EMBASE databases for studies referring to EpiNo published between 1990 and 2014, without restrictions for language and study type. Results. Five published studies were identified, regarding the effect of EpiNo on the rate of episiotomy and perineal tears, pelvic floor muscle function, and fetal outcome. The device seems to reduce episiotomy and perineal tears' rate, as well as the risk for levator ani microtrauma and avulsion, though not always statistically significant. It does not seem to have an effect on duration of second stage of labour and fetal outcome. The device is well tolerated and the adverse events are rare and mild. However, design and reporting bias in the reviewed articles do not allow evidence based conclusions. Conclusions. The EpiNo device seems to be promising, with potential positive effects on natural birth, while being uncomplicated to use and without major complications. Well designed, randomized trials are needed in order to understand the effects of EpiNo on pelvic floor and make evidence based recommendations on its use. PMID:26981126

  5. Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis

    Yu-Wei Chen; Han-Hsiang Chen; Tsang-En Wang; Ching-Wei Chang; Chen-Wang Chang; Chih-Jen Wu

    2011-01-01

    AIM: To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients. METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations. RESULTS: When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63). CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.

  6. High resolution T{sub 2}{sup *}-weighted magnetic resonance imaging at 3 Tesla using PROPELLER-EPI

    Kraemer, Martin; Reichenbach, Juergen R. [Jena University Hospital (Germany). Medical Physics Group

    2014-09-01

    We report the application of PROPELLER-EPI for high resolution T{sub 2}{sup *}-weighted imaging with sub-millimeter in-plane resolution on a clinical 3 Tesla scanner. Periodically rotated blades of a long-axis PROPELLER-EPI sequence were acquired with fast gradient echo readout and acquisition matrix of 320 x 50 per blade. Images were reconstructed by using 2D-gridding, phase and geometric distortion correction and compensation of resonance frequency drifts that occurred during extended measurements. To characterize these resonance frequency offsets, short FID calibration measurements were added to the PROPELLER-EPI sequence. Functional PROPELLER-EPI was performed with volunteers using a simple block design of right handed finger tapping. Results indicate that PROPELLER-EPI can be employed for fast, high resolution T{sub 2}{sup *}-weighted imaging provided geometric distortions and possible resonance frequency drifts are properly corrected. Even small resonance frequency drifts below 10 Hz as well as non-corrected geometric distortions degraded image quality substantially. In the initial fMRI experiment image quality and signal-to-noise ratio was sufficient for obtaining high resolution functional activation maps. (orig.)

  7. Effects of motion and b-matrix correction for high resolution DTI with short-axis PROPELLER-EPI

    Aksoy, Murat; Skare, Stefan; Holdsworth, Samantha; Bammer, Roland

    2010-01-01

    Short-axis PROPELLER-EPI (SAP-EPI) has been proven to be very effective in providing high-resolution diffusion-weighted and diffusion tensor data. The self-navigation capabilities of SAP-EPI allow one to correct for motion, phase errors, and geometric distortion. However, in the presence of patient motion, the change in the effective diffusion-encoding direction (i.e. the b-matrix) between successive PROPELLER ‘blades’ can decrease the accuracy of the estimated diffusion tensors, which might result in erroneous reconstruction of white matter tracts in the brain. In this study, we investigate the effects of alterations in the b-matrix as a result of patient motion on the example of SAP-EPI DTI and eliminate these effects by incorporating our novel single-step non-linear diffusion tensor estimation scheme into the SAP-EPI post-processing procedure. Our simulations and in-vivo studies showed that, in the presence of patient motion, correcting the b-matrix is necessary in order to get more accurate diffusion tensor and white matter pathway reconstructions. PMID:20222149

  8. 激素冲击疗法治疗Epi-LASIK术后haze的临床研究%Clinical observation of haze after Epi-LASIK operation by high-dose glucocorticoids

    陆岩; 曹哲瑶; 夏丽坤

    2011-01-01

    目的:观察短期大剂量应用高浓度激素冲击疗法减轻或消除Epi-LASIK术后角膜上皮下雾状混浊(haze)的疗效.方法:选取Epi-LASIK术后双眼出现2~3级haze的患者16例32眼,右眼滴用1g/L氟米龙(氟美瞳)眼液冲击治疗,左眼非冲击治疗作为对比.结果:治疗3mo后,与左眼相比右眼haze减轻更显著,视力提高更明显.结论:氟美瞳冲击疗法治疗Epi-LASIK术后haze可缩短治疗时间,提高疗效,且并发症少,值得推广应用.

  9. Scan Time Reduction for Readout-Segmented EPI Using Simultaneous Multislice Acceleration: Diffusion-Weighted Imaging at 3 and 7 Tesla

    Frost, Robert; Jezzard, Peter; Douaud, Gwenaëlle; Clare, Stuart; Porter, David A.; Miller, Karla L.

    2016-01-01

    Purpose Readout-segmented echo-planar imaging (rs-EPI) can provide high quality diffusion data because it is less prone to distortion and blurring artifacts than single-shot echo-planar imaging (ss-EPI), particularly at higher resolution and higher field. Readout segmentation allows shorter echo-spacing and echo train duration, resulting in reduced image distortion and blurring, respectively, in the phase-encoding direction. However, these benefits come at the expense of longer scan times because the segments are acquired in multiple repetitions times (TRs). This study shortened rs-EPI scan times by reducing the TR duration with simultaneous multislice acceleration. Methods The blipped-CAIPI method for slice acceleration with reduced g-factor SNR loss was incorporated into the diffusion-weighted rs-EPI sequence. The rs- and ss-EPI sequences were compared at a range of resolutions at both 3 and 7 Tesla in terms of image fidelity and diffusion postprocessing results. Results Slice-accelerated clinically useful trace-weighted images and tractography results are presented. Tractography analysis showed that the reduced artifacts in rs-EPI allowed better discrimination of tracts than ss-EPI. Conclusion Slice acceleration reduces rs-EPI scan times providing a practical alternative to diffusion-weighted ss-EPI with reduced distortion and high resolution. PMID:25078777

  10. Self-feeding MUSE: a robust method for high resolution diffusion imaging using interleaved EPI.

    Zhang, Zhe; Huang, Feng; Ma, Xiaodong; Xie, Sheng; Guo, Hua

    2015-01-15

    Single-shot echo planar imaging (EPI) with parallel imaging techniques has been well established as the most popular method for clinical diffusion imaging, due to its fast acquisition and motion insensitivity. However, this approach is limited by the relatively low spatial resolution and image distortion. Interleaved EPI is able to break the limitations but the phase variations among different shots must be considered for artifact suppression. The introduction of multiplexed sensitivity-encoding (MUSE) can address the phase issue using sensitivity encoding (SENSE) for self-navigation of each interleave. However, MUSE has suboptimal results when the number of shots is high. To achieve higher spatial resolution and lower geometric distortion, we introduce two new schemes into the MUSE framework: 1) a self-feeding mechanism is adopted by using prior information regularized SENSE in order to obtain reliable phase estimation; and 2) retrospective motion detection and data rejection strategies are performed to exclude unusable data corrupted by severe pulsatile motions. The proposed method is named self-feeding MUSE (SF-MUSE). Experiments on healthy volunteers demonstrate that this new SF-MUSE approach provides more accurate motion-induced phase estimation and fewer artifacts caused by data corruption when compared with the original MUSE method. SF-MUSE is a robust method for high resolution diffusion imaging and suitable for practical applications with reasonable scan time. PMID:25451470

  11. Sampling strategies for subsampled segmented EPI PRF thermometry in MR guided high intensity focused ultrasound

    Odéen, Henrik, E-mail: h.odeen@gmail.com; Diakite, Mahamadou [Department of Physics and Astronomy, University of Utah, Salt Lake City, Utah 84108 and Department of Radiology, University of Utah, Salt Lake City, Utah 84108 (United States); Todd, Nick; Minalga, Emilee; Payne, Allison; Parker, Dennis L. [Department of Radiology, University of Utah, Salt Lake City, Utah 84108 (United States)

    2014-09-15

    Purpose: To investigate k-space subsampling strategies to achieve fast, large field-of-view (FOV) temperature monitoring using segmented echo planar imaging (EPI) proton resonance frequency shift thermometry for MR guided high intensity focused ultrasound (MRgHIFU) applications. Methods: Five different k-space sampling approaches were investigated, varying sample spacing (equally vs nonequally spaced within the echo train), sampling density (variable sampling density in zero, one, and two dimensions), and utilizing sequential or centric sampling. Three of the schemes utilized sequential sampling with the sampling density varied in zero, one, and two dimensions, to investigate sampling the k-space center more frequently. Two of the schemes utilized centric sampling to acquire the k-space center with a longer echo time for improved phase measurements, and vary the sampling density in zero and two dimensions, respectively. Phantom experiments and a theoretical point spread function analysis were performed to investigate their performance. Variable density sampling in zero and two dimensions was also implemented in a non-EPI GRE pulse sequence for comparison. All subsampled data were reconstructed with a previously described temporally constrained reconstruction (TCR) algorithm. Results: The accuracy of each sampling strategy in measuring the temperature rise in the HIFU focal spot was measured in terms of the root-mean-square-error (RMSE) compared to fully sampled “truth.” For the schemes utilizing sequential sampling, the accuracy was found to improve with the dimensionality of the variable density sampling, giving values of 0.65 °C, 0.49 °C, and 0.35 °C for density variation in zero, one, and two dimensions, respectively. The schemes utilizing centric sampling were found to underestimate the temperature rise, with RMSE values of 1.05 °C and 1.31 °C, for variable density sampling in zero and two dimensions, respectively. Similar subsampling schemes

  12. Sampling strategies for subsampled segmented EPI PRF thermometry in MR guided high intensity focused ultrasound

    Purpose: To investigate k-space subsampling strategies to achieve fast, large field-of-view (FOV) temperature monitoring using segmented echo planar imaging (EPI) proton resonance frequency shift thermometry for MR guided high intensity focused ultrasound (MRgHIFU) applications. Methods: Five different k-space sampling approaches were investigated, varying sample spacing (equally vs nonequally spaced within the echo train), sampling density (variable sampling density in zero, one, and two dimensions), and utilizing sequential or centric sampling. Three of the schemes utilized sequential sampling with the sampling density varied in zero, one, and two dimensions, to investigate sampling the k-space center more frequently. Two of the schemes utilized centric sampling to acquire the k-space center with a longer echo time for improved phase measurements, and vary the sampling density in zero and two dimensions, respectively. Phantom experiments and a theoretical point spread function analysis were performed to investigate their performance. Variable density sampling in zero and two dimensions was also implemented in a non-EPI GRE pulse sequence for comparison. All subsampled data were reconstructed with a previously described temporally constrained reconstruction (TCR) algorithm. Results: The accuracy of each sampling strategy in measuring the temperature rise in the HIFU focal spot was measured in terms of the root-mean-square-error (RMSE) compared to fully sampled “truth.” For the schemes utilizing sequential sampling, the accuracy was found to improve with the dimensionality of the variable density sampling, giving values of 0.65 °C, 0.49 °C, and 0.35 °C for density variation in zero, one, and two dimensions, respectively. The schemes utilizing centric sampling were found to underestimate the temperature rise, with RMSE values of 1.05 °C and 1.31 °C, for variable density sampling in zero and two dimensions, respectively. Similar subsampling schemes

  13. Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy

    Boron neutron capture therapy (BNCT) is a promising cancer therapy. Epi-thermal neutron (0.5 eV < En < 10 keV) flux intensity is one of the basic characteristics for modern BNCT. In this work, based on the 71Ga(n, γ)72Ga reaction, a new simple monitor with gallium nitride (GaN) wafer as activation material was designed by Monte Carlo simulations to precisely measure the absolute integral flux intensity of epi-thermal neutrons especially for practical BNCT. In the monitor, a GaN wafer was positioned in the center of a polyethylene sphere as neutron moderator covered with cadmium (Cd) layer as thermal neutron absorber outside. The simulation results and related analysis indicated that the epi-thermal neutron flux intensity could be precisely measured by the presently designed monitor. (author)

  14. Creating Research-Rich Learning Experiences and Quantitative Skills in a 1st Year Earth Systems Course

    King, P. L.; Eggins, S.; Jones, S.

    2014-12-01

    We are creating a 1st year Earth Systems course at the Australian National University that is built around research-rich learning experiences and quantitative skills. The course has top students including ≤20% indigenous/foreign students; nonetheless, students' backgrounds in math and science vary considerably posing challenges for learning. We are addressing this issue and aiming to improve knowledge retention and deep learning by changing our teaching approach. In 2013-2014, we modified the weekly course structure to a 1hr lecture; a 2hr workshop with hands-on activities; a 2hr lab; an assessment piece covering all face-to-face activities; and a 1hr tutorial. Our new approach was aimed at: 1) building student confidence with data analysis and quantitative skills through increasingly difficult tasks in science, math, physics, chemistry, climate science and biology; 2) creating effective learning groups using name tags and a classroom with 8-person tiered tables; 3) requiring students to apply new knowledge to new situations in group activities, two 1-day field trips and assessment items; 4) using pre-lab and pre-workshop exercises to promote prior engagement with key concepts; 5) adding open-ended experiments to foster structured 'scientific play' or enquiry and creativity; and 6) aligning the assessment with the learning outcomes and ensuring that it contains authentic and challenging southern hemisphere problems. Students were asked to design their own ocean current experiment in the lab and we were astounded by their ingenuity: they simulated the ocean currents off Antarctica; varied water density to verify an equation; and examined the effect of wind and seafloor topography on currents. To evaluate changes in student learning, we conducted surveys in 2013 and 2014. In 2014, we found higher levels of student engagement with the course: >~80% attendance rates and >~70% satisfaction (20% neutral). The 2014 cohort felt that they were more competent in writing

  15. Delivery of Epidermal Neural Crest Stem Cells (EPI-NCSC) to hippocamp in Alzheimer's Disease Rat Model

    Esmaeilzade, Banafshe; Nobakht, Maliheh; Joghataei, Mohammad Taghi; Rahbar Roshandel, Nahid; Rasouli, Homa; Samadi Kuchaksaraei, Ali; Hosseini, Seyed Mohammad; Najafzade, Nowruz; Asalgoo, Sara; Hejazian, Leila Beygom; Ghoroghi, Fatima Moghani

    2012-01-01

    Background: Alzheimer’s disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model. Methods: Two weeks after induction of AD by injection of Amyloid-β 1-40 into CA1 area of rat hippocamp, Y-maze and single-trial passive avoidance tests were used to show deficit of learning a...

  16. Diffusion-weighted MRI of the Prostate: Advantages of Zoomed EPI with Parallel-transmit-accelerated 2D-selective Excitation Imaging

    Thierfelder, Kolja M.; Scherr, Michael K.; Weiss, Jakob; Mueller-Lisse, Ullrich G.; Theisen, Daniel [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); Notohamiprodjo, Mike; Nikolaou, Konstantin [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); University Hospital Tuebingen, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany); Dietrich, Olaf [Ludwig-Maximilians-University Hospital Munich, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Munich (Germany); Pfeuffer, Josef [Siemens Healthcare, Application Development, Erlangen (Germany)

    2014-12-15

    The purpose of our study was to evaluate the use of 2D-selective, parallel-transmit excitation magnetic resonance imaging (MRI) for diffusion-weighted echo-planar imaging (pTX-EPI) of the prostate, and to compare it to conventional, single-shot EPI (c-EPI). The MRI examinations of 35 patients were evaluated in this prospective study. PTX-EPI was performed with a TX-acceleration factor of 1.7 and a field of view (FOV) of 150 x 90 mm{sup 2}, whereas c-EPI used a full FOV of 380 x 297 mm{sup 2}. Two readers evaluated three different aspects of image quality on 5-point Likert scales. To quantify distortion artefacts, maximum diameters and prostate volume were determined for both techniques and compared to T2-weighted imaging. The zoomed pTX-EPI was superior to c-EPI with respect to overall image quality (3.39 ± 0.62 vs 2.45 ± 0.67) and anatomic differentiability (3.29 ± 0.65 vs 2.41 ± 0.65), each with p < 0.0001. Artefacts were significantly less severe in pTX-EPI (0.93 ± 0.73 vs 1.49 ± 1.08), p < 0.001. The quantitative analysis yielded a higher agreement of pTX-EPI with T2-weighted imaging than c-EPI with respect to coronal (ICCs: 0.95 vs 0.93) and sagittal (0.86 vs 0.73) diameters as well as prostate volume (0.94 vs 0.92). Apparent diffusion coefficient (ADC) values did not differ significantly between the two techniques (p > 0.05). Zoomed pTX-EPI leads to substantial improvements in diffusion-weighted imaging (DWI) of the prostate with respect to different aspects of image quality and severity of artefacts. (orig.)

  17. The quest for the best: The impact of different EPI sequences on the sensitivity of random effect fMRI group analyses.

    Kirilina, Evgeniya; Lutti, Antoine; Poser, Benedikt A; Blankenburg, Felix; Weiskopf, Nikolaus

    2016-02-01

    We compared the sensitivity of standard single-shot 2D echo planar imaging (EPI) to three advanced EPI sequences, i.e., 2D multi-echo EPI, 3D high resolution EPI and 3D dual-echo fast EPI in fixed effect and random effects group level fMRI analyses at 3T. The study focused on how well the variance reduction in fixed effect analyses achieved by advanced EPI sequences translates into increased sensitivity in the random effects group level analysis. The sensitivity was estimated in a functional MRI experiment of an emotional learning and a reward based learning tasks in a group of 24 volunteers. Each experiment was acquired with the four different sequences. The task-related response amplitude, contrast level and respective t-value were proxies for the functional sensitivity across the brain. All three advanced EPI methods increased the sensitivity in the fixed effects analyses, but standard single-shot 2D EPI provided a comparable performance in random effects group analysis when whole brain coverage and moderate resolution are required. In this experiment inter-subject variability determined the sensitivity of the random effects analysis for most brain regions, making the impact of EPI pulse sequence improvements less relevant or even negligible for random effects analyses. An exception concerns the optimization of EPI reducing susceptibility-related signal loss that translates into an enhanced sensitivity e.g. in the orbitofrontal cortex for multi-echo EPI. Thus, future optimization strategies may best aim at reducing inter-subject variability for higher sensitivity in standard fMRI group studies at moderate spatial resolution. PMID:26515905

  18. Understanding Stress-Related Behavioral Phenotypes: Report from the 1st International Neuroscience Summer School and the 11th International “Stress and Behavior” Conference

    LaPorte, J. L.; V. M. Klimenko; Kalueff, A.V.

    2008-01-01

    The 1st International Neuroscience Summer School and the 11th International Multidisciplinary Neuroscience and Biopsychiatry Conference on Stress and Behavior were held in St. Petersburg, Russia, during May 9–20, 2008. The summer school gathered 30 talented young scientists from 15 countries worldwide, and was dedicated to different topics of behavioral neuroscience. Many interactive courses were provided on neuropharmacology, animal phenotyping, and biopsychology. The conference's excellent ...

  19. Specialty preferences of 1st year medical students in a Saudi Medical School – Factors affecting these choices and the influence of gender

    Kaliyadan, Feroze; Amin, Tarek Tawfik; Qureshi, Habib; al Wadani, Fahad

    2015-01-01

    Background and Aims: In recent years there has been a growing appreciation of the issues of career preference in medicine as it affects student learning and academic performance. Various factors influence the specialty choices of medical students. Some specialties tend to attract students more than others. One possible consequence of this would be a mismatch between health needs and specialist numbers in the region. This study investigated the career preferences of 1st year medical students i...

  20. The 1st Law of Thermodynamics for the Mean Energy of a Closed Quantum System in the Aharonov-Vaidman Gauge

    Allen D. Parks

    2015-06-01

    Full Text Available The Aharonov-Vaidman gauge additively transforms the mean energy of a quantum mechanical system into a weak valued system energy. In this paper, the equation of motion of this weak valued energy is used to provide a mathematical statement of an extended 1st Law of Thermodynamics that is applicable to the mean energy of a closed quantum system when the mean energy is expressed in the Aharonov-Vaidman gauge, i.e., when the system’s energy is weak valued. This is achieved by identifying the generalized heat and work exchange terms that appear in the equation of motion for weak valued energy. The complex valued contributions of the additive gauge term to these generalized exchange terms are discussed and this extended 1st Law is shown to subsume the usual 1st Law that is applicable for the mean energy of a closed quantum system. It is found that the gauge transformation introduces an additional energy uncertainty exchange term that—while it is neither a heat nor a work exchange term—is necessary for the conservation of weak valued energy. A spin-1/2 particle in a uniform magnetic field is used to illustrate aspects of the theory. It is demonstrated for this case that the extended 1st Law implies the existence of a gauge potential ω and that it generates a non-vanishing gauge field F. It is also shown for this case that the energy uncertainty exchange accumulated during the evolution of the system along a closed evolutionary cycle C in an associated parameter space is a geometric phase. This phase is equal to both the path integral of ω along C and the integral of the flux of F through the area enclosed by C.

  1. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Pharmacology”

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (...

  2. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Brain & Development”

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT), supp...

  3. Study of improvement in 1st ring`s gas-seal; Top ring no gas seal seino kojo no kento

    Ando, H.; Tateishi, Y.; Fujimura, K.; Hitosugi, H. [Nippon Piston Ring Co. Ltd., Tokyo (Japan)

    1997-10-01

    The authors studied the effect of an angle of 1st ring twist on the amount of blow-by concerning higher speed/higher output engines for motorcycles. As a result, the authors found the twist made the ring restrained in a ring groove of piston , and confirmed its suitable range for blow-by. By means of the developed optimization method, the authors have achieved significant reduction in blow-by at high engine speed. 1 ref., 9 figs., 2 tabs.

