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Sample records for 16-cell stage transition

  1. Determinants of forward stage transitions : a Delphi study

    De Vet, E; Brug, J; De Nooijer, J; Dijkstra, A; De Vries, NK

    2005-01-01

    Insight into stage transition determinants is necessary to develop and evaluate stage-tailored health-promoting interventions. A three-round Delphi study among stages of change researchers was conducted to make an inventory of opinions and examine agreement on determinants of forward transitions bet

  2. Dynamics of Sleep Stage Transitions in Health and Disease

    Kishi, Akifumi; Struzik, Zbigniew R.; Natelson, Benjamin H.; Togo, Fumiharu; Yamamoto, Yoshiharu

    2007-07-01

    Sleep dynamics emerges from complex interactions between neuronal populations in many brain regions. Annotated sleep stages from electroencephalography (EEG) recordings could potentially provide a non-invasive way to obtain valuable insights into the mechanisms of these interactions, and ultimately into the very nature of sleep regulation. However, to date, sleep stage analysis has been restricted, only very recently expanding the scope of the traditional descriptive statistics to more dynamical concepts of the duration of and transitions between vigilance states and temporal evaluation of transition probabilities among different stages. Physiological and/or pathological implications of the dynamics of sleep stage transitions have, to date, not been investigated. Here, we study detailed duration and transition statistics among sleep stages in healthy humans and patients with chronic fatigue syndrome, known to be associated with disturbed sleep. We find that the durations of waking and non-REM sleep, in particular deep sleep (Stages III and IV), during the nighttime, follow a power-law probability distribution function, while REM sleep durations follow an exponential function, suggestive of complex underlying mechanisms governing the onset of light sleep. We also find a substantial number of REM to non-REM transitions in humans, while this transition is reported to be virtually non-existent in rats. Interestingly, the probability of this REM to non-REM transition is significantly lower in the patients than in controls, resulting in a significantly greater REM to awake, together with Stage I to awake, transition probability. This might potentially account for the reported poor sleep quality in the patients because the normal continuation of sleep after either the lightest or REM sleep is disrupted. We conclude that the dynamical transition analysis of sleep stages is useful for elucidating yet-to-be-determined human sleep regulation mechanisms with a

  3. "A Two-Stage Prediction Model for Web Page Transition"

    Makoto Abe

    2003-01-01

    Utilizing data from a log file, a two-stage model for step-ahead web page prediction that permits adaptive page customization in real-time is proposed. The first stage predicts the next page of a viewer based on a variant of a Markov transition matrix computed from page sequences of other visitors who read the same pages as that viewer did thus far. The second stage re-analyzes the incorrect exit/continuation predictions of the first stage through data mining, incorporating the visitor's view...

  4. Stages of Change or Changes of Stage? Predicting Transitions in Transtheoretical Model Stages in Relation to Healthy Food Choice

    Armitage, Christopher J.; Sheeran, Paschal; Conner, Mark; Arden, Madelynne A.

    2004-01-01

    Relatively little research has examined factors that account for transitions between transtheoretical model (TTM) stages of change. The present study (N=787) used sociodemographic, TTM, and theory of planned behavior (TPB) variables, as well as theory-driven interventions to predict changes in stage. Longitudinal analyses revealed that…

  5. On the transition of base flow recession from early stage to late stage

    Ghosh, Debapi K.; Wang, Dingbao; Zhu, Tingju

    2016-02-01

    This paper is focused on the transition of base flow recession from early stage to late stage. The volume flow rate that takes place when such a transition occurs is identified for each of the twenty-three recession events observed at the Panola Mountain Research Watershed (PMRW) in Georgia, USA, using a newly developed cumulative regression analysis method. Meanwhile, the flow at the watershed outlet, which was recorded when the discharge at the perennial stream head diminishes to zero, is identified for each recession event. As evidenced by a correlation coefficient of 0.90, these two characteristic flows are found to be highly correlated, suggesting a fundamental linkage between the transition of base flow recession from early stage to late stage and the drying up of ephemeral streams. During the early stage, the contraction of ephemeral streams largely controls the recession behavior, whereas in the late stage when perennial streams dominate the flowing streams, the contraction of flowing streams is minimal and groundwater hydraulics governs the recession behavior.

  6. Asymmetry and Basic Pathways in Sleep-Stage Transitions.

    Lo, Chung-Chuan; Bartsch, Ronny P; Ivanov, Plamen Ch

    2013-04-01

    We study dynamical aspects of sleep micro-architecture. We find that sleep dynamics exhibits a high degree of asymmetry, and that the entire class of sleep-stage transition pathways underlying the complexity of sleep dynamics throughout the night can be characterized by two independent asymmetric transition paths. These basic pathways remain stable under sleep disorders, even though the degree of asymmetry is significantly reduced. Our findings indicate an intriguing temporal organization in sleep dynamics at short time scales that is typical for physical systems exhibiting self-organized criticality (SOC). PMID:24653582

  7. Translational regulation during stage transitions in malaria parasites.

    Cui, Liwang; Lindner, Scott; Miao, Jun

    2015-04-01

    The complicated life cycle of the malaria parasite involves a vertebrate host and a mosquito vector, and translational regulation plays a prominent role in orchestrating the developmental events in the two transition stages: gametocytes and sporozoites. Translational regulation is executed in both global and transcript-specific manners. Plasmodium uses a conserved mechanism involving phosphorylation of eIF2α to repress global protein synthesis during the latent period of sporozoite development in the mosquito salivary glands. Transcript-specific translational regulation is achieved by a network of RNA-binding proteins (RBPs), among which the Dhh1 RNA helicase DOZI and Puf family RBPs are by far the best studied in Plasmodium. While the DOZI complex defines a new P granule with a role in protecting certain gametocyte mRNAs from degradation, the Puf proteins appear to repress expression of mRNAs in both gametocytes and sporozoites. These examples underscore the significance of translational regulation in Plasmodium development. PMID:25387887

  8. A Study of the Transition from the Foundation Stage to Key Stage 1. Research Report: SSU/2005/FR/013

    Sanders, Dawn; White, Gabrielle; Burge, Bethan; Sharp, Caroline; Eames, Anna; McEune, Rhona; Grayson, Hilary

    2005-01-01

    This study set out to provide an evidence base concerning the effectiveness of the transition from the Foundation Stage (which applies to children aged three to five years) and Year 1 (for children aged five to six). The study had two main aims: (1) to provide a solid evidence base about the effectiveness of the transition from the Foundation…

  9. Staging transition: the Oresteia in post-apartheid South Africa

    Weyenberg, van, S.J.B.; Bal, M; Hernández-Navarro, M.Á.

    2011-01-01

    Aeschylus' Oresteia dramatizes the meaning and political deployment of justice, concluding with the transformation of justice as vengeance into the legal justice of Athens's new democracy. In this essay, I examine two dramatic texts that draw on the Oresteia within another context of transitional justice: post-apartheid South Africa. In Mark Fleishman's In the City of Paradise and Yael Farber's Molora the distorted family relations within the house of Atreus come to represent the distorted re...

  10. Household Life-Cycle Stages, Transitions, and Product Expenditures.

    Wilkes, Robert E

    1995-01-01

    Data from the U.S. Bureau of Labor Statistics' Consumer Expenditure Survey provide empirical verification of changes in household spending across a wide variety of products as households pass from one stage of the household life cycle to another. Three spending patterns emerged: (1) a generalized inverted U pattern, with spending rising sharply as households shift from young single to young married, then remaining relatively high, and falling sharply at the older married and/or older single s...

  11. Emotional and Motivational Engagement at School Transition: A Qualitative Stage-Environment Fit Study

    Symonds, Jennifer; Hargreaves, Linda

    2016-01-01

    Adolescents typically like school less after making age-graded school transitions. Stage-environment fit theory (Eccles & Midgley, 1989) attributes this to a mismatch between developmental needs and new school environments. Our in vivo study provides a basis for future quantitative designs by uncovering the most prevalent stage-environment…

  12. Transition from the preoperational stage of thinking to the concrete logical stage

    Polanc, Ana

    2013-01-01

    In the theoretical part, I focused on the method and cognitive development theory of Jean Piaget, I presented the factors of cognitive development and described the course of development based on four specific stages of the development of thinking. I compared the mental operations (conservation, serration and egocentrism) and the differences between the answers that children provided, according to the level of thinking at which the child is. I also listed some critiques of Piaget's theory. ...

  13. Massive Shift in Gene Expression during Transitions between Developmental Stages of the Gall Midge, Mayetiola Destructor

    Chen, Ming-Shun; Liu, Sanzhen; Wang, Haiyan; Cheng, Xiaoyan; El Bouhssini, Mustapha; Whitworth, R. Jeff

    2016-01-01

    Mayetiola destructor is a destructive pest of wheat and has six developmental stages. Molecular mechanisms controlling the transition between developmental stages remain unknown. Here we analyzed genes that were expressed differentially between two successive developmental stages, including larvae at 1, 3, 5, and 7 days, pupae, and adults. A total of 17,344 genes were expressed during one or more of these studied stages. Among the expressed genes, 38–68% were differently expressed between two successive stages, with roughly equal percentages of up- and down-regulated genes. Analysis of the functions of the differentially expressed genes revealed that each developmental stage had some unique types of expressed genes that are characteristic of the physiology at that stage. This is the first genome-wide analysis of genes differentially expressed in different stages in a gall midge. The large dataset of up- and down-regulated genes in each stage of the insect shall be very useful for future research to elucidate mechanisms regulating insect development and other biological processes. PMID:27224654

  14. Diet and mortality rates in Sub-Saharan Africa: Stages in the nutrition transition

    Steyn Nelia P

    2011-10-01

    Full Text Available Abstract Background During the last century we have seen wide-reaching changes in diet, nutritional status and life expectancy. The change in diet and physical activity patterns has become known as the nutrition transition. At any given time, a country or region within a country may be at different stages within this transition. This paper examines a range of nutrition-related indicators for countries in Sub-Saharan Africa (SSA and attempts to develop a typical model of a country in transition. Methods Based on the availability of data, 40 countries in SSA were selected for analysis. Data were obtained from the World Health Organisation, Demographic and Health Surveys and the Food and Agriculture Organisation of the United Nations. Multiple linear regression analysis (MLRA was used to explore the determinants of infant mortality. A six point score was developed to identify each country's stage in the nutrition transition. Results MLRA showed that underweight-for-age, protein and the percentage of exclusively breastfed infants were associated with the infant mortality rate (IMR. The majority of countries (n = 26 used in the analysis had nutrition transition scores of zero and one. Most of them had a high prevalence of infant mortality, children that were stunted or underweight-for-age, small percentages of women that were overweight and obese, and low intakes of energy, protein, and fat. Countries with the highest scores include South Africa, Ghana, Gabon, Cape Verde and Senegal which had relatively low IMRs, high levels of obesity/overweight, and low levels of underweight in women, as well as high intakes of energy and fat. These countries display classic signs of a population well established in the nutrition-related non-communicable disease phase of the nutrition transition. Conclusions Countries in SSA are clearly undergoing a nutrition transition. More than half of them are still in the early stage, while a few have reached a point where

  15. Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy

    Christensen, Julie Anja Engelhard; Carrillo, Oscar; Leary, Eileen B.; Peppard, Paul E.; Young, Terry; Sørensen, Helge Bjarup Dissing; Jennum, Poul; Mignot, Emmanuel

    2015-01-01

    extracted from PSGs. The first 15 min of sleep were excluded when a nocturnal SOREMP was recorded. F0.1 measures and receiver operating characteristic curves were used to identify specific (≥98%) features. A data set of 136 patients and 510 sex- and age-matched controls was used for the training. A data set......Objective: Type 1 narcolepsy/hypocretin deficiency is characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Short rapid eye movement (REM) latency (≤15 min) during nocturnal polysomnography (PSG) or during naps of the multiple sleep latency test (MSLT) defines a sleep......-onset REM sleep period (SOREMP), a diagnostic hallmark. We hypothesized that abnormal sleep transitions other than SOREMPs can be identified in type 1 narcolepsy. Methods: Sleep-stage transitions (one to 10 epochs to one to five epochs of any other stage) and bout length features (one to 10 epochs) were...

  16. Nucleation kinetics and crystal growth with fluctuating rates at the intermediate stage of phase transitions

    Crystal growth kinetics accompanied by particle growth with fluctuating rates at the intermediate stage of phase transitions is analyzed theoretically. The integro-differential model of governing equations is solved analytically for size-independent growth rates and arbitrary dependences of the nucleation frequency on supercooling/supersaturation. Two important cases of Weber–Volmer–Frenkel–Zel'dovich and Mier nucleation kinetics are detailed. A Fokker–Plank type equation for the crystal-size density distribution function is solved explicitly. (paper)

  17. Environmental correlates of peatland carbon fluxes in a thawing landscape: do transitional thaw stages matter?

    A. Malhotra

    2015-01-01

    Full Text Available Peatlands in discontinuous permafrost regions occur as a mosaic of wetland types, each with variable sensitivity to climate change. Permafrost thaw further increases the spatial heterogeneity in ecosystem structure and function in peatlands. Carbon (C fluxes are well characterized in end-member thaw stages such as fully intact or fully thawed permafrost but remain unconstrained for transitional stages that cover a significant area of thawing peatlands. Furthermore, changes in the environmental correlates of C fluxes, due to thaw are not well described: a requirement for modeling future changes to C storage of permafrost peatlands. We investigated C fluxes and their correlates in end-member and a number of transitional thaw stages in a sub-arctic peatland. Across peatland lumped CH4 and CO2 flux data had significant correlations with expected correlates such as water table depth, thaw depth, temperature, photosynthetically active radiation and vascular green area. Within individual thaw states, bivariate correlations as well as multiple regressions between C flux and environmental factors changed variably with increasing thaw. The variability in directions and magnitudes of correlates reflects the range of structural conditions that could be present along a thaw gradient. These structural changes correspond to changes in C flux controls, such as temperature and moisture, and their interactions. Temperature sensitivity of CH4 increased with increasing thaw in bivariate analyses, but lack of this trend in multiple regression analyses suggested cofounding effects of substrate or water limitation on the apparent temperature sensitivity. Our results emphasize the importance of incorporating transitional stages of thaw in landscape level C budgets and highlight that end-member or adjacent thaw stages do not adequately describe the variability in structure-function relationships present along a thaw gradient.

  18. Transitions in Physiologic Coupling: Sleep Stage and Age Dependence of Cardio-respiratory Phase Synchronization

    Bartsch, Ronny P.; Ivanov, Plamen Ch.

    2012-02-01

    Recent studies have focused on various features of cardiac and respiratory dynamics with the aim to better understand key aspects of the underlying neural control of these systems. We investigate how sleep influences cardio-respiratory coupling, and how the degree of this coupling changes with transitions across sleep stages in healthy young and elderly subjects. We analyze full night polysomnographic recordings of 189 healthy subjects (age range: 20 to 90 years). To probe cardio-respiratory coupling, we apply a novel phase synchronization analysis method to quantify the adjustment of rhythms between heartbeat and breathing signals. We investigate how cardio-respiratory synchronization changes with sleep-stage transitions and under healthy aging. We find a statistically significant difference in the degree of cardio-respiratory synchronization during different sleep stages for both young and elderly subjects and a significant decline of synchronization with age. This is a first evidence of how sleep regulation and aging influence a key nonlinear mechanism of physiologic coupling as quantified by the degree of phase synchronization between the cardiac and respiratory systems, which is of importance to develop adequate modeling approaches.

  19. Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage

    Dalheimer, Stacy L.; Zeng, Ling; Draves, Kevin E.; Hassaballa, Ashraf; Jiwa, Nasheena N.; Parrish, Torrey D.; Edward A Clark; Yankee, Thomas M.

    2009-01-01

    Positive selection of T cell precursors is the process by which a diverse T cell repertoire is established. Positive selection begins at the CD4+CD8+ double positive (DP) stage of development and involves at least two steps. First, DP thymocytes downregulate CD8 to become transitional single positive (TSP) CD4+ thymocytes. Then, cells are selected to become either mature SP CD4+ or mature SP CD8+ thymocytes. We sought to define the function of Gads during the two steps of positive selection b...

  20. Estimating transition probabilities for stage-based population projection matrices using capture-recapture data

    Nichols, J.D.; Sauer, J.R.; Pollock, K.H.; Hestbeck, J.B.

    1992-01-01

    In stage-based demography, animals are often categorized into size (or mass) classes, and size-based probabilities of surviving and changing mass classes must be estimated before demographic analyses can be conducted. In this paper, we develop two procedures for the estimation of mass transition probabilities from capture-recapture data. The first approach uses a multistate capture-recapture model that is parameterized directly with the transition probabilities of interest. Maximum likelihood estimates are then obtained numerically using program SURVIV. The second approach involves a modification of Pollock's robust design. Estimation proceeds by conditioning on animals caught in a particualr class at time i, and then using closed models to estimate the number of these that are alive in other classes at i + 1. Both methods are illustrated by application to meadow vole, Microtus pennsylvanicus, capture-recapture data. The two methods produced reasonable estimates that were similar. Advantages of these two approaches include the directness of estimation, the absence of need for restrictive assumptions about the independence of survival and growth, the testability of assumptions, and the testability of related hypotheses of ecological interest (e.g., the hypothesis of temporal variation in transition probabilities).

  1. Disruption of transitional stages in 24-h blood pressure in renal transplant recipients

    Marcelo E Katz

    2012-03-01

    Full Text Available Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor. Compared with matched controls, double-logistic fitting showed that the times for most of transitional stages (ascending systolic and descending systolic, diastolic and mean arterial pressure had a wider distribution along the 24 h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed the phase related changes, showing a wider distribution of times of peak (acrophases. We conclude that daily disruptions in renal transplant recipients can be explained not only by absence in diurnal variation, but also in changes in waveform-related parameters of the rhythm, and that distortions in the phase of the rhythm are the most consistent finding for the patients.

  2. Permafrost Thaw Induces Methane Oxidation in Transitional Thaw Stages in a Subarctic Peatland

    Perryman, C. R.; Kashi, N. N.; Malhotra, A.; McCalley, C. K.; Varner, R. K.

    2015-12-01

    Rising temperatures in the subarctic are accelerating permafrost thaw and increasing methane (CH4) emissions from subarctic peatlands. Methanotrophs in these peatlands can consume/oxidize CH4, potentially mitigating CH4 emissions in these peatlands. Oxidation rates can exceed 90% of CH4 production in some settings, depending on O2 and CH4 availability and environmental conditions. Malhotra and Roulet identified 10 thaw stages in Stordalen Mire near Abisko, Sweden (68°21'N,18°49'E ) with variable vegetation, environmental conditions, and associated CH4 emissions. We investigated potential methane oxidation rates across these thaw stages. Peat cores were extracted from two depths at each stage and incubated in 350ml glass jars at in situ temperatures and CH4 concentrations. Headspace samples were collected from each incubation jar over a 48-hour period and analyzed for CH4 concentration using flame ionization detection gas chromatography (GC-FID). Oxidation rates ranged from <0.1 to 17 μg of CH4 per gram of dry biomass per day. Water table depth and pore water pH were the strongest environmental correlates of oxidation (sample size = 56, p < 0.001). The highest potential oxidation rates were observed in collapsing palsa sites and recently collapsed sedge-dominated open water sites near palsa mounds. Our results suggest that permafrost thaw induces high CH4 oxidation rates by creating conditions ideal for both methanogenic and methanotrophic microbial communities. Our results also reinforce the importance of incorporating transitional thaw stages in landscape level carbon budgets of thawing peatlands emphasized by Malhotra and Roulet. Forthcoming microbial analysis and stable isotope analysis will further elucidate the factors controlling methane oxidation rates at Stordalen Mire.

  3. Successive stages and the role of natural vortex dislocations in three-dimensional wake transition

    Braza, M.; Faghani, D.; Persillon, H.

    2001-07-01

    The time-history of the development of the three-dimensional transition features in a nominally two-dimensional flow configuration is established for Reynolds number 220 in a cylinder wake. The identification of the successive stages that evolve very fast during experiments is possible by means of direct numerical simulation. The physical processes related to the creation of streamwise and vertical vorticity components and their impact on the spanwise waviness of the main von Kármán vortex filaments are analysed by means of the Craik Leibovich shearing instability mechanism and a comparative discussion is given with respect to the elliptic stability theory. This study proves the existence of a further stage in the three-dimensional transition, which substantially modifies the regular spanwise undulation. This is a systematic and repetitive development of natural vortex dislocations in the near wake. The definition of this kind of structure is provided, as well as its properties related to a drastic reduction of the fundamental frequency and to the selection of a lower path in the Strouhal Reynolds number relation. The induced amplitude modulation of the flow properties along the span is also evaluated. Quantification of these properties is carried out by using wavelet analysis and autoregressive modelling of the time series. The reasons for the development of natural vortex dislocations are analysed and related to specific modulations of the spanwise structure of the longitudinal velocity upstream separation. From this part of the study an optimum shape for the spanwise distribution of this component can be specified, able to trigger the vortex dislocations in wake flows and therefore useful to apply in the context of stability theory analyses and in further DNS studies.

  4. America's Next Great Ship: Space Launch System Core Stage Transitioning from Design to Manufacturing

    Birkenstock, Benjamin; Kauer, Roy

    2014-01-01

    The Space Launch System (SLS) Program is essential to achieving the Nation's and NASA's goal of human exploration and scientific investigation of the solar system. As a multi-element program with emphasis on safety, affordability, and sustainability, SLS is becoming America's next great ship of exploration. The SLS Core Stage includes avionics, main propulsion system, pressure vessels, thrust vector control, and structures. Boeing manufactures and assembles the SLS core stage at the Michoud Assembly Facility (MAF) in New Orleans, LA, a historical production center for Saturn V and Space Shuttle programs. As the transition from design to manufacturing progresses, the importance of a well-executed manufacturing, assembly, and operation (MA&O) plan is crucial to meeting performance objectives. Boeing employs classic techniques such as critical path analysis and facility requirements definition as well as innovative approaches such as Constraint Based Scheduling (CBS) and Cirtical Chain Project Management (CCPM) theory to provide a comprehensive suite of project management tools to manage the health of the baseline plan on both a macro (overall project) and micro level (factory areas). These tools coordinate data from multiple business systems and provide a robust network to support Material & Capacity Requirements Planning (MRP/CRP) and priorities. Coupled with these tools and a highly skilled workforce, Boeing is orchestrating the parallel buildup of five major sub assemblies throughout the factory. Boeing and NASA are transforming MAF to host state of the art processes, equipment and tooling, the most prominent of which is the Vertical Assembly Center (VAC), the largest weld tool in the world. In concert, a global supply chain is delivering a range of structural elements and component parts necessary to enable an on-time delivery of the integrated Core Stage. SLS is on plan to launch humanity into the next phase of space exploration.

  5. Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

    Tobias D Schneider

    Full Text Available Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative fluctuations in bulk histone modifications during development. To investigate this issue we analysed histones isolated from four different developmental stages of Xenopus laevis by mass spectrometry. In toto, we quantified 59 modification states on core histones H3 and H4 from blastula to tadpole stages. During this developmental period, we observed in general an increase in the unmodified states, and a shift from histone modifications associated with transcriptional activity to transcriptionally repressive histone marks. We also compared these naturally occurring patterns with the histone modifications of murine ES cells, detecting large differences in the methylation patterns of histone H3 lysines 27 and 36 between pluripotent ES cells and pluripotent cells from Xenopus blastulae. By combining all detected modification transitions we could cluster their patterns according to their embryonic origin, defining specific histone modification profiles (HMPs for each developmental stage. To our knowledge, this data set represents the first compendium of covalent histone modifications and their quantitative flux during normogenesis in a vertebrate model organism. The HMPs indicate a stepwise maturation of the embryonic epigenome, which may be causal to the progressing restriction of cellular potency during development.

  6. Survey of experimental and theoretical electron-impact ionization cross sections for transition metal ions in low stages of ionization

    Electron-ion crossed beams measurements and distorted-wave theory have been employed to make a study of electron-impact ionization for transition metal ions in low stages of ionization. The atomic ions Ti+, Ti2+, Ti3+, Fe+, Fe2+, Fe3+, Fe4+, Ni+, Ni2+, Ni3+, Cu+, Cu2+, and Cu3+ are examined

  7. Comparative Glycoproteome Analysis: Dynamics of Protein Glycosylation during Metamorphic Transition from Pelagic to Benthic Life Stages in Three Invertebrates

    Chandramouli, Kondethimmanahalli H.

    2012-02-03

    The life cycle of most benthic marine invertebrates has two distinct stages: the pelagic larval stage and the sessile juvenile stage. The transition between the larval stage and the juvenile stage is often abrupt and may be triggered by post-translational modification of proteins. Glycosylation, a very important post-translational modification, influences the biological activity of proteins. We used two-dimensional gel electrophoresis (2-DE) followed by glycoprotein-specific fluorescence staining and mass spectrometry with the goal of identifying glycosylation pattern changes during larval settlement and metamorphosis in barnacles, bryozoans, and polychaetes. Our results revealed substantial changes in the protein glycosylation patterns from larval to juvenile stages. Before metamorphosis, the degree of protein glycosylation was high in the barnacle Balanus (=Amphibalanus) amphitrite and the spionid polychaete Pseudopolydora vexillosa, whereas it increased after metamorphosis in the bryozoan Bugula neritina. We identified 19 abundant and differentially glycosylated proteins in these three species. Among the proteins, cellular stress- and metabolism-related proteins exhibited distinct glycosylation in B. amphitrite and B. neritina, whereas fatty acid metabolism-related proteins were abundantly glycosylated in P. vexillosa. Furthermore, the protein and gene expression analysis of some selected glycoproteins revealed that the degree of protein glycosylation did not always complement with transcriptional and translational changes associated with the larval-juvenile transition. The current study provides preliminary information on protein glycosylation in marine invertebrates that will serve as a solid basis for future comprehensive analysis of glycobiology during larval settlement and metamorphosis. © 2011 American Chemical Society.

  8. River Stage Influences on Uranium Transport in a Hydrologically Dynamic Groundwater-Surface Water Transition Zone

    Zachara, John M.; Chen, Xingyuan; Murray, Christopher J.; Hammond, Glenn

    2016-03-17

    A tightly spaced well-field within a groundwater uranium (U) plume in the groundwater-surface water transition zone was monitored for a three year period for groundwater elevation and dissolved solutes. The plume discharges to the Columbia River, which displays a dramatic spring stage surge resulting from mountain snowmelt. Groundwater exhibits a low hydrologic gradient and chemical differences with river water. River water intrudes the site in spring. Specific aims were to assess the impacts of river intrusion on dissolved uranium (Uaq), specific conductance (SpC), and other solutes, and to discriminate between transport, geochemical, and source term heterogeneity effects. Time series trends for Uaq and SpC were complex and displayed large temporal well-to well variability as a result of water table elevation fluctuations, river water intrusion, and changes in groundwater flow directions. The wells were clustered into subsets exhibiting common temporal behaviors resulting from the intrusion dynamics of river water and the location of source terms. Concentration hot spots were observed in groundwater that varied in location with increasing water table elevation. Heuristic reactive transport modeling with PFLOTRAN demonstrated that mobilized U was transported between wells and source terms in complex trajectories, and was diluted as river water entered and exited the groundwater system. While uranium time-series concentration trends varied significantly from year to year as a result of climate-caused differences in the spring hydrograph, common and partly predictable response patterns were observed that were driven by water table elevation, and the extent and duration of the river water intrusion event.

  9. Multiphasic multidetector-row CT (MDCT) in detection and staging of transitional cell carcinomas of the upper urinary tract

    The aim of this study was to evaluate the potential of multiphasic multidetector-row CT (MDCT) in the detection and staging of transitional cell carcinomas (TCC) of the upper urinary tract. We performed a retrospective chart review of 39 consecutive patients with 41 histologically verified TCC of the renal pelvis and/or the ureter. The urinary tract was examined using MDCT performing unenhanced and contrast-enhanced scans during the corticomedullary (CMP), nephrographic (NP) and pyelographic phase (PP). Tumors were staged according to the TNM classification. MDCT and histopathological findings were correlated. The attenuation of the lesions was documented in Hounsfield units (HU). In MDCT, all 41 TCC - including two multicentric TCC - were detected. TCC confined to the organ (stage 0a-II) was correctly staged in 28/29 tumors (96.6%). Stage III-IV tumors were correctly staged in 8/12 patients (66.6%). Overall, MDCT was accurate in predicting pathologic TNM stage in 36/41 upper urinary tract TCC (87.8%). There was no significant difference of mean attenuation of TCC between CMP, NP and PP (P>0.05). MDCT with its high spatial and temporal resolution is an accurate tool for detection TCC of the upper urinary tract, with 87.8% accuracy in predicting its stage. (orig.)

  10. Resonant Modes in a 1.6 Cells RF Gun

    Ferrario, Massimo; Ronsivalle, Concetta

    2007-09-01

    The SPARC photoinjector RF gun consists in the BNL/SLAC/UCLA 1.6 cell structure designed to resonate at 2856 MHz in the π mode. It will be demonstrated by a numerical modelization based on SUPERFISH code combined with the LC-circuit analysis that the two oscillating modes of the system usually indicated as 0-mode and π-mode (the operating mode) are in reality a π/3-mode-like and a π-mode-like. The consequences on the definition of the coupling coefficient and on the use of mode-separation based RF measurements are described.

  11. The big five personality traits and individual job performance growth trajectories in maintenance and transitional job stages.

    Thoresen, Carl J; Bradley, Jill C; Bliese, Paul D; Thoresen, Joseph D

    2004-10-01

    This study extends the literature on personality and job performance through the use of random coefficient modeling to test the validity of the Big Five personality traits in predicting overall sales performance and sales performance trajectories--or systematic patterns of performance growth--in 2 samples of pharmaceutical sales representatives at maintenance and transitional job stages (K. R. Murphy, 1989). In the maintenance sample, conscientiousness and extraversion were positively associated with between-person differences in total sales, whereas only conscientiousness predicted performance growth. In the transitional sample, agreeableness and openness to experience predicted overall performance differences and performance trends. All effects remained significant with job tenure statistically controlled. Possible explanations for these findings are offered, and theoretical and practical implications of findings are discussed. PMID:15506864

  12. Dewetting transition induced by surfactants in sessile droplets at the early evaporation stage.

    Zhong, Xin; Duan, Fei

    2016-01-14

    As surfactants are employed to control the wettability of solutions, we observe that the sessile droplet dewetting induced by autophobing exhibits a unique relation with the surfactant concentration. Below the critical micelle concentration (cmc) of the surfactant, the autophobic effect makes the droplet go through a rapid depinning at first (Phase 1) and then a relatively slower shrinkage (Phase 2). Unexpectedly, the rapid velocity of the three-phase contact line in Phase 1 shows a transition as the surfactant concentration increases above 0.043 cmc, while such a transition is absent for the velocity in Phase 2. The spreading of the sessile droplets as they form before retraction, the maximum contact angle led by dewetting, and the droplet lifetime are regularly sensitive to the surfactant concentration as well. These phenomena are correlated with the assembling structure and the adsorbed amount at different interfaces with the loading of surfactant inventory. PMID:26482037

  13. From cohabitation to marriage : couples' perceptions of the transition stage II of the family life cycle

    Kleinhen, Rachel M.

    1992-01-01

    Cohabitation, as a relationship form, is becoming much more common in the United States. Approximately half of the persons currently in their 30s cohabit prior to marriage and more than half of all recent marriages were preceded by cohabitation between those marrying. Through the use of in-depth interviews I studied the transition between this new form of "dating" and the traditional course of marriage. Couples who cohabited with each other prior to their marriage were inter...

  14. Lost in transition? Celtic language revitalization in Scotland and Wales: the primary to secondary school stage

    O'Hanlon, Fiona Malcolm

    2012-01-01

    The development of education through the medium of Celtic languages (here specifically Welsh and Scottish Gaelic) is often placed within a language planning framework in which Celtic-medium education is viewed as a means of sustaining a threatened language in the context of levels of intergenerational transmission which are insufficient to maintain speaker numbers. The primary to secondary school stage is a critical juncture from such a perspective, as language revitalization r...

  15. A transition-constrained discrete hidden Markov model for automatic sleep staging

    Pan Shing-Tai

    2012-08-01

    Full Text Available Abstract Background Approximately one-third of the human lifespan is spent sleeping. To diagnose sleep problems, all-night polysomnographic (PSG recordings including electroencephalograms (EEGs, electrooculograms (EOGs and electromyograms (EMGs, are usually acquired from the patient and scored by a well-trained expert according to Rechtschaffen & Kales (R&K rules. Visual sleep scoring is a time-consuming and subjective process. Therefore, the development of an automatic sleep scoring method is desirable. Method The EEG, EOG and EMG signals from twenty subjects were measured. In addition to selecting sleep characteristics based on the 1968 R&K rules, features utilized in other research were collected. Thirteen features were utilized including temporal and spectrum analyses of the EEG, EOG and EMG signals, and a total of 158 hours of sleep data were recorded. Ten subjects were used to train the Discrete Hidden Markov Model (DHMM, and the remaining ten were tested by the trained DHMM for recognition. Furthermore, the 2-fold cross validation was performed during this experiment. Results Overall agreement between the expert and the results presented is 85.29%. With the exception of S1, the sensitivities of each stage were more than 81%. The most accurate stage was SWS (94.9%, and the least-accurately classified stage was S1 ( Conclusion The results of the experiments demonstrate that the proposed method significantly enhances the recognition rate when compared with prior studies.

  16. Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

    Chua, Song Lin; Liu, Yang; Yam, Joey Kuok Hoong;

    2014-01-01

    Bacteria assume distinct lifestyles during the planktonic and biofilm modes of growth. Increased levels of the intracellular messenger c-di-GMP determine the transition from planktonic to biofilm growth, while a reduction causes biofilm dispersal. It is generally assumed that cells dispersed from...... biofilms immediately go into the planktonic growth phase. Here we use single-nucleotide resolution transcriptomic analysis to show that the physiology of dispersed cells from Pseudomonas aeruginosa biofilms is highly different from those of planktonic and biofilm cells. In dispersed cells, the expression...... of the small regulatory RNAs RsmY and RsmZ is downregulated, whereas secretion genes are induced. Dispersed cells are highly virulent against macrophages and Caenorhabditis elegans compared with planktonic cells. In addition, they are highly sensitive towards iron stress, and the combination of a...

  17. N-glycan transition of the early developmental stage in Oryza sativa.

    Horiuchi, Risa; Hirotsu, Naoki; Miyanishi, Nobumitsu

    2016-08-26

    N-Glycosylation is one of the post-translational modifications. In animals, N-glycans linked to proteins function in cell-cell recognition, sorting, transport, and other biological phenomena. However, in plants, N-glycan-mediated biological functions remain obscure. In a previous study, we showed that the main type of N-glycan transition is from the paucimannosidic to complex type before and after germination in Oryza sativa, suggesting that transitions of N-glycan, including those of glycoproteins and glycosyltransferases, are closely associated with plant growth. To further elucidate the relationship between N-glycan structure and plant growth, we analyzed the structures of N-glycans expressed in O. sativa seedlings grown under light conditions and performed comparative analyses of the structures in the shoot and root. The analyses show that fundamental N-glycan structures are common to the shoot and root, whereas paucimannosidic-type N-glycans dramatically decreased in the root grown under light conditions. Further, to investigate the effects of light on N-glycan structures in O. sativa seedlings, we analyzed N-glycan structures in O. sativa seedlings grown in the dark. Understandably, N-glycan expression in the root was almost unaffected by light. However, despite a marked difference in phenotype, N-glycan expression in the shoot was also unaffected by light. This result suggests that the shoot and root of O. sativa have different glycoproteins and distinct N-glycan synthetic systems. Thus, we propose that the N-glycan synthetic system of the O. sativa shoot is almost unaffected by light conditions and that many photosynthesis-related proteins are not modified by N-glycans. PMID:27320861

  18. Phase equilibrium in argon films stabilized by homogeneous surfaces and thermodynamics of two-stage melting transition

    Freezing of gases adsorbed on open surfaces (e.g., graphite) and in narrow pores is a widespread phenomenon which is a subject of a large number of publications. Modeling of the gas/liquid–solid transition is usually accomplished with a molecular simulation technique. However, quantitative analysis of the gas/liquid–solid coexistence and thermodynamic properties of the solid layer still encounters serious difficulties. This is mainly due to the effect of simulation box size on the lattice constant. Since the lattice constant is a function of loading and temperature, once the ordering transition has occurred, the simulation box size must be corrected in the course of simulation according to the Gibbs–Duhem equation. A significant problem is also associated with accurate prediction of the two-dimensional liquid–solid coexistence because of a small difference in densities of coexisting phases. The aim of this study is thermodynamic analysis of the two-dimensional phase coexistence in systems involving crystal-like free of defects layers in narrow slit pores. A special attention was paid to the determination of triple point temperatures. It is shown that intrinsic properties of argon monolayer adsorbed on the graphite surface are similar to those of isolated monolayer accommodated in the slit pore having width of two argon collision diameters. Analysis of the latter system is shown to be clearer and less time-consuming than the former one, which has allowed for explanation of the experimentally observed two-stage melting transition of argon monolayer on graphite without invoking the periodic surface potential modulation and orientational transition

  19. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.

    Levin, Aviad; Mason, Thomas O; Adler-Abramovich, Lihi; Buell, Alexander K; Meisl, George; Galvagnion, Celine; Bram, Yaron; Stratford, Samuel A; Dobson, Christopher M; Knowles, Tuomas P J; Gazit, Ehud

    2014-01-01

    The self-assembly of molecular building blocks into nano- and micro-scale supramolecular architectures has opened up new frontiers in polymer science. Such supramolecular species not only possess a rich set of dynamic features as a consequence of the non-covalent nature of their core interactions, but also afford unique structural characteristics. Although much is now known about the manner in which such structures adopt their morphologies and size distributions in response to external stimuli, the kinetic and thermodynamic driving forces that lead to their transformation from soluble monomeric species into ordered supramolecular entities have remained elusive. Here we focus on Boc-diphenylalanine, an archetypical example of a peptide with a high propensity towards supramolecular self-organization, and describe the pathway through which it forms a range of nano-assemblies with different structural characteristics. Our results reveal that the nucleation process is multi-step in nature and proceeds by Ostwald's step rule through which coalescence of soluble monomers leads to the formation of nanospheres, which then undergo ripening and structural conversions to form the final supramolecular assemblies. We characterize the structures and thermodynamics of the different phases involved in this process and reveal the intricate nature of the transitions that can occur between discrete structural states of this class of supramolecular polymers. PMID:25391268

  20. Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

    Levin, Aviad; Mason, Thomas O.; Adler-Abramovich, Lihi; Buell, Alexander K.; Meisl, George; Galvagnion, Celine; Bram, Yaron; Stratford, Samuel A.; Dobson, Christopher M.; Knowles, Tuomas P. J.; Gazit, Ehud

    2014-11-01

    The self-assembly of molecular building blocks into nano- and micro-scale supramolecular architectures has opened up new frontiers in polymer science. Such supramolecular species not only possess a rich set of dynamic features as a consequence of the non-covalent nature of their core interactions, but also afford unique structural characteristics. Although much is now known about the manner in which such structures adopt their morphologies and size distributions in response to external stimuli, the kinetic and thermodynamic driving forces that lead to their transformation from soluble monomeric species into ordered supramolecular entities have remained elusive. Here we focus on Boc-diphenylalanine, an archetypical example of a peptide with a high propensity towards supramolecular self-organization, and describe the pathway through which it forms a range of nano-assemblies with different structural characteristics. Our results reveal that the nucleation process is multi-step in nature and proceeds by Ostwald’s step rule through which coalescence of soluble monomers leads to the formation of nanospheres, which then undergo ripening and structural conversions to form the final supramolecular assemblies. We characterize the structures and thermodynamics of the different phases involved in this process and reveal the intricate nature of the transitions that can occur between discrete structural states of this class of supramolecular polymers.

  1. Steered molecular dynamics simulations of a type IV pilus probe initial stages of a force-induced conformational transition.

    Joseph L Baker

    2013-04-01

    Full Text Available Type IV pili are long, protein filaments built from a repeating subunit that protrudes from the surface of a wide variety of infectious bacteria. They are implicated in a vast array of functions, ranging from bacterial motility to microcolony formation to infection. One of the most well-studied type IV filaments is the gonococcal type IV pilus (GC-T4P from Neisseria gonorrhoeae, the causative agent of gonorrhea. Cryo-electron microscopy has been used to construct a model of this filament, offering insights into the structure of type IV pili. In addition, experiments have demonstrated that GC-T4P can withstand very large tension forces, and transition to a force-induced conformation. However, the details of force-generation, and the atomic-level characteristics of the force-induced conformation, are unknown. Here, steered molecular dynamics (SMD simulation was used to exert a force in silico on an 18 subunit segment of GC-T4P to address questions regarding the nature of the interactions that lead to the extraordinary strength of bacterial pili. SMD simulations revealed that the buried pilin α1 domains maintain hydrophobic contacts with one another within the core of the filament, leading to GC-T4P's structural stability. At the filament surface, gaps between pilin globular head domains in both the native and pulled states provide water accessible routes between the external environment and the interior of the filament, allowing water to access the pilin α1 domains as reported for VC-T4P in deuterium exchange experiments. Results were also compared to the experimentally observed force-induced conformation. In particular, an exposed amino acid sequence in the experimentally stretched filament was also found to become exposed during the SMD simulations, suggesting that initial stages of the force induced transition are well captured. Furthermore, a second sequence was shown to be initially hidden in the native filament and became exposed upon

  2. Navigated Early Survivorship Transition in Improving Survivorship Care Planning in Patients With Newly Diagnosed Stage I-III Breast, Lung, Prostate, or Colorectal Cancer and Their Caregivers

    2015-12-17

    Cancer Survivor; Caregiver; Stage I Colon Cancer; Stage I Lung Cancer; Stage I Prostate Cancer; Stage I Rectal Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Lung Cancer; Stage IIA Breast Cancer; Stage IIA Colon Cancer; Stage IIA Prostate Cancer; Stage IIA Rectal Cancer; Stage IIB Breast Cancer; Stage IIB Colon Cancer; Stage IIB Prostate Cancer; Stage IIB Rectal Cancer; Stage III Lung Cancer; Stage III Prostate Cancer; Stage IIIA Breast Cancer; Stage IIIA Colon Cancer; Stage IIIA Rectal Cancer; Stage IIIB Breast Cancer; Stage IIIB Colon Cancer; Stage IIIB Rectal Cancer; Stage IIIC Colon Cancer; Stage IIIC Rectal Cancer

  3. 1.2 V constant-gm rail-to-rail CMOS Op-Amp input stage with new overlapped transition regions technique for ECG amplifier.

    Lee, Boram; Higman, Ted

    2013-01-01

    The conventional technique of overlapped transition regions for producing a constant transconductance rail to rail Op-Amp input stage can only tolerate a limited amount of voltage shifting. This is limited by the minimum Vgs required for active mode operation of transistors. In this paper, we present a novel overlapped transition regions technique that overcomes the limitation of the conventional technique. This new overlapped transition regions technique has no voltage shifting limit. For both N-type and P-type conventional complementary differential input pairs, one source follower and one MOSFET are added to control the saturation point of current of input pairs. For 1.2 V single supply voltage, simulation results demonstrate ±3.71% of overall transconductance variation. Cadence SPECTRE simulator and TSMC 0.25-µm CMOS technology are used to layout and simulate this work. PMID:24110471

  4. Beyond the adoption/ non-adoption dichotomy: the impact of innovation characteristics on potential adopters' transition through adoption process stages

    Frambach, R T; Agarwal, M.K.; Nijssen, E.J.

