WorldWideScience

Sample records for 15-year single center

  1. A Look into the National Drought Mitigation Center: Providing 15 Years of Drought Services (Invited)

    Svoboda, M. D.; Hayes, M. J.; Knutson, C. L.; Wardlow, B. D.

    2009-12-01

    The National Drought Mitigation Center (NDMC) was formed in 1995 at the University of Nebraska-Lincoln. Over the past 15 years, the NDMC has made it a priority to work with various local, state, tribal and federal entities to provide a suite of drought/climate services, with a goal of bringing research to fruition through applications and operations. Through our research and outreach projects, the NDMC has worked to reduce risk to drought by developing several mitigation strategies, monitoring and decision making tools and other services aimed at enhancing our nation’s capacity to cope with drought. Two of the earliest NDMC activities were the creation of a website and assessing drought conditions around the United States. An electronic drought clearinghouse was built in 1995 at drought.unl.edu. The site was designed, and still concentrates, on the concepts of drought monitoring, planning, and mitigation and also serves as a repository of information from around the world. The NDMC’s electronic quarterly newsletter, DroughtScape, disseminates information about all things drought to people across the country. In addition, the NDMC has developed and is home to websites for the U.S. Drought Monitor (USDM), Drought Impact Reporter (DIR), and the Vegetation Drought Response Index (VegDRI). In an effort to inform decision makers, the NDMC continually pursues ways to raise the awareness and visibility of drought as one of the most costly hazards we face. This began in the mid-1990s with the creation of a state-based drought impact assessment map that would help lead to the formation of the USDM in 1999 and the DIR in 2005. The NDMC plays a key role in producing the weekly USDM and the monthly North American Drought Monitor (NADM). The USDM was created out of collaborations between the NDMC, United States Department of Agriculture (USDA) and National Oceanic and Atmospheric Administration (NOAA) and has quickly become one of the most widely used products in assessing

  2. Malaysia family-planning centers strive to maintain gains won in 15-year period.

    Roemer, R

    1968-09-12

    Family planning in Malaysia is discussed. Family planning began in Malaysia about 15 years ago through the efforts of voluntary family Planning Associations in the various Malay states. In 1966 the Malaysian Parliament passed the National Family Planning Act setting up the National FAmily Planning Board to formulate policies and methods for the promotion and spread of family planning knowledge and practice on the grounds of health of mothers and children and welfare of the family. In 1967, the board set a target of 40,000 new acceptors of family planning and 90% of the target was reached. This represents 3% of the child-bearing married women aged 15-49. The target for 1968 of 65,000 new acceptors is being achieved. A survey of acceptors is to be carried out from December 1968 to April 1969 to ascertain how many women who accepted family planning continue to practice it. Malaysia's crude birth rate declined from 46.2 in 1957 to 37.3 in 1966 before the government program was instituted. Abortion attempts have been frequent. The main method of contraception used is oral contraceptives. According to a 1957 survey, 31% of the married women in the metropolitan areas and 2% of rural women were using contraception. Presently, in Malaysia there is a need to: 1) train personnel to provide services, 2) inform and motivate families to accept family planning, 3) continue a broad educational program, 4) reform Malaysia's antiquated abortion law, and 5) integrate family planning services more fully into the general health services of the country. PMID:12229348

  3. Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center

    Ambrósio, P; Lermann, R; Cordeiro, A.; Borges, A.; Nogueira, I.; Serrano, F.

    2010-01-01

    This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal–maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were in remission 6 months prior to pregnancy (93%) and the most frequently affect...

  4. Radiation Therapy Improves Survival Outcome in Pancreatic Adenocarcinoma: Comparison of a 15-Year Institutional Experience at the University of Nebraska Medical Center with SEER Data

    Objectives. We examined the role of radiation therapy (RT) in pancreatic adenocarcinoma (PA) treatment through a 15-year retrospective analysis of patients treated at University of Nebraska Medical Center (UNMC) as well as those from the SEER database. Methods. A total of 561 patients diagnosed with PA at UNMC between 1995 and 2011 and 60,587 patients diagnosed between 1995 and 2009 from the SEER were included. Examined prognostic factors for overall survival (OS) were age, gender, race, stage, year of diagnosis, and treatment with surgery, chemotherapy (CT), or RT. Time to death was plotted by Kaplan-Meier method. A Cox proportional hazards model was used to evaluate prognostic factors for OS. Results. The median OS was 7.3 and 5 months for patients from UNMC and the SEER database, respectively. A Cox model of patients from UNMC showed that RT was associated with improved OS (HR 0.77,(Ρ =0.018) after adjusting for factors including age, race, gender, stage, year of diagnosis, having surgery, or having CT. Cox analysis of patients from the SEER showed similar results (HR 0.65, (Ρ0.0001). Conclusions. RT confers an independent survival advantage in patients being treated for PA which is apparent both at UNMC and through SEER data.

  5. Hepatoblastoma: Experience from a single center

    Singh, T.; C T Satheesh; Appaji, L.; Aruna Kumari BS; M Padma; Kumar, M V; Mukherjee, G.

    2010-01-01

    Background: The cornerstones of successful treatment of hepatoblastoma (HB) include preoperative chemotherapy followed by complete anatomical resection of tumor, followed by chemotherapy. Advances in chemotherapy in the last 2 decades have been associated with a higher rate of tumor response and possibly a greater potential for resectability. Aims: We analyzed our single center experience with neoadjuvant chemotherapy (NACT) and surgery in HBs. Settings and Design: Our study included all ch...

  6. Neonatal Duodenal Obstruction: A 15-Year Experience

    Kamal Nain Rattan

    2016-04-01

    Full Text Available Background: Congenital duodenal obstruction is one of the commonest causes of neonatal intestinal obstruction. We are presenting our 15-year experience by analyzing clinical spectrum and outcome in neonates with duodenal obstruction admitted at our center. Material and Methods: The hospital records of all neonates admitted with duodenal obstruction from June 2000 to June 2015 were reviewed. The patient records were analyzed for antenatal diagnosis, age, sex, clinical presentation, diagnosis, associated anomalies, surgical procedures performed; postoperative morbidity and mortality. We excluded from our study malrotation of gut associated with congenital diaphragmatic hernia and abdominal wall defects. Results: A total of 81 patients were admitted, out of which 56 were males and 25 were females. Polyhydramnios was detected in 24 (30% pregnancies. Average birth weight was 2.1±1.0Kg and average gestational age was 38 (SD±1 weeks with 17 (21% preterm neonates. Presenting features were vomiting in 81(100% which was bilious in 81% and non bilious in 19%, epigastric fullness in 56 (69% and dehydration in 18 (22% and failure to thrive in 16 (19%. Most common cause of obstruction was duodenal atresia in 38 (46.9%, followed by malrotation of gut in 33 (40.7%, and annular pancreas in 4 cases. Depending upon site of location, infra-ampullary obstruction was the most common in 64 (79%, supra-ampullary in 9 (7.4% and ampullary 8 neonates. Both duodenal atresia and malrotation of gut was present in 4 cases. X-ray abdomen was most commonly used investigation to confirm the diagnosis. All cases were managed surgically by open laparotomy. Eleven (13.5% patients died due to sepsis and associated congenital anomalies. Conclusion: Congenital duodenal obstruction most commonly presents in early neonatal period with features of upper GIT obstruction like vomiting and epigastrium fullness as in our series. Early antenatal diagnosis and surgical interventions hold the

  7. The EPA/NIEHS Children’s Environmental Health And Disease Prevention Research Centers: More Than 15 Years of Innovative Research on Important Challenges in Children’s Environmental Health

    Background: The U.S. Environmental Protection Agency (EPA) and the National Institute of Environmental Health Sciences (NIEHS) have jointly supported the Children's Environmental Health and Disease Prevention Research Centers (“Children’s Centers”) program since...

  8. Hepatoblastoma: Experience from a single center

    T Singh

    2010-01-01

    Full Text Available Background: The cornerstones of successful treatment of hepatoblastoma (HB include preoperative chemotherapy followed by complete anatomical resection of tumor, followed by chemotherapy. Advances in chemotherapy in the last 2 decades have been associated with a higher rate of tumor response and possibly a greater potential for resectability. Aims: We analyzed our single center experience with neoadjuvant chemotherapy (NACT and surgery in HBs. Settings and Design: Our study included all children with HBs who received NACT and underwent surgical excision from January 1997 to July 2004. Materials and Methods: Patient characteristics, clinical features, clinical course, treatment modalities, and long-term outcome were analyzed. Results: There were 9 boys and 3 girls, aged 5-60 months (median age at tumor diagnosis was 24 months. All received NACT containing cisplatin and doxorubicin. Of the 12 children, 9 underwent hepatectomy and among them, 4 patients each had right and left hepatectomy and 1 patient underwent right extended hepatectomy. After surgery, all patients completed rest of the chemotherapy course (total 6 cycles. R0 resection was carried out in all the 9 cases with no life-threatening complications. Conclusions: Our experience of the 9 cases, although less in number, reaffirms the advantages of NACT followed by surgery. The prognosis for patients with resectable tumors is fairly good in combination with chemotherapy.

  9. Single Center Experience of Acute Disseminated Encephalomyelitis

    J Gordon Millichap

    2013-01-01

    Investigators at Department of Pediatrics, Neurology Division, Adana Medical Research Center; and Division of Child Neurology, Ankara, Turkey, retrospectively evaluated 15 children with acute disseminated encephalomyelitis (ADEM) in children from the center in Adana.

  10. Adolescent death: a 15-year retrospective review.

    Batalis, Nick I; Collins, Kim A

    2005-11-01

    Adolescents comprise an eclectic mix of people vitally important to society yet long-term comprehensive studies on the circumstances of their deaths are lacking in the pediatric forensic literature. The authors reviewed all forensic cases referred to the Medical University of South Carolina Forensic Pathology section over the fifteen years between January 1989 and December 2003. In accordance with the World Health Organization (WHO) definition of adolescents, only decedents 10-19 years of age were included. The authors examined the cause and manner of death, age, gender, and race of the victims in all cases. The toxicology results, perpetrator, death scenario and location, and victim traits were analyzed when available. For all adolescents, the most common manner of death was accident followed by homicide, suicide, natural, and undetermined. Within the adolescent population two distinct groups, 10-14 years old and 15-19 years old, were identified. Though both groups were similar in that they experienced a high number of accidental deaths, decedents of older age group suffered a higher percentage of violent deaths while decedents of the younger group were more likely to die of natural causes. Many of the accidental deaths in this review were preventable, including deaths due to motor vehicle collisions and drowning. In deaths due to homicide, the perpetrator was often known to the victim, whether as an acquaintance or family member. Toxicology testing was often positive in decedents of the older age group, while only rarely positive in decedents of the younger age group. With a solid understanding of the circumstances, it may be possible to predict, and hopefully prevent, future cases of adolescent death. The authors present their findings in this 15-year retrospective study to better aid forensic pathologists, death investigators, law enforcement, and epidemiologists. PMID:16382843

  11. Photophysics of single silicon vacancy centers in diamond: implications for single photon emission

    Neu, Elke; Becher, Christoph

    2012-01-01

    Single silicon vacancy (SiV) color centers in diamond have recently shown the ability for high brightness, narrow bandwidth, room temperature single photon emission. This work develops a model describing the three level population dynamics of single SiV centers in diamond nanocrystals on iridium surfaces including an intensity dependent de-shelving process. Furthermore, we investigate the brightness and photostability of single centers and find maximum single photon rates of 6.2 Mcps under continuous excitation. We investigate the collection efficiency of the fluorescence and estimate quantum efficiencies of the SiV centers.

  12. Pregnancy during Hemodialysis: A Single Center Experience

    Bahadi Abdelali

    2010-01-01

    Full Text Available Successful pregnancy outcome is an uncommon occurrence in women requiring chronic dialysis treatment. We reviewed the course and outcome of 9 pregnancies occurred in women on chronic hemodialysis in our center from 1999-2007; 5 of them ended with delivery of alive newborns, 2 with fetal deaths in-utero, and 2 with abortions. The average age of patients was 34 years. The etiology of the original kidney disease was unknown in 44.4% of the cases, and only 22.2% of the patients maintained diuresis. Dialysis started in 8 cases before the diagnosis of pregnancy. The average gestational age at diagnosis was 14 weeks. We modified the prescription of dialysis in 4 patients by increasing the frequency of the dialysis sessions to 6 per week and in 3 by increasing the duration of each session to 6 hours. Anemia was present in all the cases; 3 patients received erythropoietin and 4 patients required transfusion. The pregnancy was com-plicated in 44% of the cases by a polyhydramnios. The average time at delivery was 33 weeks and it was achieved in 80% of pregnancies through vaginal route. The average weight of newborns was to 2380 g. We conclude that pregnancy in women on hemodialysis is possible. The success of pregnancy may be influenced by the residual diuresis and early diagnosis to improve the quality of dialysis by increasing the dialysis dose.

  13. Nanoscale fluorescence lifetime imaging with a single diamond NV center

    Beams, Ryan; Johnson, Timothy W; Oh, Sang-Hyun; Novotny, Lukas; Vamivakas, Nick

    2013-01-01

    Solid-state quantum emitters, such as artificially engineered quantum dots or naturally occurring defects in solids, are being investigated for applications ranging from quantum information science and optoelectronics to biomedical imaging. Recently, these same systems have also been studied from the perspective of nanoscale metrology. In this letter we study the near-field optical properties of a diamond nanocrystal hosting a single nitrogen vacancy center. We find that the nitrogen vacancy center is a sensitive probe of the surrounding electromagnetic mode structure. We exploit this sensitivity to demonstrate nanoscale fluorescence lifetime imaging microscopy (FLIM) with a single nitrogen vacancy center by imaging the local density of states of an optical antenna.

  14. Single-color centers implanted in diamond nanostructures

    Hausmann, Birgit J M; Babinec, Thomas M; Choy, Jennifer T; Bulu, Irfan; Loncar, Marko [School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 (United States); Hodges, Jonathan S; Hong, Sungkun; Yacoby, Amir; Lukin, Mikhail D, E-mail: loncar@seas.harvard.edu [Department of Physics, Harvard University, Cambridge, MA 02138 (United States)

    2011-04-15

    The development of material-processing techniques that can be used to generate optical diamond nanostructures containing a single-color center is an important problem in quantum science and technology. In this work, we present the combination of ion implantation and top-down diamond nanofabrication in two scenarios: diamond nanopillars and diamond nanowires. The first device consists of a 'shallow' implant ({approx}20 nm) to generate nitrogen-vacancy (NV) color centers near the top surface of the diamond crystal prior to device fabrication. Individual NV centers are then mechanically isolated by etching a regular array of nanopillars in the diamond surface. Photon anti-bunching measurements indicate that a high yield (>10%) of the devices contain a single NV center. The second device demonstrates 'deep' ({approx}1 {mu}m) implantation of individual NV centers into diamond nanowires as a post-processing step. The high single-photon flux of the nanowire geometry, combined with the low background fluorescence of the ultrapure diamond, allowed us to observe sustained photon anti-bunching even at high pump powers.

  15. Plasmonic resonators for enhanced diamond NV- center single photon sources

    Bulu, Irfan; Hausmann, Birgit; Choy, Jennifer T; Loncar, Marko

    2011-01-01

    We propose a novel source of non-classical light consisting of plasmonic aperture with single-crystal diamond containing a single Nitrogen-Vacancy (NV) color center. Theoretical calculations of optimal structures show that these devices can simultaneously enhance optical pumping by a factor of 7, spontaneous emission rates by Fp ~ 50 (Purcell factor), and offer collection efficiencies up to 40%. These excitation and collection enhancements occur over a broad range of wavelengths (~30nm), and are independently tunable with device geometry, across the excitation (~530nm) and emission (~600-800nm) spectrum of the NV center. Implementing this system with top-down techniques in bulk diamond crystals will provide a scalable architecture for a myriad of diamond NV center applications.

  16. Coupling of single NV Center to adiabatically tapered optical single mode fiber

    Vorobyov, Vadim V; Bolshedvorskii, Stepan V; Javadzade, Javid; Lebedev, Nikolay; Smolyaninov, Andrey N; Sorokin, Vadim N; Akimov, Alexey V

    2016-01-01

    We demonstrated a simple and reliable technique of coupling diamond nanocrystal containing NV center to tapered optical fiber. We carefully studied fluorescence of the fiber itself and were able to suppress it to the level lower than single photon emission from the NV center. Single photon statistics was demonstrated at the fiber end as well as up to 3 times improvement in collection efficiency with respect to our confocal microscope

  17. Operational experience at radioactive waste treatment plant, after 15 years

    Available in abstract form only. Full text of publication follows: The experience of the radioactive waste treatment plant (PTDR) in Chile, which centralizes all activities related to pre-disposal activities in the radioactive waste management, in the country is presented. It is the solely waste treatment plant in the country, where radioactive waste are received from all nuclear and radioactive waste generators facilities located in the country. Radioactive waste in Chile proceeds from radioisotope application at industrial, health, universities research, and from two nuclear research centers. Lately, there have been included the radioactive wastes discovered in metal recycling facilities, which sometimes make big amounts. Radioactive Waste Treatment Plant was planned in 1990; adoption of decision and started operation in 1992. At that time, a facility to store waste packages as conditioned waste in cementitious matrices in standardized 200 l drums was built (43 m3 total capacity) for a storage period estimated in 15 years. The methodology and procedures developed has been transferred to Latin American and El Caribe professionals, through demonstration training courses held in this Waste Treatment Plant which recognized as Demonstration facilities to prepare people in the processing of radioactive waste from nuclear applications, previous to disposal. These procedures were the first one developed following international recommendations and complying requirements to immobilize the radioactive material to avoid the external intrusion of thirds, and requirements of dose radiation according to transport regulations for radioactive material. (authors)

  18. Liver transplantation in Greek children: 15 years experience

    Dimitrios Takoudas

    2010-09-01

    Full Text Available Liver transplantation (LT is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclo­sporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV1,2, 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation. The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers.

  19. Nanoscale fluorescence lifetime imaging with a single diamond NV center

    Beams, Ryan; Smith, Dallas; Johnson, Timothy W.; Oh, Sang-Hyun; Novotny, Lukas; Vamivakas, Nick

    2013-01-01

    Solid-state quantum emitters, such as artificially engineered quantum dots or naturally occurring defects in solids, are being investigated for applications ranging from quantum information science and optoelectronics to biomedical imaging. Recently, these same systems have also been studied from the perspective of nanoscale metrology. In this letter we study the near-field optical properties of a diamond nanocrystal hosting a single nitrogen vacancy center. We find that the nitrogen vacancy ...

  20. Pulsed magnetic resonance on single defect centers in diamond

    Popa, Iulian

    2006-01-01

    In the present work, the spin properties of single Nitrogen-Vacancy (NV) defect centers in diamond are investigated, in perspective to their application to quantum computing. One of the actual approaches to quantum computing is based on spins, and, therefore, their behavior and properties related to manipulation and readout are very important. Using conventional NMR, an ensemble of spins can be used as a qubit implementation. However, the method has limitations in regards to the number o...

  1. Thrombolytics in VAD management — A single-center experience

    Nair, N.; Schmitt, A A; E.M. Rau; Anders, S.; Sandler, D.; T.B. Icenogle

    2016-01-01

    Background: With continued increase in the use of mechanical circulatory support, the incidence of device thrombus remains a challenge. This study is a retrospective analysis of data at a single center to assess the safety and efficacy of thrombolytic use in durable mechanical assist devices. Methods: Data was analyzed retrospectively from 154 patients who underwent left ventricular assist device (LVAD) implantation from 1/1/2005 to 6/30/2014. The HMII device was implanted in 131 patients ...

  2. Impact of aprotinin and renal function on mortality: a retrospective single center analysis

    Von Visger Jon

    2011-08-01

    Full Text Available Abstract Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing bleeding. Aprotinin was removed from the market by the U.S. Food and Drug Administration after a large prospective, randomized clinical trial documented an increased mortality risk associated with the drug. Further debate arose when a meta-analysis of 211 randomized controlled trials showed no risk of renal failure or death associated with aprotinin. However, only patients with normal kidney function have been studied. Methods In this study, we look at a single center clinical trial using patients with varying degrees of baseline kidney function to answer the question: Does aprotinin increase odds of death given varying levels of preoperative kidney dysfunction? Results Based on our model, aprotinin use was associated with a 3.8-fold increase in odds of death one year later compared to no aprotinin use with p-value = 0.0018, regardless of level of preoperative kidney dysfunction after adjusting for other perioperative variables. Conclusions Lessons learned from our experience using aprotinin in the perioperative setting as an antifibrinolytic during open cardiac surgery should guide us in testing future antifibrinolytic drugs for not only efficacy of preventing bleeding, but for overall safety to the whole organism using long-term clinical outcome studies, including those with varying degree of baseline kidney function.

  3. Epidemiologia de 118 casos de esclerose múltipla com seguimento de 15 anos no centro de referência do Hospital da Restauração de Pernambuco Epidemiology of 118 cases of multiple sclerosis after 15 years of follow-up on the reference center of Hospital da Restauração, Recife, Pernambuco, Brazil

    Maria Lúcia Brito Ferreira

    2004-12-01

    : according to a descriptive, prospective, longitudinal, prevalence study, we analyzed data of 118 patients, who attended at the Reference Center for Attention to Patients with Demielinizating Diseases of Hospital da Restauração (CRAPPDD-HR - Recife - Pernambuco, Brazil, from January 1987 to March 2002, to have MS diagnosed according to Poser criteria. RESULTS: The patients were followed up by 1 to 15 years. Ninety five (80.5% patients were in treatment with immune-modulators. The prevalence was 1,36:100000 habitants. We have identified: predominance of mulattoes (110,93.2%, 82 (82.2% cases clinically defined, 15 (12.7% cases laboratorial defined and 6 (5.1% cases clinically probable; a number of maximum bouts equal to 46; more frequent mild EDSS for patients with 1 to 10 years of MS of remittent-recurrent (RR form. Gender rate of 83 cases of RR form was equivalent to the general one, however on RR with secondary progressive form form, the rate was 2.5 times greater for females than for males, and on primary progressive form, 5.5 times greater for males. CONCLUSION: Although some results of this research had been similar to that of eight studies used as standards for comparison, the differences will require new approaches.

  4. Complications 15 years after breast augmentation with polyacrylamide

    Ghasemi, Habib; Damsgaard, Tine Engberg; Stolle, Lars B.; Christensen, Bekka Anina O.

    2015-01-01

    Polyacrylamide hydrogel (PAAG) has been used as an injectable, permanent filler for soft-tissue augmentation for more than two decades. Several complications have been reported worldwide. In this case report, we present a woman with long-term complications 15 years after bilateral breast augmenta......Polyacrylamide hydrogel (PAAG) has been used as an injectable, permanent filler for soft-tissue augmentation for more than two decades. Several complications have been reported worldwide. In this case report, we present a woman with long-term complications 15 years after bilateral breast...... augmentation with PAAG injections....

  5. Complications 15 years after breast augmentation with polyacrylamide

    Ghasemi, Habib; Damsgaard, Tine Engberg; Stolle, Lars B; Christensen, Bekka Anina O.

    2015-01-01

    Polyacrylamide hydrogel (PAAG) has been used as an injectable, permanent filler for soft-tissue augmentation for more than two decades. Several complications have been reported worldwide. In this case report, we present a woman with long-term complications 15 years after bilateral breast augmentation with PAAG injections.

  6. Complications 15 years after breast augmentation with polyacrylamide

    Ghasemi, Habib; Damsgaard, Tine Engberg; Stolle, Lars Bjørn;

    2015-01-01

    Polyacrylamide hydrogel (PAAG) has been used as an injectable, permanent filler for soft-tissue augmentation for more than two decades. Several complications have been reported worldwide. In this case report, we present a woman with long-term complications 15 years after bilateral breast...... augmentation with PAAG injections....

  7. Developing mathematical culture of 7-15-year old students

    Tichá, Marie

    Torino: Ghisetti e Corvi, 2001, s. 78-80. [CIEAEM 53. Verbania (IT), 21.07.2001-27.07.2001] Institutional research plan: CEZ:AV0Z1019905 Keywords : mathematical education of 7-15- year old students%developmed o culture Subject RIV: AM - Education

  8. Single-center experience in double kidney transplantation.

    Fontana, I; Magoni Rossi, A; Gasloli, G; Santori, G; Giannone, A; Bertocchi, M; Piaggio, F; Bocci, E; Valente, Umberto

    2010-05-01

    Use of organs from marginal donors for transplantation is a current strategy to expand the organ donor pool. Its efficacy is universally accepted among data from multicenter studies. Herein, we have reviewed outcomes of double kidney transplantation (DKT) over an 9-year experience in our center. The aim of this study was to evaluate possible important differences between a monocenter versus multicenter studies. Between 1999 and 2008, we performed 59 DKT. Recipient mean age was 63 +/- 5 years. Mean HLA-A, -B, and -DR mismatches were 3.69 +/- 0.922. Donor mean age was 69 +/- 7 years and mean creatinine clearance was 69.8 +/- 30.8 mL/min. Proteinuria was detected in three donors (5%). Mean cold ischemia and warm ischemia times were 1130 +/- 216 and 48 +/- 11 minutes, respectively. The right and left kidney scores were 4.18 +/- 2 and 4.21 +/- 2, respectively. Thirty patients (51%) displayed good postoperative renal function; 22 (37%), acute tubular necrosis with postoperative dialysis; 3 (5%), acute rejection episodes; 4 (7%), single-graft transplantectomy due to vascular thrombosis; 1 (2%), a retransplantation; 5 (8%), a lymphocele; 3 (5%) vescicoureteral reflux or stenosis requiring surgical correction. Cytomegalovirus infection was detected in five patients (8%). In three patients (5%) displayed de novo neoplasia. Three patients showed chronic rejection (5%), whereas we observed a cyclosporine-related toxicity in 7 (12%). Nine patients (15%) developed iatrogenic diabetes. Patient and graft survivals after 3 years from DKT were 93% and 86.3%, respectively. In this study, we applied successfully a widespread score to allocate organs to single kidney transplantation or DKT. In our experience, the score is suitable for the organ allocation but it may be overprotective, excluding potentially suitable organs for a single transplantation. PMID:20534235

  9. ASTER system operating achievement for 15 years on orbit

    Inada, Hitomi; Ito, Yoshiyuki; Kikuchi, Masakuni; Sakuma, Fumihiro; Tatsumi, Kenji; Akagi, Shigeki; Ono, Hidehiko

    2015-10-01

    ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) System is operating more than 15 years since launched on board of NASA's Terra spacecraft in December 1999. ASTER System is composed of 3 radiometers (VNIR (Visible and Near Infrared Radiometer), SWIR (Short-Wave Infrared Radiometer), and TIR (Thermal Infrared Radiometer)), CSP (Common Signal Processor) and MSP (Master Power Supply). This paper describes the ASTER System operating history and the achievement of ASTER System long term operation since the initial checkout operation, the normal operation, and the continuous operation. Through the 15 years operation, ASTER system had totally checked the all subsystems (MPS, VNIR, TIR, SWIR, and CSP) health and safety check using telemetry data trend evaluation, and executed the necessary action. The watch items are monitored as the life control items. The pointing mechanics for VNIR, SWIR and TIR, and the cooler for SWIR and TIR are all operating with any problem for over 15 years. In 2003, ASTER was successfully operated for the lunar calibration. As the future plan, ASTER team is proposing the 2nd lunar calibration before the end of mission.

  10. Center for Applications of Single-Walled Carbon Nanotubes

    Resasco, Daniel E

    2008-02-21

    This report describes the activities conducted under a Congressional Direction project whose goal was to develop applications for Single-walled carbon nanotubes, under the Carbon Nanotube Technology Center (CANTEC), a multi-investigator program that capitalizes on OU’s advantageous position of having available high quality carbon nanotubes. During the first phase of CANTEC, 11 faculty members and their students from the College of Engineering developed applications for carbon nanotubes by applying their expertise in a number of areas: Catalysis, Reaction Engineering, Nanotube synthesis, Surfactants, Colloid Chemistry, Polymer Chemistry, Spectroscopy, Tissue Engineering, Biosensors, Biochemical Engineering, Cell Biology, Thermal Transport, Composite Materials, Protein synthesis and purification, Molecular Modeling, Computational Simulations. In particular, during this phase, the different research groups involved in CANTEC made advances in the tailoring of Single-Walled Carbon Nanotubes (SWNT) of controlled diameter and chirality by Modifying Reaction Conditions and the Nature of the catalyst; developed kinetic models that quantitatively describe the SWNT growth, created vertically oriented forests of SWNT by varying the density of metal nanoparticles catalyst particles, and developed novel nanostructured SWNT towers that exhibit superhydrophobic behavior. They also developed molecular simulations of the growth of Metal Nanoparticles on the surface of SWNT, which may have applications in the field of fuell cells. In the area of biomedical applications, CANTEC researchers fabricated SWNT Biosensors by a novel electrostatic layer-by-layer (LBL) deposition method, which may have an impact in the control of diabetes. They also functionalized SWNT with proteins that retained the protein’s biological activity and also retained the near-infrared light absorbance, which finds applications in the treatment of cancer.

  11. Lessons Learned After 15 Years of Circumferential Bodylift Surgery.

    Small, Kevin H; Constantine, Ryan; Eaves, Felmont F; Kenkel, Jeffrey M

    2016-06-01

    Circumferential bodylift is a powerful procedure for achieving dramatic and natural body contouring changes in the massive weight loss patient. The care of these patients has raised our awareness of several important issues including safety, nutritional status, skin quality, recurrent laxity, surgical steps, and postoperative scars. Integration of this knowledge with various technical modifications over the last 15 years has improved our care for this cohort. We have not only seen a rise in the number of surgeries performed, but also the development of principles, techniques, and details that the authors feel necessary to share to achieve improved contour and more predictable outcomes. LEVEL OF EVIDENCE 4: Therapeutic. PMID:26821642

  12. Bilateral Ota nevus in a 15 years old patient

    Savaş Öztürk

    2013-12-01

    Full Text Available Nevus of Ota is a dermal melanocytosis, clinically localizedon skin that is innervated by the first and secondbranches of the trigeminal nerve. It occurs almost entirelyin Asian people. The clinical manifestations are usuallyunilateral; only 5% of cases are bilateral. In this article,due to rarity of the case, a 15-year-old patient, who was diagnosedwith bilateral ota nevus, without having any dermatologicalcomplaints other than cosmetic appearenceand stains in her eyes and around was presented.Key words: Bilateral ota nevus, child, melanocytosis

  13. ASTER 15 years challenging trail on-orbit operation

    Kikuchi, Masakuni; Sakuma, Fumihiro; Tatsumi, Kenji; Inada, Hitomi; Itou, Yoshiyuki; Akagi, Shigeki; Ono, Hidehiko

    2015-10-01

    The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is a high-resolution optical sensor system that can observe in a wide region from the visible and near-infrared, the short wavelength infrared to the thermal infrared with 14 spectral bands on board of NASA's Terra spacecraft for Earth Observing System (EOS) "A mission to planet earth." ASTER achieved 5 years mission success on orbit operation normally which is the specified target after launched on December, 1999. And after through 10 years continuous orbit operation, ASTER has still operating the long life observation of extra success to be 15 years in total on December, 2014. As for ASTER instrument that is composed of 3 radiometers; the Visible and Near Infrared Radiometer (VNIR) with 3 bands, the Short Wavelength Infrared Radiometer (SWIR) with 6 bands, the Thermal Infrared Radiometer (TIR) with 5 bands, overall ASTER long life data taken by 15 years onboard operation has been reviewed from the point of view of the health and safety check by Telemetry (TLM) data trend, the function and performance evaluation by observation data trend, the onboard calibration and verification by periodic Calibration(CAL) data trend. As a result, the radiometric degradation of VNIR and TIR and the temperature rise of SWIR detector were identified as significant challenges. The countermeasure plan towards the end of mission was clarified and also the novel lessons learned was verified.

  14. Mycophenolate mofetil in pediatric renal transplantation: A single center experience.

    Raheem, Omer A

    2011-05-01

    Raheem OA, Kamel MH, Daly PJ, Mohan P, Little DM, Awan A, Hickey DP. Mycophenolate mofetil in pediatric renal transplantation: A single center experience. Pediatr Transplantation 2011: 15:240-244. © 2009 John Wiley & Sons A\\/S. Abstract:  We assessed our long-term experience with regards to the safety and efficacy of MMF in our pediatric renal transplant population and compared it retrospectively to our previous non-MMF immunosuppressive regimen. Forty-seven pediatric renal transplants received MMF as part of their immunosuppressive protocol in the period from January 1997 till October 2006 (MMF group). A previously reported non-MMF group of 59 pediatric renal transplants was included for comparative analysis (non-MMF group). The MMF group comprised 29 boys and 18 girls, whereas the non-MMF group comprised 34 boys and 25 girls. Mean age was 11.7 and 12 yr in the MMF and non-MMF groups, respectively. The incidence of acute rejection episodes was 11 (23.4%) and 14 (24%) in the MMF and non-MMF group, respectively. Two (3.3%) grafts were lost in the non-MMF group compared with one (2.1%) in the MMF group. Twenty-one (44.68%) patients in the MMF group developed post-transplant infections compared with 12 (20.33%) in the non-MMF group (p < 0.0001). In conclusion, the use of MMF in pediatric renal transplantation was not associated with a lower rejection rate or immunological graft loss. It did, however, result in a significantly higher rate of viral infections.

  15. Atomic-scale positioning of single spins via multiple nitrogen-vacancy centers

    Ma, Wen-Long; Li, Shu-Shen; Cao, Geng-Yu; Liu, Ren-Bao

    2015-01-01

    We present a scheme of positioning a single electron spin with sub-nanometer resolution through multiple nitrogen-vacancy centers in diamond. With unwanted noise suppressed by dynamical decoupling, the spin coherence of each center develops characteristic oscillations due to a single electron spin located $4{\\sim20}$ nm away from the centers. We can extract the position information from the characteristic electron spin-coherence oscillations of each center. This scheme is useful for high-reso...

  16. Atrial Fibrillation Following Surgical Management of Ischemic Heart Disease; One Year, Single Center, Single Surgeon Results

    Ahmet Barış Durukan

    2012-08-01

    Full Text Available Introduction: Postoperative atrial fibrillation is the most common arrhythmia following bypasssurgery with significant morbidity, mortality and increased healthcare costs. The aim of this studyis to determine the incidence and timing of atrial fibrillation, identify the risk factors coveringpreoperative and intraoperative periods, evaluate rate of return to sinus rhythm by disharge, andexplore the impact on postoperative outcomes in a large group of patients operated in a singlecenter by a single surgeon.Patients and Methods: Between January 2011 and January 2012, 418 patients on preoperativesinus rhythm were operated for ischemic heart disease and associated complications (left ventricleaneurysm repair and ischemic mitral insufficiency in a single center, by a single surgeon.The preoperative, intraoperative and postoperative variables were studied.Results: The mean age of the patients were 61.92 ± 10.05, and 77.5% were male. Atrial fibrillationdeveloped in 68 (16.3% patients. The incidence peaked at second day. Patients with atrialfibrillation were older (p< 0.001. Gender, preoperative comorbidities, ejection fraction, left atrialdiameter, preoperative beta-blocker use, leukocyte count, type of operation and intraoperativevariables did not affect its occurence. Intensive care unit and hospital length of stay were longer(p< 0.05. 95.5% (n= 65 of patients were in normal sinus rhythm at discharge.Conclusion: Postoperative atrial fibrillation is a popular subject with unknowns and controversialresults which may lead to wrong interpretations. We believe that every center has its own risk factors related with the population of that region. Discussion will last, but simple precautions and close monitoring will help to minimizeadverse outcomes.

  17. Skin test reactivity among Danish children measured 15 years apart

    Thomsen, SF; Ulrik, Charlotte Suppli; Porsbjerg, C;

    2006-01-01

    test (SPT) positivity in Danish children has changed from 1986 to 2001. METHODS: Serial cross-sectional studies of two different random population samples of children aged 7 to 17 years of age, living in urban Copenhagen, Denmark, were performed 15 years apart. The first cohort was investigated in 1986...... (n = 527) and the second in 2001 (n = 480). Skin test reactivity to nine common aeroallergens was measured at both occasions. RESULTS: The prevalence of positive SPT to at least one allergen decreased from 24.1% in 1986 to 18.9% in 2001, (p = 0.05). We found a declining prevalence of sensitization...... to most allergens tested, statistically significant; however, only for mugwort and Alternaria iridis. Among subjects, who were sensitized to only one allergen, we found significantly fewer individuals with reactions to D. pteronyssinus and mugwort. CONCLUSIONS: The prevalence of atopic sensitization...

  18. Famitinib in metastatic renal cell carcinoma: a single center study

    ZHANG Wen; ZHOU Ai-ping; QIN Qiong; CHANG Chun-xiao; JIANG Hao-yuan; MA Jian-hui; WANG Jin-wan

    2013-01-01

    Background Famitinib is a novel and potent multitargeting receptor tyrosine kinase inhibitor.The phase I clinical study showed that famitinib was well tolerated and had a broad anti-tumor spectrum.The purpose of this study was to examine the efficacy and safety of famitinib for the treatment of metastatic renal cell carcinoma (mRCC).Methods The data of famitinib in treating patients with mRCC from the single-center phases Ⅰ and Ⅱ clinical trials were analyzed.Famitinib was administered orally at the dose of 13-30 mg once daily until tumor progression,occurrence of intolerable adverse reactions or withdrawal of the informed consent.Results A total of 24 patients with mRCC were treated including 17 patients at a dose of 25 mg once daily,4 patients at a dose of 27 mg and 1 patient each at a dose of 13 mg,20 mg and 30 mg,respectively.Twelve (50.0%) patients achieved partial response (PR) and 9 patients achieved stable disease (SD).Progressive disease was found in 3 (12.5%) patients.The disease control rate was 87.5%.The median follow-up time was 17.6 months; the median progression free survival (PFS) was 10.7 (95% Cl7.0-14.4) months; and the estimated median overall survival (OS) time was 33.0 (95% Cl8.7-57.3) months.The adverse drug reactions mainly included hypertension (54.1%),hand-foot skin reactions (45.8%),diarrhea (33.3%),mucositis (29.2%),neutropenia (45.8%),thrombocytopenia (29.2%),hyperlipidemia (41.7%) and proteinuria (41.7%).The incidence rate of grades 3 and 4 adverse events was low,mainly including hypertension 12.5%,hand-foot skin reactions 4.2%,neutropenia 4.2%,thrombocytopenia 4.2%,hyperlipidemia 4.2% and proteinuria 12.5%.Conclusions Famitinib has significant anti-tumor activity in mRCC.The common adverse reactions are generally manageable.

  19. Interventional Treatment of Pulmonary Valve Stenosis: A Single Center Experience

    Shpend Idrizi

    2015-08-01

    Full Text Available BACKGROUND: Percutaneous pulmonary valvuloplasty is well established treatment of choice in pulmonary valve stenosis. AIM: The aim of our study was to present our experience with the interventional technique, its immediate and mid-term effectiveness as well as its complication rate. MATERIAL AND METHODS: The study included 43 patients, where 33 (74% of them were children between the age of 1 month and 15 years. RESULTS: The procedure was successful in 38 patients or 90%. Mean peak to peak transvalvular gradient was reduced from 91.2 mmHg (55-150 mmHg to 39.1 mmHg (20-80 mmHg. Follow- up of patients was between 2 and 13 years and included echocardiographic evaluation of pulmonary valve gradient, right heart dimensions and function as well as assessment of pulmonary regurgitation. We experienced one major complication pericardial effusion in a 5 months old child that required pericardiocenthesis. Six patients (13.9% required a second intervention. During the follow up period there was significant improvement of right heart function and echocardiography parameters. Mild pulmonary regurgitation was noted in 24 (55% patients, and four (9% patients developed moderate regurgitation, without affecting the function of the right ventricle. CONCLUSIONS: Percutaneous pulmonary valvuloplasty is an effective procedure in treatment of pulmonary stenosis with good short and mid-term results.

  20. Pediatric Heart Transplantation: Report from a Single Center in China

    Fei Li; Jie Cai; Yong-Feng Sun; Jin-Ping Liu; Nian-Guo Dong

    2015-01-01

    Background:Although heart transplantation (HTx) has become a standard therapy for end-stage heart diseases,experience with pediatric HTx is limited in China.In this article,we will try to provide the experience with indications,complications,perioperative management,immunosuppressive therapy,and survival for pediatric HTx based on our clinical work.Methods:This is a retrospective chart review of the pediatric patients undergoing HTx at Department of Cardiovascular Surgery of Union Hospital from September 2008 to December 2014.We summarized the indications,surgical variables,postoperative complications,and survival for these patients.Results:Nineteen pediatric patients presented for HTx at Union Hospital of Tongji Medical College,of whom 10 were male.The age at the time of transplantation ranged from 3 months to 18 years (median 15 years).Patient weight ranged from 5.2 kg to 57.0 kg (median 38.0 kg).Pretransplant diagnosis included cardiomyopathy (14 cases),complex congenital heart disease (3 cases),and tumor (2 cases).All recipients received ABO-compatible donor hearts.Postoperative complications occurred in 12 patients,including cardiac dysfunction,arrhythmia,pulmonary infection,renal dysfunction,and rejection.Two of them experienced cardiac failure and required extracorporeal membrane oxygenation.The immunosuppression regimen was comprised of prednisone,a calcineurin inhibitor,and mycophenolate.All patients recovered with New York Heart Association (NYHA) Class Ⅰ-Ⅱ cardiac function and were discharged.Only one patient suffered sudden death 19 months after transplantation.Conclusion:Orthotopic HTx is a promising therapeutic option with satisfying survival for the pediatric population in China with end-stage heart disease.

  1. Optical determination and magnetic manipulation of a single nitrogen-vacancy color center in diamond nanocrystal

    The controlled and coherent manipulation of individual quantum systems is fundamental for the development of quantum information processing. The nitrogen-vacancy (NV) color center in diamond is a promising system since its photoluminescence is perfectly stable at room temperature and its electron spin can be optically read out at the individual level. We review here the experiments currently realized in our laboratory concerning the use of a single NV color center as the single photon source and the coherent magnetic manipulation of the electron spin associated with a single NV color center. Furthermore, we demonstrate a nanoscopy experiment based on the saturation absorption effect, which allows to optically pin-point a single NV color center at sub-λ resolution. This offers the possibility to independently address two or multiple magnetically coupled single NV color centers, which is a necessary step towards the realization of a diamond-based quantum computer

  2. Optical determination and magnetic manipulation of single nitrogen-vacancy color center in diamond nanocrystal

    Lai, Ngoc Diep; Treussart, François; Roch, Jean-François

    2010-01-01

    The controlled and coherent manipulation of individual quantum systems is a fundamental key for the development of quantum information processing. The nitrogen-vacancy (NV) color center in diamond is a promising system since its photoluminescence is perfectly stable at room temperature and its electron spin can be optically read-out at the individual level. We review here the experiments currently realized in our laboratory, concerning the use of single NV color center as single photon source and the coherent magnetic manipulation of the electron spin associated to a single NV color center. Furthermore, we demonstrate a nanoscopy experiment based on saturation absorption e?ect, which allows to optically pin-point single NV color center at a sub-? resolution. This opens a possibility to independently address two or multiple magnetically-coupled single NV color centers, which is a necessary step toward the realization of a diamond-based quantum computer.

  3. Sensing single remote nuclear spins in nitrogen-vacancy centers

    Honert, Jan; Zhao, Nan; Schmid, Bernhard; Klas, Michael; Fedder, Helmut; Wrachtrup, Joerg [3. Physikalisches Institut, University Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart (Germany); Isoya, Junichi [Graduate School of Library, Information and Media Studies, University of Tsukuba, 1-2 Kasuga, Tsukuba, Ibaraki 305-8550 (Japan); Markham, Matthew; Twitchen, Daniel [Element Six Ltd, Ascot SL5 8BP, Berks (United Kingdom); Jelezko, Fedor [Institut fuer Quantenoptik, Universitaet Ulm, 89081 Ulm (Germany); Liu, Ren-Bao [Department of Physics and Centre for Quantum Coherence, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China)

    2013-07-01

    The detection of single nuclear spins would be useful for fields ranging from basic science to quantum information technology. In addition, the ability to address weakly coupled nuclear spins in the solid state expands the number of addressable qubits surrounding the detector spin significantly. Here, we present the detection and identification of single and remote {sup 13}C nuclear spins embedded in nuclear spin baths surrounding a single electron spin of a nitrogen-vacancy centre in diamond. We are able to amplify and detect the weak magnetic field noise (∝10 nT) from a single nuclear spin located about 3 nm from the centre using dynamical decoupling control, and achieve a detectable hyperfine coupling strength as weak as ∝300 Hz. We also confirm the quantum nature of the coupling present the first steps and results towards manipulating those spins.

  4. 15 Years of Terra MODIS Instrument on-Orbit Performance

    Xiong, X.; Salomonson, V.

    2014-12-01

    The first MODIS instrument, launched on-board the NASA EOS Terra spacecraft in December 1999, has successfully operated for nearly 15 years. MODIS observations have significantly contributed to the studies of many geophysical parameters of the earth's system and its changes over time. Dedicated effort made by the MODIS Characterization Support Team (MCST) to constantly monitor instrument operation, to calibrate changes in sensor response, to derive and update sensor calibration parameters, and to maintain and improve calibration algorithms has played an extremely important role to assure the quality of MODIS data products. MODIS was developed with overall improvements over its heritage sensors. Its observations are made in 36 spectral bands, covering wavelengths from visible to long-wave infrared. The reflective solar bands (1-19 and 26) are calibrated on-orbit by a solar diffuser (SD) panel and regularly scheduled lunar observations. The thermal emissive bands (20-25 and 27-36) calibration is referenced to an on-board blackbody (BB) source. On-orbit changes in the sensor spectral and spatial characteristics are tracked by a spectroradiometric calibration assembly (SRCA). This paper provides an overview of Terra MODIS on-orbit operation and calibration activities implemented from launch to present and the status of instrument health and functions. It demonstrates sensor on-orbit performance derived from its telemetry, on-board calibrators (OBC), and lunar observations. Also discussed in this paper are changes in sensor characteristics, corrections applied to maintain level 1B data quality, various challenging issues, and future improvements.

  5. Clinical spectrum of hypopituitarism in India: A single center experience

    Abhay Gundgurthi

    2012-01-01

    Full Text Available Objectives: There is paucity of information regarding clinical profile of hypopituitarism from India. We report the clinical profile of hypopituitarism from a tertiary center in North India. Materials and Methods: This study was carried out in patients attending our endocrine center between January 2010 and December 2011. All new patients were studied prospectively and those registered before January 2010 retrospectively. Relevant clinical, hormonal, and imaging data were collected. Dynamic testing for pituitary functions was carried out as necessary. Hormonal deficiencies were defined as per prevailing recommendations. Results: This study included 113 subjects. The mean age was 38.6 ± 17.8 years (range, 4 - 76 years. There were 78 (69% males and 35 females (31%. There were 22 subjects aged ≤18 years (childhood and adolescence and 91 adults (>18 years. Visual disturbances were the most common presenting complaint (33%, though headache was the most common symptom (81%. Fifteen percent presented with pituitary apoplexy. Tumors comprised of 84% of cases. Hypogonadism (97% was the most common abnormality seen followed by hypothyroidism (83.2%, hypoadrenalism (79.6%, growth hormone deficiency (88.1% of the 42 patients tested, and diabetes insipidus (13.3%. Panhypopituitarism was seen in 104 (92% patients. There were no cases of hypopituitarism secondary to traumatic brain injury, subarachnoid hemorrhage, central nervous system infections, or cranial irradiation to extrasellar tumors. Conclusion: The most common cause of hypopituitarism at tertiary care center is pituitary tumors and the commonest presenting complaint is visual symptoms. Panhypopituitarism is present in 92% cases.

  6. Acute renal transplant rejections: A single center experience

    Jabur Wael

    2008-01-01

    Full Text Available We undertook this observational study to assess the incidence of acute rejections (AR in the first six months after transplantation at Al-Karama Hospital, Iraq. Sixty eight patients (49 males and 19 females underwent renal transplantation in 2006 and were followed up weekly. Forty six received kidneys from related donors and 22 from unrelated donors. During the first six months after transplantation AR occurred in 16 patients (23%; 11 (23% related and 5 (23% unrelated donor transplantation. We conclude that the incidence of acute rejection was similar in related and unrelated donor transplantation and the general incidence was comparable to that reported from most centers.

  7. Framatome Owners Group achievement after 15 years of operation

    with annual reports (e.g. Performance Indicators Report), Significant Events Reports, Materials Reports, Designer Newsletters or Technical Reports issued from the Joint Programs. Since year 2000, all this documentation has been accessible to FROG Members on a dedicated web site. This modern support of communication allows them also to permanently raise questions and to collect answers. Along those 15 years of operation, the FROG has evolved and has adapted to the needs. There is no doubt that new Memberships and new contents will join it. (authors)

  8. Nanoimplantation and Purcell enhancement of single NV centers in photonic crystal cavities in diamond

    Riedrich-Möller, Janine; Meijer, Jan; Pauly, Christoph; Mücklich, Frank; Markham, Matthew; Edmonds, Andrew M; Becher, Christoph

    2015-01-01

    We present the controlled creation of single nitrogen-vacancy (NV) centers via ion implantation at the center of a photonic crystal cavity which is fabricated in an ultrapure, single crystal diamond membrane. High-resolution placement of NV centers is achieved using collimation of a 5keV-nitrogen ion beam through a pierced tip of an atomic force microscope (AFM). We demonstrate coupling of the implanted NV centers' broad band fluorescence to a cavity mode and observe Purcell enhancement of the spontaneous emission. The results are in good agreement with a master equation model for the cavity coupling.