  4. Summary report of the 1st research coordination meeting on nuclear model parameter testing for nuclear data evaluation (Reference Input Parameter Library: Phase II)

    The report describes findings and conclusions of the 1st Research Coordination Meeting on Nuclear Model Parameter Testing for Nuclear Data Evaluation (Reference Input Parameter Library: Phase II). In particular, a critical review of the RIPL Starter File was performed, and a detailed scope and workplan of the RIPL-II project were prepared. In an appendix are included the extended abstracts of four technical papers presented at the meeting. A separate abstract was prepared for each paper

  5. High-Level Cross-Resistance to Didanosine Observed in South African Children Failing an Abacavir- or Stavudine-Based 1st-Line Regimen

    Kim Steegen; Leon Levin; Irene Ketseoglou; Michelle Bronze; Papathanasopoulos, Maria A.; Sergio Carmona; Wendy Stevens

    2014-01-01

    BACKGROUND: The knowledge-base of emerging drug resistance profiles in children exposed to abacavir-based antiretroviral regimens in South Africa is very limited. This study investigated the suitability of didanosine-based 2nd-line regimens for children in the context of antiretroviral drug resistance patterns emerging after 1st-line virologic failure. METHODS: A retrospective dataset of 354 antiretroviral drug resistant genotypes from children failing either abacavir (n = 81) or stavudine (n...

  6. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Other”

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT),...

  7. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Pulmonology”

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (...

  8. The analysis of the physical statement of cadets of the 1st course of the military Institute on the starting stage of studying

    Ovcharuk I.S.

    2010-11-01

    Full Text Available The physical state of the youth which fulfills the rows of military forces of Ukraine has no tendency to improve according to the health and physical preparation. The physical state of cadets of the 1st course is analyzed. 69 cadets took part in research. It improves from the first month of being in educational establishment. Studying curriculum of this educational establishment must provide the fulfillment of all the tasks of physical preparation of military forces of Ukraine.

  9. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Epidemiology”

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT),...

  10. “ASSESSMENT OF DIFFERENT TEACHING AIDS AND TEACHING METHODS FOR THE BETTER PERCEPTION OF BIOCHEMISTRY B Y 1 ST MBBS STUDENTS”

    Priyadarshini; Shetty; Reena

    2012-01-01

    ABSTRACT: BACKGROUND: Medical students during their first year of MBBS c ourse, find Biochemistry difficult and volatile. In this regard , we studied the feedback from students about the effectiveness of prevailing teaching aids and me thods, so that best teaching aid and method can be adopted to improve their academic performance. METHODS: This study comprises of total 117 students of 1st MBBS course, who have com pleted the 2nd semester of academic year 2...

  11. EVALUATION OF ANXIETY & DEPRESSIVE SYMPTOMS IN PATIENTS WITH 1 ST EPISODE OF CHEST PAIN ATTENDING MEDICINE OUT PATIENT DEPARTMENT OF TERTIARY CARE TEACHING HOSPITAL

    Bhavik S.

    2015-06-01

    Full Text Available INTRODUCTION: As chest pain is an important symptom of coronary artery disease (CAD and other non - cardiac diseases , the presentation of the symptom often prompts referral to physicians for further investigation. Previous studies h ad shown significant as sociation between chest pain and D e pr e ssive and anxiety symptoms. AIMS AND OBJECTIVES: Evaluate and screen depressive symptoms , anxiety symptoms and somatic symptoms in patients with 1 st episode of chest pain attending medicine out - patient department of tertiary care teaching hospital. METHODOLGY : Cross - sectional observational study. Prior permission from institutional ethics committee of ‘SUMANDEEP VIDYAPEETH’ had been taken. 100 patients having first episosde of chest pain coming to M edicine opd of DHIRAJ HOSPITAL are recruited randomly after 1st December 2014. Each patient is given case r eport form containing sociodemographic data , patients medical history , depression and somatic symptoms scale and Hamilton’s anxiety scale (HAM - A. All data are entered in spss 16 and analysed with different ( S tatistical tests. Differences on categorical m easures will be reported as P value. The result is significant if P <0.05. RESULT: 38% & 49% patients have clinically significant depression and anxiety respectively. DSSS score is positively correlated with duration of chest pain. CONCLUSION : significant level of depression and anxiety found in 1 st episode of chest pain patients.

  12. The rate of symptomatic improvement of congenital nasolacrimal duct obstruction in Japanese infants treated with conservative management during the 1st year of age

    Hirohiko Kakizaki

    2008-06-01

    Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi2, Shinsuke Kinoshita1, Kunihiko Shiraki2, Masayoshi Iwaki11Department of Ophthalmology, Aichi Medical University, Aichi, Japan; 2Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka, JapanAbstract: This study aimed to examine the rate of symptomatic improvement of congenital nasolacrimal duct obstruction (CNLDO in Japanese infants treated with conservative management within the 1st year of age. Thirty-five lacrimal ducts in 27 patients diagnosed with CNLDO were included in the study. During the observational period, lacrimal ducts were massaged. As well, antibiotic eye drops, to be administered 4 times a day, were sometimes prescribed for obvious conjunctivitis. Two lacrimal ducts in 2 patients were probed before the 1st year of age because of dacryocystitis or severe blepharitis; these patients were included in the unimproved group. Twenty-nine lacrimal ducts in 21 patients resolved during the period (82.9%; with 16 lacrimal ducts resolving before six months of age. Therefore, a comparatively high percentage of resolution for CNLDO (82.9% following conservative management was shown before the 1st year of age in Japanese infants.Keywords: congenital nasolacrimal duct obstruction, symptomatic improvement, conservative management, massage, probing

  13. EpiPOD : community vaccination and dispensing model user's guide.

    Berry, M.; Samsa, M.; Walsh, D.; Decision and Information Sciences

    2009-01-09

    EpiPOD is a modeling system that enables local, regional, and county health departments to evaluate and refine their plans for mass distribution of antiviral and antibiotic medications and vaccines. An intuitive interface requires users to input as few or as many plan specifics as are available in order to simulate a mass treatment campaign. Behind the input interface, a system dynamics model simulates pharmaceutical supply logistics, hospital and first-responder personnel treatment, population arrival dynamics and treatment, and disease spread. When the simulation is complete, users have estimates of the number of illnesses in the population at large, the number of ill persons seeking treatment, and queuing and delays within the mass treatment system--all metrics by which the plan can be judged.

  14. The total syntheses of guttiferone A and 6-epi-guttiferone A.

    Horeischi, Fiene; Biber, Nicole; Plietker, Bernd

    2014-03-12

    Polyprenylated polycyclic acylphloroglucinols (PPAP) are a constantly growing class of natural products that exhibit a common bicyclo[3.3.1]nonatrione core and consist of currently more than 200 members. A subclassification among the various natural products of this class includes the position of the exocyclic acyl group, the prenylation grade of the core, and the relative configuration at C-7 within the core. About 10% of the reported structures, however, possess an additional chiral center at C-6. Herein we describe a straightforward access to guttiferone A and epi-guttiferone A, in which full control of stereoselectivity is achieved via conformational control, and a strict separation of framework decorating from framework constructing operations sets the stage for a short 13-step synthesis. PMID:24579977

  15. Development of ultra pure germanium epi layers for blocked impurity band far infrared detectors

    Lutz, M.P.

    1991-05-01

    The main goals of this paper are: (1) To develop a low-pressure CVD (LPCVD) process that allows epitaxial growth at lower temperatures. Lower temperatures will allow the achievement of a sharp dopant profile at the substrate/epi-layer interface. Less out-diffusion from the substrate would allow the use of thinner epitaxial layers, which would lead to a larger depletion width in the photoactive region. LPCVD also avoids, to a great extent, gas-phase nucleation, which would cause Ge particulates to fall onto the wafer surface during growth. (2) To reduce high levels of oxygen and copper present at the wafer interface, as observed by secondary ion mass spectroscopy (SIMS). In order to achieve high-quality epitaxial layers, it is imperative that the substrate surface be of excellent quality. (3) To make and test detectors, after satisfactory epitaxial layers have been made.

  16. Development of ultra pure germanium epi layers for blocked impurity band far infrared detectors

    The main goals of this paper are: (1) To develop a low-pressure CVD (LPCVD) process that allows epitaxial growth at lower temperatures. Lower temperatures will allow the achievement of a sharp dopant profile at the substrate/epi-layer interface. Less out-diffusion from the substrate would allow the use of thinner epitaxial layers, which would lead to a larger depletion width in the photoactive region. LPCVD also avoids, to a great extent, gas-phase nucleation, which would cause Ge particulates to fall onto the wafer surface during growth. (2) To reduce high levels of oxygen and copper present at the wafer interface, as observed by secondary ion mass spectroscopy (SIMS). In order to achieve high-quality epitaxial layers, it is imperative that the substrate surface be of excellent quality. (3) To make and test detectors, after satisfactory epitaxial layers have been made

  17. New insights in oncology: Epi-genetics and cancer stem cells

    Cancer is a multi-etiologic, multistage disease with a prevalent genetic component, which happens when a large number of genes, critical for cell growth, death, differentiation, migration, and metabolic plasticity are altered irreversibly, so as to either 'gain' (oncogenes) or 'lose' (tumour suppressors) their function. Recent discoveries have revealed the previously underestimated etiologic importance of multiple epigenetic, that is to say, reversible factors (histone modifications, DNA methylation, non-coding RNA) involved in the transcriptional and post-transcriptional regulation of proteins, indispensable for the control of cancerous phenotype. Stable alterations of epigenetic machinery ('epi-mutations') turn out to play a critical role at different steps of carcinogenesis. In addition, due to substantial recent progress in stem cell biology, the new concept of cancer stem cells has emerged. This, along with newly discovered epigenetic cancer mechanisms, gives rise to a hope to overcome radio- and chemo-resistance and to eradicate otherwise incurable neoplasms. (authors)

  18. Diffusion-weighted MRI of the Prostate: Advantages of Zoomed EPI with Parallel-transmit-accelerated 2D-selective Excitation Imaging

    The purpose of our study was to evaluate the use of 2D-selective, parallel-transmit excitation magnetic resonance imaging (MRI) for diffusion-weighted echo-planar imaging (pTX-EPI) of the prostate, and to compare it to conventional, single-shot EPI (c-EPI). The MRI examinations of 35 patients were evaluated in this prospective study. PTX-EPI was performed with a TX-acceleration factor of 1.7 and a field of view (FOV) of 150 x 90 mm2, whereas c-EPI used a full FOV of 380 x 297 mm2. Two readers evaluated three different aspects of image quality on 5-point Likert scales. To quantify distortion artefacts, maximum diameters and prostate volume were determined for both techniques and compared to T2-weighted imaging. The zoomed pTX-EPI was superior to c-EPI with respect to overall image quality (3.39 ± 0.62 vs 2.45 ± 0.67) and anatomic differentiability (3.29 ± 0.65 vs 2.41 ± 0.65), each with p 0.05). Zoomed pTX-EPI leads to substantial improvements in diffusion-weighted imaging (DWI) of the prostate with respect to different aspects of image quality and severity of artefacts. (orig.)

  19. BOLD sensitivity and SNR characteristics of parallel imaging-accelerated single-shot multi-echo EPI for fMRI.

    Bhavsar, Saurabh; Zvyagintsev, Mikhail; Mathiak, Klaus

    2014-01-01

    Echo-planar imaging (EPI) is a standard procedure in functional magnetic resonance imaging (fMRI) for measuring changes in the blood oxygen level-dependent (BOLD) signal associated with neuronal activity. The images obtained from fMRI with EPI, however, exhibit signal dropouts and geometric distortions. Parallel imaging (PI), due to its short readout, accelerates image acquisition and might reduce dephasing in phase-encoding direction. The concomitant loss of signal-to-noise ratio (SNR) might be compensated through single-shot multi-echo EPI (mEPI). We systematically compared the temporal SNR and BOLD sensitivity of single echoes (TE=15, 45, and 75ms) and contrast-optimized mEPI with and without PI and mEPI-based denoising. Audio-visual stimulation under natural viewing conditions activated distributed neural networks. Heterogeneous SNR, noise gain, and sensitivity maps emerged. In single echoes, SNR and BOLD sensitivity followed the predicted dependency on echo time (TE) and were reduced under PI. However, the combination of echoes with mEPI recovered the quality parameters and increased BOLD signal changes at circumscribed fronto-polar and deep brain structures. We suggest applying PI only in combination with mEPI to reduce imaging artifacts and conserve BOLD sensitivity. PMID:23954488

  20. Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells

    Sarah Fernandes Teixeira

    2013-12-01

    Full Text Available OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity.METHODS: We used the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay and calculated the combination index for the drugs studied.RESULTS: We found that the use of metformin as monotherapy reduced the metabolic viability of the cell line studied. Combining metformin with cisplatin or etoposide produced a synergistic effect and was more effective than was the use of cisplatin or etoposide as monotherapy.CONCLUSIONS: Metformin, due to its independent effects on liver kinase B1, had antiproliferative effects on the NCI-H460 cell line. When metformin was combined with cisplatin or etoposide, the cell death rate was even higher.

  1. Fast quantitative susceptibility mapping using 3D EPI and total generalized variation.

    Langkammer, Christian; Bredies, Kristian; Poser, Benedikt A; Barth, Markus; Reishofer, Gernot; Fan, Audrey Peiwen; Bilgic, Berkin; Fazekas, Franz; Mainero, Caterina; Ropele, Stefan

    2015-05-01

    Quantitative susceptibility mapping (QSM) allows new insights into tissue composition and organization by assessing its magnetic property. Previous QSM studies have already demonstrated that magnetic susceptibility is highly sensitive to myelin density and fiber orientation as well as to para- and diamagnetic trace elements. Image resolution in QSM with current approaches is limited by the long acquisition time of 3D scans and the need for high signal to noise ratio (SNR) to solve the dipole inversion problem. We here propose a new total-generalized-variation (TGV) based method for QSM reconstruction, which incorporates individual steps of phase unwrapping, background field removal and dipole inversion in a single iteration, thus yielding a robust solution to the reconstruction problem. This approach has beneficial characteristics for low SNR data, allowing for phase data to be rapidly acquired with a 3D echo planar imaging (EPI) sequence. The proposed method was evaluated with a numerical phantom and in vivo at 3 and 7 T. Compared to total variation (TV), TGV-QSM enforced higher order smoothness which yielded solutions closer to the ground truth and prevented stair-casing artifacts. The acquisition time for images with 1mm isotropic resolution and whole brain coverage was 10s on a clinical 3 Tesla scanner. In conclusion, 3D EPI acquisition combined with single-step TGV reconstruction yields reliable QSM images of the entire brain with 1mm isotropic resolution in seconds. The short acquisition time combined with the robust reconstruction may enable new QSM applications in less compliant populations, clinical susceptibility tensor imaging, and functional resting state examinations. PMID:25731991

  2. Efflux pump inhibitors (EPIs as new antimicrobial agents against Pseudomonas aeruginosa

    Momen Askoura

    2011-05-01

    Full Text Available Pseudomonas aeruginosa is an opportunistic human pathogen and one of the leading causes of nosocomial infections worldwide. The difficulty in treatment of pseudomonas infections arises from being multidrug resistant (MDR and exhibits resistance to most antimicrobial agents due to the expression of different mechanisms overcoming their effects. Of these resistance mechanisms, the active efflux pumps in Pseudomonas aeruginosa that belong to the resistance nodulation division (RND plays a very important role in extruding the antibiotics outside the bacterial cells providing a protective means against their antibacterial activity. Beside its role against the antimicrobial agents, these pumps can extrude biocides, detergents, and other metabolic inhibitors. It is clear that efflux pumps can be targets for new antimicrobial agents. Peptidomimetic compounds such as phenylalanine arginyl β-naphthylamide (PAβN have been introduced as efflux pump inhibitors (EPIs; their mechanism of action is through competitive inhibition with antibiotics on the efflux pump resulting in increased intracellular concentration of antibiotic, hence, restoring its antibacterial activity. The advantage of EPIs is the difficulty to develop bacterial resistance against them, but the disadvantage is their toxic property hindering their clinical application. The structure activity relationship of these compounds showed other derivatives from PAβN that are higher in their activity with higher solubility in biological fluids and decreased toxicity level. This raises further questions on how can we compact Pseudomonas infections. Of particular importance, the recent resurgence in the use of older antibiotics such as polymyxins and probably applying stricter control measures in order to prevent their spread in clinical sittings.

  3. PREFACE: 1st Nano-IBCT Conference 2011 - Radiation Damage of Biomolecular Systems: Nanoscale Insights into Ion Beam Cancer Therapy

    Huber, Bernd A.; Malot, Christiane; Domaracka, Alicja; Solov'yov, Andrey V.

    2012-07-01

    The 1st Nano-IBCT Conference entitled 'Radiation Damage in Biomolecular Systems: Nanoscale Insights into Ion Beam Cancer Therapy' was held in Caen, France, in October 2011. The Meeting was organised in the framework of the COST Action MP1002 (Nano-IBCT) which was launched in December 2010 (http://fias.uni-frankfurt.de/nano-ibct). This action aims to promote the understanding of mechanisms and processes underlying the radiation damage of biomolecular systems at the molecular and nanoscopic level and to use the findings to improve the strategy of Ion Beam Cancer Therapy. In the hope of achieving this, participants from different disciplines were invited to represent the fields of physics, biology, medicine and chemistry, and also included those from industry and the operators of hadron therapy centres. Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal healthy tissue, while maximizing cell killing within the tumour. Several ion beam cancer therapy clinical centres are now operating in Europe and elsewhere. However, the full potential of such therapy can only be exploited by better understanding the physical, chemical and biological mechanisms that lead to cell death under ion irradiation. Considering a range of spatio-temporal scales, the proposed action therefore aims to combine the unique experimental and theoretical expertise available within Europe to acquire greater insight at the nanoscopic and molecular level into radiation damage induced by ion impact. Success in this endeavour will be both an important scientific breakthrough and give great impetus to the practical improvement of this innovative therapeutic technique. Ion therapy potentially provides an important advance in cancer therapy and the COST action MP1002 will be very significant in ensuring Europe's leadership in this field, providing the scientific background, required data and mechanistic insight which

  4. Organometallic Iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis.

    Hearn, Jessica M; Romero-Canelón, Isolda; Qamar, Bushra; Liu, Zhe; Hands-Portman, Ian; Sadler, Peter J

    2013-01-01

    Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (Ir(III)) complexes [Ir(Cp(x))(XY)Cl](+/0) (Cp(x) = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cp(x) ring. In comparison, highly potent complex 4 (Cp(x) = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these Ir(III) complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 μM) of the γ-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic Ir(III) complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands. PMID:23618382

  5. Help Desk Manager : aplicació Android per a la gestió d'incidències

    García Puente, Alberto

    2014-01-01

    HDM, Help Desk Manager és una aplicació android que permet crear i gestionar les incidències que es presenten en una empresa. HDM, Help Desk Manager es una aplicación android que permite crear i gestionar las incidencias que se presentan en una empresa. HDM, Help Desk Manager is an application that allows to create and to manage incidents that occur in a company.

  6. Matrine suppresses invasion and metastasis of NCI-H1299 cells by enhancing microRNA-133a expression.

    Liao, Hehe; Zhao, Xixi; Qu, Jinkun; Zhang, Jia; Cai, Hui

    2015-01-01

    Matrine has been proved to inhibit proliferation and induce apoptosis of human lung cancer cells. However, less studies involved in evaluating the effects and mechanism of matrine in cell migration and invasion of lung cancer. This study was aim to investigate the involvement of miR-133a in matrine's anti-invasion and anti-metastasis in lung cancer. MTT assay was used to assess the inhibition of proliferation effects of matrine in NCI-H1299 cells. Migration and invasion abilities of NCI-H1299 cells were investigated by Transwell assays. Expression of miR-133a was detected by real-time PCR. Anti-miR technique was applied to inhibit miR-133a in matrine treated HCI-H1299 cells. Real-time PCR and Western blotting were performed to evaluate the activation of EGFR/Akt/MMP-9 pathway. As results, matrine treatment significantly inhibited proliferation, migration and invasion of NCI-H1299 cells in a concentration-dependent manner, accompanied by significantly elevation of miR-133a expression. However, matrine failed to inhibit the metastatic ability when cells transfected with anti-miR-133a. Matrine treatment also suppressed activation of EGFR/Akt/MMP-9 pathway. The inhibitory effects of matrine on activation of EGFR pathway were also reversed by anti-miR-133a transfection in NCI-H1299 cells. In conclusion, matrine inhibited the invasion and metastasis of lung cancer cell by elevating expression of miR-133a which further suppressed activation of EGFR/Akt/MMP-9 pathway. PMID:26379863

  7. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    Soejarto, D. D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with the collaboration of the Arnold Arboretum and the Bishop Museum. Botanists from these and other institutions collaborated in the field work operation for the program, among others: J.S. BURLEY (A), ...

  8. Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines

    Ching Wai-Ki

    2010-10-01

    Full Text Available Abstract Background Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic reactions suggests a potential way to discover drug targets. Results In this paper, we present a computational method to predict new targets for approved anti-cancer drugs by exploring drug-reaction interactions. We construct a Drug-Reaction Network to provide a global view of drug-reaction interactions and drug-pathway interactions. The recent reconstruction of the human metabolic network and development of flux analysis approaches make it possible to predict each metabolic reaction's cell line-specific flux state based on the cell line-specific gene expressions. We first profile each reaction by its flux states in NCI-60 cancer cell lines, and then propose a kernel k-nearest neighbor model to predict related metabolic reactions and enzyme targets for approved cancer drugs. We also integrate the target structure data with reaction flux profiles to predict drug targets and the area under curves can reach 0.92. Conclusions The cross validations using the methods with and without metabolic network indicate that the former method is significantly better than the latter. Further experiments show the synergism of reaction flux profiles and target structure for drug target prediction. It also implies the significant contribution of metabolic network to predict drug targets. Finally, we apply our method to predict new reactions and possible enzyme targets for cancer drugs.