    2002-01-01

    Research on innovation adoption has suffered from a bias towards understanding the factors that affect the dichotomous adoption/non-adoption decision. Much less attention is devoted to the question why potential adopters fail to progress to the adoption stage from earlier stages in the decision making process. Such knowledge is essential to understand what factors actually underlie the non-adoption of an innovation. As perceived innovation characteristics have been found to influence adoption...

  5. The Earliest Stage of Planet Formation: Disk-Planet Interactions in Protoplanetary Disks and Observations of Transitional Disks

    Dong, Ruobing; Rafikov, R.; Stone, J. M.; Hartmann, L. W.; SEEDS Team

    2013-01-01

    I will first talk about numerical simulations of disk-planet interactions in protoplanetary disks. Particularly, I’ll discuss the damping of the density waves excited by planets due to the nonlinearity in their propagation, which can result in gap opening in a low viscosity disk by low mass planets. I'll also discuss the effects of various numerical algorithms and parameters in simulations of disk-planet interaction, and address the question of how to produce correct simulations. Then I’ll move on to recent Subaru observations of transitional disks, which are protoplanetary disks with central depleted regions (cavities). Several ideas on the formation of transitional disks have been proposed, including gaps opened by planet(s). Recently, Subaru directly imaged a number of such disks at near infrared (NIR) wavelengths (the SEEDS project) with high spatial resolution and small inner working angles. Using radiative transfer simulations, we study the structure of transitional disks by modeling the NIR images, the SED, and the sub-mm observations from literature (whenever available) simultaneously. We obtain physical disk+cavity structures, and constrain the spatial distribution of the dust grains, particularly inside the cavity and at the cavity edge. Interestingly, we find that in some cases cavities are not present in the scattered light. In such cases we present a new transitional disk model to simultaneously account for all observations. Decoupling between the sub-um-sized and mm-sized grains inside the cavity is required, which may necessitate the dust filtration mechanism. For another group of transitional disks in which Subaru does reveal the cavities at NIR, we focus on whether grains at different sizes have the same spatial distribution or not. We use our modeling results to constrain transitional disk formation theories, particularly to comment on their possible planets origin.

  6. DROPOUT AND RETENTION RATE METHODOLOGY USED TO ESTIMATE FIRST-STAGE ELEMENTS OF THE TRANSITION PROBABILITY MATRICES FOR DYNAMOD II.

    HUDMAN, JOHN T.; ZABROWSKI, EDWARD K.

    EQUATIONS FOR SYSTEM INTAKE, DROPOUT, AND RETENTION RATE CALCULATIONS ARE DERIVED FOR ELEMENTARY SCHOOLS, SECONDARY SCHOOLS, AND COLLEGES. THE PROCEDURES DESCRIBED WERE FOLLOWED IN DEVELOPING ESTIMATES OF SELECTED ELEMENTS OF THE TRANSITION PROBABILITY MATRICES USED IN DYNAMOD II. THE PROBABILITY MATRIX CELLS ESTIMATED BY THE PROCEDURES DESCRIBED…

  7. Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio

    Gomes-Santos, Carina S. S.; Braks, Joanna; Prudêncio, Miguel; Carret, Céline; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; Khan, Shahid; Waters, Andrew; Janse, Chris,; Gunnar R. Mair; Mota, Maria M.

    2011-01-01

    Author Summary Injection of Plasmodium sporozoites by Anopheles mosquitoes into the human host initiates malaria infection. Generation of blood stage parasites leading to the onset of disease relies on the successful development of the sporozoite into merozoites in the liver. Here we show that in the rodent malaria model Plasmodium berghei these developmental transformations are controlled by the RNA binding protein Pumilio 2 (Puf2). In the absence of Puf2, sporozoites, while still in the mos...

  8. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio.

    Gomes-Santos, Carina S S; Braks, Joanna; Prudêncio, Miguel; Carret, Céline; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; Khan, Shahid; Waters, Andrew; Janse, Chris; Mair, Gunnar R; Mota, Maria M

    2011-05-01

    Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2) sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism. PMID:21625527

  9. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio

    Gomes-Santos, Carina S. S.

    2011-05-19

    Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2) sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism. 2011 Gomes-Santos et al.

  10. Transitional change in rat fetal cell proliferation in response to ghrelin and des-acyl ghrelin during the last stage of pregnancy

    Inoue, Yoshiyuki; Nakahara, Keiko [Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192 (Japan); Kangawa, Kenji [Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565 (Japan); Murakami, Noboru, E-mail: a0d201u@cc.miyazaki-u.ac.jp [Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192 (Japan)

    2010-03-12

    Expression of mRNA for the ghrelin receptor, GHS-R1a, was detected in various peripheral and central tissues of fetal rats, including skin, bone, heart, liver, gut, brain and spinal cord, on embryonic day (ED)15 and ED17. However, its expression in skin, bone, heart and liver, but not in gut, brain and spinal cord, became relatively weak on ED19 and disappeared after birth (ND2). Ghrelin and des-acyl ghrelin facilitated the proliferation of cultured fetal (ED17, 19), but not neonatal (ND2), skin cells. On the other hand, with regard to cells from the spinal cord and hypothalamus, the proliferative effect of ghrelin continued after birth, whereas the effect of des-acyl ghrelin on neurogenesis in these tissues was lost at the ED19 fetal and ND2 neonatal stages. Immunohistochemistry revealed that the cells in the hypothalamus induced to proliferate by ghrelin at the ND2 stage were positive for nestin and glial fibrillary acidic protein. These results suggest that in the period immediately prior to, and after birth, rat fetal cells showing proliferation in response to ghrelin and des-acyl ghrelin are at a transitional stage characterized by alteration of the expression of GHS-R1a and an undefined des-acyl ghrelin receptor, their responsiveness varying among different tissues.

  11. Structural characteristics of transition-iron-carbide precipitates formed during the first stage of tempering in 4340 steel

    Microstructural and crystallographic characteristics of fine-scale transition-iron-carbide precipitates formed in martensite during tempering of 4340 steel at 200 °C for 3.6 ks were studied via transmission electron microscopy. Precipitates of near-equiaxed shapes and about 10 nm in size were observed, and rows of closely spaced precipitates were aligned predominantly along < 100 > martensite directions. Aggregates of aligned precipitates were up to 150 nm in length, although occasional kinks were present that disrupted the alignment, and some of the adjacent precipitates possessed somewhat different crystallographic orientations. Electron-diffraction results were analyzed in detail and found to be consistent with both epsilon-carbide and eta-carbide phases. Similarities between these two phases were highlighted and discussed. Experimental electron-diffraction data were compared with data from five different unit cells, and each was found to be consistent within uncertainty ranges of ± 0.003 nm for interplanar spacings, ± 2° for angles between plane normals, and a few degrees for the orientation relationship between precipitates and the matrix

  12. FTIR/PCA study of propanol in argon matrix: the initial stage of clustering and conformational transitions

    FTIR spectra of 1-propanol in an argon matrix were studied in the range 11 to 30 K. Principal component analysis of dynamic FTIR spectra and nonlinear band shape fitting has been carried out. The peaks of monomer, open dimer, mixed propanol-water dimer and those of higher H-bond clusters have been resolved and analyzed. The attribution of certain FTIR peaks has been supported by proper density functional theory calculations. Analyzing dependences of the integral band intensities of various aggregates on temperature it has been deduced that in the initial stage of clustering monomers and dimers are the basic building blocks forming higher H-bond clusters. The peaks assigned to two conformers of monomers and mixed propanol-water dimers were investigated processing the temperature dependences of their integral intensities in Arrhenius plot. The obtained values of 0.18 kJ.mol-1 for propanol monomer and 0.26 kJ.mol-1 for mixed dimer are well comparable with the energy differences between the global minimum conformation of 1-propanol (Gt) and some other energetically higher structures (Tt or Tg).

  13. Evidence of a critical film thickness for the early growth stage transition in YBa2Cu3O7-δ thin films

    YBa2 Cu3 O7-δ thin films were grown by pulsed laser deposition on (100) SrTiO3 substrates with 0 and 5 deg. miscut angles along the [010] direction to observe and manipulate the growth at the early stages. For films on 0 deg miscut substrates, the first 30 A of growth was by island nucleation, and the areal density of nuclei increased with the film thickness. The transition from island nucleation to growth was between 30 and 60 A. Islands grew larger with the film thickness for films thicker than 30 A while the areal density was dramatically reduced. For the films on 5 deg. miscut substrates, the step-flow growth and island nucleation competed with each other for film thicknesses up to 30 A. When the film thickness increased above 60 A, the step-flow mode was dominant and no islands were observed. (author)

  14. Molecular candidates for early-stage flower-to-fruit transition in stenospermocarpic table grape (Vitis vinifera L.) inflorescences ascribed by differential transcriptome and metabolome profiles.

    Domingos, Sara; Fino, Joana; Paulo, Octávio S; Oliveira, Cristina M; Goulao, Luis F

    2016-03-01

    Flower-to-fruit transition depends of nutrient availability and regulation at the molecular level by sugar and hormone signalling crosstalk. However, in most species, the identities of fruit initiation regulators and their targets are largely unknown. To ascertain the main pathways involved in stenospermocarpic table grape fruit set, comprehensive transcriptional and metabolomic analyses were conducted specifically targeting the early phase of this developmental stage in 'Thompson Seedless'. The high-throughput analyses performed disclosed the involvement of 496 differentially expressed genes and 28 differently accumulated metabolites in the sampled inflorescences. Our data show broad transcriptome reprogramming of molecule transporters, globally down-regulating gene expression, and suggest that regulation of sugar- and hormone-mediated pathways determines the downstream activation of berry development. The most affected gene was the SWEET14 sugar transporter. Hormone-related transcription changes were observed associated with increased indole-3-acetic acid, stimulation of ethylene and gibberellin metabolisms and cytokinin degradation, and regulation of MADS-box and AP2-like ethylene-responsive transcription factor expression. Secondary metabolism, the most representative biological process at transcriptome level, was predominantly repressed. The results add to the knowledge of molecular events occurring in grapevine inflorescence fruit set and provide a list of candidates, paving the way for genetic manipulation aimed at model research and plant breeding. PMID:26810452

  15. Emittance Studies of the BNL/SLAC/UCLA 1.6 Cell Photocathode RF Gun

    Palmer, D.T.; /SLAC; Wang, X.J.; /Brookhaven; Miller, R.H.; /SLAC; Babzien, M.; Ben-Zvi, I.; /Brookhaven; Pellegrini, C.; /UCLA; Sheehan, J.; Skaritka, J.; /Brookhaven; Winick, H.; /SLAC; Woodle, M.; Yakimenko, V.; /Brookhaven

    2011-09-09

    The symmetrized 1.6 cell S-band photocathode gun developed by the BNL/SLAC/UCLA collaboration is in operation at the Brookhaven Accelerator Test Facility (ATF). A novel emittance compensation solenoid magnet has also been designed, built and is in operation at the ATF. These two subsystems form an emittance compensated photoinjector used for beam dynamics, advanced acceleration and free electron laser experiments at the ATF. The highest acceleration field achieved on the copper cathode is 150 MV/m, and the guns normal operating field is 130 MV/m. The maximum rf pulse length is 3 {mu}s. The transverse emittance of the photoelectron beam were measured for various injection parameters. The 1 nC emittance results are presented along with electron bunch length measurements that indicated that at above the 400 pC, space charge bunch lengthening is occurring. The thermal emittance, {epsilon}{sub o}, of the copper cathode has been measured.

  16. Microwave measurements of the BNL/SLAC/UCLA 1.6 cell photocathode rf gun

    The longitudinal accelerating field E. has been measured as a function of azimuthal angle in the full cell of the cold test model for the 1.6 cell BNL/SLAC/UCLA number-sign 3 S-band RF Gun using a needle rotation/frequency perturbation technique. These measurements were conducted before and after symmetrizing the full cell with a vacuum pump out port and an adjustable short. Two different waveguide to full cell coupling schemes were studied. The dipole mode of the full cell is an order of magnitude less severe before symmetrization for the 0θ-coupling scheme. The multi-pole contribution to the longitudinal field asymmetry are calculated using standard Fourier series techniques. The Panofsky-Wenzel theorem is used in estimating the transverse emittance due to the multipole components of Ex

  17. Altered snowfall and soil disturbance influence the early life stage transitions and recruitment of a native and invasive grass in a cold desert.

    Gornish, Elise S; Aanderud, Zachary T; Sheley, Roger L; Rinella, Mathew J; Svejcar, Tony; Englund, Suzanne D; James, Jeremy J

    2015-02-01

    Climate change effects on plants are expected to be primarily mediated through early life stage transitions. Snowfall variability, in particular, may have profound impacts on seedling recruitment, structuring plant populations and communities, especially in mid-latitude systems. These water-limited and frequently invaded environments experience tremendous variation in snowfall, and species in these systems must contend with harsh winter conditions and frequent disturbance. In this study, we examined the mechanisms driving the effects of snowpack depth and soil disturbance on the germination, emergence, and establishment of the native Pseudoroegnaria spicata and the invasive Bromus tectorum, two grass species that are widely distributed across the cold deserts of North America. The absence of snow in winter exposed seeds to an increased frequency and intensity of freeze-thaw cycles and greater fungal pathogen infection. A shallower snowpack promoted the formation of a frozen surface crust, reducing the emergence of both species (more so for P. spicata). Conversely, a deeper snowpack recharged the soil and improved seedling establishment of both species by creating higher and more stable levels of soil moisture availability following spring thaw. Across several snow treatments, experimental disturbance served to decrease the cumulative survival of both species. Furthermore, we observed that, regardless of snowpack treatment, most seed mortality (70-80%) occurred between seed germination and seedling emergence (November-March), suggesting that other wintertime factors or just winter conditions in general limited survival. Our results suggest that snowpack variation and legacy effects of the snowpack influence emergence and establishment but might not facilitate invasion of cold deserts. PMID:25539620

  18. The regional genomic instability induced by 60Co γ-rays in B16 cells transfected by GFP

    Objective: To detect the regional genomic instability of B16 cells treated with 60Co γ-rays by a green fluorescence protein (GFP)-based genomic instability reporting system. Methods: Three groups were employed as non-transfection group, vector control group and transfection group. The GFP-marked reporter construct pCMV-EGFP2XhoI for regional genomic instability was successfully transfected into B16 cells using liposome. B16 cells were selected by screening of G418 with a series of concentrations and limiting dilution cultures to yield a single colony. B16 cells with the genomic instability report system were then irradiated by 60Co γ-rays at doses of 0, 2 and 4 Gy. The regional genomic instability of B16 cells was quantified by counting the number of cells with GFP expression. Results: B-16 cell strain steadily expressing the GFP-based genomic instability reporting system was established successfully. GFP-positive B16 cells were observed at 1 d after irradiation with 60Co γ-rays at doses of 2 and 4 Gy. Positive correlations between fluorescence intensity and dose and fluorescence intensity and time were also observed. The positive expression rate of GFP followed the increased of dose (F=36.55, 36.76, P<0.05) and time (t=-3.27, -3.16, -4.26, -6.11, -7.17, P<0.05), and differences between groups were significant. The positive expression rate of GFP increased significantly at 3 d, and maximum expression was observed at 5 d (2.46 ± 0.24 and 3.82 ± 0.35). The level was tending towards stability. Spontaneous GFP expression at a ratio of 1/600000 was observed in 0 Gy group after 2 weeks of culture. Conclusions: The regional genomic instability of B16 cells induced by 60Co γ-rays can be detected using a GFP-labelled genomic instability reporter system. (authors)

  19. Palaeoenvironmental turnover across the Ypresian-Lutetian transition at the Agost section, Southastern Spain: In search of a marker event to define the Stratotype for the base of the Lutetian Stage

    Ortiz, S.; Gonzalvo, C.; Eustoquio, M.; Rodriguez-Tovar, F. J.; Uchman, A; Vandenberghe, N.; Zeelmaekers, E.

    2008-01-01

    Marker events to define the stratotype for the base of the Lutetian Stage are poorly defined. To elucidate such markers and characterize palaeoenvironmental turnovers, we conducted an integrated study of the Ypresian–Lutetian (Y–L; early-middle Eocene) transition at the continuous Agost section (southeastern Spain). This 115-m-thick section, which consists of hemipelagic marls intercalated with hemipelagic limestones and turbidity sandstones, spans from planktic foraminiferal Zones P9 to P12 ...

  20. Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells.

    Boulares, A H; Giardina, C; Inan, M S; Khairallah, E A; Cohen, S D

    2000-06-01

    A toxic dose of acetaminophen (APAP) reduces the activity of NF-kappaB in mouse liver. NF-kappaB inactivation may be important for APAP toxicity, as this transcription factor can play a central role in maintaining hepatic viability. We recently reported that APAP likewise inhibits serum growth factor activation of NF-kappaB in a mouse hepatoma cell line (Hepa 1-6 cells). Here we present evidence that APAP's antioxidant activity may be involved in this NF-kappaB inhibition in Hepa 1-6 cells. Like the antioxidants N-acetylcysteine (NAC) and pyrrolidinedithiocarbamate (PDTC), APAP was found to suppress the H(2)O(2)-induced oxidation of an intracellular reactive oxygen species probe (dihydrodichlorofluorescein) in Hepa 1-6 cells. Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events. The APAP inhibition of NF-kappaB activation by serum growth factors may also be due to APAP's antioxidant activity, as the antioxidants NAC and PDTC likewise inhibit this activation. The potential role of NF-kappaB and oxidant-based growth factor signal transduction in APAP toxicity is discussed. PMID:10828269

  1. Effect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells

    The effects of selenium compounds such as sodium selenite, sodium selenate, seleno-DL-cystine and seleno-DL-methionine (100 μM and 10 μM) on B16 and pigmented cloned pB 16 murine melanoma cells were investigated in vitro. At the tested concentrations, B16 cells showed a greater sensitivity to the toxic effects of sodium selenite and seleno-DL-cystine than pB 16 cells, whereas no decrease of B 16 and pB 16 cell number was observed after incubation with sodium selenate or seleno-DL-methionine. Glutathione (GSH) percentages were strongly decreased only by selenite and seleno-DL-cystine; it was marked more in B 16 than in pB 16 cells. The pretreatment of B 16 cells with a GSH depleting agent (10 μM buthionine-[S,R]-sulfoximine) did not significantly influence the cytotoxic effects of selenite and seleno-DL-cystine. On both cell populations. GSH preincubation (50 μM) enhanced the cytotoxicity of selenite whereas the survival of seleno-DL-cystine treated cells was increased. Glutathione peroxidase (GSH-Px) activity in B 16 cells was more sensitive than in pB 16 cells to the activating effect of selenite, and particularly of seleno-DL-cystine; however, cell-free controls indicated that activation was mainly due to glutathione reductase. The rate of 75Se (as sodium selenite) uptake in both cell populations was maximal within the first hour of incubation, with a preferential accumulation in the cytosol; after 24 h of incubation, the amount of 75Se in cytosol and pellet was approximately the same. Gel filtration chromatography of lysed cells after incubation for 6 h with 10 μM 75Se-selenite showed that the radioactivity was eluted as two peaks corresponding to low (4-9 kDa) and high (280-320 kDa) molecular weights. Possible toxicological mechanisms are discussed at molecular level. (orig./MG)

  2. The influence of the level of lamina propria invasion and the prevalence of p53 nuclear accumulation on survival in stage T1 transitional cell bladder cancer

    Hermann, G G; Horn, T; Steven, K

    1998-01-01

    immunoreactivity was determined with antibody PAB 1801. RESULTS: The study comprised 143 patients including 31 (22%) with stage T1a disease, 60 (42%) with stage T1b and 52 (36%) with stage T1c. Mean patient age was 67 years (range 38 to 92) and mean followup was 4.7 years (range 2.4 to 9.7). Tumor grade related...... in stages T1b and T1c compared with T1a disease. Of the patients 115 were treated with transurethral resection alone and 28 underwent radical cystectomy. Overall survival was 60.1%. Age was the only independent predictor of survival in patients older than 75 years. For patients up to 75 years old survival...... patients with stage T1b disease, particularly those with tumors expressing p53 nuclear reactivity and with dysplasia in the random mucosal biopsies....

  3. AFSC/RACE/SAP/Long: Data from: A novel quantitative model of multiple discrete stage transitions applied to crustacean larval development

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set describes the holding temperatures and developmental stages of larvae of red and blue king crab (Paralithodes camtschaticus and P. platypus) reared to...

  4. Construction of Egr-IFN γ and it's expression in B16 cells induced by ionizing irradiation

    Mouse IFN γ cDNA was ligated to downstream of Egr-1 promoter to construct Egr-IFN γ plasmid. The recombined plasmids were transfected into B16 cells with liposome, then the expression of IFN γ after different doses of X-ray irradiation and the time course of expression were detected by ELISA. The results showed that the expression levels in experimental groups were higher than that in the control group obviously (p<0.01); 6h after 2 Gy X-ray irradiation, the expression of IFN γ was highest (p<0.01); The B16 cells transfected were given 2 Gy X-ray irradiation every 24h, the expression level was highest after first irradiation (p<0.01) and then decrease gradually. The results indicated that ionizing irradiation can activate the Egr-IFN γ recombined plasmid and regulate the expression of IFN γ gene in B16 cells. The observation may be of potential significance in tumor therapy

  5. Observed degradation stages of ring-mold craters (RMC): Geomorphic evidence for modification of ice-rich deposits in the transitions zone between Elysium and Utopia Basin, Mars

    Pedersen, Gro Birkefeldt Møller

    Deposits with pits, depressions and RMCs observed north of Elysium rise are interpreted as degraded mixtures of ice and clastic material (CCF, LVF and LDA). Degradation stages of RMCs are an important tool for mapping dusty, deflated ice-rich units....

  6. The "Romsas in Motion" Community Intervention: Mediating Effects of Psychosocial Factors on Forward Transition in the Stages of Change in Physical Activity

    Lorentzen, Catherine; Ommundsen, Yngvar; Jenum, Anne Karen; Holme, Ingar

    2009-01-01

    This study examines whether a community-based physical activity intervention influenced movement in stages of change in physical activity in an adult population, whether any such effect was mediated by psychosocial influences, and whether any such mediations were moderated by sociodemographic or anthropometric factors. The 3-year-long…

  7. Staging Mobilities

    Jensen, Ole B.

    lived as people are “staging themselves” (from below). Staging mobilities is a dynamic process between “being staged” (for example, being stopped at traffic lights) and the “mobile staging” of interacting individuals (negotiating a passage on the pavement). Staging Mobilities is about the fact that...

  8. A Three-section Algorithm of Dynamic Programming Based on Three-stage Decomposition System Model for Grade Transition Trajectory Optimization Problems

    Yujie Wei; Yongheng Jiang; Dexian Huang⁎

    2014-01-01

    This paper introduces a practical solving scheme of gradetransition trajectory optimization (GTTO) problems under typical certificate-checking–updating framework. Due to complicated kinetics of polymerization, differential/algebraic equations (DAEs) always cause great computational burden and system non-linearity usual y makes GTTO non-convex bearing multiple optima. Therefore, coupled with the three-stage decomposi-tion model, a three-section algorithm of dynamic programming (TSDP) is proposed based on the general iteration mechanism of iterative programming (IDP) and incorporated with adaptivegrid allocation scheme and heuristic modifications. The algorithm iteratively performs dynamic programming with heuristic modifications under constant calculation loads and adaptively allocates the valued computational resources to the regions that can further improve the optimality under the guidance of local error estimates. TSDP is finally compared with IDP and interior point method (IP) to verify its efficiency of computation.

  9. Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.

    Kai, Hisahiro; Baba, Masaki; Okuyama, Toru

    2008-12-01

    We compared the inhibitory effects on melanogenesis of six plant parts (leaves, stems, roots, whole fruits, calyxes, and fruits without calyxes) of Cucumis sativus. MeOH extracts of leaves and stems inhibited melanin production in B16 cells. These extracts did not affect the activity of mushroom tyrosinase or crude enzyme lysate from B16 cells. However, the extracts decreased tyrosinase expression at the protein level. These results suggest that the depigmenting mechanism of extracts from leaves and stems of C. SATIVUS involves the expression of tyrosinase. Of eight compounds isolated from the leaves, lutein ( 1) (IC (50) = 170.7 microM) and (+)-(1 R,2 S,5 R,6 S)-2,6-di-(4'-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane ( 2) (IC (50) = 270.8 microM) were found to suppress melanogenesis. Whereas 1 was found to markedly decrease the expression levels of tyrosinase, 2 only weakly reduced tyrosinase expression. This suggests that 1 is an active component in the leaves of C. sativus and is a potentially useful skin-whitening agent. PMID:19009501

  10. Trading stages

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim;

    2012-01-01

    Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied ...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  11. Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation.

    Gessner, D K; Schlegel, G; Keller, J; Schwarz, F J; Ringseis, R; Eder, K

    2013-02-01

    factor responsible for upregulation of those genes in the liver during early lactation. In conclusion, this study provides additional evidence that the periparturient phase in dairy cows is associated with a proinflammatory condition in the liver. Moreover, it is shown for the first time that the transition from pregnancy to lactation leads to a strong upregulation of Nrf2 target genes with antioxidative or cytoprotective properties, which might be another physiologic means to prevent the liver against damage by the inflammation process and an increased generation of reactive oxygen species. PMID:23245956

  12. The influence of zero-mode on beam properties at 1.6 cell photocathode RF gun

    Recently, due to multi-bunch laser injection, it is worried that 0 mode, which is not considerable with single-bunch injection, could be excited by beam loading and would degrade the beam properties. Then, we evaluated the influence in a BNL/SLAC/UCLA 1.6 cell photocathode RF gun, which is made use of widely, by using particle tracking simulations. We assumed the charge in a bunch was 1 nC, and the frequency of the laser injection was the same as that of RF electric field (2856 MHz). As a result, the electric field of the 0 mode became larger and its phase changed by nearly 180deg compared with the case without beam loading. Hence, the influence of the 0 mode on the beam properties, i.e. energy spread, transverse emittance, and bunch length, showed the opposite behavior to the single-bunch injection scheme. The change in energy spread by 0 mode at 10deg laser injection phase was about -20% without beam loading and +40% with beam loading. (author)

  13. Development of brazing technique for a 1.6 cell BNL/SLAC/UCLA type photocathode guns by hydrogen brazing

    Two prototypes of a 1.6 cell BNL/SLAC/UCLA type RF photocathode gun, a precision machined RF structure capable of supporting gradients in excess of 80 MV/m, have been successfully brazed and leak rates of 10-10 mbar l/s have been achieved. Brazing, is carried out in two steps in a hydrogen furnace, it involves joining of two RF cavities, 6 cylindrical ports, one rectangular waveguide and one seal plate. The cavities and waveguide are made of copper and the ports and seal plate are of stainless steel. Fixtures were designed and fabricated indigenously to maintain the required assembly tolerances during brazing. This was important for brazing of ports, two of which are brazed to one cavity at an angle of 22.50 at diametrically opposite locations, and the remaining four are brazed to the other cavity in mutually perpendicular orientations. All joints were brazed using copper-silver eutectic (72-28) alloy in foil and wire forms. This paper discusses the brazing requirement, design of fixtures, and the procedure adopted for brazing of the photocathode gun. The paper also discusses results of the tests carried out to qualify the brazed joints. (author)

  14. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.

    Dabbagh-Bazarbachi, Husam; Clergeaud, Gael; Quesada, Isabel M; Ortiz, Mayreli; O'Sullivan, Ciara K; Fernández-Larrea, Juan B

    2014-08-13

    Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane. To prove this hypothesis, herein, we have demonstrated the capacity of QCT and epigallocatechin-gallate to rapidly increase labile zinc in mouse hepatocarcinoma Hepa 1-6 cells as well as, for the first time, in liposomes. In order to confirm that the polyphenols transport zinc cations across the plasma membrane independently of plasma membrane zinc transporters, QCT, epigallocatechin-gallate, or clioquinol (CQ), alone and combined with zinc, were added to unilamellar dipalmitoylphosphocholine/cholesterol liposomes loaded with membrane-impermeant FluoZin-3. Only the combinations of the chelators with zinc triggered a rapid increase of FluoZin-3 fluorescence within the liposomes, thus demonstrating the ionophore action of QCT, epigallocatechin-gallate, and CQ on lipid membrane systems. The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions. PMID:25050823

  15. Staging atmospheres

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr

    2015-01-01

    . Nevertheless, people’s experience of the environment is sought manipulated in a variety of contexts, often without offering a less ‘true’ experience of a situation than if it had not been manipulated by people. In fact, orchestrations of space are often central to sociality, politics and aesthetics. This...... introduction seeks to outline how a number of scholars have addressed the relationship between staged atmospheres and experience, and thus highlight both the philosophical, social and political aspects of atmospheres...

  16. Paths of lateral gene transfer of lysyl-aminoacyl-tRNA synthetases with a unique evolutionary transition stage of prokaryotes coding for class I and II varieties by the same organisms

    Nussinov Ruth

    2006-03-01

    Full Text Available Abstract Background While the premise that lateral gene transfer (LGT is a dominant evolutionary force is still in considerable dispute, the case for widespread LGT in the family of aminoacyl-tRNA synthetases (aaRS is no longer contentious. aaRSs are ancient enzymes, guarding the fidelity of the genetic code. They are clustered in two structurally unrelated classes. Only lysine aminoacyl-tRNA synthetase (LysRS is found both as a class 1 and a class 2 enzyme (LysRS1-2. Remarkably, in several extant prokaryotes both classes of the enzyme coexist, a unique phenomenon that has yet to receive its due attention. Results We applied a phylogenetic approach for determining the extent and origin of LGT in prokaryotic LysRS. Reconstructing species trees for Archaea and Bacteria, and inferring that their last common ancestors encoded LysRS1 and LysRS2, respectively, we studied the gains and losses of both classes. A complex pattern of LGT events emerged. In specific groups of organisms LysRS1 was replaced by LysRS2 (and vice versa. In one occasion, within the alpha proteobacteria, a LysRS2 to LysRS1 LGT was followed by reversal to LysRS2. After establishing the most likely LGT paths, we studied the possible origins of the laterally transferred genes. To this end, we reconstructed LysRS gene trees and evaluated the likely origins of the laterally transferred genes. While the sources of LysRS1 LGTs were readily identified, those for LysRS2 remain, for now, uncertain. The replacement of one LysRS by another apparently transits through a stage simultaneously coding for both synthetases, probably conferring a selective advantage to the affected organisms. Conclusion The family of LysRSs features complex LGT events. The currently available data were sufficient for identifying unambiguously the origins of LysRS1 but not of LysRS2 gene transfers. A selective advantage is suggested to organisms encoding simultaneously LysRS1-2.

  17. Transition Planning

    Statfeld, Jenna L.

    2011-01-01

    Post-school transition is the movement of a child with disabilities from school to activities that occur after the completion of school. This paper provides information about: (1) post-school transition; (2) transition plan; (3) transition services; (4) transition planning; (5) vocational rehabilitation services; (6) services that are available…

  18. High Power Beam Test and Measurement of Emittance Evolution of a 1.6-Cell Photocathode RF Gun at Pohang Accelerator Laboratory

    Park, Jang-Ho; Park, Sung-Ju; Kim, Changbum; Parc, Yong-Woon; Hong, Ju-Ho; Huang, Jung-Yun; Xiang, Dao; Wang, Xijie; Ko, In Soo

    2007-04-01

    A Brookhaven National Laboratory (BNL) GUN-IV type photocathode rf gun has been fabricated to use in femtosecond electron diffraction (FED), femtosecond far infrared radiation (fs-FIR) facility, and X-ray free electron laser (XFEL) facilities at the Pohang Accelerator Laboratory (PAL). The gun consists of a 1.6-cell cavity with a copper cathode, a solenoid magnet, beam diagnostic components and auxiliary systems. We report here the measurement of the basic beam parameters which confirm a successful fabrication of the photocathode RF gun system. The emittance evolution is measured by an emittance meter and compared with the PARMELA simulation, which shows a good agreement.

  19. CT staging of renal pelvis tumor

    To assess the value of computed tomography (CT) in the preoperative staging of transitional cell carcinoma (TCC) of the renal pelvis. We retrospectively evaluated the CT TNM staging of 38 patients with TCC of the renal pelvis who had undergone preoperative abdominal CT examination between January 1990 and January 1998. In CT staging for differentiation between early-stage (T0-2) and advanced-stage disease (T3-T4), three criteria were used, namely the presence or obliteration of the renal sinus fat layer, the smoothness or irregularity of margin between the tumor and renal parenchyma, and the presence or absence of hydronephrosis proximal to the tumor. CT staging was performed by two genitourinary radiologists blinded to the pathologic results, and was compared with pathologic staging. Pathologic results revealed 19 cases of early stage disease (T0=8, T1=9, T2=2) and 19 of advanced stage (T3=12, T4=7). Overall CT staging accuracy was 82%(31/38) ; four cases were overstaged and three were understaged. In early-stage disease, sensitivity and specificity were 79%, and 84%, and in advanced stage disease were 83% and 80%. Three of four overstaged cases showed hydronephrosis proximal to the tumor. In the second CT staging, using proximal hydronephrosis of the tumor as a criterion for early-stage disease, the sensitivity and specificity of early-stage disease were 95% and 75%, respectively, and the specificity of advanced-stage disease was 95%. When hydronephrosis proximal to a tumor was considered to be a sign of early stage disease, the CT staging of renal pelvic TCC was highly accurate

  20. Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, and Urologic Cancers

    2016-07-12

    Healthy, no Evidence of Disease; Localized Transitional Cell Cancer of the Renal Pelvis and Ureter; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Psychosocial Effects of Cancer and Its Treatment; Recurrent Bladder Cancer; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Gastric Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Uterine Sarcoma; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Stage II Bladder Cancer; Stage II Renal Cell Cancer; Stage II Urethral Cancer; Stage IIA Cervical Cancer; Stage IIA Colon Cancer; Stage IIA Gastric Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Pancreatic Cancer; Stage IIA Rectal Cancer; Stage IIA Uterine Sarcoma; Stage IIB Cervical Cancer; Stage IIB Colon Cancer; Stage IIB Gastric Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Pancreatic Cancer; Stage IIB Rectal Cancer; Stage IIB Uterine Sarcoma; Stage IIC Colon Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Rectal Cancer; Stage III Bladder Cancer; Stage III Pancreatic Cancer; Stage III Renal Cell Cancer; Stage III Urethral Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colon Cancer; Stage IIIA Gastric Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Rectal Cancer; Stage IIIA Uterine Sarcoma; Stage IIIB Cervical Cancer; Stage IIIB Colon Cancer; Stage IIIB Gastric Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Rectal Cancer; Stage IIIB Uterine Sarcoma; Stage IIIC Colon Cancer; Stage IIIC Gastric Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IIIC Rectal

  1. Esophageal Cancer Staging

    Rice, Thomas W.

    2015-01-01

    Accurate staging of esophageal cancer is very important to achieving optimal treatment outcomes. The AJCC (American Joint Committee on Cancer) first published TNM esophageal cancer staging recommendations in the first edition of their staging manual in 1977. Thereafter, the staging of esophageal cancer was changed many times over the years. This article reviews the current status of staging of esophageal cancer.

  2. Staging in oesophageal cancer

    Plukker, J. Th. M.

    2006-01-01

    Accurate staging defines groups for stage-specific treatment, minimising inappropriate treatment. Application of dedicated staging methods - including 16-64 multidetector computed tomography (CT), endoscopic ultrasonography with fine-needle aspiration (EUS-FNA) and positron emission tomography (PET)

  3. Early-Stage Caregiving

    ... the Diagnosis Early-Stage Caregiving Middle-Stage Caregiving Late-Stage Caregiving Find your local Chapter Zip code: Search by state Get Weekly E-News Stay up-to-date on Alzheimer's treatments and care. First ...

  4. Prostate cancer staging

    ... this page: //medlineplus.gov/ency/patientinstructions/000397.htm Prostate cancer staging To use the sharing features on this ... trials you may be able to join How Prostate Cancer Staging is Done Initial staging is based on ...

  5. Ovarian Cancer Stage IIIC

    ... My Pictures Browse Search Quick Search Image Details Ovarian Cancer Stage IIIC View/Download: Small: 734x648 View Download Add to My Pictures Title: Ovarian Cancer Stage IIIC Description: Drawing of stage IIIC ...

  6. Ovarian Cancer Stage IV

    ... My Pictures Browse Search Quick Search Image Details Ovarian Cancer Stage IV View/Download: Small: 576x641 View Download Add to My Pictures Title: Ovarian Cancer Stage IV Description: Drawing of stage IV ...

  7. Beam dynamics enhancement due to accelerating field symmetrization in the BNL/SLAC/UCLA 1.6 cell S-band photocathode RF gun

    A 1.6 cell photocathode S-Band gun developed by the BNL/SLAC/UCLA collaboration is now in operation at the Brookhaven Accelerator Test Facility (ATF). One of the main features of this RF gun is the symmetrization of the RF coupling iris with an identical vacuum pumping port located in the full cell. The effects of the asymmetry caused by the RF coupling iris were experimentally investigated by positioning a metallic plunger at the back wall of the vacuum port iris. The higher order modes produced were studied using electron beamlets with 8-fold symmetry. The 8-fold beamlets were produced by masking the laser beam. These experimental results indicate that the integrated electrical center and the geometrical center of the gun are within 175 microm. Which is within the laser alignment tolerance of 250 microm

  8. Paclitaxel, Polyglutamate Paclitaxel, or Observation in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Peritoneal Cancer, or Fallopian Tube Cancer

    2016-03-17

    Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Mixed Epithelial Tumor; Ovarian Brenner Tumor; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

  9. Penurunan Aktivitas Tirosinase dan Jumlah Melanin oleh Fraksi Etil Asetat Buah Malaka (Phyllantus emblica pada Mouse Melanoma B16 Cell-Line

    Reti Hindritiani

    2013-06-01

    Full Text Available Melanin accumulation can lead to hyperpigmentation, and if it occurs on the face can cause psychosocial problem. Depigmenting agents derived from plants are increasingly utilized. Agents being developed have to be effective in inhibiting melanin synthesis and should not be toxic to melanocyte. This study aimed was to examine the effect of ethyl acetate fraction from Phyllanthus emblica (P. emblica fruit, also known as malaka fruit, towards melanine synthesis, which was measured from the melanin amount and tyrosinase activity, the key regulatory enzyme in melanin synthesis, spectrophotometrically towards melanocytes of mouse melanoma B16 cell-line. The cytotoxic effect towards melanocytes was measured with 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyl-tetrazolium bromide (MTT assay. This study was conducted on November−December 2009 in Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, South Korea. The result of this study showed that tyrosinase activity and melanin amount decreased in a dose-dependent manner towards various concentrations of ethyl acetate fraction of P. emblica fruit with inhibition concentration (IC 50=95.63 and 16.90 μg/mL, respectively and lethal dose (LD 50 concentration 106.64 μg/mL. In conclusion, ethyl acetate fraction of P. emblica fruit is a potential depigmenting agent, since it can reduce melanin synthesis by inhibition of tyrosinase activity.

  10. Breast cancer staging

    ... this page: //medlineplus.gov/ency/patientinstructions/000911.htm Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  11. Stages of Adolescence

    ... Español Text Size Email Print Share Stages of Adolescence Page Content Article Body Adolescence, these years from puberty to adulthood, may be roughly divided into three stages: early adolescence, generally ages eleven to fourteen; middle adolescence, ages ...

  12. Pancreatic Cancer Stage 3

    ... 3 Description: Stage III pancreatic cancer; drawing shows cancer in the pancreas, common hepatic artery, and portal vein. Also shown ... and superior mesenteric artery. Stage III pancreatic cancer. Cancer ... near the pancreas. These include the superior mesenteric artery, celiac axis, ...

  13. Staging of Lung Cancer

    ... which therapy (or therapies) should be used. Second, lung cancer staging tells how much your cancer has spread. Knowing ... your body. How good are these tests at staging lung cancer? If your biopsy finds cancer cells, this is ...

  14. Cervical Cancer Stage IVB

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, Medical Illustration Source: National Cancer Institute ...

  15. Seven Stages of Alzheimer's

    ... Find your chapter: search by state Home > Alzheimer's Disease > Stages Overview What Is Dementia? What Is Alzheimer's? Younger/Early Onset Facts and Figures Know the 10 Signs Stages Inside the Brain: ...

  16. Dynamic Stage Design

    Florian von Hofen[GER

    2013-01-01

    Concepts and methods for dynamic stage designs were introduced ranging from different ifelds of TV live shows, exhibitions and theatre performances, and a special emphasis was put on solution to the theatre stage design.

  17. Transition joint

    A transition joint is disclosed for joining together tubular pieces formed respectively from a low alloy or carbon steel and a high temperature alloy composition having substantially different characteristics such as coefficient of thermal expansion, the transition joint including a plurality of tubular parts interconnected with each other by means of friction weld joints formed at an angle of 900 to the axis of the transition joint, the tubular parts at opposite ends of the transition joint being selected to facilitate in situ welding to the low alloy or carbon steel and high temperature alloy respectively. This friction welded transition joint can be used whenever different tubular pieces need to be joined together so that the joint can withstand high temperatures, for instance in heat exchangers and the such like. (Auth.)

  18. Staging Bipolar Disorder.

    Vieta i Pascual, Eduard, 1963-; Reinares, M.; Rosa, A. R.

    2011-01-01

    The purpose of this study was to analyze the evidence supporting a staging model for bipolar disorder. The authors conducted an extensive Medline and Pubmed search of the published literature using a variety of search terms (staging, bipolar disorder, early intervention) to find relevant articles, which were reviewed in detail. Only recently specific proposals have been made to apply clinical staging to bipolar disorder. The staging model in bipolar disorder suggests a progression from prodro...

  19. Two-Stage Bandits

    Clayton, Murray K.; Witmer, Jeffrey A.

    1988-01-01

    Two stochastic processes, or "arms," that yield dichotomous responses are available for use in a two-stage decision problem. During the first stage, arms are chosen sequentially; the resulting observations are discounted by a fixed value $\\beta$. A single arm must be used in the second stage, in which observations are not discounted. The decision to end the first stage is based on the data obtained. Optimal strategies are considered in the presence of the random discount sequence that arises ...

  20. Beyond Erikson's Eight Stages.

    Whitney, Ruth

    1979-01-01

    Erik Erikson has described eight stages of the healthy personality. This essay offers a revised version of the eight stages. Although most individuals develop through the eight stages, each is personally unique because patterns of fluctuation between safety and growth differ from one individual to another. (Author)

  1. Staging Mobilities / Designing Mobilities

    Jensen, Ole B.

    2015-01-01

    people are ‘staging themselves’ (from below). Staging mobilities is a dynamic process between ‘being staged’ (for example, being stopped at traffic lights) and the ‘mobile staging’ of interacting individuals (negotiating a passage on the pavement). Staging mobilities is about the fact that mobility is...

  2. Cervical Cancer Stage IA

    ... historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : Small: 720x576 ... Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical cancer; drawing ...