  9. Portal hypertensive biliopathy: A single center experience and literature review.

    Suárez, Vanessa; Puerta, Andrés; Santos, Luisa Fernanda; Pérez, Juan Manuel; Varón, Adriana; Botero, Rafael Claudino

    2013-03-27

    Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging modalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. PMID:23556047

  10. Surgical complications of hemolytic uremic syndrome: Single center experiences

    Hooman Nakysa

    2007-01-01

    Full Text Available Purpose: To determine the prevalence, outcome and prognostic factors in children with hemolytic uremic syndrome (HUS who underwent laparotomy. Materials and Methods: The medical records of 104 patients with HUS who presented to our center between 1986 and 2003 were reviewed retrospectively. Data were analyzed using Student′s t test for comparing means, Fisher′s exact test for frequencies and Pearson′s correlation for finding the correlations. Results: 78% of cases presented with vomiting and diarrhea. Seven out of 104 needed surgical exploration. The indications of surgery were acute abdomen, severe abdominal distention and the sign of peritonitis. The findings at laparotomy were intussusceptions, perforation (colon, ileum, gangrene of entire colon, rectosigmoidal tearing, duodenal obstruction and toxic megacolon. Pathological findings were transmural infarction in two cases in which staged surgical management was performed (cecostomy, resection, later anastomosis. Four out of seven patients died because of pulmonary failure, coma and multiple organ failure ( P< 0.05 compared to those who did not need laparotomy. The patients requiring surgery were young (< 3 years, had high leukocyte count (>20000 mm 3 and low albumin level (< 3g/dl ( P< 0.05. Conclusion: Surgical complications of HUS are rare but are assorted with high mortality due to respiratory failure and multiple organ failure. Early decision of laparotomy associated with intensive care, including mechanical ventilation, adequate dialysis and ultrafiltration, are recommended.

  11. Efficient coupling of a single diamond color center to propagating plasmonic gap modes

    Kumar, Shailesh; Huck, Alexander; Andersen, Ulrik L

    2013-01-01

    We report on coupling of a single nitrogen-vacancy (NV) center in a nanodiamond to the propagating gap mode of two parallel placed chemically grown silver nanowires. The coupled NV-center nanowire system is made by manipulating nanodiamonds and nanowires with the tip of an atomic force microscope...

  12. Endovascular Treatment of Dural Arteriovenous Fistulas: Single Center Experience

    Oh, Jae-Sang; Oh, Hyuk-Jin; Shim, Jai-Joon; Bae, Hack-Gun; Lee, Kyeong-Seok

    2016-01-01

    Objective Treatment of intracranial dural arteriovenous fistulas (dAVFs) remains a challenge. However, after introduction of Onyx, transarterial approach is the preferred treatment option in many centers. We report our experience of dAVFs embolization with special emphasis on transarterial approach. Methods Seventeen embolization procedures were performed in 13 patients with dAVFs between Jan 2009 and Oct 2014. Clinical symptoms, location and type of fistulas, embolization methods, complications, radiological and clinical outcomes were evaluated using charts and PACS images. Results All 13 patients had symptomatic lesions. The locations of fistulas were transverse-sigmoid sinus in 6, middle fossa dura in 4, cavernous sinus in 2, and superior sagittal sinus in 1 patient. Cognard types were as follows : I in 4, IIa in 2, IIa+IIb in 5, and IV in 2. Embolization procedures were performed ≥2 times in 3 patients. Nine patients were treated with transarterial Onyx embolization alone. One of these required direct surgical puncture of middle meningeal artery. Complete obliteration of fistulas was achieved in 11/13 (85%) patients. There were no complications except for 1 case of Onyx migration in cavernous dAVF. Modified Rankin scale score at post-operative 3 months were 0 in 11, and 3 in 2 patients. Conclusion Transarterial Onyx embolization can be a first line therapeutic option in patients with dAVFs. However, transvenous approach should be tried first in cavernous sinus dAVF because of the risk of intracranial migration of liquid embolic materials. Furthermore, combined surgical endovascular approach can be considered as a useful option in inaccessible route. PMID:26885282

  13. Energy Management of Hybrid Electric Vehicles: 15 years of development at the Ohio State University

    Rizzoni Giorgio

    2015-01-01

    Full Text Available The aim of this paper is to document 15 years of hybrid electric vehicle energy management research at The Ohio State University Center for Automotive Research (OSUCAR. Hybrid Electric Vehicle (HEV technology encompasses many diverse aspects. In this paper we focus exclusively on the evolution of supervisory control strategies for on-board energy management in HEV. We present a series of control algorithms that have been developed in simulation and implemented in prototype vehicles for charge-sustaining HEVs at OSU-CAR. These solutions span from fuzzy-logic control algorithms to more sophisticated model-based optimal control methods. Finally, methods developed for plug-in HEVs energy management are also discussed

  14. Treatment of hepatocellular carcinoma: A single-center experience

    Purpose. The comparative efficacy of transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated. Methods. Two hundred and sixty consecutive patients were retrospectively analyzed: 156 had received between one and six chemoembolization sessions at 3-month intervals, 33 had had PEI, and the remaining 71 patients refused any treatment. The follow-up ranged from 3 to 36 months. Survival rates were statistically analyzed by life-table analysis. Results. Patients' survival was affected by the number of nodules and by the Child's and Okuda's classes; no relationship was found between survival rates and the histologic grade or vascular supply of the tumor. In the case of a single lesion of Okuda's class I, TACE was more effective than PEI. In multifocal HCC, TACE was better than no treatment in Okuda's class I and Child's class A. Conclusion. We suggest TACE as the treatment of choice in Child A or Okuda I patients with multifocal HCCs; it seems of little help in Child B-C or Okuda II-III patients

  15. Endoscopicretrogradecholangiopancreatography outcome from a single referral center in Iran

    Amir H Mohammad Alizadeh; Esmaeil S Afzali; Mirhadi Mousavi; Yaghoub Moaddab; Mohammad R Zali

    2010-01-01

    BACKGROUND: Endoscopic retrograde cholangiopancreato-graphy (ERCP) is the ifrst choice for diagnostic evaluation of the pancreatic and biliary tree and can be accompanied by a high diagnostic sensitivity and a poor therapeutic outcome. In the current study, we described our experiences in the indications, ifndings, and technical success of ERCP in a sample of the Iranian population admitted to a referral center in Iran. METHODS: In a retrospective review database-based study, 780 patients (393 males and 387 females;mean age 57.5 years) who had undergone diagnostic and therapeutic ERCP with the primary diagnosis of hepatobiliary disorder between 2006 and 2008 at Taleghani Hospital in Tehran were reviewed. The key data were demographic characteristics, clinical information, laboratory parameters, as well as post-ERCP complications. RESULTS: A history of cholecystectomy was found in about one-third (36.3%) of participants and 80 (10.3%) out of 780 patients had a previous history of biliary stone. A minority (1.4%) of the patients suffered from hepatobiliary carcinomas, and 11 patients had cirrhosis. The most common clinical manifestations in the patients undergoing diagnostic ERCP were icterus (47.3%), weight loss (31.2%), and dark urine (26.9%). Selective biliary cannulation was technically successful in 87.0% of the patients; however, cannulation failed in 13.0%. The most frequent ifnal diagnosis of ERCP was common bile duct stone that was detected in 40.1% of the patients. The ERCP results in 11.0%of the patients were normal. Regarding appropriate treatment, successful stenting was performed in 43 patients (15.2%). Among post-ERCP complications, pancreatitis was the most adverse event with an incidence rate of 3.3%. Other complications including local bleeding, cholangitis and gastrointestinal perforation, rarely occurred. Post-ERCP pancreatitis was reported in 1.8%of men and 3.6%of women (P=0.120). Pancreatitis was more common in women below 70 years than

  16. Controlled Coupling of a Single Nitrogen-Vacancy Center to a Silver Nanowire

    Huck, Alexander; Kumar, Shailesh; Shakoor, Abdul; Andersen, Ulrik Lund

    2011-01-01

    We report on the controlled coupling of a single nitrogen-vacancy (NV) center to a surface plasmon mode propagating along a chemically grown silver nanowire (NW). We locate and optically characterize a single NV center in a uniform dielectric environment before we controllably position this emitter...... in the close proximity of the NW. We are thus able to control the coupling of this particular emitter to the NW and directly compare the photon emission properties before and after the coupling. The excitation of single plasmonic modes is witnessed and a total rate enhancement by a factor of up to 4...

  17. Dark states of single NV centers in diamond unraveled by single shot NMR

    Waldherr, G.; Beck, J; Steiner, M; Neumann, P; Gali, A.; Frauenheim, Th.; Jelezko, F.; Wrachtrup, J.

    2010-01-01

    The nitrogen-vacancy (NV) center in diamond is supposed to be a building block for quantum computing and nanometer scale metrology at ambient conditions. Therefore, precise knowledge of its quantum states is crucial. Here, we experimentally show that under usual operating conditions the NV exists in an equilibrium of two charge states (70% in the expected negative (NV-) and 30% in the neutral one (NV0)). Projective quantum non-demolition measurement of the nitrogen nuclear spin enables the de...

  18. Vaginal Radical Trachelectomy for early stage cervical cancer. Results of the Danish National Single Center Strategy

    Hauerberg, L; Høgdall, C; Loft, A;

    2015-01-01

    OBJECTIVE: To present and evaluate an unselected national single center strategy with fertility preserving trachelectomy in cervical cancer. In 2003 nationwide single-center referral of women for trachelectomies was agreed upon between all Danish departments performing cervical cancer surgery with...... the purpose of increasing volume, to increase surgical safety and facilitate follow-up. METHODS: Prospective data were recorded in the Danish Gynecological Cancer Database of all Vaginal Radical Trachelectomies (VRT) performed in Denmark between 2002 and 2013. Oncologic, fertility and obstetrical...... total of 77 pregnancies. Of the 72 women 40 were referred to fertility treatment. First and second trimester miscarriage rates were 21.6% and 2.7%, respectively. A total of 53 children were born of which 41 were delivered after gestational week 34. CONCLUSION: This unselected national single center...

  19. Color center fluorescence and spin manipulation in single crystal, pyramidal diamond tips

    Nelz, Richard; Opaluch, Oliver; Sonusen, Selda; Savenko, Natalia; Podgursky, Vitali; Neu, Elke

    2016-01-01

    We investigate bright fluorescence of nitrogen (NV)- and silicon-vacancy color centers in pyramidal, single crystal diamond tips which are commercially available as atomic force microscope probes. We coherently manipulate NV electronic spin ensembles with $T_2 = 7.7(3)\\,\\mu$s. Color center lifetimes in different tip heights indicate effective refractive index effects and quenching. Using numerical simulations, we verify enhanced photon rates from emitters close to the pyramid apex; a situation promising for scanning probe sensing.

  20. Dark states of single nitrogen-vacancy centers in diamond unraveled by single shot NMR.

    Waldherr, G; Beck, J; Steiner, M; Neumann, P; Gali, A; Frauenheim, Th; Jelezko, F; Wrachtrup, J

    2011-04-15

    The nitrogen-vacancy (NV) center in diamond is supposed to be a building block for quantum computing and nanometer-scale metrology at ambient conditions. Therefore, precise knowledge of its quantum states is crucial. Here, we experimentally show that under usual operating conditions the NV exists in an equilibrium of two charge states [70% in the expected negative (NV-) and 30% in the neutral one (NV0)]. Projective quantum nondemolition measurement of the nitrogen nuclear spin enables the detection even of the additional, optically inactive state. The nuclear spin can be coherently driven also in NV0 (T1≈90  ms and T2≈6  μs). PMID:21568615

  1. Acute post-infectious glomerulonephritis in adults: A single center report

    Mouna Hamouda

    2014-01-01

    Full Text Available Acute post-infectious glomerulonephritis (APIGN is uncommonly seen in adults; its incidence is progressively declining, particularly in developed countries. The aim of this study was to evaluate the epidemiological, clinical and biologic features of APIGN in a Tunisian center. A retrospective descriptive analytic study was carried out on 50 patients aged more than 15 years who were admitted to the Monastir Hospital between 1991 and 2007, with a diagnosis of APIGN. There were more males than females (66% vs. 34%, and the mean age of the patients was 36.8 ± 10 years. Only 10% had an immunocompromised background, including diabetes. The most common site of infection was upper respiratory tract, followed by skin and pneumonia. The most common causative agent was Streptococcus (66%, followed by Staphylococcus (12%. 73.8% of the patients had low C3 complement levels. The mean peak serum creatinine was 190 μmol, and 4% of patients required acute dialysis. The patients were followed-up for a mean period of 18 months (range, 0.16-97 months. During follow-up, of the 46 patients reviewed in the consultation, the majority showed complete remission, 12 patients had persisting abnormalities such as hypertension in 17%, chronic renal failure in 8% and proteinuria in 6.5%, and one patient had concomitant hypertension and chronic renal failure. Our study suggests that APIGN is still endemic in some parts of the world such as Tunisia, and our data showed a favorable prognosis in adults.

  2. Nanoscale fluorescence lifetime imaging of an optical antenna with a single diamond NV center.

    Beams, Ryan; Smith, Dallas; Johnson, Timothy W; Oh, Sang-Hyun; Novotny, Lukas; Vamivakas, A Nick

    2013-08-14

    Solid-state quantum emitters, such as artificially engineered quantum dots or naturally occurring defects in solids, are being investigated for applications ranging from quantum information science and optoelectronics to biomedical imaging. Recently, these same systems have also been studied from the perspective of nanoscale metrology. In this letter, we study the near-field optical properties of a diamond nanocrystal hosting a single nitrogen vacancy center. We find that the nitrogen vacancy center is a sensitive probe of the surrounding electromagnetic mode structure. We exploit this sensitivity to demonstrate nanoscale fluorescence lifetime imaging microscopy (FLIM) with a single nitrogen vacancy center by imaging the local density of states of an optical antenna. PMID:23815462

  3. Brief Report: Pregnant by Age 15 Years and Substance Use Initiation among US Adolescent Girls

    Cavazos-Rehg, Patricia A.; Krauss, Melissa J.; Spitznagel, Edward L.; Schootman, Mario; Cottler, Linda B.; Bierut, Laura Jean

    2012-01-01

    We examined substance use onset and associations with pregnancy by age 15 years. Participants were girls ages 15 years or younger (weighted n = 8319) from the 1999-2003 Youth Risk Behavior Surveillance System (YRBS). Multivariable logistic regression examined pregnancy as a function of substance use onset (i.e., age 10 years or younger, 11-12,…

  4. Two-effective-center approximation for proton-impact single ionization of hydrogen molecules

    Some closed-form expressions are derived for the partial direct and indirect transition amplitudes for proton-impact single ionization of the hydrogen molecules using a first-order two-effective center continuum-wave approximation. The method satisfies the correct boundary conditions in the entrance channel. The basic assumption in this model is that when the active electron is ionized from one of the atomic centers in the molecule, the other scattering center is completely screened by the passive electron. Consequently, the transition amplitude can be expressed as a superposition of the partial ionization amplitudes from two independent scattering centers located at a constant distance from each other. The superposition of the partial amplitudes leads to different interference patterns for various orientations of the molecular target. The calculated cross sections are compared with the experiments and also with other theories. The comparison shows that the present results are reliable. (author)

  5. Vector magnetic field sensing by a single nitrogen vacancy center in diamond

    Chen, X.-D.; Sun, F.-W.; Zou, C.-L.; Cui, J.-M.; Zhou, L.-M.; Guo, G.-C.

    2013-03-01

    In this letter, we proposed and experimentally demonstrated a method to detect the vector magnetic field with a single nitrogen vacancy (NV) center in diamond. The magnetic field in parallel with the axis of the NV center can be obtained by detecting the electron Zeeman shift, while the Larmor precession of an ancillary nuclear spin close to the NV center can be used to measure the field perpendicular to the axis. Experimentally, both the Zeeman shift and Larmor precession can be measured through the fluorescence from the NV center. By applying additional calibrated magnetic fields, complete information on the vector magnetic field can be achieved with such a method. This vector magnetic-field detection method is insensitive to temperature fluctuation and it can be applied to nanoscale magnetic measurements.

  6. Surgical management of carotid body tumors: a 15-year single institution experience employing an interdisciplinary approach

    Dixon, Jennifer L.; Atkins, Marvin D.; Bohannon, William T.; Buckley, Clifford J.; Lairmore, Terry C.

    2016-01-01

    Cervical paragangliomas are rare neoplasms that arise from extraadrenal paraganglia in close association with the cranial nerves and extracranial arterial system of the head and neck, and therefore surgical extirpation can be challenging. A retrospective study was conducted of all patients undergoing surgical excision of a cervical paraganglioma between 2000 and 2015. The demographic characteristics, clinical features, surgical approach, and outcomes were reviewed. A total of 20 cervical para...

  7. Pulmonary hypertension and pregnancy: The experience of a tertiary institution over 15 years

    John Monagle

    2015-01-01

    Full Text Available Background: Pulmonary hypertension (PH in pregnancy is associated with a high maternal mortality and morbidity and has been found to be as high as 30-56%. Aim: To review the management of such patients in a tertiary center over a 15 year period, as the current literature consists of a few case reports, a few small case series and 2 meta-analyses. Materials and Methods: A review of all patients admitted to our institution for management of PH in pregnancy between 1994 and February 2009 was undertaken. Cases were identified from the high-risk pregnancy database within the department of anesthesia and from the hospital medical records. Severity of PH, type of PH, NYHA functional status at presentation and delivery, mode of delivery, peripartum monitoring and APGAR scores were noted. Patients were reviewed by a multidisciplinary team and management planned accordingly. Results: 19 eligible patients were identified. Patients who were significantly sick due to their PH were aggressively managed during pregnancy. Overall there was an improvement in NYHA functional status at the time of delivery. Epidural analgesia and anesthesia for labor and operatively delivery seem to be the ideal choice. Conclusion: Multidisciplinary approach is a key to the successful management of these patients. Secondary PH results in higher morbidity and mortality, in particular, older the age higher the maternal morbidity and mortality.

  8. Fifteen years of kidney biopsies in children: A single center in Egypt

    Ashraf Bakr

    2014-01-01

    Full Text Available This study retrospectively investigates the indications and results of renal biopsy in children to determine the patterns of childhood kidney disease in a single tertiary children′s hospital in Egypt. We included all the patients who underwent ultrasound-guided renal biopsy from 1998 to 2012. All the kidney biopsies were studied under light microscopy, while immunofluorescence and electron microscopy were performed when indicated. A total of 1246 renal biopsies were performed over 15 years, on 1096 patients. The mean age of the patients at the time of biopsy was 9.2 ± 3.7 years. The main indication for a biopsy was the steroid-resistant nephrotic syndrome (n = 354, 28.4%, followed by the atypical nephrotic syndrome (n = 250, 20.1%, and renal abnormalities in the systemic diseases (n = 228, 18.3 %. In the 1226 pathologically diagnosed specimens, primary glomerulonephritis was the most common finding (n = 826, 67.4%, followed by secondary glomerulonephritis (n = 238, 19.4%. The most common causes of primary glomerulonephritis were Minimal Change Disease (MCD (n = 267, 21.8%, diffuse proliferative glomerulonephritis (n = 188, 15. 3%, and focal proliferative glomerulonephritis (n = 164, 13.3%. Lupus nephritis (n = 209, 17% was the most common cause of secondary glomerulonephritis. We conclude that the steroid-resistant nephrotic syndrome was the most frequent indication for biopsy and minimal change disease was the most common histopathological finding in our population.

  9. 15 Years of Ocean Education and Outreach Activities by the College of Exploration.

    Tuddenham, P.; Bishop, K.

    2012-04-01

    Since 1997 the College of Exploration has created ocean related interactive and engaging online and onsite education and outreach programs that have reached over 15,000 particpants in over 30 countries. Partners and funders have included in the USA the National Oceanic and Atmospheric Administration (NOAA), NASA, the National Science Foundation (NSF), National Geographic, and many others. In the UK the Natural Environment Research Council and the National Oceanography Center, and in Europe Portugal's Ciencia Viva. The first online and onsite program was in partnership with the now Bermuda Institute for Ocean Sciences. With funding from NSF the project took the online Bermuda Atlanic Time Series (BATS) dataset and made it more accessible to teachers and students in a custom spreadsheet with easier to use macros and graphs. Online training and workshops helped teachers learn more about using BATS in the classroom. The next project in 1998 in partnership with the University of Southern California Sea Grant was an online workshop on El Nino. This was one of the first teacher professional development projecs offered online. Scientists with expertise in El Nino were able to meet and discuss with teachers. Over the past 15 years there have numerous programs, workshops and activities on topics such as Autosub Under Ice, Ocean Exploration then,now and the future, Ocean Observing Systems, Harmful Algal Blooms, Coral Reefs, and much more. These will be summarized. Every activity has been evaluated and assessed. The cumulative results of these evaluations will be presented along with the results of a recent survey of all participants over the past 15 years. Since 2002 the College of Exploration has played a key role in the development and promotion of the Ocean Literacy campaign, an effort to bring innovative approaches to promoting the ocean in K-12 education as well integrating the ocean into national standards and curriculum and promoting the ocean to the general public. A

  10. Performance characteristics of single effect lithium bromide/ water absorption chiller for small data centers

    Mysore, Abhishek Arun Babu

    A medium data center consists of servers performing operations such as file sharing, collaboration and email. There are a large number of small and medium data centers across the world which consume more energy and are less efficient when compared to large data center facilities of companies such as GOOGLE, APPLE and FACEBOOK. Such companies are making their data center facilities more environmental friendly by employing renewable energy solutions such as wind and solar to power the data center or in data center cooling. This not only reduces the carbon footprint significantly but also decreases the costs incurred over a period of time. Cooling of data center play a vital role in proper functioning of the servers. It is found that cooling consumes about 50% of the total power consumed by the data center. Traditional method of cooling includes the use of mechanical compression chillers which consume lot of power and is not desirable. In order to eliminate the use of mechanical compressor chillers renewable energy resources such as solar and wind should be employed. One such technology is solar thermal cooling by means of absorption chiller which is powered by solar energy. The absorption chiller unit can be coupled with either flat plate or evacuated tube collectors in order to achieve the required inlet temperature for the generator of the absorption chiller unit. In this study a modular data center is considered having a cooling load requirement of 23kw. The performance characteristics of a single stage Lithium Bromide/ water refrigeration is presented in this study considering the cooling load of 23kw. Performance characteristics of each of the 4 heat exchangers within the unit is discussed which helps in customizing the unit according to the users' specific needs. This analysis helps in studying the importance of different properties such as the effect of inlet temperatures of hot water for generator, inlet temperatures of cooling water for absorber and

  11. ESR of trapped centers in γ irradiated silver chlorates single crystals

    The paramagnetic centers O-3, ClO2, and (ClO2--Cl)- have been identified in irradiated AgClO3 single crystals by X and Q band ESR experiments at room temperatures and by the optical absorption bands at 480 and 360 nm, characteristic of the first two centers, respectively. The ESR spectrum and its angular dependence show that the first two centers have two magnetically inequivalent sites per unit cell. The third center was clearly observed only at certain orientations. The data for ClO2 show that the principal directions of the g and A tensors do not coincide; the two magnetically inequivalent sites have similar principal values of the g and A tensors related by a 900 rotation about the tetragonal crystal axis of symmetry, and can therefore be assumed to be chemically equivalent. It is found that the ClO2 center is formed substitutionally in the ClO-3 ion position, but that the ozonide O-3 is not. The thermal annealing of the γ irradiated AgClO3 has revealed an increase in the concentration of the O-3 radical that seems to be connected with the simultaneous destruction of the ClO2 center

  12. Transcatheter arterial embolization as therapy of renal angiomyolipomas: The evolution in 15 years of experience

    Objective: This study aims at presenting the evolution of the embolization technique in treating renal angiomyolipomas (AMLs) either diagnosed in patients with acute bleeding or discovered accidentally. Methods: Ten patients with renal AMLs have been through thirteen selective transcatheter arterial embolizations for 15 years. Two patients had tuberous sclerosis complex (TSC) with bilateral tumors and were embolized twice. Four embolic materials were employed: PVA particles, Gianturco coils, microspheres and microcoils. Catheterization was achieved by means of 5F Cobra 2 catheters and coaxial microcatheter systems. Results: On an emergency basis, embolization was a first-line treatment. In one case, surgery was necessary; in two patients, a second embolization was performed. When treatment was preventive, a single embolization proved to be sufficient, as well. There was no significant deterioration of the serum creatinine levels in the post-embolization period. Conclusion: Selective arterial embolization is a rather safe and effective technique to treat AMLs both urgently and preventively. Different embolic materials can be employed. Microspheres and microcatheters stand for new promising materials

  13. Reanalysis of archived IMPROVE PM2.5 samples previously analyzed over a 15-year period.

    Hyslop, Nicole P; Trzepla, Krystyna; White, Warren H

    2012-09-18

    The IMPROVE (Interagency Monitoring of Protected Visual Environments) network has collected airborne particulate matter (PM) samples at locations throughout the United States since 1988. These samples have been analyzed for elemental content using analytical methods that evolved over the years. Changes in analytical methods sometimes introduced shifts in reported concentrations that are evident in the historical record. We sought to illuminate the effects of methodological changes by reanalyzing archived samples with current methods. To test the feasibility of this approach, the 15-year archive of PM samples from Great Smoky Mountains National Park was selected for reanalysis as a single analytical batch using a common protocol and calibration. Comparisons of the reanalyses and original analyses indicate that concentrations of all but one measured element, Br, remained stable on the filters over years of storage. The agreement between the two analyses varied with element and original measurement method. For elements measured well above their contemporary detection limits - S, K, Ca, Fe, and Zn - the reanalysis established that method changes had limited impacts on reported concentrations, generally record, many of which were previously recognized and documented as method-related. PMID:22913377

  14. Transcatheter arterial embolization as therapy of renal angiomyolipomas: The evolution in 15 years of experience

    Chatziioannou, A.; Gargas, D. [University of Athens, Aretaieion Hospital, Radiology Department (Greece); Malagari, K. [University of Athens, Imaging and Research Unit, Evgenidion Hospital (Greece); Kornezos, I., E-mail: kornezos@gmail.com [University of Athens, Aretaieion Hospital, Radiology Department (Greece); Ioannidis, I.; Primetis, E. [University of Athens, Aretaieion Hospital, Radiology Department (Greece); Moschouris, H. [University of Athens, Imaging and Research Unit, Evgenidion Hospital (Greece); Gouliamos, A.; Mourikis, D. [University of Athens, Aretaieion Hospital, Radiology Department (Greece)

    2012-09-15

    Objective: This study aims at presenting the evolution of the embolization technique in treating renal angiomyolipomas (AMLs) either diagnosed in patients with acute bleeding or discovered accidentally. Methods: Ten patients with renal AMLs have been through thirteen selective transcatheter arterial embolizations for 15 years. Two patients had tuberous sclerosis complex (TSC) with bilateral tumors and were embolized twice. Four embolic materials were employed: PVA particles, Gianturco coils, microspheres and microcoils. Catheterization was achieved by means of 5F Cobra 2 catheters and coaxial microcatheter systems. Results: On an emergency basis, embolization was a first-line treatment. In one case, surgery was necessary; in two patients, a second embolization was performed. When treatment was preventive, a single embolization proved to be sufficient, as well. There was no significant deterioration of the serum creatinine levels in the post-embolization period. Conclusion: Selective arterial embolization is a rather safe and effective technique to treat AMLs both urgently and preventively. Different embolic materials can be employed. Microspheres and microcatheters stand for new promising materials.

  15. Deterministic coupling of a single nitrogen vacancy center to a photonic crystal cavity

    Englund, Dirk; Rivoire, Kelley; Hatami, Fariba; Vuckovic, Jelena; Park, Hongkun; Lukin, Mikhail D

    2010-01-01

    We describe and experimentally demonstrate a technique for deterministic coupling between a photonic crystal (PC) nanocavity and single emitters. The technique is based on in-situ scanning of a PC cavity over a sample and allows the positioning of the cavity over a desired emitter with nanoscale resolution. The power of the technique, which we term a Scanning Cavity Microscope (SCM), is demonstrated by coupling the PC nanocavity to a single nitrogen vacancy (NV) center in diamond, an emitter system that provides optically accessible electron and nuclear spin qubits.

  16. Early outcomes of transcatheter aortic valve replacement in patients with severe aortic stenosis: single center experience

    Bozkurt, Engin; KELEŞ, TELAT; Durmaz, Tahir; Akçay, Murat; Sari, Cenk; Ayhan, Hüseyin; Bayram, Nihal Akar; Aslan, Abdullah Nabi; Baştuğ, Serdal; Bilen, Emine

    2014-01-01

    Introduction Transcatheter aortic valve implantation is a promising alternative to high risk surgical aortic valve replacement. The procedure is mainly indicated in patients with severe symptomatic aortic stenosis who cannot undergo surgery or who are at very high surgical risk. Aim Description early results of our single-center experience with balloon expandable aortic valve implantation. Material and methods Between July 2011 and August 2012, we screened in total 75 consecutive patients wit...

  17. Presentation of 493 Consecutive Girls with Idiopathic Central Precocious Puberty: A Single-Center Study

    Eloïse Giabicani; Slimane Allali; Adélaïde Durand; Julie Sommet; Ana-Claudia Couto-Silva; Raja Brauner

    2013-01-01

    BACKGROUND: Despite the number of reported data concerning idiopathic central precocious puberty (CPP) in girls, major questions remain including its diagnosis, factors, and indications of gonadotropin releasing hormone (GnRH) analog treatment. METHODS: A retrospective, single-center study was carried out on 493 girls with CPP. RESULTS: Eleven girls (2.2%) were aged less than 3 years. Breast development was either isolated (Group 0, n = 99), or associated with one sign, pubic hair development...

  18. Various anatomic locations of surgically proven endometriosis: A single-center experience

    Lee, Hyun Ju; Park, Ye Mi; Jee, Byung Chul; Kim, Yong Beom; Suh, Chang Suk

    2015-01-01

    Objective To report the various anatomic locations of surgically and pathologically proven endometriosis. Methods Pathologic reports (n=1,376) of women who underwent surgeries at a single center between April 2005 and March 2013 were retrieved from the electronic medical record system of the hospital. Pathologic reports were included after performing a search by using the key-words "endometrial cyst," "endometriotic cyst," "endometriosis," or "endometrioma." Only reports dealing with female p...

  19. Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience.

    Erkan, Murat Mert; Michalski, Christoph W.; Kong, Bo; Jaeger, Carsten; Kloe, Silke; Beier, Barbara; Braren, Rickmer; Esposito, Irene; Friess, Helmut; Kleeff, Jorg

    2015-01-01

    RESEARCH ARTICLE Open Access Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience Christoph W. Michalski1,4, Bo Kong1, Carsten Jäger1, Silke Kloe1, Barbara Beier1, Rickmer Braren2, Irene Esposito3,5, Mert Erkan1,6, Helmut Friess1† and Jorg Kleeff1*† Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) patients frequently present with borderline resectable disease, which can be due to invasion of the ...

  20. Pediatric pulmonary hodgkin lymphoma: Analysis of 10 years data from a single center

    Urasinski, T; Kamienska, E; Gawlikowska-Sroka, A; Ociepa, T; Maloney, E.; Chosia, K; Walecka, A

    2010-01-01

    Several reports indicate that lungs are the extralymphatic site most commonly affected in patients with Hodgkin lymphoma; however, the data in children are rather limited. This retrospective study aimed to assess the frequency, clinical picture, and the impact on prognosis in children with pulmonary Hodgkin lymphoma, who were diagnosed and treated in a single center during a 10-year period. Pulmonary lesions related to HL: nodules and parenchymal infiltrates with cavitations were found in 3 o...

  1. Electronic transitions of single silicon vacancy centers in the near-infrared spectral region

    Neu, Elke; Albrecht, Roland; Fischer, Martin; Gsell, Stefan; Schreck, Matthias; Becher, Christoph

    2012-06-01

    Photoluminescence (PL) spectra of single silicon vacancy (SiV) centers in diamond frequently feature very narrow room temperature PL lines in the near-infrared (NIR) spectral region, mostly between 820 nm and 840 nm, in addition to the well known zero-phonon line (ZPL) at approximately 738 nm [E. Neu , Phys. Rev. BPRBMDO1098-012110.1103/PhysRevB.84.205211 84, 205211 (2011)]. We here exemplarily prove for a single SiV center that this NIR PL is due to an additional purely electronic transition (ZPL). For the NIR line at 822.7 nm, we find a room temperature linewidth of 1.4 nm (2.6 meV). The line saturates at similar excitation power as the ZPL. The ZPL and NIR line exhibit identical polarization properties. Cross-correlation measurements between the ZPL and the NIR line reveal anticorrelated emission and prove that the lines originate from a single SiV center, furthermore indicating a fast switching between the transitions (0.7 ns). g(2) autocorrelation measurements exclude that the NIR line is a vibronic sideband or that it arises due to a transition from/to a metastable (shelving) state.

  2. Physical Activity in U.S. Youth Aged 12-15 Years, 2012

    ... Order from the National Technical Information Service NCHS Physical Activity in U.S. Youth Aged 12–15 Years, 2012 ... percentage of youth engaged in moderate-to-vigorous physical activity for at least 60 minutes each day? About ...

  3. 15 years of Forest Certification in the European Union. Are we doing things right?

    Gafo Gomez-Zamalloa, Maria; Caparros, Alejandro; San Miguel Ayanz, Alfonso

    2011-01-01

    Forest certification is one of the most important issues that have entered the forest sector in the past 15 years. There are many detractors and supporters of this instrument, but merely looking at the number of hectares certified and products carrying the logo of certification, one cannot deny that certification has gained importance, year after year. The overall objective of this study is to evaluate the effect of 15 years of forest certification in the EU forest-based sector, using the Del...

  4. CARDIAC RUPTURE IN MYOCARDIAL INFARCTION: INCIDENCE AND PREDISPOSING FACTORS (15 YEAR FOLLOW-UP

    V. A. Shulman

    2015-12-01

    Full Text Available Aim. To evaluate the incidence of cardiac rupture (CR in patients with acute myocardial infarction (MI as well as predisposing factors during 15-year follow-up.Material and methods. 1453 patients with acute MI who were admitted to Krasnoyarsk cardiological center during 1989, 1993 and 2003 years were studied. All patients were divided into three groups: group I - 447 patients, who were on treatment in 1989, group II - 475 patients of 1993, and group III – 531 patients of 2003. There were no differences in groups on patient sex, location and depth of MI, previous MI, arrhythmias, heart failure and diabetes mellitus.Results. CR was found in 18 of 447 patients (4% of group I (1989, in 16 of 475 patients (3,4% of group II (1993 and in 10 of 531 patients (1,9% of group 3 (2003, (p1,3 <0,05. Incidence of CR significantly decreased from 1989 to 2003 in female patients (7,2%; 5,7% and 1,6% in 1989, 1993 and 2003, respectively; p1,3 < 0,01, p2,3 < 0,05. Incidence of CR in male patients didn’t changed (2,5%, 1,8% and 2,1%, respectively. The average blood pressure (BP during the first day of MI in female patients was higher than this in male ones in 1989 and 1993. There were no significant differences in BP between women and men in 2003. Heart rate (HR during the first day of MI in female patients was higher than this in male patients in 1989. However in 1993 and 2003 there were no differences in HR between women and men. MI therapy more often included betablockers, angiotensin converting enzyme inhibitors, intravenous nitrates, statins, thrombolythics and anticoagulants in 2003 than in 1989 and 1993.Conclusion. Effective BP and HR control is the most effective way to prevent CR in patients with MI.

  5. The Effect of Age Group under 15 Years on Cholera Morbidity During the Past 10 Years in Iran (1996-2005

    Seyed Mohsen Zahraei

    Full Text Available Objective: The study of the effect of age, especially children under 15 years, on cholera morbidity during a period of ten years (1996-2005 was carried out in Iran. There are no other studies on this topic in Iran and other countries.Methods: In this cross sectional study, we used cholera surveillance data collected in Center for Disease Control. All cholera cases were divided into two groups: under 15 years and above 15 years. Incidence rate of cholera per 100000 was calculated in total population and the two mentioned groups during 10 years. The relative risk of less than 15 year-olds group to above 15 year-olds was calculated with95 % CI for 10 years by EPI6 and SPSS software.Findings: The trend of cholera incidence during the past 10 years shows two epidemic peaks in 1998 and 2005 by the rate of 15.7 and 1.63 per 100000, respectively. During the year with no epidemic and the years between two peaks, the age group under 15 year-olds was more affected with significant relative risk. For example, in 2001 this rate was 4.53. So, we can consider this age group as a risk factor to cholera morbidity. The age group of above 15 year-olds was more affected to cholera during epidemic years (1998, 2005 and relative risk was less than one. So, the age was protective on cholera morbidity for children in these years.Conclusion: One of the most important causes of periodic cholera epidemics every 5-6 years is changing of herd immunity. During the years between two epidemics adults have sufficient immunity and children are more affected because of first exposure and less immunity. With reduced herd immunity epidemics occur. We recommend continuing and strengthening of cholera surveillance system for detection of epidemics and treatment of highly sensitive age groups.

  6. Multimode and single-mode fibers for data center and high-performance computing applications

    Bickham, Scott R.

    2016-03-01

    Data center (DC) and high performance computing (HPC) applications have traditionally used a combination of copper, multimode fiber and single-mode fiber interconnects with relative percentages that depend on factors such as the line rate, reach and connectivity costs. The balance between these transmission media has increasingly shifted towards optical fiber due to the reach constraints of copper at data rates of 10 Gb/s and higher. The percentage of single-mode fiber deployed in the DC has also grown slightly since 2014, coinciding with the emergence of mega DCs with extended distance needs beyond 100 m. This trend will likely continue in the next few years as DCs expand their capacity from 100G to 400G, increase the physical size of their facilities and begin to utilize silicon-photonics transceiver technology. However there is a still a need for the low-cost and high-density connectivity, and this is sustaining the deployment of multimode fiber for links concept which provides intra-and inter-rack connectivity as well as compatibility with silicon-photonic transceivers operating at 1310 nm. We also discuss the trade-offs between single-mode fiber attributes such as bend-insensitivity, attenuation and mode field diameter and their roles in capacity and connectivity in data centers.

  7. Robust Dynamical Decoupling for Arbitrary Quantum States of a Single NV Center in Diamond

    Shim, J H; Zhang, J; Suter, D

    2012-01-01

    Dynamical decoupling is a powerful technique for extending the coherence time (T$_2$) of qubits. We apply this technique to the electron spin qubit of a single nitrogen-vacancy center in type IIa diamond. In a crystal with natural abundance of $^{13}$C nuclear spins, we extend the decoherence time up to 2.2 ms. This is the longest value reported to date and is close to the T1 value of this NV center (4 ms). Since of dynamical decoupling must perform well for arbitrary initial conditions, we measured the dependence on the initial state and compared the performance of different sequences with respect to initial state dependence and robustness to experimental imperfections.

  8. Post-Transplant Lymphoproliferative Disorder in Kidney Transplant Recipients: A Single-Center Experience in Japan.

    Ishihara, Hiroki; Shimizu, Tomokazu; Unagami, Kohei; Hirai, Toshihito; Toki, Daisuke; Omoto, Kazuya; Okumi, Masayoshi; Imai, Yoichi; Ishida, Hideki; Tanabe, Kazunari

    2016-04-01

    Post-transplant lymphoproliferative disorder is a serious complication of solid organ transplantation; however, few large studies have been performed in Asian institutions. We review our single-center experience with post-transplant lymphoproliferative disorder patients in Japan. We retrospectively evaluated patients with post-transplant lymphoproliferative disorder following kidney transplantation between January 1985 and December 2013. The patients were divided into early-onset post-transplant lymphoproliferative disorder ( 10 years after transplantation; therefore, long-term monitoring of patients is needed. PMID:26948427

  9. Midgap luminescence centers in single-wall carbon nanotubes created by ultraviolet illumination

    Iakoubovskii, Konstantin; Minami, Nobutsugu; Kim, Yeji; Miyashita, Kanae; Kazaoui, Said; Nalini, Balakrishnan

    2006-10-01

    The authors report the effect of ultraviolet (UV) illumination on optical properties of single-wall carbon nanotubes (SWCNTs) isolated using various dispersants. It is demonstrated that even weak UV light (˜1mW/cm2) can irreversibly alter the SWCNT structure, thus resulting in the emergence of hitherto unknown, redshifted photoluminescence (PL) peaks with concomitant reduction in some of the original PL peaks. These UV-induced changes are characterized in detail and attributed to the creation of midgap PL centers.

  10. Clinical Features and Genetic Background of the Periodic Fever Syndrome with Aphthous Stomatitis, Pharyngitis, and Adenitis: A Single Center Longitudinal Study of 81 Patients

    Daša Perko

    2015-01-01

    Full Text Available PFAPA syndrome is the most common autoinflammatory disorder in childhood with unknown etiology. The aim of our study was clinical evaluation of PFAPA patients from a single tertiary care center and to determine whether variations of AIM2, MEFV, NLRP3, and MVK genes are involved in PFAPA pathogenesis. Clinical and laboratory data of consecutive patients with PFAPA syndrome followed up at the University Children’s Hospital, Ljubljana, were collected from 2008 to 2014. All four genes were PCR amplified and directly sequenced. Eighty-one patients fulfilled criteria for PFAPA syndrome, 50 (63% boys and 31 (37% girls, with mean age at disease onset of 2.1 ± 1.5 years. Adenitis, pharyngitis, and aphthae were present in 94%, 98%, and 56%, respectively. Family history of recurrent fevers in childhood was positive in 78%. Nineteen variants were found in 17/62 (27% patients, 4 different variants in NLRP3 gene in 13 patients, and 6 different variants in MEFV gene in 5 patients, and 2 patients had 2 different variants. No variants of clinical significance were found in MVK and AIM2 genes. Our data suggest that PFAPA could be the result of multiple low-penetrant variants in different genes in combination with epigenetic and environmental factors leading to uniform clinical picture.

  11. Extinction of Light and Coherent Scattering by a Single Nitrogen-Vacancy Center in Diamond

    Tran, Thai Hien; Gerhardt, Ilja

    2016-01-01

    Coherently scattered light from a single quantum system promises to get a valuable quantum resource. In this letter an external laser field is efficiently coupled to a single nitrogen vacancy (NV-)center in diamond. By this it is possible to detect a direct extinction signal and estimate the NV's extinction cross-section. The exact amount of coherent and incoherent photons is determined against the saturation parameter, and reveals the optimal point of generating coherently scattered photons and an optimal point of excitation. A theoretical model of spectral diffusion allows to explain the deviation to an atom in free-space. The introduced experimental techniques are used to determine the properties of the tight focusing in an interference experiment, and allow for a direct determination of the Gouy-phase in a strongly focused beam.

  12. INFECTIONS IN THE INTENSIVE CARE UNIT FOLLOWING LIVER TRANSPLANTATION: PROFILE OF A SINGLE CENTER

    E. Otan

    2013-01-01

    Full Text Available Introduction. Despite the advances in antibiotherapy and critical care management, infectious complications remain among the leading complications after liver transplantation related with mortality and morbidity. This study analysis the incidence and pattern of infections and possible prognostic factors of infectious compli- cations retrospectively in a single center. Patients and Methods. Results of 30 consecutive patients with a primary liver transplantation history in a single center between August 2011 and August 2012 and a positive culture result in the first month in the ICU were analysed retrospectively. Results. During the first 1 month stay in the ICU postoperatively 30 (13,63% patients had at least 1 infection. Total number of infections were 68. Mortality rate of the infected patients was 53,3% (n = 16. Among these infections, 25 (36,76% of them were in deep surgical sites. Eighteen of the 30 patients (60% were infected with a single microorganism. Eleven patients (36,66% had a single infection episode. Microorganism were gram negative in 52 (76,47% of the infections, gram positive in 14 (20,58% of the infections, rest of the 2 (2,94% infections were due to Candidiasis. Among the possible risk factors contributing to mortality, there was a statistically significant dif- ference (p < 0,001 between the platelet counts of the mortality and surviving groups of the patients. Conclu- sion. Infections are among the preventable risk factors for mortality and morbidity after liver transplantation. Our data reveals a significant relation between trombocytopenia and mortality among the infected patients. Further studies focusing on this relation would expose the mechanisms and any possible contribution in cli- nical management of the patients. 

  13. New method for introducing nanometer flux pinning centers into single domain YBCO bulk superconductors

    Yang, W.M., E-mail: yangwm@snnu.edu.cn; Wang, Miao

    2013-10-15

    Highlights: • Single domain YBCO bulks with Bi{sub 2}O{sub 3} additions fabricated by TSIG process. • Nanoscale Y{sub 2}Ba{sub 4}CuBiOx(YBi2411) particles introduced by Bi{sub 2}O{sub 3} additions. • The YBi2411 particles are about 150 nm, can act as effective flux pinning centers. • The optimal addition of Bi{sub 2}O{sub 3} is 0.7wt% to achieve higher levitation force. • The result is helpful to improve the quality of REBCO bulk superconductors. -- Abstract: Single domain YBCO superconductors with different additions of Bi{sub 2}O{sub 3} have been fabricated by top seeded infiltration and growth process (TSIG). The effect of Bi{sub 2}O{sub 3} additions on the growth morphology, microstructure and levitation force of the YBCO bulk superconductor has been investigated. The results indicate that single domain YBCO superconductors can be fabricated with the additions of Bi{sub 2}O{sub 3} less than 2 wt%; Bi{sub 2}O{sub 3} can be reacted with Y{sub 2}BaCuO{sub 5} and liquid phase and finally form Y{sub 2}Ba{sub 4}CuBiO{sub x}(YBi2411) nanoscale particles; the size of the YBi2411 particles is about 100 nm, which can act as effective flux pinning centers. It is also found that the levitation force of single domain YBCO bulks is increasing from 13 N to 34 N and decreasing to 11 N with the increasing of Bi{sub 2}O{sub 3} addition from 0.1 wt% to 0.7 wt% and 2 wt%. This result is helpful for us to improve the physical properties of REBCO bulk superconductors.

  14. A 15 year slow-slip event on the Sunda megathrust offshore Sumatra

    Tsang, Louisa L. H.; Meltzner, Aron J.; Philibosian, Belle; Hill, Emma M.; Freymueller, Jeffrey T.; Sieh, Kerry

    2015-08-01

    In the Banyak Islands of Sumatra, coral microatoll records reveal a 15 year-long reversal of interseismic vertical displacement from subsidence to uplift between 1966 and 1981. To explain these coral observations, we test four hypotheses, including regional sea level changes and various tectonic mechanisms. Our results show that the coral observations likely reflect a 15 year-long slow-slip event (SSE) on the Sunda megathrust. This long-duration SSE exceeds the duration of previously reported SSEs and demonstrates the importance of multidecade geodetic records in illuminating the full spectrum of megathrust slip behavior at subduction zones.

  15. Impact of Changes in Perinatal Care on Neonatal Respiratory Outcome and Survival of Preterm Newborns: An Overview of 15 Years

    Filipa Flor-de-Lima

    2012-01-01

    Full Text Available Survival and outcomes for preterm infants with respiratory distress syndrome (RDS have improved over the past 30 years. We conducted a study to assess the changes in perinatal care and delivery room management and their impact on respiratory outcome of very low birth weight newborns, over the last 15 years. A comparison between two epochs was performed, the periods before and after 2005, when early nasal continuous positive airway pressure (NCPAP and Intubation-SURfactant-Extubation (INSURE were introduced in our center. Three hundred ninety-five clinical records were assessed, 198 (50.1% females, gestational age 29.1 weeks (22–36, and birth weight 1130 g (360–1498. RDS was diagnosed in 247 (62.5% newborns and exogenous surfactant was administered to 217 (54.9%. Thirty-three (8.4% developed bronchopulmonary dysplasia (BPD, and 92 (23% were deceased. With the introduction of early NCPAP and INSURE, there was a decrease on the endotracheal intubation need and invasive ventilation (P<0.0001, oxygen therapy (P=0.002, and mortality (P<0.0001. The multivariate model revealed a nonsignificant reduction in BPD between the two epochs (OR=0.86; 95% CI 0.074–9.95; P=0.9. The changes in perinatal care over the last 15 years were associated to an improvement of respiratory outcome and survival, despite a nonsignificant decrease in BPD rate.

  16. Economic Burden of Road Traffic Accidents; Report from a Single Center from South Eastern Iran

    Aliyeh Sargazi

    2016-01-01

    Full Text Available Objective: To determine the economic burden of road traffic accidents (RTAs in patients admitted to a single center in south eastern Iran. Methods: This cross-sectional study was conducted in Amir-Al-Momenin hospital of Zabol affiliated with Zabol University of Medical Sciences during a 12-month period from April 2012 to April 2013. All the RTAs patients who were admitted to our emergency department were included. The direct expenses of hospital care were recorded according to their medical charts and the accountant registration information. Data are presented according to different RTAs characteristics. Results: Overall 1155 patients were included in the current study with mean age of 36.7 ± 5.14 years among whom there were 673(58.3% men and 482 (41.7% women. The annual incidence of RTAs were calculated to be 288 per 100,000 population. The RTAs economic burden in our center was 589,448.49 USD which accounted for 10.4% of total hospital expenses during the study period. The money spend on RTAs in our center was 130 times more than gross national income per capita. Cost of each patient in road traffic was 15 times more than cost of an average patient of the hospital in other sections. Conclusion: With considerable high ratio of accidents in Zabol, proper intervention is needed for controlling and preventing RTAs in order to decrease its injuries, impact and the associated economic burden.

  17. Tobacco use among students aged 13–15 years in Greece: the GYTS project

    Papastergiou Panagiotis

    2007-01-01

    Full Text Available Abstract Background Data on the prevalence of tobacco use among teenagers in Greece are limited. We examined the prevalence of smoking among middle-school students in Greece using the Global Youth Tobacco Survey (GYTS. Methods The Global Youth Tobacco Survey was implemented in Greece during the academic year 2004 – 2005 by the University of Thessaly and the National School of Public Health. Data were collected using the GYTS self-administered anonymous questionnaire, which was distributed by specifically trained field workers to a nationally representative sample of middle-school students aged 13–15 years (through randomly selected schools and classes, randomly selected through a two-stage cluster sample design. Data processing and statistical analyses were performed at the Centers for Disease Control and Prevention (CDC. Results About one third of the students 32.1% (29.4 – 35.0 reported that they had tried tobacco in the past, while 16.2% (14.3 – 18.4 reported being current users of tobacco products. In addition, 1 in 4 of ever smokers reported that they began smoking before the age of 10 years old. Almost 1 in 5 never smokers reported being susceptible to initiate smoking in the next year and about 89.8% (88.3 – 91.1 of the respondents were exposed to environmental tobacco smoke in their homes and 94.1% (93.2 – 94.9 in public places. Finally, a strikingly high number of students 95% (89.5 – 97.7 reported that they were able to buy their own cigarettes without restrictions. Conclusion The results of the GYTS show that the prevalence of smoking in middle-school children is alarmingly high in Greece. Smoking among young people constitutes a significant problem that is destined to worsen in the absence of any comprehensive efforts focused on strict anti-smoking legislation, policies and tobacco control interventions targeting children at a young age.