  9. Pediatric Non Metastatic Non Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTSS): Five Years Experience from NCI-Egypt

    Purpose: Evaluation of demographic, pathological, and clinical patterns in addition to treatment outcome of pediatric NRSTS patients treated at the NCI, Egypt. Procedure: 21 pediatric patients of NRSTS between 2001 and 2006 were included. Clinical and pathological diagnosis and sub typing verification were done. Patients' cohort formed of 3 treatment groups. (1) Patients who underwent complete surgical resection with no adjuvant therapies. (2) Patients who received chemotherapy and complete surgical resection, and group (3) Patients with localized unrersectable tumors for whom systemic chemo- therapy only was given. Demographic, clinico pathological variables, and treatment modalities were statistically evaluated and compared with the outcome. Results: Tumors of unknown histiogenesis followed by MPNST and myxofibrosarcoma were the most frequent tumor subtypes. Low tumor grade was in favor of better outcome. With a median follow up of 2-years; respectively 100% and 81.1% of patients who had complete surgical resection of a localized disease with or without chemo- therapy entered in CR ( p =0.01). Local failure rate was 27.2% among CR patients (n=17). Two patients suffered local recurrance and one had distant disease metastasis. Conclusion: Complete surgical resection with or without chemotherapy is the mainstay of therapy for localized NRSTS. Tumor grade and surgical resection of NRSTS are 2 important predictors of prognosis

  10. Nonlinear Quantitative Radiation Sensitivity Prediction Model Based on NCI-60 Cancer Cell Lines

    Chunying Zhang

    2014-01-01

    Full Text Available We proposed a nonlinear model to perform a novel quantitative radiation sensitivity prediction. We used the NCI-60 panel, which consists of nine different cancer types, as the platform to train our model. Important radiation therapy (RT related genes were selected by significance analysis of microarrays (SAM. Orthogonal latent variables (LVs were then extracted by the partial least squares (PLS method as the new compressive input variables. Finally, support vector machine (SVM regression model was trained with these LVs to predict the SF2 (the surviving fraction of cells after a radiation dose of 2 Gy γ-ray values of the cell lines. Comparison with the published results showed significant improvement of the new method in various ways: (a reducing the root mean square error (RMSE of the radiation sensitivity prediction model from 0.20 to 0.011; and (b improving prediction accuracy from 62% to 91%. To test the predictive performance of the gene signature, three different types of cancer patient datasets were used. Survival analysis across these different types of cancer patients strongly confirmed the clinical potential utility of the signature genes as a general prognosis platform. The gene regulatory network analysis identified six hub genes that are involved in canonical cancer pathways.

  11. In memoriam: an appreciation for the NCI R25T cancer education and career development program.

    Chang, Shine

    2014-06-01

    On September 7, 2013, the NCI R25T award mechanism ended its final "receipt/review/award cycle" after more than two decades shaping the cancer prevention and control workforce. Created in 1991 to respond to a national shortage of cancer prevention and control researchers, the R25T supported innovative institutional programs with specialized curricula preparing individuals for careers as independent scientists for the field. Required elements ensured developing transdisciplinary sensibilities and skills highly suited to team science, including conducting collaborative research with mentors of complementary expertise. R25Ts provided trainee stipends, research, education, and travel funds at levels far higher than T32 National Service Research Awards to attract individuals from diverse disciplines. Graduates are faculty at all academic ranks, and hold leadership positions such as associate directors of cancer prevention and control. Beyond its trainees, R25Ts also recruited into the field other students exposed through courses in specialized prevention curricula, as well as course instructors and trainee mentors, who did not initially consider their work to be relevant to cancer prevention. Although advances are being achieved, prevention efforts are not yet fully realized, and currently unknown is the impact on the workforce of terminating the R25T, including whether it is another barrier to preventing cancer. PMID:24895444

  12. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

    Bedognetti Davide

    2011-10-01

    Full Text Available Abstract Background Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. Methods In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. Results We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Conclusions Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection.

  13. NCI Funding Trends and Priorities in Physical Activity and Energy Balance Research Among Cancer Survivors.

    Alfano, Catherine M; Bluethmann, Shirley M; Tesauro, Gina; Perna, Frank; Agurs-Collins, Tanya; Elena, Joanne W; Ross, Sharon A; O'Connell, Mary; Bowles, Heather R; Greenberg, Deborah; Nebeling, Linda

    2016-01-01

    There is considerable evidence that a healthy lifestyle consisting of physical activity, healthy diet, and weight control is associated with reduced risk of morbidity and mortality after cancer. However, these behavioral interventions are not widely adopted in practice or community settings. Integrating heath behavior change interventions into standard survivorship care for the growing number of cancer survivors requires an understanding of the current state of the science and a coordinated scientific agenda for the future with focused attention in several priority areas. To facilitate this goal, this paper presents trends over the past decade of the National Cancer Institute (NCI) research portfolio, fiscal year 2004 to 2014, by funding mechanism, research focus, research design and methodology, primary study exposures and outcomes, and study team expertise and composition. These data inform a prioritized research agenda for the next decade focused on demonstrating value and feasibility and creating desire for health behavior change interventions at multiple levels including the survivor, clinician, and healthcare payer to facilitate the development and implementation of appropriately targeted, adaptive, effective, and sustainable programs for all survivors. PMID:26547926

  14. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

    Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection

  15. Visual pigment spectra of the comma butterfly, Polygonia c-album, derived from in vivo epi-illumination microspectrophotometry.

    Houtte, K.J.A. van; Stavenga, D.G.

    2005-01-01

    The visual pigments in the compound eye of the comma butterfly, Polygonia c-album, were investigated in a specially designed epi-illumination microspectrophotometer. Absorption changes due to photochemical conversions of the visual pigments, or due to light-independent visual pigment decay and regen

  16. Visual pigment spectra of the comma butterfly, Polygonia c-album, derived from in vivo epi-illumination nation microspectrophotometry

    Vanhoutte, KJA; Stavenga, DG

    2005-01-01

    The visual pigments in the compound eye of the comma butterfly, Polygonia c-album, were investigate in a specially designed epi-illumination microspectrophotometer. Absorption changes due to photochemical conversions of the visual pigments, or due to light-independent visual pigment decay and regene

  17. Analysis of the burden of treatment in patients receiving an EpiPen for yellow jacket anaphylaxis

    Elberink, Joanne N. G. Oude; van der Heide, S.; Guyatt, Gordon H.; Dubois, Anthony E. J.

    2006-01-01

    Background: Venom immunotherapy (VIT) is a treatment with established efficacy for the prevention of repeated anaphylactic reactions in patients with Hymenoptera allergy, which also allows patients to discontinue carrying an EpiPen. Despite their merits, both treatments can have negative aspects pot

  18. epi-Fluorescence imaging at the air-water interface of fibrillization of bovine serum albumin and human insulin.

    Sessions, Kristen; Sacks, Stuart; Li, Shanghao; Leblanc, Roger M

    2014-08-18

    Protein fibrillization is associated with many devastating neurodegenerative diseases. This process has been studied using spectroscopic and microscopic methods. In this study, epi-fluorescence at the air-water interface was developed as an innovative technique for observing fibrillization of bovine serum albumin and human insulin. PMID:24976597

  19. Comparison of volume-selective z-shim and conventional EPI in fMRI studies using face stimuli

    Fukunaga, Hu Cheng Srikanth Padmala Rena

    2013-01-01

    Single-shot gradient recalled echo planar imaging (EPI) is the primary tool for functional magnetic resonance imaging (fMRI). The image often suffers from signal drop near the air-tissue interface, such as the amygdala and regions of the orbitofrontal lobe. An effective way to correct for this type of artifact is by applying multi-shot EPI using different z-shimming. Unfortunately, the scanning efficiency is significantly lowered. More recently, a new technique called volume-selective z-shim was proposed to implement z-shim compensation to only specific slices with large susceptibility effects. The high imaging efficiency of volume selective z-shim makes it possible to substitute conventional EPI for whole brain studies. In this study two fMRI experiments were conducted to compare volume- selective z-shim and conventional EPI while subjects performed tasks on face stimuli. The comparison was focused on three brain regions: amygdala, hippocampus, and fusiform gyrus. Our results indicate that despite fewer volu...

  20. Educational Progress Indicator (E.P.I.): Synthetic Indicator for Monitoring Education. Contribution to Education for All.

    Camara, Boubacar

    This publication complements the "Education for All" program and is intended to provide a comprehensive and operational indicator for monitoring education. As a synthetic tool, the Educational Progress Indicator (EPI) facilitates the analytical assessment and projection work of educational planners, managers, actors, and policymakers. The EPI…

  1. Phospholipid vesicle-based permeation assay and EpiSkin® in assessment of drug therapies destined for skin administration.

    Engesland, André; Škalko-Basnet, Nataša; Flaten, Gøril Eide

    2015-03-01

    Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this study was to determine the ability of the phospholipid vesicle-based permeation assay (PVPA) to assess the effect of different formulations on drug permeability and thus establish its utility in formulation development. Three model drugs were tested in solutions and as liposomal formulations. The permeability results for the PVPA models were compared with the results for the reconstructed human skin model, EpiSkin(®). The drugs were ranked based on their estimated penetration potentials, and the results were in accordance with what was expected considering the physicochemical properties of the drugs. PVPAs (E-80, ceramide, cholesterol, cholesteryl sulfate, and palmitic acid) was able to distinguish between drug solutions and liposomal formulations; however, EpiSkin(®) detected only small differences between the drugs in solution and formulations. In contrast with EpiSkin(®), which is limited by a 3-day testing window, PVPA barriers can be stored frozen for up to 2 weeks or even up to 16 months, depending on their compositions. The PVPA models are thus more cost effective and efficient than the EpiSkin(®) model for permeability screening during early drug development. PMID:25558045

  2. Revisió dels odonats valencians de la col·lecció d’artròpodes del Museu de Ciències Naturals de Barcelona

    Fontana-Bria, L.; Selfa, J.

    2012-01-01

    Revision of Valencian dragonflies in the arthropod collection at the Museu de Ciències Naturals de Barcelona The current work shows the species of Valencian dragonflies preserved in the arthropod collection at the Museu de Ciències Naturals de Barcelona (Spain). The collection contains a total of 33 specimens belonging to 12 species, representing 18% of the known species in the Autonomous Community of Valencia.

  3. Revisió dels odonats valencians de la col·lecció d’artròpodes del Museu de Ciències Naturals de Barcelona

    Fontana-Bria, L.

    2012-07-01

    Full Text Available Revision of Valencian dragonflies in the arthropod collection at the Museu de Ciències Naturals de Barcelona The current work shows the species of Valencian dragonflies preserved in the arthropod collection at the Museu de Ciències Naturals de Barcelona (Spain. The collection contains a total of 33 specimens belonging to 12 species, representing 18% of the known species in the Autonomous Community of Valencia.

  4. Epi-LASIK 和 LASIK 治疗近视散光的早期疗效对比观察%Comparative study of Epi -LASIK and LASIK for myopic astigmatism

    罗栋强; 王华; 何书喜; 陈蛟

    2013-01-01

    AIM: To analyze the effects of epipolis laser in situ keratomileusis ( Epi - LASIK ) and laser in situ keratomileusis ( LASIK ) for treatment of myopic astigmatism. METHODS: For treatment of myopic astigmatism, 32 patients (64 eyes) treated by Epi-LASIK and 63 patients (126 eyes) received LASIK.By their degree of astigmatism, the eyes were divided into GroupⅠ(-0.25~-2.75) DC and GroupⅡ(-3.0~-5.0) DC.During the 6-month follow-up, the early effects of the two operations were observed and compared in terms of uncorrected visual acuity ( UCVA) , best corrected visual acuity ( BCVA ) , residual astigmatism, corneal healing, intraocular pressure ( IOP) , corneal topography. RESULTS: In Group Ⅱ, UCVA better than 20/20 was achieved in 87.5%of the eyes subjected to Epi-LASIK and in 63.3% of the eyes subjected to LASIK, with significant difference between them (χ2 =4.055, P<0.05); residual astigmatism was-0.41±0.30D for the Epi-LASIK eyes and-0.74 ±0.36D for the LASIK eyes, with significant difference between them ( t =2.672, P <0.05 );postoperative corneal astigmatism was 0.63±0.34D for the Epi-LASIK eyes and 0.81 ±0.52D for the LASIK eyes with significant difference between them (t=2.234, P<0.05). CONCLUSION: For treatment of high astigmatism (≥-3 .0 0 D ) , Epi-LASIK is more effective and predictive than LASIK.%目的:探讨分析角膜微型刀上皮瓣下准分子激光原位角膜磨镶术( epipolis laser in situ keratomileusis , Epi-LASIK)和准分子激光原位角膜磨镶术( laser in situ keratomileusis , LASIK)治疗近视散光的疗效。方法:近视散光行 Epi-LASIK 治疗的患者32例64眼, LASIK治疗的患者63例126眼,将患者根据柱镜度数分为2组:Ⅰ组(柱镜-0.25~-2.75D,Epi-LASIK 20例、LASIK 48例)、Ⅱ组(柱镜-3.00~-5.00D,Epi-LASIK 12例、LASIK 15例)。随访6 mo观察两种术式的疗效。对比两组患者的术后裸眼视力( uncorrected visual acuity , UCVA

  5. The comparison of salivary level of estrogen and progesterone in 1 st , 2 nd and 3 rd trimester in pregnant women with and without geographic tongue

    Parichehr Ghalayani

    2013-01-01

    Full Text Available Background: Geographic tongue (GT was first reported as a wandering rash of the tongue in 1831; however, its etiopathogenesis remains unclear. Increased prevalence of GT has been documented in the pregnancy. The aim of this study was to compare the level of salivary estrogen and progesterone in pregnant women with and without GT. Materials and Methods: This analytical-descriptive study consisted of 26 pregnant women (13 with GT, 13 without GT with an age range between 18 years and 45 years. The estrogen and progesterone level was measured during 1 st , 2 nd and 3 rd trimester of pregnancy. Saliva sampling was performed to determine the level of sex hormones. The samples were stored at -80°C and determined by Eliza method. The results were analyzed by t-test and repeated measure ANOVA (α = 0.05. Results: The mean level of estrogen for control and case group was 49.4and 52.33 in the 1 st , 71.05 and 74.12 in the 2 nd and 109.1 and 112.16 in the 3 rd trimester respectively. The mean level of progesterone was 0.72 and 0.72 in the 1 st , 1.14 and 1.21 in the 2 nd and 1.3 and 1.28 in the 3 rd trimester of pregnancy for the control and case groups respectively. Even though, there was no significant difference regarding the level of sex hormones between case and control groups (P > 0.05, but the difference between the level of these hormones during 3 trimesters of pregnancy was significant in each group (P = 0.001. Conclusion: The level of sex hormones is not the only etiologic factor of GT in pregnant women, but other factors such as genetic potential, human leukocyte antigen marker and stress may aggravate the incidence of this lesion.

  6. High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.

    Kim Steegen

    Full Text Available BACKGROUND: The knowledge-base of emerging drug resistance profiles in children exposed to abacavir-based antiretroviral regimens in South Africa is very limited. This study investigated the suitability of didanosine-based 2nd-line regimens for children in the context of antiretroviral drug resistance patterns emerging after 1st-line virologic failure. METHODS: A retrospective dataset of 354 antiretroviral drug resistant genotypes from children failing either abacavir (n = 81 or stavudine (n = 273 based 1st-line regimens, was analysed. Samples were sent to the HIV genotyping laboratory at Charlotte Maxeke Johannesburg Academic Hospital, for routine testing. Pol sequences were submitted to the Stanford HIV drug resistance database for genotypic predictions. RESULTS: Children were exposed to abacavir or stavudine-based 1st-line regimens for an average of 21 and 36 months, respectively. The frequency of reduced susceptibility to didanosine was substantial in the abacavir-exposed group (69.1%.This reduced susceptibility was commonly attributed to L74V/I (n = 44 and to a lesser extent K65R (n = 10 mutations. Didanosine resistance was observed in 43.2% of patients exposed to stavudine-based regimens. In contrast, most children remained susceptible to stavudine regardless of exposure to abacavir (77.8% or stavudine (74.7%. At least 80% of children remained susceptible to zidovudine irrespective of stavudine or abacavir-exposure. The presence of the K65R mutation was more common after abacavir pressure (12.3% vs 1.8%. CONCLUSION: Analysis revealed that didanosine-based 2nd-line regimens have limitations for South African children, given the high frequency of mutations that confer cross-resistance to didanosine; especially after abacavir-exposure. This data has influenced South African paediatric treatment guidelines, which now recommend zidovudine-based 2nd-line regimens.

  7. Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

    Wei Chin-Chuan

    2012-04-01

    Full Text Available Abstract Background Superoxide generated by non-phagocytic NADPH oxidases (NOXs is of growing importance for physiology and pathobiology. The calcium binding domain (CaBD of NOX5 contains four EF-hands, each binding one calcium ion. To better understand the metal binding properties of the 1st and 2nd EF-hands, we characterized the N-terminal half of CaBD (NCaBD and its calcium-binding knockout mutants. Results The isothermal titration calorimetry measurement for NCaBD reveals that the calcium binding of two EF-hands are loosely associated with each other and can be treated as independent binding events. However, the Ca2+ binding studies on NCaBD(E31Q and NCaBD(E63Q showed their binding constants to be 6.5 × 105 and 5.0 × 102 M-1 with ΔHs of -14 and -4 kJ/mol, respectively, suggesting that intrinsic calcium binding for the 1st non-canonical EF-hand is largely enhanced by the binding of Ca2+ to the 2nd canonical EF-hand. The fluorescence quenching and CD spectra support a conformational change upon Ca2+ binding, which changes Trp residues toward a more non-polar and exposed environment and also increases its α-helix secondary structure content. All measurements exclude Mg2+-binding in NCaBD. Conclusions We demonstrated that the 1st non-canonical EF-hand of NOX5 has very weak Ca2+ binding affinity compared with the 2nd canonical EF-hand. Both EF-hands interact with each other in a cooperative manner to enhance their Ca2+ binding affinity. Our characterization reveals that the two EF-hands in the N-terminal NOX5 are Ca2+ specific. Graphical abstract

  8. The Radiological Physics Center: 40 years of vigilance and quality assurance for NCI sponsored clinical trials

    The RPC was established in 1968 to contribute to the development, conduct, and QA of multi-institutional cooperative group clinical trials. One key aspect to the RPC's function is that it operates as an independent quality assurance office for multi-institutional cooperative group clinical trials. The RPC grant was originally awarded through a competition sponsored by the AAPM. In 1967, a memorandum of agreement was reached between the AAPM and the Committee for Radiation Therapy Studies (CRTS) for clinical radiation dosimetry related to inter-institutional studies. The agreement called for the establishment of a center of operations for the implementation of this scientific program, in other words, the creation of a Radiological Physics Center. The RPC has been funded continuously since 1968 under Dr. Shalek's guidance (1968-1985), followed by Dr. William Hanson (1985-2001) and currently by Dr. Geoffrey Ibbott (2001-present). The RPC currently monitors 1768 institutions that participate in cooperative group clinical trials sponsored by the National Cancer Institute (NCI). These institutions are located primarily in the USA and Canada, but also include participants from 30 other countries. Within the 1768 institutions, there are over 3300 megavoltage therapy machines that are monitored by the RPC QA program. In 1999, the RPC joined with several other QA offices to form the Advanced Technology Consortium (ATC). The role of the ATC is to support the development and conduct of advanced technology clinical trials, to facilitate communications among the four QA offices and to reduce duplication of effort among the quality assurance offices. The four major components of the RPC's QA program are: 1) the remote TLD audit of machine calibration, 2) on-site dosimetry review visits, 3) credentialing for advanced technology clinical trials, and 4) review of patient treatment records

  9. Effects of land-use change on the carbon balance of 1st generation biofuels: An analysis for the European Union combining spatial modeling and LCA

    Biofuels are considered as an important option for the mitigation of climate change. However, the negative impact of land-use change (LUC) on soil and vegetation carbon pools may jeopardize the potentially achievable savings of greenhouse gas (GHG) emissions. In this study the impact of GHG emissions from LUC on the overall GHG performance of 1st generation biofuels was analyzed for the European Union (EU). The scenario-based analysis was done by coupling a spatial land-use model to a Life Cycle Assessment (LCA) of biofuels. The biofuel demand in the scenarios was derived from figures for the transport sector of the EU-27 Member States. The calculation of GHG emissions was performed with a Geographic Information System. Finally, these results were integrated into the LCA approach of the EU Renewable Energy Directive (RED). Without taking LUC into account, the average GHG emission saving compared to fossil fuel use amounts to ∼50%. In this case the mandatory 35% emission saving target laid down in the RED would be fulfilled. If LUC is considered, this target is reached under none of the simulated biofuel scenarios. In the most realistic scenario the GHG emission savings from 1st gen. biofuel use compared to fossil fuel use range between −2% and 13%. Based on our findings, we conclude that national policy plans for biofuel use should be reconsidered and revised as in their current form they do not provide an adequate measure for the mitigation of global warming on EU-level. -- Highlights: •We determine LUC due to 1st gen. biofuel production in the EU with a spatial model. •We comprehensively estimate GHG emissions from LUC across a fine resolution grid. •Based on our GHG emission estimates we perform an LCA of 1st gen. biofuel scenarios. •By 2020, the GHG emission savings from biofuel use are considerably below the EU target. •Our analysis questions the contribution of biofuel use to climate change mitigation

  10. Curonian Ethnic Community at the End of 19th Century – 1st Half of 20th Century: Number, Location, Historical Processes

    Krišs Kapenieks

    2013-01-01

    The doctoral thesis „Curonian Ethnic Community at the End of 19th Century – 1st Half of 20th Century: Number, Location, Historical Processes“ has been written at the Chair of Modern and Contemporary History of Latvia and Eastern Europe of the Faculty of History and Philosophy, University of Latvia in 2006–2011. Author: Krišs Kapenieks. Supervisor: Ēriks Jēkabsons, Doctor of History, associate professor at the Chair of Modern and Contemporary History of Latvia and Eastern Europe of the Faculty...