  3. Wetting transitions

    When a liquid droplet is put onto a surface, two situations distinguishable by the contact angle may result. If the contact angle is zero, the droplet spreads across the surface, a situation referred to as complete wetting. On the other hand, if the contact angle is between 0 deg. and 180 deg., the droplet does not spread, a situation called partial wetting. A wetting transition is a surface phase transition from partial wetting to complete wetting. We review the key experimental findings on this transition, together with simple theoretical models that account for the experiments. The wetting transition is generally first order (discontinuous), implying a discontinuity in the first derivative of the surface free energy. In this case, if one measures the thickness of the adsorbed film beside the droplet, at the wetting transition a discontinuous jump in film thickness occurs from a microscopically thin to a thick film. We show that this can lead to the observation of metastable surface states and an accompanying hysteresis. The observed hysteresis poses, in turn, a number of questions concerning the nucleation of wetting films that we also consider here. In addition, we consider the equilibrium wetting film thickness that results from a competition between the long-range van der Waals forces and gravity. Finally, the first-order character of the wetting transition can lead to a similar transition even when the phase that does the wetting is not (yet) stable in the bulk. For such prewetting transitions, a discontinuous thin-to-thick film transition occurs off bulk coexistence. We show that, for the large variety of systems for which prewetting transitions have been observed, the behaviour is surprisingly uniform, and can be mapped onto a simple generic phase diagram. The second part of the review deals with the exceptions to the first-order nature of the wetting transition. Two different types of continuous or critical wetting transition have been reported, for which

  4. Phase transitions

    Solé, Ricard V

    2011-01-01

    Phase transitions--changes between different states of organization in a complex system--have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas. How might phase transitions shed light on important problems in biological and ecological complex systems? Exploring the origins and implications of sudden changes in nature and society, Phase Transitions examines different dynamical behaviors in a broad range of complex systems. Using a compelling set of examples, from gene networks and ant colonies to human language and the degradation o

  5. Observing river stages using unmanned aerial vehicles

    Niedzielski, Tomasz; Witek, Matylda; Spallek, Waldemar

    2016-08-01

    We elaborated a new method for observing water surface areas and river stages using unmanned aerial vehicles (UAVs). It is based on processing multitemporal five orthophotomaps produced from the UAV-taken visible light images of nine sites of the river, acquired with a sufficient overlap in each part. Water surface areas are calculated in the first place, and subsequently expressed as fractions of total areas of water-covered terrain at a given site of the river recorded on five dates. The logarithms of the fractions are later calculated, producing five samples, each consisted of nine elements. In order to detect statistically significant increments of water surface areas between two orthophotomaps, we apply the asymptotic and bootstrapped versions of the Student's t test, preceded by other tests that aim to check model assumptions. The procedure is applied to five orthophotomaps covering nine sites of the Ścinawka river (south-western (SW) Poland). The data have been acquired during the experimental campaign, at which flight settings were kept unchanged over nearly 3 years (2012-2014). We have found that it is possible to detect transitions between water surface areas associated with all characteristic water levels (low, mean, intermediate and high stages). In addition, we infer that the identified transitions hold for characteristic river stages as well. In the experiment we detected all increments of water level: (1) from low stages to mean, intermediate and high stages; (2) from mean stages to intermediate and high stages; and (3) from intermediate stages to high stages. Potential applications of the elaborated method include verification of hydrodynamic models and the associated predictions of high flows as well as monitoring water levels of rivers in ungauged basins.

  6. Staged electrostatic precipitator

    Miller, Stanley J.; Almlie, Jay C.; Zhuang, Ye

    2016-03-01

    A device includes a chamber having an air inlet and an air outlet. The device includes a plurality of stages including at least a first stage adjacent a second stage. The plurality of stages are disposed in the chamber and each stage has a plurality of discharge electrodes disposed in an interior region and is bounded by an upstream baffle on an end proximate the air inlet and bounded by a downstream baffle on an end proximate the air outlet. Each stage has at least one sidewall between the upstream baffle and the downstream baffle. The sidewall is configured as a collection electrode and has a plurality of apertures disposed along a length between the upstream baffle and the downstream baffle. The upstream baffle of the first stage is positioned in staggered alignment relative to the upstream baffle of the second stage and the downstream baffle of the first stage are positioned in staggered alignment relative to the downstream baffle of the second stage.

  7. The Institutional Foundations of China's Market Transition

    Yingyi Qian

    1999-01-01

    April 1999 This paper intends to properly account for China's two decades of market transition by examining its institutional foundations. The journey of transition is analyzed as a two-stage process. In the first stage (1978-93), the system was reformed to unleash the standard forces of incentives, hard budget constraints, and competition, but the underlying institutional forms and mechanisms are far from conventional: reforming government through regional decentralization; entry and expansi...

  8. Multiple stage railgun

    A multiple stage magnetic railgun accelerator for accelerating a projectile by movement of a plasma arc along the rails. The railgun is divided into a plurality of successive rail stages which are sequentially energized by separate energy sources as the projectile moves through the bore of the railgun. Propagation of energy from an energized rail stage back towards the breech end of the railgun can be prevented by connection of the energy sources to the rails through isolation diodes. Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails into electrically isolated rail sections. In such case means are used to extinguish the arc at the end of each energized stage and a fuse or laser device is used to initiate a new plasma arc in the next energized rail stage

  9. The other stage

    Anderson, Christopher Stephen Williamson

    2012-01-01

    An interactive electroacoustic music composition and solo mixed-media performance realized as an alternatively-staged one-night concert event. This project examines the tradition of staging live electronic music and the role of a solo computer music composer-performer. It is a four-movement interactive work with an appended generative music system performed solo within an alternative stage layout. It is derived from an interdisciplinary practice of combining electroacoustic music and electro...

  10. [The epidemiological transition in Chile].

    Albalá, C; Vio, F; Robledo, A; Icaza, G

    1993-12-01

    Aiming to describe the place that Chile has in the epidemiological transition, a descriptive study of the changes in demographic and epidemiological profiles of the country during the last 30 years is presented. The important decrease in general and child mortality rates, that has lead to an increase in life expectancy and ageing of the population, is emphasized. A 82% reduction in the proportion of deaths among less than one year old children and a 62% increase in mortality among people 65 years or older is observed. In agreement with these changes, non transmissible chronic diseases appear as the principal cause of mortality (65% of all deaths). However, regarding morbidity, an increase in digestive infectious and sexually transmitted diseases and a decrease in immuno-preventable diseases, excepting measles, is noted. It is concluded that, according to mortality, Chile is in a post transition stage, but there is persistence of some infectious diseases, typical of a pre-transition stage. PMID:8085073

  11. Monetary Policy Rules in Some Transition Economies

    Mohamed El-Hodiri; Bulat Mukhamediyev

    2014-01-01

    In this paper we examine the question of whither monetary rules or ad hoc monetary policies were followed during the early stages of transition and in response to the global financial crisis. We study Eastern European countries and thee CIS countries. We find that during the early of transition, both developed economies and economies in transition used the monetary base, as well as the interest rate, as the main tools for monetary policy. However, in response to the global cris...

  12. Multiple Stages 2

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations......Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  13. Stages of Melanoma

    ... melanoma cells. The disease is metastatic melanoma, not lung cancer. The method used to stage melanoma is based mainly on the thickness of the tumor and whether cancer has spread to lymph nodes or other parts of the body. The staging of melanoma depends on the following: The thickness ...

  14. The Analysis, Optimization, and Simulation of a Two-Stage Tandem Queueing Model with Hyperexponential Service Time at Second Stage

    Vedat Sağlam

    2015-01-01

    Full Text Available The aim of this paper is to analyze a tandem queueing model with two stages. The arrivals to the first stage are Poisson stream and the service time at this stage is exponential. There is no waiting room at first stage. The service time is hyperexponential and no waiting is allowed at second stage. The transition probabilities and loss probabilities of this model are obtained. In addition, the loss probability at second stage is optimized. Performance measures and the variance of the numbers of customers of this tandem queueing model are found. It is seen that the numbers of customers in first stage and second stage are dependent. Finally we have simulated this queueing model. For different values of parameters, exact values, simulated values, and optimal values of obtained performance measures of this model are numerically shown in tables and graphs.

  15. Transitional Shelter

    Shiozaki, Yoshimitsu; TANAKA, Yasuo; Hokugo, Akihiko; Bettencourt, Sofia

    2013-01-01

    Transitional shelter can play a crucial role in housing reconstruction following a mega disaster. Reconstruction of permanent housing cannot move forward until a number of complex issues are settled, such as relocation planning and removal of debris. Even after plans are agreed on and reconstruction begins, it may take several years for permanent housing to be completed. In this context, a...

  16. Geometric interpretation of phyllotaxis transition

    Okabe, Takuya

    2012-01-01

    The original problem of phyllotaxis was focused on the regular arrangements of leaves on mature stems represented by common fractions such as 1/2, 1/3, 2/5, 3/8, 5/13, etc. The phyllotaxis fraction is not fixed for each plant but it may undergo stepwise transitions during ontogeny, despite contrasting observation that the arrangement of leaf primordia at shoot apical meristems changes continuously. No explanation has been given so far for the mechanism of the phyllotaxis transition, excepting suggestion resorting to genetic programs operating at some specific stages. Here it is pointed out that varying length of the leaf trace acts as an important factor to control the transition by analyzing Larson's diagram of the procambial system of young cottonwood plants. The transition is interpreted as a necessary consequence of geometric constraints that the leaf traces cannot be fitted into a fractional pattern unless their length is shorter than the denominator times the internode.

  17. Prostate cancer staging

    ... effects of treatment The chance that treatment can cure your cancer or help you in other ways With stage ... III prostate cancer, the main goal is to cure the cancer by treating it and keeping it from coming ...

  18. Dynamical transition of heat transport in a physical gel near the sol-gel transition

    Kobayashi, Kazuya U.; Noriko Oikawa; Rei Kurita

    2015-01-01

    We experimentally study heat transport in a gelatin solution near a reversible sol-gel transition point where viscosity strongly depends on temperature. We visualize the temperature field and velocity field using thermochromic liquid crystals and polystyrene latex particles, respectively. During the initial stages of heating, we find that heat transport undergoes a dynamical transition from conductive to convective. Subsequently, during later stages, we observe that the transport dynamics are...

  19. Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy

    2016-02-09

    Lymphedema; Perioperative/Postoperative Complications; Stage IA Vulvar Cancer; Stage IB Vulvar Cancer; Stage II Vulvar Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVA Vulvar Cancer; Stage IVB Vulvar Cancer

  20. [Humanitarian transition].

    Mattei, Jean-François; Troit, Virginie

    2016-02-01

    In two centuries, modern humanitarian action has experienced several fractures often linked to crises. Although its professionalism and intervention force remain indisputable, it faces, since the 2000s, a new context that limits its ability to act and confronts it with new dilemmas, even though it must deal with needs for aid of unprecedented scale. These difficulties reveal a humanitarian transition period that was not anticipated. This transition period reflects the change from a dominant paradigm of North-South solidarity of Western origin to a much more complex model. This article provides a summary of the current mutations that are dominated by the States' assertion of sovereignty. Among the possible solutions, it argues for an ethical approach and a better integration of the research carried out in the Global South, prerequisites for building a true partnership and placing the victims at the heart of the operations which involve them. PMID:26936180

  1. Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

    2016-02-09

    Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

  2. Optical control of multi-stage thin film solar cell production

    Li, Jian; Levi, Dean H.; Contreras, Miguel A.; Scharf, John

    2016-05-17

    Embodiments include methods of depositing and controlling the deposition of a film in multiple stages. The disclosed deposition and deposition control methods include the optical monitoring of a deposition matrix to determine a time when at least one transition point occurs. In certain embodiments, the transition point or transition points are a stoichiometry point. Methods may also include controlling the length of time in which material is deposited during a deposition stage or controlling the amount of the first, second or subsequent materials deposited during any deposition stage in response to a determination of the time when a selected transition point occurs.

  3. Principles of Melanoma Staging.

    Boland, Genevieve M; Gershenwald, Jeffrey E

    2016-01-01

    Although now commonplace in contemporary cancer care, the systematic approach to classification of disease-specific cancers into a formalized staging system is a relatively modern concept. Overall, the goals of cancer staging are to characterize the status of cancer at a specific moment in time, risk stratify, facilitate prognostication, and inform clinical decision making. The revisions to the American Joint Committee on Cancer (AJCC) melanoma staging system over time reflect changes in our understanding of the biology of the disease. Since the 1st edition, where tumor thickness was defined anatomically by its relationship to the reticular or papillary dermis (Clark level) as well as tumor thickness (Breslow thickness), there have been significant strides in our use of clinicopathological variables to stratify low- versus high-risk patients. Management of the regional nodal basin has also changed dramatically over time, impacted by techniques such as lymphatic mapping and sentinel lymph node biopsy (SLNB) and changes in pathological evaluation of the regional lymph nodes. Additionally, stratification of distant metastases has evolved as survival outcomes have been shown to vary based upon anatomic site of metastases and serum lactate dehydrogenase levels. The variables in use in the current (7th edition) AJCC staging system are surrogate markers of biology with validated impact of survival outcomes. Going forward, it is likely that these and additional clinicopathological factors will be integrated with molecular and other correlates of melanoma tumor biology to further refine and personalize melanoma staging. PMID:26601861

  4. Staging of extrahepatic cholangiocarcinoma

    Preoperative staging of extrahepatic cholangiocarcinoma is important in determining the best treatment plan. Several classification systems have been suggested to determine the operability and extent of surgery. Longitudinal tumor extent is especially important in extrahepatic cholangiocarcinoma because operative methods differ depending on the tumor extent. The Bismuth-Corlette classification system provides useful information when planning for surgery. However, this classification system is not adequate for selecting surgical candidates. Anatomic variation of the bile duct and gross morphology of the tumor must be considered simultaneously. Lateral spread of the tumor can be evaluated based on the TNM staging provided by American Joint Committee on Cancer (AJCC). However, there is a potential for ambiguity in the distinction of T1 and T2 cancer from one another. In addition, T stage does not necessarily mean invasiveness. Blumgart T staging is helpful for the assessment of resectability with the consideration of nodal status and distant metastasis as suggested by the AJCC cancer staging system. Computed tomography (CT) and magnetic resonance imaging (MRI) are the primary tools used in the assessment of longitudinal and lateral spread of a tumor when determining respectability. Diagnostic laparoscopy and positron emission tomography (PET) may play additional roles in this regard. (orig.)

  5. New School Stages for Old.

    Miller, James Hull

    A new and dynamic approach to auditorium stage design is presented. Contents include--(1) modified proscenium stage plan--a definition, (2) benefits of a modified proscenium stage plan, and (3) details of a modified proscenium stage plan--basic concepts, a typical layout, projection systems, and scenic design for space stage. (RH)

  6. Transit space

    Raahauge, Kirsten Marie

    2008-01-01

    This article deals with representations of one specific city, Århus, Denmark, especially its central district. The analysis is based on anthropological fieldwork conducted in Skåde Bakker and Fedet, two well-off neighborhoods. The overall purpose of the project is to study perceptions of space...... and the interaction of cultural, social, and spatial organizations, as seen from the point of view of people living in Skåde Bakker and Fedet. The focus is on the city dwellers’ representations of the central district of Århus with specific reference to the concept of transit space. When applied to various Århusian...

  7. Composers on stage

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs...... to rise the following questions: What happens to the status of the author, when he suddenly (re-)appears on stage? How is this appearance to be understood in both a contemporary and historical context: Is it the musical virtuous appearing again, are we witnessing musical works turning...... Rønsholdt’s Documentary Concert (2013) and Johannes Kreidler Fremdarbeit (2009)....

  8. Staging interrail mobilities

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.

    2016-01-01

    This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous stud...

  9. World Stage Design

    2005-01-01

    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  10. Stages of Pregnancy

    ... Know your pregnancy rights Getting ready for baby Childbirth and beyond Mom-to-be tools Government in action on pregnancy Pregnancy in Spanish ( en español ) Subscribe to Stages of pregnancy email updates. Enter email address Submit Home > Pregnancy > You're pregnant: Now what? Pregnancy This ...

  11. Pancreatic Cancer Stage 4

    ... lung, liver, and peritoneal cavity. An inset shows cancer cells spreading from the pancreas, through the blood and lymph system, to another ... abdomen that contains the intestines, stomach, and liver). Cancer may also have spread to ... pancreas or to lymph nodes. Stage IV pancreatic cancer. ...

  12. Stages of economic growth

    Kejak, Michal

    Detroit : Macmillan Reference USA, 2008 - (Darity, W.), s. 79-82 ISBN 978-0-02-865973-2. - (International encyclopedia of the social sciences. Vol. 8) R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : economic growth * stages * political consequencies Subject RIV: AH - Economics

  13. Multi-stage magnetic induction mass accelerator

    The magnetic induction method of mass acceleration readily lends itself to multi-staging. In the limit of many stages, such an accelerator approaches a distributed energy source system where only closing switches are necessary. We describe the design and performance of a three-stage accelerator, each driven by a separate capacitor bank. This system was modeled using a previously reported computer code. In order to do this the code was modified to calculate projectile acceleration through a succession of driver coils: Thermal conductivity and surface melting models were also added. The former is necessary due to the extended transit time through many stages. The latter is needed in anticipation of the more extreme ohmic heating when the capacitor banks are replaced by explosive-driven, magnetic flux compression generators. The performance goal of this system is to at least double the kinetic energy of a 0.3 kgm copperclad, steel projectile injected at a velocity of 300 m/sec from an explosive-driven gun. We then plan to test the system at the thermal and mechanical limit by using explosive-driven, magnetic flux compression generators as energy sources. We envision a six-stage system driven by three generators

  14. An Observational Perspective of Transitional Disks

    Espaillat, Catherine; Najita, Joan; Andrews, Sean; Zhu, Zhaohuan; Calvet, Nuria; Kraus, Stefan; Hashimoto, Jun; Kraus, Adam; D'Alessio, Paola

    2014-01-01

    Transitional disks are objects whose inner disk regions have undergone substantial clearing. The Spitzer Space Telescope produced detailed spectral energy distributions (SEDs) of transitional disks that allowed us to infer their radial dust disk structure in some detail, revealing the diversity of this class of disks. The growing sample of transitional disks also opened up the possibility of demographic studies, which provided unique insights. There now exist (sub)millimeter and infrared images that confirm the presence of large clearings of dust in transitional disks. In addition, protoplanet candidates have been detected within some of these clearings. Transitional disks are thought to be a strong link to planet formation around young stars and are a key area to study if further progress is to be made on understanding the initial stages of planet formation. Here we provide a review and synthesis of transitional disk observations to date with the aim of providing timely direction to the field, which is about...

  15. Sustainable Transition

    Hansen, Ole Erik; Søndergård, Bent

    2014-01-01

    agendas/vision, technologies, actors and institutions in the emergent design of an urban mobility system based on an electric car sharing system. Why. Designing for sustainability is a fundamental challenge for future design practices; designers have to obtain an ability to contribute to sustainable......What. The chapter addresses designing for sustainability as interventions in socio-technical systems and social practices of users and communities. It calls for reflexive design practices challenging dominant regimes and shaping alternative design spaces. The specific case is the reconfiguration of...... including the perspective of structural changes (transition of socio-technical systems and social practices) and Design as metadesign; an reflexivity on contextual framework of the design practice (regimes/design spaces)....

  16. Habitat Fragmentation Drives Plant Community Assembly Processes across Life Stages

    Hu, Guang; Feeley, Kenneth J.; Yu, Mingjian

    2016-01-01

    Habitat fragmentation is one of the principal causes of biodiversity loss and hence understanding its impacts on community assembly and disassembly is an important topic in ecology. We studied the relationships between fragmentation and community assembly processes in the land-bridge island system of Thousand Island Lake in East China. We focused on the changes in species diversity and phylogenetic diversity that occurred between life stages of woody plants growing on these islands. The observed diversities were compared with the expected diversities from random null models to characterize assembly processes. Regression tree analysis was used to illustrate the relationships between island attributes and community assembly processes. We found that different assembly processes predominate in the seedlings-to-saplings life-stage transition (SS) vs. the saplings-to-trees transition (ST). Island area was the main attribute driving the assembly process in SS. In ST, island isolation was more important. Within a fragmented landscape, the factors driving community assembly processes were found to differ between life stage transitions. Environmental filtering had a strong effect on the seedlings-to-saplings life-stage transition. Habitat isolation and dispersal limitation influenced all plant life stages, but had a weaker effect on communities than area. These findings add to our understanding of the processes driving community assembly and species coexistence in the context of pervasive and widespread habitat loss and fragmentation. PMID:27427960

  17. Painting Tableau Stage

    Derby, Moyra; Elliot, Stuart; Finch, Mark; Harland, Beth

    2013-01-01

    The central visual core of Painting Tableau Stage comprised of paintings by four contemporary artists from the United Kingdom, Moyra Derby, Stuart Elliot, Mick Finch, Beth Harland, all of whom share an interest in concepts of the tableau, a term that has received recent critical attention in the U.K. and often translated as "picture form." In addition, a small selection of scenographic artifacts and models from OSU's Jerome Lawrence and Robert E. Lee Theater Research Institute act as a visual...

  18. Endometrial carcinoma stage I.

    Baram, A; Ron, I; Kupferminc, M; Inbar, M

    1997-01-01

    Standard staging and therapeutic approach to endometrial cancer involves lymph node sampling (LNS) at the time of total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO). Lymphadenectomy prolongs time of surgery and increases the risk of morbidity; where other predictors are available, it may not contribute important supplementary information. 185/247 women with stage I endometrial carcinoma underwent the standard surgery while 62 underwent TAH+BSO. Recurrence and survival were monitored for a mean of 6.5 years and retrospectively reviewed: the rates for groups with and without known lymph node status were alike [13.5% (25/185) recurrence for the former and 12.9% (8/62) for the latter, and 5-year survival rates of 75.7% (140/185) for the former and 74.2 (46/62) for the latter]. Myometrial invasion and histological grade appeared to have been highly accurate predictors without lymph node information. Because information on histological grade is available early and is highly predictive, its use could be incorporated into a revised management algorithm for stage I endometrial cancer which would depend upon ensuring lymphadenectomy for women with low grade histopathology and omitting it for those with high grades on the grounds that no further information is necessary to act appropriately. PMID:21590195

  19. Staging Sociotechnical Spaces

    Clausen, Christian; Yoshinaka, Yutaka

    2007-01-01

    The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and politic...... of product development. The concept of socio-technical spaces is further illustrated through actual examples from industry dealing with early conceptualisation in product development and the role played by management concepts in the configuration of spaces.......The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and political...... process theory may contribute to a reflexive understanding of design as the staging of socio-technical relations and processes cutting across boundaries of diverse organisational, political and knowledge domains. This idea is pursued through the notion of ‘socio-technical spaces’. Socio-technical space...

  20. Stages: A system for generating strategic alternaties for forest management.

    Bos, J.

    1994-01-01

    Strategic planning is important in forest management. However, it has never been described clearly in literature. In this study a framework for strategic planning was developed and based on this a STrategic Alternatives Generating System (STAGES) to support decision making in strategic planning for forest management. This strategic planning consists of deciding on zoning, future forest and transition management. STAGES consists of a zoning model (which addresses the zoning decision problem th...

  1. Transitions in Theory and Practice: Managing Metals in the Circular Economy

    Melissa Jackson; Aleta Lederwasch; Damien Giurco

    2014-01-01

    Transitioning from current resource management practice dominated by linear economic models of consumption and production, to circular models of resource use, will require insights into the stages and processes associated with socio-technical transitions. This paper is concerned with transitions in practice. It explores two frameworks within the transitions literature—the multi-level perspective and transition management theory—for practical guidance to inform a deliberate transition in pract...

  2. Transition time

    Carlos Renato Zacharias

    2013-03-01

    Full Text Available 2013 is going to be an interesting year for the High Dilution research field. There is a tendency to revise basic concepts and common beliefs, while refining models and theories. The fundamental research team seems to be open to deeper discussions, aiming to reinforce some hypothesis and discharge others. In somehow, we are stuck in a vicious way of think, trying to manage and describe an informational phenomenon into a molecular framework. The challenge offered to those researchers involved with basic science is to figure out how to deal with such phenomenon, since previous theories and models have not shown to be matched! In the other hand, there is a tendency to explore the HD phenomenon in its technological branch. While basic research is important to describe how things work, the applied research has a more intense social and economic appeal. To develop technology based on HD means to give a different kind of visibility to the field, attracting sponsors, companies, entrepreneurs, always committed to the market regulatory laws. I am expecting for this year some important movements, both in the basic and applied research. Of course, it will be only a new beginning, as these changes require a lot of work, discussions and insights. But this transition time is very welcome!

  3. Characterization and endocytic internalization of Epith-2 cell surface glycoprotein during the epithelial-to-mesenchymal transition in sea urchin embryos

    HidekiKatow

    2013-08-01

    Full Text Available The epithelial cells of the sea urchin Hemicentrotus pulcherrimus embryo express an Epith-2, uncharacterized glycoprotein, on the lateral surface. Here, we describe internalization of Epith-2 during mesenchyme formation through the epithelial-to-mesenchymal transition (EMT. Epith-2 was first expressed on the entire egg surface soon after fertilization and on the blastomeres until the 4-cell stage, but was localized to the lateral surface of epithelial cells at and after the 16-cell stage throughout the later developmental period. However, primary (PMC and secondary mesenchyme cells (SMC that ingress by EMT lost Epith-2 from their cell surface by endocytosis during dissociation from the epithelium, which was associated with the appearance of cytoplasmic Epith-2 dots. The cytoplasmic Epith-2 retained a similar relative molecular mass to that of the cell surface immediately after ingression through the early period of the spreading to single cells. Then, Epith-2 was completely lost from the cytoplasm. Tyrosine residues of Epith-2 were phosphorylated. The endocytic retraction of Epith-2 was inhibited by herbimycin A (HA, a protein tyrosine kinase (PTK inhibitor, and suramin, a growth factor receptor (GFR inhibitor, suggesting the involvement of the GFR/PTK (GP signaling pathway. These two GP inhibitors also inhibited PMC and SMC spreading to individual cells after ingression, but the dissociation of PMC and SMC from the epithelium was not inhibited. In suramin-treated embryos, dissociated mesenchyme cells migrated partially by retaining their epithelial morphology. In HA-treated embryos, no mesenchyme cells migrated. Thus, the EMT occurs in relation to internalization of Epith-2 from presumptive PMC and SMC.

  4. Nuclear Cryogenic Propulsion Stage

    Houts, Michael G.; Borowski, S. K.; George, J. A.; Kim, T.; Emrich, W. J.; Hickman, R. R.; Broadway, J. W.; Gerrish, H. P.; Adams, R. B.

    2012-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced NEP.

  5. Stagings of Divine Power

    Holm, Bent

    2011-01-01

    Based on a combination of performativity and historicity royal Danish ceremonilality is analysed with a special regard to coronation ceremonies as a manifestation of the idea of godgiven royal power. Point of departure is the coronation of Christian 4. in 1596 and the theme of stagings of power...... is investigated up to the 18. century. Particilarly three fields of reference are exposed - the Christian, the Antique, and the Norse - in a context of European notions and manifestations of royal and state power. Three approaches are especially significant: Divine Monarchy, Divine Monarch, The long Baroque....

  6. Metropolitanization:China’s Transitioning Urbanization Patterns

    2010-01-01

    Amid larger institutional transitions,China has seen rapid urbanization stimulated by the marketization and new industrialization in the country.Now facing a series of new challenges,the traditional mode of urbanization needs to be changed.History has proven that metropolitanization is a necessary stage of urban development;under the circumstances of China’s current industrialization,metropolitanization emerges as the primary direction in China’s transitioning urbanization.This paper suggests certain measures for boosting metropolitanization and urbanization transition in China.

  7. Global transition in health.

    Bygbjerg, Ib Christian; Meyrowitsch, Dan W

    2007-02-01

    backwards upon the three stages of Omran's original thesis on epidemiological transition, to understand life and death forwards, in a world in fast transition, cf. the Danish philosopher Soeren Kirkegaard: "it is true what philosophy tells us, that life must be understood backwards, while not forgetting the second sentence, that it must be lived forwards". PMID:17349223

  8. Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy

    2016-02-09

    Cognitive Side Effects of Cancer Therapy; Malignant Ovarian Epithelial Tumor; Malignant Ovarian Mixed Epithelial Tumor; Ovarian Brenner Tumor; Ovarian Carcinosarcoma; Ovarian Choriocarcinoma; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Dysgerminoma; Ovarian Embryonal Carcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Mucinous Cystadenocarcinoma; Ovarian Polyembryoma; Ovarian Sarcoma; Ovarian Serous Cystadenocarcinoma; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IA Ovarian Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Cancer; Stage IC Ovarian Germ Cell Tumor; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Primary Peritoneal Cancer; Undifferentiated Ovarian Carcinoma

  9. Transitions: A Personal Perspective.

    Wood, Ann Stace

    1995-01-01

    Distinguishes between unchosen transitions (children maturing and leaving, parents aging, companies downsizing) and chosen ones (moving, divorce, marriage, career changes). Describes the steps one goes through: uneasiness, renewed energy, complaining, exploration, partial transition, and the completed transition. (JOW)

  10. Transition to Adulthood

    ... Parent Center PTACs Workspaces Log-in Search for: Transition to Adulthood Link-checked, June 2016 A legacy ... Resources of more info _________________________ A Quick Summary of Transition Transition services are intended to prepare students to ...

  11. CT staging of renal cell carcinoma

    Objective: To assess the usefulness of computerized tomography (CT) in the characterization of renal masses, in order to stage them, determine their prognosis and their appropriate clinical and/or surgical management. Material and Methods: Between 1988 and 2001, we selected 63 patients with renal tumors that had been examined by pathology. Patient's ages ranged from 16 to 88 years (25 women, 38 men). The studies were performed with a sequential helical CT, using 5 mm thickness sections every 5mm evaluating the cortico medullar and nephrographic phases. Renal tumors were characterized and staged without any knowledge about the pathological findings; subsequently the tomographic characteristics were compared to such findings. The following characteristics were evaluated: 1) mixed solid-cystic nature; 2) size; 3) borders; 4) enhancement; 5) necrosis; 6) hemorrhage; 7) central scar; 8) presence of fat; 9) collecting system; 10) capsular invasion; 11) perirenal fat invasion; 12) vessels; 13) Gerota's fascia; 14) lymph nodes; and 15) local and/or distant metastases. Results: Of the 63 tumors, 2 were complicated cysts; of the 61 remaining tumors, 10 were angiomyolipomas, 1 was a renal lymphoma, 1 was a focal xantogranulomatose pyelonephritis, 1 was a metanephric adenoma, 3 papillary renal cell carcinoma (RCC), 4 transitional cell tumors, 4 oncocytomas, 37 clear cell renal carcinoma. The CT could correctly characterize the 2 cystic tumors as such, as well as the 9 angiomyolipomas and the 4 transitional cell tumors. The 48 other tumors (1 angiomyolipoma, 1 lymphoma, 1 focal xantogranulomatose pyelonephritis, 1 metanephric adenoma, 3 papillary RCC, 4 oncocytomas, and 37 cell renal carcinomas) remaining were characterized as renal adenocarcinomas and CT staged. Conclusion: CT is a useful method to characterize renal masses since it determines their solid-cystic or fatty structure; aiding in many cases to define a surgical treatment. For the CT staging of renal tumors, the

  12. Pancreatic Cancer Stage 2A

    ... 2A Description: Stage IIA pancreatic cancer; drawing shows cancer in the pancreas and duodenum. The bile duct and pancreatic duct are also shown. Stage IIA pancreatic cancer. Cancer has spread to nearby tissue and organs ...

  13. Pancreatic Cancer Stage 2B

    ... 2B Description: Stage IIB pancreatic cancer; drawing shows cancer in the pancreas and in nearby lymph nodes. Also shown are the bile duct, pancreatic duct, and duodenum. Stage IIB pancreatic cancer. Cancer has spread to nearby lymph nodes and ...

  14. PREDICTING TURBINE STAGE PERFORMANCE

    Boyle, R. J.

    1994-01-01

    This program was developed to predict turbine stage performance taking into account the effects of complex passage geometries. The method uses a quasi-3D inviscid-flow analysis iteratively coupled to calculated losses so that changes in losses result in changes in the flow distribution. In this manner the effects of both the geometry on the flow distribution and the flow distribution on losses are accounted for. The flow may be subsonic or shock-free transonic. The blade row may be fixed or rotating, and the blades may be twisted and leaned. This program has been applied to axial and radial turbines, and is helpful in the analysis of mixed flow machines. This program is a combination of the flow analysis programs MERIDL and TSONIC coupled to the boundary layer program BLAYER. The subsonic flow solution is obtained by a finite difference, stream function analysis. Transonic blade-to-blade solutions are obtained using information from the finite difference, stream function solution with a reduced flow factor. Upstream and downstream flow variables may vary from hub to shroud and provision is made to correct for loss of stagnation pressure. Boundary layer analyses are made to determine profile and end-wall friction losses. Empirical loss models are used to account for incidence, secondary flow, disc windage, and clearance losses. The total losses are then used to calculate stator, rotor, and stage efficiency. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370/3033 under TSS with a central memory requirement of approximately 4.5 Megs of 8 bit bytes. This program was developed in 1985.

  15. A three-stage model of Golgi structure and function.

    Day, Kasey J; Staehelin, L Andrew; Glick, Benjamin S

    2013-09-01

    The Golgi apparatus contains multiple classes of cisternae that differ in structure, composition, and function, but there is no consensus about the number and definition of these classes. A useful way to classify Golgi cisternae is according to the trafficking pathways by which the cisternae import and export components. By this criterion, we propose that Golgi cisternae can be divided into three classes that correspond to functional stages of maturation. First, cisternae at the cisternal assembly stage receive COPII vesicles from the ER and recycle components to the ER in COPI vesicles. At this stage, new cisternae are generated. Second, cisternae at the carbohydrate synthesis stage exchange material with one another via COPI vesicles. At this stage, most of the glycosylation and polysaccharide synthesis reactions occur. Third, cisternae at the carrier formation stage produce clathrin-coated vesicles and exchange material with endosomes. At this stage, biosynthetic cargo proteins are packaged into various transport carriers, and the cisternae ultimately disassemble. Discrete transitions occur as a cisterna matures from one stage to the next. Within each stage, the structure and composition of a cisterna can evolve, but the trafficking pathways remain unchanged. This model offers a unified framework for understanding the properties of the Golgi in diverse organisms. PMID:23881164

  16. Bipolar disorder: staging and neuroprogression

    Rodrigues, Aline André; Rosa, Adriana R.; Kunz, Maurício; Ascoli, Bruna; Kapczinski, Flávio

    2014-01-01

    In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the fact that different interventions may suit different stages of the disorder, and that better outcomes...

  17. [Demographic transition at the epoch of industrialization].

    Billig, W

    1984-01-01

    The relationship between the early stages of industrialization and population factors in the United Kingdom, France, and the United States is analyzed from a Marxist perspective. The author attempts to associate successive phases of industrialization with phases of the demographic transition. He concludes that no comprehensive general theory concerning this relationship has been established. (summary in ENG, RUS) PMID:12266382

  18. Corporate governance cycles during transition

    Mygind, Niels; Demina, Natalia; Gregoric, Aleksandra;

    2004-01-01

    -ing or exit stage. During transition the cycle reflects: privatization often with a high proportion of employee ownership like in Russia and in Slovenia; strong pressures for restructuring and owner-ship changes; limited possibility for external finance because of embryonic development of the fi......-nancial system. To provide simple hypothesis tests, we use Russian enterprise data for 1995-2003 and Slovenian data covering 1998-2003. In spite of differences in institutional development, con-cerning privatization and development of corporate governance institutions, we find that govern-ance cycles are broadly...... ownership on managers, external domestic and foreign owners. JEL-codes: G3, J5, P2, P3 - Keywords: corporate governance, life-cycle, privatization, ownership change, transition economies, Russia and Slovenia....

  19. Staged theta pinch experiments

    Two implosion heating circuits are being experimentally tested. The principal experiment in the program is the 4.5-m-long Staged Theta Pinch (STP). It uses two relatively low energy (50kJ and 100 kJ), high voltage (125 kV) capacitor banks to produce the theta pinch plasma inside the 20 cm i.d. quartz discharge tube. A lower voltage (50 kV), higher energy (750 kJ) capacitor bank is used to contain the plasma and provide a variable amount of adiabatic compression. Because the experiment produces a higher ratio of implosion heating to compressional heating than conventional theta pinches, it should be capable of producing high temperature plasmas with a much larger ratio of plasma radius to discharge tube radius than has been possible in the past. The Resonant Heating Experiment (RHX) in its initial configuration is the same as a 0.9-m-long section of the high voltage part of the STP experiment and all the plasma results here were obtained with the experiment in that configuration. Part of the implosion bank will be removed and a low inductance crowbar added to convert it to the resonant heating configuration. (U.K.)

  20. Science on stage

    2005-01-01

    During the opening ceremony, the audience was dazzled by a juggling show involving dramatic light effects. They also took away with them a teacher's sheet explaining some of the scientific concepts involved in juggling. Science teachers can sometimes be quite humorous when it comes to explaining serious matters, as those who took part in the 'Science on Stage' festival held at CERN from 21 to 25 November were able to see for themselves. The 500 or so participants from 27 different countries, mostly science teachers but also some university lecturers, science outreach specialists and students, had the opportunity to share their experience of the teaching of science. They also attended presentations and shows, took part in workshops and visited a fair with stands offering ideas on how to make school science lessons more appealing. The festival, organised by the EIROforum (a partnership between CERN, EFDA, ESA, ESO, EMBL, ESRF and ILL), marked the end of two years of projects for the promotion of science in vir...

  1. Stage-to-stage progression of chronic kidney disease in renal transplantation with chronic allograft dysfunction

    Khalkhali H

    2009-11-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Although the short-term results of kidney transplantation have improved greatly during the past decades, the long-term results have not improved according. Graft loss due to chronic allograft dysfunction (CAD is a major concern in renal transplant recipients (RTRs. There is little data about disease progression in this patient population. In this paper, we investigated history of kidney function as the pattern, waiting time and rate of pass from intermediate stages in RTR with CAD."n"nMethods: In a single-center retrospective study, 214 RTRs with CAD investigated at the Urmia University Hospital urmia, Iran from 1997 to 2005. Kidney function at each visit assessed with GFR. We apply NKF and K/DOQI classification of chronic kidney disease (CKD staging system to determine pattern of disease progression per stage in this group of patients. "n"nResults: The pure death-censored graft loss was 26% with mean waiting time 81.7 months. 100% of RTRs passed from stage I to II in mean waiting time 26.3 months. The probability of prognostic factors transition from stage II to III was 88.9% with mean waiting time 25.5 months, transition from III to IV was 55.7% with mean waiting time of 24.9 months and transition for

  2. Key Relationships for International Student University-to-Work Transitions

    Popadiuk, Natalee Elizabeth; Arthur, Nancy Marie

    2014-01-01

    International student research predominantly focuses on the initial and middle stages of their sojourn. Our research, however, specifically addresses how relationships support international students to successfully navigate the late-stage transition from university to work. In this qualitative study, we interviewed 18 international students from…

  3. The effect of compressed demographic transition and demographic gift on economic growth

    Shin, Inyong

    2013-01-01

    In this paper, we examine the demographic transition and its effect on economic growth using a cross-country data. We use a threshold regression model to verify the transition and to confirm whether the demographic transitions are compressed or not in developing countries. We found out that in general, the demographic transitions, including the decreasing birth and death rate, in developing countries start in an earlier development stage compared to the demographic transitions in developed co...

  4. Gifts from Exoplanetary Transits

    Narita, Norio

    2009-01-01

    The discovery of transiting extrasolar planets has enabled us a number of interesting stduies. Transit photometry reveals the radius and the orbital inclination of transiting planets, and thereby we can learn the true mass and the density of respective planets by the combined information of radial velocity measurements. In addition, follow-up observations of transiting planets such as secondary eclipse, transit timing variations, transmission spectroscopy, and the Rossiter-McLaughlin effect p...

  5. Staged membrane oxidation reactor system

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh

    2012-09-11

    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  6. Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

    Gaur, Shailly; Mandelbaum, Max; Herold, Mona; Majumdar, Himani Datta; Neilson, Karen M; Maynard, Thomas M; Mood, Kathy; Daar, Ira O; Moody, Sally A

    2016-06-01

    The decision by embryonic ectoderm to give rise to epidermal versus neural derivatives is the result of signaling events during blastula and gastrula stages. However, there also is evidence in Xenopus that cleavage stage blastomeres contain maternally derived molecules that bias them toward a neural fate. We used a blastomere explant culture assay to test whether maternally deposited transcription factors bias 16-cell blastomere precursors of epidermal or neural ectoderm to express early zygotic neural genes in the absence of gastrulation interactions or exogenously supplied signaling factors. We found that Foxd4l1, Zic2, Gmnn, and Sox11 each induced explants made from ventral, epidermis-producing blastomeres to express early neural genes, and that at least some of the Foxd4l1 and Zic2 activities are required at cleavage stages. Similarly, providing extra Foxd4l1 or Zic2 to explants made from dorsal, neural plate-producing blastomeres significantly increased the expression of early neural genes, whereas knocking down either significantly reduced them. These results show that maternally delivered transcription factors bias cleavage stage blastomeres to a neural fate. We demonstrate that mouse and human homologs of Foxd4l1 have similar functional domains compared to the frog protein, as well as conserved transcriptional activities when expressed in Xenopus embryos and blastomere explants. genesis 54:334-349, 2016. © 2016 Wiley Periodicals, Inc. PMID:27092474

  7. Staged Repository Development Programmes

    Isaacs, T

    2003-10-01

    Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to

  8. Staged Repository Development Programmes

    Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to maximize the

  9. Research for the energy turnaround. Phase transitions actively shape. Contributions

    The Annual Conference 2014 of the Renewable Energy Research Association was held in Berlin on 6 and 7 November 2014. This book documents the contributions of the conference on research for the energy turnaround, phase transitions actively shape. After an introduction and two contributions to the political framework, the contributions to the economic phases of the energy transition, the phase of the current turn, the phases of social energy revolution, the stages of heat turnaround (Waermewende), and the stages of the mobility turn deal with the stages of development of the energy system. Finally, the Research Association Renewable Energy is briefly presented.

  10. Statistics of Neutron Stars at the Stage of Supersonic Propeller

    Beskin, V S

    2005-01-01

    We analyze the statistical distribution of neutron stars at the stage of a supersonic propeller. An important point of our analysis is allowance for the evolution of the angle of inclination of the magnetic axis to the spin axis of the neutron star for the boundary of the transition to the supersonic propeller stage for two models: the model with hindered particle escape from the stellar surface and the model with free particle escape. As a result, we have shown that a consistent allowance for the evolution of the inclination angle in the region of extinct radio pulsars for the two models leads to an increase in the total number of neutron stars at the supersonic propeller stage. This increase stems from he fact that when allowing for the evolution of the inclination angle $\\chi$ for neutron stars in the region of extinct radio pulsars and, hence, for the boundary of the transition to the propeller stage, this transition is possible at shorter spin periods (P~5-10 s) than assumed in the standard model.

  11. On primordial equation of state transitions

    Aravind, Aditya; Paban, Sonia

    2016-01-01

    We revisit the physics of transitions from a general equation of state parameter to the final stage of slow-roll inflation. We show that it is unlikely for the modes comprising the cosmic microwave background to contain imprints from a pre-inflationary equation of state transition and still be consistent with observations. We accomplish this by considering observational consistency bounds on the amplitude of excitations resulting from such a transition. As a result, the physics which initially led to inflation likely cannot be probed with observations of the cosmic microwave background. Furthermore, we show that it is unlikely that equation of state transitions may explain the observed low multipole power suppression anomaly.