  18. Examination of Spent PWR Fuel Rods After 15 Years in Dry Storage

    Virginia Power Surry Nuclear Station Pressurized Water Reactor (PWR) fuel was stored in a dry inert atmosphere Castor V/21 cask at the Idaho National Environmental and Engineering Laboratory (INEEL) for 15 years at peak cladding temperatures decreasing from about 350 to 150 deg. C. Prior to the storage, the loaded cask was subjected to extensive thermal benchmark tests. The cask was opened to examine the fuel for degradation and to determine if it was suitable for extended storage. No rod breaches had occurred and no visible degradation or crud/oxide spallation were observed. Twelve rods were removed from the center of the T11 assembly and shipped from INEEL to the Argonne-West HFEF for profilometric scans. Four of these rods were punctured to determine the fission gas release from the fuel matrix and internal pressure in the rods. Three of the four rods were cut into five segments each, then shipped to the Argonne-East AGHCF for detailed examination. The test plan calls for metallographic examination of six samples from two of the rods, microhardness and hydrogen content measurements at or near the six metallographic sample locations, tensile testing of six samples from the two rods, and thermal creep testing of eight samples from the two rods to determine the extent of residual creep life. The results from the profilometry (12 rods), gas release measurements (4 rods), metallographic examinations (2 samples from 1 rod), and microhardness and hydrogen content characterization (2 samples from 1 rod) are reported here. The tensile and creep studies are just starting and will be reported at a later date, along with the additional characterization work to be performed. Although only limited pre-storage characterization is available, a number of preliminary conclusions can be drawn based on comparison with characterization of Florida Power Turkey Point rods of a similar vintage. Based on this comparison, it appears that little or no cladding thermal creep and fission

  19. Study of the fluorescence blinking behavior of single F2 color centers in LiF crystal

    Using confocal fluorescence microscopy technique, we observed experimentally the luminescence of single F2 color centers in LiF crystal. It is disclosed that the fluorescence shows blinking behavior. It is shown that this phenomenon is caused by the F2 center reorientation occurring during the experiment. The ratio of luminescence intensities of differently oriented centers is assessed theoretically for two different experiment configurations. The calculated ratios are in fine agreement with experimental result

  20. The Relationship between Bible Reading and Attitude toward Substance Use among 13-15 Year Olds

    Francis, Leslie J.

    2002-01-01

    The relationship between Bible reading and attitude toward drug use is examined among a sample of 25,888 teenagers, 13-15 year olds, throughout England and Wales. Information about sex, age, personality, belief in God, and church attendance was also considered. The conclusion is that Bible reading makes a small but significant contribution to…

  1. Stability and Change in Counseling Psychologists' Identities, Roles, Functions, and Career Satisfaction across 15 Years

    Goodyear, Rodney K.; Murdock, Nancy; Lichtenberg, James W.; McPherson, Robert; Koetting, Kristin; Petren, Suzanne

    2008-01-01

    The authors examined changes in the profession of counseling psychology by comparing results of similar surveys of Society of Counseling Psychology (SCP) members administered 15 years apart (in 1985 and 2000). The authors found the roles and settings of SCP members were relatively stable across this period but observed that notably fewer…

  2. Five Years of Tamoxifen Continues to Benefit Women 15 Years after Treatment

    In a large randomized clinical trial, women with early-stage breast cancer who received 5 years of adjuvant treatment with tamoxifen had better outcomes up to 15 years after the start of treatment than those who received 2 years of tamoxifen therapy.

  3. Characteristics of 15-Year-Old Students Predicting Scientific Literacy Skills in Turkey

    Demir, Ergül

    2016-01-01

    Since 2003, Turkey regularly participates in PISA. According to the PISA 2012 results, 15-year-old students in Turkey performed below both OECD countries and participating countries. Defining the relations between students' characteristics and their scientific literacy skills is thought to provide deeper understanding for the nature of this…

  4. Natural course of Schizophrenic disorders : A 15-year followup of a Dutch incidence cohort

    Wiersma, D; Nienhuis, FJ; Slooff, CJ; Giel, R

    1998-01-01

    Data are presented on the 15-year natural course of schizophrenia and other nonaffective functional psychoses in a cohort of 82 first-contact cases from a circumscribed area in the Netherlands, The subjects were suffering from functional psychosis with International Classification of Diseases-Ninth

  5. The Asset-Burden Paradox of Giftedness: A 15-Year Phenomenological, Longitudinal Case Study

    Peterson, Jean Sunde

    2012-01-01

    A 15-year phenomenological case study of an exceptional female from age 15 through 30 was focused on exploring the subjective experience of development during adolescence and young adulthood, with attention to how giftedness and context interacted. The main focus became her response to trauma, which was revealed early in the study. Data, including…

  6. Children Treated for Nocturnal Enuresis: Characteristics and Trends over a 15-Year Period

    Kushnir, Jonathan; Kushnir, Baruch; Sadeh, Avi

    2013-01-01

    Background: Nocturnal Enuresis (NE) is one of the most prevalent childhood disorders and has significant negative psychosocial impact on the child and family. Objective: To assess the characteristics of children with NE and trends over a 15-year period. Methods: The study included 18,677 children [11,205 (60%) boys and 7,472 (40%) girls] referred…

  7. The prevalence of Iron Deficiency and Its Anemia in 1-5 Years Old Children and Their Mothers in Birjand City

    Azita Fesharakinia

    2014-01-01

    Background &Objective: Micronutrient deficiencies are the most common nutritional disorders in the world in which iron deficiency is the most important one. This study was done for investigating the prevalence of iron deficiency and its anemia in children and their mothers in Birjand city in 2011.Materials & Methods: 143 children of 1-5 years old who referred to the health care centers of Birjand city were chosen by multistage cluster random sampling method and both the children and mothers w...

  8. A single-stage optical load-balanced switch for data centers.

    Huang, Qirui; Yeo, Yong-Kee; Zhou, Luying

    2012-10-22

    Load balancing is an attractive technique to achieve maximum throughput and optimal resource utilization in large-scale switching systems. However current electronic load-balanced switches suffer from severe problems in implementation cost, power consumption and scaling. To overcome these problems, in this paper we propose a single-stage optical load-balanced switch architecture based on an arrayed waveguide grating router (AWGR) in conjunction with fast tunable lasers. By reuse of the fast tunable lasers, the switch achieves both functions of load balancing and switching through the AWGR. With this architecture, proof-of-concept experiments have been conducted to investigate the feasibility of the optical load-balanced switch and to examine its physical performance. Compared to three-stage load-balanced switches, the reported switch needs only half of optical devices such as tunable lasers and AWGRs, which can provide a cost-effective solution for future data centers. PMID:23187266

  9. De novo cancers following liver transplantation: a single center experience in China.

    Songfeng Yu

    Full Text Available BACKGROUND: De novo cancers are a growing problem that has become one of the leading causes of late mortality after liver transplantation. The incidences and risk factors varied among literatures and fewer concerned the Eastern population. AIMS: The aim of this study was to examine the incidence and clinical features of de novo cancers after liver transplantation in a single Chinese center. METHODS: 569 patients who received liver transplantation and survived for more than 3 months in a single Chinese center were retrospectively reviewed. RESULTS: A total of 18 de novo cancers were diagnosed in 17 recipients (13 male and 4 female after a mean of 41 ± 26 months, with an overall incidence of 3.2%, which was lower than that in Western people. Of these, 8 (3.32% cases were from 241 recipients with malignant liver diseases before transplant, while 10 (3.05% cases were from 328 recipients with benign diseases. The incidence rates were comparable, p = 0.86. Furthermore, 2 cases developed in 1 year, 5 cases in 3 years and 11 cases over 3 years. The most frequent cancers developed after liver transplantation were similar to those in the general Chinese population but had much higher incidence rates. CONCLUSIONS: Liver transplant recipients were at increased risk for developing de novo cancers. The incidence rates and pattern of de novo cancers in Chinese population are different from Western people due to racial and social factors. Pre-transplant malignant condition had no relationship to de novo cancer. Exact risk factors need further studies.

  10. The 10-year Trend of Periprocedural Complication Following Carotid Artery Stenting; Single Center Experience

    Hong, Jeong-Ho [Keimyung University Dongsan Medical Center, Department of Neurology (Korea, Republic of); Kang, Jihoon; Yeo, Min-Ju; Kim, Beom Joon; Jang, Min Uk; Bae, Hee-Joon [Seoul National University College of Medicine, Department of Neurology, Stroke Center, Seoul National University Bundang Hospital (Korea, Republic of); Kwon, O-Ki; Hwang, Gyo Jun; Oh, Chang Wan [Seoul National University Bundang Hospital, Department of Neurosurgery (Korea, Republic of); Jung, Cheolkyu [Seoul National University Bundang Hospital, Department of Radiology (Korea, Republic of); Lee, Ji Sung [Soonchunhyang University Medical Center, Biostatistical Consulting Unit (Korea, Republic of); Han, Moon-Ku, E-mail: mkhan@snu.ac.kr [Seoul National University College of Medicine, Department of Neurology, Stroke Center, Seoul National University Bundang Hospital (Korea, Republic of)

    2015-04-15

    PurposeCarotid endarterectomy and stenting are used to treat carotid stenosis, with the volume of carotid artery procedures increasing over the past decade. We investigated the 10-year trend of periprocedural complications with an increasing procedure volume of carotid stenting at a single tertiary hospital.MethodsWe collected 416 consecutive cases (384 patients) of carotid artery stenting performed for either symptomatic (231 cases, 55.5 %) or asymptomatic (185 cases, 44.5 %) internal carotid artery stenosis at a single center. Periprocedural complication was defined as any stroke, myocardial infarction, or death. Procedure-related outcome included any dissection, hemodynamic event, or periprocedural complication.ResultsThe mean age was 68.8 years (82.8 % males; range of 20–89 years); 23.9 % were older than 75 years. Before the procedure, 99.3 and 56.0 % of patients received antiplatelet and lipid-lowering medication, respectively. The overall periprocedural complication rate was 3.6 % (1.6 and 5.2 % in the asymptomatic and symptomatic group, respectively). The composite outcome of any stroke or death was 3.4 %. Periprocedural complication and procedure-related outcome showed a decremental trend with increasing procedure volume, and this trend remained after adjusting for confounders.ConclusionsOur study suggests that carotid stenting at an experienced center might reduce the periprocedural complications. Our periprocedural complication rate of carotid artery stenting may be comparable to, or somewhat lower than, that reported in other clinical trials.

  11. Continuous dynamical decoupling of a single diamond nitrogen-vacancy center spin with a mechanical resonator

    MacQuarrie, E. R.; Gosavi, T. A.; Bhave, S. A.; Fuchs, G. D.

    2015-12-01

    Inhomogeneous dephasing from uncontrolled environmental noise can limit the coherence of a quantum sensor or qubit. For solid-state spin qubits such as the nitrogen-vacancy (NV) center in diamond, a dominant source of environmental noise is magnetic field fluctuations due to nearby paramagnetic impurities and instabilities in a magnetic bias field. In this work, we use ac stress generated by a diamond mechanical resonator to engineer a dressed spin basis in which a single NV center qubit is less sensitive to its magnetic environment. For a qubit in the thermally isolated subspace of this protected basis, we prolong the dephasing time T2* from 2.7 ±0.1 to 15 ±1 μ s by dressing with a Ω /2 π =581 ±2 kHz mechanical Rabi field. Furthermore, we develop a model that quantitatively predicts the relationship between Ω and T2* in the dressed basis. Our model suggests that a combination of magnetic field fluctuations and hyperfine coupling to nearby nuclear spins limits the protected coherence time over the range of Ω accessed here. We show that amplitude noise in Ω will dominate the dephasing for larger driving fields.

  12. Sensing of single nuclear spins in random thermal motion with proximate nitrogen-vacancy centers

    Bruderer, M.; Fernández-Acebal, P.; Aurich, R.; Plenio, M. B.

    2016-03-01

    Nitrogen-vacancy (NV) centers in diamond have emerged as valuable tools for sensing and polarizing spins. Motivated by potential applications in chemistry, biology, and medicine, we show that NV-based sensors are capable of detecting single spin targets even if they undergo diffusive motion in an ambient thermal environment. Focusing on experimentally relevant diffusion regimes, we derive an effective model for the NV-target interaction, where parameters entering the model are obtained from numerical simulations of the target motion. The practicality of our approach is demonstrated by analyzing two realistic experimental scenarios: (i) time-resolved sensing of a fluorine nuclear spin bound to an N-heterocyclic carbene-ruthenium (NHC-Ru) catalyst that is immobilized on the diamond surface and (ii) detection of an electron spin label by an NV center in a nanodiamond, both attached to a vibrating chemokine receptor in thermal motion. We find in particular that the detachment of a fluorine target from the NHC-Ru carrier molecule can be monitored with a time resolution of a few seconds.

  13. Exclusion Reasons of Living Kidney Donor Candidates: A Single-Center Experience

    Ayşegül ORUÇ

    2014-05-01

    Full Text Available OBJECTIVE: Due to severe organ shortage, living kidney donors are important choices for transplantation. In Muslim countries, such as Turkey, living kidney donors are the main source of donor pool. In the literature, reasons for living donor exclusion are reported from several countries. However, there is no published study that focused on exclusion reasons of donor candidates in Turkey where living kidney transplantation rate is 73.4%. The goal of this retrospective study was to examine the exclusion reasons for donation among living kidney donor candidates at a single center in Turkey. MATERIAL and METHODS: A total 538 adults were evaluated as a living kidney donor candidate between December 1988 and January 2012. Evaluation outcome, exclusion reasons and demographic data were examined from electronic file system and immunology laboratory records. RESULTS: In this period 451 kidney transplantations (38.6% cadaveric, 61.4% living donor was performed. Overall 261 (48.5% donor candidates who underwent evaluation could not donate. We were able to find the precise cause of exclusion of 86 donors (33%. Among excluded donor candidates the most common exclusion reason was medical causes (64% such as diabetes mellitus, low glomerular filtration rate and hypertension. CONCLUSION: Our study suggests that medical causes are significant exclusion reasons for living kidney donation at our center.

  14. Narrow-band single photon emission at room temperature based on a single Nitrogen-vacancy center coupled to an all-fiber-cavity

    Albrecht, Roland; Pauly, Christoph; Mücklich, Frank; Schell, Andreas W; Engel, Philip; Schröder, Tim; Benson, Oliver; Reichel, Jakob; Becher, Christoph

    2014-01-01

    We report the realization of a device based on a single Nitrogen-vacancy (NV) center in diamond coupled to a fiber-cavity for use as single photon source (SPS). The device consists of two concave mirrors each directly fabricated on the facets of two optical fibers and a preselected nanodiamond containing a single NV center deposited onto one of these mirrors. Both, cavity in- and output are directly fiber-coupled and the emission wavelength is easily tunable by variation of the separation of the two mirrors with a piezo-electric crystal. By coupling to the cavity we achieve an increase of the spectral photon rate density by two orders of magnitude compared to free-space emission of the NV center. With this work we establish a simple all-fiber based SPS with promising prospects for the integration into photonic quantum networks.

  15. Psychiatric severity and mortality in substance abusers. A 15 year follow-up

    Fridell, Mats; Hesse, Morten

    2006-01-01

    abusers who become abstinent, mortality is often higher than in the general population. A consecutive sample of drug users admitted for detoxification was followed for 15 years. Face-to-face interviews were conducted at 5-year follow-up. At 15-year follow-up, 24% were dead. Cox proportional hazard...... mortality. Psychiatric treatment, including psychotherapy, may be more life-saving for substance abusers than drug-abuse services.......Previous research has shown that most transitions into abstinence happens in the stages of the drug career quickly after the first treatment episode. Mortality is somewhat reduced for patients who become abstinent, but remains high for patients who remain addicted. However, even among substance...

  16. Characterization of a Crystalline Silicon Photovoltaic System after 15 Years of Operation in Northern Denmark

    Spataru, Sergiu; Cernek, Petr; Sera, Dezso; Kerekes, Tamas; Teodorescu, Remus

    concerning the long term performance and degradation modes of PV systems installed in Denmark. From a global perspective of the PV system performance and reliability research, there is the initiative to develop comparative testing standards for PV modules, which are climate specific. In this this regard...... field performance degradation data and understanding of the climate/region specific failure modes of PV modules is necessary. In the present work we investigate the performance degradation of a 15 year old PV system (based on multi-crystalline silicone technology), and aim to identify the main...... parameters of the PV system that have degraded, as relative to the datasheet values and to a control module which came from the same batch, and was stored indoors during the 15 years. In addition to the degradation analysis of the main parameters of the current-voltage (I-V) characteristic curve (such as...

  17. Patch-test results in children and adolescents: systematic review of a 15-year period*

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-01-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical rel...

  18. Burkitt's Lymphoma/Leukemia in a 15-Year-Old Male

    Songrug, Tanakorn; Adler, Brent A.; Samir B. Kahwash

    2015-01-01

    We present the case of a 15-year-old male with sporadic Burkitt's lymphoma/leukemia. The patient presented with right lower quadrant abdominal pain and masses in the terminal ilium and pelvis, and was subsequently demonstrated to have involvement of the bone marrow. We discuss differential diagnoses and approach to diagnose and stage this disease. A review of the clinical, radiologic, and pathologic features of Burkitt's lymphoma/leukemia are also presented.

  19. Marine Mammal Strandings and Environmental Changes: A 15-Year Study in the St. Lawrence Ecosystem

    Marie-Hélène Truchon; Lena Measures; Vincent L'Hérault; Jean-Claude Brêthes; Galbraith, Peter S.; Michel Harvey; Sylvie Lessard; Michel Starr; Nicolas Lecomte

    2013-01-01

    Understanding the effects of climatic variability on marine mammals is challenging due to the complexity of ecological interactions. We used general linear models to analyze a 15-year database documenting marine mammal strandings (1994-2008; n = 1,193) and nine environmental parameters known to affect marine mammal survival, from regional (sea ice) to continental scales (North Atlantic Oscillation, NAO). Stranding events were more frequent during summer and fall than other seasons, and have i...

  20. Priapism associated with Niemann–Pick disease in a 15-year-old boy

    Shetty, M. V. Krishna; Kumar, M. Udaya; T K Sen

    2011-01-01

    A 15-year-old boy presented with priapism of 46 h duration. There was no known cause of priapism detected in him. During evaluation, biopsy of the lymph node and bone marrow aspiration detected patient to be having Niemann–Pick disease. He was managed with cavernous aspiration, saline irrigation, and intracavernosal phenylephrine injection. Although priapism is associated with many known diseases, about half of the cases are of idiopathic origin. We are reporting the first case of priapism as...

  1. Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update.

    Mishra, Kavita K; Squire, Sarah; Lamborn, Kathleen; Banerjee, Anuradha; Gupta, Nalin; Wara, William M; Prados, Michael D; Berger, Mitchel S; Haas-Kogan, Daphne A

    2010-10-01

    To report long-term results for children with low-grade hypothalamic/chiasmatic gliomas treated on a phase II chemotherapy protocol. Between 1984 and 1992, 33 children with hypothalamic/chiasmatic LGGs received TPDCV chemotherapy on a phase II prospective trial. Median age was 3.0 years (range 0.3-16.2). Twelve patients (36%) underwent STRs, 14 (42%) biopsy only, and seven (21%) no surgery. Twenty patients (61%) had pathologic JPAs, nine (27%) grade II gliomas, and four (12%) no surgical sampling. Median f/u for surviving patients was 15.2 years (range 5.3-20.7); 20 of the 23 surviving patients had 14 or more years of follow-up. Fifteen-year PFS and OS were 23.4 and 71.2%, respectively. Twenty-five patients progressed, of whom 13 are NED, two are AWD, and 10 have died. All children who died were diagnosed and first treated at age three or younger. Age at diagnosis was significantly associated with relapse and survival (P = 0.004 for PFS and P = 0.037 for OS). No PFS or OS benefit was seen with STR versus biopsy/no sampling (P = 0.58 for PFS, P = 0.59 for OS). For patients with JPAs and WHO grade II tumors, the 15-year PFS was 18.8 and 22.2% (P = 0.95) and 15-year OS was 73.7 and 55.6% (P = 0.17), respectively. Upfront TPDCV for children with hypothalamic/chiasmatic LGGs resulted in 15-year OS of 71.2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival. PMID:20221671

  2. Reticulitermes urbis in Bagnacavallo (Ravenna, Northern Italy): a 15-year experience in termite control

    Roberto Ferrari; Silvia Ghesini; Mario Marini

    2011-01-01

    We relate and discuss the application of a monitoring-baiting program with the IGR hexaflumuron to termite control in Bagnacavallo (Ravenna, Northern Italy), where a massive Reticulitermes urbis infestation existed in the old town. Termite control was carried out in different zones over a period of 15 years, starting from the centre of the infested area and extending towards the peripheral areas. The treatment succeeded in eliminating termites from Bagnacavallo old town, using a total of 63 g...

  3. A 15-year-old boy with snoring and molar tooth sign.

    El-Kersh, Karim; Senthilvel, Egambaram

    2015-04-01

    A 15-year-old boy presented for evaluation of snoring and sleep-disordered breathing. The parents noted that the patient snored every night and that he had episodes when he stopped breathing, ending with gasping for air. He had no history of sleep walking, night terrors, tongue biting, or seizures. The patient had two healthy siblings, but he had a history of intellectual disability and developmental delay. The patient had a history of adenotonsillectomy. PMID:25846539

  4. Hamartoma of the urinary bladder in a 15-year-old boy

    Al Shahwani, Noora; Alnaimi, Abdulla Rashid; Ammar, Adham; Al-ahdal, Esra M.

    2016-01-01

    Hamartoma of the bladder is an unusual entity described in only eleven patients to date. It may present as painless hematuria, irritative urinary tract symptoms, or inability to void or it may be diagnosed incidentally. Hamartoma of the bladder may be isolated or occur as part of a syndrome. No isolated bladder hamartoma to date has shown malignant potential. We describe here a bladder hamartoma in a 15-year-old boy. PMID:27274896

  5. Pulse Pressure magnifies the effect of COMT Val158Met on 15 Year Episodic Memory Trajectories

    Persson, Ninni; Lavebratt, Catharina; Sundström, Anna; Fischer, Håkan

    2016-01-01

    We investigated whether a physiological marker of cardiovascular health, pulse pressure (PP), and age magnified the effect of the functional COMT Val158Met (rs4680) polymorphism on 15-years cognitive trajectories [episodic memory (EM), visuospatial ability, and semantic memory] using data from 1585 non-demented adults from the Betula study. A multiple-group latent growth curve model was specified to gauge individual differences in change, and average trends therein. The allelic variants showe...

  6. Traumatic Dental Injuries Among 12-15-Year-Old-School Children in Panchkula

    Chopra, Amandeep; Lakhanpal, Manav; Rao, NC; Gupta, Nidhi; Vashisth, Shelja

    2014-01-01

    Background: Traumatic dental injury (TDI) in children and adolescents has become one of the most serious dental public health problems. Despite such a high prevalence of dental trauma, very less attention has been paid to TDI, its etiology, and prevention. Objectives: To determine the prevalence of anterior tooth traumatic dental injuries in 12-15-year-old school children of Panchkula district, India, and to find any correlation with the cause, gender, extent of overbite as well as over-jet, ...

  7. Size effects of nano-scale pinning centers on the superconducting properties of YBCO single grains

    Moutalbi, Nahed, E-mail: nahed.moutalbi@yahoo.fr [Systems and Applied Mechanics Laboratory LASMAP, Polytechnic School of Tunisia, Rue El Kawarezmi La Marsa 743, Tunis (Tunisia); Noudem, Jacques G. [CRISMAT/CNRS, UCBN/ENSICAEN, 6 Bd Maréchal Juin, 14050 Caen (France); M’chirgui, Ali [Systems and Applied Mechanics Laboratory LASMAP, Polytechnic School of Tunisia, Rue El Kawarezmi La Marsa 743, Tunis (Tunisia)

    2014-08-15

    Highlights: • Al{sub 2}O{sub 3} nano- sized inclusions were added to YBCO bulk samples in order to pin vortices. • Two batches of nano-particles with different particle size distributions were employed. • Critical current density improvement is shown to depend on size of Al{sub 2}O{sub 3} nano-inclusions. - Abstract: High pinning superconductors are the most promising materials for power engineering. Their superconducting properties are governed by the microstructure quality and the vortex pinning behavior. We report on a study of the vortex pinning in YBa{sub 2}Cu{sub 3}O{sub 7−x} (YBCO) single grain with defects induced through the addition of insulating nano-particles. In order to improve the critical current density, YBCO textured bulk superconductors were elaborated using the Top Seeded Melt Texture and Growth process with different addition amounts of Al{sub 2}O{sub 3} nano-particles. Serving as strong pinning centers, 0.05% excess of Al{sub 2}O{sub 3} causes a significant enhancement of the critical current density J{sub c} under self field and in magnetic fields at 77 K. The enhanced flux pinning achieved with the low level of alumina nano-particles endorses the effectiveness of insulating nano-inclusions to induce effectives pinning sites within the superconducting matrix. On the other side, we focused on the effect of the size of pinning centers on the critical current density. This work was carried out using two batches of alumina nano-particles characterized by two different particle size distributions with mean diameters PSD{sub 1} = 20 nm and PSD{sub 2} = 2.27 μm. The matching effects of the observed pinning force density have been compared. The obtained results have shown that the flux pinning is closely dependent on the size of the artificial pinning centers. Our results suggest that the optimization of the size of the artificial pinning centers is crucial to a much better understanding of the pinning mechanisms and therefore to insure high

  8. Formation and conversion of defect centers in low water peak single mode optical fiber induced by gamma rays irradiation

    The formation and conversion processes of defect centers in low water peak single mode optical (LWPSM) fiber irradiated with gamma rays were investigated at room temperature using electron spin resonance. Germanium electron center (GEC) and self-trapped hole center (STH) occur when the fibers are irradiated with 1 and 5 kGy cumulative doses, respectively. With the increase in irradiation doses, the GEC defect centers disappear, and new defect centers such as E' centers (Si and Ge) and nonbridge oxygen hole centers (NBOHCs) generate. The generation of GEC and STH is attributed to the electron transfer, which is completely balanced. This is the main reason that radiation-induced attenuation (RIA) of the LWPSM fiber is only 10 dB/km at communication window. The new defect centers come from the conversion of GEC and STH to E' centers and NBOHC, and the conversion processes cause bond cleavage, which is the root cause that the RIA of the LWPSM fiber significantly increases up to 180 dB/km at working window. Furthermore, the concentration of new defect centers is saturated easily even by increasing cumulative doses.

  9. Antibiotic prescribing of village doctors for children under 15 years with upper respiratory tract infections in rural China

    Zhang, Zhixia; Zhan, Xingxin; Zhou, Hongjun; Sun, Fang; Zhang, Heng; Zwarenstein, Merrick; Liu, Qian; Li, Yingxue; Yan, Weirong

    2016-01-01

    Abstract The aim of this study was to explore the knowledge, attitudes, and practices of village doctors regarding the prescribing of antibiotics for children under 15 years with upper respiratory tract infections (URTIs) in rural China. Twelve focus group discussions (FGDs) were conducted in Xianning, a prefecture-level city in rural China, during December 2014. We conducted 6 FGDs with 35 village doctors, 3 with 13 primary caregivers (11 parents), and 3 with 17 directors of township hospitals, county-level health bureaus, county-level Centers for Disease Control and Prevention, or county-level Chinese Food and Drug Administration offices. Audio records of the interviews were transcribed verbatim and analyzed using the thematic analysis approach. Participants believed that unnecessary antibiotic prescribing for children under 15 years with The occurrence of URTIs was a problem in village clinics in rural China. The discussions revealed that most of the village doctors had inadequate knowledge and misconceptions about antibiotic use, which was an important factor in the unnecessary prescribing. Village doctors and directors reported that the doctors’ fear of complications, the primary caregivers’ pressure for antibiotic treatment, and the financial considerations of patient retention were the main factors influencing the decision to prescribe antibiotics. Most of the primary caregivers insisted on antibiotics, even when the village doctors were reluctant to prescribe them, and they preferred to go to see those village doctors who prescribed antibiotics. The interviewees also gave their opinions on what would be the most effective measures for optimizing antibiotic prescriptions; these included educational/training campaigns, strict regulations on antibiotic prescription, and improved supervision. Findings emphasized the need to improve the dissemination of information and training/education, and implement legislation on the rational use of antibiotics. And it

  10. Outcomes of adult-to-adult living donor liver transplantation:a single center experience

    FENG Xi; YUAN Ding; WEI Yong-gang; LI Fu-qiang; WEN Tian-fu; ZENG Yong; ZHAO Ji-chun; WANG Wen-tao; XU Ming-qing; YANG Jia-yin; MA Yu-kui; CHEN Zhe-yu; YE Hui; YAN Lü-nan; LI Bo

    2009-01-01

    Background Since January 2002,adult-to-adult living donor liver transplantation (AALDLT) has gained increasing popularity in China in response to the shortage of cadaveric donor livers.This study presents a detailed analysis of the outcomes of AALDLT in a single center.Methods A total of 70 patients underwent AALDLT at our center between January 2002 and January 2007.Among these,67 patients received a right lobe graft without the middle hepatic vein and 3 patients received dual grafts.Three-dimensional volumetric computed tomography,magnetic resonance imaging with angiography and cholangiography were performed preoperatively.Recipient operation time,intraoperative transfusion requirement,length of intensive care unit stay,length of hospital stay,liver function tests,coagulation tests and surgical outcomes were routinely investigated throughout this study.Results All donors survived the procedure with an overall complication rate of 15.3%.Overall recipient 1-year survival and complication rates were 87.1% and 34.2%,respectively.Among the 70 cases,average graft recipient weight ratio was 0.94% (0.72%-1.43%) and average graft volume/standard liver volume ratio was 46.42% (31.74%-71.68%).All residual liver volumes exceeded 35%.Liver function and coagulation recovered rapidly within the first 7 days after transplantation.Conclusions AALDLT is a safe procedure for the donors and an effective therapy for patients with end-stage liver disease.Patient selection and timely decision-making for transplantation are essential in achieving good outcomes.With accumulation of experience in surgery and clinical management,timely feedback and proper modification,we foresee better outcomes in the future.

  11. Outcome of deceased donor renal transplantation - A single-center experience from developing country

    Himanshu V Patel

    2013-01-01

    Full Text Available Renal transplantation (RTx is considered as the best therapeutic modality for patient suffering from end-stage renal disease (ESRD. Dearth of donor kidneys is a major problem everywhere, and deceased donor renal transplantation (DDRTx is seen as at least a partial solution. Even so, DDRTx accounts for only less than 4% of RTx in India. We report our 6-year single-center experience on DDRTx vis-à-vis patient/graft survival, graft function in terms of serum creatinine (SCr, rejection episodes, and delayed graft function (DGF. Between January 2005 and March 2011, 236 DDRTx were performed. Majority of the donors were those with brain death due to road traffic/cerebrovascular accidents. The commonest recipient diseases leading to ESRD were chronic glomerulonephritis (42.8%, diabetes (12.7%, and hypertension (10.6%. Mean recipient age was 36.2 ± 14.2 years; 162 were males and 74 were females. Mean donor age was 45.3 ± 17.13 years; 144 were males and 92 were females. Mean dialysis duration pre-transplantation was 18.5 ± 2.5 months. All recipients received single-dose rabbit-anti-thymocyte globulin induction and steroids, calcinueurin inhibitor, and mycophenolate mofetil/azathioprine for maintenance immunosuppression. Delayed graft function was observed in 29.6% patients and 22% had biopsy-proven acute rejection. Over the mean follow-up of 2.18 ± 1.75 years, patient and graft survival rates were 74.57% and 86.8%, respectively, with mean SCr of 1.42 ± 0.66 mg%. DDRTx achieves acceptable graft function with patient/graft survival, encouraging the use of this approach in view of organ shortage.

  12. Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience

    Nikos Emmanouilidis

    2016-01-01

    Full Text Available Background. This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT for hepatocellular carcinoma (HCC. Methods. All 319 LT for HCC that were performed between 1975 and 2011 were included. Predictors for HCC recurrence (HCCR and survival were identified by Cox regression, Kaplan-Meier analysis, Log Rank, and χ2-tests where appropriate. Results. HCCR was the single strongest hazard for survival (exp⁡B=10.156. Hazards for HCCR were tumor staging beyond the histologic MILAN (exp⁡B=3.645, bilateral tumor spreading (exp⁡B=14.505, tumor grading beyond G2 (exp⁡B=8.668, and vascular infiltration of small or large vessels (exp⁡B=11.612, exp⁡B=18.324, resp.. Grading beyond G2 (exp⁡B=10.498 as well as small and large vascular infiltrations (exp⁡B=13.337, exp⁡B=16.737, resp. was associated with higher hazard ratios for long-term survival as compared to liver transplantation beyond histological MILAN (exp⁡B=4.533. Tumor dedifferentiation significantly correlated with vascular infiltration (χ2p=0.006 and intrahepatic tumor spreading (χ2p=0.016. Conclusion. LT enables survival from HCC. HCC dedifferentiation is associated with vascular infiltration and intrahepatic tumor spreading and is a strong hazard for HCCR and survival. Pretransplant tumor staging should include grading by biopsy, because grading is a reliable and easily accessible predictor of HCCR and survival. Detection of dedifferentiation should speed up the allocation process.

  13. Laparoscopy Versus Robotic Surgery for Colorectal Cancer: A Single-Center Initial Experience.

    Ferrara, Francesco; Piagnerelli, Riccardo; Scheiterle, Maximilian; Di Mare, Giulio; Gnoni, Pasquale; Marrelli, Daniele; Roviello, Franco

    2016-08-01

    Background Minimally invasive approach has gained interest in the treatment of patients with colorectal cancer. The purpose of this study is to analyze the differences between laparoscopy and robotics for colorectal cancer in terms of oncologic and clinical outcomes in an initial experience of a single center. Materials and Methods Clinico-pathological data of 100 patients surgically treated for colorectal cancer from March 2008 to April 2014 with laparoscopy and robotics were analyzed. The procedures were right colonic, left colonic, and rectal resections. A comparison between the laparoscopic and robotic resections was made and an analysis of the first and the last procedures in the 2 groups was performed. Results Forty-two patients underwent robotic resection and 58 underwent laparoscopic resection. The postoperative mortality was 1%. The number of harvested lymph nodes was higher in robotics. The conversion rate was 7.1% for robotics and 3.4% for laparoscopy. The operative time was lower in laparoscopy for all the procedures. No differences were found between the first and the last procedures in the 2 groups. Conclusions This initial experience has shown that robotic surgery for the treatment of colorectal adenocarcinoma is a feasible and safe procedure in terms of oncologic and clinical outcomes, although an appropriate learning curve is necessary. Further investigation is needed to demonstrate real advantages of robotics over laparoscopy. PMID:26721500

  14. Astigmatic single photon emission computed tomography imaging with a displaced center of rotation

    A filtered backprojection algorithm is developed for single photon emission computed tomography (SPECT) imaging with an astigmatic collimator having a displaced center of rotation. The astigmatic collimator has two perpendicular focal lines, one that is parallel to the axis of rotation of the gamma camera and one that is perpendicular to this axis. Using SPECT simulations of projection data from a hot rod phantom and point source arrays, it is found that a lack of incorporation of the mechanical shift in the reconstruction algorithm causes errors and artifacts in reconstructed SPECT images. The collimator and acquisition parameters in the astigmatic reconstruction formula, which include focal lengths, radius of rotation, and mechanical shifts, are often partly unknown and can be determined using the projections of a point source at various projection angles. The accurate determination of these parameters by a least squares fitting technique using projection data from numerically simulated SPECT acquisitions is studied. These studies show that the accuracy of parameter determination is improved as the distance between the point source and the axis of rotation of the gamma camera is increased. The focal length to the focal line perpendicular to the axis of rotation is determined more accurately than the focal length to the focal line parallel to this axis. copyright 1998 American Association of Physicists in Medicine

  15. Pharmacomechanical Thrombolysis for the Treatment of Thrombosed Native Arteriovenous Fistula: A Single-Center Experience

    Native arteriovenous fistula is one of the important routes for hemodialysis patients because of increased long-term survival and preservation of quality of life. We reported on a single-center experience with using pharmacomechanical thrombolysis for the treatment of thrombosed native arteriovenous fistula. This was a retrospective study of 12 hemodialysis patients (8 males and 4 females) with 14 thrombosed distal forearm Brescia-Cimino radiocephalic fistulas who were referred for pharmacomechanical thrombolytic treatment in the intervention unit of the Radiology Department, from 1 January 2010 to 30 December 2011. Demographic data, technical success rates, clinical success rates and complications were evaluated. The patency was evaluated by Kaplan-Meier analysis. The technical and clinical success was found in 12 thrombosed fistulas. Only 3 procedures had minor complications including small amounts of adjacent soft tissue hematoma. There were no procedure-related major complications. The primary patency rates at 6 and 12 months were 67% and 50%. The secondary patency rates at 6 and 12 months were 75% and 67%. Pharmacomechanical thrombolysis is a minimally invasive, effective, durable, and safe procedure for the treatment of thrombosed native arteriovenous fistula. This procedure can be considered as an alternative treatment for thrombosed dialysis fistulas

  16. Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience

    Kristoffer Watten Brudvik

    2013-01-01

    Full Text Available Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM in a 10-year period when new treatment strategies were implemented. Methods. Data from 239 consecutive patients selected for liver resection of CRLM during the period from 2002 to 2011 at a single center were used to estimate overall and disease-free survival. The results were assessed against new treatment strategies and established risk factors. Results. The 5-year cumulative overall and disease-free survivals were 46 and 24%. The overall survival was the same after reresection, independently of the number of prior resections and irrespectively of the location of the recurrent disease. The time intervals between each recurrence were similar (11 ± 1 months. Patients with high tumor load given neoadjuvant chemotherapy had comparable survival to those with less extensive disease without neoadjuvant chemotherapy. Positive resection margin or resectable extrahepatic disease did not affect overall survival. Conclusion. Our data support that one still, and perhaps to an even greater extent, should seek an aggressive therapeutic strategy to achieve resectable status for recurrent hepatic and extrahepatic metastases. The data should be viewed in the context of recent advances in the understanding of cancer biology and the metastatic process.

  17. The impact of job satisfaction on the risk of disability pension. A 15-year prospective study

    Labriola, Merete; Feveile, Helene; Christensen, Karl Bang;

    2009-01-01

    OBJECTIVES: To identify the impact of job satisfaction on the risk of disability pension. METHODS: A total of 8,338 employees were sampled from the total working population in Denmark. They were interviewed regarding age, gender, job satisfaction and health behaviour. Interview data were merged...... with national register data on granted disability pension for up to 15 years after baseline data collection. RESULTS: The study found a statistically significant association between low job satisfaction and disability pension for women when adjusted for age, smoking status and BMI. CONCLUSIONS: Based...

  18. Students (ages 6, 10, and 15 years in six countries knowledge of animals

    Patricia Patrick

    2013-04-01

    Full Text Available This article considers the knowledge students (ages 6, 10, and 15 years have of animals from a cross-cultural perspective. Students from six countries (Brazil, England, Finland, Iceland, Portugal, and the United States of America were asked to free-list as many animals as possible and state where they had seen or learned about the animals. The results were analyzed and they indicate that 1 Students are aware of animals. 2 Students are more aware of mammals as examples of animals. 3 There is a globally shared folk biological knowledge of animals. 4 Students learn about animals during sociocultural interactions. The educational implications are discussed.

  19. Youth and acne - a survey among 14- and 15-year-olds

    2005-01-01

    Acne is a condition which can give both physical and psychological scars. Young persons are vulnerable to the negative effects of acne. Our survey investigates whether the knowledge about causes and treatment of acne is satisfactory among 14- and 15-year-olds. How does acne effect their self-esteem and well-being in school? Is there a need for information and how is their help-seeking behaviour? Our survey included 304 students from 5 different schools. The response rate was 99%. ...

  20. Clear cell adenocarcinoma of the ulterine cervix in a 15 year old girl: A case report

    Cervical cancer is rare in the pediatric population. In cases of cervical cancer, adenocarcinoma is predominantly reported. Clear cell adenocarcinoma (CCAC) of the uterine cervix is a very rare tumor and accounts for only 4% of all adenocarcinomas of the uterine cervix. Risk factors and pathogenesis of this disease are not exactly revealed. The intrauterine exposure to diethylstilbestrol (DES) and associated non-steroidal estrogen during pregnancy before 18 weeks is the only known risk factor. This study reports the imaging finding of primary uterine cervical tumor in a 15-year-old girl, who was finally diagnosed with CCAC, with no maternal history of DES exposure in utero.

  1. Reticulitermes urbis in Bagnacavallo (Ravenna, Northern Italy: a 15-year experience in termite control

    Roberto Ferrari

    2011-08-01

    Full Text Available We relate and discuss the application of a monitoring-baiting program with the IGR hexaflumuron to termite control in Bagnacavallo (Ravenna, Northern Italy, where a massive Reticulitermes urbis infestation existed in the old town. Termite control was carried out in different zones over a period of 15 years, starting from the centre of the infested area and extending towards the peripheral areas. The treatment succeeded in eliminating termites from Bagnacavallo old town, using a total of 63 g of hexaflumuron.

  2. Evaluation of two stormwater infiltration trenches in central Copenhagen after 15 years of operation

    Bergman, Maria Kerstin; Hedegaard, Mathilde Jørgensen; Petersen, Mette Fjendbo;

    2011-01-01

    to see whether the reduction in performance has continued and to determine how the system performs today. Water levels in the trenches were monitored for almost 4 months, and from this period seven events were selected to analyse the infiltration rate. A comparison with similar analyses on storm...... sequences from the first 3 years of operation shows that the infiltration has decreased since the establishment of the system 15 years ago. The decrease is statistically significant (p <0.01). A clogging model was fitted to the data and predictions were made for future performance. The results show that the...

  3. Advanced separation and transmutation, long dated behavior of vitrified wastes: 15 years of scientific researches

    This report presents the results after 15 years of researches at the Cea, concerning the separation and transmutation of radioactive wastes and the conditioning and the long time storage of wastes at the surface. These researches were asked in the framework of the Bataille law. The first part devoted to the transmutation and separation of ling life radioactive elements presents the challenges, the advanced separation, the transmutation and the evaluation of the researches. The second part devoted to the long dated storage discusses the high activity wastes vitrification, the behavior of the vitrified wastes packages after thousand years, the international researches and the evaluation of the researches. (A.L.B.)

  4. Gingival recession in school kids aged 10-15 years in Udaipur, India

    Mathur Anmol

    2009-01-01

    Full Text Available Aim : The study aimed to determine the incidence of gingival recession in the mandibular central incisor region among school children aged 10-15 years in Udaipur (India. Materials and Methods : A sample of 1800 males and female kids were examined in a mobile dental unit. World Health Organisation (WHO rules and standards were followed. Result : Gingival recession, when compared, with respect to age, mean clinical crown length, anterior crowding and frenal involvement was significant (p less than 0.00 with respect to affected teeth.

  5. LEGO-based Robotics in Higher Education: 15 Years of Student Creativity

    Ethan Danahy; Eric Wang; Jay Brockman; Adam Carberry; Ben Shapiro; Rogers, Chris B.

    2014-01-01

    Our goal in this article is to reflect on the role LEGO robotics has played in college engineering education over the last 15 years, starting with the introduction of the RCX in 1998 and ending with the introduction of the EV3 in 2013. By combining a modular computer programming language with a modular building platform, LEGO Education has allowed students (of all ages) to become active leaders in their own education as they build everything from animals for a robotic zoo to robots that play ...

  6. Clear cell adenocarcinoma of the ulterine cervix in a 15 year old girl: A case report

    Choi, Seung Joon; Kim, Jee Eun; KIm, Hyung Sik; Choi, Hye Young [Dept. of Radiology, Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2013-10-15

    Cervical cancer is rare in the pediatric population. In cases of cervical cancer, adenocarcinoma is predominantly reported. Clear cell adenocarcinoma (CCAC) of the uterine cervix is a very rare tumor and accounts for only 4% of all adenocarcinomas of the uterine cervix. Risk factors and pathogenesis of this disease are not exactly revealed. The intrauterine exposure to diethylstilbestrol (DES) and associated non-steroidal estrogen during pregnancy before 18 weeks is the only known risk factor. This study reports the imaging finding of primary uterine cervical tumor in a 15-year-old girl, who was finally diagnosed with CCAC, with no maternal history of DES exposure in utero.

  7. Clinicopathological analysis of salivary gland tumors over a 15-year period

    Artur Cunha VASCONCELOS

    2016-01-01

    Full Text Available Abstract Salivary gland tumors (SGT are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group as well as anatomic location, histological type and clinical behavior of the tumor were recorded. Availability of complete information about these aspects was considered the inclusion criteria. Descriptive statistical analysis of the data was performed using the frequencies of categorical variables. Among the 2168 cases of tumors in the head and neck region, 243 (11.20% cases were diagnosed in the salivary glands, 109 of which met the inclusion criteria: 85 (78% benign tumors and 24 (22% malignant tumors. Mean patient age was 46.47 years. The female gender accounted for 56 cases (51.4% and the male gender accounted for 53 (48.3%. The major salivary glands were affected more (75.2% than the minor glands. The most frequent benign and malignant SGTs were pleomorphic adenoma (81.2% and adenoid cystic carcinoma (58.3%, respectively. In conclusion, pleomorphic adenoma and adenoid cystic carcinoma are the most frequent benign and malignant lesions, respectively. Comparing the present data with previous studies on SGTs, one may infer that some demographic characteristics and the predominance of malignant tumors vary in different geographic regions.

  8. Within-person reproducibility of red blood cell mercury over a 10- to 15-year period among women in the Nurses' Health Study II.

    Kioumourtzoglou, Marianthi-Anna; Roberts, Andrea L; Nielsen, Flemming; Tworoger, Shelley S; Grandjean, Philippe; Weisskopf, Marc G

    2016-01-01

    Most epidemiologic studies of methylmercury (MeHg) health effects rely on a single measurement of a MeHg biomarker to assess long-term exposures. Long-term reproducibility data are, therefore, needed to assess the reliability of a single measure to reflect long-term exposures. In this study, we assessed within-person reproducibility of red blood cell (RBC) mercury (Hg), a marker of methyl-mercury, over 10-15 years in a sample of 57 women. Fifty-seven women from the Nurses' Health Study II provided two blood samples 10-15-years apart (median: 12 years), which were analyzed for mercury levels in the red blood cells (B-Hg*). To characterize within-person reproducibility, we estimated correlation and intraclass correlation coefficients (r and ICC) across the two samples. Further, we compared different prediction models, including variables on fish and seafood consumption, for B-Hg* at the first sample, using leave-one-out cross-validation to assess predictive ability. Overall, we observed strong correlations over 10-15 years (r=0.69), as well as a high ICC (0.67; 95% CI: 0.49, 0.79). Fish and seafood consumption reported concurrently with the first B-Hg* sample accounted for 26.8% of the variability in that B-Hg*, giving a correlation of r=0.52. Despite decreasing B-Hg* levels over time, we observed strong correlations and high ICC estimates across B-Hg* measured 10-15 years apart, suggesting good relative within-person stability over time. Our results indicate that a single measurement of B-Hg* likely is adequate to represent long-term exposures. PMID:25492240

  9. Receptor dose and patient dose in radiographic exposures: a 15 year review

    A patient dose programme has been established locally for the last 15 years across 109 hospitals and 250 X-ray rooms in line with the National Protocol, in conjunction with a programme to look at routine performance of these rooms. Routine performance checks initially looked primarily at film density and AEC performance but with the introduction of Computerised Radiography (CR) across UK hospitals and a revision of recommended procedures in the UK, the emphasis has shifted to assessing receptor dose under AEC control. Results show a wide variation in film density in the early years indicating sub optimal performance and dose. The spread was reduced over later years. The introduction of CR has led to a variety of approaches by the CR companies, X-ray companies and local sites. Receptor doses vary widely as a result. Large variations within hospitals were also observed. The doses over the last 15 years are reviewed and compared against diagnostic reference levels and with the performance of the imaging chain. Results show that patient dose programmes and optimisation strategies were having an impact, but the introduction of CR requires renewed efforts to ensure images and doses are optimised. (author)

  10. Coronary artery occlusion after arterial switch operation in an asymptomatic 15-year-old boy.

    Saini, Ashish P; Cyran, Stephen E; Ettinger, Steven M; Pauliks, Linda B

    2016-08-16

    A 15-year-old boy with transposition of the great arteries (TGA) and neonatal arterial switch operation (ASO) presented with complete occlusion of the left main coronary artery (LMCA). Intra-operatively, an intramural left coronary artery was identified. Therefore, since age 7 years he had a series of screening exercise stress tests. At 13 years old, he had 3 to 4 mm ST segment depression in the infero-lateral leads without symptoms. This progressed to 4.2 mm inferior ST segment depression at 15 years old with normal stress echocardiogram. Sestamibi myocardial perfusion scan and cardiac magnetic resonance imaging was inconclusive. Therefore, a coronary angiogram was obtained which showed complete occlusion of the LMCA with ample collateralization from the right coronary artery system. This was later confirmed on a computed tomogram (CT) angiogram, obtained in preparation of coronary artery bypass grafting. The case illustrates the difficulty of detecting coronary artery stenosis and occlusion in young patients with rich collateralization. Coronary CT angiogram and conventional angiography were the best imaging modalities to detect coronary anomalies in this adolescent with surgically corrected TGA. Screening CT angiography may be warranted for TGA patients, particularly for those with known coronary anomalies. PMID:27574609

  11. 200-BP-1 Prototype Hanford Barrier -- 15 Years of Performance Monitoring

    Ward, Anderson L.; Draper, Kathryn E.; Link, Steven O.; Clayton, Ray E.