  11. [Influence of hypocaloric diet with addition of a vitamin-mineral complex on status of patients with obesity 1st and 2nd degrees].

    Sharafetdinov, Kh Kh; Plotnikova, O A; Zykina, V V; Mal'tsev, G Iu; Sokol'nikov, A A; Kaganov, B S

    2011-01-01

    Addition of a vitamin-mineral complex (VMC) to a standard hypocaloric diet leads to a positive dynamics of antropometric characteristics in patients with obesity 1st and 2nd degrees which is comparable to effectiveness of standard dietotherapy (dietary treatment) traditionally used in complex treatment of obesity. Addition of 1,8 mg of vitamin B2 as part of VMC to a hypocaloric diet is shown to be inadequate in eradication of marginal provision of riboflavin when using diets reduced in calories. PMID:22232885

  12. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  13. 1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

    Maximilien Brice

    2010-01-01

    1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

  14. Epi Info(R) Now an Open-source application that continues a long and productive life through CDC support and funding

    Enrique Nieves Jr; Jay Jones

    2009-01-01

    The CDC’s National Center for Public Health Informatics (NCPHI) recently released the Epi Info code to the public, making it the first Public Health Information Network (PHIN) application to go open source. Because the code is freely available, other developers and other entities can work with the Epi Info™ code to add features, contribute enhancements, and make it a much better product. Going open source will also help Epi Info grow a wider user base, and as it grows, CDC hopes to attract mo...

  15. Design and Development of Nonlinear Optical Microscope System: Simple Implementation with epi-Illumination Platform

    Ryu Jiheun

    2015-01-01

    Full Text Available During the research using fluorescence-tagged or auto-fluorescence molecules, meaningful information is often buried deep inside the tissue, not its surface. Therefore, especially in the field of biomedical imaging, acquiring optically sectioned images from deep inside the tissue is very important. As well know already, confocal laser scanning microscopy (the most well-known optical sectioning microscopy gives axially-resolved fluorescence information using the physical background blocking component called pinhole. However, the axial range of imaging is practically limited due to such optical phenomena as the light scattered and absorbed in the tissue. However, nonlinear optical microscopy (e.g. Multiphoton microscopy, harmonic generation microscopy, coherent anti-Stokes Raman spectroscopy realized by the development of ultrafast light sources has been used for visualizing various tissues, especially in vivo, because of their low sensitivity to the limitation caused by the scattering and the absorption of light. Although nonlinear optical microscopy gives deep tissue image, it is not easy for many researcher to build customized nonlinear system. Here, we introduce an easy and simple way designing and developing such nonlinear optical microscope with upright or inverted epi-illumination platform using commercial optical components only.

  16. Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI.

    Piero Chiacchiaretta

    Full Text Available Previous evidence showed that, due to refocusing of static dephasing effects around large vessels, spin-echo (SE BOLD signals offer an increased linearity and promptness with respect to gradient-echo (GE acquisition, even at low field. These characteristics suggest that, despite the reduced sensitivity, SE fMRI might also provide a potential benefit when investigating spontaneous fluctuations of brain activity. However, there are no reports on the application of spin-echo fMRI for connectivity studies at low field. In this study we compared resting state functional connectivity as measured with GE and SE EPI sequences at 3T. Main results showed that, within subject, the GE sensitivity is overall larger with respect to that of SE, but to a less extent than previously reported for activation studies. Noteworthy, the reduced sensitivity of SE was counterbalanced by a reduced inter-subject variability, resulting in comparable group statistical connectivity maps for the two sequences. Furthermore, the SE method performed better in the ventral portion of the default mode network, a region affected by signal dropout in standard GE acquisition. Future studies should clarify if these features of the SE BOLD signal can be beneficial to distinguish subtle variations of functional connectivity across different populations and/or treatments when vascular confounds or regions affected by signal dropout can be a critical issue.

  17. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats.

    Han, Hongxing; Xiao, Hailong; Zhang, Kai; Lu, Zhenmei

    2016-01-01

    The impact of 4-epi-oxytetracycline (4-EOTC), one of the main oxytetracycline (OTC) metabolites, on the gut microbiota and physiological metabolism of Wistar rats was analyzed to explore the dynamic alterations apparent after repeated oral exposure (0.5, 5.0 or 50.0 mg/kg bw) for 15 days as shown by 16S rRNA pyrosequencing and UPLC-Q-TOF/MS analysis. Both principal component analysis and cluster analysis showed consistently altered patterns with distinct differences in the treated groups versus the control groups. 4-EOTC treatment at 5.0 or 50.0 mg/kg increased the relative abundance of the Actinobacteria, specifically Bifidobacteriaceae, and improved the synthesis of lysophosphatidylcholine (LysoPC), as shown by the lipid biomarkers LysoPC(16:0), LysoPC(18:3), LysoPC(20:3), and LysoPC(20:4). The metabolomic analysis of urine samples also identified four other decreased metabolites: diacylglycerol, sphingomyelin, triacylglycerol, and phosphatidylglycerol. Notably, the significant changes observed in these biomarkers demonstrated the ongoing disorder induced by 4-EOTC. Blood and urine analysis revealed that residual 4-EOTC accumulated in the rats, even two weeks after oral 4-EOTC administration, ceased. Thus, through thorough analysis, it can be concluded that the alteration of the gut microbiota and disorders in blood metabolomics are correlated with 4-EOTC treatment. PMID:26976662

  18. Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit

    Gerding, H.; Benner, F. P.; Taneri, S.

    2007-03-01

    The purpose of this paper is to investigate the surgical feasibility of implantation and long-term structural outcome of retina implant devices with an anterior IOL receiver, a connecting microcable and posterior segment epiretinal microcontacts. Implantation of epiretinal retina (EPI-RET) implants was performed as a one-step surgical procedure including phacoemulsification and pars plana vitrectomy in two adult rabbits. Implants were mechanically stabilized in an anterior position by the lens capsule and in the posterior segment by microtacks with a soft contact collar. Follow-up (6 and 9 months) included regular clinical examination, anterior and posterior segment photography and finally pathohistological evaluation. Implantation was uneventful in case 1 and complicated by vitreous space haemorrhage in case 2. At the end of follow-up, the retina was partially detached in animal 1 and subtotally detached in animal 2. Common features of tissue reaction in both cases were the formation of cyclitic membranes extending around and posterior to the anterior IOL receiver. In addition to that severe proliferations developed around microcables, microcontacts and microtacks forming a tissue capsule around posterior segment foreign materials. Retinal areas in contact to implant devices presented a severe structural damage and disorganization. Results of this preliminary trial suggest that the application of epiretinal prostheses with large diameter IOL receivers may be a critical issue and can give rise to an unfavourable outcome. Further systematic investigation ought to be performed involving a larger number of animals, modified implants and perhaps other species.

  19. Biotransformation of dehydro-epi-androsterone by Aspergillus parasiticus: Metabolic evidences of BVMO activity.

    Mascotti, M Laura; Palazzolo, Martín A; Bisogno, Fabricio R; Kurina-Sanz, Marcela

    2016-05-01

    The research on the synthesis of steroids and its derivatives is of high interest due to their clinical applications. A particular focus is given to molecules bearing a D-ring lactone like testolactone because of its bioactivity. The Aspergillus genus has been used to perform steroid biotransformations since it offers a toolbox of redox enzymes. In this work, the use of growing cells of Aspergillus parasiticus to study the bioconversion of dehydro-epi-androsterone (DHEA) is described, emphasizing the metabolic steps leading to D-ring lactonization products. It was observed that A. parasiticus is not only capable of transforming bicyclo[3.2.0]hept-2-en-6-one, the standard Baeyer-Villiger monooxygenase (BVMO) substrate, but also yielded testololactone and the homo-lactone 3β-hydroxy-17a-oxa-d-homoandrost-5-en-17-one from DHEA. Moreover, the biocatalyst degraded the lateral chain of cortisone by an oxidative route suggesting the action of a BVMO, thus providing enough metabolic evidences denoting the presence of BVMO activity in A. parasiticus. Furthermore, since excellent biotransformation rates were observed, A. parasiticus is a promising candidate for the production of bioactive lactone-based compounds of steroidal origin in larger scales. PMID:27025973

  20. Final report for the 1st surveillance test of the reactor pressure vessel material (Capsule 2) of Ulchin nuclear power plant unit 3

    Surveillance testing for reactor vessel materials is performed in order to evaluate the irradiation embrittlement due to neutrons during operation and set the condition of safe operation of nuclear reactor. The 1st surveillance testing was performed completely by Korea Atomic Energy Research Institute at Taejon after the capsule was transported from Ulchin site including its removal from reactor. Fast neutron fluences for capsules were calculated and various testing including mechanical and chemistry analysis were performed in order to evaluate the integrity of Ulchin unit 3 reactor vessel during the operation until life time. The evaluation results are as follows: Fast neutron fluences for capsule 2 is 4.674E+18n/cm2. The bias factor, the ratio of calculation/measurement, was 0.920 for the 1st testing and the calculational uncertainty, 7.0% satisfied the requirement of USNRC Reg.Guide 1.190, 20%. The best estimated neutron fluence for reactor vessel inside surface was 3.913E+18n/cm2 based on the end of 6th fuel cycle and it was predicted that the fluences of vessel inside surface at 16 and 32EFPY would reach 9.249E+18 and 1.834E+19n/cm2 based on the current calculation. The result through this analysis for Ulchin unit 3 showed that there would be no problem for the pressurized thermal shock(PTS) during the operation until design life

  1. Final Report for the 1st Surveillance Test of the Reactor Pressure Vessel Material (CAPSULE 2) of Ulchin Nuclear Power Plant Unit 3

    Chang, Kee Ok; Kim, Byoung Chul; Lee, Sam Lai (and others)

    2006-12-15

    Surveillance testing for reactor vessel materials is performed in order to evaluate the irradiation embrittlement due to neutrons during operation and set the condition of safe operation of nuclear reactor. The 1st surveillance testing was performed completely by Korea Atomic Energy Research Institute at Taejon after the capsule was transported from Ulchin site including its removal from reactor. Fast neutron fluences for capsules were calculated and various testing including mechanical and chemistry analysis were performed in order to evaluate the integrity of Ulchin unit 3 reactor vessel during the operation until life time. The evaluation results are as follows; Fast neutron fluences for capsule 2 is 4.674E 18n/cm{sup 2}. The bias factor, the ratio of calculation/measurement, was 0.920 for the 1st testing and the calculational uncertainty,7.0% satisfied the requirement of USNRC Reg.Guide 1.190, 20%. The best estimated neutron fluence for reactor vessel inside surface was 3.913E 18n/cm{sup 2} based on the end of 6th fuel cycle and it was predicted that the fluences of vessel inside surface at 16 and 32EFPY would reach 9.249E 18 and 1.834E 19n/cm{sup 2} based on the current calculation. The result through this analysis for Ulchin unit 3 showed that there would be no problem for the pressurized thermal shock(PTS) during the operation until design life.

  2. Final Report for the 1st Surveillance Test of the Reactor Pressure Vessel Material (Capsule 2) of Ulchin Nuclear Power Plant Unit 4

    Chang, Kee Ok; Kim, Byoung Chul; Lee, Sam Lai (and others)

    2007-04-15

    Surveillance testing for reactor vessel materials is performed in order to evaluate the irradiation embrittlement due to neutrons during operation and set the condition of safe operation of nuclear reactor. The 1st surveillance testing was performed completely by Korea Atomic Energy Research Institute at Daejon after the capsule was transported from Ulchin site including its removal from reactor. Fast neutron fluences for capsules were calculated and various testing including mechanical and chemistry analysis were performed in order to evaluate the integrity of Ulchin Unit 4 reactor vessel during the operation until life time. The evaluation results are as follows; Fast neutron fluences for capsule 2 is 4.306E+18n/cm{sup 2}. The bias factor, the ratio of calculation/measurement, was 0.918 for the 1st testing and the calculational uncertainty,7.0% satisfied the requirement of USNRC Reg.Guide 1.190, 20%. The best estimated neutron fluence for reactor vessel inside surface was 3.615E+18n/cm{sup 2} based on the end of 6th fuel cycle and it was predicted that the fluences of vessel inside surface at 16 and 32EFPY would reach 8.478E+18 and 1.673E+19n/cm{sup 2} based on the current calculation. The result through this analysis for Ulchin Unit 4 showed that there would be no problem for the pressurized thermal shock(PTS) during the operation until design life.

  3. The 1st Irradiation Test Results of the High Burn-up Large Grain UO{sub 2} Pellets in HANARO

    Kim, Dae Ho; Bang, Jae Geun; Yang, Yong Sik; Song, Keun Woo; Kim, Sun Kee; Kim, Young Min; Seo, Chul Gyo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2005-07-01

    The large grain UO{sub 2} pellet developed for the high burn-up PWR fuel was finished the 1st irradiation test in the HANARO since July of 2002. The large grain UO{sub 2} pellets will be irradiated up to the burn-up higher than 70 MWD/kgU. To irradiate the UO{sub 2} pellets up to the burn-up 70 MWD/kgU, it will take about 60 months. Now the 1st irradiation test for about 30 months was finished. The burn-up of the fuel rods was 33.62 MWD/kgU for the upper three fuel rods and 37.39 MWD/kgU for the lower three fuel rods, as of the June of 2005 by which the effective irradiation time is 320.6 day at the OR-4 of HANARO. These test rods were burned the lower about 9 % against target burn-up because the control rod of HANARO was operated at the lower position than analysis condition. The lower test rod assembly is loading into the new non-instrument capsule for the 2nd irradiation test and the 2nd irradiation test will be started in time.

  4. Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus.

    de Carvalho, Camila Rodrigues; Vieira, Mariana de Lourdes Almeida; Cantrell, Charles L; Wedge, David E; Alves, Tânia M A; Zani, Carlos Leomar; Pimenta, Raphael Sanzio; Sales Junior, Policarpo A; Murta, Silvane M F; Romanha, Alvaro J; Rosa, Carlos Augusto; Rosa, Luiz H

    2016-01-01

    Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asteraceae), and identified using molecular, physiological and morphological methods. A methylene chloride crude extract of A. calidoustus has been produced and subjected to antifungal bioassay-directed fractionation which resulted in the isolation of the two bioactive compounds: ophiobolin K and 6-epi-ophiobolin K. These pure compounds displayed antifungal activity against fungal plant pathogens, protozoal activity against Trypanosoma cruzi, and cytotoxic activity against human tumoral cell lines. The results show that A. calidoustus was able to produce the antifungal and cytotoxic metabolites ophiobolin K and 6-epi-ophiobolin K, which may help the fungus to colonise and occupy the substratum as well as survive in natural environments. PMID:25812930

  5. Comparison of web-based biosecurity intelligence systems: BioCaster, EpiSPIDER and HealthMap.

    Lyon, A; Nunn, M; Grossel, G; Burgman, M

    2012-06-01

    Three web-based biosecurity intelligence systems - BioCaster, EpiSPIDER and HealthMap--are compared with respect to their ability to gather and analyse information relevant to public health. Reports from each system for the period 2-30 August 2010 were studied. The systems were compared to the volume of information that they acquired, their overlaps in this information, their timeliness, their sources, their focus on different languages and their focus on different geographical regions. Main results were as follows: EpiSPIDER obtains the most information and does so mainly through Twitter; no significant difference in systems' timeliness was found; there is a relatively small overlap between the systems (10-20%); the systems have significant differences in their ability to acquire information relevant to different countries, which may be due to the sources they use and the languages they focus on. PMID:22182229

  6. Characterization of ancient Japanese glass excavated from archaeological sites of the Epi-Jomon period in Hokkaido by XRF analysis

    Ancient glass beads from the Epi-Jomon period, excavated from 7 archaeological sites in Hokkaido, were non-destructively analyzed by using a portable XRF spectrometer. The origin and distribution of the glass beads were analyzed based on their quantitative chemical compositions. The chemical compositions of glass beads from Hokkaido can be classified into two glass types based on their major components: i.e., potash silica glass type (K2O–SiO2) and soda lime silica glass (Na2O–CaO–SiO2). The heavy trace element compositions of glass beads excavated from Hokkaido were basically similar to those excavated from the Kyushu region, Kanto region and Southeast Asia, as reported in our previous studies. From these results it has been found for the first time that glass beads exist with the same origin as those from Honshu distributed in Hokkaido in Epi-Jomon period. (author)

  7. Considerations in high resolution skeletal muscle DTI using single-shot EPI with stimulated echo preparation and SENSE

    Karampinos, Dimitrios C.; Banerjee, Suchandrima; King, Kevin F.; Link, Thomas M.; Majumdar, Sharmila

    2011-01-01

    Previous studies have shown that skeletal muscle diffusion tensor imaging (DTI) can non-invasively probe changes in the muscle fiber architecture and microstructure in diseased and damaged muscles. However, DTI fiber reconstruction in small muscles and in muscle regions close to aponeuroses and tendons remains challenging because of partial volume effects. Increasing the spatial resolution of skeletal muscle single-shot diffusion weighted (DW)-EPI can be hindered by the inherently low SNR of ...

  8. NCI Researchers Discover Exceptionally Potent Antibodies with Potential for Prophylaxis and Therapy of MERS-Coronavirus Infections | Poster

    By Andrea Frydl, Contributing Writer In a recent article published in the Journal of Virology, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Laboratory of Experimental Immunology (LEI), Cancer and Inflammation Program, NCI Center for Cancer Research, reported the identification of three human monoclonal antibodies (m336, m337, and m338) that target the part of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) that is responsible for binding to its receptor. These antibodies are exceptionally potent inhibitors of MERS-CoV infection and also provide a basis for creating a future MERS-CoV vaccine.

  9. NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

    William C Reinhold

    Full Text Available Exome sequencing provides unprecedented insights into cancer biology and pharmacological response. Here we assess these two parameters for the NCI-60, which is among the richest genomic and pharmacological publicly available cancer cell line databases. Homozygous genetic variants that putatively affect protein function were identified in 1,199 genes (approximately 6% of all genes. Variants that are either enriched or depleted compared to non-cancerous genomes, and thus may be influential in cancer progression and differential drug response were identified for 2,546 genes. Potential gene knockouts are made available. Assessment of cell line response to 19,940 compounds, including 110 FDA-approved drugs, reveals ≈80-fold range in resistance versus sensitivity response across cell lines. 103,422 gene variants were significantly correlated with at least one compound (at p<0.0002. These include genes of known pharmacological importance such as IGF1R, BRAF, RAD52, MTOR, STAT2 and TSC2 as well as a large number of candidate genes such as NOM1, TLL2, and XDH. We introduce two new web-based CellMiner applications that enable exploration of variant-to-compound relationships for a broad range of researchers, especially those without bioinformatics support. The first tool, "Genetic variant versus drug visualization", provides a visualization of significant correlations between drug activity-gene variant combinations. Examples are given for the known vemurafenib-BRAF, and novel ifosfamide-RAD52 pairings. The second, "Genetic variant summation" allows an assessment of cumulative genetic variations for up to 150 combined genes together; and is designed to identify the variant burden for molecular pathways or functional grouping of genes. An example of its use is provided for the EGFR-ERBB2 pathway gene variant data and the identification of correlated EGFR, ERBB2, MTOR, BRAF, MEK and ERK inhibitors. The new tools are implemented as an updated web-based Cell

  10. Keratectomy errors and changes in corneal topography after LASIK and Epi-LASIK surgeries%LASIK和Epi-LASIK术中角膜切削误差及术后角膜地形图变化比较

    赵瑞博; 郭永红; 张凌子

    2016-01-01

    目的 探讨准分子激光原位角膜磨镶术(LASIK)和准分子激光上皮下角膜磨镶术(Epi-LASIK)术中角膜切削误差及术后角膜地形图变化.方法 选取2012年2月至2014年8月我院行近视激光矫正手术患者211例(403只眼)作为研究对象,随机分为LASIK组和Epi-LASIK组,其中LASIK组110例(209只眼),Epi-LASIK组为101例(194只眼),分别采取相应手术,观察术后两组患者角膜切削误差及术前与术后1、3个月两组高度近视患者角膜地形图形态Simk差值、Simk等效值、CIM值及SF绝对值4个参数变化.结果 两组中轻中度近视患者角膜切削误差无显著差异(P>0.05),Epi-LASIK组中高度近视患者的角膜切削误差显著小于LASIK组(P<0.05);两组高度近视患者术前角膜图形均以对称领结型及非对称领结型为主,两组各形态间无显著差异(P>0.05);两组高度近视患者术后角膜地形图形均以平滑型为主,LASIK组的平滑型显著低于Epi-LASIK组(P<0.05),其余形态两组比较无显著差异(P>0.05);在Simk差值、Simk等效值上,两组术后结果均显著低于术前(P<0.05),两组间术后结果对比无显著差异(P>0.05);在CIM值上,两组术后结果均显著高于术前(P<0.05),LASIK组术后结果均显著高于Epi-LASIK组(P<0.05);在SF绝对值上,两组术后结果均显著低于术前(P<0.05),两组间术后结果对比无显著差异(P>0.05).结论 Epi-LASIK可有效降低术中角膜切削误差及改善术后角膜地形图参数,有利于增强手术的效果,促进术后患者的恢复及改善患者预后,可在临床检查中广泛推广.