  12. Second stage gasifier in staged gasification and integrated process

    Liu, Guohai; Vimalchand, Pannalal; Peng, Wan Wang

    2015-10-06

    A second stage gasification unit in a staged gasification integrated process flow scheme and operating methods are disclosed to gasify a wide range of low reactivity fuels. The inclusion of second stage gasification unit operating at high temperatures closer to ash fusion temperatures in the bed provides sufficient flexibility in unit configurations, operating conditions and methods to achieve an overall carbon conversion of over 95% for low reactivity materials such as bituminous and anthracite coals, petroleum residues and coke. The second stage gasification unit includes a stationary fluidized bed gasifier operating with a sufficiently turbulent bed of predefined inert bed material with lean char carbon content. The second stage gasifier fluidized bed is operated at relatively high temperatures up to 1400.degree. C. Steam and oxidant mixture can be injected to further increase the freeboard region operating temperature in the range of approximately from 50 to 100.degree. C. above the bed temperature.

  13. Single Cell Proteomics Using Frog (Xenopus laevis) Blastomeres Isolated from Early Stage Embryos, Which Form a Geometric Progression in Protein Content.

    Sun, Liangliang; Dubiak, Kyle M; Peuchen, Elizabeth H; Zhang, Zhenbin; Zhu, Guijie; Huber, Paul W; Dovichi, Norman J

    2016-07-01

    Single cell analysis is required to understand cellular heterogeneity in biological systems. We propose that single cells (blastomeres) isolated from early stage invertebrate, amphibian, or fish embryos are ideal model systems for the development of technologies for single cell analysis. For these embryos, although cell cleavage is not exactly symmetric, the content per blastomere decreases roughly by half with each cell division, creating a geometric progression in cellular content. This progression forms a ladder of single-cell targets for the development of successively higher sensitivity instruments. In this manuscript, we performed bottom-up proteomics on single blastomeres isolated by microdissection from 2-, 4-, 8-, 16-, 32-, and 50-cell Xenopus laevis (African clawed frog) embryos. Over 1 400 protein groups were identified in single-run reversed-phase liquid chromatography-electrospray ionization-tandem mass spectrometry from single balstomeres isolated from a 16-cell embryo. When the mass of yolk-free proteins in single blastomeres decreased from ∼0.8 μg (16-cell embryo) to ∼0.2 μg (50-cell embryo), the number of protein group identifications declined from 1 466 to 644. Around 800 protein groups were quantified across four blastomeres isolated from a 16-cell embryo. By comparing the protein expression among different blastomeres, we observed that the blastomere-to-blastomere heterogeneity in 8-, 16-, 32-, and 50-cell embryos increases with development stage, presumably due to cellular differentiation. These results suggest that comprehensive quantitative proteomics on single blastomeres isolated from these early stage embryos can provide valuable insights into cellular differentiation and organ development. PMID:27314579

  14. Transformation of cluster structure at initial stage

    The initial stages of cluster nucleation for Pd or Ir adatoms on a W (1 1 0) surface and in the vicinity of surface steps are directly imaged by a field ion microscope (FIM). Three types of structures are observed. One is a one-dimensional linear chain, which is parallel to the nearest neighbor-stacking directions of the substrate. Another is a two-dimensional compact island, which is a pseudomorphic structure like the substrate. The other is a three-dimensional cluster, which shows a structural transition from bcc (1 1 0) to fcc (1 1 1). Factors affecting the structural transformation include coverage of atoms or atom chains, temperature of heat treatments and boundary of the substrate terrace.

  15. On modern demographic transition in China.

    1991-12-01

    The theory of demographic transition traditionally indicates 3 historical stages. The limitations of the theory are: 1)studies are confined to phenomenal descriptions which means that China is exempt, 2) it focuses too much on productive forces and ignores the factor of the relation between production and other non-economic factors. There is more to transition theories than birth rate, death rate of natural increase. In 1971 China began the process of modern demographic transition with a death rate of 0.7% and a drop in the birth rate. In 1976 China began the 2nd stage where birth rates doubled which made China a unique case because it fell outside the conventional model. The primary factor for this was the change in the fertility rate. The effects of population policy on fertility will be less if economic development and cultural development do not keep pace. The fact that rural people were reluctant to accept the population policy was a strong factor. The 2nd rise is attributed to the "flexible minor policies". This 2nd rise will be a significant factor in future population development. The key to modern demographic transition in China is to lower the birth rate by: 1) developing economic policies that will increase the quality of social and economic backgrounds, 2) the interference of the policy in demographic transition should follow the medium principle, 3) communication and education should be increased to help people set up the value of less births, better births. PMID:12284673

  16. Data processing in a small transit company using an automatic passenger counter

    Avadhani, Umesh D.

    1986-01-01

    This thesis describes the work done in the second stage of the implementation of the Automatic Passenger Counter (APC) system at the Roanoke Valley - Metro Transit Company. This second stage deals with the preparation of a few reports and plots that would help the transit managers in efficiently managing the transit system. The reports and plots give an evaluation of the system and service operations by which the decision makers can support their decisions. For an efficie...

  17. Multi-stage complex contagions

    Melnik, Sergey; Ward, Jonathan A.; Gleeson, James P.; Porter, Mason A.

    2013-03-01

    The spread of ideas across a social network can be studied using complex contagion models, in which agents are activated by contact with multiple activated neighbors. The investigation of complex contagions can provide crucial insights into social influence and behavior-adoption cascades on networks. In this paper, we introduce a model of a multi-stage complex contagion on networks. Agents at different stages—which could, for example, represent differing levels of support for a social movement or differing levels of commitment to a certain product or idea—exert different amounts of influence on their neighbors. We demonstrate that the presence of even one additional stage introduces novel dynamical behavior, including interplay between multiple cascades, which cannot occur in single-stage contagion models. We find that cascades—and hence collective action—can be driven not only by high-stage influencers but also by low-stage influencers.

  18. ANALYSIS OF EXTRATROPICAL TRANSITION OF TROPICAL CYCLONE OVER MAINLAND CHINA

    朱佩君; 郑永光; 陶祖钰

    2003-01-01

    Typhoon Winnie (1997) experienced three stages after landfall on China: weakening, transition, and re-intensification. The transition is similar to the "complex transition" model proposed by Matano and Sekioka. During the re-intensification stage, the transformed cyclone developed into a pattern of Shapiro-Keyser Cyclone model. From the diagnosis we can find that the cause of Winnie's transition is the intrusion of cold air from the mid- and upper- troposphere and the warm temperature advection in the lower. Winnie redeveloped after transition,which is the result of three vital factors: the warm temperature advection in the lower troposphere, the divergence on the right side of the upper jet entry and the cyclonic vorticity advection in the upper.

  19. The Managerial Transition.

    Kneeland, Steven J.

    1980-01-01

    Having identified the problem of managerial transition in a previous article (CE 510 277), the author outlines a strategy for change which includes performance appraisal, definition of the management structure, and counselling for the individual in transition. (SK)

  20. Successive Transitions in Ecodesign

    Boks, Casper; McAloone, Tim C.

    2008-01-01

    acknowledged scientific research regarding technology transfer and commercialisation. This paper proposes that this maturing process took place through a number of transitions; this is illustrated by discussing characteristic aspects of each transition, together providing a historic account of how academic...

  1. Conceptualizing Transitions to Adulthood

    Wyn, Johanna

    2014-01-01

    This chapter provides an overview of theories of the transition to young adulthood. It sets out the argument for conceptual renewal and discusses some implications of new patterns of transition for adult education.

  2. Deconstructing transitional justice.

    Turner, C

    2013-01-01

    Transitional justice as a field of inquiry is a relatively new one. Referring to the range of mechanisms used to assist the transition of a state or society from one form of (usually repressive) rule to a more democratic order, transitional justice has become the dominant language in which the move from war to peace is discussed in the early twenty-first century. Applying a deconstructive analysis to the question of transitional justice, the paper seeks to interrogate the core assumptions tha...

  3. Cities in Transition

    Shepotylo Oleksandr

    2012-01-01

    This paper looks at the urban development of transition countries in 1991–2010, primarily focusing on the last decade. Cities in transition face a unique set of challenges that came forth due to interplay of the legacy of socialist urban policies and the transition to the market economy. The socialist urban policies restrained growth of the largest cities and distorted the spatial equilibrium towards more uniform distribution of urban population. The transition to the market economy reduces d...

  4. Cosmological phase transitions

    Kolb, E.W. [Fermi National Accelerator Lab., Batavia, IL (United States)]|[Chicago Univ., IL (United States)

    1993-10-01

    If modern ideas about the role of spontaneous symmetry breaking in fundamental physics are correct, then the Universe should have undergone a series of phase transitions early in its history. The study of cosmological phase transitions has become an important aspect of early-Universe cosmology. In this lecture I review some very recent work on three aspects of phase transitions: the electroweak transition, texture, and axions.

  5. Cosmological phase transitions

    If modern ideas about the role of spontaneous symmetry breaking in fundamental physics are correct, then the Universe should have undergone a series of phase transitions early in its history. The study of cosmological phase transitions has become an important aspect of early-Universe cosmology. In this lecture I review some very recent work on three aspects of phase transitions: the electroweak transition, texture, and axions

  6. Transitive nonpropelinear perfect codes

    Mogilnykh, I. Yu.; Solov'eva, F. I.

    2014-01-01

    A code is called transitive if its automorphism group (the isometry group) of the code acts transitively on its codewords. If there is a subgroup of the automorphism group acting regularly on the code, the code is called propelinear. Using Magma software package we establish that among 201 equivalence classes of transitive perfect codes of length 15 from \\cite{ost} there is a unique nonpropelinear code. We solve the existence problem for transitive nonpropelinear perfect codes for any admissi...

  7. Dynamical transition of heat transport in a physical gel near the sol-gel transition

    Kobayashi, Kazuya U.; Oikawa, Noriko; Kurita, Rei

    2015-12-01

    We experimentally study heat transport in a gelatin solution near a reversible sol-gel transition point where viscosity strongly depends on temperature. We visualize the temperature field and velocity field using thermochromic liquid crystals and polystyrene latex particles, respectively. During the initial stages of heating, we find that heat transport undergoes a dynamical transition from conductive to convective. Subsequently, during later stages, we observe that the transport dynamics are much more complex than conventional thermal convections. At the sample’s surface we observe the formation of stagnant domains, which lack fluid flow. Their formation is not due to the effects of local cooling. We determine that it is the dynamics of these stagnant domains that induce convective-conductive-convective transitions.

  8. Transitivity of Preferences

    Regenwetter, Michel; Dana, Jason; Davis-Stober, Clintin P.

    2011-01-01

    Transitivity of preferences is a fundamental principle shared by most major contemporary rational, prescriptive, and descriptive models of decision making. To have transitive preferences, a person, group, or society that prefers choice option "x" to "y" and "y" to "z" must prefer "x" to "z". Any claim of empirical violations of transitivity by…

  9. Stages of Childhood Soft Tissue Sarcoma

    ... Stage I Stage I is divided into stages IA and IB: In stage IA , the tumor is low grade (likely to grow ... tumor does not place any vital organs in danger. Hormone therapy Hormone therapy is a cancer treatment ...

  10. The Many Worlds of Transition Research.

    Narasimha, R.

    2007-01-01

    The transition from laminar to turbulent flow in a boundary layer is a complex phenomenon that may take different routes, each involving distinct stages governed by different, often not-yet unraveled dynamical principles. There are, surprisingly, questions concerning virtually every stage in the process, beginning with receptivity to external disturbances, the linear stability of spatially developing flows, different possible nonlinear end games, the formation and propagation of turbulent spots and the emergence of fully developed turbulent flow. There seems no doubt that the flow has to be seen as a forced, nonlinear spatio-temporal system, but the system is so complex that to extract simple insights is still very difficult.

  11. Staging of unipolar affective illness

    Ewa Ferensztajn

    2014-12-01

    Full Text Available In this article, a concept of staging of unipolar affective illness (recurrent depression is presented. In respective subchapters, three most important aspects of this issue have been discussed: 1 staging of unipolar affective illness; 2 staging of treatment-resistant depression; and 3 conversion of unipolar into bipolar affective illness. The evidence for so called neuroprogression of the illness, accumulated in recent years, has allowed for a classification of staging based on a concept of allostasis and allostatic load. In the course of illness, changes in neuroendocrine system (mainly hypothalamic pituitary-adrenal (HPA axis, immunological system, mechanisms of oxidative stress, neurotransmitters, neurotrophic factors as well as structural and functional changes of the brain occur. In their paper of 2007, Fava and Tossani elaborated a concept of staging of unipolar affective illness presenting a continuum model of five consecutive stages with specific clinical features. In the present paper, a concept of treatment-resistant depression and staging of treatment resistance is presented in the context of several models. An important determinant of treatment-resistant depression is so called subthreshold bipolarity which is connected with worse efficacy of antidepressant drugs. In the course of illness, there is a possibility of changing diagnosis from recurrent depression into bipolar affective illness. The studies on this issue show that frequency of such diagnostic conversion is 1,5% of depressed patients per year.

  12. Nuclear-magnetic-resonance characterization of the defect migrating during stage III in electron-irradiated copper

    Nuclear quadrupolar couplings around monovacancies created by electron irradiation in copper have been measured by the nuclear-magnetic-resonance field-cycling technique. The corresponding quadrupolar transitions disappear completely after the annealing stage III of the residual resistivity, while 17% of the initial resistivity increase remains. Consequently, this experiment shows unambiguously that all the monovacancies are annihilated or agglomerate during stage III and rules out the model in which split interstitials migrate during stage III and monovacancies during stage IV

  13. Vaccine Therapy in Treating Patients With Stage IIIC-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer Following Surgery and Chemotherapy

    2016-01-07

    Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Tumor; Fallopian Tube Mucinous Neoplasm; Fallopian Tube Serous Neoplasm; Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Mixed Epithelial Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

  14. Transition Theory – Sustainable Transition of Socio-Technical Systems

    Søndergård, Bent; Holm, Jesper; Stauning, Inger

    Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction......Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction...

  15. Cognitive Development and Group Stages.

    Saidla, Debie D.

    1990-01-01

    Attempts to integrate Perry's (1970) scheme of the cognitive development of college students with a model of group development adapted by Waldo (1985) based on Tuckman's (1965) formulation of developmental group stages. (Author)

  16. Radiological staging of bronchogenic cancer

    Staging of the bronchogenic carcinoma is based on the TNM code; radiological imaging and radionuclide scanning account for most of the preoperative assessment of the tumor stage. A series of 206 patients was evaluated by chest radiography, mediastinal and hilar tomography, CT of the thorax, upper abdomen and brain. The pathological correlations performed after surgery showed that CT provided a correct T in 175 patients out of 206 (= 84.9%), while conventional radiology gave only 120 correct diagnoses (58.2%). In assessment of N1, sensitivity was 53%, specificity 85.3%, diagnostic accuracy 77.7%. Pertinent figures for N2 were 81.8 - 88.3 - 86.9%. The reliability of CT in staging for M is difficult to assess, because tha majority of patients who showed distant metastases were not operated upon. The main problems concerning evaluation criteria for staging are discussed. (Author)

  17. How Is Endometrial Cancer Staged?

    ... organs away from the uterus, such as the lungs or bones. The cancer can be any size and it may or may not have spread to ... and Staging Treating Endometrial Cancer Talking With Your Doctor After ...

  18. Neuroblastoma: diagnostic imaging and staging

    Results of computed tomography (CT), scintigraphy, excretory urography, and other imaging tests used to diagnose and stage 38 cases of neuroblastoma prior to treatment were reviewed. Findings of these examinations were correlated with clinical data, laboratory data, results of biopsy, and surgical findings. CT was the most sensitive single test (100%) for the detection and delineation of the primary tumor. Calcifications that suggested the histologic diagnosis of neuroblastoma were present in 79% of the cases. Rim calcifications, the most specific pattern for neuroblastoma, were identified in 29% of all cases. CT alone accurately staged 82% of cases; when complemented by bone marrow biopsy, staging accuracy was 97%. CT alone was more accurate than any combination of imaging tests that excluded CT. An algorithm using CT is presented for the diagnosis and staging of neuroblastoma at reduced cost and with increased efficiency

  19. Life stage, not climate change, explains observed tree range shifts.

    Máliš, František; Kopecký, Martin; Petřík, Petr; Vladovič, Jozef; Merganič, Ján; Vida, Tomáš

    2016-05-01

    Ongoing climate change is expected to shift tree species distribution and therefore affect forest biodiversity and ecosystem services. To assess and project tree distributional shifts, researchers may compare the distribution of juvenile and adult trees under the assumption that differences between tree life stages reflect distributional shifts triggered by climate change. However, the distribution of tree life stages could differ within the lifespan of trees, therefore, we hypothesize that currently observed distributional differences could represent shifts over ontogeny as opposed to climatically driven changes. Here, we test this hypothesis with data from 1435 plots resurveyed after more than three decades across the Western Carpathians. We compared seedling, sapling and adult distribution of 12 tree species along elevation, temperature and precipitation gradients. We analyzed (i) temporal shifts between the surveys and (ii) distributional differences between tree life stages within both surveys. Despite climate warming, tree species distribution of any life stage did not shift directionally upward along elevation between the surveys. Temporal elevational shifts were species specific and an order of magnitude lower than differences among tree life stages within the surveys. Our results show that the observed range shifts among tree life stages are more consistent with ontogenetic differences in the species' environmental requirements than with responses to recent climate change. The distribution of seedlings substantially differed from saplings and adults, while the distribution of saplings did not differ from adults, indicating a critical transition between seedling and sapling tree life stages. Future research has to take ontogenetic differences among life stages into account as we found that distributional differences recently observed worldwide may not reflect climate change but rather the different environmental requirements of tree life stages. PMID

  20. Significant change of sensitivity index d' in sensory processing of human brain during wake-sleep transition

    Chuang Gao; Fengjuan Zhang; Wei Wei; Yang Zhang; Shanyu Ke

    2011-01-01

    The sensor area in the brain remains active during the wake-sleep transition. However, the behavioral mechanisms of sensor sensitivity involved in the transition from a state of wakefulness to a sleep state remain poorly understood. To detect sensitivity index (d') changes during the wake-sleep transition, the present study recorded response times of wakefulness versus wake-sleep transition in 14 healthy undergraduate volunteers. During wake-sleep transition testing, morphological changes in the time courses of behavior response revealed 2 typical phases (stages A and B). In stage A, subject behavior responses exhibited temporal fluctuations, and all subjects displayed a high accuracy rate. In stage B, subjects did not exhibit behavioral responses. The sensitivity index d' during the wake-sleep transition (stage A) was significantly weaker than during wakefulness. Results demonstrated that at the behavioral level, sensation capacity for transfer information from the external world into the internal system significantly decreased during the transition to sleep.

  1. The Staging of the Turk

    Holm, Bent

    2013-01-01

    An analytical and contextualized presentation of the figure of the Turk on the Danish stage in the 18. century with a specific focus on the interaction between the actual commercial and military circumstances on the one hand and the performative representations on the other hand. How far did the ...... staged image reflect the actual circumstances and how far was it an internal self-reflection?...

  2. Mediastinal Staging for Lung Cancer

    Jacob Gelberg; Sean Grondin; Alain Tremblay

    2014-01-01

    Staging of the mediastinal and hilar lymph nodes plays a crucial role in identifying the best treatment option for patients with confirmed or suspected lung cancer and, in many cases, can simultaneously confirm a diagnosis of cancer. Noninvasive modalities, such as computed tomography (CT), positron emission tomography (PET) and PET-CT, are an important first step in this assessment. Ultimately, invasive staging is frequently required to confirm or rule out the presence of metastatic disease ...

  3. Invasive staging of the mediastinum

    Wever, W De; Coolen, J; Verschakelen, J.

    2013-01-01

    Staging of patients with lung cancer provides accurate information on the extent of disease and guides the choice of treatment. Non-invasive imaging techniques are safe, however these imaging techniques have limited accuracy in detection of mediastinal lymph node metastases. The American College of Chest Physicians guidelines for lung cancer staging recommend that patients with abnormal lymph nodes on CT or PET, or centrally located tumors without mediastinal LNs, should undergo invasive stag...

  4. Sibling Relationships during the Transition to Adulthood

    Conger, Katherine Jewsbury; Little, Wendy M.

    2010-01-01

    Recent research has shed new light on individual development during the early adulthood years, yet few investigators have examined sibling relationships during this stage of life. These relationships undergo transformations as individuals enter adult roles and orient their lives towards friends and romantic partners and establish independence from parents and siblings. This review examines major life events and role transitions such as leaving home, completing school, obtaining employment, ge...

  5. Staging of pediatric abdominal malignancies

    The scope of this review is the role of CT in the staging of childhood solid abdominal malignancies. Owing to the limitations of space, only the commonest lesions will be discussed in detail: Wilms' tumor, neuroblastoma, and liver tumors. The TNM staging system has been utilized throughout this monograph. It will not be used in this chapter, however, since in this country different staging systems individualized to each pediatric tumor have been developed. These staging systems take into account the different biology of each tumor and have clear correlations with prognosis and therapeutic programs. The discussion centers almost exclusively on the role of CT in the staging and management of neoplastic processes in children. The information required for staging can sometimes be obtained by other imaging modalities (i.e., ultrasound, excretory urography, etc.) The choice of modality will be strongly influenced by techniques and expertise available as well as by the bias of the institution. An additional factor to be taken into consideration will be the economic factor. Prospective reimbursement will strongly encourage the use of tests that are cost-effective and clinically efficacious

  6. Transitions in endocrinology: treatment of Turner's syndrome during transition.

    Gawlik, Aneta; Malecka-Tendera, Ewa

    2014-02-01

    Transition in health care for young patients with Turner's syndrome (TS) should be perceived as a staged but uninterrupted process starting in adolescence and moving into adulthood. As a condition associated with high risk of short stature, cardiovascular diseases, ovarian failure, hearing loss and hypothyroidism, TS requires the attention of a multidisciplinary team. In this review paper, we systematically searched the relevant literature from the last decade to discuss the array of problems faced by TS patients and to outline their optimal management during the time of transfer to adult service. The literature search identified 233 potentially relevant articles of which 114 were analysed. The analysis confirmed that all medical problems present during childhood should also be followed in adult life. Additionally, screening for hypertension, diabetes mellitus, dyslipidaemia, and osteoporosis is needed. After discharge from the paediatric clinic, there is still a long way to go. PMID:24225028

  7. Atomic Transition Probabilities Scandium through Manganese

    Atomic transition probabilities for about 8,800 spectral lines of five iron-group elements, Sc(Z = 21) to Mn(Z = 25), are critically compiled, based on all available literature sources. The data are presented in separate tables for each element and stage of ionization and are further subdivided into allowed (i.e., electric dipole-E1) and forbidden (magnetic dipole-M1, electric quadrupole-E2, and magnetic quadrupole-M2) transitions. Within each data table the spectral lines are grouped into multiplets, which are in turn arranged according to parent configurations, transition arrays, and ascending quantum numbers. For each line the transition probability for spontaneous emission and the line strength are given, along with the spectroscopic designation, the wavelength, the statistical weights, and the energy levels of the upper and lower states. For allowed lines the absorption oscillator strength is listed, while for forbidden transitions the type of transition is identified (M1, E2, etc.). In addition, the estimated accuracy and the source are indicated. In short introductions, which precede the tables for each ion, the main justifications for the choice of the adopted data and for the accuracy rating are discussed. A general introduction contains a discussion of our method of evaluation and the principal criteria for our judgements

  8. The interpersonal relationship: Transitions of university professors

    Fabiula Meneguete Vides da Silva

    2014-07-01

    Full Text Available In this paper we search to understand the meaning of interpersonal relationships established in the processes of transition from individual contributor (teacher to lead (dean and leading contributor to individual universities. The phenomenological-hermeneutic approach of van Manen (1990 was used to resume the main themes of this experience. Six former university administrators lent their experiences at universities belonging to the Santa Catarina Association of Educational Foundations (ACAFE, through interviews in three stages suggested by Seidman (1998, conducted between May 2009 and March 2010. Drawing on interviews transcribed, it was possible to rescue three major central themes, which represent the interpersonal relationships that the teachers interviewed lived in the transition to deans: professional relationships, relationships with students and family relations: feeling support and billing. By taking on the management of the university, former managers perceived support from family, but also charging for longer commitment. In the transition from deans for teachers were rescued two themes: professional relations and family living the transition. Interpersonal relationships experienced by ex-managers, after leaving the offices, were important in the transition to the classroom. Relationships with co-workers were a source of joys and disappointments for teachers. While the support of family and friends was of paramount importance, providing them with nurturing and safety. The data revealed through the experiences of teachers reveal issues relevant to the understanding of interpersonal relationships experienced during the transitions studied, bringing thus contributions to thinking in human resource policies.

  9. Quantum phase transitions

    In recent years, quantum phase transitions have attracted the interest of both theorists and experimentalists in condensed matter physics. These transitions, which are accessed at zero temperature by variation of a non-thermal control parameter, can influence the behaviour of electronic systems over a wide range of the phase diagram. Quantum phase transitions occur as a result of competing ground state phases. The cuprate superconductors which can be tuned from a Mott insulating to a d-wave superconducting phase by carrier doping are a paradigmatic example. This review introduces important concepts of phase transitions and discusses the interplay of quantum and classical fluctuations near criticality. The main part of the article is devoted to bulk quantum phase transitions in condensed matter systems. Several classes of transitions will be briefly reviewed, pointing out, e.g., conceptual differences between ordering transitions in metallic and insulating systems. An interesting separate class of transitions is boundary phase transitions where only degrees of freedom of a subsystem become critical; this will be illustrated in a few examples. The article is aimed at bridging the gap between high-level theoretical presentations and research papers specialized in certain classes of materials. It will give an overview on a variety of different quantum transitions, critically discuss open theoretical questions, and frequently make contact with recent experiments in condensed matter physics

  10. Monetary Policy Rules in Some Transition Economies

    Mohamed El-Hodiri

    2014-12-01

    Full Text Available In this paper we examine the question of whither monetary rules or ad hoc monetary policies were followed during the early stages of transition and in response to the global financial crisis. We study Eastern European countries and thee CIS countries. We find that during the early of transition, both developed economies and economies in transition used the monetary base, as well as the interest rate, as the main tools for monetary policy. However, in response to the global crises, priority was given to the main objective such as containing inflation and supporting economic growth. Monetary authorities had the additional possible choice of alternative objectives, such as stabilization of nominal exchange rate and real effective exchange rate, or increase in reserves. It was found that countries mostly retained priorities of monetary policy and some of them gave a greater importance to the alternative objectives.

  11. Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji.

    Fitzgerald-Bocarsly, P; Feldman, M; Curl, S; Schnell, J; Denny, T

    1989-08-15

    Previous studies from our laboratory indicated that human NK activity against HSV-infected fibroblasts (HSV-Fs) but not K562 targets was sensitive to treatment with anti-HLA-DR plus C. In the current study, we have selected Leu-11a+ (CD-16) cells by fluorescence activated cell sorting and found that although Leu-11a enriched populations lysed K562 targets in 14-h 51Cr-release assays, they were unable to kill HSV-Fs targets unless a Leu-11a-depleted population was added back to the effectors or unless known activators of NK cells (IFN-alpha or IL-2) were added to the assays. In contrast, Leu-11a-enriched populations were able to mediate ADCC against HSV-Fs in the presence of sera from HSV-seropositive individuals without the requirement for accessory cells. We have begun preliminary characterization of the accessory cells which allow lysis of HSV-Fs by NK cells: they are HLA-DR+ cells which enrich in the light density fractions of Metrizamide density gradients. They need be present in very small numbers for lysis to take place and are not MHC restricted in that heterologous add-backs between anti-HLA-DR plus C and anti-Leu-11b plus C-treated populations are capable of target cell lysis at levels similar to those achieved with the autologous add-backs. Further, the levels of lysis in heterologous add-back experiments reflected the lytic potential of the effector rather than the accessory cell donor. Finally, although the requirement for accessory cells for NK lysis has been demonstrated for fibroblasts infected with HSV-1, CMV, and VZV, lysis of HSV-infected Raji lymphoblastoid cells is relatively accessory-cell independent, indicating that the requirement for accessory cells for lysis by NK cells is not a property of all herpesvirus-infected targets. PMID:2526183

  12. Gravitationally induced quantum transitions

    Landry, A.; Paranjape, M. B.

    2016-06-01

    In this paper, we calculate the probability for resonantly inducing transitions in quantum states due to time-dependent gravitational perturbations. Contrary to common wisdom, the probability of inducing transitions is not infinitesimally small. We consider a system of ultracold neutrons, which are organized according to the energy levels of the Schrödinger equation in the presence of the Earth's gravitational field. Transitions between energy levels are induced by an oscillating driving force of frequency ω . The driving force is created by oscillating a macroscopic mass in the neighborhood of the system of neutrons. The neutron lifetime is approximately 880 sec while the probability of transitions increases as t2. Hence, the optimal strategy is to drive the system for two lifetimes. The transition amplitude then is of the order of 1.06 ×10-5, and hence with a million ultracold neutrons, one should be able to observe transitions.

  13. Predictability of Critical Transitions

    Zhang, Xiaozhu; Hallerberg, Sarah

    2015-01-01

    Critical transitions in multistable systems have been discussed as models for a variety of phenomena ranging from the extinctions of species to socio-economic changes and climate transitions between ice-ages and warm-ages. From bifurcation theory we can expect certain critical transitions to be preceded by a decreased recovery from external perturbations. The consequences of this critical slowing down have been observed as an increase in variance and autocorrelation prior to the transition. However especially in the presence of noise it is not clear, whether these changes in observation variables are statistically relevant such that they could be used as indicators for critical transitions. In this contribution we investigate the predictability of critical transitions in conceptual models. We study the the quadratic integrate-and-fire model and the van der Pol model, under the influence of external noise. We focus especially on the statistical analysis of the success of predictions and the overall predictabil...

  14. Bus rapid transit

    Wright, Lloyd

    2002-01-01

    Effective public transit is central to development. For the vast majority of developing city residents, public transit is the only practical means to access employment, education, and public services, especially when such services are beyond the viable distance of walking or cycling. Unfortunately, the current state of public transit services in developing cities often does little to serve the actual mobility needs of the population. Bus services are too often unreliable, inconvenient and ...

  15. The Talmud On Transitivity

    Shlomo Naeh; Uzi Segal

    2008-01-01

    Transitivity is a fundamental axiom in Economics that appears in consumer theory, decision under uncertainty, and social choice theory. While the appeal of transitivity is obvious, observed choices sometimes contradict it. This paper shows that treatments of violations of transitivity al- ready appear in the rabbinic literature, starting with the Mishnah and the Talmud (1st–5th c CE). This literature offers several solutions that are similar to those used in the modern economic literature, as...

  16. Computing quantum phase transitions

    Vojta, Thomas

    2007-01-01

    This article first gives a concise introduction to quantum phase transitions, emphasizing similarities with and differences to classical thermal transitions. After pointing out the computational challenges posed by quantum phase transitions, a number of successful computational approaches is discussed. The focus is on classical and quantum Monte Carlo methods, with the former being based on the quantum-to classical mapping while the latter directly attack the quantum problem. These methods ar...

  17. PET in lung cancer staging

    The primary clinical application of FDG-PET is in the evaluation of patients with lung cancer and includes diagnosis, staging and restaging of non-small cell lung cancer. PET has a very high accuracy (sensitivity=97%, specificity=78%) for characterizing nodules that are indeterminate by chest radiograph and computed tomography. The major utility of PET in the evaluation of patients with lung cancer is the staging of the entire body. PET is more accurate than the conventional imaging modalities of CT and bone scans in the detection of metastatic disease. PET is accurate in the staging of the mediastinum, adrenal glands, and the skeletal system. PET is not as accurate in the detection of brain metastases because of their small size and the normal cortical accumulation

  18. Staged separation of craniopagus twins.

    Dunaway, David; Jeelani, N U Owase

    2015-10-01

    Craniopagus twins are rare and account for up to 6% of all conjoined twins. No hospital will encounter many such twins and the opportunity to develop expertise is limited. We have dealt with 2 such sets and illustrate our approach by reference to our most recent set. We believe that detailed imaging allows precise delineation of the anatomy and facilitates detailed planning of the surgery. When venous drainage from the 2 brains is connected, we believe that staged separation is preferable as gradual alteration of hemodynamics may be safer than a single-stage procedure. PMID:26382265

  19. Hypertension Management in Transition: From CKD to ESRD.

    Valika, Aziz; Peixoto, Aldo J

    2016-07-01

    Hypertension is present in ∼90% of patients in late-stage CKD. There are scarce data focusing on the transition period between CKD Stages 4 and 5 (end-stage kidney disease) as it relates to hypertension evaluation and management. Here, we propose that a combination of the principles used in the management of patients with CKD Stages 4 and 5 be applied to patients in this transition. These include the use of out-of-office blood pressure (BP) monitoring (eg, home BP), avoidance of excessively tight BP goals, emphasis of sodium restriction, preferential use of blockers of the renin-angiotensin system and diuretics, and consideration of the use of beta blockers. PMID:27324679

  20. Labour market states, mobility and entrepreneurship in transition economies

    Mark Dutz; Celine Kauffmann; Serineh Najarian; Peter Sanfey; Ruslan Yemtsov

    2001-01-01

    This paper examines the different strategies adopted by individuals in transition economies to cope with labour market restructuring. Using micro-data from seven countries at different stages of transition, we focus on “active” coping strategies, in particular mobility and entrepreneurship. Our results show that there is significant mobility across labour market states in most countries, but little inflow into entrepreneurship from unemployment or inactivity. Entrepreneurship is a high-reward...

  1. A life course perspective on health trajectories and transitions

    Burton-Jeangros, Claudine; Cullati, Stéphane; Sacker, Amanda; Blane, David

    2015-01-01

    This book examines health trajectories and health transitions at different stages of the life course, including childhood, adulthood and later life. It provides findings that assess the role of biological and social transitions on health status over time.The essays examine a wide range of health issues, including the consequences of military service on body mass index, childhood obesity and cardiovascular health, socio-economic inequalities in preventive health care use, depression and anxiet...

  2. Transitioning between Clerkship Directors

    Soltys, Stephen M.; Pary, Robert J.; Robinson, Stephen W.; Markwell, Stephen J.

    2011-01-01

    Objective: The authors report on succession-planning for mid-level academic positions. Method: The authors describe the process of succession-planning between clerkship directors and the smooth transition resulting in one case. Results: Gradually transitioning allowed a new faculty person to assume the clerkship-director position with minimal…

  3. Transitions in Spousal Caregiving.

    Burton, Lynda C.; Zdaniuk, Bozena; Schulz, Richard; Jackson, Sharon; Hirsch, Calvin

    2003-01-01

    Describes transitions over 5 years among community-dwelling elderly spouses into and within caregiving roles and associated health outcomes. The trajectory of health outcomes associated with caregiving was generally downward. Those who transitioned to heavy caregiving had more symptoms of depression, and poorer self-reported health and health…

  4. Urban renewal in transition

    Stouten, P.

    1995-01-01

    Urban renewal in transition consists revised and enlarged version of two papers. The first paper 'urban renewal and restructuring: between economie and social renewal' had been presented at the conference 'Labour on the move and transitions in the building process', organlzed by the Bartlett School

  5. Origins of evolutionary transitions

    Ellen Clarke

    2014-04-01

    An `evolutionary transition in individuality’ or `major transition’ is a transformation in the hierarchical level at which natural selection operates on a population. In this article I give an abstract (i.e. level-neutral and substrate-neutral) articulation of the transition process in order to precisely understand how such processes can happen, especially how they can get started.

  6. Transition probabilities for atoms

    Current status of advanced theoretical methods for transition probabilities for atoms and ions is discussed. An experiment on the f values of the resonance transitions of the Kr and Xe isoelectronic sequences is suggested as a test for the theoretical methods

  7. Researching Student Transitions

    Voorhees, Richard A.; Smith, Gregory P.; Luan, Jing

    2006-01-01

    This article sketches a research agenda for the further study of community college student transitions. Specific techniques are depicted as are potential data sources that can be used to pursue that agenda. The role of student tracking systems in transition research is discussed as well as the applicability of national surveys to the study of…

  8. Induced Institutional Transition of Contract Farming in Shandong Province

    Sun, Bao-Chun

    2010-01-01

    This article describes the process of institutional transition of contract farming in Shandong Province. The changes in preparatory stage of contract farming express in: One, the information asymmetry of the two sides of the contract is reducing; Two, the security system of contract farming tends to be perfection; Three, the organizational form of contract farming tends to be simplification. The measures taken in production stage of agricultural product are as follows: The first is investment...

  9. The transition from preoperative to operational thinking of children

    Klašnja, Dijana

    2014-01-01

    The theoretical part of this diploma thesis focuses on Jean Piaget's theory of cognitive development. The thesis discusses the characteristics of Piaget's theory, the employed research method and the developmental factors affecting the cognitive development of children. The largest part of this section focuses on the characteristics of the individual stages of cognitive development. Since the thesis examines the transition from the preoperational to the operational stage of intellectual devel...

  10. Laboratory experiment on boundaries of upper stage plane bed regime

    Zrostlík, Štěpán; Matoušek, Václav

    2016-04-01

    Results are discussed of laboratory experiments on criteria determining the transition between the regime of dunes and the upper stage plane bed (UPB) regime and the transition between the UPB regime and the regime of wavy flow. The experiments were carried for 3 fractions of plastic material and two fractions of glass beads in a broad range of flow conditions (different discharges of water and solids and longitudinal bed slopes) in a tilting flume. The experiments reveal that, contrary to expectations, a constant value of the Shields parameter is not an appropriate criterion for the transition between the dune regime and the UPB regime. Furthermore, the transition appears to be insensitive to the total discharge of solids and water. Instead, the criterion seems to be well represented by a constant value of the average transport concentration of sediment (the ratio of volumetric discharge of solids and volumetric discharge of mixture). The experimental results exhibit a very tight correlation between the transport concentration and the longitudinal bed slope. Hence, a constant value of the bed slope can be considered an appropriate criterion for the transition. The transition between the UPB regime and the wavy regime (significant waves develop but they are not always standing waves) is found at a constant value of Froude number, which is in agreement with literature, although it is found at a higher value than the literature usually suggests (Fr = 1.2 instead of 1.0). Hence, the transition occurs in the super-critical flow but it is not necessarily associated with the critical flow.

  11. When science takes centre stage

    2005-01-01

    The teachers at 'Science on stage' are not emotionally attached to their chalk. Neither are they are weary old men who sport tweed jackets with elbow-patches and enter into conversation with their blackboards. Actually, 'Science on stage' teachers are far from the cliché of the boring physics teacher who can only inspire yawns from his pupils. Some present the basic principles of mechanics using a bicycle, others explain chemistry with examples from everyday life. The most audacious of them go so far as to explain the Doppler effect by means of a play in which Einstein dreams about jumping cows... These are but a few of the activities and plays that will be shown during the EIROforum1 Science on Stage Festival (organised by 7 European scientific organisations including CERN), to be held from 21 to 25 November at CERN, Geneva. This festival is dedicated to the teaching science in order to make it more attractive. After the first edition 'Physics on Stage' which was held in 2000 at CERN, the laboratory agai...

  12. Stage 2--Information Seeking Strategies

    Elsenberg, Michael B.

    2005-01-01

    A brief overview of one Big6 stage by Mike Eisenberg, followed by articles by two exemplary Big6 teachers, Barbara Jansen and Rob Darrow, offering practical uses of the Big6 in elementary and secondary situations is presented. The two-part nature of information seeking strategies that includes brainstorming and choosing is emphasized.

  13. Early stage fuel cell funding

    'Full text:' Early stage venture funding requires an in depth understanding of both current and future markets as well as the key technical hurdles that need to be overcome for new technology to commercialize into successful products for mass markets. As the leading fuel cell and hydrogen investor, Chrysalix continuously reviews global trends and new technologies, evaluates them with industry leaders worldwide and tries to match them up with the best possible management teams when selecting its early stage investments. Chrysalix Energy Limited Partnership is an early-stage venture capital firm focusing on fuel cell and related fueling technology companies and is a private equity joint venture between Ballard Power Systems, BASF Venture Capital, The BOC Group, The Boeing Company, Duke Energy, Mitsubishi Corporation and Shell Hydrogen. Operating independently, Chrysalix offers a unique value proposition to its clients throughout the business planning, start-up and operations phases of development. Chrysalix provides early-stage funding to new companies as well as management assistance, technological knowledge, organized networking with industry players and experience in the management of intellectual property. (author)

  14. Tumor diagnosis, grading, and staging

    Optimal use of radiation therapy for the treatment of animal tumors necessitates accurate clinical evaluation, diagnostic imaging, and pathology. This requires a coordinated effort between the clinical and radiation oncologist, radiologist, and pathologist. The histological appearance of the tumor, tumor grade, and tumor stage are important diagnostic criteria that need to be established. Diagnostic imaging, including radiographic, computerized tomographic, magnetic resonance imaging, and ultrasound studies are helpful in establishing an accurate tumor location and diagnosis. Biopsy and histological examination of tumor tissue are necessary for final diagnosis of tumor type. Determination of tumor type is critical because different tumor types vary in regard to radiosensitivity, local behavior, and propensity for regional and systemic metastasis. The histological grade of many tumors is an important indicator of the potential for local invasion or systemic metastases, and may influence treatment response. Tumor staging as determined by clinical evaluation, imaging studies, and histological evaluation is necessary to establish the extent of the tumor, both locally, regionally, and systemically. The clinical oncologist should have an understanding of the procedures involved in tumor diagnosis, tumor grading, and tumor staging. This provides a better understanding of the neoplastic condition and recognition of the limitations of diagnostic procedures. Tumor type, grade, and stage all impact radiation treatment planning and the need for adjuvant regional or systemic therapy

  15. Staging Urban Experiences in Suburbia

    Jantzen, Christian; Vetner, Mikael

    2009-01-01

    Urban design provides props, requisites and decors for staging the users' performances in space. Design may facilitate or impede specific ways of moving around, interacting with objects and other people, feeling, learning and sense making.The actual design may very well contradict the explicit...

  16. Cosmological phase transitions

    If the universe stated from conditions of high temperature and density, there should have been a series of phase transitions associated with spontaneous symmetry breaking. The cosmological phase transitions could have observable consequences in the present Universe. Some of the consequences including the formation of topological defects and cosmological inflation are reviewed here. One of the most important tools in building particle physics models is the use of spontaneous symmetry breaking (SSB). The proposal that there are underlying symmetries of nature that are not manifest in the vacuum is a crucial link in the unification of forces. Of particular interest for cosmology is the expectation that are the high temperatures of the big bang symmetries broken today will be restored, and that there are phase transitions to the broken state. The possibility that topological defects will be produced in the transition is the subject of this section. The possibility that the Universe will undergo inflation in a phase transition will be the subject of the next section. Before discussing the creation of topological defects in the phase transition, some general aspects of high-temperature restoration of symmetry and the development of the phase transition will be reviewed. 29 references, 1 figure, 1 table

  17. Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer

    John Hoff

    2014-01-01

    Full Text Available Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC and SEER institutions. Results. Cytoreduction to no visible disease (P<0.0001 and complete response to platinum-based chemotherapy (P<0.025 occurred more frequently in Stage IIIA than in Stage IIIC cases. Time to progression was shorter in patients with Stage IIIC ovarian cancer (17±1 months than in those with Stage II1A disease (36±8 months. Five-year overall survival (OS improved from 41% in Stage IIIC patients to 60% in Stage IIIA patients treated at UKMCC and from 37% to 56% in patients treated at SEER institutions for a survival advantage of 19% in both data sets. 53% of Stage IIIA and 14% of Stage IIIC patients had NED at last followup. Conclusions. Decreasing stage at detection from Stage IIIC to stage IIIA epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor cytoreduction and platinum-based chemotherapy.