    2011-09-30

    Monitoring is an essential component of engineered barrier system design and operation. A composite capacitive cover, including a capillary break and an evapotranspiration (ET) barrier at the Hanford Site, is generating data that can be used to help resolve these issues. The prototype Hanford barrier was constructed over the 216-B-57 Crib in 1994 to evaluate surface-barrier constructability, construction costs, and physical and hydrologic performance at the field scale. The barrier has been routinely monitored between November 1994 and September 1998 as part of a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) treatability test of barrier performance for the 200 BP 1 Operable Unit. Since FY 1998, monitoring has focused on a more limited set of key water balance, stability, and biotic parameters. In FY 2009, data collection was focused on: (1) water-balance monitoring, consisting of precipitation, runoff, soil moisture storage, and drainage measurements with evapotranspiration calculated by difference; (2) stability monitoring, consisting of asphalt-layer-settlement, basalt-side-slope-stability, and surface-elevation measurements; (3) vegetation dynamics; and (4) animal use. September 2009 marked 15 years since the start of monitoring and the collection of performance data. This report describes the results of monitoring activities during the period October 1, 2008, through September 30, 2009, and summarizes the 15 years of performance data collected from September 1994 through September 2009.

  12. High aerosol acidity despite declining atmospheric sulfate concentrations over the past 15 years

    Weber, Rodney J.; Guo, Hongyu; Russell, Armistead G.; Nenes, Athanasios

    2016-04-01

    Particle acidity affects aerosol concentrations, chemical composition and toxicity. Sulfate is often the main acid component of aerosols, and largely determines the acidity of fine particles under 2.5 μm in diameter, PM2.5. Over the past 15 years, atmospheric sulfate concentrations in the southeastern United States have decreased by 70%, whereas ammonia concentrations have been steady. Similar trends are occurring in many regions globally. Aerosol ammonium nitrate concentrations were assumed to increase to compensate for decreasing sulfate, which would result from increasing neutrality. Here we use observed gas and aerosol composition, humidity, and temperature data collected at a rural southeastern US site in June and July 2013 (ref. ), and a thermodynamic model that predicts pH and the gas-particle equilibrium concentrations of inorganic species from the observations to show that PM2.5 at the site is acidic. pH buffering by partitioning of ammonia between the gas and particle phases produced a relatively constant particle pH of 0-2 throughout the 15 years of decreasing atmospheric sulfate concentrations, and little change in particle ammonium nitrate concentrations. We conclude that the reductions in aerosol acidity widely anticipated from sulfur reductions, and expected acidity-related health and climate benefits, are unlikely to occur until atmospheric sulfate concentrations reach near pre-anthropogenic levels.

  13. Reproducibility of a web-based FFQ for 13- to 15-year-old Danish adolescents.

    Bjerregaard, Anne A; Tetens, Inge; Olsen, Sjurdur F; Halldorsson, Thorhallur I

    2016-01-01

    FFQ are widely used in large-scale studies to assess dietary intake. To aid interpretation of diet-disease associations assessment of validity must be performed. Reproducibility is one aspect of validity focusing on the stability of repeated assessment with the same method which may also reveal problems in instrument design or participant instructions. The aim of the present study was to evaluate the reproducibility of a web-based FFQ targeting Danish adolescents within the Danish National Birth Cohort (DNBC). Data for the present study were obtained from a prospective design nested within the DNBC. Adolescents aged 13 to 15 years old (n 48, 60 % girls) completed the FFQ twice 4 weeks apart. The proportion of adolescents consistently classified into the same tertile according to amount of food intake ranged from 45 % (fish) to 77 % (vegetables), whereas classification into opposite tertiles ranged from 0 % (fruit, oils and dressing) to 15 % (beverages). Overall, no significant differences were observed in intake of food groups or nutrients between the two completions of the FFQ. Mean crude Spearman correlation for all food groups was 0·56 and mean intra-class correlation for all food groups was 0·61. In conclusion, the reproducibility of the FFQ for Danish adolescents was acceptable. The study revealed that adolescents aged 13-15 years seemed capable of recalling consistently overall dietary habits and had some difficulties estimating the frequency of consumption of regularly consumed food items. PMID:26855775

  14. Pulse Pressure magnifies the effect of COMTVal158Met on 15 Year Episodic Memory Trajectories

    Ninni ePersson

    2016-03-01

    Full Text Available We investigated whether a physiological marker of cardiovascular health, pulse pres­sure (PP, and age magnified the effect of the functional COMT Val158Met (rs4680 pol­ymor­phism on 15-year cognitive trajectories (episodic memory [EM], visuospatial ability, and se­man­tic memory using data from 1585 non-demented adults from the Betula study. A mul­tiple-group growth model was specified to gauge individual differences in change. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by sta­tistical control for PP. Further, PP mod­erated the effects of COMT on 15-year EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (dia­betes, stroke, and hypertension, and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in nor­mal cognitive aging, as the addition thereof may even place healthy individuals at greater risk for memory decline.

  15. Pulse Pressure Magnifies the Effect of COMT Val(158)Met on 15 Years Episodic Memory Trajectories.

    Persson, Ninni; Lavebratt, Catharina; Sundström, Anna; Fischer, Håkan

    2016-01-01

    We investigated whether a physiological marker of cardiovascular health, pulse pressure (PP), and age magnified the effect of the functional COMT Val(158)Met (rs4680) polymorphism on 15-years cognitive trajectories [episodic memory (EM), visuospatial ability, and semantic memory] using data from 1585 non-demented adults from the Betula study. A multiple-group latent growth curve model was specified to gauge individual differences in change, and average trends therein. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val(158)Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by statistical control for PP. Further, PP moderated the effects of COMT on 15-years EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (diabetes, stroke, and hypertension), and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in normal cognitive aging, as the addition thereof may place healthy individuals at greater risk for memory decline. PMID:26973509

  16. Pulse Pressure Magnifies the Effect of COMT Val158Met on 15 Years Episodic Memory Trajectories

    Persson, Ninni; Lavebratt, Catharina; Sundström, Anna; Fischer, Håkan

    2016-01-01

    We investigated whether a physiological marker of cardiovascular health, pulse pressure (PP), and age magnified the effect of the functional COMT Val158Met (rs4680) polymorphism on 15-years cognitive trajectories [episodic memory (EM), visuospatial ability, and semantic memory] using data from 1585 non-demented adults from the Betula study. A multiple-group latent growth curve model was specified to gauge individual differences in change, and average trends therein. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by statistical control for PP. Further, PP moderated the effects of COMT on 15-years EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (diabetes, stroke, and hypertension), and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in normal cognitive aging, as the addition thereof may place healthy individuals at greater risk for memory decline. PMID:26973509

  17. Intensity modulated radiation therapy (IMRT) for sinonasal tumors: a single center long-term clinical analysis

    Radiotherapy has a central role in the treatment of sinonasal malignancies, either as postoperative or as primary therapy. To study the efficacy and safety of intensity modulated radiotherapy (IMRT) for sinonasal tumors a single center retrospective evaluation focusing on survival and therapy related toxicity was performed. One hundred twenty two patients with primary (n = 82) or recurrent (n = 40) malignant sinonasal tumors were treated with intensity modulated radiotherapy between 1999 and 2009 at the University Clinic of Heidelberg and the German Cancer Research Center and retrospectively analyzed. Most patients had adenoid cystic carcinomas (n = 47) or squamous cell carcinoma (n = 26). 99 patients received postoperative radiotherapy. The median total dose was 64 Gy in conventional fractionation (1.8–2 Gy). Overall survival (OS), progression free survival (PFS) and local recurrence free survival (LRFS) rates were calculated using the Kaplan-Meier method. The log-rank test and Fishers Exact test were applied for univariate analysis, Cox-regression was used for multivariate analysis. Median follow up was 36 months. 1-, 3- and 5-year estimated overall survival rates were 90, 70 and 54 % respectively. Median progression free survival and local recurrence free survival was 45 and 63 months respectively. Progression free survival and local recurrence free survival at 1, 3 and 5 years were 76, 57 and 47, and 79, 60 and 51 % respectively. 19 patients (15.5 %) were diagnosed with distant metastases. Univariate analysis revealed significantly improved OS and LRFS for treatment of tumors after primary diagnosis, first series of irradiation and radiation dose ≥60 Gy. Multivariate analysis revealed only treatment in primary situation as an independent prognostic factor for OS and LRFS. Acute CTC grade III mucositis was seen in 5 patients (4.1 %) and CTC grade II dysgeusia in 19 patients (15.6 %). Dysgeusia, dysosmia and ocular toxicity were the most common late adverse

  18. Long-term effects and colectomy rates in ulcerative colitis patients treated with infliximab: A Danish single center experience

    Teisner, A.S.; Ainsworth, M.A.; Brynskov, J.

    2010-01-01

    provide further data on the long-term effect of IFX for acute, severe and chronic, refractory UC in unselected patients treated at a single center. Material and Methods. A retrospective analysis of all patients (n = 52) treated with IFX for UC before February 2009 was performed. The material comprised 19...

  19. A Single-Center, Adult Chronic Intestinal Failure Cohort Analyzed According to the ESPEN-Endorsed Recommendations, Definitions, and Classifications

    Brandt, Christopher Filtenborg; Tribler, Siri; Hvistendahl, Mark; Staun, Michael; Brøbech, Per; Jeppesen, Palle Bekker

    2016-01-01

    BACKGROUND/AIMS: The objective of this study was to describe a clinically well-defined, single-center, intestinal failure (IF) cohort based on a template of definitions and classifications endorsed by the European Society for Clinical Nutrition and Metabolism (ESPEN). METHODS: A cross...

  20. The effect of aqueous Elaeagnus angustifolia extract on acute non-inflammatory diarrhea in 1-5 year old children

    Khoshdel Abofazl

    2014-01-01

    Full Text Available Introduction: Acute diarrhea is one of the most important causes of global childhood mortality and morbidity. The most common complication of acute diarrhea is dehydration. The aim of this study was to evaluate the use of aqueous Elaeagnus angustifolia extract in controlling non-inflammatory diarrhea in a hospital setting. Methods: In this case–controlled randomized double blind clinical trial 80 children in age range of 1-5 years were admitted in pediatric ward with diagnosis of non-inflammatory diarrhea. The patients were randomly divided into two equal groups of 40 cases. The subject in the first group received aqueous Elaeagnus angustifolia extract, 1.2 ml/Kg single dose for 4 days duration and the second group (control group 1.2 cm/Kg distilled water single dose for 4 days duration. Data analysis were performed by Chi-square and t-tests, using SPSS software. Results: The groups were similar regarding gender, mean age, and frequency, and consistency of defecation (p> 0.05. Although the children seemed better in regard to frequency and consistency of defecation, however the results showed that aqueous extract of Elaeagnus angustifolia was not significantly effective in the treatment of non-inflammatory diarrhea. Conclusion: The results of this study demonstrated that the use of aqueous extract of Elaeagnus angustifolia was not effective in the treatment of non-inflammatory diarrhea in children.

  1. Axial lumbar interbody fusion: a 6-year single-center experience

    Zeilstra DJ

    2013-08-01

    Full Text Available Dick J Zeilstra,1 Larry E Miller,2,3 Jon E Block3 1Bergman Clinics, Naarden and NedSpine, Ede, The Netherlands; 2Miller Scientific Consulting, Inc, Arden, NC, USA; 3The Jon Block Group, San Francisco, CA, USA Introduction: The aim of this study is to report our 6-year single-center experience with L5–S1 axial lumbar interbody fusion (AxiaLIF. Methods: A total of 131 patients with symptomatic degenerative disc disease refractory to nonsurgical treatment were treated with AxiaLIF at L5–S1, and were followed for a minimum of 1 year (mean: 21 months. Main outcomes included back and leg pain severity, Oswestry Disability Index score, working status, analgesic medication use, patient satisfaction, and complications. Computed tomography was used to determine postoperative fusion status. Results: No intraoperative complications, including vascular, neural, urologic, or bowel injuries, were reported. Back and leg pain severity decreased by 51% and 42%, respectively, during the follow-up period (both P < 0.001. Back function scores improved 50% compared to baseline. Clinical success, defined as improvement ≥30%, was 67% for back pain severity, 65% for leg pain severity, and 71% for back function. The employment rate increased from 47% before surgery to 64% at final follow-up (P < 0.001. Less than one in four patients regularly used analgesic medications postsurgery. Patient satisfaction with the AxiaLIF procedure was 83%. The fusion rate was 87.8% at final follow-up. During follow-up, 17 (13.0% patients underwent 18 reoperations on the lumbar spine, including pedicle screw fixation (n = 10, total disc replacement of an uninvolved level (n = 3, facet screw fixation (n = 3, facet screw removal (n = 1, and interbody fusion at L4–L5 (n = 1. Eight (6.1% reoperations were at the index level. Conclusion: Single-level AxiaLIF is a safe and effective means to achieve lumbosacral fusion in patients with symptomatic degenerative disc disease. Keywords: Axia

  2. Treatment of intracranial aneurysms by flow diverter devices: Long-term results from a single center

    Briganti, Francesco, E-mail: frabriga@unina.it [Unit of Interventional Neuroradiology, Department of Advanced Biomedical Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Napoli, Manuela, E-mail: napoli.manuela@gmail.com [Department of Advanced Biomedical Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Leone, Giuseppe, E-mail: g.leonemd@gmail.com [Department of Advanced Biomedical Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Marseglia, Mariano, E-mail: mariano-marseglia@libero.it [Department of Advanced Biomedical Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Mariniello, Giuseppe, E-mail: giuseppe.mariniello@unina.it [Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Caranci, Ferdinando, E-mail: ferdinando.caranci@unina.it [Department of Advanced Biomedical Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy); Tortora, Fabio, E-mail: fabiotor@libero.it [Chair of Neuroradiology, “Magrassi Lanzara” Clinical-Surgical Department, Second University of Naples, Viale Colli Aminei 21, 80131 Naples (Italy); Maiuri, Francesco, E-mail: frmaiuri@unina.it [Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, “Federico II” University, Via S.Pansini 5., 80131 Naples (Italy)

    2014-09-15

    Highlights: • We report the long-term results (2–4 years) with Flow Diverter Devices (FDD) from a single-center. • We recommend the use of FDD for large-neck aneurysms of the ICA syphon. • We think that more sophisticate FDD will reduce the incidence of technical adverse events. - Abstract: Objectives: Flow-Diverter Devices (FDD) are a new generation stents designed for the treatment of the intracranial aneurysms. This article reports the long-term results (2–4 years) of this treatment from a single-center. Methods: From November 2008 to January 2012, 35 patients (29 females and 6 males; mean age 53.9 y) with 39 intracranial aneurysms were treated by FDD. Five patients (14.3%) had ruptured aneurysms and 30 (85.7%) had no previous hemorrhage. The procedures were performed in 5 patients (14.3%) with SILK and in 30 (85.7%) with PED. In 3 patients FDDs were used as a second treatment after failure of previous coiling (2 cases) or stenting (one case). The 39 aneurysms were in supraclinoid ICA in 26 (66.7%), cavernous ICA in 2 (5.1%), PCoA in 4 (10.2%), MCA in 5 (12.9%), SCA in 1 (2.6%) and PICA in 1 (2.6%). The aneurysms were small (<10 mm) in 32 cases (82%), large (11–25 mm) in 6 (15.3%) and giant in 1 (2.6%). The occlusion rate according to the aneurysm location, size and neck and the complications were evaluated. Results: Peri-procedural complications included transient dysarthria (2 patients), vasospasm with acute intra-stent aggregation (one), microwire rupture (one) and failure of the stent opening (one). The follow-up was made between 24 and 62 months (mean 41 months); clinical examination and CTA were performed at 1, 3, 6 and 12 months after the procedure. The complete occlusion was confirmed by CTA and DSA. MRI with angiographic-studies was taken every year. Complete occlusion was obtained in 35 aneurysms (92.1%) and subtotal in 3 (7.9%). Complete occlusion occurred at 3 months in 24 cases (68.6%), within 3 and 6 months in 9 (25.7%). The rate and

  3. Treatment of intracranial aneurysms by flow diverter devices: Long-term results from a single center

    Highlights: • We report the long-term results (2–4 years) with Flow Diverter Devices (FDD) from a single-center. • We recommend the use of FDD for large-neck aneurysms of the ICA syphon. • We think that more sophisticate FDD will reduce the incidence of technical adverse events. - Abstract: Objectives: Flow-Diverter Devices (FDD) are a new generation stents designed for the treatment of the intracranial aneurysms. This article reports the long-term results (2–4 years) of this treatment from a single-center. Methods: From November 2008 to January 2012, 35 patients (29 females and 6 males; mean age 53.9 y) with 39 intracranial aneurysms were treated by FDD. Five patients (14.3%) had ruptured aneurysms and 30 (85.7%) had no previous hemorrhage. The procedures were performed in 5 patients (14.3%) with SILK and in 30 (85.7%) with PED. In 3 patients FDDs were used as a second treatment after failure of previous coiling (2 cases) or stenting (one case). The 39 aneurysms were in supraclinoid ICA in 26 (66.7%), cavernous ICA in 2 (5.1%), PCoA in 4 (10.2%), MCA in 5 (12.9%), SCA in 1 (2.6%) and PICA in 1 (2.6%). The aneurysms were small (<10 mm) in 32 cases (82%), large (11–25 mm) in 6 (15.3%) and giant in 1 (2.6%). The occlusion rate according to the aneurysm location, size and neck and the complications were evaluated. Results: Peri-procedural complications included transient dysarthria (2 patients), vasospasm with acute intra-stent aggregation (one), microwire rupture (one) and failure of the stent opening (one). The follow-up was made between 24 and 62 months (mean 41 months); clinical examination and CTA were performed at 1, 3, 6 and 12 months after the procedure. The complete occlusion was confirmed by CTA and DSA. MRI with angiographic-studies was taken every year. Complete occlusion was obtained in 35 aneurysms (92.1%) and subtotal in 3 (7.9%). Complete occlusion occurred at 3 months in 24 cases (68.6%), within 3 and 6 months in 9 (25.7%). The rate and

  4. A 5-year retrospective analysis of Necrotizing fasciitis: A single center experiences

    Kiralj Aleksandar I

    2015-01-01

    Full Text Available Background/Aim. Necrotizing fasciitis (NF is usually an acute infection of superficial fascia with rapid progression in around soft tissue. If not promptly recognized and aggressively treated NF usualy leads to sepsis and multiorgan failure with fatal outcome, thus early diagnosis and prompt surgical treatment are crucial for healing of these patients. The aim of this article was to evaluate the clinical presentation of all patients with acute NF diagnosed and treated in surgical clinics of Clinical Center of Vojvodina, Novi Sad, Serbia. Methods. The medical records of patients treated for acute NF localized on a different parts of the body in Clinical Center of Vojvodina, Novi Sad, Serbia, during a 5- year period (from January 2008 to December 2012 were retrospectively evaluated. This study enrolled patients admitted via Emergency Center of Vojvodina with the diagnosis of acute NF either as the primary diagnosis or with the diagnosis at discharge after surgical treatment. Results. During a 5-year period there were 216 patients with final diagnosis of acute NF. Most of our patients (140 - 64.81% were admitted with the initial diagnosis of cellulitis, abscesses, phlegmons or sepsis. Unfortunately, the clinical symptoms of acute NF were atypical at time of initial examination. Pain and swelling of the affected localization were the most presented bias of symptoms (183 - 84.72%. The majority of our patients were male (164 - 75.92%. Among the 216 patients, the most common pre-existing single factor was drug abuse (39 - 18.05%, followed by obesity (38 - 17.59% and diabetes mellitus (31 - 14.35%. Trauma was most common etiological factor (22 - 10.8% in infected wounds, followed by abdominal (15 - 6.94% and orthopedic (11 - 5.09% surgical intervention. In the present study idiopathic acute NF was diagnosed in 22 (10.18% patients and more than one etiological factor were diagnosed in 20 (9.25% patients. The majority of our patients had type I acute NF

  5. Congenital bronchopulmonary malformations: A single-center experience and a review of literature

    Kumar Basant

    2008-01-01

    Full Text Available Purpose: To present a single-center experience with 25 cases of bronchopulmonary malformations and the review the literature. Materials and Methods: We conducted a retrospective analysis of the medical records of patients with congenital bronchopulmonary malformations who were operated between July 1997 and July 2007 in our institute; we examined the modes of presentations, management, and outcome. Outcome of all patients was assessed over a short follow-up period (average 1.8 months. Results: Out of 25 patients, 18 (72% were male and 7 (28% were female. Age of patients ranged from 1 day to 11 years. The histopathological diagnosis was congenital cystic adenomatoid malformations [CCAM; n = 14 (56%], congenital lobar emphysema [CLE; n = 5 (20%], pulmonary sequestrations [PS; n = 3 (12%], and bronchogenic cysts [BC; n = 3 (12%]. Antenatal diagnosis was available in only 2 (8% patients. The common presenting symptoms were respiratory distress and chest infections. Lobectomy was the procedure of choice . Mortality was 16% (n = 4; M: F = 3: 1. Two patients died because of overwhelming sepsis, one from compromised cardiac function, and one from aspiration which might possibly have been prevented. Conclusion: Patients with progressive respiratory distress due to these anomalies may require urgent surgical intervention regardless of age. The surgical outcome is favorable, with manageable complications. Plain x-ray chest and CT of thorax are usually sufficient for diagnosis and planning of treatment. Pathological diagnosis may differ from the imaging diagnosis. Mortality is found to be more in neonates. Apart from initial stabilization, resection of lesion and careful postoperative care is necessary to reduce mortality and morbidity.

  6. Mechanical Revascularization for Acute Ischemic Stroke: A Single-Center, Retrospective Analysis

    Jeromel, Miran, E-mail: miran.jeromel@gmail.com; Milosevic, Z. V., E-mail: zoran.milosevic@guest.arnes.si; Kocijancic, I. J., E-mail: igor.kocijancic@gmail.com; Lovric, D., E-mail: dimitrijlavric@yahoo.com [University Medical Centre Ljubljana, Clinical Institute of Radiology, Department for Diagnostic and Interventional Neuroradiology (Slovenia); Svigelj, V., E-mail: viktor.svigelj@gmail.com; Zvan, B., E-mail: bojana.zvan@guest.arnes.si [University Medical Centre Ljubljana, Division Vascular and Intensive Neurology, Department of Neurology (Slovenia)

    2013-04-15

    BackgroundEndovascular mechanical revascularization (thrombectomy) is an increasingly used method for intracranial large vessel recanalization in acute stroke. The purpose of the study was to analyze the recanalization rate, clinical outcome, and complication rate in our stroke patients treated with mechanical revascularization. A total of 57 patients with large vessel stroke (within 3 h for anterior and 12 h for posterior circulation) were treated with mechanical revascularization at a single center during 24 months. The primary goal of endovascular treatment using different mechanical devices was recanalization of the occluded vessel. Recanalization rate (reported as thrombolysis in cerebral infarction [TICI] score), clinical outcome (reported as National Institutes of Health Stroke Scale [NIHSS] score and modified Rankin scale [mRS] score), as well as periprocedural complications were analyzed. The mean age of the patients was 63.1 {+-} 12.9 years, with baseline median NIHSS score of 14 (interquartile range, 9.5-19). Successful recanalization (TICI 2b or 3) was achieved in 41 (72 %) patients. Twenty patients (35 %) presented with favorable outcome (mRS {<=}2) 30 days after stroke. Overall, significant neurological improvement ({>=}4 NIHSS point reduction) occurred in 36 (63 %) patients. A clinically significant procedure-related adverse events (vessel disruption, peri/postprocedural intracranial bleeding) defined with decline in NIHSS of {>=}4 or death occurred in three (5 %) patients. The study showed a high recanalization rate with improved clinical outcome and a low rate of periprocedural complications in our stroke patients treated with mechanical revascularization. Therefore, we could conclude that endovascular revascularization (primary or in combination with a bridging thrombolysis) was an effective and safe procedure for intracranial large vessel recanalization in acute stroke.

  7. Chromogranin A as Serum Marker for Gastroenteropancreatic Neuroendocrine Tumors: A Single Center Experience and Literature Review

    Nölting, Svenja; Kuttner, Axel [Department of Internal Medicine II, Campus Grosshadern, University-Hospital of the Ludwig-Maximilians-University of Munich, Munich 81377 (Germany); Lauseker, Michael [Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich 81377 (Germany); Vogeser, Michael [Department of Clinical Chemistry, Campus Grosshadern, University-Hospital of the Ludwig-Maximilian-University of Munich, Munich 81377 (Germany); Haug, Alexander [Clinic of Nuclear Medicine, Campus Grosshadern, University-Hospital of the Ludwig-Maximilian-University of Munich, Munich 81377 (Germany); Herrmann, Karin A. [Institute of Radiology, Campus Grosshadern, University-Hospital of the Ludwig-Maximilian-University of Munich, Munich 81377 (Germany); Hoffmann, Johannes N. [Department of Surgery, Campus Grosshadern, University-Hospital of the Ludwig-Maximilians-University of Munich, Munich 81377 (Germany); Spitzweg, Christine; Göke, Burkhard; Auernhammer, Christoph J., E-mail: christoph.auernhammer@med.uni-muenchen.de [Department of Internal Medicine II, Campus Grosshadern, University-Hospital of the Ludwig-Maximilians-University of Munich, Munich 81377 (Germany)

    2012-02-15

    The aim of this study was to assess the clinical sensitivities of the tumor markers chromogranin A (CgA), urinary 5-hydroxyindoleacetic acid (5-HIAA) and alkaline phosphatase (AP) in neuroendocrine tumors (NETs) of the GastroEnteroPancreatic-(GEP-) system depending on tumor primary location and metastatic spread. In a retrospective single-center series, sensitivities were evaluated in serum samples from 110 patients with midgut (n = 62) and pancreatic (n = 48) NETs. CgA levels were analyzed by a commercially-available immunoradiometric assay (CIS-bio) during routine follow-up in the years 2000–2009. CgA showed a higher sensitivity for midgut (68%) than pancreatic (54%) NETs. A higher CgA sensitivity and significantly higher median CgA values were found in patients with liver metastases than in those without, and in patients with hepatic and additionally extra-hepatic metastases than in those with hepatic and nodal metastases alone, respectively. We found an overall sensitivity for elevated 5HIAA excretion of 69% for midgut NETs and a significant correlation between median CgA and 5-HIAA values. The sensitivity of AP and the correlations of AP/CgA-data-pairs were low in both midgut and pancreatic NETs, although highest for metastatic pancreatic NETs. The sensitivity of CgA measurement depends on the NET primary location and spread of disease. 5-HIAA and CgA showed comparable sensitivity in midgut NETs, while AP does not seem to be useful as a tumor marker in GEP-NETs.

  8. Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study.

    Wheler, Jennifer J; Janku, Filip; Naing, Aung; Li, Yali; Stephen, Bettzy; Zinner, Ralph; Subbiah, Vivek; Fu, Siqing; Karp, Daniel; Falchook, Gerald S; Tsimberidou, Apostolia M; Piha-Paul, Sarina; Anderson, Roosevelt; Ke, Danxia; Miller, Vincent; Yelensky, Roman; Lee, J Jack; Hong, David S; Kurzrock, Razelle

    2016-07-01

    Innovative molecular diagnostics deployed in the clinic enable new ways to stratify patients into appropriate treatment regimens. These approaches may resolve a major challenge for early-phase clinical trials, which is to recruit patients who, while having failed previous treatments, may nevertheless respond to molecularly targeted drugs. We report the findings of a prospective, single-center study conducted in patients with diverse refractory cancers who underwent comprehensive genomic profiling (CGP; next-generation sequencing, 236 genes). Of the 500 patients enrolled, 188 (37.6%) received either matched (N = 122/188, 65%) or unmatched therapy (N = 66/188, 35%). The most common reasons that patients were not evaluable for treatment included insufficient tissue, death, or hospice transfer. The median number of molecular alterations per patient was five (range, 1-14); median number of prior therapies, four. The most common diagnoses were ovarian cancer (18%), breast cancer (16%), sarcoma (13%), and renal cancer (7%). Of the 339 successfully profiled patients, 317 (93.5%) had at least one potentially actionable alteration. By calculating matching scores, based on the number of drug matches and genomic aberrations per patient, we found that high scores were independently associated with a greater frequency of stable disease ≥6 months/partial/complete remission [22% (high scores) vs. 9% (low scores), P = 0.024], longer time-to-treatment failure [hazard ratio (HR) = 0.52; 95% confidence interval (CI) = 0.36-0.74; P = 0.0003], and survival (HR = 0.65; 95% CI = 0.43-1.0; P = 0.05). Collectively, this study offers a clinical proof of concept for the utility of CGP in assigning therapy to patients with refractory malignancies, especially in those patients with multiple genomic aberrations for whom combination therapies could be implemented. Cancer Res; 76(13); 3690-701. ©2016 AACR. PMID:27197177

  9. Occult Hepatitis C Virus Infection in Haemodialysis Unit: A Single-center Experience

    Abdel Hamid A. Serwah1, Waleed S. Mohamed1, Mohamed Serwah1, Awateif Edreis2, Ahmad El Zaydi3

    2014-07-01

    Full Text Available Background & Aims: Detection of hepatitis C virus RNA in peripheral blood mononuclear cells (PBMC and/or hepatocytes in the absence of HCV RNA in serum, designated as ‘occult HCV infection’, has been a matter of controversy in the recent years. Occult hepatitis C virus (HCV infection has not been investigated in haemodialysis patients. We investigated for the first time the prevalence of occult HCV infection in large cohorts of chronic hemodialysis (CHD patients in a single heamodialysis center at Al-Taif, KSA. Methods: We enrolled 84 CHD patients, whose sera are negative for HCV markers. HCV RNA was tested in PBMC using a sensitive commercial real time assay. In this study, real-time PCR was used to test for the presence of genomic HCV-RNA in peripheral blood mononuclear cells of all of these patients. For comparison, 20 patients on HD with evidence of chronic hepatitis C virus infection were included as a control group. Results: In CHD patients, occult HCV infection, determined by the presence of genomic HCV-RNA in peripheral blood mononuclear cells (PBMNCs, was found in 13.4 % of the patients; 83 % of these patients had ongoing HCV replication, indicated by the presence of HCV-RNA. Patients with occult HCV infection had spent a significantly longer time on heamodialysis and had significantly higher mean alanine aminotransferase levels during the 3 months before study entry. Compared to CHCV patients, those with occult HCV have less elevated bilirubin, AST and ALT. Conclusions: The prevalence of occult HCV infection was moderate in our CHD patients, and it did not appear to be clinically relevant. Further studies in other geographic populations with high HCV endemicity are required to clarify the significance of occult HCV infection in these patient groups. Abbreviations HCV, Hepatitis C Virus ; antibody against HCV; PBMC, peripheral blood mononuclear cells; rRT-PCR, real time reverse transcriptase polymerase chain reaction; CHD, chronic

  10. Living Related Donor Kidney Transplantation in Libya: A Single Center Experience

    Elusta Ahmed

    2008-01-01

    Full Text Available The aim of this study is to report the experience from a single center in Libya, on the prevailing live-related kidney transplantation program. The results of three years work on kidney transplantation at the Tripoli Central Hospital (National Organ Transplant Program in Libya were evaluated. The transplant program was launched on 17 th August, 2004 and 135 patients have been transplanted since then till 17 th August, 2007. All donors and recipients were screened thoroughly prior to transplant and monitored closely in the post-transplant period. Our immuno-suppressive protocol was cyclosporine-based. Among the 135 accepted pairs, donors and reci-pients were genetically-related in 133 cases (98.5% and emotionally-related in two others. The mean donor age was 37 ± 9.5 years (range 18-56 years and recipient age 37 ± 13.6 years (range 7-67 years. There were 95 males (70.4% and 40 females (29.6% among the recipients while among the donors, there were 102 males (75.6% and 33 females (24.4%. Delayed graft function was seen in three patients (2.2%, acute rejection in six (4.4%, post-transplant urinary tract infection in six (4.4%, pneumonia in three (2.2%, ureteric kink in two (1.5% and urine leak in four (3.0%. Graft survival at 36 months was 93.3% while patient survival at the same period was 96.3%. This report indicates that the results of our transplant program are good and comparable with other international programs.

  11. Percutaneous CT-guided radiofrequency ablation of solitary small renal masses. A single center experience

    Pieper, C.C.; Fischer, S.; Strunk, H.; Meyer, C.; Thomas, D.; Willinek, W.A.; Schild, H. [Univ. Bonn (Germany). Dept. of Radiology; Hauser, S. [Univ. Bonn (Germany). Dept. of Urology; Nadal, J. [Univ. Bonn (Germany). Inst. for Medical Biometry; Wilhelm, K. [Johanniter Hospital Bonn (Germany). Dept. of Radiology

    2015-07-15

    To analyze the outcome of patients undergoing percutaneous CT-guided radiofrequency ablation (RFA) of small renal masses (SRM) at a single center during a ten-year time period. Patient records of renal RFAs (07/2003 - 11/2013) were reviewed. Indications were SRM suspicious of malignancy on imaging and one of the following: severe comorbidity; old age; solitary kidney; impaired renal function; patient wish. Biopsy was performed at the time of RFA. Patients were excluded if no follow-up was available. Patient and procedural characteristics were recorded. Survival rates were calculated using the Kaplan-Meier's method and compared with log-rank or cox tests. 38 patients (16 females, mean age 70.0 years [range 52 - 87]) presenting with a solitary SRM were included in the study. Biopsy showed malignancy in 29 patients; 9 had benign tumors. 26 patients suffered from cardiovascular, respiratory or hepatic comorbidities. Technical success (complete ablation on first follow-up) was achieved in 95 % of cases. Two major complications (bowel perforation; hematothorax) occurred. The 3- and 7-year overall survival (OS) [any cause] rates were 73.4 ± 0.8 % and 50.3 ± 1.0 %, respectively (mean follow-up 54.6 months, range 1 - 127). 4 recurrences and 2 metastases were observed. The presence of comorbidities was the only independent predictor of OS. There was no difference in survival between patients with benign and malignant tumors. RFA of SRM is successful in a large percentage of cases with a low complication rate and durable local control. As RFA is typically performed in multimorbid patients, overall survival seems to depend primarily on comorbidities rather than cancer progression.

  12. Thirty-day outcome of carotid artery stenting in Chinese patients: a single-center experience

    JIAO Li-qun; SONG Gang; LI Shen-mao; MIAO Zhong-rong; ZHU Feng-shui; JI Xun-ming; YIN Guo-yang

    2013-01-01

    Background Carotid artery stenting (CAS) as a competing treatment modality has had to adhere to limits to gain widespread acceptance in some studies.This study analyzed the clinical data of 1700 consecutive patients after CAS to retrospectively evaluate the 30-day outcome of CAS for internal carotid artery stenosis in a Chinese population.Methods Medical records of 1700 patients who underwent CAS at Xuanwu Hospital affiliated to Capital Medical University between January 2001 and August 2012 were reviewed.Postoperative 30-day complication rates were analyzed and compared with those of other studies.Univariate and multivariate Logistic regression analyses were used to identify factors associated with perioperation myocardial infarction (MI),stroke,and death.Results The overall 30-day rate of MI,stroke,and death after CAS was 2.53%.In univariate analysis,patients who were symptomatic,had a neurological deficit (modified Rankin score (mRS) ≥3; P=0.001),and who were not taking statins experienced a significantly increased rate of MI,stroke,and death (P=-0.017).In multivariate Logistic regression analysis,the presence of symptoms (odds ratio (OR)=2.485; 95% confidence interval (CI)=1.267-4.876; P=0.008) and a neurological deficit (mRS ≥3) (OR=3.025; 95% CI=1.353-6.763; P=0.007) were independent risk factors for perioperative MI,stroke,and death.Conclusions According to this single-center experience,CAS may effectively prevent and treat carotid artery stenosis that would otherwise lead to stroke.Being symptomatic and having a neurological deficit (mRS ≥3) increased the risk of perioperative MI,stroke,and death.

  13. Allogeneic hematopoietic cell transplantation in patients with myelofibrosis: A single center experience.

    Schmohl, Joerg U; Groh, Christiane; Faul, Christoph; Vogel, Wichard; Möhle, Robert; Wirths, Stefan; Schneidawind, Dominik; Kanz, Lothar; Bethge, Wolfgang A

    2016-05-01

    Myelofibrosis (MF) is a rare disease responsible for an increasing ineffective hematopoesis by a progressive fibrosing process in the bone marrow. The only curative treatment option is allogeneic hematopoietic cell transplantation (HCT). In this single-center analysis, we evaluated retrospectively 54 consecutive patients suffering from primary or secondary MF which underwent HCT from 1997 to 2014 after either myeloablative (MAC, n = 19) or reduced-intensity conditioning (RIC, n = 35). Overall survival (OS) and disease-free survival (DFS) after 3 years was 54/53 % for RIC versus 63/58 % for MAC (p = 0.8/0.97). Cumulative incidence of relapse was 34 % after RIC and 8 % after MAC (p = 0.16). Three-year non-relapse mortality (NRM) was 15 % after RIC and 34 % after MAC (p = 0.29). We found that RIC was associated with a lower incidence of acute graft versus host disease (GvHD; II-IV 26 vs. 0 %, p = 0.004). Evaluation of prognostic relevance of the Dynamic International Prognostic Scoring System (DIPSS) score showed a significant better OS in patient with risk score ≤3 versus >3 (after 3 years, 71 vs. 39 %, p = 0.008). While similar OS and DFS were observed with MAC or RIC, the use of RIC resulted in lower incidence of acute GvHD. RIC regimens may be therefore the preferred conditioning approach for allogeneic HCT in patients with MF. PMID:27021303

  14. Potential proarrhythmic effect of cardiac resynchronization therapy during perioperative period: data from a single cardiac center

    LUO Nian-sang; YUAN Wo-liang; LIN Yong-qing; CHEN Yang-xin; MAO Xiao-qun; XIE Shuang-lun; KONG Min-yi; ZHOU Shu-xian; WANG Jing-feng

    2010-01-01

    Background Cardiac resynchronization therapy (CRT) could improve heart function, symptom status, quality of life and reduce hospitalization and mortality in patients with severe heart failure (HF) with optimal medical management. However,the possible adverse effects of CRT are often ignored by clinicians.Method A retrospective analysis of CRT over a 6-year period was made in a single cardiac center.Results Fifty-four patients were treated with CRT(D) device, aged (57±11) years, with left ventricular ejection fraction of (32.1±9.8)%, of which 4 (7%) developed ventricular tachycardia/ventricular fibrillation (VT/VF) or junctional tachycardia after operation. Except for one with frequent ventricular premature beat before operation, the others had no previous history of ventricular arrhythmia. Of the 4 patients, 3 had dilated cardiomyopathy and 1 had ischemic cardiomyopathy,and tachycardia occurred within 3 days after operation. Sustained, refractory VT and subsequent VF occurred in one patient, frequent nonsustained VT in two patients and nonparoxysmal atrioventricular junctional tachycardia in one patient. VT was managed by amiodarone in two patients, amiodarone together with beta-blocker in one patient, and junctional tachycardia was terminated by overdrive pacing. During over 12-month follow-up, except for one patient's death due to refractory heart and respiratory failure in hospital, the others remain alive and arrhythmia-free.Conclusions New-onset VT/VF or junctional tachycardia may occur in a minority of patients with or without prior history of tachycardia after biventricular pacing. Arrhythmia can be managed by conventional therapy, but may require temporary discontinuation of pacing. More observational studies should be performed to determine the potential proarrhythmic effect of CRT.

  15. Acute promyelocytic leukemia, study of predictive factors for Differentiation Syndrome, single center experience

    Reports about patients with acute promyelocytic leukemia from the Middle East are few; in this study we are reporting our single center experience of treating 29 patients over 6 years. Acute promyelocytic leukemia treatment response is markedly improved after the introduction of ATRA. Treatment related complication is still an important issue particularly Differentiation Syndrome. Prediction to its occurrence has been tried by other groups. We aimed to study all the possible predictive factors of acute promyelocytic leukemia. Our chemotherapy induction protocol is AIDA protocol which includes ATRA 45 mg/m2/d in divided doses every 12h, and Idarubicin 12 mg/ m2/d IV on days 3, 5, 7, and 9. Differentiation Syndrome occurred in 48.3% of patients and was mainly presented by pulmonary symptoms in 55.2%, 6 cases died during induction. None of the predictive factors studied showed a statistically significant difference between patients who developed Differentiation Syndrome and those who did not. Differentiation Syndrome did not affect overall survival. Cox regression showed an inverse yet a non significant association between PET- HEMA and overall survival probability (P = 0.168). In conclusion, Differentiation Syndrome has no clear predictive factor to date. The best approach is to hold ATRA and give dexamethasone which is quite effective as reported in the literature. PETHEMA risk model has a moderately significant prognostic value look for all possible predictive factors of Differentiation syndrome (DS) which were first described in 1992 by frankel et al. (4) and represented the major complication through this disease course: studies had reported conflicting results about this (5,6). In addition we will compare our data to other areas of the world

  16. Impact of Pediatric Chronic Dialysis on Long-Term Patient Outcome: Single Center Study.

    Levy Erez, Daniella; Krause, Irit; Dagan, Amit; Cleper, Roxana; Falush, Yafa; Davidovits, Miriam

    2016-01-01

    Objective. Owing to a shortage of kidney donors in Israel, children with end-stage renal disease (ESRD) may stay on maintenance dialysis for a considerable time, placing them at a significant risk. The aim of this study was to understand the causes of mortality. Study Design. Clinical data were collected retrospectively from the files of children on chronic dialysis (>3 months) during the years 1995-2013 at a single pediatric medical center. Results. 110 patients were enrolled in the study. Mean age was 10.7 ± 5.27 yrs. (range: 1 month-24 yrs). Forty-five children (42%) had dysplastic kidneys and 19 (17.5%) had focal segmental glomerulosclerosis. Twenty-five (22.7%) received peritoneal dialysis, 59 (53.6%) hemodialysis, and 6 (23.6%) both modalities sequentially. Median dialysis duration was 1.46 years (range: 0.25-17.54 years). Mean follow-up was 13.5 ± 5.84 yrs. Seventy-nine patients (71.8%) underwent successful transplantation, 10 (11.2%) had graft failure, and 8 (7.3%) continued dialysis without transplantation. Twelve patients (10.9%) died: 8 of dialysis-associated complications and 4 of their primary illness. The 5-year survival rate was 84%: 90% for patients older than 5 years and 61% for younger patients. Conclusions. Chronic dialysis is a suitable temporary option for children awaiting renal transplantation. Although overall long-term survival rate is high, very young children are at high risk for life-threatening dialysis-associated complications. PMID:27597898

  17. A single-center experience in radioembolization as salvage therapy of hepatic metastases of uveal melanoma

    Overall survival (OS) of patients with hepatic metastases of uveal melanoma is strongly linked with hepatic tumor control. Due to the lack of an effective systemic chemotherapy, locoregional therapies like radioembolization should play an increasingly important role. To report complications and response rates of radioembolization as salvage therapy for hepatic uveal melanoma metastases. Between October 2006 and January 2014, eight patients (age, 59.1 ± 15.3 years; 5 men) with histologically proven uveal melanoma and hepatic metastases received radioembolization with glass microspheres at a single center. All patients had been heavily pretreated with multiple systemic/locoregional therapies resulting in a long median interval between diagnosis of hepatic metastases and radioembolization (17.1 months; range, 6.4–23.2 months). Follow-up consisted of clinical assessment, laboratory tests and tri-phasic computed tomography (CT) before and 1, 3, 6, 9, and 12 months after radioembolization. Response to therapy was evaluated by CT using RECIST version 1.1 and by survival time. Safety (laboratory and clinical toxicity) was rated according to Common Terminology Criteria for Adverse Events 4.03. Using Kaplan-Meier analysis time to progression of hepatic metastases (hTTP) and OS were calculated. One month after radioembolization 50% of patients presented with stable and 50% with progressive disease. Median hTTP and OS after radioembolization were 4.3 weeks (range, 3.4–28.6 weeks) and 12.3 weeks (range, 3.7–62.6 weeks), respectively. Median OS after diagnosis of hepatic metastases was 19.9 months (range, 7.3–31.4 months). Radioembolization was tolerated well in all patients without toxicity higher than grade 2. Radioembolization is a safe salvage therapy even in heavily pretreated hepatic metastases of uveal melanoma

  18. Neonates born to mothers with immune thrombocytopenic purpura: a single-center experience of 20 years.

    Bayhan, Turan; Tavil, Betül; Korkmaz, Ayşe; Ünal, Şule; Hanalioğlu, Damla; Yiğit, Şule; Gümrük, Fatma; Çetin, Mualla; Yurdakök, Murat

    2016-01-01

    Neonates born to mothers with immune thrombocytopenic purpura (ITP) have an increased risk of having thrombocytopenia and bleeding. The aim of our study was to determine maternal and fetal factors that can predict bleeding risk in neonates born to mothers with ITP, and effective treatment strategies by retrospective analysis of our single-center data. We performed a retrospective data review of neonates that were recorded as 'neonates born to mothers with ITP' in the Neonatal ICU of Hacettepe University, Ihsan Dogramacı Children's Hospital, Ankara, Turkey. Medical records of 36 neonates born from 35 mothers were analyzed. Among the 36 neonates born to mothers with ITP, thrombocytopenia (platelet count of less than 150 × 10/l) was detected in 20 (56.0%) neonates on the first day of life. Twelve of the 20 neonates with thrombocytopenia (60.0%) required treatment to increase the platelet counts. Clinical findings related to thrombocytopenia occurred in three (15.0%) neonates, but none of them presented with severe bleeding. There was no statistically significant association between neonatal lowest platelet count and maternal lowest platelet count, maternal platelet count at the time of delivery, and duration of thrombocytopenia, respectively. Neonates born to mothers with ITP have an increased tendency to develop thrombocytopenia, but severe bleeding is very rare in these neonates. Clinicians should pay special attention to follow these neonates. According to our results, both intravenous immunoglobulin and methyl prednisolone were found to be in equivalent efficacy for the treatment of neonatal thrombocytopenia due to maternal ITP. PMID:26258676

  19. Prevalence of hyponatremia among patients who used indapamide and hydrochlorothiazide: A single center retrospective study

    M Al Qahtani

    2013-01-01

    Full Text Available Hyponatremia is the most frequently encountered electrolyte abnormality among hospitalized patients and thiazide users. In this large single-center retrospective study, we aim to determine the prevalence and risk factors of hyponatremia among patients at the King Abdulaziz Medical City (KAMC, Riyadh, Saudi Arabia.To the best of our knowledge, this is the first such study in Saudi Arabia. A chart review was done for the years 2011-2012 of all admitted Saudi patients at KAMC who were treated with indapamide and hydrochlorothiazide. A total of 2000 patients were included [1237 females (629 indapamide and 608 hydrochlorothiazide and 762 males (371 indapamide and 391 hydrochlorothiazide]. Majority of the patients had type-2 diabetes mellitus (T2DM with an overall prevalence of 72.2%. The overall prevalence of hyponatremia, regardless of severity, in the indapamide group was 37.3% versus 38.7% in the hydrochlorothiazide group. Stratification for age revealed that older patients had relatively higher levels of sodium (Na as compared with younger patients, and this inverse association was significant (R = - 0.123; P <0.001. Increasing age, female gender and presence of T2DM were the significant risk factors for hyponatremia, explaining the 4.7% of the variance perceived (P <0.001. Our study suggests that the prevalence of hyponatremia among Saudi thiazide users is relatively high, and more so for the elderly and for those with T2DM. Early identification of this condition is important and caution should be exercised while prescribing thiazide drugs, particularly to those who are most at risk of developing hyponatremia to prevent related complications.

  20. External validation of the SEDAN score: The real world practice of a single center

    Sombat Muengtaweepongsa

    2015-01-01

    Full Text Available Background and Purpose: Symptomatic intracranial hemorrhage (sICH is the most serious adverse event in stroke patients who received i.v. rt-PA and is usually associated with poor outcomes. The SEDAN score is built up to predict sICH. We aim to externally validate the SEDAN score in Thai patients from single center in the real world practice. Methods: The SEDAN score of stroke patients treated with intravenous rt-PA at Thammasat University Hospital from January 2010 to June 2012 was calculated. Patients were divided into three groups including symptomatic intracranial hemorrhage (sICH, asymptomatic intracranial hemorrhage (AsICH and no intracerebral hemorrhage (NoICH. The primary outcome of analyses was sICH. Each parameter of the SEDAN score and correlation between score and sICH were analyzed with univariate and multivariate model. Results: 295 patients (18.6% of stroke admission were treated with i.v. rt-PA. 13 patients (4.4% had sICH and 31 patients (10.4% had AsICH. Baseline blood sugar >12 mmol/l, early infarction, hyperdense cerebral artery, age >75 years-old and NIHSS ≥10(SEDAN were associated with sICH by univariate analysis (P value = 0.018, 12 mmol/l, early infarction, hyperdense cerebral artery, age >75 years-old and NIHSS ≥10 were 1.248, 2.503, 1.107, 1.532 and 1.263 respectively. Conclusions: The SEDAN score was practical to use and predictive in Thai population. Each parameter of the SEDAN score was an independent risk factor for sICH after treatment with i.v. rt-PA.