  11. A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

    Brancaleone, Vincenzo; Gobbetti, Thomas; Cenac, Nicolas; Le Faouder, Pauline; Colom, Bartomeu; Flower, Roderick J.; Vergnolle, Nathalie; Nourshargh, Sussan; Perretti, Mauro

    2013-01-01

    Fpr2/3 activation controls platelet/neutrophil aggregates to afford LXA4 synthesis, thus inhibiting vascular inflammation on reperfusion.Aspirin can jumpstart this circuit by triggering 15-epi-lipoxin synthesis.

  12. EGF–FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)

    Epidermal neural crest stem cells (EPI-NCSCs), which reside in the bulge of hair follicles, are attractive candidates for several applications in cell therapy, drug screening and tissue engineering. As suggested remnants of the embryonic neural crest (NC) in an adult location, EPI-NCSCs are able to generate a wide variety of cell types and are readily accessible by a minimally invasive procedure. Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF2) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the proliferation and neuronal potential of mouse EPI-NCSCs. By using a recognized culture protocol of bulge whiskers follicles, we were able to isolate a population of EPI-NCSCs, characterized by the migratory potential, cell morphology and expression of phenotypic markers of NC cells. EPI-NCSCs expressed neuronal, glial and smooth muscle markers and exhibited the NC-like fibroblastic morphology. The treatment with the combination EGF and FGF2, however, increased their proliferation rate and promoted the acquisition of a neuronal-like morphology accompanied by reorganization of neural cytoskeletal proteins βIII-tubulin and nestin, as well as upregulation of the pan neuronal marker βIII-tubulin and down regulation of the undifferentiated NC, glial and smooth muscle cell markers. Moreover, the treatment enhanced the response of EPI-NCSCs to neurogenic stimulation, as evidenced by induction of GAP43, and increased expression of Mash-1 in neuron-like cell, both neuronal-specific proteins. Together, the results suggest that the combination of EGF–FGF2 stimulates the proliferation and improves the neuronal potential of EPI-NCSCs similarly to embryonic NC cells, ES cells and neural progenitor/stem cells of the central nervous system and highlights the advantage of using EGF–FGF2 in neuronal differentiation protocols. - Highlights: • EPI-NCSCs express

  13. EGF–FGF{sub 2} stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)

    Bressan, Raul Bardini; Melo, Fernanda Rosene; Almeida, Patricia Alves; Bittencourt, Denise Avani; Visoni, Silvia; Jeremias, Talita Silva [Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil); Costa, Ana Paula; Leal, Rodrigo Bainy [Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil); Trentin, Andrea Gonçalves, E-mail: andrea.trentin@ufsc.br [Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil)

    2014-09-10

    Epidermal neural crest stem cells (EPI-NCSCs), which reside in the bulge of hair follicles, are attractive candidates for several applications in cell therapy, drug screening and tissue engineering. As suggested remnants of the embryonic neural crest (NC) in an adult location, EPI-NCSCs are able to generate a wide variety of cell types and are readily accessible by a minimally invasive procedure. Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF{sub 2}) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the proliferation and neuronal potential of mouse EPI-NCSCs. By using a recognized culture protocol of bulge whiskers follicles, we were able to isolate a population of EPI-NCSCs, characterized by the migratory potential, cell morphology and expression of phenotypic markers of NC cells. EPI-NCSCs expressed neuronal, glial and smooth muscle markers and exhibited the NC-like fibroblastic morphology. The treatment with the combination EGF and FGF{sub 2}, however, increased their proliferation rate and promoted the acquisition of a neuronal-like morphology accompanied by reorganization of neural cytoskeletal proteins βIII-tubulin and nestin, as well as upregulation of the pan neuronal marker βIII-tubulin and down regulation of the undifferentiated NC, glial and smooth muscle cell markers. Moreover, the treatment enhanced the response of EPI-NCSCs to neurogenic stimulation, as evidenced by induction of GAP43, and increased expression of Mash-1 in neuron-like cell, both neuronal-specific proteins. Together, the results suggest that the combination of EGF–FGF2 stimulates the proliferation and improves the neuronal potential of EPI-NCSCs similarly to embryonic NC cells, ES cells and neural progenitor/stem cells of the central nervous system and highlights the advantage of using EGF–FGF{sub 2} in neuronal differentiation protocols. - Highlights: • EPI

  14. Clinical observation of haze after epipolis laser in situ keratomileusis%Epi-LASIK术后Haze形成的临床观察

    张亚丽; 左天南; 刘蕾; 胡明; 李招娜

    2009-01-01

    央厚度上无统计学差异.结论 EpiLASIK术后Haze发生率及密度均较低,术后是否发生Haze与屈光度数,切削深度和切削率有关.%ncidence and density of Haze in Epi-LASIK.Higher myopia,deeper ablation and higher ablation depth/corneal thickness ratio obviously influenee the Haze formation.

  15. Bringing evidence to policy to achieve health-related MDGs for all : justification and design of the EPI-4 project in China, India, Indonesia, and Vietnam

    Thomsen, Sarah; Ng, Nawi; Biao, Xu; Bondjers, Göran; Kusnanto, Hari; Liem, Nguyen Tanh; Mavalankar, Dileep; Målqvist, Mats; Diwan, Vinod

    2013-01-01

    Background: The Millennium Development Goals (MDGs) are monitored using national-level statistics, which have shown substantial improvements in many countries. These statistics may be misleading, however, and may divert resources from disadvantaged populations within the same countries that are showing progress. The purpose of this article is to set out the relevance and design of the ‘‘Evidence for Policy and Implementation project (EPI-4)’’. EPI-4 aims to contribute to the reduction of ineq...

  16. The reconstructed skin micronucleus assay in EpiDerm™: reduction of false-positive results - a mechanistic study with epigallocatechin gallate.

    Yuki, Katsuyuki; Ikeda, Naohiro; Nishiyama, Naohiro; Kasamatsu, Toshio

    2013-10-01

    The high rate of false-positive or misleading results in in vitro mammalian genotoxicity testing is a hurdle in the development of valuable chemicals, especially those used in cosmetics, for which in vivo testing is banned in the European Union. The reconstructed skin micronucleus (RSMN) assay in EpiDerm™ (MatTek Corporation, USA) has shown promise as a follow-up for positive in vitro mammalian genotoxicity tests. However, few studies have explored its better predictive performance compared with existing in vitro assays. In the present study, we followed the protocol of the RSMN assay and used eight chemicals to compare micronucleus (MN) induction with EpiDerm™ with that in normal human epidermal keratinocytes (NHEKs), both derived from human skin. The assessments of EpiDerm™ conformed to those of in vivo MN assay, whereas those of NHEKs did not. The effect of cell differentiation status on MN induction was further addressed using a model compound, epigallocatechin gallate (EGCG), which is a major component of green tea extract that shows positive results in in vitro mammalian genotoxicity assays via oxidative stress and negative results in in vivo MN studies. RSMN assay in an underdeveloped epidermal model, EpiDerm-201™ (MatTek Corporation), showed a negative result identical to that in EpiDerm™, indicating that the barrier function of keratinocytes has limited impact. Analysis of the gene expression profile of both EpiDerm™ and NHEKs after EGCG treatment for 12h revealed that the expression of genes related to genotoxic response was significantly induced only in NHEKs. Conversely, antioxidative enzyme activities (catalase and glutathione peroxidase) in EpiDerm™ were higher than those in NHEKs. These results indicate that EpiDerm™ has antioxidant properties similar to those of a living body and is capable of eliminating oxidative stress that may be caused by EGCG under in vitro experimental conditions. PMID:23988588

  17. Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe An EpiCom study

    Burisch, Johan Michael; Cukovic-Cavka, Silvija; Kaimakliotis, Ioannis;

    2011-01-01

    The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration.......The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration....

  18. EpiCollect+: linking smartphones to web applications for complex data collection projects [v1; ref status: indexed, http://f1000r.es/3vk

    David M. Aanensen

    2014-08-01

    Full Text Available Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry, whereas many applications require a more complex structure, allowing users to link a series of forms in a linear or branching hierarchy, along with the addition of any number of media types accessible from smartphones and/or tablet devices (e.g., GPS, photos, videos, sound clips and barcode scanning. A much enhanced version of EpiCollect has been developed (EpiCollect+. The individual data collection forms in EpiCollect+ provide more design complexity than the single form used in EpiCollect, and the software allows the generation of complex data collection projects through the ability to link many forms together in a linear (or branching hierarchy. Furthermore, EpiCollect+ allows the collection of multiple media types as well as standard text fields, increased data validation and form logic. The entire process of setting up a complex mobile phone data collection project to the specification of a user (project and form definitions can be undertaken at the EpiCollect+ website using a simple ‘drag and drop’ procedure, with visualisation of the data gathered using Google Maps and charts at the project website. EpiCollect+ is suitable for situations where multiple users transmit complex data by mobile phone (or other Android devices to a single project web database and is already being used for a range of field projects, particularly public health projects in sub-Saharan Africa. However, many uses can be envisaged from education, ecology and epidemiology to citizen science.

  19. Fabrication of a compact 1st-order SQUID gradiometer system to measure fMCG signals in a moderate MSR

    We fabricated a low-noise 64-channel axial-type 1st-order gradiometer system for measuring fetal magnetocardiography (fMCG) signals. A superconducting quantum interference device (SQUID) was based on a double relaxation oscillation SQUID (DROS) with a high flux-to-voltage transfer coefficient to simplify the flux-locked-loop (FLL) circuit. The pickup coil of the SQUID sensor was wound with 125 μm of NbTi wire on a bobbin (20 mm diameter) and had a 1st-order differential coil to reject the environment noise. The pickup coil was directly connected to a DROS by using a 25 μm superconductive wire and a ultra-wedge bonder. The direct connection between the DROS and the pickup coil improved the balance factor by more than 100 times. The superconductive wire was annealed at 2400 .deg. C in a vacuum chamber to improve the wire's ductility. The 1st-order gradiometers had a long baseline of 70 mm to detect magnetic signals for the deep source. The structure of between gradiometers is a tri-angle arrangement to minimize the signal loss. Also, the hexagonal structure of the MCG insert was used to cover the maximum area of the subject. The average white noise for all channels of the MCG system was about 3.5 fT/Hz1/2 at 100 Hz. The fetal MCG was measured for a fetus at 20 ∼ 36 weeks every two weeks in a moderate magnetically shielded room (MSR). The shielding factors of the fabricated MSR with a thin wall thickness of 10 cm were about 35 dB at 0.1Hz and 80 dB at 100Hz. We could measure the complex MCG signals, which were consisted of the maternal MCG, the fetal MCG and environment noise. The signal-to-noise ratio (SNR) of the fMCG was about 10. After averaging 20 times only, we could clearly observe the P, T-peak, as well as QRS complex wave. Thus, we expect the compact SQUID systems to be useful for detecting fetal cardiac diseases.

  20. Infrared spectra of brassinolide and castasterone steroid phytohormones and their 24-epi derivatives

    Borisevich, N. A.; Buslov, D. K.

    2010-09-01

    Absorption bands in IR spectra of brassinolide, castasterone, and their 24-epi derivatives in the frequency range 3800-1000 cm-1 have been interpreted. A number of spectral features distinguishing brassinolide from castasterone have been found. The conducted analysis shows that the structural differences manifest themselves in IR spectra of the investigated brassinosteroids in the region of stretching vibrations of CO-H, C=O, C-OH, C-O-C, CH3, CH2, and CH groups. The main distinctions in IR spectra of brassinolides and castasterones are due to the B ring structure. All hydroxyl groups of brassinosteroids pressed in KBr are included in hydrogen bonds. Broad bands attributed to associated OH groups are observed in the IR spectra. Two possible kinds of hydrogen bonding exist. IR spectra of diluted solutions of the studied brassinosteroids contain two bands caused by vibrations of free hydroxyls and those associated by intramolecular hydrogen bonds. A fraction of the C=O groups of brassinosteroids pressed in KBr remains free. High-frequency bands in solid-state IR spectra are due to vibrations of free C=O groups whereas low-frequency bands are attributed to stretching vibrations of associated groups. The lack of low-frequency bands in solution spectra proves that the C=OṡṡṡH-O hydrogen bond is intermolecular rather than intramolecular. Vibrational frequencies of brassinolide C=O groups are higher than the corresponding frequencies for castasterones because of the influence of oxygen in the seven-membered B ring.

  1. Les competències professionals de l'entrenador de tennis. La visió dels seus formadors a nivell internacional

    Campos Rius, Josep

    2015-01-01

    En l’esport s’estan incorporant els plantejaments de la formació en base a competències adreçada als tècnics esportius. Les competències professionals estan definint en els diferents àmbits el perfil dels entrenadors encarregats de la formació, entrenament i gestió de l’esport i, en el cas d’aquesta recerca, en el tennis. La Tesi Doctoral té la voluntat de detectar i analitzar quines són les competències professionals de l’entrenador de tennis en general, en funció del nivell d’entrenament...

  2. Effect of fractionated 60Co γ-ray irradiation on 8-epi-prostaglandin F2α in plasma and RBC membrane of dogs

    Objective: By observing the alteration of 8-epi-prostaglandin F2α(8-epi-PGF2α) in plasma and RBC membrane of dogs during and after γ irradiation, and comparing it with malondialdehyde (MDA), the authors aimed to assess the value of measuring its concentrations in realizing the irradiation-induced lipid peroxidative reaction, and to detect the effect of superoxide dismutase (SOD) on this procedure. Methods: 18 adult out bred dogs (6 dogs each were randomly assigned to low-dose SOD treatment group, high-dose SOD treatment group and control group) were irradiated with 60Co γ-rays at a dose of 0.6 Gy per day for 5 days, and the concentrations of 8-epi-PGF2α and MDA in plasma and RBC membrane were assayed before, during, and after the irradiation. Results: The mean plasma 8-epi-PGF2α level in dogs was significantly increased during the γ-irradiation, and gradually decreased after the irradiation was ended, while the enhanced 8-epi-PGF2α concentration in RBC membrane was higher than that in plasma, and it reached the peak level at the 2nd day after the irradiation was ended and then started to decrease; SOD could markedly inhibit its increase. The levels of MDA in plasma and RBC membrane were not significantly changed. Conclusion: 8-epi-PGF2α can serve as a new and more sensitive index for reflecting the irradiation-induced lipid peroxidative reaction

  3. Compressed Sensing for fMRI: Feasibility Study on the Acceleration of Non-EPI fMRI at 9.4T

    Paul Kyu Han

    2015-01-01

    Full Text Available Conventional functional magnetic resonance imaging (fMRI technique known as gradient-recalled echo (GRE echo-planar imaging (EPI is sensitive to image distortion and degradation caused by local magnetic field inhomogeneity at high magnetic fields. Non-EPI sequences such as spoiled gradient echo and balanced steady-state free precession (bSSFP have been proposed as an alternative high-resolution fMRI technique; however, the temporal resolution of these sequences is lower than the typically used GRE-EPI fMRI. One potential approach to improve the temporal resolution is to use compressed sensing (CS. In this study, we tested the feasibility of k-t FOCUSS—one of the high performance CS algorithms for dynamic MRI—for non-EPI fMRI at 9.4T using the model of rat somatosensory stimulation. To optimize the performance of CS reconstruction, different sampling patterns and k-t FOCUSS variations were investigated. Experimental results show that an optimized k-t FOCUSS algorithm with acceleration by a factor of 4 works well for non-EPI fMRI at high field under various statistical criteria, which confirms that a combination of CS and a non-EPI sequence may be a good solution for high-resolution fMRI at high fields.

  4. Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines.

    Barry R Zeeberg

    Full Text Available BACKGROUND: The NCI-60 is a panel of 60 diverse human cancer cell lines used by the U.S. National Cancer Institute to screen compounds for anticancer activity. In the current study, gene expression levels from five platforms were integrated to yield a single composite transcriptome profile. The comprehensive and reliable nature of that dataset allows us to study gene co-expression across cancer cell lines. METHODOLOGY/PRINCIPAL FINDINGS: Hierarchical clustering revealed numerous clusters of genes in which the genes co-vary across the NCI-60. To determine functional categorization associated with each cluster, we used the Gene Ontology (GO Consortium database and the GoMiner tool. GO maps genes to hierarchically-organized biological process categories. GoMiner can leverage GO to perform ontological analyses of gene expression studies, generating a list of significant functional categories. CONCLUSIONS/SIGNIFICANCE: GoMiner analysis revealed many clusters of coregulated genes that are associated with functional groupings of GO biological process categories. Notably, those categories arising from coherent co-expression groupings reflect cancer-related themes such as adhesion, cell migration, RNA splicing, immune response and signal transduction. Thus, these clusters demonstrate transcriptional coregulation of functionally-related genes.

  5. Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program

    Fennell Mary L

    2009-09-01

    Full Text Available Abstract Background In this article, we describe the National Cancer Institute (NCI Community Cancer Centers Program (NCCCP pilot and the evaluation designed to assess its role, function, and relevance to the NCI's research mission. In doing so, we describe the evolution of and rationale for the NCCCP concept, participating sites' characteristics, its multi-faceted aims to enhance clinical research and quality of care in community settings, and the role of strategic partnerships, both within and outside of the NCCCP network, in achieving program objectives. Discussion The evaluation of the NCCCP is conceptualized as a mixed method multi-layered assessment of organizational innovation and performance which includes mapping the evolution of site development as a means of understanding the inter- and intra-organizational change in the pilot, and the application of specific evaluation metrics for assessing the implementation, operations, and performance of the NCCCP pilot. The assessment of the cost of the pilot as an additional means of informing the longer-term feasibility and sustainability of the program is also discussed. Summary The NCCCP is a major systems-level set of organizational innovations to enhance clinical research and care delivery in diverse communities across the United States. Assessment of the extent to which the program achieves its aims will depend on a full understanding of how individual, organizational, and environmental factors align (or fail to align to achieve these improvements, and at what cost.

  6. Comparison of the ISU, NCI, MSM, and SPADE Methods for Estimating Usual Intake: A Simulation Study of Nutrients Consumed Daily

    Greice H. C. Laureano

    2016-03-01

    Full Text Available Various methods are available for estimating usual dietary intake distributions. Hence, there is a need for simulation studies to compare them. The methods Iowa State University (ISU, National Cancer Institute (NCI, Multiple Source Method (MSM and Statistical Program to Assess Dietary Exposure (SPADE were previously compared in another study, but some results were inconclusive due to the small number of replications used in the simulation. Seeking to overcome this limitation, the present study used 1000 simulated samples for 12 different scenarios to compare the accuracy of estimates yielded by the aforementioned methods. The focus is on scenarios that exhibited the most uncertainty in the conclusions of the mentioned study above, i.e., scenarios with small sample sizes, skewed intake distributions, and large ratios of the between- and within-person variances. Bias was used as a measure of accuracy. For scenarios with small sample sizes (n = 150, the ISU, MSM and SPADE methods generally achieved more accurate estimates than the NCI method, particularly for the 10th and 90th percentiles. The differences between methods became smaller with larger sample sizes (n = 300 and n = 500. With few exceptions, the methods were found to perform similarly.

  7. Clinical evaluation of echo-planar diffusion-weighted imaging (EPI-DWI) for diagnosis of breast cancer

    The purpose of this study was to compare echo-planar diffusion-weighted imaging (EPI-DWI) with dynamic contrast-enhanced magnetic resonance imaging (MRI) in terms of the rate of detection, extension, and quality of diagnosis of breast cancer in order to estimate the usefulness of EPI-DWI. One hundred and three cases of 101 patients who underwent MRI prior to surgery for breast cancer were evaluated. (papillotubular carcinoma 22; solid-tubular carcinoma 20; scirrhous carcinoma 45; mucinous carcinoma 2; medullary carcinoma 1; invasive lobular carcinoma 2; apocrine carcinoma 2; ductal carcinoma in situ (DCIS) and microinvasive ductal carcinoma 9). Twelve cases of benign lesion were also evaluated. Single-shot EPI-DWI was performed before routine dynamic MRI and images of cancer detection and cancer extension both were compared with the pathological findings. The apparent diffusion coefficient (ADC) values of the lesions were measured and compared to the ADC values of benign lesions and normal breast tissues. The differences between the ADC values for the various histopathological types and the time-intensity curve (TIC) patterns of the dynamic MRI were also estimated. The EPI-DWI demonstrated abnormal high-intensity areas corresponding to the breast cancer lesions; these areas demonstrated good correlation with the enhanced areas observed in the early phase of dynamic MRI and cancer extension in the pathological findings. Frequently, normal breast tissues manifested as high-intensity areas in EPI-DWI; however, it was possible to distinguish between normal breast tissues and breast lesions by correlating these images with T2- weighted images and corresponding ADC values. The threshold value between malignant and benign lesions that resulted both high sensitivity and specificity was about 1.5 x 10-3 x mm2/second. Mucinous carcinoma and DCIS/ microinvasive carcinoma exhibited higher ADC values than those observed in the other histopathological types, however, no

  8. An anthraquinone derivative from Luffa acutangula induces apoptosis in human lung cancer cell line NCI-H460 through p53-dependent pathway.