  18. General principles and stages of optimal AFCS design

    Platonov, A.; Zaitsev, Ie.

    2014-11-01

    The goal of the paper is a discussion of general principle and stages of the optimal analog feedback communication systems (AFCS) design. Previous research devoted to the analysis of particularities of AFCS functioning gave necessary analytical basis for transition to practical design of optimal AFCS. This is new class of communication systems (CS) transmitting the signals, under given bit error rate (BER), with bit rate equal to the capacity of the forward channel and power-bandwidth efficiency attaining the theoretical limit. In the paper, we describe the ordered sequence of the stages of transition from the abstract results to designing of the pre-commercial versions of optimal AFCS considering them as the basic communication link "sensor node (SN)" - "base station" (BS) of the wireless sensor network (WSN). We also show that verified theoretical results enable analytically argued decision making at different stages of designing of the high quality and energy efficient WSN communication links. This facilitates optimisation of the project works schedule, distribution of the tasks and resources for their realization, reduce the time and cost of design.

  19. Systems reliability evaluation under aging by the device of stages optimized through genetic algorithms

    A methodology is developed based on the method of stages optimized through genetic algorithms to allow reliability evaluation of plant stand by systems. This methodology allows the transformation of on-Markovian models into equivalent Markovian ones by considering a set of fictitious states, called stages. Therefore, a state with a time-dependent transition rate is represented by a combination of stages (series, parallel or series/parallel) with constant transition rate. The optimization is necessary to overlap the difficulties presented to find the identification parameter of the device of stages, which is a complex optimization problem and requires a robust and efficient optimization tool, e.g the genetic algorithms. results concerning initial applications to Auxiliary Feedwater Systems (AFW) pumps are shown and commented, for which Weibull and lognormal distribution are employed respectively for modeling failures and repair times. (author)

  20. The energy transition

    This special dossier about energy transition is made of 10 contributions dealing with: thousands of years of energy transition (Jean-Marc Jancovici); a recurring problem after a thousand years of fight (Mathieu Arnoux); urban mobility: another energy story (Arnaud Passalacqua); an opportunity subjected to conditions for the French competitiveness (Dominique Auverlot, Benoit Leguet); Germany: an energy utopia or a role model? (Etienne Beeker); environment: the financing stakes (Dominique Dron); reconciling the economical, social and ecological stakes (Alain Grandjean); Sweden in the face of transportation challenge (Julien Morel, Quentin Lambert); India and China with a commitment to global warming (Jean-Pascal Tranie); training the energy transition managers (Dominique Bureau)

  1. Martensitic phase transitions

    Petry, W.; Neuhaus, J. [Techn. Universitaet Muenchen, Physik Department E13, Munich (Germany)

    1996-11-01

    Many elements transform from a high temperature bcc phase to a more dense packed temperature phase. The great majority of these transitions are of 1st order, displacive and reconstructive. The lattice potentials which govern these martensitic transitions can be probed by inelastic neutron scattering, thereby answering fundamental questions like : Will the transition be announced by dynamical or static fluctuations? What are the trajectories for the displacements needed for the transformation? Does the vibrational entropy stabilize the high temperature phase? Are the unusual transport properties in these materials related to their ability to transform? (author) 17 figs., 1 tab., 46 refs.

  2. Deforming Geometric Transitions

    Rossi, Michele

    2013-01-01

    After a quick review of the wild structure of the complex moduli space of Calabi-Yau threefolds and the role of geometric transitions in this context (the Calabi-Yau web) the concept of "deformation equivalence" for geometric transitions is introduced to understand the arrows of the Gross-Reid Calabi-Yau web as deformation-equivalence classes of geometric transitions. Then the focus will be on some results and suitable examples to understand under which conditions it is possible to get "simpl...

  3. Identification of Paralogous Life-Cycle Stage Specific Cytoskeletal Proteins in the Parasite Trypanosoma brucei

    Neil Portman; Keith Gull

    2014-01-01

    The life cycle of the African trypanosome Trypanosoma brucei, is characterised by a transition between insect and mammalian hosts representing very different environments that present the parasite with very different challenges. These challenges are met by the expression of life-cycle stage-specific cohorts of proteins, which function in systems such as metabolism and immune evasion. These life-cycle transitions are also accompanied by morphological rearrangements orchestrated by microtubule ...

  4. Two Stage Cadherin Kinetics Require Multiple Extracellular Domains but Not the Cytoplasmic Region*

    Chien, Yuan-Hung; Jiang, Ning; Li, Fang; Zhang, Fang; Zhu, Cheng; Leckband, Deborah

    2007-01-01

    Micropipette manipulation measurements quantified the pre-steady state binding kinetics between cell pairs mediated by Xenopus cleavage stage cadherin. The time-dependence of the intercellular binding probability exhibits a fast forming, low probability binding state, which transitions to a slower forming, high probability state. The biphasic kinetics are independent of the cytoplasmic region, but the transition to the high probability state requires the third extracellular domain EC3. Deleti...

  5. An Observational Perspective of Transitional Disks

    Espaillat, C.; Muzerolle, J.; Najita, J.; Andrews, S.; Zhu, Z.; Calvet, N.; Kraus, S.; Hashimoto, J.; Kraus, A.; D'Alessio, P.

    Transitional disks are objects whose inner disk regions have undergone substantial clearing. The Spitzer Space Telescope produced detailed spectral energy distributions (SEDs) of transitional disks that allowed us to infer their radial dust disk structure in some detail, revealing the diversity of this class of disks. The growing sample of transitional disks also opened up the possibility of demographic studies, which provided unique insights. There now exist (sub)millimeter and infrared images that confirm the presence of large clearings of dust in transitional disks. In addition, protoplanet candidates have been detected within some of these clearings. Transitional disks are thought to be a strong link to planet formation around young stars and are a key area to study if further progress is to be made on understanding the initial stages of planet formation. Here we provide a review and synthesis of transitional disk observations to date with the aim of providing timely direction to the field, which is about to undergo its next burst of growth as the Atacama Large Millimeter/submillimeter Array (ALMA) reaches its full potential. We discuss what we have learned about transitional disks from SEDs, color-color diagrams, and imaging in the (sub)millimeter and infrared. We note the limitations of these techniques, particularly with respect to the sizes of the clearings currently detectable, and highlight the need for pairing broadband SEDs with multi-wavelength images to paint a more detailed picture of transitional disk structure. We review the gas in transitional disks, keeping in mind that future observations with ALMA will give us unprecedented access to gas in disks, and also observed infrared variability pointing to variable transitional disk structure, which may have implications for disks in general. We then distill the observations into constraints for the main disk-clearing mechanisms proposed to date (i.e., photoevaporation, grain growth, and companions) and

  6. Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer

    John Hoff; Lauren Baldwin; Jason Lefringhouse; Edward Pavlik; Rachel Miller; Christopher DeSimone; Frederick Ueland; Thomas Tucker; Richard Kryscio; van Nagell, J. R.

    2014-01-01

    Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC) and SEER institutions. Results. Cytoreduction to no visible disease (P < 0.0001) and complete response to platinum-based chemot...

  7. Dynamic properties of structural transition in iron under uniaxial compression.

    Shao, J L; Duan, S Q; He, A M; Qin, C S; Wang, P

    2009-06-17

    By using molecular dynamics simulations, we have successfully simulated the bcc [Formula: see text] hcp structural transition in single-crystal iron under isothermal compression along the [001] direction. The results reveal a distinct softening of C(33) and a hardening of C(31) (or C(32)) prior to the transition and an over-relaxation of the stress after transition. Above the critical stress the morphology evolution of structural transition is analyzed, which can be divided into four stages: hcp homogeneously nucleated, columnar grains formed, nuclei competed and merged, and a laminar structure formed along {110} planes. Besides, our simulations demonstrate that in mixed phases the hcp phase has negative shear stress and the potential of the hcp phase is higher than the bcc phase, and the shear stress of the system keeps a linear decrease with hcp mass fraction. The effect of temperature on the structural transition is also discussed. PMID:21693955

  8. Dynamic properties of structural transition in iron under uniaxial compression

    Shao, J L; Duan, S Q; He, A M; Qin, C S; Wang, P [Institute of Applied Physics and Computational Mathematics, PO Box 8009, Beijing 100088 (China)], E-mail: shao_jianli@iapcm.ac.cn

    2009-06-17

    By using molecular dynamics simulations, we have successfully simulated the bcc {yields} hcp structural transition in single-crystal iron under isothermal compression along the [001] direction. The results reveal a distinct softening of C{sub 33} and a hardening of C{sub 31} (or C{sub 32}) prior to the transition and an over-relaxation of the stress after transition. Above the critical stress the morphology evolution of structural transition is analyzed, which can be divided into four stages: hcp homogeneously nucleated, columnar grains formed, nuclei competed and merged, and a laminar structure formed along {l_brace}110{r_brace} planes. Besides, our simulations demonstrate that in mixed phases the hcp phase has negative shear stress and the potential of the hcp phase is higher than the bcc phase, and the shear stress of the system keeps a linear decrease with hcp mass fraction. The effect of temperature on the structural transition is also discussed.

  9. Dynamic properties of structural transition in iron under uniaxial compression

    By using molecular dynamics simulations, we have successfully simulated the bcc → hcp structural transition in single-crystal iron under isothermal compression along the [001] direction. The results reveal a distinct softening of C33 and a hardening of C31 (or C32) prior to the transition and an over-relaxation of the stress after transition. Above the critical stress the morphology evolution of structural transition is analyzed, which can be divided into four stages: hcp homogeneously nucleated, columnar grains formed, nuclei competed and merged, and a laminar structure formed along {110} planes. Besides, our simulations demonstrate that in mixed phases the hcp phase has negative shear stress and the potential of the hcp phase is higher than the bcc phase, and the shear stress of the system keeps a linear decrease with hcp mass fraction. The effect of temperature on the structural transition is also discussed.

  10. Commercializing the transfer orbit stage

    Miller, M. W.

    1984-01-01

    Key milestones necessary to establish the transfer orbit stage are examined. The selection of the project concept and synthesis of the company are described followed by an analysis venture capability support and the selection of a major aerospace company as prime contractor. A landmark agreement with NASA sanctioned the commercial TOS concept and provided the critical support necessary to raise the next round of venture capital. Project management and customer commitments are also discussed.

  11. Sleep stages, memory and learning.

    Dotto, L

    1996-01-01

    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does n...

  12. Transition Process and Performance in IT Outsourcing: Evidence from a Field Study and Laboratory Experiments

    V. Tiwari (Vinay)

    2010-01-01

    textabstractIn this dissertation, complementing the strategic and economic studies on interorganizational relationships and IT outsourcing, we focus on the operational execution challenges inherent in these relationships by examining the transition stage, which starts immediately after contract sign

  13. Images of gastric cancer stages

    The present work has the objective to review the importance of the images in the preoperating stage of the gastric cancer. It has been emphasized in the modalities of transabdominal ultrasound as much as endoscopic and TAC since they are most valuable in the stage. Certainly the importance of conventional radiology (gastroduodenal series) is also valuable in the stage of the tumor, specially in considering the depth of the same one. In order to make this overhaul, the recent bibliography was consulted but, specially the published one by Japaneses since they follow a classification and methodology different from the used one in most of the countries that belong to the World-wide Organization of the Health. They made an overhaul of approximately 200 cases of patients who have been diagnosed and treated in the Center of Detection of Gastric Cancer of Cartago. In each case review the file, radiological, sonographic and pathological studies, and the cases were chosen that better illustrated the exposed subjects. (Author)

  14. MR staging of endometrial carcinoma

    Biopsy is the technique of choice for the definitive diagnosis of endometrial carcinoma. Since lymphatic tumor spread has been demonstrated to depend on the degree of myometrial involvement, the definition of the latter with imaging techniques may significantly affect both pfognosis and therapy. We investigated, by means of MR imaging at 0.5 T, 14 patients with endometrial carcinoma, to assess both tumor stage and myometrial involvement. FIGO staging system was employed, and M parameter evaluated (M0= no myometrial involvement; M1involvement confined to the inner third; M2= Involvement confined to the middle third; M3= involvement of the whole myometrium). Another parameter was the characteristic high signal of the tumor on PD and T2W images. The patients were then operated and MR information was correlated with surgical findings. Overall diagnostic accuracy of MR imaging was 85.7% in tumor staging, and 92.2% in defining M parameter. Tumor spread into adnexa and into cervical canal was poorly demonstrated by MR imaging

  15. Temperature Influences Selective Mortality during the Early Life Stages of a Coral Reef Fish

    Rankin, Tauna L.; Su Sponaugle

    2011-01-01

    For organisms with complex life cycles, processes occurring at the interface between life stages can disproportionately impact survival and population dynamics. Temperature is an important factor influencing growth in poikilotherms, and growth-related processes are frequently correlated with survival. We examined the influence of water temperature on growth-related early life history traits (ELHTs) and differential mortality during the transition from larval to early juvenile stage in sixteen...

  16. Phase Transitions in Neutron Stars

    Heiselberg, Henning; Hnorth-Jensen, Morten

    1998-01-01

    Phase transitions in neutron stars due to formation of quark matter, kaon condensates, etc. are discussed with particular attention to the order of these transitions. Observational consequences of phase transitions in pulsar angular velocities are examined.

  17. Melting of Transition Metals

    Ross, M; Japel, S; Boehler, R

    2005-04-11

    We review the transition melting studies carried out at Mainz, and describe a recently developed model used to explain that the relatively low melting slopes are due to the partially filled d-bands, and the persistence of the pressure induced s-d transition. The basic tenets of the model have now been reconfirmed by new measurements for Cu and Ni. The measurements show that Cu which has a filled 3d-band, has a melt slope that is about 2.5 greater than its neighbor Ni. In the case of Mo, the apparent discrepancy of DAC melting measurements with shock melting can be explained by accounting for the change in melt slope due to the bcc-cp transition observed in the shock studies. The Fe melt curve is revisited. The possible relevance of the Jahn-Teller effect and recently observed transition metal melts with Icosahedral Short-Range Order (ISRO) is discussed.

  18. Phase transitions modern applications

    Gitterman, Moshe

    2014-01-01

    This book provides a comprehensive review of the theory of phase transitions and its modern applications, based on the five pillars of the modern theory of phase transitions i.e. the Ising model, mean field, scaling, renormalization group and universality. This expanded second edition includes, along with a description of vortices and high temperature superconductivity, a discussion of phase transitions in chemical reaction and moving systems. The book covers a close connection between phase transitions and small world phenomena as well as scale-free systems such as the stock market and the Internet. Readership: Scientists working in different fields of physics, chemistry, biology and economics as well as teaching material for undergraduate and graduate courses.

  19. Generalizing smooth transition autoregressions

    Chini, Emilio Zanetti

    We introduce a variant of the smooth transition autoregression - the GSTAR model - capable to parametrize the asymmetry in the tails of the transition equation by using a particular generalization of the logistic function. A General-to-Specific modelling strategy is discussed in detail, with part......We introduce a variant of the smooth transition autoregression - the GSTAR model - capable to parametrize the asymmetry in the tails of the transition equation by using a particular generalization of the logistic function. A General-to-Specific modelling strategy is discussed in detail...... forecasting experiment to evaluate its point and density forecasting performances. In all the cases, the dynamic asymmetry in the cycle is efficiently captured by the new model. The GSTAR beats AR and STAR competitors in point forecasting, while this superiority becomes less evident in density forecasting...

  20. Transition, Economics of

    Švejnar, Jan

    1st ed. Oxford : Elsevier, 2001 - (Smelser, N.; Baltes, P.), s. 15856-15857 ISBN 0-08-043076-7 Institutional research plan: CEZ:AV0Z7085904 Keywords : economics * transition Subject RIV: AH - Economics

  1. Oligocyclopentadienyl transition metal complexes

    de Azevedo, Cristina G.; Vollhardt, K. Peter C.

    2002-01-18

    Synthesis, characterization, and reactivity studies of oligocyclopentadienyl transition metal complexes, namely those of fulvalene, tercyclopentadienyl, quatercyclopentadienyl, and pentacyclopentadienyl(cyclopentadienyl) are the subject of this account. Thermal-, photo-, and redox chemistries of homo- and heteropolynuclear complexes are described.

  2. Transitivity on Weierstrass points

    Laing, Zoe

    2010-01-01

    We look for Riemann surfaces whose automorphism group acts transitively on the Weierstrass points. We concentrate on hyperelliptic surfaces, surfaces with PSL(2, q) as automorphism group, Platonic surfaces and Fermat curves.

  3. The SAT phase transition

    许可; 李未

    1999-01-01

    Phase transition is an important feature of SAT problem. For random k-SAT model, it is proved that as r(ratio of clauses to variables) increases, the structure of solutions will undergo a sudden change like satisfiability phase transition when r reaches a threshold point (r=rcr). This phenomenon shows that the satisfying truth assignments suddenly shift from being relatively different from each other to being very similar to each other.##属性不符

  4. Stateless Transitive Signature Schemes

    MA Chun-guang; CAI Man-chun; YANG Yi-xian

    2004-01-01

    A new practical method is introduced to transform the stateful transitive signature scheme to stateless one without the loss of security. According to the approach, two concrete stateless transitive signature schemes based on Factoring and RSA are presented respectively. Under the assumption of the hardness of factoring and one-more- RSA-inversion problem, both two schemes are secure under the adaptive chosen-message attacks in random oracle model.

  5. Artificial Intelligence in Transition

    Hart, Peter E.

    1984-01-01

    In the past fifteen years artificial intelligence has changed from being the preoccupation of a handful of scientists to a thriving enterprise that has captured the imagination of world leaders and ordinary citizens alike. While corporate and government officials organize new projects whose potential impact is widespread, to date few people have been more affected by the transition than those already in the field. I review here some aspects of this transition, and pose some issues that it rai...

  6. The WFCAM Transit Survey

    Hodgkin S.

    2011-02-01

    Full Text Available The WFCAM Transit Survey (WTS has been obtaining data on the United Kingdom Infrared Telescope since 2007. The WTS targets about 8,000 M dwarfs over several square degrees of sky, and aims to find low-mass eclipsing binaries and planets, down to the size of the Earth, transiting M dwarf stars with periods up to a few days.

  7. Transitions in Energy Use

    Grubler, A.

    2004-01-01

    Patterns of energy use have changed dramatically since the onset of the industrial revolution in terms of both energy quantities and energy quality. These changing patterns of energy use, where energy quantities and quality interact in numerous important ways, are referred to in this article as energy transitions and are described from a historical perspective as well as through future scenarios. Far from being completed, many of these transitions are continuing to unfold in industrial and de...

  8. Pinocchio: Geppetto's transitional object

    Gabriele Zeloni

    2015-01-01

    The literature has been considered by Freud and others after him, a form of unaware exploration of mind that can leads to discoveries similar to psychoanalysis’s discoveries. From this perspective, the author puts forward the following hypothesis: Pinocchio is a puppet who comes to life and is therefore, from a child's perception, a transitional object according to Winnicott. Consequently Geppetto is nothing more than the involuntary representation of any child interacting with the transition...

  9. Map Projection Transitions

    Nedjeljko Frančula; Miljenko Lapaine

    2013-01-01

    Map Projection Transitions is a very successful web application about map projections. The web page (http://www.jasondavies.com/maps/transition) pre­sents a world map with graticule and country borders in the oblique Aitoff projection, with the South Pole. The map is not static, but animated. The South Pole moves toward the bottom and Earth rotates around its poles. The animation lasts five seconds, after which the projection changes and movement continues for five seconds, after which the pr...

  10. Quarkonia and their transitions

    Eichten, E; Mahlke, H; Rosner, J L; Eichten, Estia; Godfrey, Stephen; Mahlke, Hanna; Rosner, Jonathan L.

    2007-01-01

    Valuable data on quarkonia (the bound states of a heavy quark Q=c,b and the corresponding antiquark) have recently been provided by a variety of sources, mainly e+ e- collisions, but also hadronic interactions. This permits a thorough updating of the experimental and theoretical status of electromagnetic and strong transitions in quarkonia. We discuss QQbar transitions to other QQbar states, with some reference to processes involving QQbar annihilation.

  11. Transition and Financial Collapse

    1995-01-01

    One of the many problems facing the countries in transition from socialism to capitalism after the initial phase of privatization and restructuring is the lack of proven entrepreneurial talent in addition to a low initial level of capital. New entrepreneurs might find it hard to finance their start-up enterprises. This paper therefore argues that a financial collapse and thus a collapse of the new entrepreneurial sector might occur. First, the lack of financial intermediation in transition ec...

  12. The Three Stages of Teaching Reading

    郝禹

    2005-01-01

    If we want to improve our way of teaching, one way is to teach reading in three stages: Pre- reading stage, while-reading stage, and post- reading stage. Each stage has a different goal and deals with different reading strategies. Prereading means before the text is read. In while reading stage, we have looked at the main reading skills: skimming, scanning , reading for detail , drawing inferences about the author's purpose and intention. Post - reading stage mainly focuses on the exploitation of the text. It aims to help the reader understand the content and structure of the text, as well as the author's purpose in writing it.

  13. Facility transition instruction

    The Bechtel Hanford, Inc. facility transition instruction was initiated in response to the need for a common, streamlined process for facility transitions and to capture the knowledge and experience that has accumulated over the last few years. The instruction serves as an educational resource and defines the process for transitioning facilities to long-term surveillance and maintenance (S and M). Generally, these facilities do not have identified operations missions and must be transitioned from operational status to a safe and stable configuration for long-term S and M. The instruction can be applied to a wide range of facilities--from process canyon complexes like the Plutonium Uranium Extraction Facility or B Plant, to stand-alone, lower hazard facilities like the 242B/BL facility. The facility transition process is implemented (under the direction of the US Department of Energy, Richland Operations Office [RL] Assistant Manager-Environmental) by Bechtel Hanford, Inc. management, with input and interaction with the appropriate RL division and Hanford site contractors as noted in the instruction. The application of the steps identified herein and the early participation of all organizations involved are expected to provide a cost-effective, safe, and smooth transition from operational status to deactivation and S and M for a wide range of Hanford Site facilities

  14. The Institutional Foundations of Market Transition in the People's Republic of China

    Qian, Yingyi

    2000-01-01

    This paper intends to properly account for the People’s Republic of China’s (PRC) two decades of market transition by examining its institutional foundations. The journey of transition is analyzed as a two-stage process. In the first stage (1978-93), the system was reformed to unleash the standard market forces of incentives, hard budget constraints, and competition. The underlying institutional forms and mechanisms, however, were far from conventional: reforming government through regional d...

  15. The Neglected Dimension of Commercial Liberalism: Economic Cooperation and Transition to Peace

    Galia Press-Barnathan

    2006-01-01

    This article examines the role of economic factors in facilitating the transition to peace between former enemies. It examines a less developed angle of the commercial liberalism approach, namely, when and how economic incentives can play a positive role in the process of building peace, rather than the standard focus on how economic interaction can reduce the likelihood of armed conflicts. It does so by distinguishing between two stages in the transition to peace: Stage I of a peace treaty (...

  16. Aspects of dislocation substructures associated with the deformation stages of stainless steel AISI 304 at high temperatures

    The development of dislocation substrutures in type 304 austenitic stainless steel at high temperatures has been associated with the deformation stages through log dσ/d epsilon x log epsilon plots, which show the transition point independently. The mechanisms responsible for the Dynamic Strain Aging particulary the Portevin-LeChatelier effect were related to the appearence of the stages. The results indicate that the deformation stages can be divided into two distinct regions. Each one of these region show particular characteristics with respect to the stress level, transition point, developed substructure and type of crystalline defects interaction with dislocations. (Author)

  17. Stage-Structured Population Dynamics of AEDES AEGYPTI

    Yusoff, Nuraini; Budin, Harun; Ismail, Salemah

    Aedes aegypti is the main vector in the transmission of dengue fever, a vector-borne disease affecting world population living in tropical and sub-tropical countries. Better understanding of the dynamics of its population growth will help in the efforts of controlling the spread of this disease. In looking at the population dynamics of Aedes aegypti, this paper explored the stage-structured modeling of the population growth of the mosquito using the matrix population model. The life cycle of the mosquito was divided into five stages: eggs, larvae, pupae, adult1 and adult2. Developmental rates were obtained for the average Malaysian temperature and these were used in constructing the transition matrix for the matrix model. The model, which was based only on temperature, projected that the population of Aedes aegypti will blow up with time, which is not realistic. For further work, other factors need to be taken into account to obtain a more realistic result.

  18. Lean-rich axial stage combustion in a can-annular gas turbine engine

    Laster, Walter R.; Szedlacsek, Peter

    2016-06-14

    An apparatus and method for lean/rich combustion in a gas turbine engine (10), which includes a combustor (12), a transition (14) and a combustor extender (16) that is positioned between the combustor (12) and the transition (14) to connect the combustor (12) to the transition (14). Openings (18) are formed along an outer surface (20) of the combustor extender (16). The gas turbine (10) also includes a fuel manifold (28) to extend along the outer surface (20) of the combustor extender (16), with fuel nozzles (30) to align with the respective openings (18). A method (200) for axial stage combustion in the gas turbine engine (10) is also presented.

  19. Single conversion stage amplifier - SICAM

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  20. Ares I Upper Stage Fabrication

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California.

  1. Preoperative staging of rectal cancer.

    Smith, Neil; Brown, Gina

    2008-01-01

    Detailed preoperative staging using high resolution magnetic resonance imaging (MRI) enables the selection of patients that require preoperative therapy for tumour regression. This information can be used to instigate neoadjuvant therapy in those patients with poor prognostic features prior to disturbing the tumour bed and potentially disseminating disease. The design of trials incorporating MR assessment of prognostic factors prior to therapy has been found to be of value in assessing treatment modalities and outcomes that are targeted to these preoperative prognostic subgroups and in providing a quantifiable assessment of the efficacy of particular chemoradiation treatment protocols by comparing pre-treatment MR staging with post therapy histology assessment. At present, we are focused on achieving clear surgical margins of excision (CRM) to avoid local recurrence. We recommend that all patients with rectal cancer should undergo pre-operative MRI staging. Of these, about half will have good prognosis features (T1-T3b, N0, EMVI negative, CRM clear) and may safely undergo primary total mesorectal excision. Of the remainder, those with threatened or involved margins will certainly benefit from pre-operative chemoradiotherapy with the aim of downstaging to permit safe surgical excision. In the future, our ability to recognise features predicting distant failure, such as extramural vascular invasion (EMVI) may be used to stratify patients for neo-adjuvant systemic chemotherapy in an effort to prevent distant relapse. The optimal pre-operative treatment regimes for these patients (radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy) is the subject of current and future trials. PMID:17957502

  2. Venus Transit 2004

    Mayo, L. A.; Odenwald, S. F.

    2002-09-01

    December 6th, 1882 was the last transit of the planet Venus across the disk of the sun. It was heralded as an event of immense interest and importance to the astronomical community as well as the public at large. There have been only six such occurrences since Galileo first trained his telescope on the heavens in 1609 and on Venus in 1610 where he concluded that Venus had phases like the moon and appeared to get larger and smaller over time. Many historians consider this the final nail in the coffin of the Ptolemaic, Earth centered solar system. In addition, each transit has provided unique opportunities for discovery such as measurement and refinement of the astronomical unit, calculation of longitudes on the earth, and detection of Venus' atmosphere. The NASA Sun Earth Connection Education Forum in partnership with the Solar System Exploration Forum, DPS, and a number of NASA space missions is developing plans for an international education program centered around the June 8, 2004 Venus transit. The transit will be visible in its entirety from Europe and partially from the East Coast of the United States. We will use a series of robotic observatories including the Telescopes In Education network distributed in latitude to provide observations of the transit that will allow middle and high school students to calculate the A.U. through application of parallax. We will also use Venus transit as a probe of episodes in American history (e.g. 1769: revolutionary era, 1882: post civil war era, and 2004: modern era). Museums and planetariums in the US and Europe will offer real time viewing of the transit and conduct educational programs through professional development seminars, public lectures, and planetarium shows. We are interested in soliciting advice from the research community to coordinate professional research interests with this program.

  3. Electrorheological damper for the ultra-precision air bearing stage

    2008-01-01

    This paper illustrates how the electrorheological damper substantially improves the performance of the ultra-precision air bearing stage.Smart materials such as electrorheological fluids have attracted many researchers' attention because of their resistance changeable performance in different electric fields.Meanwhile,the ultra-precision air bearing stage driven by the linear-motor is characterized by zero mechanical damping and poor anti-disturbance.To solve this problem and consider the characteristics of electrorheological fluids,an electrorheological damper is proposed in this paper.The electrorheological damper's characteristics in high electric fields are obtained based on the Eyring constitutive model,which smoothly transits from the pre-yield to post-yield region.To enhance the performance of the electrorheological damper,which takes effect only when the stage is going to decelerate or position,the on-off and sliding mode control methods design and optimize the controller.The results prove that by using the advanced sliding mode control method,the characteristics of the ultra-precision air bearing stage can be effectively improved through the introduction of the electrorheological damper.

  4. Single Stage Contactor Testing Of The Next Generation Solvent Blend

    Herman, D. T.; Peters, T. B.; Duignan, M. R.; Williams, M. R.; Poirier, M. R.; Brass, E. A.; Garrison, A. G.; Ketusky, E. T.

    2014-01-06

    The Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU) facility at the Savannah River Site (SRS) is actively pursuing the transition from the current BOBCalixC6 based solvent to the Next Generation Solvent (NGS)-MCU solvent to increase the cesium decontamination factor. To support this integration of NGS into the MCU facility the Savannah River National Laboratory (SRNL) performed testing of a blend of the NGS (MaxCalix based solvent) with the current solvent (BOBCalixC6 based solvent) for the removal of cesium (Cs) from the liquid salt waste stream. This testing utilized a blend of BOBCalixC6 based solvent and the NGS with the new extractant, MaxCalix, as well as a new suppressor, tris(3,7dimethyloctyl) guanidine. Single stage tests were conducted using the full size V-05 and V-10 liquid-to-liquid centrifugal contactors installed at SRNL. These tests were designed to determine the mass transfer and hydraulic characteristics with the NGS solvent blended with the projected heel of the BOBCalixC6 based solvent that will exist in MCU at time of transition. The test program evaluated the amount of organic carryover and the droplet size of the organic carryover phases using several analytical methods. The results indicate that hydraulically, the NGS solvent performed hydraulically similar to the current solvent which was expected. For the organic carryover 93% of the solvent is predicted to be recovered from the stripping operation and 96% from the extraction operation. As for the mass transfer, the NGS solvent significantly improved the cesium DF by at least an order of magnitude when extrapolating the One-stage results to actual Seven-stage extraction operation with a stage efficiency of 95%.

  5. Morphogenesis of early stage melanoma

    Chatelain, Clément; Amar, Martine Ben

    2015-08-01

    Melanoma early detection is possible by simple skin examination and can insure a high survival probability when successful. However it requires efficient methods for identifying malignant lesions from common moles. This paper provides an overview first of the biological and physical mechanisms controlling melanoma early evolution, and then of the clinical tools available today for detecting melanoma in vivo at an early stage. It highlights the lack of diagnosis methods rationally linking macroscopic observables to the microscopic properties of the tissue, which define the malignancy of the tumor. The possible inputs of multiscale models for improving these methods are shortly discussed.

  6. Staging of cutaneous malignant melanoma by CT; CT-Staging kutaner maligner Melanome

    Hoffend, J. [Klinikum der Stadt Ludwigshafen gGmbH, Zentralinstitut fuer diagnostische und interventionelle Radiologie, Ludwigshafen (Germany)

    2015-01-30

    Malignant melanomas are a challenge in radiological imaging diagnostics as they may metastasize into every organ and tissue. Cross-sectional imaging, in particular positron emission tomography computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI), are considered the standards in the staging of melanomas. Because of its excellent availability CT, however, remains a widely employed staging modality. Familiarity with the manifold CT morphology of metastasized melanomas as it is described here is essential when interpreting dedicated CT and in addition useful when interpreting PET/CT results. In individual cases CT can assist in the detection of transient metastases. In the detection of locoregional lymph node metastases CT has a median sensitivity and specificity in meta-analyses of at best 61 % and 97 %, respectively, which is inferior to the performance of ultrasound (96 % and 99 %, respectively). According to meta-analyses, in the assessment of systemic tumor spread CT can detect the majority of metastases with a sensitivity and specificity of 51-63 % and 69-78 %, respectively, which is inferior to MRI and PET/CT. Therefore, if an exact staging is required for critical management decisions, MRI or PET/CT should be employed whenever possible. (orig.) [German] Maligne Melanome koennen in praktisch jedes Organ und Gewebe metastasieren und stellen daher eine Herausforderung fuer die radiologische Diagnostik dar. Schnittbildverfahren, bevorzugt PET/CT und MRT, werden heute als Standard in der Ausbreitungsdiagnostik von Melanomen angesehen. Wegen ihrer ubiquitaeren Verfuegbarkeit bleibt jedoch die CT ein vielfach genutztes Staginginstrument. Die Kenntnis der vielfaeltigen CT-Morphologie von Melanommetastasen, wie sie in diesem Beitrag beschrieben wird, ist ueber die dedizierte CT hinaus uebertragbar auf die von der aktuellen Leitlinie bevorzugte Bildgebung mit der PET/CT. Im Einzelfall kann die CT hilfreich bei der Detektion von In-transit

  7. Stages and Effects of Globalization

    Modest Boiciuc Dănuț

    2009-06-01

    Full Text Available The globalization process started in the late twentieth century, of international tradedevelopment fund, has experienced major pulses over the last century, but non the size of the thirdwave of globalization triggered by the world’s transition to democracy and market economy. Thetransition speed of the global economy at the turn of two millennia was unimaginable a half centuryago. The political, economical, technological, psychological, cultural mega-trends managed toradically change the world in recent decades. Globalization has become the burning issue of our time,being not only a process but a real phenomenon of continuous transition to a new development model.Many fear that the new economic conditions induced by globalization will lead to increased poverty,job losses; others fear the spread of epidemics or incurable diseases. There are many people who fearthat human activity will irreparably damage the environment on which depends our own existence.The future threats have one thing in common: they do not respect national borders. Even the biggestcountries in the world cannot protect its citizens against these threats. More than ever in humanhistory, we must share the common destiny of globalization.

  8. Weber numbers at various stages of water projectile transformation during free fall in air

    Volkov, R. S.; Kuznetsov, G. V.; Kuibin, P. A.; Strizhak, P. A.

    2015-10-01

    The process of breakage of water projectiles (spherical "balls" with initial volumes ranging within 0.05-40.5 L) during free fall in air from a height of 3 m has been studied by means of high-speed (up to 105 fps) video recording. Four stages of projectile transformation are distinguished that precede the formation of a cloud of droplets. It is established that the transitions from one stage to another proceed within shorter fall times for greater initial volumes of water. Weber numbers at these stages are determined.

  9. Responses to Change Helping People Make Transitions

    (CCL), Center for Creative Leadership

    2011-01-01

    The ongoing state of many organizations is one of change. People who experience major change tend to exhibit one of four patterns of response: entrenched, overwhelmed, poser, or learner. As a leader, you need to understand the patterns of response that people express and to customize intervention strategies to help them make the transition. People can pass through a given response stage and move to one that is more effective--especially if you provide timely intervention and support. This guidebook will help you understand how people, including yourself, are responding to change and what you c

  10. The Juvenile Transition: A Developmental Switch Point in Human Life History

    Del Giudice, Marco; Angeleri, Romina; Manera, Valeria

    2009-01-01

    This paper presents a new perspective on the transition from early to middle childhood (i.e., human juvenility), investigated in an integrative evolutionary framework. Juvenility is a crucial life history stage, when social learning and interaction with peers become central developmental functions; here it is argued that the "juvenile transition"…

  11. Improving transition between power optimization and power limitation of variable speed/variable pitch wind turbines

    Hansen, A.D.; Bindner, H. [Risoe National Lab., Wind Energy and Atmospheric Physics Dept., Roskilde (Denmark); Rebsdorf, A. [Vestas Wind Systems A/S, Lem (Denmark)

    1999-03-01

    The paper summarises and describes the main results of a recently performed study of improving the transition between power optimization and power limitation for variable speed/variable pitch wind turbines. The results show that the capability of varying the generator speed also can be exploited in the transition stage to improve the quality of the generated power. (au)

  12. Emerging versus Emancipating: The Transition to Adulthood for Youth in Foster Care

    Berzin, Stephanie Cosner; Singer, Erin; Hokanson, Kimberly

    2014-01-01

    Emerging adulthood has been defined as a distinct developmental stage in which youth experience opportunities for identity development and transition toward independence. While this period has been examined for youth in the general population, less is known about how foster youth experience this transition. This study uses qualitative interviews…

  13. Examining hydrogen transitions.

    Plotkin, S. E.; Energy Systems

    2007-03-01

    This report describes the results of an effort to identify key analytic issues associated with modeling a transition to hydrogen as a fuel for light duty vehicles, and using insights gained from this effort to suggest ways to improve ongoing modeling efforts. The study reported on here examined multiple hydrogen scenarios reported in the literature, identified modeling issues associated with those scenario analyses, and examined three DOE-sponsored hydrogen transition models in the context of those modeling issues. The three hydrogen transition models are HyTrans (contractor: Oak Ridge National Laboratory), MARKAL/DOE* (Brookhaven National Laboratory), and NEMS-H2 (OnLocation, Inc). The goals of these models are (1) to help DOE improve its R&D effort by identifying key technology and other roadblocks to a transition and testing its technical program goals to determine whether they are likely to lead to the market success of hydrogen technologies, (2) to evaluate alternative policies to promote a transition, and (3) to estimate the costs and benefits of alternative pathways to hydrogen development.

  14. Noise and Phase Transitions

    Chen, Zhi; Yu, Clare C.

    2006-03-01

    Noise is present in many physical systems and is often viewed as a nuisance. Yet it can also be a probe of microscopic fluctuations. There have been indications recently that the noise in the resistivity increases in the vicinity of the metal-insulator transition. But what are the characteristics of the noise associated with well-understood first and second order phase transitions? It is well known that critical fluctuations are associated with second order phase transitions, but do these fluctuations lead to enhanced noise? We have addressed these questions using Monte Carlo simulations to study the noise in the 2D Ising model which undergoes a second order phase transition, and in the 5-state Potts model which undergoes a first order phase transition. We monitor these systems as the temperature drops below the critical temperature. At each temperature, after equilibration is established, we obtain the time series of quantities characterizing the properties of the system, i.e., the energy and magnetization per site. We apply different methods, such as the noise power spectrum, the Detrended Fluctuation Analysis (DFA) and the second spectrum of the noise, to analyze the fluctuations in these quantities.

  15. Sleep stages, memory and learning.

    Dotto, L

    1996-04-15

    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does not produce memory deficits. Declarative memory, which is used for the recall of specific facts, is not similarly affected by REM-sleep loss. The learning of procedural motor tasks, including those required in many sports, is impaired by the loss of stage 2 sleep, which occurs primarily in the early hours of the morning. These findings have implications for the academic and athletic performance of students and for anyone whose work involves ongoing learning and demands high standards of performance. PMID:8612256

  16. Initial Stages of the Pyrolysis of Polyethylene.

    Popov, Konstantin V; Knyazev, Vadim D

    2015-12-10

    An experimental study of the kinetics of the initial stages of the pyrolysis of high-density polyethylene (PE) was performed. Quantitative yields of gas-phase products (C1-C8 alkanes and alkenes) and functional groups within the remaining polyethylene melt (methyl, vinyl, vinylene, vinylidene, and branching sites) were obtained as a function of time (0-20 min) at five temperatures in the 400-440 °C range. Gas chromatography and NMR ((1)H and (13)C) were used to detect the gas- and condensed-phase products, respectively. Modeling of polyethylene pyrolysis was performed, with the primary purpose of determining the rate constants of several critical reaction types important at the initial pyrolysis stages. Detailed chemical mechanisms were created (short and extended mechanisms) and used with both the steady-state approximation and numerical integration of the differential kinetic equations. Rate constants of critical elementary reactions (C-C backbone scission, two kinds of H-atom transfer, radical addition to the double bond, and beta-scission of tertiary alkyl radicals) were adjusted, resulting in an agreement between the model and the experiment. The values of adjusted rate constants are in general agreement with those of cognate reactions of small molecules in the gas phase, with the exception of the rate constants of the backbone C-C scission, which is found to be approximately 1-2 orders of magnitude lower. This observation provides tentative support to the hypothesis that congested PE melt molecular environment impedes the tumbling motions of separating fragments in C-C bond scission, thus resulting in less "loose" transition state and lower rate constant values. Sensitivity of the calculations to selected uncertainties in model properties was studied. Values and estimated uncertainties of four combinations of rate constants are reported as derived from the experimental results via modeling. The dependence of the diffusion-limited rate constant for radical

  17. State Transition Algorithm

    Zhou, Xiaojun; Gui, Weihua

    2012-01-01

    In terms of the concepts of state and state transition, a new heuristic random search algorithm named state transition algorithm is proposed. For continuous function optimization problems, four special transformation operators called rotation, translation, expansion and axesion are designed. Adjusting measures of the transformations are mainly studied to keep the balance of exploration and exploitation. Convergence analysis is also discussed about the algorithm based on random search method. In the meanwhile, to strengthen the search ability in high dimensional space, communication strategy is introduced into the basic algorithm and intermittent exchange is presented to prevent premature convergence. Finally, experiments are carried out for the algorithms. With 10 common benchmark unconstrained continuous functions used to test the performance, the results show that state transition algorithms are promising algorithms due to their good global search capability and convergence property when compared with some ...

  18. To finance the transition

    A set of brief articles illustrates the emergence of innovating and operational financing tools aimed at supporting energy transition in France and in Europe. As far as France is concerned, different examples are evoked: raising local savings, crowd-funding for renewable energies, citizen investment, cooperation between industries, communities and citizens, a semi-public company with citizen participation, the case of the Nancy urban community, a joint experience by a local public company and an investment fund. As far as Europe is concerned, the following topics or examples are evoked: local policies as lever for European financing, the Danish example of citizen-based financing, crowd-funding in the UK, the European emergence of cooperatives. As far as banks and institutions are concerned, the following topics are addressed: tools implemented by the Caisse des Depots for energy transition, the roles of banks and of public institutions in the financing of energy transition

  19. Transition to the Cloud

    Hedman, Jonas; Xiao, Xiao

    2016-01-01

    The rising of cloud computing has dramatically changed the way software companies provide and distribute their IT product and related services over the last decades. Today, most software is bought offthe-shelf and distributed over the Internet. This transition is greatly influencing how software...... companies operate. In this paper, we present a case study of an ERP vendor for SMB (small and mediumsize business) in making a transition towards a cloud-based business model. Through the theoretical lens of ecosystem, we are able to analyze the evolution of the vendor and its business network as a whole......, and find that the relationship between vendor and Value-added-Reseller (VAR) is greatly affected. We conclude by presenting critical issues and challenges for managing such cloud transition....