  1. Survival and causes of death in systemic sclerosis patients: a single center registry report from Iran.

    Poormoghim, Hadi; Andalib, Elham; Jalali, Arash; Ghaderi, Afshin; Ghorbannia, Ali; Mojtabavi, Nazanin

    2016-07-01

    The aims of the study were to determine prognostic factors for survival and causes of death in a cohort of patients with systemic sclerosis (SSc). This was a cohort study of SSc patients in single rheumatologic center from January 1998 to August 2012. They fulfilled the American College of Rheumatology classification criteria for SSc or had calcinosis Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia or sine sclerosis. Causes of death were classified as SSc related and non-SSc related. Kaplan-Meier and Cox proportional hazard regression models were used in univariate and multivariate analysis to analyse survival in subgroups and determine prognostic factors of survival. The study includes 220 patients (192 female, 28 male). Out of thirty-two (14.5 %) who died, seventeen (53.1 %) deaths were SSc related and in nine (28.1 %) non-SSc-related causes, and in six (18.8 %) of patients causes of death were not defined. Overall survival rate was 92.6 % (95 % CI 87.5-95.7 %) after 5 years and 82.3 % (95 % CI 73.4-88.4 %) after 10 years. Pulmonary involvement was a major SSc-related cause of death, occurred in seven (41.1 %) patients. Cardiovascular events were leading cause of in overall death (11) 34.3 % and 6 in non-SSc-related death. Independent risk factors for mortality were age >50 at diagnosis (HR 5.10) advance pulmonary fibrosis (HR 11.5), tendon friction rub at entry (HR 6.39), arthritis (HR 3.56). In this first Middle Eastern series of SSc registry, pulmonary and cardiac involvements were the leading cause of SSc-related death. PMID:27061806

  2. Mechanical Revascularization for Acute Ischemic Stroke: A Single-Center, Retrospective Analysis

    BackgroundEndovascular mechanical revascularization (thrombectomy) is an increasingly used method for intracranial large vessel recanalization in acute stroke. The purpose of the study was to analyze the recanalization rate, clinical outcome, and complication rate in our stroke patients treated with mechanical revascularization. A total of 57 patients with large vessel stroke (within 3 h for anterior and 12 h for posterior circulation) were treated with mechanical revascularization at a single center during 24 months. The primary goal of endovascular treatment using different mechanical devices was recanalization of the occluded vessel. Recanalization rate (reported as thrombolysis in cerebral infarction [TICI] score), clinical outcome (reported as National Institutes of Health Stroke Scale [NIHSS] score and modified Rankin scale [mRS] score), as well as periprocedural complications were analyzed. The mean age of the patients was 63.1 ± 12.9 years, with baseline median NIHSS score of 14 (interquartile range, 9.5–19). Successful recanalization (TICI 2b or 3) was achieved in 41 (72 %) patients. Twenty patients (35 %) presented with favorable outcome (mRS ≤2) 30 days after stroke. Overall, significant neurological improvement (≥4 NIHSS point reduction) occurred in 36 (63 %) patients. A clinically significant procedure-related adverse events (vessel disruption, peri/postprocedural intracranial bleeding) defined with decline in NIHSS of ≥4 or death occurred in three (5 %) patients. The study showed a high recanalization rate with improved clinical outcome and a low rate of periprocedural complications in our stroke patients treated with mechanical revascularization. Therefore, we could conclude that endovascular revascularization (primary or in combination with a bridging thrombolysis) was an effective and safe procedure for intracranial large vessel recanalization in acute stroke.

  3. The Risk Factors and Pregnancy Outcomes of 48 Cases of Heterotopic Pregnancy from a Single Center.

    Jeon, Ji Hyun; Hwang, Yu Im; Shin, Im Hee; Park, Chan Woo; Yang, Kwang Moon; Kim, Hye Ok

    2016-07-01

    The purpose of this study was to investigate risk factors that are associated with heterotopic pregnancy (HP) following in vitro fertilization (IVF)-embryo transfer (ET) and to demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. Forty-eight patients from a single center, who were diagnosed with HP between 1998 and 2012 were included. All of the patients had received infertility treatments, such as Clomid with timed coitus (n = 1, 2.1%), superovulation with intrauterine insemination (n = 7, 14.6%), fresh non-donor IVF-ET (n = 33, 68.8%), and frozen-thawed cycles (n = 7, 14.6%). Eighty-four additional patients were randomly selected as controls from the IVF registry database. HP was diagnosed at 7.5 ± 1.2 weeks (range 5.4-10.3) gestational age. In six cases (12.5%), the diagnosis was made three weeks after the patients underwent treatment for abortion. There were significant differences in the history of ectopic pregnancy (22.5% vs. 3.6%, P = 0.002). There were no significant differences in either group between the rates of first trimester intrauterine fetal loss (15.0% vs. 13.1%) or live birth (80.0% vs. 84.1%) after the surgical treatment for ectopic pregnancy. The risk factors for HP include a history of ectopic pregnancy (OR 7.191 [1.591-32.513], P = 0.010), abortion (OR 3.948 [1.574-9.902], P = 0.003), and ovarian hyperstimulation syndrome (OHSS) (OR 10.773 [2.415-48.060], P = 0.002). In patients undergoing IVF-ET, history of ectopic pregnancy, abortion, and OHSS may be risk factors for HP as compared to the control group of other IVF patients. The surgical treatment of HP does not appear to affect the rates of first trimester fetal loss or live birth. PMID:27366008

  4. Classifying Pediatric Central Nervous System Tumors through near Optimal Feature Selection and Mutual Information: A Single Center Cohort

    Mohammad Faranoush

    2013-10-01

    Full Text Available Background: Labeling, gathering mutual information, clustering and classificationof central nervous system tumors may assist in predicting not only distinct diagnosesbased on tumor-specific features but also prognosis. This study evaluates the epidemi-ological features of central nervous system tumors in children who referred to Mahak’sPediatric Cancer Treatment and Research Center in Tehran, Iran.Methods: This cohort (convenience sample study comprised 198 children (≤15years old with central nervous system tumors who referred to Mahak's PediatricCancer Treatment and Research Center from 2007 to 2010. In addition to the descriptiveanalyses on epidemiological features and mutual information, we used the LeastSquares Support Vector Machines method in MATLAB software to propose apreliminary predictive model of pediatric central nervous system tumor feature-labelanalysis. Results:Of patients, there were 63.1% males and 36.9% females. Patients' mean±SDage was 6.11±3.65 years. Tumor location was as follows: supra-tentorial (30.3%, infra-tentorial (67.7% and 2% (spinal. The most frequent tumors registered were: high-gradeglioma (supra-tentorial in 36 (59.99% patients and medulloblastoma (infra-tentorialin 65 (48.51% patients. The most prevalent clinical findings included vomiting,headache and impaired vision. Gender, age, ethnicity, tumor stage and the presence ofmetastasis were the features predictive of supra-tentorial tumor histology.Conclusion: Our data agreed with previous reports on the epidemiology of centralnervous system tumors. Our feature-label analysis has shown how presenting features maypartially predict diagnosis. Timely diagnosis and management of central nervous systemtumors can lead to decreased disease burden and improved survival. This may be furtherfacilitated through development of partitioning, risk prediction and prognostic models.

  5. The nature of luminescence centers in NaI:Eu single crystals

    Shiran, N., E-mail: natshiran@yahoo.com [Institute for Scintillation Materials, 60 Lenin Avenue, 61001 Kharkov (Ukraine); Gektin, A.; Boiaryntseva, Ia.; Vasyukov, S. [Institute for Scintillation Materials, 60 Lenin Avenue, 61001 Kharkov (Ukraine); Gridin, S. [Institute for Scintillation Materials, 60 Lenin Avenue, 61001 Kharkov (Ukraine); Institut Lumiere Matiere, Universite Claude Bernard Lyon 1, 69622 Villeurbanne Cedex (France); Belsky, A. [Institut Lumiere Matiere, Universite Claude Bernard Lyon 1, 69622 Villeurbanne Cedex (France)

    2015-08-15

    The nature of luminescence centers in NaI:Eu scintillation crystals was studied in a wide excitation energy and temperature ranges. Radio- and photoluminescence spectra and TSL curves were measured for crystals with varied activator concentrations. Two main narrow luminescence bands at 2.8 eV (center I) and 2.6 eV (center II) were found at 10 K. Center I dominates for low Eu concentration (<0.07%). Increase of activator content leads to suppression of center I emission and enhancement of center II. Presence of oxygen containing impurities in heavily doped crystals is due to high hygroscopicity of the NaI matrix and EuI{sub 2} dopant. Analysis of emission and thermoluminescence features allows justifying the role of anion impurities (oxygen/hydroxyl ions) in formation of activator center II, which is responsible for scintillation efficiency of NaI:Eu crystals at room temperature. - Highlights: • The optical and luminescence properties of NaI:Eu crystals have been studied. • Two types of activator centers were revealed. • The nature of emission centers is discussed.

  6. X-ray emission from interacting wind massive binaries: A review of 15 years of progress

    Rauw, Gregor; Nazé, Yaël

    2016-09-01

    Previous generations of X-ray observatories revealed a group of massive binaries that were relatively bright X-ray emitters. This was attributed to emission of shock-heated plasma in the wind-wind interaction zone located between the stars. With the advent of the current generation of X-ray observatories, the phenomenon could be studied in much more detail. In this review, we highlight the progress that has been achieved in our understanding of the phenomenon over the last 15 years, both on theoretical and observational grounds. All these studies have paved the way for future investigations using the next generation of X-ray satellites that will provide crucial information on the X-ray emission formed in the innermost part of the wind-wind interaction.

  7. Patch-test results in children and adolescents: systematic review of a 15-year period.

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-02-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined. PMID:26982781

  8. Patch-test results in children and adolescents: systematic review of a 15-year period*

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-01-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined. PMID:26982781

  9. Fulminant limb and retroperitoneal necrotizing fasciitis in a 15-year-old girl with Fanconi anaemia.

    O'Regan, Kevin

    2009-10-01

    Necrotizing fasciitis (NF) is an uncommon soft-tissue infection in children that carries a high mortality rate. We present a 15-year-old girl with chronic pancytopenia secondary to Fanconi anaemia who developed extensive NF of the lower limb, which unfortunately resulted in a fatal outcome. Immunodeficiency is a known risk factor for the development of this condition. The findings in this case demonstrate that patients with Fanconi anaemia may be susceptible to NF and that the clinical course may be more aggressive due to underlying immunosuppression. Prompt diagnosis of NF is vital in order to initiate appropriate treatment and to optimize patient outcome. Radiological investigation demonstrated extensive soft-tissue gas and destruction affecting the entire lower limb, abdominal wall and retroperitoneum, which led to timely definitive diagnosis and management.

  10. Fulminant limb and retroperitoneal necrotizing fasciitis in a 15-year-old girl with Fanconi anaemia.

    O'Regan, Kevin

    2012-01-31

    Necrotizing fasciitis (NF) is an uncommon soft-tissue infection in children that carries a high mortality rate. We present a 15-year-old girl with chronic pancytopenia secondary to Fanconi anaemia who developed extensive NF of the lower limb, which unfortunately resulted in a fatal outcome. Immunodeficiency is a known risk factor for the development of this condition. The findings in this case demonstrate that patients with Fanconi anaemia may be susceptible to NF and that the clinical course may be more aggressive due to underlying immunosuppression. Prompt diagnosis of NF is vital in order to initiate appropriate treatment and to optimize patient outcome. Radiological investigation demonstrated extensive soft-tissue gas and destruction affecting the entire lower limb, abdominal wall and retroperitoneum, which led to timely definitive diagnosis and management.

  11. A COMPARISON OF AUTOREFRACTOMETER WITH CYCLOPLEGIC RETINOSCOPY IN CHILDREN AGED 3 TO 15 YEARS

    Jaishree

    2015-09-01

    Full Text Available AIM: To compare the accuracy of the autorefractometer with traditional retinoscopy as a means of determining the approximate subjective refraction in children after cycloplegia. MATERIAL AND METHODS: Prospective observation study carried out in 72 eyes of 72 patients aged 3 to 15 years in upgraded department of Ophthalmology, LLRM Medical College, Meerut between April 2013 to June 2013. The negative spherical power of autorefracto meter was higher than retinoscopic group. The positive spherical power was lower in autorefractometer. DISCUSSION: Our observations in this younger age group amply that the inbuilt automatic fogging system of the autorefractometer fails to neutralize adequ ately the patient's accommodative efforts during manifest refraction. CONCLUSION: Manual retinoscopy is still the most accurate technique to estimate refractive status in children.

  12. Lumbar disc herniation associated with scoliosis in a 15-year-old girl: case report

    Pinto Fernando Campos Gomes

    2002-01-01

    Full Text Available Intervertebral disc herniation is a rare condition in childhood and adolescence, although some cases have already been reported in the literature. We present the case of a 15 year-old-girl with low back pain and scoliosis. She had no previous history of trauma or collagen diseases. MRI showed L4-L5 and L5-S1 disc herniations and no further bone and structural changes. After two level discectomy, pain ceased and scoliosis improved, without further treatment. Based on her evolution and on what has already been reported in literature, we consider that scoliosis associated with disc herniation in young patients is most likely to be only an anthalgic position, not indicative of further structural changes.

  13. The price of a 15-year delay in diagnosis of Sheehan's syndrome.

    Parikh, Rohan; Buch, Varun; Makwana, Mitesh; Buch, Harit N

    2016-04-01

    We describe a case of a 48-year-old woman who presented with a 15-year history of recurrent episodes of hypoglycemia and hyponatremia leading to altered behavior and generalized seizures. She underwent full clinical assessment, endocrine tests, and a pituitary magnetic resonance scan that showed pananterior hypopituitarism secondary to postpartum pituitary necrosis (Sheehan's syndrome). She was commenced on appropriate hormone replacement therapy, which led to significant improvement in lethargy, anorexia, muscle weakness, and episodes of hypoglycemia. In addition to the alleviation of her physical symptoms, she experienced a significant improvement in her psychological well-being and reduction in hospital visits. This case illustrates the impact of delay in diagnosis of an easily treatable medical condition and its socioeconomic implications, especially for the population of a developing country like India. PMID:27034575

  14. [Treatment of patients with clinical stage III and IV nonseminomas-- 15 years' experience].

    Base, J

    1991-12-01

    At the Urological Clinic in Hradec Králové in 1975-1989 a total of 182 patients with germ cell tumours of the testis--nonseminomas were treated. Of these patients 37 were in stage III-IV (20%). In 27 (72.9%) initial chemotherapy was administered, since 1980 combined with cisplatinum, as outlined. In 20 patients also revision of retroperitoneal nodes (54%) was made, to 19 patients adjuvant chemotherapy was administered (5th and 6th cycle). In 12 patients irradiation was indicated (32.4%). Histological examination of the preparation removed from the retroperitoneum was implemented in 15 patients: in four a vital tumour was revealed, in two a mature teratoma and in nine fibrosis or necrosis of a metastatic tumour was found. In seven patient a relapse of the disease occurred, 14 patients survive for 1-15 years. Twenty-three patients died. PMID:1822636

  15. Overweight, body image and bullying--an epidemiological study of 11- to 15-years olds

    Brixval, Carina S; Rayce, Signe L B; Rasmussen, Mette;

    2012-01-01

    BACKGROUND: The purpose of this study was to examine the association between weight status and exposure to bullying among 11-, 13- and 15-year-old Danish school children. Furthermore, the purpose was to investigate the potentially mediating effect of body image. METHODS: Data from the Danish...... ORs were 1.89 (1.25-2.85) in overweight and 2.74 (0.96-7.82) in obese girls. The mediation analyses showed that body image fully mediated the associations between weight status and exposure to bullying in both boys and girls. CONCLUSIONS: This study shows that overweight and obese boys and girls...... are of higher odds of being exposed to bullying than their normal weight peers. Moreover, this study finds that body image may statistically explain this association between overweight and exposure to bullying. However, the study is cross-sectional, and hypotheses of possibilities for opposite causality...

  16. LEGO-based Robotics in Higher Education: 15 Years of Student Creativity

    Ethan Danahy

    2014-02-01

    Full Text Available Our goal in this article is to reflect on the role LEGO robotics has played in college engineering education over the last 15 years, starting with the introduction of the RCX in 1998 and ending with the introduction of the EV3 in 2013. By combining a modular computer programming language with a modular building platform, LEGO Education has allowed students (of all ages to become active leaders in their own education as they build everything from animals for a robotic zoo to robots that play children’s games. Most importantly, it allows all students to develop different solutions to the same problem to provide a learning community. We look first at how the recent developments in the learning sciences can help in promoting student learning in robotics. We then share four case studies of successful college-level implementations that build on these developments.

  17. Single vs dual (en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience

    Al-Shraideh, Yousef; Farooq, Umar; El-Hennawy, Hany; Farney, Alan C; Palanisamy, Amudha; Rogers, Jeffrey; Orlando, Giuseppe; Khan, Muhammad; Reeves-Daniel, Amber; Doares, William; Kaczmorski, Scott; Gautreaux, Michael D; Iskandar, Samy S; Hairston, Gloria; Brim, Elizabeth; Mangus, Margaret; Stratta, Robert J

    2016-01-01

    AIM: To compare outcomes between single and dual en bloc (EB) kidney transplants (KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached to the inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors kidneys transplanted. Post-transplant management strategies were standardized in all patients. RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors (17 mo vs 38 mo, P kidney donor profile index (KDPI; 73% vs 62%) and levels of serum creatinine (SCr, 0.37 mg/dL vs 0.49 mg/dL, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence (12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay (mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection (6% vs 16%), operative complications (3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively (all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/dL vs 1.35 mg/dL and 72.5 mL/min per 1.73 m2 vs 60.5 mL/min per 1.73 m2 (both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. PMID:27011923

  18. Excitation of surface plasmon polariton modes with multiple nitrogen vacancy centers in single nanodiamonds

    Kumar, Shailesh; Lausen, Jens L.; Garcia-Ortiz, Cesar E.;

    2016-01-01

    Nitrogen-vacancy (NV) centers in diamonds are interesting due to their remarkable characteristics that are well suited to applications in quantum- information processing and magnetic field sensing, as well as representing stable fluorescent sources. Multiple NV centers in nanodiamonds (NDs) are e...

  19. Ageing implementation and refurbishment development at the IEA-R1 nuclear research reactor: a 15 years experience

    Cardenas, Jose Patricio N.; Ricci Filho, Walter; Carvalho, Marcos R. de; Berretta, Jose Roberto; Marra Neto, Adolfo, E-mail: ahiru@ipen.b, E-mail: wricci@ipen.b, E-mail: carvalho@ipen.b, E-mail: jrretta@ipen.b, E-mail: amneto@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    last 15 years. (author)

  20. Risperidone in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study

    Ercan, Eyüp Sabri; Kutlu, Ayşe; Çıkoğlu, Sibel; Veznedaroğlu, Baybars; Erermiş, Serpil; Varan, Azmi

    2003-01-01

    Background: Risperidone is one of the most commonly used atypical antipsychotic drugs in the treatment of children and adolescents. However, the data about its use in children and adolescents with conduct disorder (CD) are limited. Objective: The aim of this study was to investigate the effectiveness and tolerability of risperidone in controlling major symptoms of CD in children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and severe CD. Methods: Children and adolescents were eligible for this single-center, open-label study if they met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnostic criteria for ADHD and ODD and also were diagnosed with severe CD. The patients were treated with risperidone in an open-label fashion for 8 weeks, starting at a daily dosage of 0.25 mg or 0.5 mg (depending on their body weight) in 2 divided doses. Results: The study population comprised 21 children and adolescents (17 boys, 4 girls) with a mean (SD) age of 10.8 (3.6) years. The mean (SD) dosage of risperidone at the end of 8 weeks of treatment was 1.27 (0.42) mg/d (range, 0.75–2.0 mg/d). On the basis of the global improvement subscale of the Clinical Global Impression scale, 16 of 20 patients (80%) were classified as responders. Significant improvements were observed after risperidone treatment in the inattention, hyperactivity/impulsivity, ODD, and CD subscales of the Turgay DSM-IV–Based Child and Adolescent Behavior Disorders Screening and Rating Scale (parent and teacher forms). No severe adverse events were reported. Conclusions: The results of this study are consistent with previous findings and suggest that risperidone may be an effective and well-tolerated atypical antipsychotic drug for the treatment of children and adolescents with CD. However, further studies, particularly placebo-controlled and double-blinded, are needed to better define the clinical use

  1. Design and prototyping of self-centering optical single-mode fiber alignment structures

    Ebraert, Evert; Gao, Fei; Beri, Stefano; Watté, Jan; Thienpont, Hugo; Van Erps, Jürgen

    2016-06-01

    The European Commission’s goal of providing each European household with at least a 30 Mb s‑1 Internet connection by 2020 would be facilitated by a widespread deployment of fibre-to-the-home, which would in turn be sped up by the development of connector essential components, such as high-precision alignment features. Currently, the performance of state-of-the-art physical contact optical fiber connectors is limited by the tolerance on the cladding of standard telecom-grade single-mode fiber (SMF), which is typically smaller than  ±1 μm. We propose to overcome this limit by developing micro-spring-based self-centering alignment structures (SCAS) for SMF-connectors. We design these alignment structures with robustness and low-cost replication in mind, allowing for large-scale deployment. Both theoretical and finite element analysis (FEA) models are used to determine the optimal dimensions of the beams of which the micro-springs of the SCAS are comprised. Two topologies of the SCAS, consisting of three and four micro-springs respectively, are investigated for two materials: polysulfone (PSU) and polyetherimide (PEI). These materials hold great potential for high-performance fiber connectors while being compatible with low-cost production and with the harsh environmental operation conditions of those connectors. The theory and FEA agree well (<3% difference) for a simple micro-spring. When including a pedestal on the micro-spring (to bring it further away from the fiber) and for shorter spring lengths the agreement worsens. This is due to spring compression effects not being taken into account in our theoretical model. Prototypes are successfully fabricated using deep proton writing and subsequently characterized. The controlled insertion of an SMF in the SCAS is investigated and we determine that a force of 0.11 N is required. The fiber insertion also causes an out-of-plane deformation of the micro-springs in the SCAS of about 7 μm, which is no problem

  2. Design and prototyping of self-centering optical single-mode fiber alignment structures

    Ebraert, Evert; Gao, Fei; Beri, Stefano; Watté, Jan; Thienpont, Hugo; Van Erps, Jürgen

    2016-06-01

    The European Commission’s goal of providing each European household with at least a 30 Mb s‑1 Internet connection by 2020 would be facilitated by a widespread deployment of fibre-to-the-home, which would in turn be sped up by the development of connector essential components, such as high-precision alignment features. Currently, the performance of state-of-the-art physical contact optical fiber connectors is limited by the tolerance on the cladding of standard telecom-grade single-mode fiber (SMF), which is typically smaller than  ±1 μm. We propose to overcome this limit by developing micro-spring-based self-centering alignment structures (SCAS) for SMF-connectors. We design these alignment structures with robustness and low-cost replication in mind, allowing for large-scale deployment. Both theoretical and finite element analysis (FEA) models are used to determine the optimal dimensions of the beams of which the micro-springs of the SCAS are comprised. Two topologies of the SCAS, consisting of three and four micro-springs respectively, are investigated for two materials: polysulfone (PSU) and polyetherimide (PEI). These materials hold great potential for high-performance fiber connectors while being compatible with low-cost production and with the harsh environmental operation conditions of those connectors. The theory and FEA agree well (deep proton writing and subsequently characterized. The controlled insertion of an SMF in the SCAS is investigated and we determine that a force of 0.11 N is required. The fiber insertion also causes an out-of-plane deformation of the micro-springs in the SCAS of about 7 μm, which is no problem for robustness according to the FEA model. Finally connector-assemblies are made with the alignment system and we show that an insertion loss down to 0.1 dB is achievable. The prototypes are subsequently used as a sacrificial master for mould fabrication through electroplating with the goal of low-cost replication through hot

  3. Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single-center study.

    Eloïse Giabicani

    Full Text Available BACKGROUND: Despite the number of reported data concerning idiopathic central precocious puberty (CPP in girls, major questions remain including its diagnosis, factors, and indications of gonadotropin releasing hormone (GnRH analog treatment. METHODS: A retrospective, single-center study was carried out on 493 girls with CPP. RESULTS: Eleven girls (2.2% were aged less than 3 years. Breast development was either isolated (Group 0, n = 99, or associated with one sign, pubic hair development, growth rate greater than 2 standard deviation score (SDS or bone age (BA >2 years above chronological age, (Group 1, n = 187, two signs (Group 2, n = 142 or three signs (Group 3, n = 65. The interval between onset of puberty and evaluation, body mass index (BMI SDS, plasma luteinising hormone (LH concentrations (basal and peak and LH/ follicle-stimulating hormone (FSH peak ratio after GnRH test, plasma estradiol and uterus length were significantly greater in Groups 2 and 3 than in Groups 0 and 1 respectively. 211 (42.8% patients were obese and/or had excessive weight gain during the year before puberty. Obese girls more often had BA advance of >2 years (p = 0.0004 and pubic hair development (p = 0.003 than the others. BMI did not correlate with LH or with LH/FSH peak ratio. Girls with familial history of early puberty (41.4% had greater frequencies of pubertal LH/FSH peak ratios (p = 0.02 than the others. During the 31 years of the study, there was no increase in the frequency of CPP or variation in its characteristics. CONCLUSION: Obesity is associated with a higher BA advance and higher frequency of pubic or axillary hair development but not with LH secretion, suggesting that obesity accelerates adrenarche but not the maturation of the hypothalamic-pituitary-ovarian axis. The LH/FSH peak ratio was more frequently pubertal in girls with a familial history of early puberty, suggesting that this maturation depends on genetic factors.

  4. Patient radiation dose in diagnostic and interventional procedures for intracranial aneurysms: Experience at a single center

    Chun, Chang Woo; Kim, Bum Soo; Lee, Cheol Hyoun; Ihn, Yon Kwon; Shin, Yong Sam [Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul(Korea, Republic of)

    2014-12-15

    To assess patient radiation doses during cerebral angiography and embolization of intracranial aneurysms in a large sample size from a single center. We studied a sample of 439 diagnostic and 149 therapeutic procedures for intracranial aneurysms in 480 patients (331 females, 149 males; median age, 57 years; range, 21-88 years), which were performed in 2012 with a biplane unit. Parameters including fluoroscopic time, dose-area product (DAP), and total angiographic image frames were obtained and analyzed. Mean fluoroscopic time, total mean DAP, and total image frames were 12.6 minutes, 136.6 +/- 44.8 Gy-cm{sup 2}, and 251 +/- 49 frames for diagnostic procedures, 52.9 minutes, 226.0 +/- 129.2 Gy-cm{sup 2}, and 241 frames for therapeutic procedures, and 52.2 minutes, 334.5 +/- 184.6 Gy-cm{sup 2}, and 408 frames for when both procedures were performed during the same session. The third quartiles for diagnostic reference levels (DRLs) were 14.0, 61.1, and 66.1 minutes for fluoroscopy time, 154.2, 272.8, and 393.8 Gy-cm{sup 2} for DAP, and 272, 276, and 535 for numbers of image frames in diagnostic, therapeutic, and both procedures in the same session, respectively. The proportions of fluoroscopy in DAP for the procedures were 11.4%, 50.5%, and 36.1%, respectively, for the three groups. The mean DAP for each 3-dimensional rotational angiographic acquisition was 19.2 +/- 3.2 Gy-cm{sup 2}. On average, rotational angiography was used 1.4 +/- 0.6 times/session (range, 1-4; n = 580). Radiation dose in our study as measured by DAP, fluoroscopy time and image frames did not differ significantly from other reported DRL studies for cerebral angiography, and DAP was lower with fewer angiographic image frames for embolization. A national registry of radiation-dose data is a necessary next step to refine the dose reference level.

  5. Clinical results of atrial fibrillation patients treated with cryoballoon ablation: A single center experience

    Mesut Aydın

    2014-12-01

    Full Text Available Objectives: Atrial fibrillation (AF, the most common arrhythmia in clinical practice, is a major cause of stroke. Atrial fibrillation increases morbidity and mortality. Nowadays cryoablation therapy is being performed efficiently and safely worldwide. In this paper the clinical outcomes of the patients whom were treated with cryoablation were discussed. Methods: Between June 2012 and March 2014, patients with paroxysmal AF who were treated with cryoablation were included in the study. The medical records of the patients were retrospectively reviewed. Patients were called to receive information about the symptom recurrence. Results: Twelve patients were included in the study. Half of the patients were female. The mean age was 48 ± 15 years. Acute procedural success rate of cryoablation was 100%. In one patient transient right phrenic nerve injury occurred which was returned to normal after discontinuation of cryoablation therapy. One patient developed AF episode for 10 minutes in the 4th month of follow-up period. Conclusion: In patients with paroxysmal atrial fibrillation cryoablation effectively decrease symptoms consistent with the literature. J Clin Exp Invest 2014; 5 (4: 599-603

  6. Clinical Outcomes of Heart-Lung Transplantation: Review of 10 Single-Center Consecutive Patients

    Yun, Jae Kwang; Choi, Se Hoon; Park, Seung-Il; [...

    2016-01-01

    Background Heart-lung transplantation (HLT) has provided hope to patients with end-stage lung disease and irreversible heart dysfunction. We reviewed the clinical outcomes of 10 patients who underwent heart-lung transplantation at Asan Medical Center. Methods Between July 2010 and August 2014, a total of 11 patients underwent HLT at Asan Medical Center. After excluding one patient who underwent concomitant liver transplantation, 10 patients were enrolled in our study. We reviewed the demograp...

  7. Controling the single-diamond nitrogen-vacancy color center photoluminescence spectrum with a Fabry-Perot microcavity

    We present here both theoretical and experimental results on the fluorescence of single defect centers in diamond nanocrystals embedded in a planar dielectric microcavity. From a theoretical point of view, we show that the overall fluorescence collection efficiency using a moderate numerical aperture microscope objective can be enhanced by using a low-quality-factor microcavity. This could be used in particular for low-temperature applications, where the numerical aperture of collection microscope objectives is limited due to the experimental constraints. We experimentally investigate the control of the fluorescence spectrum of the emitted light from a single center. We show the simultaneous narrowing of the room temperature broadband emission spectrum and the increase in the fluorescence spectral density.

  8. Controling the single-diamond nitrogen-vacancy color center photoluminescence spectrum with a Fabry-Perot microcavity

    Dumeige, Yannick [Universite Europeenne de Bretagne, Laboratoire Foton, CNRS UMR 6082 Foton, Enssat, 6 rue de Kerampont, 22305 Lannion Cedex (France); Alleaume, Romain [Institut Telecom/Telecom ParisTech, Laboratoire Traitement et Communication de l' Information, CNRS UMR 5141, 46 rue Barrault, 75634 Paris Cedex (France); Grangier, Philippe [Laboratoire Charles Fabry de l' Institut d' Optique, CNRS UMR 8501, Institut d' Optique Graduate School, Campus Polytechnique-RD 128, 2 avenue Augustin Fresnel 91127 Palaiseau Cedex (France); Treussart, Francois; Roch, Jean-Francois, E-mail: yannick.dumeige@univ-rennes1.fr [Laboratoire de Photonique Quantique et Moleculaire, CNRS UMR 8537, Ecole Normale Superieure de Cachan, 61 avenue du President Wilson, 94235 Cachan Cedex (France)

    2011-02-15

    We present here both theoretical and experimental results on the fluorescence of single defect centers in diamond nanocrystals embedded in a planar dielectric microcavity. From a theoretical point of view, we show that the overall fluorescence collection efficiency using a moderate numerical aperture microscope objective can be enhanced by using a low-quality-factor microcavity. This could be used in particular for low-temperature applications, where the numerical aperture of collection microscope objectives is limited due to the experimental constraints. We experimentally investigate the control of the fluorescence spectrum of the emitted light from a single center. We show the simultaneous narrowing of the room temperature broadband emission spectrum and the increase in the fluorescence spectral density.

  9. Young-type experiment using a single-electron source and an independent atomic-size two-center interferometer.

    Chesnel, J-Y; Hajaji, A; Barrachina, R O; Frémont, F

    2007-03-01

    Evidence is given for Young-type interferences caused by a single electron acting on a given double-center scatterer analogous to an atomic-size double-slit system. The electron is provided by autoionization of a doubly excited He atom following the capture of the electrons of H2 by a He2+ incoming ion. The autoionizing projectile is a single-electron source, independent of the interferometer provided by the two H+ centers of the fully ionized H2 molecule. This experiment resembles the famous thought experiment imagined by Feynman in 1963, in which the quantum nature of the electron is illustrated from a Young-like double-slit experiment. Well-defined oscillations are visible in the angular distribution of the scattered electrons, showing that each electron interferes with itself. PMID:17358516

  10. Persistence of artificial sweeteners in a 15-year-old septic system plume

    Robertson, W. D.; Van Stempvoort, D. R.; Solomon, D. K.; Homewood, J.; Brown, S. J.; Spoelstra, J.; Schiff, S. L.

    2013-01-01

    SummaryGroundwater contamination from constituents such as NO3-, often occurs where multiple sources are present making source identification difficult. This study examines a suite of major ions and trace organic constituents within a well defined septic system plume in southern Ontario, Canada (Long Point site) for their potential use as wastewater tracers. The septic system has been operating for 20 years servicing a large, seasonal-use campground and tritium/helium age dating indicates that the 200 m long monitored section of the plume is about 15 years old. Four parameters are elevated along the entire length of the plume as follows; the mean electrical conductivity value (EC) in the distal plume zone is 926 μS/cm which is 74% of the mean value below the tile bed, Na+ (14.7 mg/L) is 43%, an artificial sweetener, acesulfame (12.1 μg/L) is 23% and Cl- (71.5 mg/L) is 137%. EC and Cl- appear to be affected by dispersive dilution with overlying background groundwater that has lower EC but has locally higher Cl- as result of the use of a dust suppressant (CaCl2) in the campground. Na+, in addition to advective dilution, could be depleted by weak adsorption. Acesulfame, in addition to the above processes could be influenced by increasing consumer use in recent years. Nonetheless, both Na+ and acesulfame remain elevated throughout the plume by factors of more than 100 and 1000 respectively compared to background levels, and are strong indicators of wastewater impact at this site. EC and Cl- are less useful because their contrast with background values is much less (EC) or because other sources are present (Cl-). Nutrients (NO3-, NH4+, PO43-, K+) and pathogens (Escherichia coli) do not persist in the distal plume zone and are less useful as wastewater indicators here. The artificial sweetener, acesulfame, has persisted at high concentrations in the Long Point plume for at least 15 years (and this timing agrees with tritium/helium-3 dating) and this compound likely

  11. Relationship between salivary fluor concentration and caries index in 12–15 years old children

    Vidyana Pratiwi

    2012-03-01

    Full Text Available Background: Dental caries is a bacterial infection leading to dissolution and localized damage of hard tissues. The assessment of caries risk is based on several caries indicators including clinical conditions (DMF-T index, environment (fluor, and general health. Purpose: The objective of this study was to assess the relationship between salivary fluor concentration and caries index in children aging 12–15 years old at SMP Negeri 2 PTPN VIII Pangalengan. Methods: This study is an observational analytical study using crosssectional approach and is conducted in a field trial manner. The study sample consists of 80 students in the age of 12 to 15 years old at SMP Negeri 2 PTPN VIII selected through Probability Sampling manner using simple random sampling method. Results: The result of this study shows a DMF-T index of 4.32 and salivary fluor concentration mean of 0.018. Pearson Product Moment correlation test shows that there is a weak correlation between salivary fluor concentration and DMF-T index. Conclusion: It is concluded that the salivary fluor concentration has an insignificant correlation with the DMF-T index since the fluor concentration in saliva is very low.Latar belakang: Karies gigi adalah penyakit infeksi bakteri yang berakibat pada disolusi dan kerusakan terlokalisasi jaringan keras. Penilaian risiko karies berdasarkan atas beberapa indikator karies yaitu kondisi klinis (indeks DMF-T, lingkungan (fluor, dan kesehatan umum. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan konsentrasi fluor yang terdapat dalam saliva dengan indeks karies pada anak usia 12-15 tahun di SMP Negeri 2 PTPN VIII Pangalengan. Metode: Jenis penelitian ini adalah penelitian analitik observasional dengan pendekatan cross sectional yang dilakukan di lapangan. Sampel penelitian sebanyak 80 orang siswasiswi usia 12–15 tahun di SMP Negeri 2 PTPN VIII Pangalengan yang dipilih secara Probability Sampling dengan metode simple random sampling. Hasil

  12. Iron status of schoolchildren (6–15 years and associated factors in rural Nigeria

    Rufina N. B. Ayogu

    2015-05-01

    Full Text Available Background: Schoolchildren are vulnerable to anaemia because of their higher iron need to meet the demands of puberty and adolescence. Objective: The survey determined the haemoglobin levels of schoolchildren aged 6–15 years and the factors affecting their haemoglobin status. Design: Data were obtained through a cross sectional survey of 450 randomly selected schoolchildren in Ede-Oballa, Nsukka, Enugu State, Nigeria. Ninety were selected for clinical examination, biochemical tests, and nutrient intake study. Haemoglobin, malaria, and stool analysis were carried out by the cyanmethaemoglobin, thin blood film, and wet mount direct methods, respectively. Iron intake was determined by a three-day weighed food intake. Results: Results showed that the schoolchildren had pallor (35.6%, brittle hair (31.1%, koilonychia (2.2%, oedema (4.4% and sore/smooth tongue (7.8%. The children also had malaria (58.9% and Entamoeba histolytica (42.2%, hookworm (36.7%, tapeworm (35.6%, whipworm (34.5%, and roundworm (27.9% infestations. Iron intake was inadequate (<100% of recommended nutrient intake for most of the children. The mean haemoglobin levels of the schoolchildren were low. The 6–9, 10–12, and 13–15 year olds had 9.0, 9.1, and 9.3 g/dl, respectively. Most (85.5% of them had anaemia. Moderate anaemia was prevalent in 62.2%. Severe anaemia affected the 6–9 year olds more. Malaria (P<0.001, Entamoeba histolytica (P<0.01, hookworm (P<0.05, tapeworm (P<0.01, and whipworm (P<0.001 caused significant reduction in haemoglobin level. Age (b=1.284, P<0.05, birth order (b=−0.629, P<0.01, frequency of illness attack (b=−1.372, P<0.01, household size (b=−0.526, P<0.05, and frequency of skipping breakfast (b=−1.542, P<0.001 were factors that influenced the haemoglobin status of the children. Conclusion: The schoolchildren had poor iron status as a result of consumption of plant sources of iron with low bioavailability, parasitic infections, birth order

  13. The AmBulatory Closure Device Percutaneous Intervention (ABCD-PCI) study: a single-center experience

    Falcone, Adam M.; Bose, Rahul; Stoler, Robert C; Kim, Michael; Laible, Emily; Kang, Lucy; Waters, Kim; Dunkerley, Janet; Choi, James W.

    2011-01-01

    The AmBulatory Closure Device Percutaneous Intervention (ABCD-PCI) study is a multicenter randomized prospective controlled trial evaluating the safety of and patient satisfaction with same-day discharge following ambulatory percutaneous intervention with a closure device. This article reviews the findings from a single center, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, from October 2008 through April 2010, with 23 patients in the same-day discharge group and 21 patients in th...

  14. Polyethylene Glycol Electrolyte Lavage Solution versus Colonic Hydrotherapy for Bowel Preparation before Colonoscopy: A Single Center, Randomized, and Controlled Study

    Yan Cao; Kai-Yuan Zhang; Jiao Li; Hao Lu; Wan-Ling Xie; Sheng-Tao Liao; Dong-Feng Chen; Deng-Feng Zeng; Chun-Hui Lan

    2014-01-01

    This single center, randomized, and controlled study aimed to compare the effectiveness and safety of polyethylene glycol electrolyte lavage (PEG-EL) solution and colonic hydrotherapy (CHT) for bowel preparation before colonoscopy. A total of 196 eligible outpatients scheduled for diagnostic colonoscopy were randomly assigned to the PEG-EL (n = 102) or CHT (n = 94) groups. Primary outcome measures included colonic cleanliness and adverse effects. Secondary outcome measures were patient satisf...

  15. Cystic fibrosis-related liver disease: a single-center experience

    Paula Catarino Costa

    2011-10-01

    Full Text Available Prospective studies concerning liver disease in pediatric cystic fibrosis patients are scarce. The present study aimed to describe the prevalence and clinical expression of cystic fibrosis - related liver disease, in a cohort of 62 pediatric patients. Descriptive study, resulting from the prospective evaluation, between 1994 and 2009, of 62 pediatric patients (age <18 years with cystic fibrosis. The follow-up protocol included a clinical assessment every 2 months, liver function tests every 6 months and annual liver ultrasonography. The cumulative prevalence of liver disease was 11.2% (7/62 cases. All patients had ΔF508 mutation and pancreatic insufficiency, none had meconium ileus. The liver involvement became clinically evident at a mean age of 8 years (3-15 years, revealed by hepatomegaly or hepatosplenomegaly (3 cases and/ or abnormalities of liver function tests (3 cases changes of liver ultrasound (7 cases with evidence of portal hypertension (2 cases. Four patients were submitted to liver biopsy; biliary fibrosis was documented in one case, focal biliary cirrhosis in 2 cases and multilobular cirrhosis in another case. Within a median 11.6 years follow-up period (all patients under UDCA therapy after liver disease diagnosis, progression of liver disease was observed in 2 patients; one patient developed refractory variceal bleeding and progressive hepatic failure, requiring liver transplant. The results of the present study agree with those of previous pediatric studies, further documenting clinical expression of liver disease in CF patients, which is usually detected in the first decade of life and emphasize the contribution of ultrasound to early diagnosis of liver involvement. Moreover, although advanced liver disease is a relatively rare event, early isolated liver transplantation may have to be considered at this age group.

  16. Combined immunodeficiencies: twenty years experience from a single center in Turkey.

    Akar, H Haluk; Patiroglu, Turkan; Hershfield, Michael; van der Burg, Mirjam

    2016-01-01

    Combined immunodeficiencies (CIDs) include a group of inherited monogenic disorders. CIDs are characterized by defective cellular and humoral immunities that lead to severe infections. CIDs can be classified according to immunologic phenotypes as T(-)B(-)NK(-) CID, T(-)B(-)NK(+) CID, T(-)B(+)NK(-) CID and T(-)B(+)NK(+) CID. In a 20-year period, from 1994 to 2014, a total of 40 CID patients were diagnosed at the Pediatric Immunology of Erciyes University Medical Faculty in Kayseri, Turkey. The gender ratio (F/M) was 3/5. The median age at the onset of symptoms was 2 months (range, 15 days - 15 years). Of the 14 T(-)B(-)NK(-) CIDs, 6, 2 (siblings), 1, 1 and 4 had a mutation in the ADA, PNP, Artemis, RAG1 genes and unknown genetic diagnosis respectively. Of the 15 T(-)B(-)NK(+) CIDs, 3, 2 (siblings) and 10 had a mutation in the RAG1, XLF/Cernunnos genes and unknown genetic diagnosis respectively. Of the 9 T(-)B(+)NK(-) CIDs, 2 siblings, 1, 1 and 5 had a mutation in the ZAP70, IL2RG, DOCK8 genes and unknown genetic diagnosis respectively. Of the 2 T(-)B(+)NK(+) CIDs, 2 had a mutation in the MAGT1 and ZAP70 genes respectively. Of the 40 CIDs, 26 (65%) were died and 14 (35%) are alive. Eight patients received HSCT (hematopoietic stem cell transplantation) with 62.5% survival rate. As a result, patients presented with severe infections in the first months of life have to be examined for CIDs. Shortening time of diagnosis would increase chance of HSCT as life-saving treatment in the CID patients. PMID:27095930

  17. Radiotherapy of Painful Vertebral Hemangiomas: The Single Center Retrospective Analysis of 137 Cases

    Purpose: An evaluation of dose–response relationship and an attempt to define predictive factors. Methods and Materials: A total of 137 cases of painful vertebral hemangioma irradiations (101 patients). Fraction dose (fd) varied from 2 to 15 Gy (123 fractionated and 14 radiosurgical treatments), and total dose (TD) from 8 to 30 Gy (111 cases irradiated with fd of 2 GY to TD of 24 Gy). We evaluated pain relief, changes in analgesic requirements, and reossification. Results: Means of pain relief 1, 6, 12, and 18 months after radiotherapy (defined as a decrease of primary pain level expressed in percent) were 60.5%, 65.4%, 68.3%, and 78.4%, respectively. Proportion of patients with no need for analgesics and patients using tramadol were 39%, 40%, 44%, 57%, and 20%, 17%, 22%, and 11% in these times. The proportion of patients experiencing complete/partial pain relief changed from 36/48% 1 month, to 64/22% 1.5 years after radiotherapy. No impact of radiotherapy on reossification was found. The positive impact of fd and TD increase for analgesics uptake reduction and pain relief was found. An increase of the fd by 1 Gy results in 27% chance of analgesics uptake reduction and 3.8% reduction of pain, whereas 14% analgesics uptake reduction and 2.2% of pain reduction in case of the TD. The predictive factors improving results were found: female gender, older age, better performance states (the chance of the lower analgesic treatment decreases over 2.5 times in comparison to the higher Zubrod degree), bigger Hb concentration, shorter symptoms duration and lower analgesics uptake before radiotherapy. Conclusions: The obtained data support the efficacy of radiotherapy in improving pain secondary to vertebral hemangioma, with the degree of pain amelioration being related to increasing fd and TD. The positive predictive factors were defined: female gender, older age, better performance status, increased Hb concentration, shorter symptoms duration, and lower analgesics uptake before radiotherapy.

  18. Excitation of surface plasmon polariton modes with multiple nitrogen vacancy centers in single nanodiamonds

    Kumar, Shailesh; Lausen, Jens L.; Garcia-Ortiz, Cesar E.; Andersen, Sebastian K. H.; Roberts, Alexander S.; Radko, Ilya P.; Smith, Cameron L. C.; Kristensen, Anders; Bozhevolnyi, Sergey I.

    2016-02-01

    Nitrogen-vacancy (NV) centers in diamonds are interesting due to their remarkable characteristics that are well suited to applications in quantum-information processing and magnetic field sensing, as well as representing stable fluorescent sources. Multiple NV centers in nanodiamonds (NDs) are especially useful as biological fluorophores due to their chemical neutrality, brightness and room-temperature photostability. Furthermore, NDs containing multiple NV centers also have potential in high-precision magnetic field and temperature sensing. Coupling NV centers to propagating surface plasmon polariton (SPP) modes gives a base for lab-on-a-chip sensing devices, allows enhanced fluorescence emission and collection which can further enhance the precision of NV-based sensors. Here, we investigate coupling of multiple NV centers in individual NDs to the SPP modes supported by silver surfaces protected by thin dielectric layers and by gold V-grooves (VGs) produced via the self-terminated silicon etching. In the first case, we concentrate on monitoring differences in fluorescence spectra obtained from a source ND, which is illuminated by a pump laser, and from a scattering ND illuminated only by the fluorescence-excited SPP radiation. In the second case, we observe changes in the average NV lifetime when the same ND is characterized outside and inside a VG. Fluorescence emission from the VG terminations is also observed, which confirms the NV coupling to the VG-supported SPP modes.

  19. Cytomegalovirus Pneumonia in Patients with Rheumatic Diseases After Immunosuppressive Therapy: A Single Center Study in China

    Yu Xue; Li Jiang; Wei-Guo Wan; Yu-Ming Chen; Jiong Zhang; Zhen-Chun Zhang

    2016-01-01

    Background: Rheumatic diseases involve multiple organs that are affected by immunological mechanisms.Treatment with corticosteroids and immunosuppressive agents may also increase the frequency of infection.Cytomegalovirus (CMV) is a widespread herpes virus and a well-recognized pathogen, which causes an opportunistic and potentially fatal infection in immunocompromised patients.This retrospective study aimed to investigate the clinical and laboratory characteristics of CMV pneumonia in patients with rheumatic diseases after immunosuppressive therapy in a single center in Shanghai, China.Methods: Eight hundred and thirty-four patients with rheumatic diseases who had undergone CMV-DNA viral load tests were included, and the medical records of 142 patients who were positive for CMV-DNA in plasma samples were evaluated.GraphPad Prism version 5.013 (San Diego, CA, USA) was used to conduct statistical analysis.The correlation between CMV-DNA viral loads and lymphocyte counts was assessed using the Spearman rank correlation coefficient test.Significance between qualitative data was analyzed using Pearson's Chi-squared test.The cut-offthresholds for CMV-DNA viral load and lymphocyte count were determined by receiver operating characteristic (ROC) curve analysis.Results: One hundred and forty-two patients had positive CMV viral load tests.Of these 142 patients, 73 patients with CMV pneumonia were regarded as symptomatic, and the other 69 were asymptomatic.The symptomatic group received higher doses ofprednisolone (PSL) and more frequently immunosuppressants than the asymptomatic group (P < 0.01).The symptomatic group had lower lymphocyte counts, especially CD4+ T-cells, than the asymptomatic group (P < 0.01).By ROC curve analysis, when CD4+ T-cell count was <0.39 × 109/L, patients with rheumatic diseases were at high risk for symptomatic CMV infection.The CMV-DNA load was significantly higher in the symptomatic patients than that in asymptomatic patients (P < 0

  20. Exposure to secondhand smoke among students aged 13-15 years--worldwide, 2000-2007.

    2007-05-25

    Breathing secondhand smoke (SHS) causes heart disease and lung cancer in adults and increased risks for sudden infant death syndrome, acute respiratory infections, middle-ear disease, worsened asthma, respiratory symptoms, and slowed lung growth in children. No risk-free level of exposure to SHS exists. The Global Youth Tobacco Survey (GYTS), initiated in 1999 by the World Health Organization (WHO), the Canadian Public Health Association, and CDC includes questions related to tobacco use, including exposure to SHS. This report examines data collected from 137 jurisdictions (i.e., countries and territories) during 2000-2007, presents estimates of exposure to SHS at home and in places other than the home among students aged 13-15 years who had never smoked, and examines the association between exposure to SHS and susceptibility to initiating smoking. GYTS data indicated that nearly half of never smokers were exposed to SHS at home (46.8%), and a similar percentage were exposed in places other than the home (47.8%). Never smokers exposed to SHS at home were 1.4-2.1 times more likely to be susceptible to initiating smoking than those not exposed. Students exposed to SHS in places other than the home were 1.3-1.8 times more likely to be susceptible to initiating smoking than those not exposed. As part of their comprehensive tobacco-control programs, countries should take measures to create smoke-free environments in all indoor public places and workplaces. PMID:17522587

  1. Facial Emotion and Identity Processing Development in 5- to 15-Year-Old Children

    Patrick eJohnston

    2011-02-01

    Full Text Available Most developmental studies of emotional face processing to date have focussed on infants and very young children. Additionally, studies that examine emotional face processing in older children do not distinguish development in emotion and identity face processing from more generic age-related cognitive improvement. In this study, we developed a paradigm that measures processing of facial expression in comparison to facial identity and complex visual stimuli. The three matching tasks were developed (i.e., facial emotion matching, facial identity matching and butterfly wing matching to include stimuli of similar level of discriminability and to be equated for task difficulty in earlier samples of young adults. Ninety two children aged 5 to 15 years and a new group of 24 young adults completed these three matching tasks. Young children were highly adept at the butterfly wing task relative to their performance on both face-related tasks. More importantly, in older children, development of facial emotion discrimination ability lagged behind that of facial identity discrimination.