    Vanajothi, Ramar; Srinivasan, Pappu

    2016-06-01

    The current study was designed to evaluate the in vitro antiproliferative activity of 1,8-dihydroxy-4-methylanthracene-9,10-dione (DHMA) isolated from the Luffa acutangula against human non-small cell lung cancer cell line (NCI-H460). Induction of apoptosis and reactive oxygen species (ROS) generation was determined through fluorescence microscopic technique. Quantitative real-time PCR and western blotting analysis was carried out to detect the expression of pro-apoptotic (p53, p21, caspase-3, Bax, GADD45A, and ATM) and anti-apoptotic (NF-κB) proteins in NCI-H460 cell line. In silico studies also performed to predict the binding mechanism of DHMA with MDM2-p53 protein. The DHMA inhibited the cell viability of NCI-H460 cells in a dose-dependent manner with an IC50 of about 50 µg/ml. It significantly reduced cell viability correlated with induction of apoptosis, which was associated with ROS generation. The apoptotic cell death was further confirmed through dual staining and DNA fragmentation assay. DHMA significantly increased the expression of anti-apoptotic protein such as p53, p21, Bax, and caspase-3 but downregulated the expression of NF-κB in NCI-H460 cell line. In silico studies demonstrate that DHMA formed hydrogen bond interaction with key residues Trp26, Phe55 and Lys24 by which it disrupt the binding of p53 with MDM2 receptor. These findings suggested that DHMA induces apoptosis in NCI-H460 via a p53-dependent pathway. This the first study on cytotoxic and apoptosis inducing activity of DHMA from L. acutangula against NCI-H460 cell line. Therefore, DHMA has therapeutic potential for lung cancer treatment. PMID:26585176

  9. JANNAF 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee Joint Meeting. Volume 1

    Fry, Ronald S.; Becker, Dorothy L.

    2000-01-01

    Volume I, the first of three volumes, is a compilation of 24 unclassified/unlimited-distribution technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee (MSS) meeting held jointly with the 19th Propulsion Systems Hazards Subcommittee. The meeting was held 13-17 November 2000 at the Naval Postgraduate School and Hyatt Regency Hotel, Monterey, California. Topics covered include: a Keynote Address on Future Combat Systems, a review of the new JANNAF Modeling and Simulation Subcommittee, and technical papers on Hyper-X propulsion development and verification; GTX airbreathing launch vehicles; Hypersonic technology development, including program overviews, fuels for advanced propulsion, ramjet and scramjet research, hypersonic test medium effects; and RBCC engine design and performance, and PDE and UCAV advanced and combined cycle engine technologies.

  10. Understanding Stress-Related Behavioral Phenotypes: Report from the 1st International Neuroscience Summer School and the 11th International “Stress and Behavior” Conference

    J. L. LaPorte

    2008-01-01

    Full Text Available The 1st International Neuroscience Summer School and the 11th International Multidisciplinary Neuroscience and Biopsychiatry Conference on Stress and Behavior were held in St. Petersburg, Russia, during May 9–20, 2008. The summer school gathered 30 talented young scientists from 15 countries worldwide, and was dedicated to different topics of behavioral neuroscience. Many interactive courses were provided on neuropharmacology, animal phenotyping, and biopsychology. The conference's excellent scientific and social program attracted almost 500 delegates from 40 countries from many areas of stress research. The eclectic interaction between medical doctors, basic scientists, psychologists, and students made for a productive and collaborative environment, which contributed greatly to the success of the school and conference.

  11. Spatial epidemiology in zoonotic parasitic diseases: insights gained at the 1st International Symposium on Geospatial Health in Lijiang, China, 2007

    Bergquist N Robert

    2009-02-01

    Full Text Available Abstract The 1st International Symposium on Geospatial Health was convened in Lijiang, Yunnan province, People's Republic of China from 8 to 9 September, 2007. The objective was to review progress made with the application of spatial techniques on zoonotic parasitic diseases, particularly in Southeast Asia. The symposium featured 71 presentations covering soil-transmitted and water-borne helminth infections, as well as arthropod-borne diseases such as leishmaniasis, malaria and lymphatic filariasis. The work made public at this occasion is briefly summarized here to highlight the advances made and to put forth research priorities in this area. Approaches such as geographical information systems (GIS, global positioning systems (GPS and remote sensing (RS, including spatial statistics, web-based GIS and map visualization of field investigations, figured prominently in the presentation.

  12. Comparative analysis of effectiveness of treatment with anti-TB drugs of the 1st and 2nd lines for children and adolescents with multidrug resistant tuberculosis

    Tleukhan Abildaev

    2012-05-01

    Full Text Available The paper shows results of study on comparative treatment effectiveness in children and adolescents with from multi drug resistant tuberculosis MDR TB (2000-2008 treated with anti-TB drugs of the 2nd line (80 patients and 1st line (80 patients in the Kazakhstan. It was stated in patients with MDR TB that outcomes of treatment were successful in 91.2%, but relapse development of TB disease occurred in 12.7% of cases, and 5 (6.2% patients died (P ≤0.05. Thus, patients with MDR TB need to be treated with anti-TB drugs of the 2nd line accordingly to their DST.

  13. Seismic electric precursors observed prior to the 6.3R EQ of July 1st 2009, Greece and their use in short-term earthquake prediction

    Thanassoulas, C; Verveniotis, G; Zymaris, N

    2009-01-01

    The normalized raw data of the Earth's electric field, monitored at PYR, ATH, HIO monitoring sites in Greece, are studied as far as it concerns the presence of electric seismic precursors. Electric preseismic pulses, plateau-like anomalous electric field and Very Long Period (VLP) anomalies were detected prior to the occurrence of the July 1st, 2009 large (Ms = 6.3R) EQ in Greece. Further processing of the same data revealed the true form of the generated preseimic potential thus providing an indirect estimation of the time window of the occurrence of the large EQ. Finally, by correlating, at pairs, the anomalous electric field from all monitoring sites it is possible to calculate the "strange attractor like" seismic electric precursor that provides a time window for the occurrence of the large EQ and utilizes the determination not only of the regional seismogenic area that has been activated but also a more precise epicenter too.

  14. Competències professionals en Educació per a la Sostenibilitat des de la Complexitat: plantejament i instrument d’avaluació

    García Segura, Mª Rosa

    2016-01-01

    La tesi doctoral Competències professionals en Educació per a la Sostenibilitat des de la complexitat: plantejament i instrument d’avaluació té per finalitat analitzar la mobilització de competències professionals en Educació per a la Sostenibilitat (ES) dels docents del Camp d’Aprenentatge Monestirs del Cister (CdAMC). Aquesta anàlisi pretén fer una contribució a l’enfocament competencial en ES i a la seva avaluació, des de la visió de la complexitat. Amb aquest propòsit es defineixen tre...

  15. 小细胞肺癌细胞系NCI-H446蛋白质表达谱的建立%Establishment of Protein Profile of Human Small Cell Lung Cancer Cell Line NCI-H446

    李茂玉; 肖志强; 李萃; 吴晓英; 冯雪萍; 易红; 李建玲; 陈主初; 陈平; 梁宋平

    2004-01-01

    背景与目的:小细胞肺癌(small cell lung cancer,SCLC)是一种侵袭性极强的恶性肿瘤,具有增长迅速、早期转移等特点.目前公开的数据库中尚未见到小细胞肺癌的双向电泳参考图谱及其蛋白表达谱.本研究目的是建立高分辨率的小细胞肺癌细胞系NCI-H446细胞双向凝胶电泳图谱,并初步分析其蛋白质表达情况.方法:用固相pH梯度双向凝胶电泳技术(IPG-DALT)分离NCI-H446细胞总蛋白,凝胶银染显色,ImageMaster 2D图像分析系统分析,从凝胶中选取分离较好的蛋白质点,应用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)技术和数据库搜索鉴定蛋白质.结果:获得了背景清晰、分辨率和重复性较好的双向凝胶电泳图谱,三块胶平均蛋白质点数为1 506±74,匹配点数为1 412±56,匹配率达93.4%,三块胶蛋白质点在位置上有较好的重复性,不同胶间蛋白质点在IEF方向偏差是(0.96±0.27)mm,在SDS-PAGE方向偏差是(1.24±0.41)mm.胶内酶解-肽质指纹图分析鉴定了58个蛋白质,其中有原癌蛋白、细胞周期调控和信号转导相关蛋白质.结论:建立了小细胞肺癌细胞系NCI-H446双向电泳参考图谱,并应用质谱技术鉴定了部分蛋白质点,为进一步构建其蛋白质表达数据库提供了基础.

  16. NGF 对 LASIK 及 Epi- LASIK术后角膜中 TrkA受体表达作用的研究

    余洁; 赵海岚; 吴苗琴

    2013-01-01

    Objective To investigate the effect of nerve growth factor (NGF) on the expression of TrkA in cornea after LASIK or Epi- LASIK. Methods Sixty eyes of 30 New Zealand white rabbits underwent LASIK or Epi- LASIK procedures with 30 eyes in each group. One eye, randomly selected in each rabbit was treated with topical NGF for 1 week, while the contralateral eye was treated with normal saline as control. The expression of NGF receptor (TrkA) on cornea was detected by histoimmuno-chemistry. Results The expression of TrkA on the cornea treated with the topical NGF after LASIK or Epi- LASIK was stronger than that of control group. There was no difference in expression of TrkA between LASIK and Epi- LASIK groups. Conclusion Topical treatment of NGF can up- regulate the expression of TrkA in the cornea of rabbits after LASIK or Epi- LASIK.%目的观察兔眼准分子激光原位角膜磨镶术(LASIK)及准分子激光上皮瓣下角膜磨镶术(Epi- LASIK)术后局部点用神经生长因子(NGF)后角膜组织中酪氨酸激酶受体A(TrkA)的表达情况,探索术后干眼症的防治方法。方法将30只新西兰纯种兔,抽取15只30眼接受LASIK手术,余接受Epi- LASIK手术。术后每只兔子一眼滴NGF滴眼液,为实验眼,对侧眼滴0.9%氯化钠溶液,为对照眼。1周后进行免疫组化分析,检测角膜上皮细胞层以及角膜基质层中TrkA的表达情况。结果观察TrKA的表达,接受LASIK或Epi- LASIK手术后,滴用NGF滴眼液的眼均较对照眼强。LASIK组以及Epi- LASIK组滴用NGF眼两者比较TrkA的表达无统计学差异。结论滴用NGF的兔眼,其LASIK或Epi- LASIK术后TrkA受体表达均较高,可能有助于防治近视激光术后干眼症。

  17. Comparison of long-axis and short-axis PROPELLER-EPI for diffusion-weighted magnetic resonance imaging; Vergleich von Long-Axis- und Short-Axis-PROPELLER-EPI fuer die diffusionsgewichtete Magnetresonanztomographie

    Rossbach, Matthias; Jochimsen, Thies H.; Herrmann, Karl-Heinz; Ros, Christian; Guellmar, Daniel; Reichenbach, Juergen R. [Jena Univ. Hospital (Germany). Medical Physics Group

    2011-07-01

    Echo planar imaging (EPI) in combination with PROPELLER allows high-resolution diffusion-weighted imaging. In this study, the image quality of short-axis and long-axis PROPELLER was compared and optimized using phantom and in vivo data. Furthermore, diffusion-weighted measurements using both sequences were compared with those of a reference sequence. It was found that the long-axis sequence provided better image quality, whereas the results of the diffusion weighted measurements were more accurate with the short-axis variant, and that the results of the diffusion weighted measurements of both sequences agreed well with those of the reference sequence. (orig.)

  18. Fatores associados aos sintomas depressivos em idosos: estudo EpiFloripa

    Lucelia Justino Borges

    2013-08-01

    Full Text Available OBJETIVO Analisar a prevalência e fatores associados a sintomas depressivos em idosos. MÉTODOS Estudo epidemiológico transversal e de base domiciliar (inquérito EpiFloripa Idoso com 1.656 idosos, realizado por conglomerados em dois estágios, setores censitários e domicílios, em Florianópolis, SC. A prevalência de sintomas depressivos (desfecho foi obtida por meio da Geriatric Depression Scale (GDS-15, e testadas associações segundo variáveis sociodemográficas, de saúde, comportamentais e sociais. Foram calculadas razões de prevalências brutas e ajustadas com intervalo de 95% de confiança por regressão de Poisson. RESULTADOS A prevalência de sintomas depressivos foi de 23,9% (IC95% 21,84;26,01. Os fatores de risco associados no modelo final foram: escolaridade de cinco a oito anos (RP = 1,50; IC95% 1,08; 2,08, um a quatro anos (RP = 1,62; IC95% 1,18; 2,23 e nenhum ano de estudo (RP = 2,11; IC95% 1,46;3,05; situação econômica pior quando comparada com a que tinha aos 50 anos (RP = 1,33; IC95% 1,02;1,74; déficit cognitivo (RP = 1,45; IC95% 1,21;1,75; percepção de saúde regular (RP = 1,95; IC95% 1,47;2,60 e ruim (RP = 2,64; IC95% 1,82;3,83; dependência funcional (RP = 1,83; IC95% 1,43; 2,33; e dor crônica (RP = 1,35; IC95% 1,10;1,67. Grupo etário de 70 a 79 anos (RP = 0,77; IC95% 0,64;0,93; atividade física de lazer (RP = 0,75; IC95% 0,59;0,94; participação em grupos de convivência ou religiosos (RP = 0,80; IC95% 0,64;0,99; e ter relação sexual (RP = 0,70; IC95% 0,53;0,94 mostraram-se fatores protetores ao aparecimento dos sintomas depressivos. CONCLUSÕES Situação clínica adversa, desvantagem socioeconômica e pouca atividade social e sexual mostraram-se associadas aos sintomas depressivos em idosos.

  19. The Detectability and Localization Accuracy of Implanted Fiducial Markers Determined on In-Room Computerized Tomography (CT) and Electronic Portal Images (EPI)

    Many different methods of image guidance are available for radiotherapy treatment (IGRT). The aims of the study were (1) to determine the optimal diameter of gold markers for IGRT to the prostate; (2) to compare, using the Siemens Primatom, the relative merits of in-room computerized tomography (CT) and electronic portal image (EPI) for locating the marker seeds. Gold markers of differing widths were embedded in 2 phantoms (perspex slabs and anthropomorphic). Images were acquired with an amorphous silicon flat panel detector (Siemens Optivue 500) and with the in-room CT scanner (Siemens Somatom Balance). The EPIs were reviewed independently by 6 operators to determine which diameter marker could be best visualized. The optimal marker technique was determined by comparing the investigators' observed marker co-ordinates with the known locations within the phantom. The visibility of all markers on anterior-posterior EPIs was 100%. On the lateral EPI, of a possible 180 visualizations of 1.2-, 1.0-, and 0.8-mm diameter markers, 176 (97.8%), 151 (83.9%), and 132 (73.3%), respectively, were successful. On EPI, the average deviation of fiducial markers from the known position was less than 0.5 mm in any direction. On CT, the largest deviation (2.17 mm) of markers from the known coordinate position was in the superior-inferior direction, reflecting the 3.0-mm slice thickness used. EPI accurately located internal markers in all dimensions. The availability of 'gold standard' CT imagery at the treatment unit does not improve how accurately the position of markers in a phantom can be defined compared with EPI. However, CT imagery does provide important soft tissue information, the benefits of which are being investigated further

  20. Validation study of the in vitro skin irritation test with the LabCyte EPI-MODEL24.

    Kojima, Hajime; Ando, Yoko; Idehara, Kenji; Katoh, Masakazu; Kosaka, Tadashi; Miyaoka, Etsuyoshi; Shinoda, Shinsuke; Suzuki, Tamie; Yamaguchi, Yoshihiro; Yoshimura, Isao; Yuasa, Atsuko; Watanabe, Yukihiko; Omori, Takashi

    2012-03-01

    A validation study on an in vitro skin irritation assay was performed with the reconstructed human epidermis (RhE) LabCyte EPI-MODEL24, developed by Japan Tissue Engineering Co. Ltd (Gamagori, Japan). The protocol that was followed in the current study was an optimised version of the EpiSkin protocol (LabCyte assay). According to the United Nations Globally Harmonised System (UN GHS) of classification for assessing the skin irritation potential of a chemical, 12 irritants and 13 non-irritants were validated by a minimum of six laboratories from the Japanese Society for Alternatives to Animal Experiments (JSAAE) skin irritation assay validation study management team (VMT). The 25 chemicals were listed in the European Centre for the Validation of Alternative Methods (ECVAM) performance standards. The reconstructed tissues were exposed to the chemicals for 15 minutes and incubated for 42 hours in fresh culture medium. Subsequently, the level of interleukin-1 alpha (IL-1 α) present in the conditioned medium was measured, and tissue viability was assessed by using the MTT assay. The results of the MTT assay obtained with the LabCyte EPI-MODEL24 (LabCyte MTT assay) demonstrated high within-laboratory and between-laboratory reproducibility, as well as high accuracy for use as a stand-alone assay to distinguish skin irritants from non-irritants. In addition, the IL-1α release measurements in the LabCyte assay were clearly unnecessary for the success of this model in the classification of chemicals for skin irritation potential. PMID:22558976

  1. Non-rigid registration and KLT filter to improve SNR and CNR in GRE-EPI myocardial perfusion imaging

    Mihai, Georgeta; Ding, Yu; Xue, Hui; Chung, Yiu-Cho; Rajagopalan, Sanjay; Guehring, Jens; Simonetti, Orlando P.

    2012-01-01

    The purpose of the study was to evaluate the effect of motion compensation by non-rigid registration combined with the Karhunen-Loeve Transform (KLT) filter on the signal to noise (SNR) and contrast-to-noise ratio (CNR) of hybrid gradient-echo echoplanar (GRE-EPI) first-pass myocardial perfusion imaging. Twenty one consecutive first-pass adenosine stress perfusion MR data sets interpreted positive for ischemia or infarction were processed by non-rigid Registration followed by KLT filtering. S...

  2. INDICADORES DE SUSTENTABILIDADE E SUA DIMENSÃO AMBIENTAL: ESI, EPI, LPI, PEGADA ECOLÓGICA, BIP 2020

    Evandro Brandão Barbosa; Helena Francinete da Silva Pimenta; Alberlane Pereira de Castro

    2013-01-01

    Os indicadores de Sustentabilidade apresentados neste artigo são: ESI – Índice de Sustentabilidade Ambiental; EPI – Índice de Desempenho Ambiental; LPI – Índice Planeta Vivo; EF – Pegada Ecológica; BIP 2020 – Índice de Biodiversidade e Parceria 2020. A pesquisa comparou a metodologia, a abordagem da sustentabilidade, os temas abordados e os resultados obtidos (quando disponíveis) desses indicadores. A partir da busca de dados e informações em bibliografias sobre o tema, a fim de compreender c...

  3. Subsurface microbial ecology. Epi fluorescence direct counts; Ecologia microbica del sottosuolo: metodo di conta diretta in epifluorescenza

    Barra Caracciolo, A.; Silvestri, C.; Creo, C.; Izzo, G. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1998-07-01

    To the aim of recognize the importance of microorganisms in affecting or even determining the fate of xenobiotics in the subsurface environment evaluating bacteria concentration in a subsurface ecosystem, the report discusses a soil sample treatment method which has been developed for epi fluorescence direct counting with DAPI. [Italian] Lo studio discute un metodo di trattamento del campione per la conta diretta in epifluorescenza con un marcatore selettivo per il DNA, il DAPI, al fine di quantificare la concentrazione batterica del sottosuolo e studiare il ruolo dei microrganismi nella biodegradazione delle molecole esogene, ancora poco indagato.

  4. Modelling temporal stability of EPI time series using magnitude images acquired with multi-channel receiver coils.

    Chloe Hutton; Evelyne Balteau; Antoine Lutti; Oliver Josephs; Nikolaus Weiskopf

    2012-01-01

    In 2001, Krueger and Glover introduced a model describing the temporal SNR (tSNR) of an EPI time series as a function of image SNR (SNR(0)). This model has been used to study physiological noise in fMRI, to optimize fMRI acquisition parameters, and to estimate maximum attainable tSNR for a given set of MR image acquisition and processing parameters. In its current form, this noise model requires the accurate estimation of image SNR. For multi-channel receiver coils, this is not straightforwar...

  5. Centro para la Salud Mundial del NCI anuncia becas de investigación para tecnologías portátiles

    El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo para mejorar la detección temprana, el diagnóstico y el tratamiento del cáncer.

  6. Estudio del NCI revela que la obesidad extrema puede acortar la esperanza de vida hasta en 14 años

    Los adultos con obesidad extrema tienen mayor riesgo de morir a edad más joven por cáncer y muchas otras causas entre ellas, enfermedades cardíacas, accidentes cerebrovasculares, diabetes y enfermedades del hígado y los riñones, según estudio del NCI.

  7. NCI en el congreso de ASCO: Breve reseña de los resultados de investigaciones de cánceres en mujeres

    En el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO) 2014 celebrado en junio en Chicago, se destacaron los resultados de varios estudios clínicos patrocinados por el NCI sobre cánceres en la mujer.