  20. Gender Inequalities in the School-to-Work Transition in Europe. Short Statistical Report No. 4

    Mills, Melinda; Präg, Patrick

    2014-01-01

    The school-to-work transition is a crucial life stage for young people, and research has often shown that this stage has important effects on their entire life courses. In recent years, young people willing to enter the labour market have been challenged by increasing uncertainty and comparatively high unemployment. These labour market trends have…

  1. Electroweak phase transitions

    An analytic treatment of the one Higgs doublet, electroweak phase transition is given. The phase transition is first order, occurs by the nucleation of thin walled bubbles and completes at a temperature where the order parameter, left-angle φ right-angle T is significantly smaller than it is when the origin becomes absolutely unstable. The rate of anomalous baryon number violation is an exponentially function of left-angle φ right-angle T. In very minimal extensions of the standard model it is quite easy to increase left-angle φ right-angle T so that anomalous baryon number violation is suppressed after completion of the phase transition. Hence baryogenesis at the electroweak phase transition is tenable in minimal of the standard model. In some cases additional phase transitions are possible. For a light Higgs boson, when the top quark mass is sufficiently large, the state where the Higgs field has a vacuum expectation value left-angle φ right-angle = 246 GeV is not the true minimum of the Higgs potential. When this is the case, and when the top quark mass exceeds some critical value, thermal fluctuations in the early universe would have rendered the state left-angle φ right-angle = 246 GeV unstable. The requirement that the state left-angle φ right-angle = 246 GeV is sufficiently long lived constrains the masses of the Higgs boson and the top quark. Finally, we consider whether local phase transitions can be induced by heavy particles which act as seeds for deformations in the scalar field

  2. Properties of transition radiation

    Several fundamental electromagnetic problems associated with the transition radiation accompanying the passage of charged particles through perfectly conducting planar surfaces are investigated. For a charge of uniform but arbitrary velocity incident normally on a grounded, infinitely conducting plane, the exact transition fields are obtained, allowing a detailed analysis of both the radiation distribution and associated transition events. The radiation in this case is also computed by both direct integration of the constructed surface current, and the 'pair annihilation' interpretation of the problem. Subsequent investigation of the electromagnetic annihilation of charge allows establishment of the 'annihilation radiation theorem' relating charge self-energy to annihilation energy. The problem of the radiation loss due to a charge passing through a hole in the plane is then formulated and solved by 'interpolating' between the computed nonrelativistic and existing ultra-relativistic solutions. For nonrelativistic motion, the presence of the source charge is found to induce an infinite number of image multipoles contained within a diameter of the hole, whose associated bramsstrahlung gives rise to the transition radiation of the source. Application of the interpolation formula allows construction of a temperature dependent radiation loss expression appropriate to the passage of a relativistic beam pulse through an aperture. A formula is also developed for the radiation loss suffered by a finite length beam passing through the hole, and employed in estimating the transition radiation losses in the 200-MeV proton LINAC at NAL. Finally, the anomalous intensity peaks due to 'edge waves' appearing in the Fresnel-like diffraction patterns of electron micrographs are investigated qualitatively in connection with the transition radiation associated with the electron beam's traversal of the specimen

  3. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    WANG PengFei; FU JianHua; MA WanYun; CHEN DieYan; Lü DanYu; BAI WenJia

    2009-01-01

    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage,which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  4. Comparative Analysis of Sequence Characteristics among Different Superimposed Stages of the Chelif Basin, Algeria

    ZHANG Yuanfu; JIANG Zaixing; WANG Yue; BAO Dandan

    2009-01-01

    Superimposed basins were investigated with respect to tectonic evolution, sediment deposition and petroleum characteristics within a single superposition stage generally. The comparative study was seldom seen. Sequence characteristics were compared for two different superimposed stages-an expanding rifting stage and a depression-foreland transition stage-in the Chelif Basin during the Miocene in this paper. A model and mechanism for sequence evolution of superimposed basins in different dynamic situations are discussed with respect to sequence similarities and differences. The compared characters include sequence thickness, sequence boundaries and system tracts, as well as sediment deposition within sequences and sequence development patterns. Finally, some typical features of sequence development concomitant with changes of superimposed stages in the Chelif Basin are discussed.

  5. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    2009-01-01

    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  6. UTM: Universal Transit Modeller

    Deeg, Hans J.

    2014-12-01

    The Universal Transit Modeller (UTM) is a light-curve simulator for all kinds of transiting or eclipsing configurations between arbitrary numbers of several types of objects, which may be stars, planets, planetary moons, and planetary rings. A separate fitting program, UFIT (Universal Fitter) is part of the UTM distribution and may be used to derive best fits to light-curves for any set of continuously variable parameters. UTM/UFIT is written in IDL code and its source is released in the public domain under the GNU General Public License.

  7. Transition - the energy 'mercato'

    As chairmen and governance mode of EDF, GDF Suez, AREVA and CEA are about to change, this article proposes an overview of the main challenges faced by these companies regarding energy transition in a context of energy market deregulation, massive development of renewable energies (as specified in the law on energy transition), drastic changes dues to the exploitation of shale gases, new models of financing of nuclear energies, and stagnant consumption. The author gives a brief overview of the main challenges for EDF, AREVA and GDF Suez, and briefly presents Jean-Bernard Levy, the new EDF chairman

  8. Parametric modal transition systems

    Beneš, Nikola; Křetínský, Jan; Larsen, Kim Guldstrand; Møller, M.H.; Srba, J.

    2011-01-01

    Modal transition systems (MTS) is a well-studied specification formalism of reactive systems supporting a step-wise refinement methodology. Despite its many advantages, the formalism as well as its currently known extensions are incapable of expressing some practically needed aspects in the...... refinement process like exclusive, conditional and persistent choices. We introduce a new model called parametric modal transition systems (PMTS) together with a general modal refinement notion that overcome many of the limitations and we investigate the computational complexity of modal refinement checking....

  9. Electronic phase transitions

    Kopaev, YuV

    1992-01-01

    Electronic Phase Transitions deals with topics, which are presently at the forefront of scientific research in modern solid-state theory. Anderson localization, which has fundamental implications in many areas of solid-state physics as well as spin glasses, with its influence on quite different research activities such as neural networks, are two examples that are reviewed in this book. The ab initio statistical mechanics of structural phase transitions is another prime example, where the interplay and connection of two unrelated disciplines of solid-state theory - first principle ele

  10. Pinocchio: Geppetto's transitional object

    Gabriele Zeloni

    2015-01-01

    Full Text Available The literature has been considered by Freud and others after him, a form of unaware exploration of mind that can leads to discoveries similar to psychoanalysis’s discoveries. From this perspective, the author puts forward the following hypothesis: Pinocchio is a puppet who comes to life and is therefore, from a child's perception, a transitional object according to Winnicott. Consequently Geppetto is nothing more than the involuntary representation of any child interacting with the transitional object. The author explains the results of the analysis of the text in support of the hypothesis and reflects on the impact of The adventure of Pinocchio on the reader.

  11. A Three-Stage Mechanistic Model for Ammonia Borane Dehydrogenation by Shvo’s Catalyst

    Lu, Zhiyao; Conley, Brian L.; Williams, Travis J.

    2012-01-01

    We propose a mechanistic model for three-stage dehydrogenation of ammonia borane (AB) catalyzed by Shvo’s cyclopentadienone-ligated ruthenium complex. We provide evidence for a plausible mechanism for catalyst deactivation, the transition from fast catalysis to slow catalysis, and relate those findings to the invention of a second-generation catalyst that does not suffer from the same deactivation chemistry.

  12. An Overview of Markov Chain Methods for the Study of Stage-Sequential Developmental Processes

    Kapland, David

    2008-01-01

    This article presents an overview of quantitative methodologies for the study of stage-sequential development based on extensions of Markov chain modeling. Four methods are presented that exemplify the flexibility of this approach: the manifest Markov model, the latent Markov model, latent transition analysis, and the mixture latent Markov model.…

  13. Piperazine pivoted transition metal dithiocarbamates

    Khan, Sadaf; Nami, Shahab A. A.; Siddiqi, K. S.

    2008-03-01

    A quadridentate ligand disodium bis(2,2'-dithiopiperazinato-2,2'-diamino diethylamine) Na 2L 2 and its self assembled transition metal complexes of the type, M 2(L 2) 2 {M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)} have been reported. The piperazine pivoted homodinuclear complexes have been characterized by a range of spectral, thermal, microanalytical and conductometric techniques. On the basis of IR and 1HNMR data a symmetrical bidentate coordination of the dithiocarbamato moiety has been observed in all the cases. The TGA profile of the ligand exhibits two stage thermolytic pattern although the complexes decompose in three steps, respectively. Metal sulfide is found to be the end product. The formation of homodinuclear complexes has been ascertained on the basis of FAB mass spectral data and a probable fragmentation pattern has been proposed. On the basis of UV-visible spectroscopic results and room temperature magnetic moment data a tetrahedral geometry has been proposed for all the complexes except for the Ni(II) and Cu(II) which are found to be square-planar.

  14. Development perspective of transitional countries

    Ilić Bogdan B.

    2005-01-01

    Full Text Available The end of 20th century witnessed the affirmation and development of information technology as well as the transformation of industrial into information, "new economy", which caused changes in people and circumstances. The role and importance of nonhuman factors was increased, causing entrepreneurship and knowledge-based information to become the most significant resources. The Internet became the basis of the "new economy". It changes the way of doing business, studying, researching, communicating and competition. It also reduces operating costs, crosses national borders and leads to the globalization of the world economy. Transitional countries have to fit into modern development flows by formulating their own strategy of national development and establishing their own competitive advantages in conditions of "new economy". These advantages lie predominantly in highly qualified and skilled younger labor which learns fast and adopts new knowledge and skills, through reducing transactional costs, shortening of certain development stages through which developed countries have already gone, using their experience, scientific-technological progress, a rise in work productivity, etc. Experience of other countries should be innovated and adapted to one's own material and social conditions, not copied. This enables the emergence of "European small tigers", which are similar to "Asian small tigers".

  15. Second Stage Turbine Bucket Airfoil.

    Xu, Liming; Ahmadi, Majid; Humanchuk, David John; Moretto, Nicholas; Delehanty, Richard Edward

    2003-05-06

    The second-stage buckets have airfoil profiles substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in inches in Table I wherein Z is a perpendicular distance from a plane normal to a radius of the turbine centerline and containing the X and Y values with the Z value commencing at zero in the X, Y plane at the radially innermost aerodynamic section of the airfoil and X and Y are coordinate values defining the airfoil profile at each distance Z. The X, Y and Z values may be scaled as a function of the same constant or number to provide a scaled-up or scaled-down airfoil section for the bucket.

  16. Early stages of Ostwald ripening

    Shneidman, Vitaly A.

    2013-07-01

    The Becker-Döring (BD) nucleation equation is known to predict a narrow double-exponential front (DEF) in the distribution of growing particles over sizes, which is due to early transient effects. When mass conservation is included, nucleation is eventually exhausted while independent growth is replaced by ripening. Despite the enormous difference in the associated time scales, and the resulting demand on numerics, within the generalized BD model the early DEF is shown to be crucial for the selection of the unique self-similar Lifshitz-Slyozov-Wagner asymptotic regime. Being preserved till the latest stages of growth, the DEF provides a universal part of the initial conditions for the ripening problem, regardless of the mass exchange mechanism between the nucleus and the matrix.

  17. The Nuclear Cryogenic Propulsion Stage

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Borowski, Stanley K.; Scott, John

    2014-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP). Nuclear propulsion can be affordable and viable compared to other propulsion systems and must overcome a biased public fear due to hyper-environmentalism and a false perception of radiation and explosion risk.

  18. Stages of Ovarian Low Malignant Potential Tumors

    ... in the abdomen ) or in washings of the peritoneum ( tissue lining the peritoneal cavity). Stage II In ... in the abdomen ) or in washings of the peritoneum ( tissue lining the peritoneal cavity). Stage III Enlarge ...

  19. Stage at diagnosis and ovarian cancer survival

    Maringe, Camille; Walters, Sarah; Butler, John; Coleman, Michel P; Hacker, Neville; Hanna, Louise; Mosgaard, Berit J; Nordin, Andy; Rosen, Barry; Engholm, Gerda; Gjerstorff, Marianne L; Hatcher, Juanita; Johannesen, Tom B; McGahan, Colleen E; Meechan, David; Middleton, Richard; Tracey, Elizabeth; Turner, Donna; Richards, Michael A; Rachet, Bernard

    2012-01-01

    We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival.......We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival....

  20. Interconnected Levels of Multi-Stage Marketing

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...... in a multi-stage marketing context. This understanding assists managers in assessing and balancing different aspects of multi- stage marketing. The triadic perspective also offers avenues for further research.......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...

  1. Effect of kinetin on the course of cell cycle in successive developmental stages of the antheridial filaments of Chara vulgaris L.

    Mirosław Godlewski

    2014-02-01

    Full Text Available Effects of kinetin on the course of cell cycle in successive developmental stages of the antheridial filaments of Chara vulgaris L. were investigated. A shortening of the duration of cell cycles has been observed, particularly in initial. and final developmental stages. S phase. shortened in all stages whereas G2 phase+mitosis shortened in early but become longer in late developmental stages of filaments. Incorporation of 14C-adenine into cell nuclei increased after kinetin treatment in 4- and 8-celled filaments whereas that of 3H-phenylalanine increased in 8- and particularly 16-celled ones. This plant growth regulator stimulated also the 3H-thymidine incorporation into cells in studied developmental stages of filaments. The stimulation of radioactive phenylalanine incorporation into nucleus and cytoplasm was stronger in late G2 phase. A participation of cytokinins in the control of cell cycle in relation to process of differentiation of antheridial cells is discussed. A possibility of changes in the cytokinin content in antheridia and antheridial filament cells during their; development has been postulated.

  2. The New Lung Cancer Staging System

    Frank C. Detterbeck,MD, FCCP; Daniel J. Boffa, MD; Lynn T, Tanoue, MD, FCCP

    2009-01-01

    The International Association for the Study of Lung Cancer (IASLC) has conducted an extensive initiative to inform the revision of the lung cancer staging system. This involved development of an international database along with extensive analysis of a large population of patients and their prognoses. This article reviews the recommendations of the IASLC International Staging Committee for the definitions for the TNM descriptors and the stage grouping in the new non-small cell lung cancer staging system.

  3. The optimal multi-stage contest

    Fu, Qiang; Lu, Jingfeng

    2006-01-01

    This paper investigates the optimal (effort-maximizing) structure of multi-stage sequential-elimination contests with pooling competition in each stage. We allow the contest organizer to design the contest structure in two arms: contest sequence (the number of stages, and the number of remaining contestants in each stage), and prize allocation. First, we find that the optimality of "winner-take-all" (single final winner, single final prize, no intermediate prizes) is independent of the contes...

  4. Two-stage repair in hypospadias

    Haxhirexha, K. N.; Castagnetti, M; Rigamonti, W; Manzoni, G. A.

    2008-01-01

    We provide the reader with a nonsystematic review concerning the use of the two-stage approach in hypospadias repairs. A one-stage approach using the tubularized incised plate urethroplasty is a well-standardized approach for the most cases of hypospadias. Nevertheless, in some primary severe cases, in most hypospadias failures and in selected patients with balanitis xerotica obliterans a two-stage approach is preferable. During the first stage the penis is straightened, if necessary and the ...

  5. Modeling the three stages in HIV infection.

    Hernandez-Vargas, Esteban A.; Middleton, Richard H.

    2013-01-01

    A typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progress...

  6. A simplified staging system based on the radiological findings in different stages of ochronotic spondyloarthropathy

    Isaac Jebaraj; Binita Riya Chacko; George Koshy Chiramel; Thomas Matthai; Apurve Parameswaran

    2013-01-01

    This study describes a group of 26 patients with ochronotic spondyloarthropathy who were on regular treatment and follow-up at a tertiary level hospital and proposes a simplified staging system for ochronotic spondyloarthropathy based on radiographic findings seen in the thoracolumbar spine. This proposed classification makes it easy to identify the stage of the disease and start the appropriate management at an early stage. Four progressive stages are described: an inflammatory stage (stage ...

  7. Photoinduced phase transitions

    Nasu, K

    2004-01-01

    A new class of insulating solids was recently discovered. Whenirradiated by a few visible photons, these solids give rise to amacroscopic excited domain that has new structural and electronicorders quite different from the starting ground state. This occurrenceis called "photoinduced phase transition", and this multi-authoredbook reviews recent theoretical and experimental studies of this newphenomenon.

  8. Families in Transition .

    Bundy, Michael L., Ed.; Gumaer, James, Ed.

    1984-01-01

    Focuses on disrupted families and the role of the school counselor in helping children adjust. Describes characteristics of healthy families, and discusses the transition to the blended family, effects of divorce groups on children's classroom behavior, counseling children in stepfamilies, single-parent families, and parenting strengths of single…

  9. Variational transition state theory

    Truhlar, D.G. [Univ. of Minnesota, Minneapolis (United States)

    1993-12-01

    This research program involves the development of variational transition state theory (VTST) and semiclassical tunneling methods for the calculation of gas-phase reaction rates and selected applications. The applications are selected for their fundamental interest and/or their relevance to combustion.

  10. Citizens in sustainable transitions

    Hoffmann, Birgitte; Agger, Annika

    2013-01-01

    The paper explores how local public authorities can support and facilitate citizens’ participa-tion and learning in sustainable transition in urban neighbourhoods, by supporting local in-termediaries. The role of intermediaries can be performed by a variety of actors such as public housing associ...

  11. A Transiting Jupiter Analog

    Kipping, David M; Henze, Chris; Teachey, Alex; Isaacson, Howard T; Petigura, Erik A; Marcy, Geoffrey W; Buchhave, Lars A; Chen, Jingjing; Bryson, Steve T; Sandford, Emily

    2016-01-01

    Decadal-long radial velocity surveys have recently started to discover analogs to the most influential planet of our solar system, Jupiter. Detecting and characterizing these worlds is expected to shape our understanding of our uniqueness in the cosmos. Despite the great successes of recent transit surveys, Jupiter analogs represent a terra incognita, owing to the strong intrinsic bias of this method against long orbital periods. We here report on the first validated transiting Jupiter analog, Kepler-167e (KOI-490.02), discovered using Kepler archival photometry orbiting the K4-dwarf KIC-3239945. With a radius of $(0.91\\pm0.02)$ $R_{\\mathrm{Jup}}$, a low orbital eccentricity ($0.06_{-0.04}^{+0.10}$) and an equilibrium temperature of $(131\\pm3)$ K, Kepler-167e bears many of the basic hallmarks of Jupiter. Kepler-167e is accompanied by three Super-Earths on compact orbits, which we also validate, leaving a large cavity of transiting worlds around the habitable-zone. With two transits and continuous photometric ...

  12. Learning for Life Transitions

    Varmecky, Jane Hyde

    2012-01-01

    Many adults return to formal learning situations to pursue lifelong learning goals because their lives are in transition from dealing with real-life problems such as divorce and re-marriage. The purpose of this study was to describe what couples learned that contributed to the success of their subsequent marriages and how they learned it. The…

  13. Phase Transitions in QCD

    H. Satz(University of Bielefeld)

    2000-01-01

    At high temperatures or densities, hadronic matter shows different forms of critical behaviour: colour deconfinement, chiral symmetry restoration, and diquark condensation. I first discuss the conceptual basis of these phenomena and then consider the description of colour deconfinement in terms of symmetry breaking, through colour screening and as percolation transition.

  14. Stages of tuberculous meningitis: a clinicoradiologic analysis

    Objective: To determine the frequencies and percentages of various clinicoradiologic variables of tuberculosis meningitis (TBM) with reference to British Medical Research Council (BMRC) staging of the disease. Study Design: A case series. Place and Duration of Study: Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, from October 2010 to September 2011. Methodology: The study included 93 adult patients with the diagnosis of tuberculous meningitis (TBM) at the study place. Patients were divided in three groups according to British Medical Research Council (BMRC) staging of TBM. Different clinical and radiological findings were analyzed at different stages of the disease. Data was analyzed using SPSS (Statistical Package of Social Sciences) version 11.0. Results: A majority of patients were found to be in stage-II disease at the time of admission. History of illness at the time of admission was more than 2 weeks in 50% of stage-I patients but around 80% in stage-II and stage-III patients. Neck stiffness was the most commonly reported finding in all stages. Cranial nerve palsies were higher in stage-III (75%) than in stage-II (43%) and in stage-I (24%) patients. Hydrocephalus and basal enhancement was the most frequently reported radiographic abnormalities. Conclusion: Duration of illness and cranial nerve palsies are important variables in the diagnosis of TBM stages and if TBM is suspected, empiric treatment should be started immediately without bacteriologic proof to prevent morbidity and mortality. (author)

  15. CT perfusion at early stage of hepatic diffuse disease

    Sheng Guan; Wei-Dong Zhao; Kang-Rong Zhou; Wei-Jun Peng; Jian Mao; Feng Tang

    2005-01-01

    AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by dietthylnitrosamine in 14 rats of test group. Rats in control groupwere bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchymain different periods and pathologic changes in two groups were compared and analyzed.RESULTS: The process of hepatic diffuse lesions in test groups was dassified into three stages or periods according to the pathologic alterations, namely hepattitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF)of control group declined slightly, mean transit time (MTT),blood flow (BF) and volume (BV) increased, but there wereno significant differences between different periods. Tntest group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant.The ratio of BV and BF in test group to control group in stageof hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis.CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.

  16. Simulation studies of plasma waves in the electron foreshock - The transition from reactive to kinetic instability

    Dum, C. T.

    1990-06-01

    Particle simulation experiments were used to analyze the electron beam-plasma instability. It is shown that there is a transition from the reactive state of the electron beam-plasma instability to the kinetic instability of Langmuir waves. Quantitative tests, which include an evaluation of the dispersion relation for the evolving non-Maxwellian beam distribution, show that a quasi-linear theory describes the onset of this transition and applies again fully to the kinetic stage. This stage is practically identical to the late stage seen in simulations of plasma waves in the electron foreshock described by Dum (1990).

  17. Dimension changing phase transitions in instanton crystals

    We investigate lattices of instantons and the dimension-changing transitions between them. Our ultimate goal is the 3D→4D transition, which is holographically dual to the phase transition between the baryonic and the quarkyonic phases of cold nuclear matter. However, in this paper (just as in http://dx.doi.org/10.1007/JHEP11(2012)047) we focus on lower dimensions — the 1D lattice of instantons in a harmonic potential V∝M22x22+M32x22+M42x42, and the zigzag-shaped lattice as a first stage of the 1D→2D transition. We prove that in the low- and moderate-density regimes, interactions between the instantons are dominated by two-body forces. This drastically simplifies finding the ground state of the instantons’ orientations, so we made a numeric scan of the whole orientation space instead of assuming any particular ansatz. We find that depending on the M2/M3/M4 ratios, the ground state of instanton orientations can follow a wide variety of patterns. For the straight 1D lattices, we found orientations periodically running over elements of a ℤ2, Klein, prismatic, or dihedral subgroup of the SU(2)/ℤ2, as well as irrational but link-periodic patterns. For the zigzag-shaped lattices, we detected 4 distinct orientation phases — the anti-ferromagnet, another abelian phase, and two non-abelian phases. Allowing the zigzag amplitude to vary as a function of increasing compression force, we obtained the phase diagrams for the straight and zigzag-shaped lattices in the (force,M3/M4), (chemical potential,M3/M4), and (density,M3/M4) planes. Some of the transitions between these phases are second-order while others are first-order. Our techniques can be applied to other types of non-abelian crystals

  18. The Nuclear Cryogenic Propulsion Stage

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Belvin, Anthony D.; Borowski, Stanley K.; Scott, John H.

    2014-01-01

    Nuclear Thermal Propulsion (NTP) development efforts in the United States have demonstrated the technical viability and performance potential of NTP systems. For example, Project Rover (1955 - 1973) completed 22 high power rocket reactor tests. Peak performances included operating at an average hydrogen exhaust temperature of 2550 K and a peak fuel power density of 5200 MW/m3 (Pewee test), operating at a thrust of 930 kN (Phoebus-2A test), and operating for 62.7 minutes in a single burn (NRX-A6 test). Results from Project Rover indicated that an NTP system with a high thrust-to-weight ratio and a specific impulse greater than 900 s would be feasible. Excellent results were also obtained by the former Soviet Union. Although historical programs had promising results, many factors would affect the development of a 21st century nuclear thermal rocket (NTR). Test facilities built in the US during Project Rover no longer exist. However, advances in analytical techniques, the ability to utilize or adapt existing facilities and infrastructure, and the ability to develop a limited number of new test facilities may enable affordable development, qualification, and utilization of a Nuclear Cryogenic Propulsion Stage (NCPS). Bead-loaded graphite fuel was utilized throughout the Rover/NERVA program, and coated graphite composite fuel (tested in the Nuclear Furnace) and cermet fuel both show potential for even higher performance than that demonstrated in the Rover/NERVA engine tests.. NASA's NCPS project was initiated in October, 2011, with the goal of assessing the affordability and viability of an NCPS. FY 2014 activities are focused on fabrication and test (non-nuclear) of both coated graphite composite fuel elements and cermet fuel elements. Additional activities include developing a pre-conceptual design of the NCPS stage and evaluating affordable strategies for NCPS development, qualification, and utilization. NCPS stage designs are focused on supporting human Mars

  19. Numerical studies on laminar-turbulent transition in boundary layers

    Laminar-turbulent transition in flat-plate boundary layers is investigated by direct numerical solution of the full Navier-Stokes equations. Both forced transition (in parallel Blasius flow excited by a vibrating ribbon) and natural transition (in a decelerating boundary layer) are studied. In both cases, an initial state containing random noise is employed to eliminate bias in selecting unstable waves. In the simulations of ribbon-induced transition, close agreement with experiments (Saric et al. (1984)) is obtained for low-amplitude two-dimensional Tollmien-Schlichting waves-producing subharmonic breakdown (C- or H-type). For high amplitudes, a mixture of subharmonic and fundamental structures is observed. Clear-cut fundamental breakdown (K-type) is never obtained. In the simulation of the early stages of natural transition in a decelerating boundary layer, two-dimensional and/or slightly oblique waves initially grow due to the inflectional instability. When they become strong enough, they initiate a secondary instability leading to three dimensional distortion and Λ vortices, in good agreement with experiments (Gad-el-Hak et al. (1984)). The tips of the Λ vortices are rarely aligned with the flow direction, and that they appear locally in apace. A simple wave-interference model accounting for these features of natural transition has been developed. It suggests that multiple waves are active in the secondary instability, and that they are determined by unpredictable initial disturbances. The later stages of transition in a decelerating boundary layer were also studied with higher numerical resolution. The naturally-born Λ vortices undergo breakdown processes similar to those of ribbon-induced Λ vortices. Conversely, this justifies the conventional approach to study laminar-turbulent transition-the vibrating-ribbon technique

  20. Three stage semelparous Leslie models.

    Cushing, J M

    2009-07-01

    oscillations (not necessarily periodic) with separated life-cycle stages, while weak interactions promote stable equilibration with overlapping life-cycle stages. Methods used include the theory of planar monotone maps, average Lyapunov functions, and bifurcation theory techniques. PMID:18777023

  1. Optimum Staging with Varying Thrust Attitude Angle

    T. N. Srivastava

    1966-07-01

    Full Text Available Optimum staging programme for step rockets of arbitrary number of stages having different specific impulses and mass fractions with stages is derived, the optimization criterion being minimum take-off weight for a desired burntout velocity at an assigned altitude. Variation of thrust attitude angle from stage to stage and effects of gravity factor are taken into account. Analysis is performed for a degenerate problem obtained by relaxing the altitude constraint and it has been shown that problems of Weisbord, Subotowicz, Hall & Zambelli and Malina & Summerfield are the particular cases of the degenerate problem.

  2. The Mongolia experience: transitioning within transition.

    MacKenzie, Richard G

    2009-12-01

    Although Mongolia has a long and distinguished history, as a new and emerging democracy it is experiencing the pains of transition-one that is moving the country from its pastoral and nomadic past into the 21st century. Confounded by its previous dependence on socialist Soviet Russia, the concept of a market economy seems opportunistic for some, while for those living within the traditional lifestyle of the herdsman in the countryside it is confusing and threatening to family structure and values. Adolescents and young adults are caught at the interface-not only of their own development, but by the disparities between tradition and Western values, new technology, and freedoms granted by the emerging democracy, and by the civic practice of democracy itself. Conceptually the new belongs to the young, and yet limited health and educational resources are available to modulate and focus both threats and opportunities. Using the analogy of the spirit banner of the warrior, it is the young as the warriors of the 21st century who have the energy and investment in the future that will be needed to shepherd this change. Both personal and public health, within the context of development, the psychobiological model, and the political and social ecology will be strong determinants of success. It is a parallel investment in both youth and the ideals they represent that will ensure success for the new Mongolia. PMID:20653216

  3. Optimization of the method of stages through genetic algorithms for unavailable protection systems analysis considering aging effects

    When a safety system is under aging the failure times follow non-exponential distributions, and its interstate transition rates become time-dependent. It follows, therefore, that the stochastic process employed in the modeling becomes Nonmarkovian. In this thesis, this analysis is developed using an alternative method, called the device of stages which allows the transformation of Nonmarkovian models into equivalent Markovian ones. That transformation consists in reshaping the state transition diagram with time-dependent transition rates into a new one where fictitious states (called stages) are added and whose transition rates are constant. The number of added stages and their connections are identification parameters of the device of stages used for the equivalent Markovian model and requires a robust and efficient optimization tool. In order to perform a global search in such a topologically complex space, a genetic algorithm has been developed to automatically determine the stages combination and set of parameters which better represent the analyzed distribution. The developed genetic algorithm has demonstrated a good ability for optimizing the method of stages. Results concerning the application to a nuclear reactor protection system are shown and commented, in which the Weibull distribution is employed for modelling failure times. (author)

  4. Freedom and the Ibsen Stage

    Asbjφrn Aarseth

    2005-01-01

    To some extent Ibsen's career as a dramatist was conditioned by the physical limitations of the theatre buildings. He succeeded in turning these limitations to his advantage. Through dialogue and scenography he tried to achieve a longing in the audience to see the characters succeed in getting out of oppressive, prisonlike conditions. Gradually concentrating the action in the narrow room, he succeeded in achieving the effect of claustrophobia particularly in his work in the years 1877-86. After that he experimented in bringing the basic narrowness out in the open air scenography in 1888 with The Lady from the Sea. In Hedda Gabler and partly in John Gabriel Borkman he returned to the interior stage, but in the rest of the 1890s he preferred to situate some or most of the action in the open air. This selfimposed constriction is capable of producing an intense experience exactly because the urge to be free is amplified by the physical narrowness. Consequently it has proved difficult to make a successful movie on the basis of a modern prose play by Ibsen. The moving camera tends to dissolve the spatial limitations.

  5. Cross-stage immunity for malaria vaccine development

    Nahrendorf, Wiebke; Scholzen, Anja; Sauerwein, Robert W; Langhorne, Jean

    2015-01-01

    Highlights • Antigens are shared between liver and blood-stage malaria parasites. • Cross-stage antigens can mediate protection which is life cycle stage transcending. • Multi-stage malaria vaccine development should identify cross-stage antigens.

  6. Quantum theory of transition radiation and transition pair creation

    Baier, V. N.; Katkov, V. M.

    1998-01-01

    Theory of the transition radiation and the transition pair creation is developed in the frame of QED. The spectral-angular distributions of probability of the transition radiation and of the transition pair creation are found. The total energy losses of and the total probability of pair creation are calculated and analyzed. Features of radiation and pair creation processes in a superdence medium (typical for white dwarfs) are discussed.

  7. 75 FR 76921 - Tobacco Transition Payment Program; Tobacco Transition Assessments

    2010-12-10

    ... Corporation 7 CFR Part 1463 RIN 0560-AH30 Tobacco Transition Payment Program; Tobacco Transition Assessments... Commodity Credit Corporation (CCC) is modifying the regulations for the Tobacco Transition Payment Program (TTPP) to clarify, consistent with current practice and as required by the Fair and Equitable...

  8. Effect of point defects and disorder on structural phase transitions

    Toulouse, J.

    1997-06-01

    Since the beginning in 1986, the object of this project has been Structural Phase Transitions (SPT) in real as opposed to ideal materials. The first stage of the study has been centered around the role of Point Defects in SPT`s. Our intent was to use the previous knowledge we had acquired in the study of point defects in non-transforming insulators and apply it to the study of point defects in insulators undergoing phase transitions. In non-transforming insulators, point defects, in low concentrations, marginally affect the bulk properties of the host. It is nevertheless possible by resonance or relaxation methods to study the point defects themselves via their local motion. In transforming solids, however, close to a phase transition, atomic motions become correlated over very large distances; there, even point defects far removed from one another can undergo correlated motions which may strongly affect the transition behavior of the host. Near a structural transition, the elastic properties win be most strongly affected so as to either raise or decrease the transition temperature, prevent the transition from taking place altogether, or simply modify its nature and the microstructure or domain structure of the resulting phase. One of the well known practical examples is calcium-stabilized zirconia in which the high temperature cubic phase is stabilized at room temperature with greatly improved mechanical properties.

  9. Emergence and Phase Transitions

    Sikkema, Arnold

    2006-05-01

    Phase transitions are well defined in physics through concepts such as spontaneous symmetry breaking, order parameter, entropy, and critical exponents. But emergence --- also exhibiting whole-part relations (such as top-down influence), unpredictability, and insensitivity to microscopic detail --- is a loosely-defined concept being used in many disciplines, particularly in psychology, biology, philosophy, as well as in physics[1,2]. I will review the concepts of emergence as used in the various fields and consider the extent to which the methods of phase transitions can clarify the usefulness of the concept of emergence both within the discipline of physics and beyond.1. Robert B. Laughlin, A Different Universe: Reinventing Physics from the Bottom Down (New York: Basic Books, 2005). 2. George F.R. Ellis, ``Physics and the Real World'', Physics Today, vol. 58, no. 7 (July 2005) pp. 49-54.

  10. Transition Radiation Detectors

    Andronic, A

    2012-01-01

    We review the basic features of transition radiation and how they are used for the design of modern Transition Radiation Detectors (TRD). The discussion will include the various realizations of radiators as well as a discussion of the detection media and aspects of detector construction. With regard to particle identification we assess the different methods for efficient discrimination of different particles and outline the methods for the quantification of this property. Since a number of comprehensive reviews already exist, we predominantly focus on the detectors currently operated at the LHC. To a lesser extent we also cover some other TRDs, which are planned or are currently being operated in balloon or space-borne astro-particle physics experiments.

  11. Map Projection Transitions

    Nedjeljko Frančula

    2013-06-01

    Full Text Available Map Projection Transitions is a very successful web application about map projections. The web page (http://www.jasondavies.com/maps/transition pre­sents a world map with graticule and country borders in the oblique Aitoff projection, with the South Pole. The map is not static, but animated. The South Pole moves toward the bottom and Earth rotates around its poles. The animation lasts five seconds, after which the projection changes and movement continues for five seconds, after which the projection changes again. Names of projections appear in a separate window. There are a total of 56 projections. The South Pole eventually becomes invisible and the North Pole appears at the top. Various parts of Earth appear in the center of the map by rotating around the poles.

  12. Online Community Transition Detection

    Tan, Biying; Zhu, Feida; Qu, Qiang;

    2014-01-01

    Mining user behavior patterns in social networks is of great importance in user behavior analysis, targeted marketing, churn prediction and other applications. However, less effort has been made to study the evolution of user behavior in social communities. In particular, users join and leave...... communities over time. How to automatically detect the online community transitions of individual users is a research problem of immense practical value yet with great technical challenges. In this paper, we propose an algorithm based on the Minimum Description Length (MDL) principle to trace the evolution of...... community transition of individual users, adaptive to the noisy behavior. Experiments on real data sets demonstrate the efficiency and effectiveness of our proposed method....

  13. Transition to Clean Technology

    Acemoglu, Daron; Akcigit, Ufuk; Hanley, Douglas; Kerr,William Robert

    2014-01-01

    We develop a microeconomic model of endogenous growth where clean and dirty technologies compete in production and innovation-in the sense that research can be directed to either clean or dirty technologies. If dirty technologies are more advanced to start with, the potential transition to clean technology can be difficult both because clean research must climb several steps to catch up with dirty technology and because this gap discourages research effort directed towards clean technologies....

  14. Transitional justice and aid

    Hellsten, Sirkku K.

    2012-01-01

    This paper examines the current security-governance-development nexus, something that is often also discussed under the concept of transitional justice (TJ). The paper analyses how the ambiguous, evolving and expanding nature of the concept of TJ affects the planning, coordination, evaluation and assessment of aid given to conflict ridden, post-conflict or (post) authoritarian societies in order to strengthen their democracy. Special attention is paid to gender justice. Illustrations are draw...

  15. Transition feeding of sows

    Theil, Peter Kappel

    to shifts in housing, and in Europe, this shift is now associated with a change from loose group housing to individual housing. Around parturition, colostrum is being secreted and milk synthesis is initiated in the mammary glands. After the onset of lactation, milk composition changes, especially...... feeding practices do not acknowledge these changes. Development of new feeding strategies specifically adapted for the transition sow is likely of importance to match the rapid changes in nutrient requirements....

  16. ATLAS Transitional Radiation Tracker

    ATLAS Outreach

    2006-01-01

    This colorful 3D animation is an excerpt from the film "ATLAS-Episode II, The Particles Strike Back." Shot with a bug's eye view of the inside of the detector. The viewer is taken on a tour of the inner workings of the transitional radiation tracker within the ATLAS detector. Subjects covered include what the tracker is used to measure, its structure, what happens when particles pass through the tracker, how it distinguishes between different types of particles within it.

  17. Monte Carlo transition probabilities

    Lucy, L. B.

    2001-01-01

    Transition probabilities governing the interaction of energy packets and matter are derived that allow Monte Carlo NLTE transfer codes to be constructed without simplifying the treatment of line formation. These probabilities are such that the Monte Carlo calculation asymptotically recovers the local emissivity of a gas in statistical equilibrium. Numerical experiments with one-point statistical equilibrium problems for Fe II and Hydrogen confirm this asymptotic behaviour. In addition, the re...

  18. Women in Transition

    UNICEF Innocenti Research Centre. MONEE project

    1999-01-01

    The 1999 Central and Eastern Europe and Commonwealth of Independent States Regional Monitoring Report focuses on the experiences of girls and women during the transition, highlighting their role in regional progress and the obstacles they face. The Report covers a broad range of issues, including women’s participation in the emerging market economy and democratic governments, female access to health and education, trends in family formation and violence against women and girls. The Report cal...

  19. Stimulated coherent transition radiation

    Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed

  20. Seasonal smooth transition autoregression

    Franses, Philip Hans; Bruin, Paul; Dijk, Dick van

    2000-01-01

    textabstractIn this paper we put forward a new time series model, which describes nonlinearity and seasonality simultaneously. We discuss its representation, estimation of the parameters and inference. This seasonal STAR (SEASTAR) model is examined for its practical usefulness by applying it to 18 quarterly industrial production series. The data are tested for smooth-transition nonlinearity and for time-varying seasonality. We find that the model fits the data well for 14 of the 18 series. We...

  1. IPCC encourages energy transition

    Dryness, floods, food insecurity, population migrations, conflicts are some of the risks that climate change would pose. These risks are listed in the second volume ('Impacts, Adaptation, and Vulnerability') of the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) published on March 31, 2014. The proposed mitigation measures are presented in a third volume published on April 13, in which the IPCC proposes to accelerate the energy transition. This short paper summarizes the conclusions of the Fifth Assessment Report

  2. A Continent in Transition

    2011-01-01

    AFRICA has survived a year of great change.Most notable has been the transition affecting North Africa,where waves of protests resulted in regime changes in Libya,Tunisia,and Egypt.When the dust had settled,Libya's former leader Muammar Gaddafi lay dead in a storm water drain and Egypt's former leader Hosni Mubarrak lay frail and fearful on a bed in a courtroom,on trial for his life.

  3. Planning rapid transit networks

    G Laporte; Mesa, J. A.; Ortega, F.A.; Perea Rojas Marcos, Federico

    2011-01-01

    Rapid transit construction projects are major endeavours that require long-term planning by several players, including politicians, urban planners, engineers, management consultants, and citizen groups. Traditionally, operations research methods have not played a major role at the planning level but several tools developed in recent years can assist the decision process and help produce tentative network designs that can be submitted to the planners for further evaluation. This article review...

  4. TRANSITION AND AGRICULTURE

    Rozelle, Scott D.; Swinnen, Johan F.M.

    2000-01-01

    The overall objectives of our proposed paper is to: (a) systematically document the post-reform trends in agricultural performance in Asia, Europe, and the Former Soviet Union; (b) identify the main reform strategies and institutional innovations that have contributed to the successes and failures of the sector; (c) analyze the mechanisms by which reform policies and initial conditions have affected the transition process in agriculture; and (d) draw lessons and policy implications from the e...

  5. Embolus in transit.

    Dejecacion, Jodie; Veselka, Deanne; Ragain, Michael; Jenkins, Leigh Ann; Meyerrose, Gary

    2003-11-01

    A patient who presented with recurrent syncopal episodes was discovered to have a right-sided heart mass, which was revealed as an embolus in transit resulting in a lethal pulmonary embolic event. The initial focus of etiology on tumor rather than thrombus was misleading. A higher index of suspicion of thrombus in right heart mass may help future patients receive more directed therapy. PMID:14632370

  6. Ionization by nuclear transitions

    A phenomenological description of ionization events is given that applies to both shaking transitions of the composite nucleus-atom system and the process in which the charged particles emitted in a nuclear decay transfer energy by a relatively slow ''direct collision'' final state interaction with atomic electrons. Specific areas covered include shakeoff in internal conversion, shakeoff in electron capture, shakeoff in beta decay, and inner electron ejection in alpha decay. (5 figs., 1 table)

  7. The US Demographic Transition

    Jeremy Greenwood; Ananth Seshadri

    2002-01-01

    Between 1800 and 1940 the U.S. went through a dramatic demographic transition. In 1800 the average woman had 7 children, and 94 percent of the population lived in rural areas. By 1940 the average woman birthed just 2 kids, and only 43 percent of populace lived in the country. The question is: What accounted for this shift in the demographic landscape? The answer given here is that technological progress in agriculture and manufacturing explains these facts.

  8. 14 CFR 91.859 - Modification to meet Stage 3 or Stage 4 noise levels.

    2010-01-01

    ... noise levels. 91.859 Section 91.859 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Noise Limits § 91.859 Modification to meet Stage 3 or Stage 4 noise levels. For an airplane subject to... Stage 3 or Stage 4 noise levels....

  9. Anomalous radiative transitions

    Anomalous transitions involving photons derived by many-body interaction of the form ∂μGμ in the standard model are studied for the first time. This does not affect the equation of motion in the bulk, but modifies the wavefunctions, and causes an unusual transition characterized by a time-independent probability. In the transition probability at a time interval T expressed generally in the form P=TΓ0+P(d), now with P(d)≠0. The diffractive term P(d) has its origin in the overlap of waves of the initial and final states, and reveals the characteristics of waves. In particular, the processes of the neutrino–photon interaction ordinarily forbidden by the Landau–Yang theorem (Γ0=0) manifest themselves through the boundary interaction. The new term leads physical processes over a wide energy range to have finite probabilities. New methods of detecting neutrinos using lasers are proposed, based on this diffractive term; these would enhance the detectability of neutrinos by many orders of magnitude

  10. Economic Growth Models Transition

    Coralia Angelescu

    2006-03-01

    Full Text Available The transitional recession in countries of Eastern Europe has been much longer than expected. The legacy and recent policy mistakes have both contributed to the slow progress. As structural reforms and gradual institution building have taken hold, the post-socialist economics have started to recover, with some leading countries building momentum toward faster growth. There is a possibility that in wider context of globalization several of these emerging market economies will be able to catch up with the more advanced industrial economies in a matter of one or two generations. Over the past few years, most candidate countries have made progress in the transition to a competitive market economy, macroeconomic stabilization and structural reform. However their income levels have remained far below those in the Member States. Measured by per capita income in purchasing power standards, there has been a very limited amount of catching up over the past fourteen years. Prior, the distinctions between Solow-Swan model and endogenous growth model. The interdependence between transition and integration are stated in this study. Finally, some measures of macroeconomic policy for sustainable growth are proposed in correlation with real macroeconomic situation of the Romanian economy. Our study would be considered the real convergence for the Romanian economy and the recommendations for the adequate policies to achieve a fast real convergence and sustainable growth.