  2. 'Radiation Fair' for 15 years in Osaka, Japan, and survey of the participants attitude toward radiation

    We have been successfully operating 'Radiation Fair--The relationship between daily life and radiation--' during summer vacation season in August every year for 15 years in Osaka, the largest city of western Japan. The purpose of this event is radiation education of public including school kids through efficient information transfer of radiation and radiation-related technology. Currently we set up the space of it on a floor of Kintetsu Department Store, one of the major department stores in downtown Osaka and display various irradiated products available in our daily life together with explanatory panels. We have been devising various attractions as efficient information transfer media so that even elementary-school kids understand the basic knowledge of radiation and irradiation technologies. The number of participants has increased year by year until more than 20,000 in recent years. We distributed questionnaires to the visitors for recent 3 years to inquire their status toward radiation and irradiated products as well as impression toward the displays. The survey results suggest that school education may contribute to establish the public image toward 'radiation' as well as mass media. (author)

  3. A critical look back over 15 years of the liberalization of the electricity markets

    Various analyses are now available concerning the successes and woes of the policies for the liberalization of the electricity market implemented around the world for some 15 years. The author offers us an overview of these documents, focusing on the results obtained when considered in light of the arguments put forward by those favouring liberalization. The problems observed more recently in the liberalized markets have certainly had local causes. They nevertheless all have several things in common. Their attributes (non-storability, inelasticity of demand, etc.), have made the electron a raw material (commodity) such as the markets are not very efficient. Solutions can always be found, but these solutions, each more ingenious than the last, all have a price. This is particularly the case for the household market segment, with the paradox here being that it is precisely at the very moment when experts are beginning to doubt the value (cost/profit) of extending competition to this market segment that the European Union decides to authorize such an extension. (authors)

  4. Analysis of Seismic Activity of the last 15 Years Nearby Puerto Rico and Caribbean Region.

    Huerta-Lopez, C. I.; Torres-Ortíz, D. M.; Fernández-Heredia, A. I.; Martínez-Cruzado, J. A.

    2015-12-01

    An earthquake catalog of the seismicity occurred during the last 15 years in the Caribbean region, nearby the vicinity of Puerto Rico Island (PRI) was compiled in order to capture the big picture of the regional seismic activity ratio and in particular at the epicentral regions of several historical and instrumentally recorded (during 2008-20015) large to moderate magnitude earthquakes occurred nearby PRI in onshore and offshore, which include the M6.4 earthquake of 01/13/2014, the largest earthquake recorded instrumentally nearby PRI. From the point of view of joint temporal-spatial distribution of epicenters, episodic temporal-spatial seismic activity is clearly seen as temporal-spatial concentrations during certain time intervals in different regions. These localized concentrations of epicenters that occur during certain time intervals in well localized/concentrated regions may suggest "seismic gaps" that shows no regular time interval, neither spatial pattern. In the epicentral region of the M6.4 01/13/2014 earthquake and the historical Mona Passage M7.5 earthquake of 10/11/1918, episodic concentrations in time and space of small magnitude earthquakes epicenters is evident, however do not show temporal pattern. Preliminary results of statistical analysis of an ongoing research in terms of the parameter b (Gutenberg-Richter relationship), and the Omori's law with the aim to relate the tectonic framework of the region (or sub-regions) such as structural heterogeneity stress are here presented/discussed.

  5. Revegetation dynamics after 15 years of rewetting in two extracted peatlands in Sweden

    S.A. Kozlov

    2016-02-01

    Full Text Available The restoration of extracted peatlands poses challenges with regard to their recolonisation by vegetation. The most significant problems are unstable water levels, destroyed propagule bank, and temperature fluctuations on bare peat surfaces. Rewetting is considered necessary for the re-establishment of peat-forming vegetation. Revegetation was investigated in a long-term field study at two rewetted extracted peatland sites in south-central Sweden, namely Västkärr (originally a lagg fen and Porla (originally a bog. Both sites were expanses of bare peat before rewetting. Rewetting procedures were applied in 1999 and strongly promoted plant colonisation. At Västkärr, colonisation started in the first year after rewetting, mostly by species that were not found during repeat vegetation surveys 15 years later. By 2014, Västkärr was a shallow lake surrounded by mesotrophic and eutrophic vegetation with species such as Carex rostrata, Lemna minor, Typha latifolia, Phalaris arundinacea and Phragmites australis. Revegetation of the Porla site was slower and started with Eriophorum vaginatum and Polytrichum spp. Sphagnum mosses appeared after six years and had established quite well after 13 years. A residual Sphagnum peat layer, inflowing surface water and groundwater provided spatially variable nutrient conditions. Sphagnum species and E. vaginatum established in nutrient-poor areas, while C. rostrata, P. australis and Eriophorum angustifolium colonised more nutrient-rich locations.

  6. Treatment of keloids with radiation therapy, which has been performed for 15 years in our clinic

    From 1988 to 2003, 108 true keloids of 58 patients were selected as follows. Keloids located on the breast, shoulder and upper arm. Keloids that were followed up more than 1.5 years after treatment. These keloids (keloids aging 0.5-40 years) were treated by radiation therapy or operation followed by postoperative radiation therapy. We devised a keloid score and used it for analysis of the therapeutic outcomes. The statistical difference was determined by two-sided Mann-Whitney's U test. A statistical difference of P<0.05 was considered significant. The analysis identified four factors that reduce the effect of radiation therapy to keloids. Keloids between 4-9 years old, keloids longer than 10 cm, irradiation dose under 20 Gy, keloids with contracture. Additionally, to treat keloids by radiation therapy, the results suggest that keloids with contracture require an operation to release tension, but keloids without contracture are responsive to radiation therapy, and it is not recommended to combine this with an operation. (author)

  7. Case of 15-year-old boy with left-hand homonymous hemianopsia

    Aim: In our study we analyse in detail the case of a 15- year-old boy with homonymous hemianopsia. The purpose of this study is to emphasize the importance of brain perfusion SPECT in differential diagnosis of neurological diseases and a possibility of incidence of serious children's brain ischemia. Methods: We analyse in detail the diagnostic method in detection and definitive diagnosis with stress an imaging methods. An integral part of the poster is picture documentation including 99mTc HMPAO SPECT using the double head camera PRISM 200 VP with LEHR collimator. The scintigraphic data were evaluated by the visual and semiquantitative analysis. Results: As early as at the beginning of the diagnostic method HMPAO SPECT of the brain was made and already here we drew attention to great probability of (luxurious) hyperperfusion in the ischemic zone in the right occipital lobe including the visual centre. Taking into consideration normal CT and MRI findings, an atypical course of herpetic encephalitis was considered and only on the second place an ischemic stroke. Conclusion: The case was concluded definitively as the state after an ischemic stroke in the area of arteria cerebri posterior l. dx. Apart from other facts mutation f V. Leiden - heterozygote and other congenital trombophilia state was found out - mutation of the gene for methyltetrahydrofolate reductase (heterozygote). Combination of two congenital trombophilic states could play its role in etiopatogenesis of the acute ischemic stroke. Brain perfusion SPECT helped significantly to determine the diagnosis

  8. Guillain Barré syndrome in a population less than 15 years old in Brazil

    Dias-Tosta Elza

    2002-01-01

    Full Text Available To know the impact of the Guillain Barré syndrome (GBS in the population less than 15 years old, after the eradication of poliomyelitis. Data bank from the program of epidemiological surveillance of acute flaccid palsies (AFP from the Fundação Nacional de Saúde were analyzed between 1990 -- 1996. From 3619 notifications of AFP there were 1678 GBS. GBS yearly incidence rates is 0.39-0.63 cases/100,000. No consistent seasonal variation existed or relationship to vaccines. Weakness at inclusion were, moderate 52.1%, severe in 47.9%, sixty days after 57.1% normal, 7.4% mild, 15.7% moderate, 10.4% with severe deficits, death in 5.4%. 67 (4.0% cases unknown. Death rates varies from 2.8% in southeast to 7.9% in the northeast. GBS was the most frequent cause of AFP. In spite of the severity of this disease being similar in the different regions, the outcome varies according to origin of the cases, possibly reflecting the economical conditions in those places.

  9. CERN openlab ‘open day’ marks 15 years of fruitful collaboration

    Andrew Purcell

    2016-01-01

    CERN openlab (see here) is organising an ‘open day’ event on 8-9 June 2016. The event will provide an opportunity to learn about CERN openlab’s work: collaborating with leading ICT companies and research institutes to accelerate the development of cutting-edge solutions for the worldwide LHC community, as well as for wider scientific research.   The event will take place at CERN in the main auditorium, as well as in the upstairs mezzanine area of the main building. It will feature both talks and posters on the achievements of diverse CERN openlab projects over the last year. There will also be hands-on technology demonstrations from companies working with CERN openlab, so that you too can discover the latest ICT innovations. The event marks 15 years since CERN openlab was established. “Since 2001, this unique public-private partnership has worked to ensure that members of CERN’s scientific community have access to the v...

  10. Nonossifying fibroma (metaphyseal fibrous defect) of the mandible in a 15-year-old boy.

    Mannan, Abul Ala; Singh, N Gopendro; Al-Waheeb, Salah; Taher, Taher N; Mohammed, Emad El Din El Din

    2015-06-01

    We describe a rare case of nonossifying fibroma of the mandible in a 15-year-old boy who presented with a left mandibular swelling. Conventional imaging showed an expansile radiolucent lesion involving the angle and the body of the left mandible. The lesion was curetted, and a miniplate was implanted at the excision site. Microscopic examination of the removed specimen revealed a cellular lesion characterized by a proliferation of uniform spindle-shaped cells in a vague but prominent storiform pattern, which represented the classic appearance of nonossifying fibroma. Three months later, radiography detected a fracture of the implantation plate. The area was re-explored with curettage of the soft tissue, which on microscopy demonstrated findings similar to the initial curettage findings. Follow-up radiology revealed satisfactory healing of the jaw, and no further recurrence was seen 2 years after the initial surgery. We present this case to highlight the importance of recognizing nonossifying fibroma in the mandible, which can be easily confused with more common mandibular lesions. PMID:26053991

  11. Sir Karl Popper (1902-1994): in memoriam, 15 years later.

    Notturno, Mark Amadeus

    2009-12-01

    September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Popper was recognized around the world as one of the 20th century's greatest philosophers of science and one of its most articulate and influential critics of Marxism and closed society. When he died, the contemporary wisdom among professional philosophers was that his philosophy was generally right-but somehow obsolete. Some commentators said that it was now obvious that scientific theories cannot be shown to be true. Others said that we had witnessed the end of history and that his critique of closed societies, while no doubt important in its day, had been fully assimilated into Western thinking and still had meaning, if at all, only for the democracies in transition that were trying to emerge from the former Soviet Union. But 15 years after his death, a look at science and society around the world gives us good reason to remember his philosophy. PMID:19819080

  12. Results of proximal gastric vagotomy over 1-5 years in a district general hospital.

    Makey, D A; Tovey, F I; Heald, R J

    1979-01-01

    One hundred and seventy-three underwent proximal gastric vagotomy for duodenal ulceration over a 6-year period. One hundred and fifteen of these have been followed up for 1-5 years. The operative mortality was nil and the result was satisfactory in 91 per cent. The incidence of side effects was small, notably that of dumping being 2.4 per cent and of diarrhoea, 3.6 per cent. Incidence of postoperative heartburn was reduced from 13 per cent to 4 per cent by the introduction of hepatic interposition. The incidence of recurrent ulceration was 5.1 per cent after an average interval of 2 years and that of new gastric ulceration 2.6 per cent after an average of 4 years. There were no recurrent ulcers in those who had peroperative Burge tests, although secretory studies showed no difference between those tested and those not tested. Most recurrences occurred in the earliest cases operated on before Burge testing was introduced and when only 2 cm of the lower oesophagus were exposed. PMID:420970

  13. [Coexistence of Jarcho-Levin syndrome, syringomyelia and osteoporosis in 15 years old boy].

    Torbus, Onufry; Jachimowicz, Magdalena; Pieta, Marcin; Głowacki, Jan; Karczewska, Krystyna; Skrzelewski, Stanisław

    2002-01-01

    Autosomally inherited Jarcho-Levin syndrome is an illness leading to death usually in the foetal, neonatal or infantile period or in early childhood. The children rarely survive to the age of adolescence. Hardly 130 cases of the syndrome were described up to now. There are two types of the syndrome: milder spondylocostal dysplasia (SCD) and more severe spondylothoracic dysplasia (STD)--the proper Jarcho-Levin syndrome. The authors present a case of coexistence of Jarcho-Levin syndrome with syringomyelia and osteoporosis in a 15 years old boy. His disease manifested itself in developmental anomaly of structure and segmentation of vertebrae, occult cervicothoracic spina bifida and characteristic crablike deformation of thorax. These anomalies led to kyphoscoliosis and considerable shortening of trunk as well as to the growth which increased the proportions of limbs length to the trunk and body height. The syndrome was accompanied by the syringomyelia in C5-Th1 segment and osteoporotic skeleton with significantly decreased bone density (in the L2-4 segment Z = -5.17). According to the best of our knowledge the presented case is the first description of the coexistence of Jarcho-Levin syndrome, syringomyelia and osteoporosis in world literature. The anomaly diagnosed as STD has also the features of SCD. The verification of the classification principles of Jarcho-Levin syndrome may take place in future basing on bigger number of observation and on genetics development. PMID:12715362

  14. Primary radiotherapy of prolactinomas. Eight- to 15-year follow-up

    Mehta, A.E.; Reyes, F.I.; Faiman, C.

    1987-07-01

    Eight women with amenorrhea, galactorrhea, and hyperprolactinemia, of whom six had macroadenomas and two had microadenomas, were treated with conventional (cobalt-60) external radiotherapy, and their progress was monitored for eight to 15 years. Normoprolactinemia was established in five of these patients after two to 13 years (median, nine years). A recurrence was treated surgically in one patient, and stable prolactin values and roentgenographic features have been maintained in two patients. Hypopituitarism has developed in only one patient to date, and no other complications of radiotherapy have been observed. These findings, together with the few previous reports on the long-term effects of radiotherapy on macroprolactinomas, have been compared with the long-term results following surgery or dopamine agonist therapy. The normalization of prolactin values is considerably delayed following radiotherapy compared with the other two therapeutic modalities. However, radiotherapy affords permanent normalization without recurrence in a larger percentage of patients than does surgery and avoids the considerable ongoing cost and inconvenience of daily drug ingestion. The long-term development of hypopituitarism appears to be an acceptably small risk of radiotherapy. Thus, conventional radiotherapy is an attractive treatment option, particularly for macroprolactinomas; adjunctive bromocriptine can be used while awaiting the longer-term benefits of radiotherapy.

  15. Primary radiotherapy of prolactinomas. Eight- to 15-year follow-up

    Eight women with amenorrhea, galactorrhea, and hyperprolactinemia, of whom six had macroadenomas and two had microadenomas, were treated with conventional (cobalt-60) external radiotherapy, and their progress was monitored for eight to 15 years. Normoprolactinemia was established in five of these patients after two to 13 years (median, nine years). A recurrence was treated surgically in one patient, and stable prolactin values and roentgenographic features have been maintained in two patients. Hypopituitarism has developed in only one patient to date, and no other complications of radiotherapy have been observed. These findings, together with the few previous reports on the long-term effects of radiotherapy on macroprolactinomas, have been compared with the long-term results following surgery or dopamine agonist therapy. The normalization of prolactin values is considerably delayed following radiotherapy compared with the other two therapeutic modalities. However, radiotherapy affords permanent normalization without recurrence in a larger percentage of patients than does surgery and avoids the considerable ongoing cost and inconvenience of daily drug ingestion. The long-term development of hypopituitarism appears to be an acceptably small risk of radiotherapy. Thus, conventional radiotherapy is an attractive treatment option, particularly for macroprolactinomas; adjunctive bromocriptine can be used while awaiting the longer-term benefits of radiotherapy

  16. University of the seas, 15 years of oceanographic schools on board of the Marion Dufresne

    Malaize, Bruno; Deverchere, Jacques; Leau, Hélène; Graindorge, David

    2015-04-01

    Since the first University at Sea, proposed by two French Universities (Brest and Bordeaux) in 1999, the R/V Marion Dufresne, in collaboration with the French Polar institute (IPEV), has welcome 12 oceanographic schools. The main objective of this educational and scientific program is to stimulate the potential interest of highly graduated students in scientific fields dealing with oceanography, and to broaden exchanges with foreign universities, strengthening a pool of excellence at a high international scientific level. It is a unique opportunity for the students to discover and to be involved in the work in progress of collecting scientific data on board of a ship, and to attend international research courses given by scientists involved in the cruise program. They also experience the final task of the scientific work by presenting their own training results, making posters on board, and writing a cruise report. For some University at Sea, students had also updated a daily journal, available on internet, hosted by the main institutions involved (as IPEV or EPOC, Bordeaux University). All this work is done in English, a common language to all the participants. An overview of these 15 years background experience will be presented, underlying the financial supports used, the logistic on board, as well as all the benefits acquiered by all former students, now in permanent positions in different international institutions.

  17. Hearing and loud music exposure in 14-15 years old adolescents

    Mario R Serra

    2014-01-01

    The participants consisted in 172 14-15 years old adolescents from a technical high school. Conventional and extended high frequency audiometry, transient evoked otoacoustic emissions and questionnaire on recreational habits were administered. Hearing threshold levels (HTLs were classified as: normal (Group 1, slightly shifted (Group 2, and significantly shifted (Group 3. The musical general exposure (MGE, from participation in recreational musical activities, was categorized in low, moderate, and high exposure. The results revealed an increase of HTL in Group 2 compared with Group 1 (P < 0.01, in Group 3 compared with Group 2 (P < 0.05 only in extended high frequency range, in Group 3 compared with Group 1 (P < 0.01. Besides, a decrease in mean global amplitude, reproducibility and in frequencies amplitude in Group 2 compared with Group 1 (P < 0.05 and in Group 3 compared with Group 1 (P < 0.05. A significant difference (P < 0.05 was found in Group 1′s HTL between low and high exposure, showing higher HTL in high exposure. The sound immission measured in nightclubs (107.8-112.2 dBA and PMPs (82.9-104.6 dBA revealed sound levels risky for hearing health according to exposure times. It demonstrates the need to implement preventive and hearing health promoting actions in adolescents.

  18. 78 FR 17413 - Announcement of the Award of an Urgent Single-Source Grant to the Center for Survivors of Torture...

    2013-03-21

    ...-Source Grant to the Center for Survivors of Torture in Dallas, TX AGENCY: Office of Refugee Resettlement... award of an urgent single-source grant to the Center for Survivors of Torture to provide mental health... Center for Survivors of Torture (CST) in Dallas, TX to ensure incoming refugee populations in Texas...

  19. Prevalence of malocclusion and orthodontic treatment needs among 12-15 years old school children of Udaipur, India

    Tak, Mridula; Nagarajappa, Ramesh; Sharda, Archana J; Asawa, Kailash; Tak, Aniruddh; Jalihal, Sagar; Kakatkar, Gauri

    2013-01-01

    Objective: The objective of the study is to assess the prevalence of malocclusion and orthodontic treatment needs among 12-15 years old school children of Udaipur, India. Materials and Methods: A cross-sectional descriptive survey was conducted among 887 subjects aged 12-15 years. The prevalence of malocclusion and orthodontic treatment needs was assessed using dental aesthetic index (World Health Organization, 1997). General information on demographic data was also recorded. Chi-square test,...

  20. Is physical activity associated with low-risk health behaviours among 15-year-old adolescents in Finland?

    Vuori, Mika; Kannas, Lasse; Villberg, Jari; Ojala, Kristiina; Tynjälä, Jorma; Välimaa, Raili

    2012-01-01

    Aims: To investigate the associations between physical activity and the pattern of risk health behaviour consisting of smoking, alcohol consumption, snuff (snus), cannabis and condom use among 15-year-old adolescents, taking their educational aspirations and family affluence into account. Methods: The data were collected in the Health Behaviour in School-aged Children (HBSC) study in Finland in 2006. Standardised questionnaires were issued at schools to a 15-year-old nationally representative...

  1. Self-reported medicine use among 11- to 15-year-old girls and boys in Denmark 1988-1998

    Holstein, Bjørn E; Holme Hansen, Ebba; Due, Pernille;

    2003-01-01

    large proportion of 11-15-year-olds reported medicine use during the past month. It was most common to take medicines for headache (used by 55% of 15-year-old girls and 36% of 15-year-old boys in 1998) and stomach ache (33% among 15-year-old girls in 1998). Pain reliever use was higher among girls than...... boys and this sex difference increased with age. There was an upward trend in reported medicine use from 1988 to 1998, in particular regarding medicine for stomach-ache among 13- and 15-year-old girls. A large proportion of girls were frequent users of medicine for headache, stomach-ache, and sleeping...... difficulties. CONCLUSION: A high proportion of 11-15-year-old girls and boys reported medicine use in relation to common health complaints. The proportion of users increased during the past decade. It is suggested that more information about medicine be built into health education programs in the future....

  2. Efficient extraction of zero-phonon-line photons from single nitrogen-vacancy centers in an integrated GaP-on-diamond platform

    Gould, Michael; Dadgostar, Shabnam; Hatami, Fariba; Fu, Kai-Mei C

    2016-01-01

    Scaling beyond two-node quantum networks using nitrogen vacancy (NV) centers in diamond is limited by the low probability of collecting zero phonon line (ZPL) photons from single centers. Here, we demonstrate GaP-on-diamond disk resonators which resonantly couple ZPL photons from single NV centers to single-mode waveguides. In these devices, the probability of a single NV center emitting a ZPL photon into the guided waveguide mode after optical excitation can reach 9%, due to a combination of resonant enhancement of the ZPL emission and efficient coupling between the resonator and waveguide. We verify the single-photon nature of the emission and experimentally demonstrate both high in-waveguide photon numbers and substantial Purcell enhancement for a set of devices. These devices may enable scalable integrated quantum networks based on NV centers.

  3. Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in Taiwan

    Huang Shang-Yi

    2011-09-01

    Full Text Available Abstract Background Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS are infrequently reported in the modern medical era. Method A retrospective study of hospitalized patients with hematological disease was conducted at National Taiwan University Hospital between January 1995 and December 2009. Results Clinical characteristics and outcomes with their associated radiographic and microbiological findings were analyzed. Forty-six patients with IFS and 64 patients with chronic non-invasive sinusitis were enrolled as comparsion. IFS developed more commonly in patients with acute myeloid leukemia (AML and with prolonged neutropenia (absolute neutrophil count less than 500/mm3 for more than 10 days (p Aspergillus flavus was the most common pathogen isolated (44%. Serum Aspergillus galactomannan antigen was elevated in seven of eleven patients (64% with IFS caused by aspergillosis but negative for all three patients with mucormycosis. Bony erosion and extra-sinus infiltration was found in 15 of 46 (33% patients on imaging. Overall, 19 of 46 patients (41.3% died within 6 weeks. Patients with disease subtype of AML (p = 0.044; Odds Ratio [OR], 5.84; 95% confidence interval [95% CI], 1.02-30.56 and refractory leukemia status (p = 0.05; OR, 4.27; 95% CI, 1.003-18.15 had worse prognosis. Multivariate analysis identified surgical debridement as an independent good prognostic factor (p = 0.047 in patients with IFS. Conclusions Patients of AML with prolonged neutropenia (> 10 days had significantly higher risk of IFS. Early introduction of anti-fungal agent and aggressive surgical debridement potentially decrease morbidity and mortality in high risk patients with IFS.

  4. Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years.

    Hassan-Smith, Zaki K

    2012-04-01

    Historically, Cushing\\'s disease (CD) was associated with a 5-yr survival of just 50%. Although advances in CD management have seen mortality rates improve, outcome from transsphenoidal surgery (TSS), the current first-line treatment, varies significantly between centers.

  5. Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience

    Rampelli, S. K.; Rajesh, N. G.; Srinivas, B. H.; Harichandra Kumar, K. T.; Swaminathan, R. P.; Priyamvada, P. S.

    2016-01-01

    There is limited data on the etiology, clinical and histopathological spectrum and outcomes of crescentic glomerulonephritis (CrGN) in adult Indian population. This prospective study was done to evaluate the etiology, clinicohistological patterns and predictors of outcome of CrGN in South Indian population. All the patients received standard protocol based immunosuppression in addition to supportive care. Immune-complex glomerulonephritis (ICGN) was the most common etiology (n = 31; 77.5%) followed by pauci-immune glomerulonephritis (PauciGN; n = 8; 20%) and anti-glomerular basement membrane disease (n = 1; 2.5%). The most common etiology of ICGN was IgA nephropathy (n = 11; 27.5%) followed by lupus nephritis (n = 7; 17.5%) and post-infectious glomerulonephritis (PIGN) (n = 7; 17.5%). The patients with PauciGN were significantly older compared to those with ICGN (44.5 ± 15 years vs. 31.8 ± 11 years; P = 0.01). The patients with PauciGN presented with significantly higher serum creatinine (9.7 ± 4.4 vs. 6.6 ± 3.3 mg/dl; P = 0.03). The histopathologic parameters of ICGN and PauciGN were comparable except for a higher proportion of sclerosed glomeruli in ICGN. At the end of 3 months follow-up, only two patients went into complete remission (5.4%). Majority of the patients had end-stage renal failure (48.6%) and were dialysis dependent and seven patients (18.9%) expired. There was no signifi difference in the renal survival (10.9 ± 1.9 vs. 9.6 ± 3.3 months) or patient survival (17.5 ± 2.1 vs. 17.3 ± 4.3 months). The parameters associated with adverse outcomes at 3 months were hypertension (odds ratio [OR]: 0.58; confidence interval [CI]: 0.36–0.94), need for renal replacement therapy (OR: 0.19; CI: 0.04–0.9), serum creatinine at admission (P = 0.019), estimated glomerular filtration rate (P = 0.022) and percentage of fibrocellular crescents (P = 0.022). PMID:27512296

  6. A 15 year legacy of cloud and atmosphere observations in Barrow, Alaska

    Shupe, M.

    2012-12-01

    For the past 15 years, the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) Program has operated the North Slope of Alaska (NSA) atmospheric observatory in Barrow, Alaska. Barrow offers many valuable perspectives on the Arctic environment that complement observations at lower latitudes. Unique features of the Arctic region include cold and dry atmospheric conditions, strong annual variability in sun light, a seasonally high-reflective surface, and persistent clouds that involve mixed-phase processes. ARM's ultimate objective with its flagship observatory at the northernmost point in U.S. territory is to provide measurements that can be used to improve the understanding of these atmospheric physical and radiative properties and processes such that they can be better represented in climate models. The NSA is the most detailed and long-lasting cloud-radiation-atmosphere observatory in the Arctic, providing continuous, sophisticated measurements of climate-relevant parameters. Instrument suites include active radars and lidars at various frequencies, passive radiometers monitoring radiation in microwave, infrared, visible and ultraviolet wavelengths, meteorological towers, and sounding systems. Together these measurements are used to characterize many of the important properties of clouds, aerosols, atmospheric radiation, dynamics, thermodynamics, and the surface. The coordinated nature of these measurements offers important multi-dimensional insight into many fundamental processes linking these different elements of the climate system. Moreover, the continuous operations of the facility support these observations over the full diurnal cycle and in all seasons of the year. This presentation will highlight a number of important studies and key findings that have been facilitated by the NSA observations during the first 15 years in operation. Some of these include: a thorough documentation of clouds, their occurrence frequency, phase, microphysical

  7. Selected atherosclerosis risk factors in youth aged 13–15 years 

    Agnieszka Michalska

    2012-09-01

    Full Text Available Introduction:The high frequency of cases of circulatory system conditions in Europe and other countries around the world requires scientific research to define risk factors of early atherosclerotic changes. The aim of the present study was to define which students are at danger of developing atherosclerosis by means of measuring cholesterol and triglyceride levels in blood as well as defining the correlation between atherosclerosis risk factors and arterial blood pressure, physical fitness and efficiency of the subjects.Material/Methods:The research covered 167 students of Public Junior High School ¹1 in Biala Podlaska aged 13–15 years. Accutrend GCT was employed to define the levels of total cholesterol and triglycerides in the screen test. Those students who were found to have increased values of biochemical parameters of capillary blood were subjected to additional blood tests aiming to define complete lipid profile of venous blood. The blood pressure in subjects was tested three times. The Moderate-to-Vigorous Physical Activity (MVPA test, suggested by American authors, was employed to define physical activity in subjects. EUROFIT was employed to define physical efficiency.Results:Among the 167 subjects there were found 42 students (25.1�20whose lipid level in capillary blood proved to be increased. Full lipid profile tests proved that 16 students (9.6�20had increased blood lipid levels; those subjects constituted the risk group. Subjects in the risk group were characterized by lower levels of physical activity and physical efficiency compared to subjects with normal blood lipid level. Moreover, the frequency of hypertension was greater in risk group subjects compared to subjects with normal blood lipid levels.Inferences:Students diagnosed with atherosclerosis risk factors require observation and early prophylactics by adopting habits of healthy physical activity.

  8. Average daily nitrate and nitrite intake in the Belgian population older than 15 years.

    Temme, E H M; Vandevijvere, S; Vinkx, C; Huybrechts, I; Goeyens, L; Van Oyen, H

    2011-09-01

    The aim of this study was to assess the dietary intake of nitrate and nitrite in Belgium. The nitrate content of processed vegetables, cheeses and meat products was analysed. These data were completed by data from non-targeted official control and from the literature. In addition, the nitrite content of meat products was measured. Concentration data for nitrate and nitrite were linked to food consumption data of the Belgian Food Consumption Survey. This study included 3245 respondents, aged 15 years and older. Food intakes were estimated by a repeated 24-h recall using EPIC-SOFT. Only respondents with two completed 24-h recalls (n=3083) were included in the analysis. For the intake assessment, average concentration data and individual consumption data were combined. Usual intake of nitrate/nitrite was calculated using the Nusser method. The mean usual daily intake of nitrate was 1.38 mg kg(-1) bodyweight (bw) day(-1) and the usual daily intake at the 97.5 percentile was 2.76 mg kg(-1) bw day(-1). Exposure of the Belgian population to nitrate at a mean intake corresponded to 38% of the ADI (while 76% at the 97.5 percentile). For the average consumer, half of the intake was derived from vegetables (especially lettuce) and 20% from water and water-based drinks. The average daily intake of nitrate and nitrite from cheese and meat products was low (0.2% and 6% of the ADI at average intake, respectively). Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate. Whether this is beneficial or harmful must be further assessed. PMID:21728895

  9. Sociodemographic correlates of food habits among school adolescents (12–15 year in north Gaza Strip

    Shi Zumin

    2009-06-01

    Full Text Available Abstract Background There is little information about meal patterns and food consumption of adolescents in Palestine. The objective of this study was to describe the association between sociodemographic factors and food intake, and meal patterns among Palestinian school adolescents (12–15 year in North Gaza Strip. Methods A cross-sectional study was conducted in 2002 comprising 944 subjects in 10 schools in Gaza city, Jabalia village and Jabalia refugee camp. Self-administered questionnaires were filled in by students and parents to obtain data on frequency of meals, food intake and sociodemographic characteristics. Results High household socioeconomic status (SES was associated with the increased number of meals and the increased intakes of many nutritious foods such as; animal food items, fruits and vegetables and dairy foods. The percentage of adolescents having breakfast daily of high and low SES was 74.5% vs 55% in boys and 65.6% vs 45% in girls. The percentage of girls with refugee status who had lunch was higher (90.2% compared to the local citizen girls (83.9%, (p = 0.03. Girls were less likely to skip daily lunch (OR = 0.55, 95% CI = 0.36–0.87, p = 0.01 compared to boys. Risk of skipping lunch was three times higher among adolescents living in the village compared to Gaza well-off area (OR = 3.3, 95% CI = 1.72–6.31, p Conclusion Meal skipping is common, particularly among those of low SES and the intakes of many nutritious foods such as animal food items, fruits and vegetables and dairy foods seem to be low among adolescents of low SES. The results of this study could be used as an important base-line for future monitoring of the nutritional situation of adolescents.

  10. Population Based National Tuberculosis Prevalence Survey among Adults (>15 Years) in Pakistan, 2010–2011

    Qadeer, Ejaz; Fatima, Razia; Yaqoob, Aashifa; Tahseen, Sabira; Ul Haq, Mahboob; Ghafoor, Abdul; Asif, Muhammad; Straetemans, Masja; Tiemersma, Edine W.

    2016-01-01

    Background We aimed to determine the prevalence of pulmonary tuberculosis (TB) amongst the adult population in 2010–2011 in Pakistan. Method A nationwide cross-sectional survey with multistage cluster sampling was conducted among adults (≥15 years) in 95 clusters in 2010–2011. All consenting participants were screened for cough and by chest X-ray. Participants with presumptive TB submitted two sputum samples for smear microscopy, culture, and molecular testing if needed. The TB prevalence estimates were adjusted for missing data and the cluster design. Result Of 131,329 eligible individuals, 105,913 (81%) participated in the survey, of whom 10,471 (9.9%) were eligible for sputum examination. We found 341 bacteriologically positive TB cases of whom 233 had sputum smear-positive TB. The adjusted prevalence estimates for smear and bacteriologically positive TB were 270/100,000 (95% confidence interval (CI) 217–323), and 398/100,000 (95% CI 333–463), respectively. Only 61% of the diagnosed TB cases screened positive on symptoms (cough >2wks), whereas the other TB cases were detected based on X-ray abnormalities. The TB prevalence increased with age and was 1.8 times higher among men than women. The prevalence-to-notification ratio of smear-positive TB was 3.1 (95% CI 2.5–3.7), was higher among men than women, and increased with age. Conclusion Our data suggest that there is under-detection and/or -notification of TB, especially among men and elderly. TB control should be strengthened specifically in these risk groups. X-ray examination should be combined with symptom screening to enhance case detection. PMID:26863617

  11. Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort.

    Wiersma, D; Nienhuis, F J; Slooff, C J; Giel, R

    1998-01-01

    Data are presented on the 15-year natural course of schizophrenia and other nonaffective functional psychoses in a cohort of 82 first-contact cases from a circumscribed area in the Netherlands. The subjects were suffering from functional psychosis with International Classification of Diseases-Ninth Revision (ICD-9) diagnoses 295, 297, or 298.3-9 (broad definition of schizophrenia) on entry. Standardized assessments of psychopathology, psychological impairments, negative symptomatology, social disability, and use of mental healthcare were used. The study reveals a pattern of chronicity and relapses with a high risk of suicide: Two-thirds of the subjects had at least one relapse and after each relapse 1 of 6 subjects did not remit from the episode; 1 of 10 committed suicide; and 1 of 7 had at least one episode with affective psychotic symptoms that started on average 6 years after the onset of the schizophrenic disorder. Diagnoses were reclassified in five patients, according to DSM-III-R criteria for a bipolar disorder. The predictive power--in terms of time in psychosis and in partial or full remission--of demographic, illness, and treatment variables at onset of the illness was very limited. Insidious onset and delays in mental health treatment are risk factors that predict a longer duration of first or subsequent episodes. The importance of mental health treatment in regard to outcome is probably subject to change because an early warning and intervention strategy could prevent further damage and deterioration. Our data support the need for an adequate relapse prevention program as a priority for our mental health services. PMID:9502547

  12. A 15-Year-Old Male Baseball Player With a Mass in the Brachialis Muscle.

    Golub, Ivan J; Garcia, Roberto A; Wittig, James C

    2016-05-01

    A 15-year-old boy presented with a mass in his right arm after suffering a minor injury playing baseball. He had been diagnosed with a hematoma. There was no other outstanding medical/surgical history. Magnetic resonance images showed a heterogeneous mass arising from the brachialis muscle that mainly enhanced peripherally with extremely scant internal nodular enhancement. Core needle biopsy cells were positive for CD31 and CD34, markers for atypical endothelial cells, as well as MIB-1 and p53. The final diagnosis was an angiosarcoma of the brachialis muscle. Pediatric angiosarcoma, particularly within deep tissue, is exceedingly rare. Histological and immunohistochemical modalities led to the diagnosis. Magnetic resonance images suggested a mass with a large cystic/hemorrhagic space that could have been misconstrued as a hematoma had there been absolutely no nodular or septal enhancement. The patient underwent neoadjuvant chemotherapy and radiation before undergoing limb-sparing surgery that included resection of the mass with the brachialis muscle and short head of the biceps muscle. Neoadjuvant treatment was deemed successful due to a drastic reduction in the size of the tumor and 95% tumor necrosis. The patient was disease free 2 years postoperatively. There had been no local/systemic recurrences. He was pain free, had normal elbow function, and had returned to playing baseball. It is important to be extremely suspicious when a patient presents with a hemorrhagic, painless, enlarging mass after sustaining minor trauma. A careful and meticulous biopsy must be completed to achieve the correct diagnosis. Magnetic resonance imaging with gadolinium is recommended for evaluation because these masses can be often misinterpreted as hematomas. [Orthopedics. 2016; 39(3):e545-e548.]. PMID:27045482

  13. Post–Endoscopic Retrograde Cholangiopancreaticography complications in liver transplanted patients, a single-center experience

    Ambrus, R B; Svendsen, Lars Bo; Hillingsø, J G;

    2015-01-01

    BACKGROUND: Complications in the biliary tract occur in 5%-30% after liver transplantation and the main part of the complications is successfully managed with endoscopic retrograde cholangiopancreaticography (ERCP). The incidence and risk factors for post-ERCP complications in liver transplantation...... patients are not well described. Our objective was to define the frequency of post-ERCP complications in liver transplantation patients at the Abdominal Center, Rigshospitalet, the only Liver Transplantation Center in Denmark. METHODS: Retrospective study of all ERCPs performed in liver transplantation...... cholangitis occurred after two procedures, respectively. Multivariate analysis concerning overall complications identified biliary sphincterotomy (p = 0.006) and time since liver transplantation within 90 days postoperatively (p = 0.044) as risk factors for post-ERCP complications. Specifically concerning...

  14. Para onde caminham os Cieps? Uma análise após 15 anos Where are the Cieps headed? An analysis after 15 years

    Ana Maria Cavaliere

    2003-01-01

    Full Text Available O trabalho descreve aspectos da realidade dos Centros Integrados de Educação Pública - Cieps -, da rede estadual do Rio de Janeiro, baseando-se em pesquisa, realizada em 2001, com 50 diretores. Estabelece comparações com a época em que essas escolas foram implantadas sob a forma de programa especial de governo, levando em conta o funcionamento em horário integral, as dificuldades de gestão, as atividades oferecidas, a quantidade de alunos por escola, a utilização e conservação dos espaços. Conclui que a variedade dos níveis de ensino abarcados e a convivência de diferentes regimes horários num mesmo estabelecimento demonstram a vocação ainda pouco definida de tais escolas. A opinião dos gestores sobre o trabalho desenvolvido nos Cieps que mantiveram o horário integral mostra que eles o consideram, muitas vezes, assistencialista, embora essa definição seja vaga e muito variada. Após mais de 15 anos de existência, a tendente municipalização do ensino fundamental e a pressão por vagas no ensino médio parecem ser os maiores entraves para a manutenção dessas escolas segundo seu projeto original.Based on research done by 50 principals of Integrated Centers for Public Education, the Cieps, of the Rio de Janeiro state educational system, this article describes aspects of reality in schools in the year 2001. Comparisons are made with the time when they were implemented as a special government program, taking into consideration their functioning on a full time basis, their management difficulties, the activities offered, the number of students per school and the utilization and conservation of the facilities. It concludes that the variety in levels of teaching which they encompass and the concurrence of different time schedules in a single establishment demonstrate that the purpose of these schools is still poorly defined. The managers' opinions about the work developed in the Cieps which maintained a full time schedule

  15. Clinical Characteristics of Bowel Obstruction in Southern Iran; Results of a Single Center Experience

    Majid Akrami; Ali Ghaeini Hesarooeih; Maryam Barfei; Vahid Zangouri; Zahra Alborzi

    2015-01-01

    Objective: To determine the epidemiological, clinical, laboratory characteristics as well as outcome of 411 patients with bowel obstruction in Southern Iran. Methods: This was a cross-sectional study being performed in Shahid Faghihi hospital of Shiraz between 2006 and 2012. We reviewed the medical charts of the 411 patients with initial diagnosis of bowel obstruction who were admitted to our center during the study period. The patients’ demographic, clinical and laboratory findings as wel...

  16. Short-term Outcome of Open Appendectomy in Southern Iran: A Single Center Experience

    Shahram Bolandparvaz; Fariborz Ghaffarpasand; Hamid Reza Abbasi; Armin Akbarzadeh; Alireza Manafi; Parisa Javidi Parsijani; Shahram Paydar

    2013-01-01

    Objectives: To evaluate the short-term outcome of open appendectomy, the rate of negative appendectomy as well as pathology reports after surgery in patients with suspected acute appendicitis.Methods: This was a retrospective cross-sectional study being performed in Nemazee hospital affiliated with Shiraz University of Medical Science during a 2-year period between 2008 and 2010. The medical records of all consecutive patients who underwent open appendectomy in our center due to acute appendi...

  17. Prophylactic Pancreatic Stent Placement for Endoscopic Duodenal Ampullectomy: A Single-Center Retrospective Study

    Chang, Woo Ik; Min, Yang Won; Yun, Hwan Sic; Lee, Kwang Hyuck; Lee, Jong Kyun; Lee, Kyu Taek; Rhee, Poong-Lyul

    2013-01-01

    Background/Aims We investigated the efficacy of prophylactic pancreatic stent placement for preventing postprocedure pancreatitis in patients undergoing endoscopic papillectomy. Methods This retrospective study included 82 consecutive patients who underwent endoscopic papillectomy for benign ampullary neoplasm at Samsung Medical Center between August 2002 and June 2011. The patients were subdivided into two groups, namely, those who received prophylactic pancreatic stent placement and those w...

  18. Congenital cystic lesions of the lungs: The perils of misdiagnosis - A single-center experience

    V Shankar Raman

    2015-01-01

    Full Text Available Background: A majority of cystic lesions in the western world are detected antenatally, whereas, the diagnosis in our setup occurs once the child becomes symptomatic. Surgical management is primarily dictated by the presence of symptoms, recurrent infection, and rarely by the potential risk of malignant transformation. Materials and Methods: A retrospective analysis was carried out on all consecutive patients with cystic lung lesions managed at our center from January 2000 through June 2011 for antenatal diagnosis, presentation, diagnostic modalities, treatment, and complications. Results: Forty cystic lung lesions were identified. Only 8% were antenatally detected. Out of 40, the final diagnosis was congenital cystic adenomatoid malformation in 19, congenital lobar emphysema in 11, and bronchogenic cysts and pulmonary sequestration in five each. Of these, 20% had received a course of prior antitubercular therapy and 30% had an intercostal drain inserted prior to referral to our center. Postoperative morbidity in the form of bronchopleural fistula, pneumothorax, and non-expansion of the residual lung was noted in 10% of the patients. Conclusion: Antenatal diagnosis of these lesions is still uncommon in third world countries. Prior to referral to a pediatric surgical center a large number of patients received antitubercular drugs and an intercostal drain insertion, due to incorrect diagnosis.

  19. Determinants of Subclinical Vitamin A Deficiency among children 1-5 years in a rural community of Jammu

    Shivali Suri

    2015-06-01

    Full Text Available Background: The burden of sub-clinical vitamin A deficiency (VAD, as evident by serum retinol levels, is huge (62% among preschool children in India. Sub-clinical VAD increases children’s' susceptibility to infections, reduces physical growth and decreases the ability to survive from serious illnesses. Aims & Objectives: To assess the burden of subclinical VAD and study the various risk factors associated with it among children 1-5 years of age. Material Methods: A cross sectional community based study was conducted among 750 children selected from 15 villages adopting multistage random sampling from January to December 2011. Heller Keller International Food Frequency Questionnaire (HKI- FFQ was used to assess intakes of 28 food-items including vitamin A rich foods for the past 7 days. Various risk factors like socio-demographic profile, dietary pattern, vitamin A supplementation and breast feeding patterns were also studied. Results: Twelve of the fifteen cluster villages studied were found to be at risk of subclinical VAD. 30.6 % of study subjects had not received even a single dose of Vitamin A. Almost one-third of the subjects had not been breast-fed for the recommended 6 months. Age and socio-economic status were significantly associated with the risk of sub-clinical VAD. Among the dietary factors, consumption of purely vegetarian foods and intake of green leafy vegetables less than thrice a week were significantly associated with enhanced risk of sub-clinical VAD. Conclusion: Sub Clinical VAD is a public health problem of wide-spread importance.   Dietary diversification along with enhanced coverage of Vitamin A supplementation can tackle the problem of subclinical VAD

  20. Hospital-based, prospective, multicentre surveillance to determine the incidence of intussusception in children aged below 15 years in Germany

    Bissantz Kathrin

    2011-03-01

    Full Text Available Abstract Background A new vaccine against Rotavirus (RV gastroenteritis was introduced in Germany in 2006. In 1997 the first RV vaccine was withdrawn due to an increased incidence in intussusception (IS. Thus, an accurate estimation of the incidence of IS is important for post-licensure surveillance. Methods IS-Data were obtained from the 'Erhebungseinheit für seltene pädiatrische Erkrankungen Deutschland' (ESPED, German surveillance unit for rare pediatric diseases collaborations' central register where all cases of intussusception in Germany for the years 2006 and 2007 are collected (n = 1200. In order to obtain an unbiased estimate of the incidence, it is necessary to determine the population under risk out of which these cases originated, and the proportion of real cases not reported to the registry (underreporting. In order to assess underreporting, a random sample of 31 hospitals was re-assessed by an outside reviewer. The estimation of incidence was done using a single Maximum-Likelihood (ML estimator based on data from both the registry and the sample. Results The uncorrected observed incidence was calculated to be 26.6/100,000 child-years for children below 1 year old, 23.8 for those below 2 years old, and 5.2 for those below 15 years old. The review revealed a mean reporting quota of about 41% and the ML approach yielded an incidence of 51.5/100,000 child-years (95%CI [41.7;61.1] for children below 2 years of age. Conclusions While substantial under-reporting led to very conservative estimates of the IS incidence, the approach described here allows an accurate estimation of IS incidence including corresponding confidence bands. Therefore, ML estimation is a straightforward instrument to derive stable, unbiased estimates in epidemiological studies with incomplete data.

  1. Type and cause of liver disease in Korea: single-center experience, 2005-2010

    Lee, Sang Soo; Byoun, Young-Sang; Jeong, Sook-Hyang; Kim, Yeo Myung; Gil, Ho; Min, Bo-young; Seong, Mun Hyuk; Jang, Eun Sun; Kim, Jin-Wook

    2012-01-01

    Background/Aims The aim of this study was to describe the types and causes of liver disease in patients from a single community hospital in Korea between April 2005 and May 2010. Methods A cohort of patients who visited the liver clinic of the hospital during the aforementioned time period were consecutively enrolled (n=6,307). Consistent diagnostic criteria for each liver disease were set by a single, experienced hepatologist, and the diagnosis of all of the enrolled patients was confirmed b...

  2. Centering Ability and Influence of Experience When Using WaveOne Single-File Technique in Simulated Canals

    Mathieu Goldberg

    2012-01-01

    Full Text Available Introduction. WaveOne is a single endodontic instrument that reciprocates with a dedicated motor to shape root canal systems. The present study assessed the centering ability of this simplified protocol along with the effect of experience in simulated plastic canals. Methods. One experienced operator shaped two groups of simulated canals. Groups 1 and 3 each comprised 30 blinded L-shaped canals or S-shaped canals, respectively. Photographs were taken before and after shaping and digitally assessed centering after superimposition of the pictures. Time of shaping, number of passes, canal aberrations, and instrument degradation were recorded. In group 2 shaping was done on 30 blinded L-shaped canals by 30 different students with no prior experience with WaveOne. Results. All three groups yielded satisfactory, reproducible shaping. Centering ratios were low and homogeneous in all groups, with no significant differences between the experienced operator and the students. Apical transportation values were very low (≤0.138 mm with no instances of blockage or separation. The average shaping time was short (43 to 101,6 sec. Conclusions. Within the limits of the study, the WaveOne instrument had excellent centering ability with a low risk of fracture or blockage and a short shaping time, regardless of the operator’s level of experience.