  8. An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells.

    Pereira, Joana M; Lopes-Rodrigues, Vanessa; Xavier, Cristina P R; Lima, M João; Lima, Raquel T; Ferreira, Isabel C F R; Vasconcelos, M Helena

    2016-01-01

    Tuberaria lignosa (Sweet) Samp. is found in European regions, and has antioxidant properties due to its composition in ascorbic acid and phenolic compounds. Given its traditional use and antioxidant properties, the tumor cell growth inhibitory potential of aqueous extracts from T. lignosa (prepared by infusion and decoction) was investigated in three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and HCT-15 (human colorectal adenocarcinoma). Both extracts inhibited the growth of these cell lines; the most potent one being the T. lignosa extract obtained by infusion in the NCI-H460 cells (GI50 of approximately 50 μg/mL). Further assays were carried out with this extract in NCI-H460 cells. At 100 μg/mL or 150 μg/mL it caused an increase in the percentage of cells in the G0/G1 phase and a decrease of cells in S phase of the cell cycle. Additionally, these concentrations caused an increase in the percentage of apoptotic cells. In agreement, a decrease in total poly (ADP-ribose) polymerase (PARP) and pro-caspase 3 levels was found. In conclusion, the T. lignosa extract obtained by infusion was more potent in NCI-H460 cells, altering the cell cycle progression and inducing apoptosis. This work highlights the importance of T. lignosa as a source of bioactive compounds with tumor cell growth inhibitory potential. PMID:27164073

  9. Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87

    Xiao-Chao Wei; Xin-Juan Wang; Kai-Chen; Lei Zhang; Yu Liang; Xin-Li Lin

    2001-01-01

    AIM To clone the cDNA fragment of human TRAIL (TNFrelated apoptosis inducing ligand) into a tetracyclineregulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCl-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells. METHODS The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracyclineresponsive element (TRE) to obtain the plasmid pRevTRETRAIL, which was transfected into a packaging cell line PT67. In addition, vector pRev-Tet- On and pRevTRE were also transfected into PT67 separately. After hygromycin and G418 selection, the viral titer was determined. The medium containing retroviral vectors was collected and used to transduce a gastric carcinoma cell line NCI-N87.The resulting cell line NCI-N87-Tet-On-TRE-TRAIL and a control cell line, NCI-N87-Tet-On-TRE, were established.TRAIL expression in the cell line was induced by incubating cells with doxycycline (Dox), which is a tetracycline analogue. The killing effect on gastric carcinoma cells was analyzed after induction. RESULTS The recombinant plasmid pRev-TRE-TRAIL was constructed. After hygromycin or G418 selection, the producer cell lines PT67-TRE, PT67-TRE-TRAIL and PT67TetOn were obtained, with titers of about 108CFU@ L-1 By transducing NCI-N87 cells with retroviral vectors from these cell lines, stable cell lines NCI-N87-Tet-On-TRETRAIL (NN3T) and control cell line NCI-N87-Tet-On-TRE (NN2T) were established. The growth curves of the selected cell lines were the same with the wild type NCIN87. When Dox was added, cell death was obvious in the test groups (29% -77%), whereas no difference was observed in control and wild type cell lines. With the addition of a medium from the test group, human leukemia cell line Jurkat was activated till death (83%), indicating the secretion of active TRAIL proteins from the test cells to the medium. CONCLUSION With the use of the

  10. Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III

    Shafi Tariq

    2012-06-01

    Full Text Available Abstract Background The Chronic Kidney Disease Epidemiology Collaboration equation for estimation of glomerular filtration rate (eGFRCKD-EPI improves GFR estimation compared with the Modification of Diet in Renal Disease Study equation (eGFRMDRD but its association with mortality in a nationally representative population sample in the US has not been studied. Methods We examined the association between eGFR and mortality among 16,010 participants of the Third National Health and Nutrition Examination Survey (NHANES III. Primary predictors were eGFRCKD-EPI and eGFRMDRD. Outcomes of interest were all-cause and cardiovascular disease (CVD mortality. Improvement in risk categorization with eGFRCKD-EPI was evaluated using adjusted relative hazard (HR and Net Reclassification Improvement (NRI. Results Overall, 26.9% of the population was reclassified to higher eGFR categories and 2.2% to lower eGFR categories by eGFRCKD-EPI, reducing the proportion of prevalent CKD classified as stage 3–5 from 45.6% to 28.8%. There were 3,620 deaths (1,540 from CVD during 215,082 person-years of follow-up (median, 14.3 years. Among those with eGFRMDRD 30–59 ml/min/1.73 m2, 19.4% were reclassified to eGFRCKD-EPI 60–89 ml/min/1.73 m2 and these individuals had a lower risk of all-cause mortality (adjusted HR, 0.53; 95% CI, 0.34-0.84 and CVD mortality (adjusted HR, 0.51; 95% CI, 0.27-0.96 compared with those not reclassified. Among those with eGFRMDRD >60 ml/min/1.73 m2, 0.5% were reclassified to lower eGFRCKD-EPI and these individuals had a higher risk of all-cause (adjusted HR, 1.31; 95% CI, 1.01-1.69 and CVD (adjusted HR, 1.42; 95% CI, 1.01-1.99 mortality compared with those not reclassified. Risk prediction improved with eGFRCKD-EPI; NRI was 0.21 for all-cause mortality (p  Conclusions eGFRCKD-EPI categories improve mortality risk stratification of individuals in the US population. If eGFRCKD-EPI replaces eGFRMDRD in the US, it will likely

  11. Comparison of Estimated Glomerular Filtration Rate by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equations with and without Cystatin C for Predicting Clinical Outcomes in Elderly Women

    Lim, Wai H.; Lewis, Joshua R.; Wong, Germaine; Turner, Robin M; Lim, Ee M.; Thompson, Peter L.; Prince, Richard L

    2014-01-01

    Background Reduced estimated glomerular filtration rate (eGFR) using the cystatin-C derived equations might be a better predictor of cardiovascular disease (CVD) mortality compared with the creatinine-derived equations, but this association remains unclear in elderly individuals. Aim The aims of this study were to compare the predictive values of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)-creatinine, CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C eGFR equations for ...

  12. The study on vitro effect of Pokemon expression suppression in human lung cancer cell line NCI-H520%抑制Pokemon蛋白表达对人肺癌细胞株NCI-H520的作用

    袁坦; 姜国忠; 李宏云

    2014-01-01

    目的 利用RNA干扰(RNAi)技术将针对性构建的重组质粒转染入人肺癌细胞株NCI-H520,观察下调Pokemon基因对人肺癌细胞生物学行为的影响.方法 利用Ambion公司设计软件设计针对Pokemon基因的2条小干扰RNA(siRNA)序列,并合成2对互补的siRNA编码DNA片段,定向克隆至RNAi-Ready pSIREN-RetroQ载体的BamH Ⅰ和EcoR Ⅰ位点,构建重组体质粒,分别命名为pSIREN-Pokemon-1和pSIREN-Pokemon-2,同时设立转染空载体对照组.Western blot检测人肺癌细胞中Pokemon蛋白表达,噻唑蓝(MTT)比色实验检测转染后细胞的增殖抑制结果,流式细胞分析技术检测转染后细胞周期的分布.结果 利用RNAi-Ready pSIRENR RetroQ载体构建的重组质粒可以成功抑制人肺癌细胞NCI-H520中Pokemon蛋白的表达.Western blot检测发现人肺癌细胞NCI-H520中Pokemon蛋白高水平表达,转染后其表达水平明显下降.转染后第3天,MTT比色实验显示pSIREN-Pokemon-1组(0.001 5 ±0.003 0)和pSIREN-Pokemon-2组(0.0086±0.0015)与pSIREN-Pokemon-0组(0.023 0 ±0.001 0)比较差异有统计学意义(P<0.05),而pSIREN-Pokemon-1与pSIREN-Pokemon-2组之间差异无统计学意义(P>0.05).流式细胞分析检测发现转染siRNA细胞与转染空载体细胞的细胞周期差异无统计学意义(P>0.05).pSIREN-Pokemon-1转染组及pSIREN-Pokemon-2转染组形成克隆的数量(18.0±0.3、16.0±0.4)明显低于pSIREN-Pokemon-0组(52.0±0.4,P<0.05).结论 使用pSIREN载体成功构建的重组质粒转染人肺癌细胞可有效抑制原癌基因Pokemon的表达.转染后细胞增殖受到抑制,生长速度减慢.抑制Pokemon蛋白表达对细胞周期无明显影响.靶向siRNA可以在人肺癌细胞中抑制Pokemon蛋白表达,负调节肺癌细胞生长.%Objective The aim of this research was to observe the influence of the low expression of Pokemom gene to biological behaviour of human lung cancer cell after transfecting the targeted recombinant plasmid

  13. 1st Iberian Robotics Conference

    Sanfeliu, Alberto; Ferre, Manuel; ROBOT2013; Advances in robotics

    2014-01-01

    This book contains the proceedings of the ROBOT 2013: FIRST IBERIAN ROBOTICS CONFERENCE and it can be said that included both state of the art and more practical presentations dealing with implementation problems, support technologies and future applications. A growing interest in Assistive Robotics, Agricultural Robotics, Field Robotics, Grasping and Dexterous Manipulation, Humanoid Robots, Intelligent Systems and Robotics, Marine Robotics, has been demonstrated by the very relevant number of contributions. Moreover, ROBOT2013 incorporates a special session on Legal and Ethical Aspects in Robotics that is becoming a topic of key relevance. This Conference was held in Madrid (28-29 November 2013), organised by the Sociedad Española para la Investigación y Desarrollo en Robótica (SEIDROB) and by the Centre for Automation and Robotics - CAR (Universidad Politécnica de Madrid (UPM) and Consejo Superior de Investigaciones Científicas (CSIC)), along with the co-operation of Grupo Temático de Robótica CEA-GT...

  14. Putting the Students 1st

    Ziegler, Elizabeth

    2005-01-01

    This article profiles Randy Jensen, the 2005 MetLife/NASSP National Middle Level Principal of the Year. As the principal of William Thomas Middle School in American Falls, Idaho, Jensen is a committed advocate for his students as they grapple with the challenges that come with being an adolescent and has adopted an open-door policy with his school…

  15. DNA barcoding of a new record of epi-endophytic green algae Ulvella leptochaete (Ulvellaceae, Chlorophyta) in India

    Felix Bast; Satej Bhushan; Aijaz Ahmad John

    2014-09-01

    Epi-endophytic green algae comprise one of the most diverse and phylogenetically primitive groups of green algae and are considered to be ubiquitous in the world’s oceans; however, no reports of these algae exist from India. Here we report the serendipitous discovery of Ulvella growing on intertidal green algae Cladophora glomerata and benthic red algae Laurencia obtusa collected from India. DNA barcodes at nuclear ribosomal DNA Internal Transcriber Spacer (nrDNA ITS) 1 and 2 regions for Indian isolates from the west and east coasts have been generated for the first time. Based on morphology and DNA barcoding, isolates were identified as Ulvella leptochaete. Phylogenetic reconstruction of concatenated dataset using Maximum Likelihood method differentiated Indian isolates from other accessions of this alga available in Genbank, albeit with low bootstrap support. Monophyly of Ulvella leptochaete was obvious in both of our phylogenetic analyses. With this first report of epi-endophytic algae from Indian territorial waters, the dire need to catalogue its cryptic diversity is highlighted and avenues of future research are discussed.

  16. Semipolar and nonpolar GaN epi-films grown on m-sapphire by plasma assisted molecular beam epitaxy

    We hereby report the development of non-polar epi-GaN films of usable quality, on an m-plane sapphire. Generally, it is difficult to obtain high-quality nonpolar material due to the planar anisotropic nature of the growth mode. However, we could achieve good quality epi-GaN films by involving controlled steps of nitridation. GaN epilayers were grown on m-plane (10-10) sapphire substrates using plasma assisted molecular beam epitaxy. The films grown on the nitridated surface resulted in a nonpolar (10-10) orientation while without nitridation caused a semipolar (11-22) orientation. Room temperature photoluminescence study showed that nonpolar GaN films have higher value of compressive strain as compared to semipolar GaN films, which was further confirmed by room temperature Raman spectroscopy. The room temperature UV photodetection of both films was investigated by measuring the I-V characteristics under UV light illumination. UV photodetectors fabricated on nonpolar GaN showed better characteristics, including higher external quantum efficiency, compared to photodetectors fabricated on semipolar GaN. X-ray rocking curves confirmed better crystallinity of semipolar as compared to nonpolar GaN which resulted in faster transit response of the device

  17. Assessing Organ Doses from Paediatric CT Scans—A Novel Approach for an Epidemiology Study (the EPI-CT Study

    Steven L. Simon

    2013-02-01

    Full Text Available The increasing worldwide use of paediatric computed tomography (CT has led to increasing concerns regarding the subsequent effects of exposure to radiation. In response to this concern, the international EPI-CT project was developed to study the risk of cancer in a large multi-country cohort. In radiation epidemiology, accurate estimates of organ-specific doses are essential. In EPI-CT, data collection is split into two time periods—before and after introduction of the Picture Archiving Communication System (PACS introduced in the 1990s. Prior to PACS, only sparse information about scanner settings is available from radiology departments. Hence, a multi-level approach was developed to retrieve information from a questionnaire, surveys, scientific publications, and expert interviews. For the years after PACS was introduced, scanner settings will be extracted from Digital Imaging and Communications in Medicine (DICOM headers, a protocol for storing medical imaging data. Radiation fields and X-ray interactions within the body will be simulated using phantoms of various ages and Monte-Carlo-based radiation transport calculations. Individual organ doses will be estimated for each child using an accepted calculation strategy, scanner settings, and the radiation transport calculations. Comprehensive analyses of missing and uncertain dosimetry data will be conducted to provide uncertainty distributions of doses.

  18. Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.

    Sharples, Adam P; Stewart, Claire E; Seaborne, Robert A

    2016-08-01

    Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle performance, maintaining metabolic function and supporting longevity and healthspan. Skeletal muscle is programmable and can 'remember' early-life metabolic stimuli affecting its function in adult life. In this review, the authors pose the question as to whether skeletal muscle has an 'epi'-memory? Following an initial encounter with an environmental stimulus, we discuss the underlying molecular and epigenetic mechanisms enabling skeletal muscle to adapt, should it re-encounter the stimulus in later life. We also define skeletal muscle memory and outline the scientific literature contributing to this field. Furthermore, we review the evidence for early-life nutrient stress and low birth weight in animals and human cohort studies, respectively, and discuss the underlying molecular mechanisms culminating in skeletal muscle dysfunction, metabolic disease and loss of skeletal muscle mass across the lifespan. We also summarize and discuss studies that isolate muscle stem cells from different environmental niches in vivo (physically active, diabetic, cachectic, aged) and how they reportedly remember this environment once isolated in vitro. Finally, we will outline the molecular and epigenetic mechanisms underlying skeletal muscle memory and review the epigenetic regulation of exercise-induced skeletal muscle adaptation, highlighting exercise interventions as suitable models to investigate skeletal muscle memory in humans. We believe that understanding the 'epi'-memory of skeletal muscle will enable the next generation of targeted therapies to promote muscle growth and reduce muscle loss to enable healthy aging. PMID:27102569

  19. Connecting Prompt and Afterglow GRB emission I. Investigating the impact of optical selection effects in the Epi - Eiso plane

    Turpin, D; Dezalay, J -P; Atteia, J-L; Klotz, A; Dornic, D

    2015-01-01

    Measuring GRB properties in their rest-frame is crucial to understand the physics at work in gamma-ray bursts. This can only be done for GRBs with known redshift. Since redshifts are usually measured from the optical spectrum of the afterglow, correlations between prompt and afterglow emissions may introduce biases in the distribution of rest-frame properties of the prompt emission, especially considering that we measure the redshift of only one third of Swift GRBs. In this paper we study the brightness of optical GRB afterglows and the role of optical selection effects in the distribution of various intrinsic properties of GRBs and on the Epi - Eiso relation discovered by Amati et al. (2002). Our analysis is based on a sample of 85 GRBs with good optical follow-up and well measured prompt emission. 71 of them have a measure of redshift and 14 have no redshift. We discuss the connection between the location of GRBs in the Epi-Eiso plane and their optical brightness measured two hours after the trigger in the ...

  20. Effects of irradiation of 290 MeV U-ions in GaN epi-layers

    In the present work, the resistivity, mobility and the carrier density at either room temperature or 77 K in 3-μm-thick n-GaN epi-layers irradiated with 290 MeV 238U32+ ions were tested with Hall measurements. It is found that the carrier mobility at 77 K is lower than that at room temperature in the specimens irradiated to fluences of the 1 × 109 and 1 × 1010 ions/cm2, showing a behavior different from the pristine specimen. The carrier density increases with ion fluence, and is above the dopant concentration when the ion fluence reaches 5 × 1010 ions/cm2. Moreover, the ionized impurity scattering plays a dominant role in the Hall effect after irradiation. A decrease of the ionized impurities due to the recombination of Ga vacancies (VGa-3) and the Ga interstitials (Ga(I)) was observed. The irradiation to the fluence of 5 × 1010 ions/cm2 produced N vacancies, which act as a kind of donor making the carrier density increase. The Raman spectra show that the E2 (high) mode shifts to a higher frequency meanwhile the FWTH increases after the irradiation, indicating there is an increase of strain in the irradiated GaN epi-layers. A consistency between the Raman spectra and the HRXRD spectra was found

  1. Conference Report. Repository experts met in Essen. Keen interest in the 1st technical discussion of repository mining organized by DMT and GNS

    In mid-March 2012, more than 200 participants met at the Essen technology service providers, DMT GmbH and Co. KG, for the '1st Essen Technical Discussion of Repository Mining.' In cooperation with GNS Gesellschaft fuer Nuklear-Service mbH of Essen, DMT had invited to a lecture event about this very topical subject. A new platform was to be created for exchanges of experience and discussions with colleagues in the field and with representatives of the competent authorities of the federal and state administrations. The 5 lectures presented by Georg Arens (Federal Ministry for the Environment, Nature Conservation and Nuclear Safety - BMU), Dr. Ute Blohm Hieber (Nuclear Power, Transport, Demolition and Waste Management Unit of the EU Commission - DG ENER-D.2), Matthias Ranft (Federal Office of Radiation Protection - BfS), Wilhelm Bollingerfehr (DBE Technology), and Dr. Philipp Birkhaeuser (Nationale Genossenschaft fuer die Lagerung radioaktiver Abfaelle - Nagra, Switzerland) discussed both national German and European as well as international topics and aspects of final storage of radioactive waste. (orig.)

  2. Proceedings of the 1st workshop of 'quantum complex phenomena' under the NIMS-RIKEN-JAEA cooperative research program on quantum beam science and technology

    The 1st workshop of the NIMS-RIKEN-JAEA Cooperative Research Program on Quantum Beam Science and Technology entitled 'Quantum Complex Phenomena' was held on June 14, 2007 at Center for Computational Science and e-Systems, Japan Atomic Energy Agency. This workshop is aimed to reveal the mechanism of quantum complex phenomena for the developments of next generation functional materials on the basis of the NIMS-RIKEN-JAEA Cooperative Research Program about Quantum Beam Science and Technology. This Cooperative Research Program was concluded on December 20, 2006, in order to lead the research and development of Quantum Beam Technology by the cooperation among RIKEN, NIMS, and JAEA. World top level researchers in addition to the instruments at quantum beam facilities of RIKEN, NIMS, and JAEA are combined to contribute to new innovations with international competence. Along this meaning, this workshop is aimed to introduce own research characteristics for mutual understandings and to discuss starting cooperative research activity for intimate research collaborations. This report includes abstracts and materials of the presentations in the workshop. (author)

  3. Report from the 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group.

    Schnell, Oliver; Standl, Eberhard; Catrinoiu, Doina; Genovese, Stefano; Lalic, Nebojsa; Skra, Jan; Valensi, Paul; Ceriello, Antonio

    2016-01-01

    The 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group was held during the annual meeting on 30 October 2015 in Munich. This summit was organized in light of recently published and numerous ongoing CVOTs on diabetes, which have emerged in response to the FDA and the EMA Guidelines. The CVOT Summit stands as a novel conference setup, with the aim of serving as a reference meeting for all topics related to CVOTs in diabetes. Members of the steering committee of the D&CVD EASD Study Group constitute the backbone of the summit. It included presentations of key results on DPP-4 inhibitors, GLP-1-Analogues, SGLT-2 inhibitors, acarbose and insulins. Diabetologists' and cardiologists' perspective on the potential need of new study designs were also highlighted. Furthermore, panel discussions on the design of CVOTs on diabetes were included in the program. The D&CVD EASD Study Group will continue its activity. In-depth discussions and presentations of new CVOTs like LEADER, will be resumed at the 2nd CVOT on diabetes of the D&CVD EASD Study Group, which will be held from 20-22 October 2016 in Munich ( http://www.dcvd.org). PMID:26892706

  4. Metastatic non-small-cell lung cancer: consensus on pathology and molecular tests, first-line, second-line, and third-line therapy: 1st ESMO Consensus Conference in Lung Cancer; Lugano 2010

    Felip, E; Gridelli, C; Baas, P;

    2011-01-01

    The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21 and 22 May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics, medical oncology, surgical oncology and radiation oncology. Before the...

  5. Competition to design a new logo for the CERN Staff Association : an award ceremony was held on Friday 1st March in the Main building in the presence of the six laureates.