  11. Transition and modernization

    Krištofić Branimir

    2002-01-01

    Full Text Available The fall of the communist orders introduced a problem of the development of these societies and initiated a new wave of modernization theories. At the same time, the ideological proclamation of the victory of neo-liberalism resulted in the inauguration of the neo-liberal development model as the mode of modernization that will include the post-communist countries in the process of globalization. In this context, the World Bank study of the ten-year development of the transitional countries has been analyzed. With the example of Slovenia, as the economically most successful transitional country, it is shown that the study encounters the problem of constructing a general model of the development, which could be applied to all transitional countries. Additionally, it is shown that the World Bank model, as well as classic modernization theories, cannot predict how certain country will react to economic reform. Therefore, an issue of reform support arises as a significant one. Controversy of the neo-liberal modernization model indicates a need for articulating alternative modes of development.

  12. Economic Growth Models Transition

    Coralia Angelescu

    2006-01-01

    Full Text Available The transitional recession in countries of Eastern Europe has been much longer than expected. The legacy and recent policy mistakes have both contributed to the slow progress. As structural reforms and gradual institution building have taken hold, the post-socialist economics have started to recover, with some leading countries building momentum toward faster growth. There is a possibility that in wider context of globalization several of these emerging market economies will be able to catch up with the more advanced industrial economies in a matter of one or two generations. Over the past few years, most candidate countries have made progress in the transition to a competitive market economy, macroeconomic stabilization and structural reform. However their income levels have remained far below those in the Member States. Measured by per capita income in purchasing power standards, there has been a very limited amount of catching up over the past fourteen years. Prior, the distinctions between Solow-Swan model and endogenous growth model. The interdependence between transition and integration are stated in this study. Finally, some measures of macroeconomic policy for sustainable growth are proposed in correlation with real macroeconomic situation of the Romanian economy. Our study would be considered the real convergence for the Romanian economy and the recommendations for the adequate policies to achieve a fast real convergence and sustainable growth.

  13. The energy transition

    In a first part, the author proposes an analysis of energy transition and of its consequences on the competitive environment. He recalls the main characteristics of energy transition and more particularly focuses on two aspects: the development of renewable energies and the management of demand. Thus, the author discusses the following issues: the relationship between the struggle against climate change and the low carbon economy, the development of renewable energies, the evolution and main actors of photovoltaic array and of wind turbine production, the distribution of photovoltaic and wind energy installed production among countries, and some key figures about the main renewable energy operators in Europe. He discusses how to manage consumptions, and operations performed. In a second part, the author addresses the impact of the German energy transition (Energiewende) on the business models of the main German energy operators (RWE and E.On). He recalls and comments the objective of this energy policy, presents the German electric and gas sector, comments the evolution of the electric utilities since 1998, more presently presents and discusses the activities of RWE and E.On, the evolution of their main financial indicators, and the levels of installed power with respect of energy sources

  14. Public Transit Use Among Immigrants

    Heisz, Andrew; Schellenberg, Grant

    2004-01-01

    This paper examines the likelihood of immigrants and the Canadian-born to use public transit. It also discusses implications for public transit services. It uses data from the 1996 and 2001 censuses of Canada.

  15. Entanglement and quantum phase transitions

    Gu, Shi-Jian; Tian, Guang-Shan; Lin, Hai-Qing

    2005-01-01

    We examine several well known quantum spin models and categorize behavior of pairwise entanglement at quantum phase transitions. A unified picture on the connection between the entanglement and quantum phase transition is given.

  16. Acting Antarctica: science on stage

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia

    2016-04-01

    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  17. Classification, staging and prognosis of lung cancer

    Lung cancer has increased in incidence throughout the twentieth century and is now the most common cancer in the Western World. It has a poor prognosis, only 10-15% of patients survive 5 years or longer. Outcome is dependent on clinical stage and cancer cell type. Lung cancer is broadly subclassified on the basis of histological features into squamous cell carcinoma, adenocarcinoma, large cell carcinoma and small cell carcinoma. The histopathological type of lung cancer correlates with tumour behaviour and prognosis. Staging based on prognosis is essential in clinical trials comparing different management strategies, and enables universal communication regarding the efficacy of different treatments in specific patient groups. The anatomic extent of disease determined either preoperatively using imaging supplemented by invasive procedures such as mediastinoscopy, and anterior mediastinotomy or following resection are described according to the T-primary tumour, N-regional lymph nodes, M-distant metastasis classification. The International System for Staging Lung Cancer attempts to group together patients with similar prognosis and treatment options. Various combinations of T, N, and M define different clinical or surgical-pathological stages (IA-IV) characterised by different survival characteristics. Refinements in staging based on imaging findings have enabled clinical staging to more accurately reflect the surgical-pathological stage and therefore more accurately predict prognosis. Recent advances including the use of positron emission tomography in combination with conventional staging promises to increase the accuracy of staging and therefore to reduce the number of invasive staging procedures and inappropriate thoracotomies

  18. Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

    2016-06-20

    Stage II Contiguous Adult Diffuse Large Cell Lymphoma; Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma

  19. Partnership Transitions and Maternal Parenting

    Beck, Audrey N.; Cooper, Carey E.; McLanahan, Sara; Brooks-Gunn, Jeanne

    2010-01-01

    We use data from the Fragile Families and Child Wellbeing Study (N = 1,975) to examine the association between mothers’ partnership changes and parenting behavior during the first five years of their children’s lives. We compare coresidential with dating transitions, and recent with more distal transitions. We also examine interactions between transitions and race/ethnicity, maternal education and family structure at birth. Findings indicate that both coresidential and dating transitions were...

  20. Dynamic Phase Transitions in Superconductivity

    Ma, Tian; Wang, Shouhong

    2007-01-01

    In this Letter, the dynamic phase transitions of the time-dependent Ginzburg-Landau equations are analyzed using a newly developed dynamic transition theory and a new classification scheme of dynamics phase transitions. First, we demonstrate that there are two type of dynamic transitions, jump and continuous, dictated by the sign of a nondimensional parameter R. This parameter is computable, and depends on the material property, the applied field, and the geometry of domain that the sample oc...

  1. Precision photometry for planetary transits

    Pont, F; Pont, Frederic; Moutou, Claire

    2007-01-01

    We review the state of the art in follow-up photometry for planetary transit searches. Three topics are discussed: (1) Photometric monitoring of planets discovered by radial velocity to detect possible transits (2) Follow-up photometry of candidates from photometric transit searches to weed out eclipsing binaries and false positives (3) High-precision lightcurves of known transiting planets to increase the accuracy on the planet parameters.

  2. X-ray transitions in Br XXIV-XXVIII

    Transitions in the wavelength region 4.9-8.1 A from Br , , , , and have been identified in spectra from laser-produced plasmas. The identifications were made using ab initio calculations of wavelengths and oscillator strengths. Spatially resolved spectra were recorded for laser irradiation intensities from 3 x 10/sup 13/ to 4 x 10/sup 14/ W/cm2. The dependence of the spectral lines on the distance from the target and on the irradiation intensity was very useful in distinguishing the transitions from different ionization stages

  3. One-Stage and Bayesian Two-Stage Optimal Designs for Mixture Models

    Lin, Hefang

    1999-01-01

    In this research, Bayesian two-stage D-D optimal designs for mixture experiments with or without process variables under model uncertainty are developed. A Bayesian optimality criterion is used in the first stage to minimize the determinant of the posterior variances of the parameters. The second stage design is then generated according to an optimality procedure that collaborates with the improved model from first stage data. Our results show that the Bayesian two-stage D-D optimal design...

  4. Boundary Layer Transition on an Axial Compressor Stator Blade-Wake Passing and Freestream Turbulence Effects

    Walker, G. J.; Solomon, W. J.

    2007-01-01

    Quantitative observations of transitional boundary layers in regions of strong flow deceleration on an axial compressor stator blade are reported. Measurements are obtained at a fixed chordwise position, and the blade incidence was varied by changing the compressor throughflow so as to move the transition region relative to the stationary probe. It was thus possible to observe typical boundary layer behavior at various stages of transition in the turbomachine environment. The range of observations covers separating laminar flow at transition onset, and reattachment of intermittently turbulent periodically separated shear layers.

  5. Risk Assessment on the Transition Program for Air Traffic Control Automation System Upgrade

    Li Dong Bin

    2016-01-01

    Full Text Available We analyzed the safety risks of the transition program for Air Traffic Control (ATC automation system upgrade by using the event tree analysis method in this paper. We decomposed the occurrence progress of the three transition phase and built the event trees corresponding to the three stages, and then we determined the probability of success of each factor and calculated probability of success of the air traffic control automation system upgrade transition. In the conclusion, we illustrate the transition program safety risk according to the results.

  6. Pantex staging study near-term alternatives

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components' final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  7. Pantex staging study near-term alternatives

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components` final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  8. Staging of laser-plasma accelerators

    Steinke, S.; van Tilborg, J.; Benedetti, C.; Geddes, C. G. R.; Daniels, J.; Swanson, K. K.; Gonsalves, A. J.; Nakamura, K.; Shaw, B. H.; Schroeder, C. B.; Esarey, E.; Leemans, W. P.

    2016-05-01

    We present results of an experiment where two laser-plasma-accelerator stages are coupled at a short distance by a plasma mirror. Stable electron beams from the first stage were used to longitudinally probe the dark-current-free, quasi-linear wakefield excited by the laser of the second stage. Changing the arrival time of the electron beam with respect to the second stage laser pulse allowed reconstruction of the temporal wakefield structure, determination of the plasma density, and inference of the length of the electron beam. The first stage electron beam could be focused by an active plasma lens to a spot size smaller than the transverse wake size at the entrance of the second stage. This permitted electron beam trapping, verified by a 100 MeV energy gain.

  9. Alameda-Contra Costa Transit District (AC Transit) Fuel Cell Transit Buses: Preliminary Evaluation Results

    Chandler, K.; Eudy, L.

    2007-03-01

    This report provides an evaluation of three prototype fuel cell-powered transit buses operating at AC Transit in Oakland, California, and six baseline diesel buses similar in design to the fuel cell buses.

  10. Computerized System for Staging Peritoneal Surface Malignancies

    Sammartino, Paolo; Biacchi, Daniele; Cornali, Tommaso; Accarpio, Fabio; Sibio, Simone; Luraschi, Bernard; Impagnatiello, Alessio; Di Giorgio, Angelo

    2015-01-01

    Background Peritoneal surface malignancies (PSMs) are usually staged using Sugarbaker’s Peritoneal Cancer Index (PCI) and completeness of cytoreduction score (CC-s). Although these staging tools are essential for selecting patients and evaluating outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), both scoring models lack some anatomic information, thus making staging laborious and unreliable. Maintaining Sugarbaker’s original concepts, we therefo...

  11. The staging and classification of cancers

    The primary theme of this chapter is to place in perspective the process and purpose of tumor staging for both the oncologist and the radiologist. The foundation used for this discussion will be the Manual for Staging of Cancer-1983, published by the American Joint Committee for Cancer. Because the specifics of staging and classification by body site will be the province of the chapters that follow, only a broad discussion of the principles and applications of this system is given

  12. Numerical simulation of radial compressor stage

    Luňáček O.; Syka T.

    2013-01-01

    Article describes numerical simulations of air flow in radial compressor stage in NUMECA CFD software. In simulations geometry variants with and without seals are used. During tasks evaluating was observed seals influence on flow field and performance parameters of compressor stage. Also is described CFDresults comparison with results from design software based on experimental measurements and monitoring of influence of seals construction on compressor stage efficiency.

  13. Burkitt Lymphoma: Staging and Response Evaluation

    Sandlund, John T.

    2012-01-01

    The refinements in both the staging and response evaluation of children with Burkitt lymphoma (BL) have contributed to the improvements in treatment outcome observed over the past 40 years. Ziegler and Magrath designed a staging system in the 1970s for children with BL in equatorial Africa. Currently, the most widely used staging system around the world is that described by Murphy in 1980, which was developed for children with non-Hodgkin lymphoma (NHL) of any histology. There are opportuniti...

  14. Designing for Different Stages in Behavior Change

    Karapanos, Evangelos

    2016-01-01

    The behavior change process is a dynamic journey with different informational and motivational needs across its different stages; yet current technologies for behavior change are static. In our recent deployment of Habito, an activity tracking mobile app, we found individuals "readiness" to behavior change (or the stage of behavior change they were in) to be a strong predictor of adoption. Individuals in the contemplation and preparation stages had an adoption rate of 56%, whereas individuals...

  15. Staging lung cancer: role of endobronchial ultrasound

    Inage T; Nakajima T; Yoshino I

    2014-01-01

    Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinoscopy is k...

  16. Staging lung cancer: role of endobronchial ultrasound

    Nakajima, Takahiro

    2014-01-01

    Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinosc...

  17. Lung Cancer Staging: Clinical and Radiologic Perspectives

    Chheang, Sophie; Brown, Kathleen

    2013-01-01

    Published in 2009, the 7th edition of the American Joint Committee on Cancer TNM staging system is the culmination of an extensive worldwide initiative to standardize and validate lung cancer staging. Unlike prior editions, the new staging system is now inclusive of small cell carcinoma and carcinoid tumors. In addition, significant changes were made to the T and M descriptors, resulting in improved prognostic stratification of disease. This review article highlights these changes, the ration...

  18. Saturn IBC S-IVB Stage

    1967-01-01

    Workmen secure a J-2 engine onto the S-IVB (second) stage thrust structure. As part of Marshall Space Center's 'building block' approach to the Saturn development, the S-IVB was utilized in the Saturn IBC launch vehicle as a second stage and the Saturn V launch vehicle as a third stage. The booster, built for NASA by McDornell Douglas Corporation, was powered by a single J-2 engine, initially capable of 200,000 pounds of thrust.

  19. Protected transitional solution to transformational satellite communications

    Brand, Jerry C.

    2005-06-01

    As the Warfighter progresses into the next generation battlefield, transformational communications become evident as an enabling technology. Satellite communications become even more vital as the battles range over greater non-contiguous spaces. While current satellite communications provide suitable beyond line-of-sight communications and the Transformational Communications Architecture (TCA) sets the stage for sound information exchange, a realizable transition must occur to ensure successful succession to this higher level. This paper addresses the need for a planned escalation to the next generation satellite communications architecture and offers near-term alternatives. Commercial satellite systems continue to enable the Warfighter to reach back to needed information resources, providing a large majority of available bandwidth. Four areas of concentration for transition include encrypted Telemetry, Tracking and Control (or Command) (TT&C), encrypted and covered data, satellite attack detection and protection, and operational mobility. Solution methodologies include directly embedding COMSEC devices in the satellites and terminals, and supplementing existing terminals with suitable equipment and software. Future satellites planned for near-term launches can be adapted to include commercial grade and higher-level secure equipment. Alternately, the expected use of programmable modems (Software Defined Radios (SDR)) enables incorporation of powerful cipher methods approaching military standards as well as waveforms suitable for on-the-move operation. Minimal equipment and software additions on the satellites can provide reasonable attack detection and protection methods in concert with the planned satellite usage. Network management suite modifications enable cohesive incorporation of these protection schemes. Such transitional ideas offer a smooth and planned transition as the TCA takes life.

  20. Electromagnetic transition operators, ch. 9

    Some of the basic equations related to the electromagnetic interaction are summarized. A derivation of the operators that are used to calculate electromagnetic transitions and moments is given. Centre-of-mass corrections are treated. The angular-momentum and parity selection rules are discussed. Measurable quantities such as reduced transition rates, lifetimes, branching and mixing ratios are defined. The much-used Weisskopf single-particle estimates of transition strengths are derived. It is shown that the isospin formalism allows to express transition strengths in terms of isoscalar and isovector contributions. This separation can be used for example, to correlate transition rates in isobaric mass multiplets

  1. Induction Charge Detector with Multiple Sensing Stages

    Gamero-Castano, Manuel

    2008-01-01

    An induction charge detector with multiple sensing stages has been conceived for use in characterizing sprayed droplets, dust particles, large ionized molecules, and the like. Like related prior single-stage devices, each stage yields a measurement of the electric charge and the time of flight of the particle. In effect, an n-stage sensor yields n independent sets of such measurements from the same particle. The benefit of doing this is to increase the effective signal-to-noise ratio and thereby lower the charge-detection limit and the standard error of the charge measurement.

  2. Evolution in Stage-Structured Populations

    Barfield, Michael; Holt, Robert D.; Gomulkiewicz, Richard

    2016-01-01

    For many organisms, stage is a better predictor of demographic rates than age. Yet no general theoretical framework exists for understanding or predicting evolution in stage-structured populations. Here, we provide a general modeling approach that can be used to predict evolution and demography of stage-structured populations. This advances our ability to understand evolution in stage-structured populations to a level previously available only for populations structured by age. We use this framework to provide the first rigorous proof that Lande’s theorem, which relates adaptive evolution to population growth, applies to stage-classified populations, assuming only normality and that evolution is slow relative to population dynamics. We extend this theorem to allow for different means or variances among stages. Our next major result is the formulation of Price’s theorem, a fundamental law of evolution, for stage-structured populations. In addition, we use data from Trillium grandiflorum to demonstrate how our models can be applied to a real-world population and thereby show their practical potential to generate accurate projections of evolutionary and population dynamics. Finally, we use our framework to compare rates of evolution in age- versus stage-structured populations, which shows how our methods can yield biological insights about evolution in stage-structured populations. PMID:21460563

  3. ERK AND RSK SEQUENTIALLY REGULATE DISTINCT STAGES OF EPITHELIAL-MESENCHYMAL TRANSITION

    Čáslavský, Josef; Klímová, Zuzana; Vomastek, Tomáš

    2012-01-01

    Roč. 1, October 2012 (2012), s. 20-20. ISSN 2235-4956. [The Batsheva de Rothschild Seminar on Biochemistry, Biology and Pathology of MAP Kinases. 14.10.2012-18.10.2012, Jerusalem Hills] R&D Projects: GA ČR GA204/09/0614 Institutional support: RVO:61388971 Keywords : ERK * RSK

  4. BN-800 reactor is a new stage in transition to innovative nuclear power

    Poplavsky, V.M.; Chebeskov, A.N.; Matveev, V.I. [State Scientific Center of the Russian Federation, Institute for Physics and Power Engineering named after A.I. Leypunsky, Obninsk Kaluga region (Russian Federation)

    2007-07-01

    This paper presents the perspectives of nuclear power development in Russia and the reasons why it is necessary to use for that fast reactor technology. Some features of fast reactor technology and main ideas and technical approaches that have been used in the design of the BN-800 sodium cooled fast reactor are given as well. The BN-800 design is based on the BN-600 design with a series of innovative modifications: -) changing the size and structure of the upper axial blanket in order to get a zero or negative sodium void reactivity effect, -) the addition of scram rods based on passive activation, -) the addition of passive system of emergency cooling with sodium-air heat exchangers, -) a special in-vessel catcher envisaged under the core to catch and retain fragments of the core in case of core disruptive accident, and -) an improved earthquake resistance of all the structures. Such issues as possible options of fuel cycle, closing fuel cycle, transuranium element burning, disposal of plutonium being withdrawn from military programs, etc. are discussed as applied to the BN-800 reactor. Some economic considerations in general outline of the BN-800 unit are presented in the paper. It is important to note that the commissioning of the BN-800 reactor was included into the Federal Goal-Oriented Program - Development of nuclear energy-industrial complex of Russia for 2007-2010 and for perspective up to 2015 -, which was approved by the Russian Government in October 2006.

  5. Multilevel rotational transitions at intermediate stage of three-phonon molecular ionization

    Processes of two-atom molecules ionization under effect of weak field and intensive linearity polarized mono chronic radiation are studied. It is shown that the field mixing of rotational components of various electron-oscillatory molecular states by the field intensity may lead to the populations density migration by angular moment therefore ions with rotational moments may be formed from non excited molecules in the process of three-photon ionization

  6. Stage-by-Stage Certification of Trees in Plantations of Scots Pine Genetic Breeding Complex

    V. V. Tarakanov

    2014-08-01

    Full Text Available In Altai territory in Scots pine (Pinus sylvestris L. clonal plantations, that include nearly 1.5 thousand trees of 118 clones, the stage-by-stage certification of trees was carried out. Certification process included 3 stages: 1 forestry stage (preliminary, 2 phenetic stage (basic, 3 genetical stage (précising. Accuracy of phenetic certification was 97.1 %. The final stage of certification was carried out taking into account of revealed «phenetic clusters» within of clones. One-ramet and many-ramets («mixed» samples were compared within clusters and these must show identical results if all ramets are truly marked. The stage-by-stage certification method allows less expensive molecular genetics testing in some cases.

  7. Lost in Transit

    Lange, Ida Sofie Gøtzsche; Laursen, Lea Louise Holst; Lassen, Claus;

    of contact (Jensen & Morelli 2011) between four influential layers: History, Flow, Materiality and Meaning. The analysis shows an unbalance between the layers which negatively influence the functionality and experience of the place. Through an empirical and ethnography exploration this paper seeks to expose...... how a town primarily characterized by ferry transit is being challenged on its capacity to be a 'place' of meaning and social importance to its inhabitants. The paper raises the key question: Can a place become too well connected and this in such a manner that its identity and key character becomes...

  8. Transitions -- Design a Courthouse

    Xu, Jun

    1999-01-01

    The project is a courthouse designed in the town of Blacksburg. It will not only provides an important and functional public building in the local architectural history, but also improves the urban situation and zoning separation of the town. The corner condition of the project is the focus point of the design, with the architectural interpretation of transition of the scale, material, and the path. The hierarchy of the civic spirit is considered in the façade as well as in the courtrooms...

  9. Place in Transition

    Mikkelsen, Jacob Bjerre; Lange, Ida Sofie Gøtzsche

    redefinition of oil rigs from an urban design perspective. The paper constitutes a theoretical basis for future design scenarios - exemplified through visionary urban design proposals for a specific site in the city of Esbjerg, Denmark. Relocating rigs to an urban context initiates discussions of conception of...... 'Place' questioning the fixity of 'Place' (Jensen 2010). Scoped through a relational sense of place (Massey 1993) and the potential of exploring new relations between places (Burns & Kahn 2005), the paper challenges the notion of 'Place as God' (Hvattum 2010). These places in transition contest the...

  10. Understanding quantum phase transitions

    Carr, Lincoln

    2010-01-01

    Quantum phase transitions (QPTs) offer wonderful examples of the radical macroscopic effects inherent in quantum physics: phase changes between different forms of matter driven by quantum rather than thermal fluctuations, typically at very low temperatures. QPTs provide new insight into outstanding problems such as high-temperature superconductivity and display fundamental aspects of quantum theory, such as strong correlations and entanglement. Over the last two decades, our understanding of QPTs has increased tremendously due to a plethora of experimental examples, powerful new numerical meth

  11. Mexico in Transition

    Barbara Hogenboom

    2003-01-01

    – Mexico’s Politics and Society in Transition, edited by Joseph S. Tulchin and Andrew D. Selee. Boulder/London: Lynne Rienner Publishers, 2003. – México al inicio del siglo XXI: democracia, cuidadanía y desarrollo, edited by Alberto Aziz Nassif. México: CIESAS & Miguel Ángel Porrúa, 2003. – Globalización y alternativas incluyentes para el siglo XXI, edited by Jorge Basave, Alejandro Dabat, Carlos Morera, Miguel Ángel Rivera Ríos & Francisco Rodríguez. México: Instituto de Investigacio...

  12. ALICE Transition Radiation Detector

    Pachmayer, Y

    2013-01-01

    The Transition Radiation Detector (TRD) is the main electron detector in ALICE. In conduction with the TPC and the ITS, it provides the necessary electron identification capability to study: - Production of light and heavy vector mesons as well as the continuum in the di-electron channel, - Semi leptonic decays of hadrons with open charm and open beauty via the single-electron channel using the displaced vertex information provided by the ITS, - Correlated DD and BB pairs via coincidences of electrons in the central barrel and muons in the forward muon arm, - Jets with high Pτ tracks in one single TRD stack.

  13. Transition in synthetic jets

    Tesař, Václav; Kordík, Jozef

    Roč. 187, NOV 2012 ( 2012 ), s. 105-117. ISSN 0924-4247 R&D Projects: GA TA ČR(CZ) TA02020795; GA ČR(CZ) GPP101/12/P556; GA ČR(CZ) GCP101/11/J019 Institutional research plan: CEZ:AV0Z20760514 Keywords : turbulence * synthetic jet * transition * velocity spectra Subject RIV: BK - Fluid Dynamics Impact factor: 1.841, year: 2012 http://www.sciencedirect.com/science/article/pii/S0924424712005031

  14. Semiconducting transition metal oxides

    Open shell transition metal oxides are usually described as Mott or charge transfer insulators, which are often viewed as being disparate from semiconductors. Based on the premise that the presence of a correlated gap and semiconductivity are not mutually exclusive, this work reviews electronic structure calculations on the binary 3d oxides, so to distill trends and design principles for semiconducting transition metal oxides. This class of materials possesses the potential for discovery, design, and development of novel functional semiconducting compounds, e.g. for energy applications. In order to place the 3d orbitals and the sp bands into an integrated picture, band structure calculations should treat both contributions on the same footing and, at the same time, account fully for electron correlation in the 3d shell. Fundamentally, this is a rather daunting task for electronic structure calculations, but quasi-particle energy calculations in GW approximation offer a viable approach for band structure predictions in these materials. Compared to conventional semiconductors, the inherent multivalent nature of transition metal cations is more likely to cause undesirable localization of electron or hole carriers. Therefore, a quantitative prediction of the carrier self-trapping energy is essential for the assessing the semiconducting properties and to determine whether the transport mechanism is a band-like large-polaron conduction or a small-polaron hopping conduction. An overview is given for the binary 3d oxides on how the hybridization between the 3d crystal field symmetries with the O-p orbitals of the ligands affects the effective masses and the likelihood of electron and hole self-trapping, identifying those situations where small masses and band-like conduction are more likely to be expected. The review concludes with an illustration of the implications of the increased electronic complexity of transition metal cations on the defect physics and doping, using

  15. Sexuality in transit

    Heinskou, Marie Bruvik

    2015-01-01

    Through an investigation of a reported rape, this article suggests that we conceive sexuality as a transitional object that changes and transforms depending on space and temporality. This makes sexuality difficult to grasp within specific and stable frames of gender and power analysis. Applying...... such an approach, the complexities of sexual assault, changing power relations and unstable narratives of gender and sexuality are illuminated. The analysis shows that the traditional divide between public and private has dissolved and that public spaces of pop culture are drawn into spaces of intimacy...

  16. MR staging accuracy for endometrial cancer based on the new FIGO stage

    Background: Magnetic resonance imaging (MRI) has been frequently used to determine a preoperative treatment plan for gynecologic cancers. However, the MR accuracy for staging an endometrial cancer is not satisfactory based on the old FIGO staging system. Purpose: To evaluate MR accuracy for staging endometrial cancer using the new FIGO staging system. Material and Methods: Between January 2005 and May 2009, 199 women underwent surgery due to endometrial cancer. In each patient, an endometrial cancer was staged using MR findings based on the old FIGO staging system and then repeated according to the new FIGO staging system for comparison. Histopathologic findings were used as a standard of reference. Results: The accuracy of MRI in the staging of endometrial carcinoma stage I, II, III, and IV using the old FIGO staging system were 80% (159/199), 89% (178/199), 90% (179/199), and 99% (198/199), respectively, compared to 87% (174/199), 97% (193/199), 90% (179/199), and 99% (198/199), respectively, when using the new FIGO staging criteria. The overall MR accuracy of the old and new staging systems were 51% (101/199) and 81% (161/199), respectively. Conclusion: MRI has become a more useful tool in the preoperative staging of endometrial cancers using the new FIGO staging system compared to the old one with increased accuracy

  17. A translational evaluation of transitions.

    Jessel, Joshua; Hanley, Gregory P; Ghaemmaghami, Mahshid

    2016-06-01

    Transitions with nonhuman animals are typically framed as inescapable changes in signaled reinforcement schedules that result in a pause in responding unique to switches from rich to lean schedules. Pausing is considered to be a function of the aversive qualities of the contrasting reinforcement schedules. Transitions are typically framed in applied research as physical changes in location that evoke problem behavior maintained by the escape of an aversive event or resumption of a preferred event. We attempted to extend the basic framing of transitions to behaviors and contexts of social significance and evaluate a novel treatment for the problem of dawdling by 3 boys who had been diagnosed with autism spectrum disorder during rich-to-lean transitions. Dawdling during physical transitions was most readily observed when transitioning to lean contexts in Experiment 1. We then shortened transition duration in Experiment 2 by programming unsignaled and probabilistic rich reinforcement in the upcoming context. PMID:26916573

  18. Complex Nonlinearity Chaos, Phase Transitions, Topology Change and Path Integrals

    Ivancevic, Vladimir G

    2008-01-01

    Complex Nonlinearity: Chaos, Phase Transitions, Topology Change and Path Integrals is a book about prediction & control of general nonlinear and chaotic dynamics of high-dimensional complex systems of various physical and non-physical nature and their underpinning geometro-topological change. The book starts with a textbook-like expose on nonlinear dynamics, attractors and chaos, both temporal and spatio-temporal, including modern techniques of chaos–control. Chapter 2 turns to the edge of chaos, in the form of phase transitions (equilibrium and non-equilibrium, oscillatory, fractal and noise-induced), as well as the related field of synergetics. While the natural stage for linear dynamics comprises of flat, Euclidean geometry (with the corresponding calculation tools from linear algebra and analysis), the natural stage for nonlinear dynamics is curved, Riemannian geometry (with the corresponding tools from nonlinear, tensor algebra and analysis). The extreme nonlinearity – chaos – corresponds to th...

  19. A Multidisciplinary Approach for Identifying Stage-specific Transcription Factor Binding Sites in the Irish Potato Famine Pathogen, Phytophthora infestans

    Roy, Sourav

    2011-01-01

    Phytophthora infestans, an oomycete within the phylum Heterokontophyta is one of the most devastating phytopathogens, causing late blight in potato and tomato. Its pathogenic success depends on the formation of different asexual spores such as sporangia and zoospores. Our goal was to identify what regulates transition between each of the five different asexual stages viz. hyphae, spores, cleaving sporangia, swimming zoospores and germinating cysts, by understanding what determines stage-spec...

  20. Nutrition transition and obesity prevention through the life-course

    Kac, G; Pérez-Escamilla, R

    2013-01-01

    The aim of this paper is to discuss concepts regarding the nutrition transition (NT), the several stages it has encompassed over human history, dietary shifts it is associated with and its implications to the life-course approach for obesity prevention. NT is a phenomenon characterized by an inversion of the nutrition profile, that is, an increase in obesity and a reduction in undernutrition. Obesity and associated chronic diseases are the most important expressions of NT today. Some importan...

  1. Youth poverty and transition to adulthood in Europe

    Letizia Mencarini; Maria Iacovou; Arnstein Aassve

    2006-01-01

    There is an increasing amount of research focussing on the transition to adulthood, a stage of the life cycle where young people face demanding life decisions, including completion of education, finding stable employment, and establishing their household and family. Whereas there is a well-developed literature on poverty among households in general, very little research has focused on poverty among young adults. Using the European Community Household Panel (ECHP) we provide a detailed descrip...

  2. Tiber Personal Rapid Transit

    Diego Carlo D'agostino

    2011-02-01

    Full Text Available The project “Tiber Personal Rapid Transit” have been presented by the author at the Rome City Vision Competition1 2010, an ideas competition, which challenges architects, engineers, designers, students and creatives individuals to develop visionary urban proposals with the intention of stimulating and supporting the contemporary city, in this case Rome. The Tiber PRT proposal tries to answer the competition questions with the definition of a provocative idea: a Personal Rapid transit System on the Tiber river banks. The project is located in the central section of the Tiber river and aims at the renewal of the river banks with the insertion of a Personal Rapid Transit infrastructure. The project area include the riverbank of Tiber from Rome Transtevere RFI station to Piazza del Popolo, an area where main touristic and leisure attractions are located. The intervention area is actually no used by the city users and residents and constitute itself a strong barrier in the heart of the historic city.

  3. Planet Demographics from Transits

    Howard, Andrew

    2015-08-01

    From the demographics of planets detected by the Kepler mission, we have learned that there exists approximately one planet per star for planets larger than Earth orbiting inside of 1 AU. We have also learned the relative occurrence of these planets as a function of their orbital periods, sizes, and host star masses and metallicities. In this talk I will review the key statistical findings that the planet size distribution peaks in the range 1-3 times Earth-size, the orbital period distribution is characterized by a power-law cut off at short periods, small planets are more prevalent around small stars, and that approximately 20% of Sun-like stars hosts a planet 1-2 times Earth-size in a habitable zone. Looking forward, I will describe analysis of photometry from the K2 mission that is yielding initial planet discoveries and offering the opportunity to measure planet occurrence in widely separated regions of the galaxy. Finally, I will also discuss recent techniques to discover transiting planets in space-based photometry and to infer planet population properties from the ensemble of detected and non-detected transit signals.

  4. Real two-stage Kondo effect in parallel double quantum dot

    We study the two-stage Kondo effect in asymmetric parallel double quantum dots. In the triplet, the magnetic moment screenings on two dots occur at the same Kondo temperature. In the critical regime of the triplet–singlet quantum phase transition, a two-stage Kondo screening accompanied with two kinds of Kondo resonance with two energy scales is observed. This is contrast to previous works, in which the Kondo peak in the second screening has not been observed. For large asymmetry of the Kondo coupling, the Kondo resonance in the second step is very weak, which indicates that the screening occurs mainly between two dots and is not a real Kondo screening. Therefore, the side-coupled double quantum dots, which have been extensively studied in the literature, are not an ideal candidate to show a real two-stage Kondo screening. - Highlights: • A real two-stage Kondo screening is not observable in side-coupled 2 quantum dots. • A two-stage Kondo screening is observed in asymmetric parallel 2 quantum dots. • The Kosterlitz–Thouless-type quantum phase transition is studied

  5. Transesophageal ultrasonography for lung cancer staging

    Konge, Lars; Annema, Jouke; Vilmann, Peter;

    2013-01-01

    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging are...

  6. Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

    Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N;

    2013-01-01

    This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

  7. Stages of Small-Group Development Revisited

    Tuckman, Bruce W.; Jensen, Mary Ann C.

    1977-01-01

    This review examines published research on small-group development done in the last ten years that would constitute an empirical test of Tuckman's hypothesis that groups go through the stages of "forming,""storming,""norming," and "performing." A fifth stage, "adjourning," was added to the hypothesis. More empirical work was recommended. (Author)

  8. Stages of Development of Azerbaijani Romanticism

    Aynur Sabitova

    2013-01-01

    This article focuses on the most active period of romanticism in the Azerbaijan literature. The article lists the stages of development of Azerbaijani romanticism. Like any literary phenomenon the Azerbaijani romanticism has its own reference points: concrete time of origination, the stages of formation, development, giving in its positions and retirement from the literary scene. All these aspects have been analyzed.

  9. Experiments for Multi-Stage Processes

    Tyssedal, John; Kulahci, Murat

    2015-01-01

    Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize the req...... number of stages and also show how to identify and estimate the effects. Both regular and non-regular designs are considered as base designs in generating the overall design.......Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize the...... required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any...

  10. Two-stage repair in hypospadias.

    Haxhirexha, K N; Castagnetti, M; Rigamonti, W; Manzoni, G A

    2008-04-01

    We provide the reader with a nonsystematic review concerning the use of the two-stage approach in hypospadias repairs. A one-stage approach using the tubularized incised plate urethroplasty is a well-standardized approach for the most cases of hypospadias. Nevertheless, in some primary severe cases, in most hypospadias failures and in selected patients with balanitis xerotica obliterans a two-stage approach is preferable. During the first stage the penis is straightened, if necessary and the urethral plate is substituted with a graft of either genital (prepuce) or extragenital origin (oral mucosa or postauricular skin). During the second stage, performed around 6 months later, urethroplasty is accomplished by graft tubulization. Graft take is generally excellent, with only few cases requiring an additional inlay patch at second stage due to graft contracture. A staged approach allows for both excellent cosmetic results and a low morbidity including an overall 6% fistula rate and 2% stricture rate. Complications usually occur in the first year after the second stage and are higher in secondary repairs. Complications tend to decrease as experience increases and use of additional waterproofing layers contributes to reduce the fistula rate significantly. Long-term cosmetic results are excellent, but voiding and ejaculatory problems may occur in as much as 40% of cases if a long urethral tube is constructed. The procedure has a step learning curve but because of its technical simplicity does not require to be confined only to highly specialized centers. PMID:19468402

  11. Expressing Tumour Staging Using the Read Thesaurus

    Brown, Philip J. B.; Read, Graham; Price, Colin

    1996-01-01

    The expression of tumour staging is an important component of clinical care and the electronic capture of this data offers great potential. Version 3 of the Read Thesaurus includes a template table which offers a robust mechanism for applying specific staging detail to tumours within the clinical record.

  12. The Elaboration Stages of Local Development Strategies

    Márton BALOGH

    2003-01-01

    This article - “The Elaboration Stages of Local Development Strategies” - aims to present a topic of current interest for Romanian local public administrations. The author presents a possible way of elaborating local and micro-regional strategies, with emphasis on the characteristics of these documents and the stages of their application.

  13. The Elaboration Stages of Local Development Strategies

    Márton BALOGH

    2003-01-01

    Full Text Available This article - “The Elaboration Stages of Local Development Strategies” - aims to present a topic of current interest for Romanian local public administrations. The author presents a possible way of elaborating local and micro-regional strategies, with emphasis on the characteristics of these documents and the stages of their application.

  14. Properties of a two stage adiabatic demagnetization refrigerator

    Fukuda, H.; Ueda, S.; Arai, R.; Li, J.; Saito, A. T.; Nakagome, H.; Numazawa, T.

    2015-12-01

    Currently, many space missions using cryogenic temperatures are being planned. In particular, high resolution sensors such as Transition Edge Sensors need very low temperatures, below 100 mK. It is well known that the adiabatic demagnetization refrigerator (ADR) is one of most useful tools for producing ultra-low temperatures in space because it is gravity independent. We studied a continuous ADR system consisting of 4 stages and demonstrated it could provide continuous temperatures around 100 mK. However, there was some heat leakage from the power leads which resulted in reduced cooling power. Our efforts to upgrade our ADR system are presented. We show the effect of using the HTS power leads and discuss a cascaded Carnot cycle consisting of 2 ADR units.

  15. Automatic Sleep Stage Scoring Using Time-Frequency Analysis and Stacked Sparse Autoencoders.

    Tsinalis, Orestis; Matthews, Paul M; Guo, Yike

    2016-05-01

    We developed a machine learning methodology for automatic sleep stage scoring. Our time-frequency analysis-based feature extraction is fine-tuned to capture sleep stage-specific signal features as described in the American Academy of Sleep Medicine manual that the human experts follow. We used ensemble learning with an ensemble of stacked sparse autoencoders for classifying the sleep stages. We used class-balanced random sampling across sleep stages for each model in the ensemble to avoid skewed performance in favor of the most represented sleep stages, and addressed the problem of misclassification errors due to class imbalance while significantly improving worst-stage classification. We used an openly available dataset from 20 healthy young adults for evaluation. We used a single channel of EEG from this dataset, which makes our method a suitable candidate for longitudinal monitoring using wearable EEG in real-world settings. Our method has both high overall accuracy (78%, range 75-80%), and high mean [Formula: see text]-score (84%, range 82-86%) and mean accuracy across individual sleep stages (86%, range 84-88%) over all subjects. The performance of our method appears to be uncorrelated with the sleep efficiency and percentage of transitional epochs in each recording. PMID:26464268

  16. Study of blade aspect ratio on a compressor front stage aerodynamic and mechanical design report

    Burger, G. D.; Lee, D.; Snow, D. W.

    1979-01-01

    A single stage compressor was designed with the intent of demonstrating that, for a tip speed and hub-tip ratio typical of an advanced core compressor front stage, the use of low aspect ratio can permit high levels of blade loading to be achieved at an acceptable level of efficiency. The design pressure ratio is 1.8 at an adiabatic efficiency of 88.5 percent. Both rotor and stator have multiple-circular-arc airfoil sections. Variable IGV and stator vanes permit low speed matching adjustments. The design incorporates an inlet duct representative of an engine transition duct between fan and high pressure compressor.

  17. Voluntary Transition of the CEO: Owner CEOs’ Sense of Self Before, During and After Transition

    Randy T. Byrnes

    2015-10-01

    Full Text Available This inductive study explores how former business owner chief executive officers (CEOs experience sense of self during voluntary separation and transition from their company. Our inquiry engaged 16 CEOs who ran companies ranging in size from 15 to 500 employees as they detailed their stories of walking away from roles as owner CEOs. We developed a coding scheme to analyze themes manifested in the narratives. We also analyzed the former CEOs’ narratives using a stage and valence model depicting both the continuum of the separation experience and the characterization of each stage as a positive or negative state of being. The diverse yet synchronous stories resulted in three implications for current owner CEOs, professionals who advise CEOs, and future research on CEOs’ careers. First, the CEOs often failed to allocate sufficient time and effort to prepare for an identity shift following the sale of their company or transition into retirement. Second, the CEOs experienced a diminished sense of self and dissatisfaction with the exit event. Third, the majority of the CEOs demonstrated an ability to work through the adverse and unanticipated states of being into a positive sense of self.

  18. Voluntary transition of the CEO: owner CEOs' sense of self before, during and after transition.

    Byrnes, Randy T; Taylor, Scott N

    2015-01-01

    This inductive study explores how former business owner chief executive officers (CEOs) experience sense of self during voluntary separation and transition from their company. Our inquiry engaged 16 CEOs who ran companies ranging in size from 15 to 500 employees as they detailed their stories of walking away from roles as owner CEOs. We developed a coding scheme to analyze themes manifested in the narratives. We also analyzed the former CEOs' narratives using a stage and valence model depicting both the continuum of the separation experience and the characterization of each stage as a positive or negative state of being. The diverse yet synchronous stories resulted in three implications for current owner CEOs, professionals who advise CEOs, and future research on CEOs' careers. First, the CEOs often failed to allocate sufficient time and effort to prepare for an identity shift following the sale of their company or transition into retirement. Second, the CEOs experienced a diminished sense of self and dissatisfaction with the exit event. Third, the majority of the CEOs demonstrated an ability to work through the adverse and unanticipated states of being into a positive sense of self. PMID:26579018

  19. DNS Study on Physics of Late Boundary Layer Transition

    Liu, Chaoqun

    2014-01-01

    This paper serves as a review of our recent new DNS study on physics of late boundary layer transition. This includes mechanism of the large coherent vortex structure formation, small length scale generation and flow randomization. The widely spread concept vortex breakdown to turbulence,which was considered as the last stage of flow transition, is not observed and is found theoretically incorrect. The classical theory on boundary layer transition is challenged and we proposed a new theory with five steps, i.e. receptivity, linear instability, large vortex formation, small length scale generation, loss of symmetry and randomization to turbulence. We have also proposed a new theory about turbulence generation. The new theory shows that all small length scales (turbulence) are generated by shear layer instability which is produced by large vortex structure with multiple level vortex rings, multiple level sweeps and ejections, and multiple level negative and positive spikes near the laminar sub-layers.Therefore,...