  3. Two- and Three-Electron Oxidation of Single-Site Vanadium Centers at Surfaces by Ligand Design.

    Skomski, Daniel; Tempas, Christopher D; Cook, Brian J; Polezhaev, Alexander V; Smith, Kevin A; Caulton, Kenneth G; Tait, Steven L

    2015-06-24

    Rational, systematic tuning of single-site metal centers on surfaces offers a new approach to increase selectivity in heterogeneous catalysis reactions. Although such metal centers of uniform oxidation states have been achieved, the ability to control their oxidation states through the use of carefully designed ligands had not been shown. To this end, tetrazine ligands functionalized by two pyridinyl or pyrimidinyl substituents were deposited, along with vanadium metal, on the Au(100) surface. The greater oxidizing power of the bis-pyrimidinyltetrazine facilitates the on-surface redox formation of V(3+), compared to V(2+) when paired with the bis-pyridinyltetrazine, as determined by X-ray photoelectron spectroscopy. This demonstrates the ability to control metal oxidation states in surface coordination architectures by altering the redox properties of organic ligands. The metal-ligand complexes take the form of one-dimensional polymeric chains, resolved by scanning tunneling microscopy. The chain structures in the first layer are very uniform and are based on the same quasi-square-planar coordination geometry around single-site V with either ligand. Formation of a different, dimer structure is observed in the early stages of the second layer formation. These systems offer new opportunities in controlling the oxidation state of single-site transition metal atoms at a surface for new advances in heterogeneous catalysts. PMID:26029790

  4. Sudden, unexpected death of a 15-year-old boy due to pancarditis

    Osculati, Antonio; Visonà, Silvia Damiana; Ventura, Francesco; Castelli, Francesca; Andrello, Luisa

    2016-01-01

    Abstract Background: Generally, rheumatic heart disease is, today, sporadic in developed countries, even though it continues to be a major health hazard in the developing ones. It is also a very rare cause of sudden unexpected death. We report a case of a 15-year-old boy who suddenly died at home. Since 3 days he had presented fever and chest pain. The family physician had diagnosed bronchitis and treated the boy with amoxicillin. Methods: Seven hours after death, a forensic autopsy were performed . Before the autopsy, anamnesis and some circumstantial data were collected from the boy's parents. During the autopsy, samples for histological, toxicological and molecular examinations were collected. The samples for the histology (brain, hypophysis, heart and pericardium, lungs, spleen, liver, kidney, adrenal glands) were formalin fixed and paraffin embedded. Each section was stained with Hematoxylin-Eosin. Immunostaining was also performed, with anti-CD 68, anti-CD3, anti-CD 20, anti-myeloperoxidase. Microbiological cultures were performed on cardiac blood, myocardium, pericardial effusion and cerebrospinal fluid samples collected during autopsy. Blood specimens were also processed through PCR, in order to reveal the presence of Enteroviruses, Chickenpox virus, Epstein Barr virus. Also chemical-toxicological examinations for the detection of the main medications and drugs were performed on blood samples. Results: The anamnesis, collected before the autopsy, revealed an acute pharyngitis few weeks before. The autopsy, and the following histological and immunochemical examinations suggested an immunological etiology. The immunohistochemistry, showing a strong positivity of antiCD68 antibodies, integrated with clinical-anamnestic information, leads to hypothesize a rheumatic carditis. Conclusion: In light of this case, at least 3 main messages of great importance for the clinician can be deduced. First, an accurate anamnesis collected by the family physician could have

  5. Marine mammal strandings and environmental changes: a 15-year study in the St. Lawrence ecosystem.

    Truchon, Marie-Hélène; Measures, Lena; L'Hérault, Vincent; Brêthes, Jean-Claude; Galbraith, Peter S; Harvey, Michel; Lessard, Sylvie; Starr, Michel; Lecomte, Nicolas

    2013-01-01

    Understanding the effects of climatic variability on marine mammals is challenging due to the complexity of ecological interactions. We used general linear models to analyze a 15-year database documenting marine mammal strandings (1994-2008; n = 1,193) and nine environmental parameters known to affect marine mammal survival, from regional (sea ice) to continental scales (North Atlantic Oscillation, NAO). Stranding events were more frequent during summer and fall than other seasons, and have increased since 1994. Poor ice conditions observed during the same period may have affected marine mammals either directly, by modulating the availability of habitat for feeding and breeding activities, or indirectly, through changes in water conditions and marine productivity (krill abundance). For most species (75%, n = 6 species), a low volume of ice was correlated with increasing frequency of stranding events (e.g. R(2)adj = 0.59, hooded seal, Cystophora cristata). This likely led to an increase in seal mortality during the breeding period, but also to increase habitat availability for seasonal migratory cetaceans using ice-free areas during winter. We also detected a high frequency of stranding events for mysticete species (minke whale, Balaenoptera acutorostrata) and resident species (beluga, Delphinapterus leucas), correlated with low krill abundance since 1994. Positive NAO indices were positively correlated with high frequencies of stranding events for resident and seasonal migratory cetaceans, as well as rare species (R(2)adj = 0.53, 0.81 and 0.34, respectively). This contrasts with seal mass stranding numbers, which were negatively correlated with a positive NAO index. In addition, an unusual multiple species mortality event (n = 114, 62% of total annual mortality) in 2008 was caused by a harmful algal bloom. Our findings provide an empirical baseline in understanding marine mammal survival when faced with climatic variability. This is a promising

  6. Drivers of Productivity Trends in Cork Oak Woodlands over the Last 15 Years

    Maria João Santos

    2016-06-01

    Full Text Available Higher biodiversity leads to more productive ecosystems which, in turn, supports more biodiversity. Ongoing global changes affect ecosystem productivity and, therefore, are expected to affect productivity-biodiversity relationships. However, the magnitude of these relationships may be affected by baseline biodiversity and its lifeforms. Cork oak (Quercus suber woodlands are a highly biodiverse Mediterranean ecosystem managed for cork extraction; as a result of this management cork oak woodlands may have both tree and shrub canopies, just tree and just shrub canopies, and just grasslands. Trees, shrubs, and grasses may respond differently to climatic variables and their combination may, therefore, affect measurements of productivity and the resulting productivity-biodiversity relationships. Here, we asked whether the relationship between productivity and climate is affected by the responses of trees, shrubs, and grasses in cork oak woodlands in Southern Portugal. To answer this question, we linked a 15-year time series of Enhanced Vegetation Index (EVI derived from Landsat satellites to micrometeorological data to assess the relationship between trends in EVI and climate. Between 2000 and 2013 we observed an overall decrease in EVI. However, EVI increased over cork oaks and decreased over shrublands. EVI trends were strongly positively related to changes in relative humidity and negatively related to temperature. The intra-annual EVI cycle of grasslands and sparse cork oak woodland without understorey (savannah-like ecosystem had higher variation than the other land-cover types. These results suggest that oaks and shrubs have different responses to changes in water availability, which can be either related to oak physiology, to oaks being either more resilient or having lagged responses to changes in climate, or to the fact that shrublands start senesce earlier than oaks. Our results also suggest that in the future EVI could improve because the

  7. Marine mammal strandings and environmental changes: a 15-year study in the St. Lawrence ecosystem.

    Marie-Hélène Truchon

    Full Text Available Understanding the effects of climatic variability on marine mammals is challenging due to the complexity of ecological interactions. We used general linear models to analyze a 15-year database documenting marine mammal strandings (1994-2008; n = 1,193 and nine environmental parameters known to affect marine mammal survival, from regional (sea ice to continental scales (North Atlantic Oscillation, NAO. Stranding events were more frequent during summer and fall than other seasons, and have increased since 1994. Poor ice conditions observed during the same period may have affected marine mammals either directly, by modulating the availability of habitat for feeding and breeding activities, or indirectly, through changes in water conditions and marine productivity (krill abundance. For most species (75%, n = 6 species, a low volume of ice was correlated with increasing frequency of stranding events (e.g. R(2adj = 0.59, hooded seal, Cystophora cristata. This likely led to an increase in seal mortality during the breeding period, but also to increase habitat availability for seasonal migratory cetaceans using ice-free areas during winter. We also detected a high frequency of stranding events for mysticete species (minke whale, Balaenoptera acutorostrata and resident species (beluga, Delphinapterus leucas, correlated with low krill abundance since 1994. Positive NAO indices were positively correlated with high frequencies of stranding events for resident and seasonal migratory cetaceans, as well as rare species (R(2adj = 0.53, 0.81 and 0.34, respectively. This contrasts with seal mass stranding numbers, which were negatively correlated with a positive NAO index. In addition, an unusual multiple species mortality event (n = 114, 62% of total annual mortality in 2008 was caused by a harmful algal bloom. Our findings provide an empirical baseline in understanding marine mammal survival when faced with climatic variability. This is a

  8. Postchemotherapy Retroperitoneal Lymph Node Dissection in Patients With Nonseminomatous Testicular Cancer: A Single Center Experiences

    Nowroozi

    2015-09-01

    Full Text Available Background Testicular cancer accounts for about 1 - 1.5% of all malignancies in men. Radical orchiectomy is curative in 75% of patients with stage I disease, but advance stage with retroperitoneal lymph node involvement needs chemotherapy. All patients who have residual masses ≥ 1 cm after chemotherapy should undergo postchemotherapy retroperitoneal lymph node dissection (PC-RPLND. Objectives Treatment of advanced nonseminomatous testicular cancer is usually a combination of chemotherapy and surgery. We described our experience about postchemotherapy retroperitoneal lymph node dissection (PC-RPLND in our center. Patients and Methods In a retrospective cross-sectional study between 2006 and 2011, patients with a history of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND in Imam Khomeini hospital were evaluated. All patients had normal postchemotherapy serum tumor markers and primary nonseminomatous cancer. We reviewed retrospectively clinical, pathological, and surgical parameters associated with PC-RPLND in our center. Results Twenty-one patients underwent bilateral PC-RPLND. Mean age was 26.3 years (ranged 16 - 47. Mean size of retroperitoneal mass after chemotherapy was 7.6 cm. Mean operative time was 198 minutes (120 - 246 minutes. Mean follow-up time was 38.6 months. Pathologic review showed presence of fibrosis/necrosis, viable germ cell tumor and teratoma in 8 (38.1%, 10 (47.6% and 3 (14.28% patients, respectively. One patient in postoperative period of surgery and three patients in two first years after surgery were expired. Of 17 alive patients, only two (11.8% had not retrograde ejaculation. Conclusions PC-RPLND is one the major operations in the field of urology, which is associated with significant adjunctive surgeries. In appropriate cases, PC-RPLND was associated with good cancer specific survival in tertiary oncology center.

  9. Current-direction dependence of the transport properties in single-crystalline face-centered-cubic cobalt films

    Xiao, X.; Liang, J. H.; Chen, B. L.; Li, J. X.; Ding, Z.; Wu, Y. Z., E-mail: wuyizheng@fudan.edu.cn [Department of Physics, State Key Laboratory of Surface Physics and Collaborative Innovation Center of Advanced Microstructures, Fudan University, Shanghai 200433 (China); Ma, D. H. [Department of Energy Engineering, Pennsylvania State University, University Park, Pennsylvania 16802 (United States)

    2015-07-28

    Face-centered-cubic cobalt films are epitaxially grown on insulating LaAlO{sub 3}(001) substrates by molecular beam epitaxy. Transport measurements are conducted in different current directions relative to the crystal axes. We find that the temperature dependent anisotropic magnetoresistance ratio strongly depends on the current direction. However, the anomalous Hall effect shows isotropic behavior independent of the current direction. Our results demonstrate the interplay between the current direction and the crystalline lattice in single-crystalline ferromagnetic films. A phenomenological analysis is presented to interpret the experimental data.

  10. 5-year Mortality in Hemodialysis Patients: A Single Center Study in Tripoli

    Buargub Mahdia

    2008-01-01

    Full Text Available To investigate the 5-year mortality of patients undergoing maintenance hemo-dialysis (HD at Al-Shat center Tripoli, we reviewed during June 2007 the records of all the HD patients initiated on HD from Jun 2000 and Jan 2002.There were 124 patients in the study, 77 males (63.6% and 47 (36.4% females, with a mean age of 49 ± 14 years. Diabetic nephropathy (DN was the underlying kidney disease in 34 (27.4% patients. After 5 years; 3 patients were transferred to other centers, 18 (14.9% patients underwent kidney transplan-tation. Out of the 103 patients who continued on hemodialysis, 53 (51.4% expired during the 5-year follow-up. Mortality was associated with older age (p< 0.001 and odd ratio (OR of 4.2 for age > 50 years and DN (p< 0.002 and OR of 3.9. Mortality rate in diabetics was 74.1% and significantly associated with male sex (p< 0.0067 and OR of 2.4, older age (p< 0.004, presence of hypertension (p< 0.003 and OR of 3.9, type 1 diabetes (OR 1.6, and elevated mean body weight (p< 0.046. Mortality was also relatively higher in black patients (OR of 2.0 and smokers (OR of 1.39. In conclusion, the overall 5- year mortality for dialysis patients was elevated and higher in the diabetics.

  11. Urinary tract infections following renal transplantation: A single-center experience

    Samia Barbouch

    2012-01-01

    Full Text Available Urinary tract infection (UTI is the most frequent infectious complication among renal transplant recipients and a frequent cause of bacteremia, sepsis and acute graft failure. To evaluate the incidence, risk factors, type of pathogens and long-term effect of UTIs on graft and patient survivals in our center, we performed a retrospective cohort study reviewing the medical records of patients who received a renal transplant at our center from June 1986 to December 2009, excluding patients who lost their grafts in the first month due to arterial or veins thrombosis and acute antibody-mediated rejection. We studied 393 kidney-transplanted recipients; at least one UTI occurred in 221 (53.69% patients during the follow-up period. The most frequent pathogens isolated in urine culture were Escherichia coli (n = 39, 18.4% and Klebsiella pneumonia (n = 31, 14.6%. When patients with UTIs were compared with those without UTIs, female gender and use of mycophenolate mofetil or azathioprine seemed to be risk factors for UTIs on univariate analysis. However, female gender was the only independent risk factor on multivariate analysis RR = 1.964 (1.202-3.207, P = 0.007. This study confirmed that UTIs remain a major problem in renal transplant recipients, and female gender was the only independent risk factor.

  12. NV Center Electron Paramagnetic Resonance of a Single Nanodiamond Attached to an Individual Biomolecule

    Teeling-Smith, Richelle M.; Jung, Young Woo; Scozzaro, Nicolas; Cardellino, Jeremy; Rampersaud, Isaac; North, Justin A.; Šimon, Marek; Bhallamudi, Vidya P.; Rampersaud, Arfaan; Johnston-Halperin, Ezekiel; Poirier, Michael G.; Hammel, P. Chris

    2015-01-01

    A key limitation of electron paramagnetic resonance (EPR), an established and powerful tool for studying atomic-scale biomolecular structure and dynamics is its poor sensitivity, samples containing in excess of 10^12 labeled biomolecules are required in typical experiments. In contrast, single molecule measurements provide improved insights into heterogeneous behaviors that can be masked by ensemble measurements and are often essential for illuminating the molecular mechanisms behind the func...

  13. Self-reported medicine use among 11- to 15-year-old girls and boys in Denmark 1988-1998

    Holstein, Bjørn E; Holme Hansen, Ebba; Due, Pernille;

    2003-01-01

    To describe the self-reported medicine use for common health complaints among 11-15-year-olds in Denmark during a ten year period, 1988-1998. The paper focuses on medicine for headache, stomach ache, cough, cold, nervousness, and difficulties in getting to sleep.......To describe the self-reported medicine use for common health complaints among 11-15-year-olds in Denmark during a ten year period, 1988-1998. The paper focuses on medicine for headache, stomach ache, cough, cold, nervousness, and difficulties in getting to sleep....

  14. Connection of educational level of parents and habits of visiting the dentist at 15 year old children

    Denkova, Natasa; Naskova, Sanja; Majstorceva, Meri; Veninov, Filip

    2014-01-01

    The main purpose if this study is to determine the correlation between education level of parents and habits of visiting the dentist at 15 year old children from rural and urban areas.Materials and Methods: The study included selected group of students at 15 year old and their parents ( 120 from urban and 120 from rural areas) and their parents who filled guestionnaires for the educational level of parents ( elementary, middle, high, Phd) and habits of visiting the dentist. Using the X2 test ...

  15. Pulmonary Functions in Normal School Children in the Age Group of 6-15 Years in North India

    Dhooria, Gurdeep S.; Puneet A. Pooni; Daljit Singh; Sandeep Budhiraja

    2010-01-01

    Objective:Lung function tests have become an integral part of assessment of pulmonary disease. As few studies on pulmonary function tests have been carried out in young children in India, the study was carried out in normal urban and rural school children in Ludhiana district of North India to determine pulmonary functions in the age group 6-15 years and to find its correlation with regards to age, sex, height and weight. Methods:The study group included 600 normal children between 6-15 years...

  16. PHYSICAL ACTIVITY AND LEISURE TIME AMONG 13-15-YEAR-OLD TEENAGERS LIVING IN BIAŁA PODLASKA

    Grad Rafał

    2013-01-01

    The aim of the research was to get information about physical activity and forms of spending leisure time by teenagers between 13 and 15 years old, who live in Biała Podlaska. The research included 229 pupils from three Grammar Schools (115 girls and 114 boys). The range of respondents’ age is from 13 to 15 years old. The research tool was anonymous questionnaire consisting of questions concerning healthy lifestyle, physical activity and forms of spending leisure time. In total, the questionn...

  17. Ankle sprain injuries in soccer players aged 7-15 years during a one-year season

    NIKOLAOS KOFOTOLIS

    2014-01-01

    Although ankle sprains are common in soccer, the role of various risk factors in soccer players aged 7-15 is unclear. The purpose of this study was to examine whether incidence of ankle sprain injuries, associated time loss of participation, and injury risk factors are associated with chronological age in soccer players aged 7-15 years. A sample of 677 male soccer players was divided in three age groups: between 7 and 9 years (U9), between 9 and 12 years (U12) and between 12 and 15 years (U15...

  18. Convergence of CI single center calculations of positron-atom interactions

    Mitroy, J

    2006-01-01

    The Configuration Interaction (CI) method using orbitals centered on the nucleus has recently been applied to calculate the interactions of positrons interacting with atoms. Computational investigations of the convergence properties of binding energy, phase shift and annihilation rate with respect to the maximum angular momentum of the orbital basis for the e^+Cu and PsH bound states, and the e^+-H scattering system were completed. The annihilation rates converge very slowly with angular momentum, and moreover the convergence with radial basis dimension appears to be slower for high angular momentum. A number of methods of completing the partial wave sum are compared, an approach based on a Delta X_J = a/(J + 1/2)^n + b/(J + 1/2)^(n+1) form (with n = 4 for phase shift (or energy) and n = 2 for the annihilation rate) seems to be preferred on considerations of utility and underlying physical justification.

  19. Convergence of configuration-interaction single-center calculations of positron-atom interactions

    The configuration interaction (CI) method using orbitals centered on the nucleus has recently been applied to calculate the interactions of positrons interacting with atoms. Computational investigations of the convergence properties of binding energy, phase shift, and annihilation rate with respect to the maximum angular momentum of the orbital basis for the e+Cu and PsH bound states, and the e+-H scattering system were completed. The annihilation rates converge very slowly with angular momentum, and moreover the convergence with radial basis dimension appears to be slower for high angular momentum. A number of methods of completing the partial wave sum are compared; an approach based on a ΔXJ=a(J+(1/2))-n+b(J+(1/2))-(n+1) form [with n=4 for phase shift (or energy) and n=2 for the annihilation rate] seems to be preferred on considerations of utility and underlying physical justification

  20. Metastases of esophageal carcinoma to skeletal muscle:Single center experience

    Jan Cincibuch; Miroslav Myslive(c)ek; Bohuslav Melichar; (C)estmír Neoral; Iva Metelková; Michaela Zezulová; Hana Procházková-(S)tudentová

    2012-01-01

    Metastases of esophageal carcinoma to the skeletal muscle are rare,but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography (PET/CT).A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between 2006 and 2010 was retrospectively evaluated for the presence of skeletal muscle metastases.Four patients had skeletal muscle metastases of esophageal carcinoma,including two patients with squamous cell carcinoma.In another patient with squamous cell carcinoma of the esophagus and synchronous skeletal muscle metastases,muscle metastases were subsequently shown to be related to second primary pancreatic adenocarcinoma.In all cases,skeletal muscle metastases were the first manifestation of systemic disease.In three patients palliation was obtained with the combination of external beam radiation therapy,systemic chemotherapy or surgical resection.Skeletal muscle metastases are a rare complication of esophageal carcinoma.

  1. The prevalence of Iron Deficiency and Its Anemia in 1-5 Years Old Children and Their Mothers in Birjand City

    Azita Fesharakinia

    2014-03-01

    Full Text Available Background &Objective: Micronutrient deficiencies are the most common nutritional disorders in the world in which iron deficiency is the most important one. This study was done for investigating the prevalence of iron deficiency and its anemia in children and their mothers in Birjand city in 2011.Materials & Methods: 143 children of 1-5 years old who referred to the health care centers of Birjand city were chosen by multistage cluster random sampling method and both the children and mothers were studied. After filling the questionnaire about demographic characteristics of children and mothers, the hemoglobin and ferritin of both children and their mothers were measured.Results: 12.6 % of the children and 16.1% of the mothers had iron deficiency, 16.8 % of children and 15.4 % of mothers had iron deficiency anemia. Iron deficiency and iron deficiency anemia in both children and mothers was significantly higher especially among working mothers. Both children’s iron deficiency and iron deficiency anemia had a significant and direct relation with mother’s iron deficiency and iron deficiency anemia.Conclusion: It is recommended to elevate the awareness of mothers, especially the working ones about the danger of iron deficiency and its anemia in their children and themselves, educate them about the correct nutritional habits for their family and themselves, screen the children of 1-5 years old for iron deficiency and its anemia and also investigate mothers’ children with iron deficiency and iron deficiency anemia.

  2. Blood blister-like aneurysms: Single center experience and systematic literature review

    Gonzalez, Ana Marcos; Narata, Ana Paula; Yilmaz, Hasan [Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospital of Geneva (Switzerland); Bijlenga, Philippe; Radovanovic, Ivan; Schaller, Karl [Service of Neurosurgery, University Hospital of Geneva (Switzerland); Lovblad, Karl-Olof [Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospital of Geneva (Switzerland); Pereira, Vitor Mendes, E-mail: vitormpbr@hotmail.com [Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospital of Geneva (Switzerland)

    2014-01-15

    Blood blister-like aneurysms (BBAs) are a controversial entity. They arise from non-branching sites on the supraclinoid internal carotid artery (ICA) and are suspected to originate from a dissection. Our aim is to describe the BBA cases seen in our center and to present a systematic review of the literature on BBAs. We analyzed the eleven cases of BBA admitted to our center from 2003 to 2012. We assessed the medical history, treatment modality (endovascular and/or surgery), complications and clinical outcome. The cohort included 8 women and 4 men with a mean age of 53.16 years. Treatment of the BBA consisted of stenting and coiling in 5 patients, stenting only in 4 patients, coiling and clipping in 1 patient, clipping only in 1 patient, and conservative treatment in 1 patient. A good outcome was found in 10 patients, as defined by a modified Rankin Scale (mRS) less than or equal to two at three months. A systematic review of the literature was performed, and 314 reported patients were found: 221 patients were treated with a primarily surgical approach, and 87 patients were treated with a primarily endovascular approach. A rescue or second treatment was required in 46 patients (21%). The overall estimated treatment morbidity rate was 17%, and the mortality rate was 15%. BBAs exhibit more aggressive behavior compared to saccular aneurysms, and more intra-operative complications occur with BBAs, independent of the treatment type offered. They are also significantly more likely to relapse and rebleed after treatment. Endovascular treatment offers a lower morbidity–mortality compared with surgical approaches. Multilayer flow-diverting stents appear to be a promising strategy.

  3. Radiotherapy for calcaneodynia. Results of a single center prospective randomized dose optimization trial

    Ott, O.J.; Jeremias, C.; Gaipl, U.S.; Frey, B.; Schmidt, M.; Fietkau, R. [University Hospital Erlangen (Germany). Dept. of Radiation Oncology

    2013-04-15

    The aim of this work was to compare the efficacy of two different dose fractionation schedules for radiotherapy of patients with calcaneodynia. Between February 2006 and April 2010, 457 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received radiotherapy using the orthovoltage technique. One radiotherapy series consisted of 6 single fractions/3 weeks. In case of insufficient remission of pain after 6 weeks a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. Endpoint was pain reduction. Pain was measured before, immediately after, and 6 weeks after radiotherapy using a visual analogue scale (VAS) and a comprehensive pain score (CPS). The overall response rate for all patients was 87 % directly after and 88 % 6 weeks after radiotherapy. The mean VAS values before, immediately after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 65.5 {+-} 22.1 and 64.0 {+-} 20.5 (p = 0.188), 34.8 {+-} 24.7 and 39.0 {+-} 26.3 (p = 0.122), and 25.1 {+-} 26.8 and 28.9 {+-} 26.8 (p = 0.156), respectively. The mean CPS before, immediately after, and 6 weeks after treatment was 10.1 {+-} 2.7 and 10.0 {+-} 3.0 (p = 0.783), 5.6 {+-} 3.7 and 6.0 {+-} 3.9 (p = 0.336), 4.0 {+-} 4.1 and 4.3 {+-} 3.6 (p = 0.257), respectively. No statistically significant differences between the two single dose trial arms for early (p = 0.216) and delayed response (p = 0.080) were found. Radiotherapy is an effective treatment option for the management of calcaneodynia. For radiation protection reasons, the dose for a radiotherapy series is recommended not to exceed 3-6 Gy. (orig.)

  4. Single Center Retrospective Analysis of Conventional and Radial TIG Catheters for Transradial Diagnostic Coronary Angiography

    Marc Vorpahl

    2015-01-01

    Full Text Available Current guidelines favor the radial approach for coronary angiography. Therefore, specialty radial diagnostic catheters were designed to engage both coronary arteries with a single device. However, it is unclear if single catheters are superior to conventional catheters. A retrospective analysis was performed of consecutive right radial coronary angiographies to determine catheter use, fluoroscopy time, radiation dosage, and consumption of contrast. Procedures were performed with a single TIG catheter or conventional catheters (CONV. Procedures with coronary artery bypass grafts or ventricular angiographies were excluded. 273 transradial procedures were performed successfully. 95 procedures were performed with CONV and 178 procedures with a TIG. Crossover to additional catheters was higher in TIG (15.2% compared to CONV (5.3%, p=0.02. Fluoroscopy time was comparable between CONV and TIG, without crossover (2.2±1.2 min versus 2.3±1.2 min; n.s., however, greater in the case of crossover for CONV (5.8±0.7 and TIG (7.6±3.0; p=0.0001. Radiation dosage was similar in CONV and the TIG, without crossover (1419±1075, cGy∗cm2 versus 1690±1138; n.s., however, greater for CONV (2374±620 and TIG (3733±2281, p=0.05 with crossover. Overall, the amount of contrast was greater in TIG (56±13 mL versus CONV (48±3 mL; p=0.0003. CONV femoral catheters may be the primary choice for radial approach.

  5. Linear accelerator-based stereotactic radiosurgery in recurrent glioblastoma: A single center experience

    Sirin Sait

    2011-01-01

    Full Text Available Background/Aim. Management of patients with recurrent glioblastoma (GB comprises a therapeutic challenge in neurooncology owing to the aggressive nature of the disease with poor local control despite a combined modality treatment. The majority of cases recur within the highdose radiotherapy field limiting the use of conventional techniques for re-irradiation due to potential toxicity. Stereotactic radiosurgery (SRS offers a viable noninvasive therapeutic option in palliative treatment of recurrent GB as a sophisticated modality with improved setup accuracy allowing the administration of high-dose, precise radiotherapy. The aim of the study was to, we report our experience with single-dose linear accelerator (LINAC based SRS in the management of patients with recurrent GB. Methods. Between 1998 and 2010 a total of 19 patients with recurrent GB were treated using single-dose LINAC-based SRS. The median age was 47 (23-65 years at primary diagnosis. Karnofsky Performance Score was ≥ 70 for all the patients. The median planning target volume (PTV was 13 (7-19 cc. The median marginal dose was 16 (10-19 Gy prescribed to the 80%-95% isodose line encompassing the planning target volume. The median follow-up time was 13 (2-59 months. Results. The median survival was 21 months and 9.3 months from the initial GB diagnosis and from SRS, respectively. The median progression-free survival from SRS was 5.7 months. All the patients tolerated radiosurgical treatment well without any Common Toxicity Criteria (CTC grade > 2 acute side effects. Conclusion. Single-dose LINAC-based SRS is a safe and well- tolerated palliative therapeutic option in the management of patients with recurrent GB.

  6. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP ENTITLED ''SINGLE SPIN ASYMMETRIES'' (VOLUME 75)

    Single-transverse spin asymmetries (SSA) in strong interactions have a long history, starting from the 1970s and 1980s when surprisingly large single-transverse spin asymmetries were observed in p+p → πX and pp → Λ + X, where really none were expected. They have again attracted much interest in recent years from both experimental and theoretical sides. In particular, first measurements by the STAR, PHENIX, and BRAHMS collaborations at RHIC have now become available which again reveal large single transverse spin asymmetries for hadron production in polarized proton proton scattering. This extends the SSA observations from the fixed target energy range to the collider regime. Meanwhile, experimental studies in Deep Inelastic Scattering by the HERMES collaboration at DESY, SMC at CERN, and CLAS at JLab also show a remarkably large SSA in semi-inclusive hadron production, γ*p → πX, when the proton is transversely polarized. On the theoretical side, there are several approaches to understanding SSA within Quantum Chromodynamics (QCD). For example, to explain the large SSAs for hadron production in hadron collisions, a mechanism that takes into account the contribution from quark-gluon-quark correlations (twist-3) in the nucleon was proposed. On the other hand, possible origins of SSA in DIS and hadronic scattering were also found in leading-twist transverse momentum dependent parton distributions. Current theoretical efforts aim at a better conceptual understanding of these two types of mechanisms, and of their connections. We were very happy at this timely date to bring together the theorists and experimentalists of this field to review and discuss the current theoretical status and the latest experimental results. The whole workshop contained 25 formal talks, both experiment (15) and theory (10), and a few informal talks and many fruitful discussions. The topics covered all the relevant SSA observables, including in Deep Inelastic Scattering, the Drell

  7. Purcell-enhanced single-photon emission from nitrogen-vacancy centers coupled to a tunable microcavity

    Kaupp, Hanno; Mader, Matthias; Schlederer, Benedikt; Benedikter, Julia; Haeusser, Philip; Chang, Huan-Cheng; Fedder, Helmut; Hänsch, Theodor W; Hunger, David

    2016-01-01

    Optical microcavities are a powerful tool to enhance spontaneous emission of individual quantum emitters. However, the broad emission spectra encountered in the solid state at room temperature limit the influence of a cavity, and call for ultra-small mode volume. We demonstrate Purcell-enhanced single photon emission from nitrogen-vacancy (NV) centers in nanodiamonds coupled to a tunable fiber-based microcavity with a mode volume down to $1.0\\,\\lambda^{3}$. We record cavity-enhanced fluorescence images and study several single emitters with one cavity. The Purcell effect is evidenced by enhanced fluorescence collection, as well as tunable fluorescence lifetime modification, and we infer an effective Purcell factor of up to 2.0. With numerical simulations, we furthermore show that a novel regime for light confinement can be achieved, where a Fabry-Perot mode is combined with additional mode confinement by the nanocrystal itself. In this regime, effective Purcell factors of up to 11 for NV centers and 63 for si...

  8. The Impact of a Surgical Protocol for Enhanced Recovery on Living Donor Right Hepatectomy: A Single-Center Cohort Study.

    Kim, Seong Hoon; Kim, Young Kyu; Lee, Seung Duk; Lee, Eung Chang; Park, Sang Jae

    2016-04-01

    The concept of surgery for enhanced recovery (SFER) program has never been an issue in the context of living donor right hepatectomy (LDRH), much less its effects. The purpose of this study was to evaluate outcomes after the establishment of an SFER protocol for LDRH in a single center.A single-center cohort study was performed in 500 consecutive living donors who underwent right hepatectomy from January 2005 to June 2014 by analyzing the outcomes before and after an established SFER protocol that evolved with continuous refinements in surgical technique and management over 300 LDRHs, being in place on September 2011. Donor characteristics, operative outcomes, and postoperative complications divided into 2 groups (group 1, stepwise adjustment; group 2, complete adherence to the protocol) were compared.Donor characteristics were comparable in the 2 groups. Overall complication rate was 10.0% with no mortality. In group 2, operative time, hospital stay, and overall complication rate decreased significantly, and the morbidity was 1% and confined in grade I complication without reoperation, perioperative blood transfusion, or readmission. All donors in this series recovered fully and returned to the previous functional lifestyle.An SFER protocol on LDRH can be established by the gradual implementation of various refinements of surgical technique, and the recent outcomes achieved after the establishment of an SFER protocol could provide a current guidance on LDRH toward the ultimate goal of zero morbidity. PMID:27057855

  9. Efficacy of liver transplantation for acute hepatic failure:a single-center experience

    Xian-Jie Shi; Hong-Bin Xu; Wen-Bin Ji; Yu-Rong Liang; Wei-Dong Duan; Lei He; Ming-Jun Wang; Zhi-Ming Zhao

    2011-01-01

    BACKGROUND: Acute hepatic failure (AHF) is a devastating clinical syndrome with a high mortality rate. The outcome of AHF varies with etiology, but liver transplantation (LT) can significantly improve the prognosis and survival rate of such patients. This study aimed to detect the role of LT and artificial liver support systems (ALSS) for AHF patients and to analyze the etiology and outcome of patients with this disease. METHODS: A retrospective analysis was made of 48 consecutive patients with AHF who fulfilled the Kings College Criteria for LT at our center. We analyzed and compared the etiology, outcome, prognosis, and survival rates of patients between the transplantation (LT) group and the non-transplantation (N-LT) group. RESULTS: AHF was due to viral hepatitis in 25 patients (52.1%; hepatitis B virus in 22), drug or toxic reactions in 14 (29.2%; acetaminophen in 6), Wilson disease in 4 (8.3%), unknown reasons in 3 (6.3%), and miscellaneous conditions in 2 (4.2%). In the LT group, 36 patients (7 underwent living donor LT, and 29 cadaveric LT) had an average model for end-stage liver disease score (MELD) of 35.7. Twenty-eight patients survived with good graft function after a follow-up of 27.3± 4.5 months. During the waiting time, 6 patients were treated with ALSS and 2 of them died during hospitalization. The 30-day, 12-month, and 18-month survival rates were 77.8%, 72.2%, and 66.7%, respectively. In the N-LT group, 12 patients had an average MELD score of 34.5. Four patients were treated with ALSS and all died during hospitalization. The 90-day and 1-year survival rates were only 16.7% and 8.3%, respectively. CONCLUSIONS: Hepatitis is the most prominent cause of AHF at our center. Most patients with AHF, who fulfill the Kings College Criteria for LT, did not survive longer without LT. ALSS did not improve the prognosis of AHF patients, but may extend the waiting time for a donor. Currently, LT is still the most effective way to improve the prognosis

  10. Donor safety in living donor liver transplantation: a single-center analysis of 300 cases.

    Jianyong Lei

    Full Text Available AIM: To evaluate the safety to donors of living-donor liver transplantation. METHODS: This study included 300 consecutive living liver tissue donors who underwent operations at our center from July 2002 to December 2012. We evaluated the safety of donors with regard to three aspects complications were recorded prospectively and stratified by grade according to Clavien's classification, and the data were compared in two stages (the first 5 years' experience (pre-January 2008 and the latter 5 years' experience (post-January 2008; laboratory tests such as liver function and blood biochemistry were performed; and the health-related quality of life was evaluated. RESULTS: There was no donor mortality at our center, and the overall morbidity rate was 25.3%. Most of the complications of living donors were either grade I or II. There were significantly fewer complications in the latter period of our study than in the initial period (19.9% vs 32.6%, P<0.001, and biliary complications were the most common complications, with an incidence of 9%. All of the liver dysfunction was temporary; however, the post-operative suppression of platelet count lasted for years. Although within the normal range, eight years after operation, 22 donors showed lower platelet levels (189 × 10(9/L compared with the pre-operative levels (267 × 10(9/L (P<0.05. A total of 98.4% of donors had returned to their previous levels of social activity and work, and 99.2% of donors would donate again if it was required and feasible. With the exception of two donors who experienced grade III complications (whose recipients died and a few cases of abdominal discomfort, fatigue, chronic pain and scar itching, none of the living donors were affected by physical problems. CONCLUSION: With careful donor selection and specialized patient care, low morbidity rates and satisfactory long-term recovery can be achieved after hepatectomy for living-donor liver transplantation.

  11. Early liver retransplantation versus late liver retransplantation:analysis of a single-center experience

    CHEN Gui-hua; ZHANG Jun-feng; ZHANG Tong; WANG Guo-ying; FU Bin-sheng; YANG Yang; CAI Chang-jie; LU Min-qiang; LI Hua; WANG Gen-shu; YI Shu-hong; XU Chi

    2008-01-01

    Background Orthotopic liver retransplantation (re-OLT) is the only effective therapy for irreversible failure of a liver graft. Early and late graft failure gives way to two different clinical conditions that should be discussed separately. This study was designed to compare early and late re-OLT for patients with poor graft function after primary transplantation at our center and sum up our clinical experience in re-OLT.Methods The clinical data of 31 re-OLTs at our center from January 2004 to February 2007 were analyzed retrospectively, consisting of the first group with 14 cases of early re-OLT and the second group with 17 cases of late re-OLT.Results Biliary tract complications were the main indications for early re-OLT (57.1%) and late re-OLT (52.9%). Other common indications were vascular complications in early re-OLT and recurrence of primary diseases in late re-OLT. No significant differences were found between the groups with regard to the volume of bleeding during operation, cold ischemia time, operative duration, and perioperative mortality; except for the model of end-stage liver disease (MELD) score. Outcome was fatal for 7 patients in early re-OLT and 9 patients in late re-OLT. Two deaths were due to multiple organ failure with 3 deaths due to severe sepsis-related disease in early re-OLT, and 4 deaths were due to severe sepsis-related disease with 3 deaths due to recurrence of hepatocellular carcinoma (HCC) in late re-OLT. One and 2-year actuarial survival rates after re-OLT were 55.2% and 36.9%, respectively, for patients in early re-OLT, and 65.1% and 52% respectively, for patients in late re-OLT. No significant differences were found regarding survival rates between the two groups.Conclusions Similar clinical results can be achieved in early and late re-OLT. Proper indications and optimal operation timing, adequate preoperative preparation, experienced surgical procedures, and effective perioperative anti-infection strategy contribute to the

  12. Radiotherapy for achillodynia. Results of a single-center prospective randomized dose-optimization trial

    Ott, O.J.; Jeremias, C.; Gaipl, U.S.; Frey, B.; Schmidt, M.; Fietkau, R. [University Hospital Erlangen (Germany). Dept. of Radiation Oncology

    2013-02-15

    Background and purpose: The aim of this study was to compare the efficacy of two different dose-fractionation schedules for radiotherapy of patients with achillodynia. Patients and methods: Between February 2006 and February 2010, 112 consecutive evaluable patients were recruited for this prospective randomized trial. All patients underwent radiotherapy with an orthovoltage technique. One radiotherapy course consisted of 6 single fractions over 3 weeks. In case of insufficient remission of pain after 6 weeks, a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. The endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after radiotherapy with a visual analogue scale (VAS) and a comprehensive pain score (CPS). Results: The overall response rate for all patients was 84% directly after and 88% 6 weeks after radiotherapy. The mean VAS values before, directly after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 55.7 {+-} 21.0 and 58.2 {+-} 23.5 (p = 0.526), 38.0 {+-} 23.2 and 30.4 {+-} 22.6 (p = 0.076), and 35.4 {+-} 25.9 and 30.9 {+-} 25.4 (p = 0.521), respectively. The mean CPS before, directly after, and 6 weeks after treatment was 8.2 {+-} 3.0 and 8.9 {+-} 3.3 (p = 0.239), 5.6 {+-} 3.1 and 5.4 {+-} 3.3 (p = 0.756), 4.4 {+-} 2.6 and 5.3 {+-} 3.8 (p = 0.577), respectively. No statistically significant differences were found between the two single-dose trial arms for early (p = 0.366) and delayed response (p = 0.287). Conclusion: Radiotherapy is an effective treatment option for the management of achillodynia. For radiation protection, the dose of a radiotherapy series is recommended not to exceed 3-6 Gy. (orig.)

  13. Benign painful elbow syndrome. First results of a single center prospective randomized radiotherapy dose optimization trial

    Ott, O.J.; Hertel, S.; Gaipl, U.S.; Frey, B.; Schmidt, M.; Fietkau, R. [University Hospital Erlangen (Germany). Dept. of Radiation Oncology

    2012-10-15

    Background and purpose: The goal of the present study was to evaluate the efficacy of two different dose-fractionation schedules for radiotherapy (RT) of patients with painful elbow syndrome. Patients and methods: Between February 2006 and February 2010, 199 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received RT in orthovoltage technique. One RT course consisted of 6 single fractions/3 weeks. In case of insufficient remission of pain after 6 weeks a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. Endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after RT by a visual analogue scale (VAS) and a comprehensive pain score (CPS). Results: The overall response rate for all patients was 80% direct after and 91% 6 weeks after RT. The mean VAS values before, after and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 59.6 {+-} 20.2 and 55.7 {+-} 18.0 (p = 0.463), 32.1 {+-} 24.5 and 34.4 {+-} 22.5 (p = 0.256), and 27.0 {+-} 27.7 and 23.5 {+-} 21.6 (p = 0.818). The mean CPS before, after, and 6 weeks after treatment was 8.7 {+-} 2.9 and 8.1 {+-} 3.1 (p = 0.207), 4.5 {+-} 3.2 and 5.0 {+-} 3.4 (p = 0.507), 3.9 {+-} 3.6 and 2.8 {+-} 2.8 (p = 0.186), respectively. No statistically significant differences between the two single dose trial arms for early (p = 0.103) and delayed response (p = 0.246) were found. Conclusion: RT is an effective treatment option for the management of benign painful elbow syndrome. For radiation protection reasons the dose for a RT series is recommended not to exceed 3.0 Gy. (orig.)

  14. Presentation and Management of Paroxysmal Nocturnal Hemoglobinuria: A Single-Center Experience.

    Dal, Mehmet Sinan; Karakuş, Abdullah; Ekmen, Mehmet Önder; Ayyildiz, Orhan

    2016-03-17

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder characterized by intravascular hemolysis. Real-world experience of PNH management is largely unreported. A retrospective analysis was undertaken based on medical records from six patients with PNH [two with aplastic anemia (AA)] treated at our center, Dicle University, Turkey. Diagnosis was based on granulocyte PNH clones, ranging from 93% to 66%. All patients had symptoms consistent with PNH. One patient was managed adequately with supportive measures only. Five were treated with the complement inhibitor eculizumab. Follow-up data (<1 year) were available in four cases (the fifth had received only three infusions by final follow-up). Hemoglobin level in these four patients increased from 4.1-7.2 g/dL to 8.3-13.0 g/dL. Lactate dehydrogenase, a marker for hemolysis, decreased profoundly in the two non-AA patients, with more minor improvements in the two AA patients. Weakness and fatigue improved in all eculizumab-treated patients. Four of the five treated patients became transfusion independent, including the patient given only three infusions. In the remaining case, a patient with AA, transfusion requirement decreased, and abdominal pain and dysphagia resolved. No adverse events occurred. PNH can be successfully managed in routine practice. PMID:27103981

  15. [De novo malignant tumors following liver transplantation. A single-center experience in Argentina].

    Antinucci, Florencia; Anders, Margarita; Orozco, Federico; Mella, José; Cobos, Manuel; McCormack, Lucas; Mastai, Ricardo

    2015-01-01

    The aim of the present study was to evaluate the incidence and clinical features of de novo tumors in patients undergoing liver transplantation in our center as well as to assess survival. We retrospectively analyzed 168 liver transplantations (159 patients) performed from May 2006 to May 2014. The incidence of de novo tumors was 7.5% (n = 12). The mean age at diagnosis was 63 ± 7 years. The most frequent neoplasms were non melanoma skin tumors and adenocarcinomas. Fifty percent of the tumors developed in the second and third year after transplantation. Type of immunosuppression did not influence tumoral type, although most patients receive tacrolimus in combination with mycofenolate and/or corticoids. The mean duration of follow-up after diagnosis of the tumor was 25 ± 29 months (range 0-76) and the mortality was 41%. The actuarial probability of survival at 1 and 5 years was 83 and 55%, respectively. De novo tumors are frequent after liver transplantation and their clinical course differs from that in the general population. Because their clinical course is more aggressive, regular follow up of these patients is essential for early diagnosis. PMID:25637895

  16. Frequency of kidney diseases and clinical indications of pediatric renal biopsy: A single center experience.

    Imtiaz, S; Nasir, K; Drohlia, M F; Salman, B; Ahmad, A

    2016-01-01

    Kidney biopsy occupies a fundamental position in the management of kidney diseases. There are very few renal pathology studies available in the literature from developing world. This study scrutinized the frequency and clinicopathological relationship of kidney biopsies done at the kidney center from 1997 to 2013 amongst pediatric patients. Kidney allograft biopsy were excluded. The specimen was examined under light microscopy and immunofluorescence while electron microscopy was not done. The study includes 423 patients, mean age was 10.48 ± 4.58 years, males 245 (57.9%) were more than females 178 (42.1%). Nephrotic syndrome 314 (74.2%) was the most common clinical presentation followed by acute nephritic syndrome 35 (8.3%) and acute renal failure 24 (5.7%). Primary glomerulonephritis (PGN) was the most common group of diseases, seen in 360 (85.1%) followed by secondary glomerulonephritis (SGN) in 27 (6.4%) and tubulointerstitial nephritis in 21 (5.0%). Among PGN, minimal change disease (MCD) was the most dominant disease, with 128 (30.3%) cases followed by focal segmental glomerulosclerosis FSGS in 109 (25.8%) and membranous glomerulonephropathy in 27 (6.4%). Lupus nephritis (LN) was the leading cause of glomerular disease in SGN followed by hemolytic uremic syndrome. In conclusion, MCD is the most common histological finding, especially in younger children and FSGS is second to it. SGN is rare, and the most common disease in this category is LN while tubulointerstitial and vascular diseases are infrequent. PMID:27194835

  17. Prevalence and Severity of Anemia in Pediatric Hemodialysis Patients; A Single Center Study

    Alaleh Ghasari

    2007-04-01

    Full Text Available Objective: To determine the prevalence and severity of anemia in children and adolescents on chronic hemodialysis and to identify independent predictor for anemia in children on hemodialysis. Material & Methods: A cross sectional study was performed between September 2005 and January 2006. The study population consisted of 25 patients aged 7−20 years on chronic hemodialysis from pediatric hemodialysis centers in Isfahan, Iran. Findings: A total of 22 (82% patients had hemoglobin level of 200 pg/ml in 16 patients (66% and >400 pg/ml in 9 patients (37.5%. There was a reverse correlation between PTH level>200 pg/ml and hemoglobin level (r=-0.505, P=0.046. Conclusion: The prevalence of anemia in children on hemodialysis in Isfahan appears to be higher than that reported in the other studies in spite of extensive use of rHuEPO and iron supplementation. We found this to be especially true for patients new on hemodialysis (less than 6 months, low albumin and severe hyperparathyroidism.

  18. Pathology of pediatric liver tumors, a single center experience from south of Iran

    Geramizadeh Bita

    2010-07-01

    Full Text Available Background: Pediatric hepatic malignancies are rare, accounting for 1-4% of all solid childhood tumors. The histopathology of childhood hepatic tumors guides the treatment and prognosis, and is the cornerstone for precise diagnosis. Until now, there has been no documented study on pediatric liver tumor cases from this center; in this report, we show our experience about the common types of childhood hepatic tumors during five years (2002-2007 and compare them with other studies. Materials and Methods: During five years (2002-2007, all the hepatic tumors of childhood (under 18 year-old from the pathology file of Namazi Hospital of Shiraz University of Medical Sciences are recorded. This includes both resected specimens and biopsies. All the slides were reviewed and the pathologic diagnosis was confirmed. Results: We detected 53 liver tumor cases in children (below 18 years of age. Among these tumors, 36 (67.9% were malignant. Male to female ratio was 1.5 to 1. Hepatoblastoma was the most common liver tumor in this age group accounting for 22 patients (41.5%. The second most common primary tumor was hepatocellular carcinoma (HCC, with five patients. Another malignant tumor was embryonal sarcoma. Benign tumors included adenoma, mesenchymal hamartoma, vascular tumors, focal nodular hyperplasia, and inflammatory pseudo tumor. There were also seven metastatic tumors during these five years. Conclusions: The spectrum of hepatic tumors in children is different from that found in the older age group (adults and also different in different populations.

  19. Acute lymphoblastic leukemia: A single center experience with Berlin, Frankfurt, and Munster-95 protocol

    Venkatraman Radhakrishnan

    2015-01-01

    Full Text Available Background: There is a paucity of data on the outcome following the treatment for acute lymphoblastic leukemia (ALL from developing countries. Materials and Methods: Two hundred and thirty-eight consecutive patients with ALL <30 years of age diagnosed between January 2005 and December 2011 were analyzed retrospectively. Patients were treated modified Berlin, Frankfurt, and Munster 95 protocol. Event-free survival (EFS was calculated using Kaplan-Meier survival analysis and variables were compared using log-rank test. Results: The EFS was 63.4% at a median follow-up was 32.7 months. On univariate analysis National Cancer Institute (NCI risk stratification, sex, white blood cell count, day 8 blast clearance, and income were significantly associated with EFS. However, on multivariate analysis only female sex (P = 0.01 and day 8 blast clearance (P = 0.006 were significantly associated with EFS. Seventy-four of 238 (31% patients had recurrent leukemia. The common sites of relapse were bone marrow in 55/74 (75% patients and central nervous system in 11/74 (20% patients. Conclusion: Compared to western data, there was an increased proportion of NCI high-risk patients and T-cell immunophenotype in our study. There has been an improvement in outcome of patients with ALL at our center over the last 2 decades. Female sex and clearance of blast in peripheral blood by day 8 of induction was associated with better EFS.

  20. A Polysomnography Study of Kleine-Levin Syndrome in a Single Center

    Yan-Wen Luo; Huan Yu; Lu-Hua Yuan; Guo-Xing Zhu

    2016-01-01

    Background:Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of hypersomnia.Polysomnographic (PSG) researches of KLS have been reported only in few publications in the past decades.This study aimed to investigate the characteristics of PSG of KLS.Methods:This study,which was conducted from March 2010 to July 2014,included seven patients diagnosed with KLS in the Sleep and Wake Disorder Center of Huashan Hospital,Fudan University (Shanghai,China).PSG and multiple sleep latency tests (MSLT) were performed during their episodes and the results were evaluated.Results:Five of the seven patients were males.The mean age at KLS onset was 15.6 ± 3.6 years.The number of episodes ranged from 2 to 7.The duration of episodes lasted from 4 to 11 days.The sleep architecture and proportion were normal in most of the patients.The average value of mean sleep latency was 6.9 ± 4.1 min.No sleep-onset rapid eye movement (SOREM) was detected in three of the patients,whereas one patient experienced one period of SOREM,and such episodes occurred twice in other two patients.Conclusions:We found that sleep architecture and proportion were normal in most KLS patients.However,the results of PSG and MSLT had no specificity for KLS patients.