    Jacques Hervé Fichet

    2013-01-01

    The six laureates received a price offered as follows: 1st prize: an Ezee Suisse electric bike. - 2nd prize (equal second) : a voucher for Go Sport with a value of 200 €. - 4th to 6th prize: a voucher for Go Sport with a value of 50 €

  6. The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

    Kaluzhny, Yulia; Kandárová, Helena; Handa, Yuki; DeLuca, Jane; Truong, Thoa; Hunter, Amy; Kearney, Paul; d'Argembeau-Thornton, Laurence; Klausner, Mitchell

    2015-05-01

    The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other consumer products are required for the safety assessment of materials that intentionally, or inadvertently, come into contact with the eye. The EpiOcular Eye Irritation Test (EIT), which uses the normal human cell-based EpiOcular™ tissue model, was developed to address this need. The EpiOcular-EIT is able to discriminate, with high sensitivity and accuracy, between ocular irritant/corrosive materials and those that require no labelling. Although the original EpiOcular-EIT protocol was successfully pre-validated in an international, multicentre study sponsored by COLIPA (the predecessor to Cosmetics Europe), data from two larger studies (the EURL ECVAM-COLIPA validation study and an independent in-house validation at BASF SE) resulted in a sensitivity for the protocol for solids that was below the acceptance criteria set by the Validation Management Group (VMG) for eye irritation, and indicated the need for improvement of the assay's sensitivity for solids. By increasing the exposure time for solid materials from 90 minutes to 6 hours, the optimised EpiOcular-EIT protocol achieved 100% sensitivity, 68.4% specificity and 84.6% accuracy, thereby meeting all the acceptance criteria set by the VMG. In addition, to satisfy the needs of Japan and the Pacific region, the EpiOcular-EIT method was evaluated for its performance after extended shipment and storage of the tissues (4-5 days), and it was confirmed that the assay performs with similar levels of sensitivity, specificity and reproducibility in these circumstances. PMID:25995013

  7. El perfil acadèmic de sortida dels psicòlegs de les organitzacions i el perfil professional d'entrada del tècnic júnior en Recursos Humans des de la perspectiva de les competències

    Chaves Lechuga, Antonio

    2007-01-01

    Centrada en l'àmbit de la formació universitària de competències, aquesta tesi doctoral estudia el nivell de competències dels estudiants de l'últim curs de Psicologia de les Organitzacions de la Facultat de Psicologia, Ciències de l'Educació i de l'Esport Blanquerna, de la Universitat Ramon Llull. El focus de la investigació és doble: Per una banda, es comparen les competències dels subjectes al final de la seva carrera amb les competències del perfil d'una categoria professional concreta, l...

  8. Other compounds isolated from Simira glaziovii and the {sup 1}H and {sup 13}C NMR chemical shift assignments of new 1-epi-castanopsol

    Araujo, Marcelo F. de; Vieira, Ivo J. Curcino [Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ (Brazil). Dept. de Quimica; Braz-Filho, Raimundo [Universidade Estadual do Norte Fluminense (UENF), Campos dos Goytacases, RJ (Brazil). Centro de Ciencias Tecnologicas. Lab. de Ciencias Quimicas; Carvalho, Mario G. de, E-mail: mgeraldo@ufrrj.br [Universidade Federal do Rio de Janeiro (NPPN/UFRJ), RJ (Brazil). Centro de Ciencias da Saude. Nucleo de Pesquisa em Produtos Naturais

    2012-07-01

    A new triterpene, 1-epi-castanopsol, besides eleven known compounds: sitosterol, stigmasterol, campesterol, lupeol, lupenone, simirane B, syringaresinol, scopoletin, isofraxidin, 6,7,8-trimethoxycoumarin and harman, were isolated from the wood of Simira glaziovii. The structures of the known compounds were defined by 1D, 2D {sup 1}H, {sup 13}C NMR spectra data analyses and comparison with literature data. The detailed spectral data analyses allowed the definition of the structure of the new 1-epi isomer of castanopsol and performance of {sup 1}H and {sup 13}C NMR chemical shift assignments. (author)

  9. Other compounds isolated from Simira glaziovii and the 1H and 13C NMR chemical shift assignments of new 1-epi-castanopsol

    A new triterpene, 1-epi-castanopsol, besides eleven known compounds: sitosterol, stigmasterol, campesterol, lupeol, lupenone, simirane B, syringaresinol, scopoletin, isofraxidin, 6,7,8-trimethoxycoumarin and harman, were isolated from the wood of Simira glaziovii. The structures of the known compounds were defined by 1D, 2D 1H, 13C NMR spectra data analyses and comparison with literature data. The detailed spectral data analyses allowed the definition of the structure of the new 1-epi isomer of castanopsol and performance of 1H and 13C NMR chemical shift assignments. (author)

  10. Comparison of estimated glomerular filtration rate by the chronic kidney disease epidemiology collaboration (CKD-EPI equations with and without Cystatin C for predicting clinical outcomes in elderly women.

    Wai H Lim

    Full Text Available BACKGROUND: Reduced estimated glomerular filtration rate (eGFR using the cystatin-C derived equations might be a better predictor of cardiovascular disease (CVD mortality compared with the creatinine-derived equations, but this association remains unclear in elderly individuals. AIM: The aims of this study were to compare the predictive values of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI-creatinine, CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C eGFR equations for all-cause mortality and CVD events (hospitalizations±mortality. METHODS: Prospective cohort study of 1165 elderly women aged>70 years. Associations between eGFR and outcomes were examined using Cox regression analysis. Test accuracy of eGFR equations for predicting outcomes was examined using Receiver Operating Characteristic (ROC analysis and net reclassification improvement (NRI. RESULTS: Risk of all-cause mortality for every incremental reduction in eGFR determined using CKD-EPI-creatinine, CKD-EPI-cystatin C and the CKD-EPI-creatinine-cystatic C equations was similar. Areas under the ROC curves of CKD-EPI-creatinine, CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C equations for all-cause mortality were 0.604 (95%CI 0.561-0.647, 0.606 (95%CI 0.563-0.649; p = 0.963 and 0.606 (95%CI 0.563-0.649; p = 0.894 respectively. For all-cause mortality, there was no improvement in the reclassification of eGFR categories using the CKD-EPI-cystatin C (NRI -4.1%; p = 0.401 and CKD-EPI-creatinine-cystatin C (NRI -1.2%; p = 0.748 compared with CKD-EPI-creatinine equation. Similar findings were observed for CVD events. CONCLUSION: eGFR derived from CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C equations did not improve the accuracy or predictive ability for clinical events compared to CKD-EPI-creatinine equation in this cohort of elderly women.

  11. Effect of Kang-Fu-Gan-He-Ji 1st on Function of Pepsin in SD Rats%抗复感合剂Ⅰ号对SD大鼠胃蛋白酶的影响

    潘利忠; 张晓春; 王力宁; 李伟伟

    2013-01-01

    目的:观察抗复感合剂Ⅰ号对SD大鼠胃蛋白酶的影响.方法:将SD大鼠30只,随机分为3组,抗复感合剂Ⅰ号高剂量组、抗复感合剂Ⅰ号低剂量组和正常对照组,每组10只.结果:抗复感合剂Ⅰ号高、低剂量组对大鼠胃蛋白酶的影响与正常对照组比较无显著性差异.结论:抗复感合剂Ⅰ号对大鼠胃蛋白酶无明显的影响.%Objective:To clarify the efficacy and safety of Kang-fu-gan-he-ji 1st by observation on the function of Pepsin in SD rats by Pharmacodynamics.Methods:30 mouse were divided into 3 groups,with 10 rats in each group,such as Kang-fu-gan-he-ji 1st high dose group,Kang-fu-gan-he-ji 1st low dose group,and normal control group.Results:Compared with Kang-fu-gan-he-ji 1st high dose group and low dose group both can' t decline Pepsin in SD rats significantly.Conclusion:High dose and low dose Kang-fu-gan-he-ji 1st havn' t adverse effect on the fuction of Pepsin in SD rats.

  12. Cx43基因修饰对人肺鳞癌NCI-H226细胞增殖和迁移能力的影响

    勾建强; 张秀义

    2015-01-01

    目的:通过重组质粒pBudCE4.1-Cx43转染人肺鳞癌NCI-H226细胞,探讨Cx43基因对细胞的生长、细胞周期及肿瘤迁移等的作用。方法用LipofectamineTM2000转染的方法将重组表达质粒pBudCE4.1-Cx43转染人肺鳞癌 NCI-H226细胞,通过 RT-PCR、Western 印迹检测 Cx43在转染后的mRNA和蛋白的表达情况,划痕染料示踪法检测细胞间通讯功能,流式细胞仪检测细胞周期并通过CCK-8增殖实验、划痕愈合实验、细胞侵袭实验评价转染Cx43基因对人肺鳞癌NCI-H226细胞增殖、迁移、侵袭能力的影响。结果实验组 Cx43 mRNA和蛋白表达较对照组和空白组显著升高(P<0.05);细胞传递的荧光强度较对照组和空白组显著升高(P<0.01),实验组细胞的生长速度明显减慢,细胞周期被阻滞在 G0/G1期,S期细胞数明显减少(P<0.05)。与对照组和空白组相比,实验组 NCI-H226细胞增殖受到明显抑制(P<0.001),尤以72 h 为著。实验组迁移能力、NCI-H226细胞的侵袭能力显著下降(P<0.05)。结论转染Cx43基可抑制人肺鳞癌NCI-H226细胞的迁移能力,并抑制肿瘤细胞增殖。

  13. epiPATH: an information system for the storage and management of molecular epidemiology data from infectious pathogens

    González-Candelas Fernando

    2007-04-01

    Full Text Available Abstract Background Most research scientists working in the fields of molecular epidemiology, population and evolutionary genetics are confronted with the management of large volumes of data. Moreover, the data used in studies of infectious diseases are complex and usually derive from different institutions such as hospitals or laboratories. Since no public database scheme incorporating clinical and epidemiological information about patients and molecular information about pathogens is currently available, we have developed an information system, composed by a main database and a web-based interface, which integrates both types of data and satisfies requirements of good organization, simple accessibility, data security and multi-user support. Results From the moment a patient arrives to a hospital or health centre until the processing and analysis of molecular sequences obtained from infectious pathogens in the laboratory, lots of information is collected from different sources. We have divided the most relevant data into 12 conceptual modules around which we have organized the database schema. Our schema is very complete and it covers many aspects of sample sources, samples, laboratory processes, molecular sequences, phylogenetics results, clinical tests and results, clinical information, treatments, pathogens, transmissions, outbreaks and bibliographic information. Communication between end-users and the selected Relational Database Management System (RDMS is carried out by default through a command-line window or through a user-friendly, web-based interface which provides access and management tools for the data. Conclusion epiPATH is an information system for managing clinical and molecular information from infectious diseases. It facilitates daily work related to infectious pathogens and sequences obtained from them. This software is intended for local installation in order to safeguard private data and provides advanced SQL-users the

  14. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan

    Soofi Sajid

    2012-01-01

    Full Text Available Abstract Background Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school enrolment is high, schools provide a cost effective opportunity for vaccination. Prior to start of a school-based typhoid vaccination program, interviews were conducted with staff of educational institutions in two townships of Karachi, Pakistan to collect baseline information about the school system and to plan a typhoid vaccination program. Data collection teams administered a structured questionnaire to all schools in the two townships. The administrative staff was requested information on school fee, class enrolment, past history of involvement and willingness of parents to participate in a vaccination campaign. Results A total of 304,836 students were enrolled in 1,096 public, private, and religious schools (Madrasahs of the two towns. Five percent of schools refused to participate in the school census. Twenty-five percent of schools had a total enrolment of less than 100 students whereas 3% had more than 1,000 students. Health education programs were available in less than 8% of public schools, 17% of private schools, and 14% of Madrasahs. One-quarter of public schools, 41% of private schools, and 43% of Madrasahs had previously participated in a school-based vaccination campaign. The most common vaccination campaign in which schools participated was Polio eradication program. Cost of the vaccine, side effects, and parents' lack of information were highlighted as important limiting factors by school administration for school-based immunization programs. Permission from parents, appropriateness of vaccine-related information, and involvement of teachers were considered as important factors to improve participation. Conclusions Health

  15. epiPATH: an information system for the storage and management of molecular epidemiology data from infectious pathogens

    Amadoz, Alicia; González-Candelas, Fernando

    2007-01-01

    Background Most research scientists working in the fields of molecular epidemiology, population and evolutionary genetics are confronted with the management of large volumes of data. Moreover, the data used in studies of infectious diseases are complex and usually derive from different institutions such as hospitals or laboratories. Since no public database scheme incorporating clinical and epidemiological information about patients and molecular information about pathogens is currently available, we have developed an information system, composed by a main database and a web-based interface, which integrates both types of data and satisfies requirements of good organization, simple accessibility, data security and multi-user support. Results From the moment a patient arrives to a hospital or health centre until the processing and analysis of molecular sequences obtained from infectious pathogens in the laboratory, lots of information is collected from different sources. We have divided the most relevant data into 12 conceptual modules around which we have organized the database schema. Our schema is very complete and it covers many aspects of sample sources, samples, laboratory processes, molecular sequences, phylogenetics results, clinical tests and results, clinical information, treatments, pathogens, transmissions, outbreaks and bibliographic information. Communication between end-users and the selected Relational Database Management System (RDMS) is carried out by default through a command-line window or through a user-friendly, web-based interface which provides access and management tools for the data. Conclusion epiPATH is an information system for managing clinical and molecular information from infectious diseases. It facilitates daily work related to infectious pathogens and sequences obtained from them. This software is intended for local installation in order to safeguard private data and provides advanced SQL-users the flexibility to adapt it to their

  16. Experiències de realitat augmentada en biblioteques : estat de la qüestió

    Arroyo Vázquez, Natalia

    2016-06-01

    Full Text Available Objectiu: donar a conèixer les experiències més significatives d'ús de la realitat augmentada en biblioteques, fent una especial atenció als resultats obtinguts, les aportacions i les limitacions que s'han de tenir en compte. -- Metodologia: revisió bibliogràfica, selecció i anàlisi d'experiències sobre l'ús de la realitat augmentada en biblioteques. -- Resultats: malgrat ser una tecnologia recent, els exemples d'ús de la realitat augmentada en biblioteques són diversos. No obstant això, es fa necessari donar a conèixer els resultats d'aquestes experiències, de manera que puguin servir no solament com a model, sinó també per conèixer què és el que funciona. Es presenta als professionals un catàleg d'usos de la realitat augmentada en biblioteques, dels quals s'analitzen de forma crítica els possibles beneficis i limitacions, i s'agrupen en set apartats segons la utilitat: geolocalització, contextualització històrica, exposicions i altres activitats, publicacions, enriquiment dels espais físics, alfabetització i ludificació i, finalment, usos professionals.Objetivo: dar a conocer las experiencias más significativas de uso de la realidad aumentada en bibliotecas, con una especial atención a los resultados obtenidos, las aportaciones y las limitaciones que se deben tener en cuenta. -- Metodología: revisión bibliográfica, selección y análisis de experiencias sobre el uso de la realidad aumentada en bibliotecas. -- Resultados: a pesar de ser una tecnología reciente, son varios los ejemplos de uso de la realidad aumentada en bibliotecas. Sin embargo, se hace necesario dar a conocer los resultados de dichas experiencias, de forma que puedan servir no solo como modelo, sino también para conocer qué es lo que funciona. Se presenta a los profesionales un catálogo de usos de la realidad aumentada en bibliotecas, analizados de forma crítica sus posibles beneficios y limitaciones, agrupados en siete apartados según la

  17. Experiències de realitat augmentada en biblioteques : estat de la qüestió

    Arroyo Vázquez, Natalia

    2016-06-01

    Full Text Available Objectiu: donar a conèixer les experiències més significatives d'ús de la realitat augmentada en biblioteques, amb una especial atenció als resultats obtinguts, les aportacions i les limitacions que s'han de tenir en compte. -- Metodologia: revisió bibliogràfica, selecció i anàlisi d'experiències sobre l'ús de realitat augmentada en biblioteques. -- Resultats: tot i ser una tecnologia recent, són diversos els exemples d'ús de la realitat augmentada en biblioteques. No obstant això, es fa necessari donar a conèixer els resultats d'aquestes experiències, de manera que puguin servir no solament com a model, sinó també per conèixer què és el que funciona. Es presenta als professionals un catàleg d'usos de la realitat augmentada en biblioteques, dels quals s'analitzen de forma crítica els possibles beneficis i limitacions, i s'agrupen en set apartats segons la utilitat: geolocalització, contextualització històrica, exposicions i altres activitats, publicacions, enriquiment dels espais físics, alfabetització i ludificació i, finalment, usos professionals.Objetivo: dar a conocer las experiencias más significativas de uso de la realidad aumentada en bibliotecas, con una especial atención a los resultados obtenidos, las aportaciones y las limitaciones que se deben tener en cuenta. -- Metodología: revisión bibliográfica, selección y análisis de experiencias sobre el uso de realidad aumentada en bibliotecas. -- Resultados: a pesar de ser una tecnología reciente, son varios los ejemplos de uso de la realidad aumentada en bibliotecas. Sin embargo, se hace necesario dar a conocer los resultados de dichas experiencias, de forma que puedan servir no solo como modelo, sino también para conocer qué es lo que funciona. Se presenta a los profesionales un catálogo de usos de la realidad aumentada en bibliotecas, analizados de forma crítica sus posibles beneficios y limitaciones, agrupados en siete apartados según la utilidad

  18. MO-E-BRF-01: Research Opportunities in Technology for Innovation in Radiation Oncology (Highlight of ASTRO NCI 2013 Workshop)

    Hahn, S [University of Pennsylvania, Philadelphia, PA (United States); Jaffray, D [Princess Margaret Hospital, Toronto, ON (Canada); Chetty, I [Henry Ford Health System, Detroit, MI (United States); Benedict, S [UC Davis Cancer Center, Sacramento, CA (United States)

    2014-06-15

    Radiotherapy is one of the most effective treatments for solid tumors, in large part due to significant technological advances associated with, for instance, the ability to target tumors to very high levels of accuracy (within millimeters). Technological advances have played a central role in the success of radiation therapy as an oncologic treatment option for patients. ASTRO, AAPM and NCI sponsored a workshop “Technology for Innovation in Radiation Oncology” at the NCI campus in Bethesda, MD on June 13–14, 2013. The purpose of this workshop was to bring together expert clinicians and scientists to discuss the role of disruptive technologies in radiation oncology, in particular with regard to how they are being developed and translated to clinical practice in the face of current and future challenges and opportunities. The technologies discussed encompassed imaging and delivery aspects, along with methods to enable/facilitate application of them in the clinic. Measures for assessment of the performance of these technologies, such as techniques to validate quantitative imaging, were reviewed. Novel delivery technologies, incorporating efficient and safe delivery mechanisms enabled by development of tools for process automation and the associated field of oncology informatics formed one of the central themes of the workshop. The discussion on disruptive technologies was grounded in the need for evidence of efficacy. Scientists in the areas of technology assessment and bioinformatics provided expert views on different approaches toward evaluation of technology efficacy. Clinicians well versed in clinical trials incorporating disruptive technologies (e.g. SBRT for early stage lung cancer) discussed the important role of these technologies in significantly improving local tumor control and survival for these cohorts of patients. Recommendations summary focused on the opportunities associated with translating the technologies into the clinic and assessing their

  19. MO-E-BRF-01: Research Opportunities in Technology for Innovation in Radiation Oncology (Highlight of ASTRO NCI 2013 Workshop)

    Radiotherapy is one of the most effective treatments for solid tumors, in large part due to significant technological advances associated with, for instance, the ability to target tumors to very high levels of accuracy (within millimeters). Technological advances have played a central role in the success of radiation therapy as an oncologic treatment option for patients. ASTRO, AAPM and NCI sponsored a workshop “Technology for Innovation in Radiation Oncology” at the NCI campus in Bethesda, MD on June 13–14, 2013. The purpose of this workshop was to bring together expert clinicians and scientists to discuss the role of disruptive technologies in radiation oncology, in particular with regard to how they are being developed and translated to clinical practice in the face of current and future challenges and opportunities. The technologies discussed encompassed imaging and delivery aspects, along with methods to enable/facilitate application of them in the clinic. Measures for assessment of the performance of these technologies, such as techniques to validate quantitative imaging, were reviewed. Novel delivery technologies, incorporating efficient and safe delivery mechanisms enabled by development of tools for process automation and the associated field of oncology informatics formed one of the central themes of the workshop. The discussion on disruptive technologies was grounded in the need for evidence of efficacy. Scientists in the areas of technology assessment and bioinformatics provided expert views on different approaches toward evaluation of technology efficacy. Clinicians well versed in clinical trials incorporating disruptive technologies (e.g. SBRT for early stage lung cancer) discussed the important role of these technologies in significantly improving local tumor control and survival for these cohorts of patients. Recommendations summary focused on the opportunities associated with translating the technologies into the clinic and assessing their

  20. Source Process of the Solomon Islands Earthquake of April 1st, 2007 (Mw8.1) Based on SAR Data and its Tectonic Implications

    Mori, M.; Kato, T.; Furuya, M.; Ochi, T.; Miyazaki, S.; Aoki, Y.

    2008-12-01

    We analyzed SAR (Synthetic Aperture Radar) data to derive the crustal deformation due to the Solomon Islands earthquake (Mw8.1) that occurred on April 1st, 2007. Three tracks that cover the source areas were used and the image data taken before and after the earthquake were processed to make interferograms. Then, we examined the obtained interferograms if the previous two source models that were obtained by seismic wave form inversion analyses could reproduce them. However, none of the models were able to reproduce the crustal deformations derived from the SAR data analysis. Then, we tried to construct a source model that explains the observed crustal deformations well. We considered some geophysical data to constrain the source geometry; the multichannel reflection data and observed vertical deformations using coral reef survey. Considering these lines of evidence, we introduced two possible source geometries; one is single-segment model that assumes only shallow-dipping (10 deg.) main thrust ruptured, and the other is two-segment model that assumes both a high angle spray fault of 30 degree dip and the main thrust fault slipped. The comparison of models based on inversion analyses suggested that the two-segment model would be preferable. This result suggests that the Solomon Islands earthquake would be the first observed earthquake on a steeply dipping splay fault that ruptured off the main converging plate boundary. If this is the case, this earthquake might provide us with an important clue for understanding the mechanisms of land formation such as landward titling of the coastal terraces.