  20. Irradiated survival effect of melanoma B16 cells at different penetration depths of intermediate energy heavy-ion beams%中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应

    李强; 周光明; 王菊芳; 李文建; 温小琼; 党秉荣; 颉红梅; 卫增泉

    2001-01-01

    Survival fractions of melanoma B16 cells at different penetrationdepths exposed to 49.30MeV/u 12C ion beam and modulated 74.55MeV/u 12C ion beam with a ridge filter to form a spread-out Bragg peak (SOBP) were measured. The results show the survival response of B16 cells as the biological endpoint to heavy ions increases synchronously with the deposited energy along the beam traversal, that is, the survival fraction near or at the Bragg peak or SOBP is far lower than that at the beam's entrance or exit channel. Comparisons of the experimental data with calculated survival fractions at different depths predicted by the linear-quadratic survival model combined with dose-averaged LET display a good agreement within the experimental errors. It is prompted that the linear-quadratic model combined with dose-averaged LET possibly is a valid way to calculate the survival effect of B16 cells along the beam penetration under the exposure of the intermediate energy heavy-ion beam.%测量了49.30MeV/u及经脊形过滤器展宽的Bragg峰的74.55MeV/u12C离子束在不同贯穿深度上辐射后黑色素瘤B16细胞的存活率。结果显示,以存活为终点的B16细胞生物学效应与碳离子束能量沉积同步增大,即Bragg或展宽的Bragg峰区内细胞存活率远低于离子束入射或出射通道处的细胞存活率。通过实验测量与剂量平均LET结合的线性平方模型理论计算存活曲线的比较,发现在实验测量误差范围内两者符合较好。提示:剂量平均LET结合线性平方模型可能是预测中能重离子束贯穿深度上B16细胞存活效应的一种有效的方法。

  1. The effects of platelet P-selectin on tumor necrosis factor-α and vascular endothelial growth factor secreted by B16 cells%血小板上表达的P-选择素对B16细胞分泌肿瘤坏死因子和血管内皮生长因子的影响

    亓翠玲; 郭四美; 叶杰; 周秦; 郑力; 王丽京

    2012-01-01

    Objective To investigate the effects of platelet P - selectin on tumor necrosis factor - α and vascular endothelial growth factor secreted by B16 cells. Methods The B16 cells were co - cultured with the platelets from C57 mice and P - selectin knockout mice. The TNF -α and VEGF concentrations in the supernatant were assessed using ELISA. Results The VEGF concentration was significantly higher in C57 group than that in P - selectin knockout group, though there was no significant difference in TNF - α. Conclusion Platelet P - selectin promotes B16 cells lo secrete VEGF, but with no effect on TNF - α%目的 探讨血小板上表达的P-选择素对B16细胞分泌肿瘤坏死因子(tumor necrosis factor-α,TNF-α)和血管内皮生长因子(vascular endothelial growth factor,VEGF)的影响.方法 将B16细胞分别与C57小鼠和P-选择素敲除小鼠的血小板共培养,用ELISA法检测上清中的肿瘤坏死因子和血管内皮生长因子的浓度.结果 B16细胞与C57小鼠的血小板共培养的血清中血管内皮生长因子的浓度明显高于与P-选择素敲除小鼠的血小板共培养的血清中的浓度,差异有统计学意义(P<0.05),而肿瘤坏死因子的浓度差异无统计学意义.结论 血小板上表达的P-选择素促进了B16细胞分泌血管内皮生长因子,但对肿瘤坏死因子的分泌则没有影响.

  2. Arguing on entropic and enthalpic first-order phase transitions in strongly interacting matter

    Wunderlich, Falk; Kampfer, Burkhard

    2016-01-01

    The pattern of isentropes in the vicinity of a first-order phase transition is proposed as a key for a sub-classification. While the confinement--deconfinement transition, conjectured to set in beyond a critical end point in the QCD phase diagram, is often related to an entropic transition and the apparently settled gas-liquid transition in nuclear matter is an enthalphic transition, the conceivable local isentropes w.r.t.\\ "incoming" or "outgoing" serve as another useful guide for discussing possible implications, both in the presumed hydrodynamical expansion stage of heavy-ion collisions and the core-collapse of supernova explosions. Examples, such as the quark-meson model and two-phase models, are shown to distinguish concisely the different transitions.

  3. Numerical simulation of transitions between back discharge regimes

    Jánský, Jaroslav; Bessières, Delphine; Paillol, Jean; Lemont, Florent

    2014-11-01

    This paper presents numerical simulations of transitions between back discharge regimes. Back discharge refers to any discharge initiated at or near a dielectric layer covering a passive electrode. In this work, a pinhole in a dielectric layer on a plane anode serves as a model for back discharge activity. We have studied transitions between back discharge regimes by varying the surface charge density on the dielectric layer and the electric field in front of the pinhole. From the variation of these two independent parameters, the back discharge regimes have been depicted as a mode diagram inspired by the experimental study of Masuda and Mizuno. The resulting diagram includes the different discharge regimes that are commonly observed in experiments. The propagation of a positive ionizing wave inside the pinhole toward its edge, and the resulting formation of a plasma zone at its exit constitute the onset stage of back discharge. From this stage, the transitions to volume discharge or surface discharge can occur. The volume discharge regime consists of the propagation of a discharge in space toward the cathode which can be superimposed with the propagation of a discharge above the dielectric layer surface. The diagram reveals the conditions for transitions between back discharge regimes.

  4. Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

    Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin;

    2001-01-01

    Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non......-reactive bubble point calculations is proposed. This strategy tracks the conversion and temperature between the feed and the end stages of the column. An illustrative example highlights the verification of the design strategy through rigorous simulation....

  5. The electricity market in transition: a decoding

    A set of article proposes a discussion of the main challenges for energy transition for the architecture of the European electricity market, an interview of the responsible of the energy department within the French ministry of ecology (she addresses the issues of market, electricity system, renewable energies), a discussion of the first lessons learned from the integration of renewable energies in the electricity market, a comment on hazardous evolutions for independent producers, a discussion of the pilot stage for bidding in Germany, a discussion of false ideas and true challenges in the relationship between demand management and integration, a comment on the evolution towards a complete reform of the support system for renewable energies, and a discussion of the perspectives beyond 40 per cent of renewable energies in the French electricity mix

  6. Transition to management -- A personal perspective

    Williams, J.L.

    1998-02-01

    This paper explores one woman`s journey through her recent promotion into management, and will identify key factors that helped prepare and position her to be ready to exercise leadership through a formal management role. It discusses assessment of qualifications and skills, acquisition of needed skills, the influence of luck and timing, and the use of mentors and delegation as survival skills to get through the transition period and become fully functional as a manager. It also includes insights into sensitive issues such as how to relate to former peers, how to gain credibility as the junior member of the management team, and how to juggle family responsibilities with increased time commitments at work. It emphasizes the importance of acknowledging the help the authors receive in reaching their own career goals and offering the same kind of help and support to those in the early stages of their careers.

  7. Invariant probabilities of transition functions

    Zaharopol, Radu

    2014-01-01

    The structure of the set of all the invariant probabilities and the structure of various types of individual invariant probabilities of a transition function are two topics of significant interest in the theory of transition functions, and are studied in this book. The results obtained are useful in ergodic theory and the theory of dynamical systems, which, in turn, can be applied in various other areas (like number theory). They are illustrated using transition functions defined by flows, semiflows, and one-parameter convolution semigroups of probability measures. In this book, all results on transition probabilities that have been published by the author between 2004 and 2008 are extended to transition functions. The proofs of the results obtained are new. For transition functions that satisfy very general conditions the book describes an ergodic decomposition that provides relevant information on the structure of the corresponding set of invariant probabilities. Ergodic decomposition means a splitting of t...

  8. Strategic planning in transition

    Olesen, Kristian; Richardson, Tim

    2012-01-01

    In this paper, we analyse how contested transitions in planning rationalities and spatial logics have shaped the processes and outputs of recent episodes of Danish ‘strategic spatial planning’. The practice of ‘strategic spatial planning’ in Denmark has undergone a concerted reorientation in the...... recent years as a consequence of an emerging neoliberal agenda promoting a growth-oriented planning approach emphasising a new spatial logic of growth centres in the major cities and urban regions. The analysis, of the three planning episodes, at different subnational scales, highlights how this new...... style of ‘strategic spatial planning’ with its associated spatial logics is continuously challenged by a persistent regulatory, top-down rationality of ‘strategic spatial planning’, rooted in spatial Keynesianism, which has long characterised the Danish approach. The findings reveal the emergence of a...

  9. Radioisotope esophageal transit test

    A new technique employed sup(99m)Tc-MAA for the study of esophageal dysfunction and its clinical implication were evaluated in the patients with achalasia, progressive systemic sclerosis, reflux esophagitis and 10 normal controls. To investigate esophageal emptying and gastroesophageal reflux, a homogeneous bolus of sup(99m)Tc-MAA in 15ml of water was swallowed in the upright and supine positions under the collimeter of a gamma camera linked to nuclear medicine data analyser (Shimazu Scinti Pack 1200). This radionuclide transit studies made a quantitative evaluation of the esophageal dysfunction possible in all cases. Comparing the conventional esophageal function test procedures, this test is a safe, noninvasive and more physiological and sensitive in detecting abnormal esophageal emptying and gastroesophageal reflux. (author)

  10. Transit spectroscopy with GTC

    Osorio M.R. Zapatero

    2013-04-01

    Full Text Available Thanks to different ground-based surveys and space missions, nowadays we have a fairly large sample of discovered extra-solar planets to study and, without a doubt, this number will increase in the future. One of the most succesful techniques that allows us to prove the physical properties and atmospheric composition of these exoplanets is transmission spectroscopy. The level of precision that is require to measure these effects provides a technical challenge that is solved by using big telescopes and stable instruments to reach low noise levels. In this article, we will discuss the use of the 10m class telescope GTC to observed planetary transits in spectroscopic mode and some of the results that we are currently obtaining.

  11. Energy transition in action

    By presenting examples and experiments implemented in France, this publication illustrates the various ways to translate the objectives of energy transition into practical actions. A first part addresses the building sector and shows how to better renovate buildings: exemplary rehabilitations, techniques of construction to decrease energy consumption and equipment to control it, insulation by vegetal fibres, control of consumption decrease. The second part addresses the development of renewable energies: a heat network for household heating, innovative use of biogas, production of hot water by using solar energy, a waste incineration plant, heating by using waste waters. The third part addresses the promotion of circular economy: a recycling project, an optics-based glass sorting system, the commitment of Parisian restaurateurs for waste valorisation, a plant for waste sorting and valorisation

  12. Probiotics in transition.

    Shanahan, Fergus; Dinan, Timothy G; Ross, Paul; Hill, Colin

    2012-11-01

    Despite the hyperbole often linked with a popular research field, the scientific rationale for probiotics is sound. The probiotic concept is not new but is undergoing transition as knowledge of the gut microbiota in health and disease becomes translated to the clinic. Operationally, a probiotic represents a mimic of and/or supplement to the normal gut microbiota. Much confusion has arisen among consumers because of media misportrayals of probiotics as all being the same. However, with clarification of the molecular basis of host-microbe interactions, the selection criteria for probiotics and the delineation of their distinct mechanisms of action are improving. Most probiotics are from the genus Lactobacillus or Bifidobacterium; this is likely to change and diversify. Similarly, the development of new therapeutic strategies, such as the development of phagebiotics, psychobiotics, and genetically modified pharmabiotics, is poised to become a therapeutic reality. PMID:23010563

  13. Maritime in transit care.

    Bott, G; Barnard, J; Prior, K

    2015-01-01

    Operation GRITROCK saw the first operational deployment of the Maritime In Transit Care team from the Role 2 (Enhanced) (R2(E)) Medical Treatment Facility, which is able to provide Damage Control Surgery and the limited holding of patients, situated on board RFA ARGUS. Whilst the Medical Emergency Response Team demonstrated the capability of advanced military Pre-Hospital Emergency Care (PHEC) on Op HERRICK, the need to provide a similar high level of care on contingency operations was recognised. Op GRITROCK allowed for the continued exploration of a maritime capability from an established R2(E) platform whilst providing medical evacuation capability for a significant population at risk distributed over a large Joint Operation Area. Although the patient load during the operation was low, key lessons were learnt and opportunities identified to further develop the newly recognised sub-speciality of PHEC, both medically and logistically, and these will be discussed in this article. PMID:26867404

  14. Nuclear regulation in transition

    The current state of nuclear regulations in the USA is examined. Since Three Mile Island the regulation of the nuclear power industry has been undergoing a noticeable transition. It will be argued here that the transition is characterized by two indicia. First, the primary focus of state and federal regulators has been on the financial aspects of the industry: this is best seen in the context of decisions allocating the costs of nuclear plant cancellations. Second, decisionmaking power has been decentralized: although the regulatory history of nuclear power demonstrates the tradition of centralized decisionmaking power (i.e., formerly the primary decisionmaking body was the Atomic Energy Commission), now States share decisionmaking power with the Nuclear Regulatory Commission. In Section 1 a brief legislative history of nuclear regulation is presented to establish the assertion that nuclear regulation, both de jure and de facto, was centralized. Next, Section 2 canvasses recent United States Supreme Court opinions regarding nuclear regulation. The Court frequently acts as policymaker through the consequences of its opinions, if not by its intent. In the area of nuclear policymaking, the Court has paid allegiance recently both to the tradition of centralization and to the movement toward decentralization. This dualism is reflected in other federal court decisions as well which will be briefly mentioned. Continuing the analysis of Federal regulation, Section 3 examines the current reform efforts of the NRC. Section 4 presents an examination of State responses to nuclear plant cancellations. In this section, State administrative agency and court decisions will be examined and recent State legislation will be discussed. (author)

  15. Experience Transitioning Models and Data at the NOAA Space Weather Prediction Center

    Berger, Thomas

    2016-07-01

    The NOAA Space Weather Prediction Center has a long history of transitioning research data and models into operations and with the validation activities required. The first stage in this process involves demonstrating that the capability has sufficient value to customers to justify the cost needed to transition it and to run it continuously and reliably in operations. Once the overall value is demonstrated, a substantial effort is then required to develop the operational software from the research codes. The next stage is to implement and test the software and product generation on the operational computers. Finally, effort must be devoted to establishing long-term measures of performance, maintaining the software, and working with forecasters, customers, and researchers to improve over time the operational capabilities. This multi-stage process of identifying, transitioning, and improving operational space weather capabilities will be discussed using recent examples. Plans for future activities will also be described.

  16. Transition Complexity of Incomplete DFAs

    Yuan Gao; Kai Salomaa; Sheng Yu

    2010-01-01

    In this paper, we consider the transition complexity of regular languages based on the incomplete deterministic finite automata. A number of results on Boolean operations have been obtained. It is shown that the transition complexity results for union and complementation are very different from the state complexity results for the same operations. However, for intersection, the transition complexity result is similar to that of state complexity.

  17. Transition management: origin, evolution, critique

    Rotmans, Jan; Loorbach, Derk; Kemp, René

    2007-01-01

    textabstractTransition management has rapidly emerged over the past few years as a new approach to dealing with complex societal problems and governance in the context of these problems. In the Netherland, UK and Belgium, serious efforts have been and are being undertaken to develop transition policies in areas such as energy, building, mobility and water management. This is the result of a much broader scientific development of transition research as an interdisciplinary field of study in wh...

  18. México: elected transition

    Mauricio MERINO HUERTA

    2010-01-01

    The results of the Mexican federal elections of July 2000 raised new questions for those interested in transitions. In contrast to the South American, East-European, and South European experiences –that have produced a rich literature on the subject–, political changes in Mexico are not easily placed within the existing theoretical frameworks. This paper aims at contrasting the ideal model of transition and the real Mexican transition. The argument focuses on three differences: instead of a t...

  19. Evolution of quantum field, particle content and classicality in the three stage universe

    Singh, Suprit; Padmanabhan, T

    2013-01-01

    We study the evolution of a quantum scalar field in a toy universe which has three stages of evolution, viz., (i) an early (inflationary) de Sitter phase (ii) radiation dominated phase and (iii) late-time (cosmological constant dominated) de Sitter phase. Using Schr\\"odinger picture, the scalar field equations are solved separately for the three stages and matched at the transition points. The boundary conditions are chosen so that field modes in the early de Sitter evolves from Bunch-Davies vacuum state. We determine the (time-dependent) particle content of this quantum state for the entire evolution of the universe and describe the various features both numerically and analytically. We also describe the quantum to classical transition in terms of a {\\it classicality parameter} which tracks the particle creation and its effect on phase space correlation of the quantum field.

  20. Multi-stage sampling in genetic epidemiology.

    Whittemore, A S; Halpern, J

    When data are expensive to collect, it can be cost-efficient to sample in two or more stages. In the first stage a simple random sample is drawn and then stratified according to some easily measured attribute. In each subsequent stage a random subset of previously selected units is sampled for more detailed observation, with a unit's sampling probability determined by its attributes as observed in the previous stages. These designs are useful in many medical studies; here we use them in genetic epidemiology. Two genetic studies illustrate the strengths and limitations of the approach. The first study evaluates nuclear and mitochondrial DNA in U.S. blacks. The goal is to estimate the relative contributions of white male genes and white female genes to the gene pool of African-Americans. This example shows that the Horvitz-Thompson estimators proposed for multi-stage designs can be inefficient, particularly when used with unnecessary stratification. The second example is a multi-stage study of familial prostate cancer. The goal is to gather pedigrees, blood samples and archived tissue for segregation and linkage analysis of familial prostate cancer data by first obtaining crude family data from prostate cancer cases and cancer-free controls. This second example shows the gains in efficiency from multi-stage sampling when the individual likelihood or quasilikelihood scores vary substantially across strata. PMID:9004389

  1. [New TNM Staging System for Thymic Malignancies].

    Fukui, Takayuki; Yokoi, Kohei

    2016-05-01

    In patients with malignant tumors, the TNM classification has been widely used by clinicians as a guide for estimating prognosis, and is the basis for treatment decisions. Recently, the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and the International Thymic Malignancy Interest Group have proposed a new classification for thymic malignancies to be included in the next official staging system of the forthcoming 8th edition of the TNM classification. In this study, we reviewed 154 consecutive patients with thymic epithelial tumors who underwent complete resection at our institution, and compared their characteristics and outcomes when classified according to the proposed system with those when classified under the current Masaoka-Koga system. The proportion of patients with stage I disease increased markedly to 77.3%under the proposed system because a certain number of patients with Masaoka-Koga stages II and III diseases were downstaged to the new stage I. Regarding histology, among 69 patients with type A, AB, or B1 thymoma, 68 tumors(99%)were diagnosed as new stage I disease. When using the proposed system, the recurrence-free survival rates showed significant deterioration with increasing stage, while the overall survival rates did not. Although the new TNM classification does not serve as an effective prognostic prediction model for overall survival, it appears to offer some benefit, especially in the analysis of recurrence-free survival. PMID:27210081

  2. Migration transition in small Northern and Eastern Caribbean states.

    Mcelroy, J L; De Albuquerque, K

    1988-01-01

    1 area of intra-Caribbean migration that has been overlooked is the "migration transition"--the transformation of rapidly modernizing societies from net labor exporters to net labor importers. This article assembles 8 case studies to 1) briefly present a spectrum of migration experiences in the Caribbean, 2) uncover some transitions under way, 3) pinpoint the forces that underlie the migration transition, and 4) point out some of the more important policy implications of labor migration reversals. The 8 island societies sampled for illustration purposes include 1) the Bahamas and the US Virgin Islands as post-migration transition societies (Zelinsky's advanced society), 2) the British Virgin Islands and the Cayman Islands as undergoing transition (Zelinsky's late transitional society), and 3) Anguilla, St. Kitts-Nevis, Turks and Caicos, and Montserrat as premigration transition societies (Zelinsky's early transitional society). Population data for the islands were derived primarily from the West Indian censuses and government statistics. These 8 historical sketches reveal certain commonalities. All are at various stages in a long-term economic restructuring to displace traditional staple crops with more income elastic, high value export services. In such societies, population growth and progress along the migration transition is an increasing function of this kind of successful export substitution. In addition, along the migration and economic transitions, such insular economies exhibit a relatively large public sector (20-30% of all activity), declining unemployment, increasing fiscal autonomy, and are committed to a development strategy remarkably similar to the "successful" model of the Bahamas and the US Virgin Islands. Cursory evidence suggests that, because of intersectoral competition for land and labor, there is an inverse relationship between farm effort/manufacturing employment and tourism intensity. This review suggests that small islands undergoing

  3. Narratives about labour market transitions

    Cort, Pia; Thomsen, Rie

    2014-01-01

    flexicurity and its implications for labour market transitions, little attention has been paid to the views and experiences of the individuals concerned. The aim of this article is to connect the grand narrative with individual narratives about labour market transitions in the Danish flexicurity system. On...... the basis of narrative interviews with skilled workers, this article explores how labour market transitions are experienced by the individual and the role played by national support structures in the individual narratives. The article shows how, for the individual, a transition may prove to be a...

  4. Optical transitions in semiconductor nanostructures

    Rupasov, Valery I. [ALTAIR Center LLC, Shrewsbury, MA 01545 (United States) and Landau Institute for Theoretical Physics, Moscow (Russian Federation)]. E-mail: rupasov@townisp.com

    2007-03-19

    Employing the Maxwell equations and conventional boundary conditions for the radiation field on the nanostructure interfaces, we compute the radiative spontaneous decay rate of optical transitions in spherical semiconductor nanocrystals, core-shell nanocrystals and nanostructures comprising more than one shell. We also show that the coupling between optical transitions localized in the shell of core-shell nanocrystals and radiation field is determined by both conventional electro-multipole momenta and electro-multipole 'inverse' momenta. The latter are proportional to the core radius even for interband transitions that should result in very strong optical transitions.

  5. Optical transitions in semiconductor nanostructures

    Employing the Maxwell equations and conventional boundary conditions for the radiation field on the nanostructure interfaces, we compute the radiative spontaneous decay rate of optical transitions in spherical semiconductor nanocrystals, core-shell nanocrystals and nanostructures comprising more than one shell. We also show that the coupling between optical transitions localized in the shell of core-shell nanocrystals and radiation field is determined by both conventional electro-multipole momenta and electro-multipole 'inverse' momenta. The latter are proportional to the core radius even for interband transitions that should result in very strong optical transitions

  6. Stage-specific immune dysregulation in multiple sclerosis.

    Segal, Benjamin M

    2014-08-01

    A large body of data indicates that multiple sclerosis (MS) is an autoimmune disease which is initiated by CD4(+) T-helper 1 (Th1) and Th17 cells that are reactive against proteins in the myelin sheath. MS typically begins with a relapsing-remitting course, punctuated by clinical exacerbations associated with the development of focal inflammatory lesions in central nervous system white matter, followed by a secondary progressive (SP) phase, characterized by a gradual accumulation of neurological disability associated with widespread microglial activation and axonal loss. The molecular and cellular basis for this transition is unclear, and the role of inflammation during the SP stage is a subject of active debate. As of now, no immunological biomarkers have been identified in MS that are predictive of the clinical course or therapeutic responsiveness to disease-modifying agents, or that correlate with new lesion development, cumulative lesion load, or degree of disability. The discovery of such biomarkers would greatly facilitate clinical management and provide power for smaller and shorter clinical trials. In this article, we discuss the literature on immunological biomarkers in MS with a focus on stage-specific differences and similarities. PMID:25084180

  7. Staging lung cancer: role of endobronchial ultrasound

    Inage T

    2014-11-01

    Full Text Available Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinoscopy is known to be a highly sensitive procedure for mediastinal staging and has been performed worldwide, but is invasive. Because of this, clinicians have sought a less invasive modality for nodal staging. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA is a minimally invasive modality for diagnosis and staging of lung cancer. EBUS-TBNA is a needle biopsy procedure that has accessibility compatible with the reach of the convex-probe EBUS scope, so N1 nodes are also assessable. The diagnostic yield is similar to that of mediastinoscopy, and the core obtained by the dedicated needle biopsy can be used for histological assessment to determine the subtypes of lung cancer. The samples can also be used to test for various biomarkers using immunohistochemistry, polymerase chain reaction for DNA/complementary DNA, and in situ hybridization, and the technique is useful for selecting candidates for specific molecular-targeted therapeutic agents. According to the newly published American College of Chest Physicians guideline, EBUS-TBNA is now considered "the best first test" for nodal staging in patients with radiologically suspicious nodes. Appropriate training and thorough clinical experience is required to be able to perform correct nodal staging using this procedure. Keywords: lung cancer, staging, endobronchial ultrasound, transbronchial biopsy

  8. A set of stage-specific gene transcripts identified in EK stage X and HH stage 3 chick embryos

    Cho Seoae; Moon Sunjin; Park Tae; Kim Heebal; Lee Bo; Park Taesung; Lim Jeong; Han Jae

    2007-01-01

    Abstract Background The embryonic developmental process in avian species is quite different from that in mammals. The first cleavage begins 4 h after fertilization, but the first differentiation does not occur until laying of the egg (Eyal-Giladi and Kochav (EK) stage X). After 12 to 13 h of incubation (Hamburger and Hamilton (HH) stage 3), the three germ layers form and germ cell segregation in the early chick embryo are completed. Thus, to identify genes associated with early embryonic deve...

  9. Two-stage laser burning of stable holes in absorption spectra of organic molecules. 2. Perylene in boric acid

    Frequency-selective two-stage hole burning in the absorption spectrum of perylene in boric acid is detected and investigated at helium temperatures. A pulsed dye laser whose radiation frequency corresponded to the frequency of the 0--0 transition of perylene was used to achieve two-stage excitation by the singlet level system. The photochemical reaction responsible for the burning effect is two-quantum photoionization. The absorption spectrum of the photochemical product---the perylene cation-radical---was recorded. The photochemical reaction is irreversible. According to estimates the quantum efficiency of the burning process in the second excitation stage is ∼0.1--1

  10. Classification, staging and radiotherapy of bronchial carcinoma

    This thesis reports a study performed to evaluate the stage classification of bronchial carcinoma published by Thomas in 1963. The study was done in the radiotherapy department of a teaching hospital, and had three parts: a comparative analysis of the classifications and stage divisions described in the literature on bronchial carcinoma; an evaluation of the theoretical basis of the classification system introduced by Thomas as well as of the practical applicability of the division into stages, with respect to the assessment of the prognosis and the choice of therapy; and an analysis of various aspects of irradiation as well as of a number of prognostic factors in bronchial carcinoma. (Auth.)

  11. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  12. Innovation policy for the Dutch energy transition Operationalising transition management?

    D.A. Loorbach (Derk); R. Kemp (René)

    2005-01-01

    textabstractThe term transition is a key term of the fourth national environmental policy plan (NMP4, 2001), which put forward transition management (Rotmans et al, 2000) as a new policy approach for dealing with persistent and highly complex societal problems such as climate change, loss of biodive

  13. Spontaneous and amplified radiation at the initial stage of a SASE FEL

    At the initial stage of a self-amplified spontaneous emission (SASE) free-electron laser (FEL), spontaneous undulator radiation in certain experimental configurations can dominate the amplified signal over an extended undulator distance. In this paper they study both the spontaneous and the amplified radiation in the framework of the paraxial wave equation and determine the transition from the dominance of spontaneous emission to exponential amplification. They compare theoretical expectations with SASE simulation codes GINGER and GENESIS

  14. Cancer Prevention Among Adults Aged 45–64 Years: Setting the Stage

    Marcia G. Ory; Anderson, Lynda A.; Friedman, Daniela B.; Pulczinski, Jairus C.; Eugene, Nola; Satariano, William A

    2014-01-01

    As part of setting the stage for this supplement to the American Journal of Preventive Medicine, a life-course perspective is presented to assist in understanding the importance of cancer prevention for adults in midlife, a period roughly spanning 20 years between ages 45 and 64 years. Drawing on disciplinary perspectives from the social sciences and public health, several life-course themes are delineated in this article: how specific life transitions present unique opportunities for interve...

  15. Network dynamics during the different stages of hallucinations in schizophrenia.

    Lefebvre, Stéphanie; Demeulemeester, Morgane; Leroy, Arnaud; Delmaire, Christine; Lopes, Renaud; Pins, Delphine; Thomas, Pierre; Jardri, Renaud

    2016-07-01

    The majority of patients with schizophrenia suffer from hallucinations. While the triple-network model, which includes the default mode network (DMN), the central executive network (CEN) and the salience network (SAL), has recently been applied to schizophrenia, how this framework could explain the emergence of hallucinations remains unclear. Therefore, complementary brain regions that have been linked to hallucinations, such as the left hippocampus, should also be considered and added to this model. Accordingly, the present study explored the effective connectivity across these four components (i.e., the quadripartite model) during the different stages of hallucinations. Twenty-five patients with schizophrenia participated in a single session of resting-state functional magnetic resonance imaging to capture hallucinatory experiences. Based on the participants' self-report of the psychosensory experiences that occurred during scanning, hallucinatory experiences were identified and divided into four stages: periods without hallucination ("OFF"), periods with hallucination ("ON"), transition periods between "OFF" and "ON", and the extinction of the hallucinatory experience ("END"). Using stochastic dynamic causal modeling analysis, this study first confirmed that the SAL played a critical and causal role in switching between the CEN and the DMN in schizophrenia. In addition, effective connectivity within the quadripartite model depended on the hallucinatory stage. In particular, "ON" periods were linked to memory-based sensory input from the hippocampus to the SAL, while "END" periods were associated with a takeover of the CEN in favor of a voluntary process. Finally, the pathophysiological and therapeutic implications of these findings are critically discussed. Hum Brain Mapp 37:2571-2586, 2016. © 2016 Wiley Periodicals, Inc. PMID:27016153

  16. Design considerations for single-stage and two-stage pneumatic pellet injectors

    Performance of single-stage pneumatic pellet injectors is compared with several models for one-dimensional, compressible fluid flow. Agreement is quite good for models that reflect actual breech chamber geometry and incorporate nonideal effects such as gas friction. Several methods of improving the performance of single-stage pneumatic pellet injectors in the near term are outlined. The design and performance of two-stage pneumatic pellet injectors are discussed, and initial data from the two-stage pneumatic pellet injector test facility at Oak Ridge National Laboratory are presented. Finally, a concept for a repeating two-stage pneumatic pellet injector is described. 27 refs., 8 figs., 3 tabs

  17. Transient three-dimensional side-loads analysis of a thrust-optimized parabolic nozzle during staging

    Jia, Ruyan; Jiang, Zhenyu; Zhang, Weihua

    2016-05-01

    The objective of this effort is to numerically investigate side-loads and correlative flow physics of a thrust-optimized parabolic nozzle during the fire-in-the-hole staging event. The three-dimension transient flow in nozzle is examined by the time-accurate numerical method with time-varying chamber pressure and separation gap width. The main properties (amplitude, phase position and frequency) of computed side-loads were also analyzed. The ordinary nozzle flow separation patterns, free shock separation (FSS) and restricted shock separation (RSS), were obtained. The transition processes from FSS to RSS and finally full flow during staging event were specially emphasized. As the simulation results presented, two types of asymmetric flow physics incur strong side-loads: random transition between FSS and partial quasi-RSS due to fish tailing effect of the supersonic jet, axial flow oscillation across the nozzle lip due to relative movement between supersonic jet and front edge of the lower stage. Side-loads caused by fish tailing effect and lip oscillation have equivalent maximum amplitudes but almost perpendicular directions, while the frequency of the former is much higher than that of the latter. The side-loads due to asymmetric flow separation in the thrust-optimized parabolic nozzle are significantly intensified by the obstruction of the lower-stage dome during the staging event. Therefore, the side-loads influence should be carefully considered in advanced upper-stage nozzle of thrust-optimized parabolic contour when involving with staging.

  18. How Are Lung Carcinoid Tumors Staged?

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » How are lung carcinoid tumors staged? Share this Page Close Push escape to close share window. Print ...

  19. Synthesis of Cyclotetramethlene Tetranitramine by Three Stage

    Balwant Singh

    1982-10-01

    Full Text Available A three stage method has been developed for the preparation of cyclotetramethylene tetranitramine (HMX at 45+- 3 degree centigrade. Hexamine was nitrated to 1,5 methylene-3,7 dinitro-1,3,5,7 tetra aza cyclo octane (DPT in acetic anhydride and acetic acid ammonium nitrate -nitric acid mixture in presence of BF/sub3/ as catalyst, DPT along with reaction mixture was further treated with excess of nitric acid and acetic anhydride in the second stage. The product so obtained was converted into HMX in third stage treating with ammonium nitrate-nitric acid mixture and acetic anhydride. Effect of various concentration of ammonium nitrate, nitric acid and acetic anhydride was also studied on the yield of HMX in final stage.

  20. Stages as models of scene geometry.

    Nedović, Vladimir; Smeulders, Arnold W M; Redert, André; Geusebroek, Jan-Mark

    2010-09-01

    Reconstruction of 3D scene geometry is an important element for scene understanding, autonomous vehicle and robot navigation, image retrieval, and 3D television. We propose accounting for the inherent structure of the visual world when trying to solve the scene reconstruction problem. Consequently, we identify geometric scene categorization as the first step toward robust and efficient depth estimation from single images. We introduce 15 typical 3D scene geometries called stages, each with a unique depth profile, which roughly correspond to a large majority of broadcast video frames. Stage information serves as a first approximation of global depth, narrowing down the search space in depth estimation and object localization. We propose different sets of low-level features for depth estimation, and perform stage classification on two diverse data sets of television broadcasts. Classification results demonstrate that stages can often be efficiently learned from low-dimensional image representations. PMID:20634560

  1. Konkurss "Sony Jazz Stage" otsib uusi talente

    2006-01-01

    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt. www.jazzkaar.ee)

  2. Stages of Lip and Oral Cavity Cancer

    ... common treatment for all stages of lip and oral cavity cancer. Surgery may include the following: Wide local excision : Removal ... cancer may have spread from the lip and oral cavity. Plastic surgery : An operation that restores or improves the appearance ...

  3. Staged Financing in Venture capital market.

    Damania, Priti

    2009-01-01

    The report shows the venture capital decision making in staged financing from a real option perspective. The report also describes entrepreneur-venture capital relationship from a prisoner's dilemma approach.

  4. Modeling the three stages in HIV infection.

    Hernandez-Vargas, Esteban A; Middleton, Richard H

    2013-03-01

    A typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progression to AIDS. Simulation results illustrate how chronic infected macrophages can explain the progression to AIDS provoking viral explosion. Further simulation studies suggest that the proposed model retains its key properties even under moderately large parameter variations. This model provides important insights on how macrophages might play a crucial role in the long term behavior of HIV infection. PMID:23238280

  5. Sugar is an endogenous cue for juvenile-to-adult phase transition in plants

    Yu, Sha; Cao, Li; Zhou, Chuan-Miao; Zhang, Tian-Qi; Lian, Heng; Sun, Yue; Wu, Jianqiang; Huang, Jirong; Wang, Guodong; WANG Jia-wei

    2013-01-01

    eLife digest Like animals, plants go through several stages of development before they reach maturity, and it has long been thought that some of the transitions between these stages are triggered by changes in the nutritional status of the plant. Now, based on experiments with the plant Arabidopsis thaliana, Yu et al. and, independently, Yang et al. have provided fresh insights into the role of sugar in ‘vegetative phase change'—the transition from the juvenile form of a plant to the adult pl...

  6. Partner relationships in the Netherlands: new manifestations of the Second Demographic Transition

    Latten, J.J.; Mulder, C.H.

    2013-01-01

    Partnership formation has rapidly and profoundly changed in theNetherlandssince the 1960s.Several scholars have placed these changes in the context of the Second Demographic Transition. We describe the main trends in the formation and dissolution of partnerships in theNetherlandsbetween the 1960/1970sand 2010 and specifically address the trends from 2000 onwards. To what extent do these trends signal a new stage in the Second Demographic Transition? The data come from the Dutch population reg...

  7. Consumer Debt Delinquency over Life Cycle Stages

    Jing Jian Xiao; Rui Yao

    2011-01-01

    Consumer debt delinquency, as measured by being 60 or more days late in in debt payment, is an indicator of financial ill health. Using six datasets of the 1992-2007 U.S. Surveys of Consumer Finances, this study examines consumer debt delinquency over life cycle stages. Inspired by previous research (Du & Kamakura, 2006), fifteen life cycle stages are defined by household head’s age, marital status, and presence and age of children. Multivariate logistic results show that young couples status...

  8. TWO STAGE FRAMEWORK FOR ALTERED FINGERPRINT MATCHING

    T. R. Anoop; M.G. Mini

    2015-01-01

    Fingerprint alteration is the process of masking one’s identity from personal identification systems especially in boarder control security systems. Failure of matching the altered fingerprint of the criminals against the watch list of fingerprints can help them to break the security system. This fact leads to the need of a method for altered fingerprint matching. This paper presents a two stage method for altered fingerprint matching. In first stage, approximated global ridge orientation fie...

  9. Condensate from a two-stage gasifier

    Bentzen, Jens Dall; Henriksen, Ulrik Birk; Hindsgaul, Claus

    2000-01-01

    Condensate, produced when gas from downdraft biomass gasifier is cooled, contains organic compounds that inhibit nitrifiers. Treatment with activated carbon removes most of the organics and makes the condensate far less inhibitory. The condensate from an optimised two-stage gasifier is so clean...... compounds and the level of inhibition are so low that condensate from the optimised two-stage gasifier can be led to the public sewer....

  10. Researching the life stages of medicines: Introduction

    Geest, van der, S.; Chamberlain, K.

    2011-01-01

    This introduction presents the concept of ‘biography’ or ‘life stages’ of medicines as an ordering principle and analytical tool for the study of medicines as social, commercial and symbolic objects. The first stages, production and marketing, which have been largely neglected by social scientists, receive special attention. Finally, the five contributions to this special half-issue are summarized and placed in the life stages conceptual framework.

  11. Towards Centrifugal Compressor Stages Virtual Testing

    Guidotti, Emanuele

    2014-01-01

    Flow features inside centrifugal compressor stages are very complicated to simulate with numerical tools due to the highly complex geometry and varying gas conditions all across the machine. For this reason, a big effort is currently being made to increase the fidelity of the numerical models during the design and validation phases. Computational Fluid Dynamics (CFD) plays an increasing role in the assessment of the performance prediction of centrifugal compressor stages. Historically, CFD wa...

  12. Staging Lung Cancer: Current Controversies and Strategies

    Riyad Karmy-Jones; Hyland, Robert H.; Lewis, Joseph W; Paul Kvale

    1997-01-01

    A consistent approach to staging is required for the rational management of lung cancer. This paper was prepared at the request of the Standards Committee of the Canadian Thoracic Society, and reviews and discusses the relative merits of the available methods of staging. Whichever methods are chosen by a particular institution, the following points must be stressed. No patient can be considered automatically "unresectable" when chest radiography and/ or computed tomography demonstrate adenopa...

  13. Controversies in Chronic Kidney Disease Staging

    Polkinghorne, Kevan R

    2011-01-01

    In 2002, a new chronic kidney disease staging system was developed by the US National Kidney Foundation. The classification system represented a new conceptual framework for the diagnosis of chronic kidney disease (moving to a schema based on disease severity defined by the glomerular filtration rate). While the introduction of the staging system stimulated significant clinical and research interest in kidney disease, there has been vigorous debate on its merits. This mini-review aims to summ...

  14. Stage IV lung cancer: Is cure possible?

    Ravi Thippeswamy; Vanita Noronha; Vamshi Krishna; Amit Joshi; Munita Meenu Bal; Nilendu Purandare; Rangarajan, V.; Pramesh, C. S.; Sabita Jiwnani; Kumar Prabhash

    2013-01-01

    Reporting a case, 53 years old male with stage IV Nonsamall cell lung cancer in view of cytologically proven malignant pleural effusion. Usually the management of stage IV lung cancer is with palliative intent where the patient receives palliative chemotherapy along with palliative radiotherapy and surgery if required. Most of the data on curative management of oligometastatic non-small cell lung cancer includes patient with adrenal metastasis and some reports with brain metastasis. There is ...

  15. Radiation Therapy for Early Stage Lung Cancer

    Parashar, Bhupesh; Arora, Shruthi; Wernicke, A. Gabriella

    2013-01-01

    Radiation therapy for early stage lung cancer is a promising modality. It has been traditionally used in patients not considered candidates for standard surgical resection. However, its role has been changing rapidly since the introduction of new and advanced technology, especially in tumor tracking, image guidance, and radiation delivery. Stereotactic radiation therapy is one such advancement that has shown excellent local control rates and promising survival in early stage lung cancer. In a...

  16. ESTIMATION OF AGE TRANSITION PROBABILITIES.

    ZINTER, JUDITH R.

    THIS NOTE DESCRIBES THE PROCEDURES USED IN DETERMINING DYNAMOD II AGE TRANSITION MATRICES. A SEPARATE MATRIX FOR EACH SEX-RACE GROUP IS DEVELOPED. THESE MATRICES WILL BE USED AS AN AID IN ESTIMATING THE TRANSITION PROBABILITIES IN THE LARGER DYNAMOD II MATRIX RELATING AGE TO OCCUPATIONAL CATEGORIES. THREE STEPS WERE USED IN THE PROCEDURE--(1)…

  17. Evolutionary transitions in bacterial symbiosis

    Sachs, Joel L.; Skophammer, Ryan G.; Regus, John U.

    2011-01-01

    Diverse bacterial lineages form beneficial infections with eukaryotic hosts. The origins, evolution, and breakdown of these mutualisms represent important evolutionary transitions. To examine these key events, we synthesize data from diverse interactions between bacteria and eukaryote hosts. Five evolutionary transitions are investigated, including the origins of bacterial associations with eukaryotes, the origins and subsequent stable maintenance of bacterial mutualism with hosts, the captur...

  18. Phenomenology of cosmic phase transitions

    The evolution of the cosmic matter from Planck temperature to the atomic combination temperature is considered from a phenomenological point of view. Particular emphasis is devoted to the sequence of cosmic phase transitions. The inflationary era at the temperature of the order of the grand unification energy scale and the quantum chromodynamic confinement transition are dealt with in detail. (author) 131 refs.; 26 figs

  19. Transition management: origin, evolution, critique

    J. Rotmans (Jan); D.A. Loorbach (Derk); R. Kemp (René)

    2007-01-01

    textabstractTransition management has rapidly emerged over the past few years as a new approach to dealing with complex societal problems and governance in the context of these problems. In the Netherland, UK and Belgium, serious efforts have been and are being undertaken to develop transition polic

  20. Process Challenges and Learning-Based Interactions in Stage 2 of Doctoral Education: Implications from Two Applied Social Science Fields

    Baker, Vicki L.; Pifer, Meghan J.; Flemion, Blair

    2013-01-01

    This article reports on an exploratory study that examined the transition to independence in Stage 2 of the doctoral student experience in two applied social science fields. We rely on an interdisciplinary framework that integrates developmental networks and sociocultural perspectives of learning to better understand the connection between the…