  1. A single center study of the effects of trained fathers' participation in constant breastfeeding.

    Khadijeh Raeisi

    2014-09-01

    Full Text Available Constant breastfeeding that depends on the family support. Fathers' involvement is as an important factor of successful breastfeeding. The aim of this study was to evaluate the influence of fathers' participation in constant breastfeeding in Vali-E-Asr Hospital, Tehran, Iran. This interventional study was piloted on spouses of pregnant women participating in pregnancy courses. The case group consisted of fathers attending training courses of breastfeeding during pregnancy (Group A, and the control group was made up of fathers who did not take part in training courses (Group B. The courses were held three times from the 30th week of gestation to the end of pregnancy in a family health research center. Fathers attended three training sessions where they were trained by brochures. After delivery newborns were weighted and examined for jaundice (3-5 days, 30 days, three and six months after birth. According to mothers' views, spouses' participation, encouragement and support in group A, was 11 times more than group B. It means that 47 (94% of spouses in the group A participated in mothers' constant breastfeeding, but fathers' participation in group B was 60% (30 spouses. This study showed that breastfeeding was more constant in the group that fathers participated in breastfeeding training course. One of the reasons for such a significant difference was spouses' participation, encouragement and support in the trained group. This study showed that fathers' involvement in training programs may influence constancy of breastfeeding.

  2. The Characteristics and Surgical Approach in Post-Traumatic Diaphragmatic Hernia: A Single Center Experience

    Mushtaq Ahmed Chowdhary

    2013-07-01

    Full Text Available Objectives: The aim of this study was to evaluate the surgical approach in post traumatic diaphragmatic hernia Methods: This prospective cross-sectional study was conducted in the Department of cardiovascular and thoracic surgery, Sher-i- Kashmir Institute of Medical Sciences (SKIMS, Kashmir, India. We included all patients with post traumatic diaphragmatic hernia undergoing operation in our center from May 2009 to November2011. A detailed history was taken for each patient along with comprehensive general, physical, systemic and local examination of all cases. Operative findings included associated intra-abdominal injuries, and herniated intra-abdominal organs. Post-operative complications, mortality and survival were recorded and reported. Results: The mean age of the patients was 32±1 years and there were 16 (76.1% men and 5 (23.8% women among the patients. Thoracotomy was performed in 14 patients (66.7%, laparotomy in 6 patients (28.6% and combined procedure was used in 1 patient (4.7%. The reduction of hernia contents with repair of diaphragmatic rent was done in 11 (52.2% of the patients and splenectomy with repair of rent in 6 (28.6%. Traumatic diaphragmatic hernia had 81.8% survival rate, no pre-operative mortality and 14.3% post operative mortality rate.Conclusion: Thoracotomy is the most common approach in post traumatic diaphragmatic hernia. Laparotomy is preferred in patients having acute trauma with associated intra-abdominal injuries.

  3. Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience

    Hermansen, Kjeld; Bohl, Mette; Schioldan, Anne Grethe

    2015-01-01

    Limiting excessive postprandial glucose excursions is an important component of good overall glycemic control in diabetes mellitus. Pharmacokinetic studies have shown that insulin aspart, which is structurally identical to regular human insulin except for the replacement of a single proline amino acid with an aspartic acid residue, has a more physiologic time–action profile (i.e., reaches a higher peak and reaches that peak sooner) than regular human insulin. As expected with this improved ph...

  4. Hydrogen effects on nanovoid nucleation in face-centered cubic single-crystals

    Monte Carlo (MC) and molecular dynamics (MD) simulations using embedded atom method (EAM) potentials were performed to study nanovoid nucleation in single-crystal nickel specimens in a hydrogen-precharged and a hydrogen dynamically-charged condition. In the hydrogen-precharged condition, MC simulations were performed to introduce hydrogen atoms in an unstressed specimen. MD simulations were then performed to study nanovoid nucleation and the associated plasticity. In the dynamically-charged condition, a novel coupled MD-MC process was used to introduce hydrogen into the specimen while the specimen was being strained until nanovoid nucleation occurred. The simulation results revealed that hydrogen only reduced the nanovoid nucleation stress in the precharged case slightly but caused a lower strain-hardening and a significant reduction in the nanovoid nucleation stress in the dynamically-charged case

  5. Safety of Early Carotid Artery Stenting after Systemic Thrombolysis: A Single Center Experience

    Fabrizio Sallustio

    2012-01-01

    Full Text Available Background. Patients with acute ischemic stroke due to internal carotid artery (ICA disease are at high risk of early stroke recurrence. A combination of IV thrombolysis and early carotid artery stenting (CAS may result in more effective secondary stroke prevention. Objective. We tested safety and durability of early CAS following IV thrombolysis in stroke patients with residual stenosis in the symptomatic ICA. Methods. Of consecutive patients treated with IV rtPA, those with residual ICA stenosis ≥70% or 24 hours. The protocol included pre-rtPA MRI and MR angiography, and post-rtPA carotid ultrasound and CT angiography. Stroke severity was assessed by the NIH Stroke Scale (NIHSS. Three- and twelve-month stent patency was assessed by ultrasound. Twelve-month functional outcome was assessed by the modified Rankin Scale (mRS. Results. Of 145 consecutive IV rtPA-treated patients, 6 (4% underwent early CAS. Median age was 76 (range 67–78 years, median NIHSS at stroke onset was 12 (range 9–16 and 7 (range 7-8 before CAS. Median onset-to-CAS time was 48 (range 30–94 hours. A single self-expandable stent was implanted to cover the entire lesion in all patients. The procedure was uneventful in all patients. After 12 months, all patients had stent patency, and the functional outcome was favourable (mRS ≤ 2 in all but 1 patient experiencing a recurrent stroke for new-onset atrial fibrillation. Conclusion. This small case series of a single centre suggests that early CAS may be considered a safe alternative to CEA after IV rtPA administration in selected patients at high risk of stroke recurrence.

  6. Financial Literacy of 15-Year-Olds: Results from PISA 2012. Data Point. NCES 2014-102

    Gonzales, Patrick; Kelly, Dana

    2014-01-01

    This Data Point uses data from the 2012 administration of the Program for International Student Assessment (PISA) financial literacy assessment. PISA is an international assessment that measures 15-year-old students' reading, mathematics, and science literacy and, in 2012, general problem solving and financial literacy. PISA is coordinated by…

  7. Proficiency Assessment of Male Volleyball Teams of the 13-15-Year Age Group at Estonian Championships

    Stamm, Meelis; Stamm, Raini; Koskel, Sade

    2008-01-01

    Study aim: Assessment of feasibility of using own computer software "Game" at competitions. Material and methods: The data were collected during Estonian championships in 2006 for male volleyball teams of the 13-15-years age group (n = 8). In all games, the performance of both teams was recorded in parallel with two computers. A total of 19 games…

  8. Effects of schooling on reading performance, reading engagement, and reading activities of 15-year-olds in England

    Luyten, Hans; Peschar, Jules; Coe, Robert

    2008-01-01

    This article reports the findings of an analysis into the effect of one year's schooling for 15-year-olds in England on reading performance, reading engagement, and reading activities. The analyses were done on PISA 2000 data by applying a regression discontinuity approach within a multilevel framew

  9. The Relationship between Psychological Health and Attitude toward Christianity among Pupils Aged 11 to 15 Years in England

    Francis, Leslie J.; Burton, Linda

    2007-01-01

    Advocates of the secularization thesis describe radical decline in the significance of the Christian tradition among young people in England. In this context, a sample of 5,808 pupils age 11 to 15 years provided data about their religious identity and practice and completed the short-form Revised Junior Eysenck Personality Questionnaire (as a…

  10. Is Antibiotic Usage Necessary after Donor Nephrectomy? A Single Center Experience

    Zomorrodi Afshar

    2008-01-01

    Full Text Available Proper management of living kidney donors is a very important aspect of all renal transplants. To date, approximately 60,000 living donor nephrectomies have been performed worldwide and about 20 deaths directly related to the operation have been reported. The most common cause of death has been pulmonary embolism. Wound infection following surgery is the third most common nosocomial infection, and is dependent on the surgeon and his/her team, the operating room, number and virulence of contaminated bacteria, patient characteristics (immunity and defense, as well as time and duration of administration of antibiotics. Approach to the prophylaxis of wound infection in kidney donors varies in different transplant centers. This study was conducted at the Emam Hospital, Tabriz, Iran in order to delineate the protocol regarding antibiotic usage after donor nephrectomy. One hundred kidney donors were enrolled in the study. They were classified randomly in two groups: Group-1, comprising 50 donors, who received antibiotics immediately following surgery and for at least seven days thereafter. Group-2, comprised of 50 donors, in whom one gram of cephazoline was injected intravenously before anesthesia and continued for 24 hours after surgery. The patients were followed-up for one month with particular emphasis on occurrence of wound infection. One patient in Group-1, and two in Group-2 had wound infection; the difference was not statistically significant (p = > 0.5. Our study suggests that antibiotic prophylaxis started before incision and continued for 24 hours after donor nephrectomy is safe and effective in preventing wound infection.

  11. Laparoscopic splenectomy: a single center experience. Unusual cases and expanded inclusion criteria for laparoscopic approach.

    Marte, Gianpaolo; Scuderi, Vincenzo; Rocca, Aldo; Surfaro, Giuseppe; Migliaccio, Carla; Ceriello, Antonio

    2013-06-01

    Laparoscopic splenectomy (LS) is nowadays considered as the gold standard for most hematological diseases where splenectomy is necessary, but many questions still remain. The aim of this study was to analyze our 5-years experiences consisting of 48 consecutive LS cases in order to assess the optimal approach and the feasibility of the procedure also in malignant diseases and unusual cases such as a primary spleen lymphoma, a big splenic artery aneurism, or a spleen infarct due to a huge pancreatic pseudo-cyst. Forty-eight consecutive patients underwent LS from January 2006 to January 2011 with at least 1-year follow-up. Clinical data and immediate outcome were retrospectively recorded; age, diagnosis, operation time, perioperative transfusion requirement, conversion rate, accessory incision, hospital stay, and complications were analyzed. We had 14 cases of malignant splenic disease, the most frequent malignant diagnosis was non-Hodgkin's lymphoma (12/14, 85.7 %). Splenomegaly (interpole diameter (ID) >20 cm) was observed in 12 cases (25 %) and massive splenomegaly (ID >25 cm) in 3 cases (6.25 %). Conversion to laparotomy occurred in two patients (4.16 %), both associated to uncontrollable bleeding in patients with splenomegaly. Mean operative time was 138 ± 22 min. Mean hospital stay was 4.5 days. Postoperative morbidity rate was 8.8 % for the benign group and 35.7 % in the malignant group. Mortality occurred in 1/48 patients (2.08 %), as a result of overwhelming post-splenectomy infection (OPSI). LS can be performed safely for malignant splenic disease and splenomegaly without any statistically significant increase of morbidity and mortality rate. Conversion rate is increased for massive splenomegaly. LS should be considered as the preferential approach even in patients with malignant disease, splenomegaly, or unusual cases. Massive splenomegaly should be considered as relative contraindication to LS even at experienced centers. PMID:23355349

  12. Analysis of periinterventional complications of intracranial angioplasty and stenting: A single center experience

    Highlights: • Periinterventional complications in 7.5% of patients with intracranial artery stenting. • 2.5% of periinterventional complications were perforator strokes. • 3.8% of patients developed a hemorrhagic stroke due to reperfusion injury. • Complications could be reduced by individualized measures to prevent perforator stroke or reperfusion injury. - Abstract: Background and purpose: Treatment of symptomatic intracranial atherosclerotic disease by angioplasty and stenting (PTAS) is limited by a high rate of periinterventional strokes. We performed a detailed analysis of these strokes at our center in order to identify strategies to reduce the risk of periinterventional complications. Methods: Case records and imaging data of 80 patients with a symptomatic 70–99% stenosis of a major intracranial artery treated with PTAS between July 2007 and December 2013 were reviewed. All patients had a sufficient response to aspirin and clopidogrel. Periinterventional strokes were categorized as either ischemic (perforator territory, distal embolic or delayed stent thrombosis) or hemorrhagic (intraparenchymal, subarachnoid). Results: Periinterventional complications occurred in 6/80 (7.5%) patients, consisting of 2 ischemic strokes (2.5%, both perforator territory), 3 hemorrhagic strokes (3.8%, 2 intraparenchymal due to reperfusion injury, 1 subarachnoid due to vessel rupture) and one death (1.3%) unrelated to stroke. All strokes occurred within 24 h after PTAS. Conclusion: Our retrospective data analysis suggests that the risk of periinterventional stroke after PTAS of symptomatic intracranial atherosclerotic disease might be reduced by sufficient antiplatelet therapy and optimized management of patients with high risk for reperfusion injury or perforator strokes, including selection of a stenting device adapted to individual vessel morphology

  13. Conversion from temporary to tunneled catheters by nephrologists: report of a single-center experience

    Silva, Bruno C; Rodrigues, Camila E; Abdulkader, Regina CRM; Elias, Rosilene M

    2016-01-01

    Background Nephrologists have increasingly participated in the conversion from temporary catheters (TC) to tunneled-cuffed catheters (TCCs) for hemodialysis. Objective To prospectively analyze the outcomes associated with TCC placement by nephrologists with expertise in such procedure, in different time periods at the same center. The impact of vancomycin or cefazolin as prophylactic antibiotics on the infection outcomes was also tested. Patients and methods Hemodialysis patients who presented to such procedure were divided into two cohorts: A (from 2004 to 2008) and B (from 2013 to 2015). Time from TC to TCC conversion, prophylactic antibiotics, and reasons for TCC removal were evaluated. Results One hundred and thirty patients were included in cohort A and 228 in cohort B. Sex, age, and follow-up time were similar between cohorts. Median time from TC to TCC conversion was longer in cohort A than in cohort B (14 [3; 30] vs 4 [1; 8] days, respectively; P⩽0.0001). Infection leading to catheter removal occurred in 26.4% vs 18.9% of procedures in cohorts A and B, respectively, and infection rate was 0.93 vs 0.73 infections per 1,000 catheter-days, respectively (P=0.092). Infection within 30 days from the procedure occurred in 1.4% of overall cohort. No differences were observed when comparing vancomycin and cefazolin as prophylactic antibiotics on 90-day infection-free TCC survival in a Kaplan–Meier model (log-rank = 0.188). TCC removal for low blood flow occurred in 8.9% of procedures. Conclusion Conversion of TC to TCC by nephrologists had overall infection, catheter patency, and complications similar to data reported in the literature. Vancomycin was not superior to cefazolin as a prophylactic antibiotic. PMID:27114715

  14. A retrospective analysis of survival and prognostic factors of male breast cancer from a single center

    Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egyptian patients. We retrospectively analyzed OS in a cohort of 69 male patients with MBC who were surgically treated at the Mansoura Cancer Center, Egypt between 2000 and 2007. We registered demographic data, age, height, weight and body mass index, tumor size, histology, number of infiltrated axillary lymph nodes, hormone receptor (HR) status and metastatic presence, and TNM staging. Patients’ OS was the primary endpoint. Patients received treatment to the medical standards at the time of their diagnosis. In the 69 patients who met the inclusion criteria and had complete stored patient data, tumors ranged from T1c to T3. We could gather cancer-related survival data from only 56 patients. The collective 5-year survival in this cohort was 46.4%. Only five patients had distant metastasis at diagnosis, but they showed a null percent 5-year survival, whereas those with no lymph node infiltration showed a 100% 5-year survival. Lymph node status and tumor grading were the only prognostic factors that significantly affected OS. Lymph node status and tumor grade are the most important prognostic factors for overall survival of MBC in Egyptian male patients; whereas even remarkably low HR expression in MBC did not significantly affect OS. Further research is needed to understand the factors that affect this disease

  15. Clinical outcomes of liver transplantation for polycystic liver disease: a single center experience.

    Chandok, Natasha; Uhanova, Julia; Marotta, Paul

    2010-01-01

    Polycystic liver disease (PLD) is a celiopathy characterized by progressive growth of multiple hepatic cysts. In a minority of patients, severe symptomatic hepatomegaly necessitates liver transplantation (LT). The purpose of this study is to describe the postoperative and long-term outcomes of all patients transplanted for PLD at our center. All patients who underwent LT for PLD were identified through our database. Using patient charts, data were extracted on patient demographics and medical history, postoperative surgical and medical complications, length of hospitalization, prevalence of chronic kidney failure, and patient and graft survival. Subjects were contacted in April 2010 to verify their survival and confirm their need, if any, for hemodialysis and/or kidney transplantation. Descriptive statistics for patient and graft survival were performed. From 1993 to 2010, 14 subjects underwent LT and 1 subject underwent combined kidney and LT; all subjects were female and the mean age was 49.0 years. 10 (66.7%) subjects had polycystic kidney disease. Patients experienced a high rate of vascular complications, including hepatic artery thrombosis (HAT) or stenosis in 3 (20%) and 2 (13.3%) subjects, respectively. One subject had early graft loss due to HAT and underwent re-transplantation. The mean length of hospitalization was 18.8 days. After a mean of 66.8 months of follow-up (3-200), 13 (86.7%) subjects are alive with satisfactory graft function, and no patients had renal failure. In conclusion, patients who underwent LT for PLD had a high rate of postoperative vascular complications. However, long-term patient and graft survival, and kidney function, is excellent. PMID:20720268

  16. In-hospital mortality following acute myocardial infarction in Kosovo : A single center study

    Randomized trials have demonstrated that primary angioplasty is more effective than intravenous thrombolysis in reducing mortality and morbidity in patients with acute myocardial infarction (AMI). The aim of this study was to assess the in-hospital mortality of patients with AMI admitted to the only tertiary care center in Kosovo, where coronary percutaneous intervention procedures are unavailable. We also assessed the impact of age and gender on in-hospital mortality. Patients and Consecutive patients with the diagnosis of AMI, admitted in our institution between 1999 and 2007, were included in this retrospective study. Of 2848 patients (mean age 61±11.3 years, 73.4% males) admitted with AMI, 292 (10.25%) patients died during in-hospital stay. The overall in-hospital mortality was 12.3% for women and 9.5% for men (P<.05). Women were significantly older than men (64.2±11 years vs 59.7±11.8 years, P<.05). Mean length of stay was 12.0±94 for women and 10.7±7.6 for men. From 1999 to 2007 there was an increase in the age of patients with AMI but the mortality rate remained stable.Compared to developed countries, patients with AMI in Kosovo present at an earlier age but have a higher mortality rate. Women with AMI had a significantly higher in-hospital mortality rate than men. The lack of percutaneous coronary intervention procedures in AMI patients may have contributed to the high in-hospital mortality in our population (Author).

  17. Management of autoimmune hemolytic anemia in children and adolescents: A single center experience

    Nazan Sarper

    2011-09-01

    Full Text Available Objective: To present and discuss the treatment of autoimmune hemolytic anemia (AIHA. Materials and Methods: The medical records of all patients (n=19 diagnosed in a tertiary hematology center between 1999 and 2010 were retrospectively reviewed.Results: Median age at diagnosis of AIHA was 5 years (range: 4 months-17 years. In all, 13 patients had primary (idiopathic AIHA, whereas 2 had primary Evans Syndrome (ES, 2 had autoimmune lymphoproliferative syndrome (ALPS+ES, and 1 had Wiskott-Aldrich syndrome (WAS+AIHA. Among the 13 primary idiopathic AIHA patients, 9 recovered following a 4-8-week course of prednisolone treatment without relapses, whereas 3 patients required a longer course of prednisolone. One AIHA patient that was very resistant to prednisolone recovered after cyclosporine A was added to the treatment. All patients with primary idiopathic AIHA were in remission for a median of 3 years (range: 4 months-10 years at the time this manuscript was written. Among the patients with primary ES, 2 had relapses similar to the ALPS patients. Splenectomy was performed in 1 primary ES patient, who at the time this report was written was also in remission. One ALPS patient required the addition of mycophenolate mofetil due to prednisolone resistance. The WAS patient was treatment resistant and died due to septicemia.Conclusions: Primary AIHA in pediatric patients generally has an acute onset and good response to corticosteroids. Primary or secondary ES has a chronic or relapsing course, and treatment may require other immunosuppressive agents in addition to corticosteroids. Complications of splenectomy must not be underestimated in patients with underlying immunodeficiency. AIHA often causes considerable morbidity and mortality in WAS.

  18. Evaluation of Sensorimotor Nerve Damage in Patients with Maxillofacial Trauma; a Single Center Experience

    Behnaz Poorian

    2016-04-01

    Full Text Available Objective: To evaluate sensorimotor nerve damage in patients with maxillofacial trauma referring to Taleghani hospital, Tehran, Iran Methods: This cross-sectional study was conducted during a 2-year period from 2014 to 2012 in Taleghani hospital of Tehran. We included a total number of 495 patients with maxillofacial trauma referring to our center during the study period. The demographic information, type of fracture, location of fracture and nerve injuries were assessed and recorded in each patients. The frequency of sensorimotor injuries in these patients was recorded. Data are presented as frequencies and proportions as appropriate. Results: Overall we included 495 patients with maxillofacial trauma with mean age of 31.5±13.8 years. There were 430 (86.9% men and in 65 (13.1% women among the patients. The frequency of nerve injuries was 67.7% (336 patients. The mean age of the patients with nerve injuries was 33.4 ± 3.7 years. Marginal mandibular branch of facial nerve was the most common involved nerve being involved in 5 patients (1%. Regarding trigeminal nerve, the inferior alveolar branch (194 patients 39.1% was the most common involved branch followed by infraorbital branch (135 patients 27.2%. Mandibular fracture was the most common injured bone being reported in 376 patient (75.9% patients followed by zygomatic bone in 100 patient (20%. Conclusion: The most frequent fracture occurred in mandible followed by zygoma and the most injured nerve was inferior alveolar nerve followed by infraorbital branch of trigeminal nerve. In facial nerve the marginal branch was the most involved nerve. The frequency of nerve injury and the male to female ratio was higher in the current study compared to the literature.

  19. Analysis of periinterventional complications of intracranial angioplasty and stenting: A single center experience

    Silber, Toni; Ziemann, Ulf [Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen (Germany); Ernemann, Ulrike [Department of Diagnostic and Interventional Neuroradiology, University of Tübingen (Germany); Bischof, Felix, E-mail: felix.bischof@uni-tuebingen.de [Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen (Germany)

    2014-12-15

    Highlights: • Periinterventional complications in 7.5% of patients with intracranial artery stenting. • 2.5% of periinterventional complications were perforator strokes. • 3.8% of patients developed a hemorrhagic stroke due to reperfusion injury. • Complications could be reduced by individualized measures to prevent perforator stroke or reperfusion injury. - Abstract: Background and purpose: Treatment of symptomatic intracranial atherosclerotic disease by angioplasty and stenting (PTAS) is limited by a high rate of periinterventional strokes. We performed a detailed analysis of these strokes at our center in order to identify strategies to reduce the risk of periinterventional complications. Methods: Case records and imaging data of 80 patients with a symptomatic 70–99% stenosis of a major intracranial artery treated with PTAS between July 2007 and December 2013 were reviewed. All patients had a sufficient response to aspirin and clopidogrel. Periinterventional strokes were categorized as either ischemic (perforator territory, distal embolic or delayed stent thrombosis) or hemorrhagic (intraparenchymal, subarachnoid). Results: Periinterventional complications occurred in 6/80 (7.5%) patients, consisting of 2 ischemic strokes (2.5%, both perforator territory), 3 hemorrhagic strokes (3.8%, 2 intraparenchymal due to reperfusion injury, 1 subarachnoid due to vessel rupture) and one death (1.3%) unrelated to stroke. All strokes occurred within 24 h after PTAS. Conclusion: Our retrospective data analysis suggests that the risk of periinterventional stroke after PTAS of symptomatic intracranial atherosclerotic disease might be reduced by sufficient antiplatelet therapy and optimized management of patients with high risk for reperfusion injury or perforator strokes, including selection of a stenting device adapted to individual vessel morphology.

  20. Spontaneous Resolution of Vesicoureteral Reflux (VUR in Iranian Children, a Single Center Experience in 533 Cases

    B. Hatamian

    2009-06-01

    Full Text Available Background and ObjectivesExperience with vesicoureteral reflux (VUR differs in different centers and there are lots of controversies surrounding this issue. The aim of this study was to evaluate Spontaneous resolution and prognosis of the disease among Iranian children.MethodsIn this case series study, 1278 children with urinary tract infection and visited at pediatric nephrology clinic in Tehran, Iran during 1999-2007 were studied. Primary VUR was found in 533 Patients. Following the diagnosis, the patients received prophylactic antibiotic and were annually followed with radionucleo cystography (RNC. Patients underwent surgery in case the medical treatment failed (breakthrough infection or new renal scar formation.Results533 patients with VUR were studied. Patients’ mean age with VUR was 3.7±2.4 years (range: 2 days to 18 years old. During an average follow-up duration of 3.3+2.2 years, spontaneous resolution was observed in 40% of 279 patients who had follow-up RNCs. The mean interval between VUR diagnosis and spontaneous resolution was 1.5+ 1 years (range: 2 months to 6 years. The resolution rate was decreased with increment of reflux grade so that for grades I to V, VUR was resolved in 63%, 57%, 27%, 22% and 10% of the cases, respectively. Anti reflux surgery was performed in 27(10% of patients during follow-up.ConclusionBased on the excellent results obtained from clinical therapy using low dose antibiotics, it is recommended that VUR grades 1 to 4 be managed medically with low-dose oral antibiotic prophylaxis and close follow-ups.Keywords: Urinary Tract Infection; Vesico-Ureteral Reflux; Spontaneous Resolution; Child.

  1. Stent treatment for basilar artery dissection: A single-center experience of 21 patients.

    Li, Li; Li, Tianxiao; Xue, Jiangyu; Wang, Ziliang; Bai, Weixing; Zhu, Liangfu; Feng, Guang; Xu, Gangqin; Yang, Bowen

    2016-06-01

    Basilar artery dissection is a rare disease with high morbidity and mortality. No well-established management strategy exists for this lesion. Endovascular reconstructive therapy using stents (with or without coiling) may be the optimum strategy.We describe our center's experience for this treatment strategy in 21 patients with basilar artery dissection from January 2009 to July 2014 (17 men, four women; age range, 18-70 years; median age, 56 years). We divided patients into two groups: Group 1 patients received stent-assisted coiling treatment, and Group 2 patients received stent-only treatment. Pre-treatment, peri-operation and follow-up evaluation were investigated for complications, clinical outcome and angiographic results. The median follow-up time was 20 months (range, 3-67 months).All patients were treated endovascularly by stent-assisted coiling (14 patients) or stent only (seven patients). Immediate angiography showed: in Group 1, five of 14 lesions were completely occluded, five were partially occluded, four revealed retention of contrast media; in Group 2, all patients (seven of seven) had contrast retention. At the follow-up visit (median seven months, 3-29 months), the aneurysms were angiographically improved in five of 13 patients in Group 1 compared with immediately post-operation, while six of sevenimproved in Group 2. Five patients (all in Group 1) had ischemic or hemorrhage peri-operation complications. Long-term good clinical outcomes (modified Rankin Scale score (mRS) ≤ 2) were achieved in all patients except three death cases (two in Group1, one in Group 2).In our experience, endovascular reconstructive therapy using stents (with or without coiling) for basilar artery dissection is effective and safe. Stent-only treatment seems have a better safety profile during the peri-operation period. PMID:26842610

  2. Image-guided chemoport insertion by interventional radiologists: A single-center experience on periprocedural complications

    Yazmin Yaacob

    2013-01-01

    Full Text Available Purpose: To report our early experience in image-guided chemoport insertions by interventional radiologists. Materials and Methods: This was a cross-sectional study conducted in a tertiary center with 161 chemoport insertions done from June 2008 to June 2010. The chemoports were inserted either at the angiography suite or at the mobile operation theater unit. Ninety percent of the chemoports had right internal jugular vein (IJV as the entry site. Other entry sites included the left IJV, subclavian veins and the inferior vena cava. Immediate and early complications were recorded. All insertions were performed under image guidance with the aid of ultrasound and fluoroscopy. Results: The technical success rate was 99.4%. In terms of immediate complications, there were only two cases of arterial puncture that resolved with local compression. No pneumothorax or air embolism was documented. Twenty-six early complications were recorded. The most common early complication was catheter blockage (12/161; 7.4%, followed by catheter-related infection (9/161; 5.6%. Other complications were catheter malposition, venous thrombosis and catheter dislodgement or leak. A total of 11 (6.8% chemoports had to be removed within 30 days; most of them were due to infections that failed to respond to systemic antibiotic therapy. In terms of place of procedure, there were no significant differences in complication rates between the angiography suite and the mobile operation theater unit. Conclusion: Image-guided chemoport insertion by interventional radiologist gives low periprocedural complication rates. Using right IJV as the entry site, the image guidance gives good success rate with least complication.

  3. Comparison of endoscopic stenting for malignant biliaryobstruction: A single-center study

    2015-01-01

    AIM: To evaluate the efficacy and safety of single-stependoscopic placement of self-expandable metallic stents(SEMS) for treatment of obstructive jaundice.METHODS: A retrospective study was performedamong 90 patients who underwent transpapillarybiliary metallic stent placement for malignant biliaryobstruction (MBO) between April 2005 and October2012. The diagnosis of primary disease and MBO wasbased on abdominal ultrasound, computed tomography,magnetic resonance imaging, endoscopic ultrasound,endoscopic retrograde cholangiopancreatography withbrush cytology, biopsy, and/or a combination of thesemodalities. The type of SEMS (covered or non-covered,8 mm or 10 mm in diameter) was determined by theendoscopist. Ninety patients were divided into twogroups: group 1 (49 patients) who underwent a singlestepSEMS placement and group 2 (41 patients) whounderwent a two-step SEMS placement. The technicalsuccess rate, complication rate, stent patency, andpatient survival rate were compared between thegroups. In addition, to identify the clinical prognosticfactors associated with patient survival, the followingvariables were evaluated in Cox-regression analysis:gender, age, etiology of MBO (pancreatic cancer or nonpancreaticcancer), clinical stage (Ⅳb; with distant metastases or Ⅳa 〉; without distant metastases),chemotherapy (with or without), patency of the stent,and the use of single-step or two-step SEMS.RESULTS: Immediate technical success was achievedin 93.9% (46/49) in group 1 and in 95.1% (39/41)in group 2, with no significant difference (P = 1.0).Similarly, there was no difference in the complicationrates between the groups (group 1, 4.1% and group 2,4.9%; P = 0.62). Stent failure was observed in 10 casesin group 1 (20.4%) and in 16 cases in group 2 (39.0%).The patency of stent and patient survival revealed nodifference between the two groups with Kaplan-Meieranalysis, with a mean patency of 111 ± 17

  4. A single center series highlights on incidence and management of gastric neuroendocrine tumours with literature review

    Fahmy WF

    2015-06-01

    Full Text Available Neuroendocrine tumours of the digestive system (GEP-NET are relatively rare. Nevertheless, their diagnoses is rising as seen from studies in the US and elsewhere. Gastric neuroendocrine tumours (Gastric NETs vary through a wide clinical spectrum, from asymptomatic cases to functioning tumours. Gastrointestinal specialists need to be aware and pursue these lesions as they are indolent with a malignant variant and a potential for metastasis. A computerised search through our pathology laboratory data base, using codes for gastric, carcinoid and neuroendocrine tumour/ hyperplasia, was used to identify cases from January 2008 to September 2014. Medical charts were retrieved, examined. Eleven cases were identified and re-examined by one consultant pathologist. There were 5 females - mean age of 50 years (39-59 and 6 males - mean age of 57 years (41-73. Mean follow up period was 4.5 years (1-9. Gastric NETs fall into Type I, II and III (WHO Classification. Our series showed eight cases of Type I managed by biopsy/ endoscopic mucosal resection (EMR. No Type II cases were identified and one case of Type III had a subtotal gastrectomy and lymphadenectomy. Two neuroendocrine hyperplasia cases were managed by biopsy only. Cases were followed up (except one who refused with regular upper endoscopy and imaging as indicated. A literature review of managing Gastric NETs was discussed. We aim to alert gastrointestinal specialists by presenting a retrospective study of Gastric NETs from a single teaching institution.

  5. Design, operation, and safety of single-room interventional MRI suites: practical experience from two centers.

    White, Mark J; Thornton, John S; Hawkes, David J; Hill, Derek L G; Kitchen, Neil; Mancini, Laura; McEvoy, Andrew W; Razavi, Reza; Wilson, Sally; Yousry, Tarek; Keevil, Stephen F

    2015-01-01

    The design and operation of a facility in which a magnetic resonance imaging (MRI) scanner is incorporated into a room used for surgical or endovascular cardiac interventions presents several challenges. MR safety must be maintained in the presence of a much wider variety of equipment than is found in a diagnostic unit, and of staff unfamiliar with the MRI environment, without compromising the safety and practicality of the interventional procedure. Both the MR-guided cardiac interventional unit at Kings College London and the intraoperative imaging suite at the National Hospital for Neurology and Neurosurgery are single-room interventional facilities incorporating 1.5 T cylindrical-bore MRI scanners. The two units employ similar strategies to maintain MR safety, both in original design and day-to-day operational workflows, and between them over a decade of incident-free practice has been accumulated. This article outlines these strategies, highlighting both similarities and differences between the units, as well as some lessons learned and resulting procedural changes made in both units since installation. PMID:24497105

  6. Prevalence and severity of anemia in pediatric hemodialysis patients, a single center study

    Afshin Azhir

    2006-12-01

    Full Text Available BACKGROUNDS: This study was conducted to determine the prevalence and severity of anemia in children and adolescents on chronic hemodialysis, and to identify independent predictors of anemia in children on hemodialysis. METHODS: This cross-sectional study was performed between September 2005 and January 2006. The study population consisted of 25 patients aged 7−20 years on chronic hemodialysis from pediatric hemodialysis centers in Isfahan. RESULTS: A total of 22 (88% patients had hemoglobin levels of <11 g/dL (anemic and 12 patients (48% had hemoglobin levels of <8 g/dL (severe anemia. The mean age of these patients was 15.5 ± 3.7 years. Mean time on chronic dialysis was 20.44 ± 15.25 months. Anemia was more common and more severe among children who were on dialysis for less than 6 months. There was an inverse relationship between the severity of anemia and duration of hemodialysis (P = 0.019, r = – 0.465. Nearly all patients were treated with erythropoietin, Children with more severe anemia received slightly higher dose of erythropoietin (P = 0.09, r = 0.202. There was a significant difference between serum albumin values in anemic patients and patients without anemia (P = 0.023. There was a correlation between serum albumin and hemoglobin level (r = 0.511, P = 0.01. Intact PTH levels were >200 pg/ml in 16 patients (66% and >400 pg/ml in 9 patients (37. 5%. There was a reverse correlation between intact PTH level >200 pg/ml and hemoglobin level (r = -0.505, P = 0.046. CONCLUSIONS: The prevalence of anemia in hemodialysis children in Isfahan appears to be higher than that reported in the other studies in spite of extensive use of rHuEPO and iron supplementation. We found this to be especially true for patients new on hemodialysis (less than 6 months and in those with low albumin and severe hyperparathyroidism. KEY WORDS: Hemodialysis, anemia, children.

  7. Clinical Characteristics of Bowel Obstruction in Southern Iran; Results of a Single Center Experience

    Majid Akrami

    2015-01-01

    Full Text Available Objective: To determine the epidemiological, clinical, laboratory characteristics as well as outcome of 411 patients with bowel obstruction in Southern Iran. Methods: This was a cross-sectional study being performed in Shahid Faghihi hospital of Shiraz between 2006 and 2012. We reviewed the medical charts of the 411 patients with initial diagnosis of bowel obstruction who were admitted to our center during the study period. The patients’ demographic, clinical and laboratory findings as well as their management and outcome was recorded in data gathering forms. The data were then analyzed according to the outcome and clinical characteristics. Results: Among the 411 patients with initial diagnosis of bowel obstruction, 253 (61.5% were men and 158 (38.5% were women. The mean age of the patients was 48.2±19.7 years. Besides, 73.6% were observed and 26.4% were operated. Those who were operated had those who underwent operation had significantly lower frequency of obstipation (28.1% vs. 71.9%; p=0.045 and abdominal distention (32.3% vs. 67.7%; p=0.007. Intraoperative findings included adhesion band formation in 50 (48.1%, mass 18 (17.3%, and hernia 7 (6.7%. We found that the frequency of malignancy was significantly higher in those who were managed conservatively compared to those undergoing operation (64.3% vs. 35.7%; p=0.042. The mean hospital stay was significantly higher in those who underwent operation (8.1±7.5 vs. 2.6±2.2 days; p=0.035. Conclusion: The results of this study demonstrates although some signs and symptoms, such as abdominal pain, vomiting, abdominal tenderness, abdominal distention, and obstipation, were more common among the patients with bowel obstruction, they were not sensitive and specific enough for definite diagnosis. Due to the lack of positive predictive value of clinical signs and symptoms in diagnosis of bowel obstruction, a reasonable and logical modality is needed for bowel obstruction diagnosis with better

  8. New insights into the clinical evaluation of hereditary transthyretin amyloidosis patients: a single center's experience

    Suhr OB

    2012-08-01

    Full Text Available Ole B Suhr,1 Sandra Gustavsson,1 Victoria Heldestad,2 Rolf Hörnsten,3 Per Lindqvist,1 Erik Nordh,2 Urban Wiklund41Department of Public Health and Clinical Medicine, 2Department of Pharmacology and Clinical Neuroscience, 3Department of Surgical and Perioperative Sciences, Clinical Physiology, Heart Centre, 4Department of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, SwedenAbstract: Over the last decade, new medical treatment modalities have emerged based on increased insights into amyloid formation. With the increased possibilities for treatment of amyloidosis caused by transthyretin (TTR amyloid deposits comes the need for diagnostic procedures for early diagnosis and better tools to follow disease progression. This is of particular importance in clinical trials evaluating the efficacy of new treatments. Until recently, the treatment of TTR amyloidosis (ATTR was based solely on liver transplantation, a procedure that has halted disease progression in many patients. Liver transplantation has been especially effective in patients under the age of 50 years carrying the TTR V30M mutation, whereas the outcome of the procedure has been variable for others, particularly elderly male patients and those carrying a non-V30M mutation. This review concentrates on new insights derived from our center's experience with liver transplantation, how to implement this experience in evaluation of new treatment modalities for ATTR, and how to facilitate early diagnosis of neuropathy with easily available diagnostic tools. Attention has focused on manifestations of the disease that involve the heart and the peripheral nervous system; change in peripheral nerve function has been the primary endpoint in two controlled clinical trials, one finished and one ongoing. New insights into the amyloid formation process and the lessons learned from liver transplantation give the opportunity to design potentially effective treatment modalities for ATTR

  9. Conversion from temporary to tunneled catheters by nephrologists: report of a single-center experience

    Silva BC

    2016-04-01

    Full Text Available Bruno C Silva, Camila E Rodrigues, Regina CRM Abdulkader, Rosilene M Elias Nephrology Division, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil Background: Nephrologists have increasingly participated in the conversion from temporary catheters (TC to tunneled-cuffed catheters (TCCs for hemodialysis. Objective: To prospectively analyze the outcomes associated with TCC placement by nephrologists with expertise in such procedure, in different time periods at the same center. The impact of vancomycin or cefazolin as prophylactic antibiotics on the infection outcomes was also tested. Patients and methods: Hemodialysis patients who presented to such procedure were divided into two cohorts: A (from 2004 to 2008 and B (from 2013 to 2015. Time from TC to TCC conversion, prophylactic antibiotics, and reasons for TCC removal were evaluated. Results: One hundred and thirty patients were included in cohort A and 228 in cohort B. Sex, age, and follow-up time were similar between cohorts. Median time from TC to TCC conversion was longer in cohort A than in cohort B (14 [3; 30] vs 4 [1; 8] days, respectively; P<0.0001. Infection leading to catheter removal occurred in 26.4% vs 18.9% of procedures in cohorts A and B, respectively, and infection rate was 0.93 vs 0.73 infections per 1,000 catheter-days, respectively (P=0.092. Infection within 30 days from the procedure occurred in 1.4% of overall cohort. No differences were observed when comparing vancomycin and cefazolin as prophylactic antibiotics on 90-day infection-free TCC survival in a Kaplan–Meier model (log-rank = 0.188. TCC removal for low blood flow occurred in 8.9% of procedures. Conclusion: Conversion of TC to TCC by nephrologists had overall infection, catheter patency, and complications similar to data reported in the literature. Vancomycin was not superior to cefazolin as a prophylactic antibiotic. Keywords: renal dialysis, tunneled catheters, interventional nephrology

  10. Spectrum of intradialytic complications during hemodialysis and its management: A single-center experience

    Prabhakar

    2015-01-01

    Full Text Available Hemodialysis (HD is one of the important modalities of renal replacement therapy in acute renal failure (ARF as well as chronic renal failure (CRF. This study was performed to evaluate the various intradialytic complications that occur during HD and their management. This is a retrospective study performed in patients who underwent conventional HD during the period of 1 January 2000 to 31 December 2011 at our center. Clinical details, various complications faced and their management were retrieved from dialysis case sheets. A total of 2325 patients of renal failure (790 ARF and 1535 CRF patients were assessed for the intradialytic complications of HD. During the study period, there were 12,785 bicarbonate dialyses performed on these patients. In the ARF patients, the common intradialytic complications were: Hypotension, seen in 1296 sessions (30.4%, nausea and vomiting seen in 1125 sessions (26.4%, fever and chills seen in 818 sessions (19.2%, headache seen in 665 sessions (15.6%, cramps seen in 85 sessions (2.0%, chest pain and back pain seen in 82 sessions (1.92%, hypoglycemia seen in 77 sessions (1.8%, first-use syndrome seen in 72 sessions (1.7% and femoral hematoma seen in 31 sessions (0.73%. In the CRF group, common complications were hypotension in 2230 sessions (26.1%, nausea and vomiting in 1211 sessions (14.2%, fever and chills in 1228 sessions (14.4%, chest pain and back pain in 1108 cases (13.0%, hypertension in 886 sessions (10.4%, headache in 886 sessions (10.4%, cramps in 256 sessions (3.0%, hematoma in 55 sessions (0.64%, intracerebral hemorrhage in three sessions (0.03% and catheter tip migration in three sessions (0.03%. There is a need for special attention for the diagnosis and management of intradialytic complications of HD because such complications could be managed successfully without the need for termination of the dialysis procedure.

  11. Spontaneous Resolution of Vesicoureteral Reflux (VUR in Iranian Children, a Single Center Experience in 533 Cases

    M Sharifian

    2012-05-01

    Full Text Available

    Background and Objectives

    Experience with vesicoureteral reflux (VUR differs in different centers and there are lots of controversies surrounding this issue. The aim of this study was to evaluate Spontaneous resolution and prognosis of the disease among Iranian children.

     

    Methods

    In this case series study, 1278 children with urinary tract infection and visited at pediatric nephrology clinic in Tehran, Iran during 1999-2007 were studied. Primary VUR was found in 533 Patients. Following the diagnosis, the patients received prophylactic antibiotic and were annually followed with radionucleo cystography (RNC. Patients underwent surgery in case the medical treatment failed (breakthrough infection or new renal scar formation.

     

    Results

    533 patients with VUR were studied. Patients’ mean age with VUR was 3.7±2.4 years (range: 2 days to 18 years old. During an average follow-up duration of 3.3+2.2 years, spontaneous resolution was observed in 40% of 279 patients who had follow-up RNCs. The mean interval between VUR diagnosis and spontaneous resolution was 1.5+ 1 years (range: 2 months to 6 years. The resolution rate was decreased with increment of reflux grade so that for grades I to V, VUR was resolved in 63%, 57%, 27%, 22% and 10% of the cases, respectively. Anti reflux surgery was performed in 27(10% of patients during follow-up.

     

    Conclusion

    Based on the excellent results obtained from clinical therapy using low dose antibiotics, it is recommended that VUR grades 1 to 4 be managed medically with low-dose oral antibiotic prophylaxis and close follow-ups.

  12. Impact of hepatitis C infection on renal transplant patients: A single-center experience in Libya

    Abdel-Naser Y Elzouki

    2014-01-01

    Full Text Available The objective of this study was to assess the effect of hepatitis C virus (HCV infection on graft and patient survival in a cohort of Libyan renal transplant recipients. Medical records of 241 renal transplant (RT patients who have been followed-up at the Benghazi Nephrology Center up to February 2010 were reviewed. Based on the presence or absence of anti-HCV antibodies and HCV-RNA in the serum, patients were divided into two groups: HCV-positives and HCV-negatives. Anti-HCV antibodies were detected by the enzyme-linked immunosorbent assay technique and HCV-RNA by the polymerase chain reaction. Of the 241 RT patients, 162 were male and 79 were female. One hundred and ten patients (45.6% were HCV-positives and 131 (54.4% were HCV-negatives. Acute graft rejection was significantly higher among HCV-negative than HCV-positive patients (42 patients versus 28 patients, respectively; P < 0.001. Conversely, chronic graft rejection was higher among HCV-positives than that among HCV-negative patients (35 patients versus 24 patients, respectively; P <0.05, and this difference became more significant after a 12-month period of transplantation (P <0.01. Seventeen patients died during the follow-up: Seven HCV-positives (6.3% and 10 HCV-negatives (7.6%, and there was no significant difference in the death rate following RT between the two groups (P = 0.08. Among the seven deaths of HCV-positives, liver disease-related complications were the main cause of death in three (42.8% HCV-positive patients compared with none in the HCV-negative patients. The presence of HCV infection influenced chronic graft survival in RT patients and a higher proportion of HCV-infected patients had hepatic dysfunctions after RT. An increase in fatal liver complications was noted in HCV-positive patients with RT. In addition to pre-RT-specific therapy of HCV infection, all measures should be taken to prevent HCV infection pre- and post-RT. HCV-infected RT recipients need close

  13. Hypovitaminosis D in Patients Undergoing Shoulder Arthroplasty: A Single-Center Analysis.

    Inkrott, Bradley P; Koberling, Jessica L; Noel, Curtis R

    2016-07-01

    Vitamin D is recognized as an essential component in bone health, muscle function, and immune system regulation. This study sought to characterize the prevalence of hypovitaminosis D in patients undergoing total shoulder arthroplasty (TSA), reverse total shoulder arthroplasty (RSA), and shoulder hemiarthroplasty (HA). Between September 2013 and December 2014, a total of 218 patients undergoing TSA, RSA, and HA by a single surgeon were screened for hypovitaminosis D and retrospectively reviewed. Demographic variables and risk factors were recorded. Overall, 93 shoulder arthroplasty patients (43%) were vitamin D insufficient (<30 ng/mL) and 24 patients (11%) were vitamin D deficient (<20 ng/mL). Body mass index (BMI) had a significant effect on vitamin D levels; BMI of 30 kg/m(2) or greater was associated with lower vitamin D levels (31.5±12.1 ng/mL) compared with patients with a BMI of less than 30 kg/m(2) (36.2±15.7 ng/mL, P ≤.01). The absence of supplementation with vitamin D and calcium prior to serum testing was the most significant risk factor for hypovitaminosis D (odds ratio [OR], 8.234, P<.001). Age, gender, race, smoking status, American Society of Anesthesiologists (ASA) score, procedure, and surgical indication were not significant. This is the largest cohort of shoulder arthroplasty patients screened for hypovitaminosis D. Almost half (43%) of the study population was insufficient, and both the absence of supplementation prior to serum testing and BMI of 30 kg/m(2) or greater were found to be predictive of lower serum 25-hydroxyvitamin D levels. Given the extent of vitamin D involvement in normal musculoskeletal physiology, routine preoperative evaluation is merited. [Orthopedics. 2016; 39(4):e651-e656.]. PMID:27286046

  14. Endovascular Repair of Traumatic Rupture of the Thoracic Aorta: Single-Center Experience

    Purpose. Traumatic rupture of the thoracic aorta secondary to blunt chest trauma is a life-threatening emergency and a common cause of death, usually following violent collisions. The objective of this retrospective report was to evaluate the efficacy of endovascular treatment of thoracic aortic disruptions with a single commercially available stent-graft. Methods. Nine men (mean age 29.5 years) were admitted to our institution between January 2003 and January 2006 due to blunt aortic trauma following violent motor vehicle collisions. Plain chest radiography, spiral computed tomography, aortography, and transesophageal echocardiography were used for diagnostic purposes in all cases. All patients were diagnosed with contained extramural thoracic aortic hematomas, secondary to aortic disruption. One patient was also diagnosed with a traumatic thoracic aortic dissection, secondary to blunt trauma. All subjects were poor surgical candidates, due to major injuries such as multiple bone fractures, abdominal hematomas, and pulmonary contusions. All repairs were performed using the EndoFit (LeMaitre Vascular) stent-graft. Results. Complete exclusion of the traumatic aortic disruption and pseudoaneurysm was achieved and verified at intraoperative arteriography and on CT scans, within 10 days of the repair in all patients. In 1 case the deployment of a second cuff was necessary due to a secondary endoleak. In 2 cases the left subclavian artery was occluded to achieve adequate graft fixation. No procedure-related deaths have occurred and no cardiac or peripheral vascular complications were observed within the 12 months (range 8-16 months) follow-up. Conclusions. This is the first time the EndoFit graft has been utilized in the treatment of thoracic aortic disruptions secondary to chest trauma. The repair of such pathologies is technically feasible and early follow-up results are promising

  15. Cholangiocarcinoma: A 7-year experience at a single center in Greece

    Alexopoulou, Alexandra; Soultati, Aspasia; Dourakis, Spyros P; Vasilieva, Larissa; Archimandritis, Athanasios J

    2008-01-01

    AIM: To evaluate survival rate and clinical outcome of cholangiocarcinoma. METHODS: The medical records of 34 patients with cholangiocarcinoma, seen at a single hospital between the years 1999-2006, were retrospectively reviewed. RESULTS: Thirty-four patients with a median age of 75 years were included. Seventeen (50%) had painless jaundice at presentation. Sixteen (47.1%) were perihilar, 15 (44.1%) extrahepatic and three (8.8%) intrahepatic. Endoscopic retrograde cholangiography (ERCP) and/or magnetic resonance cholangiography (MRCP) were used for the diagnosis. Pathologic confirmation was obtained in seven and positive cytological examination in three. Thirteen patients had co-morbidities (38.2%). Four cases were managed with complete surgical resection. All the rest of the cases (30) were characterized as non-resectable due to advanced stage of the disease. Palliative biliary drainage was performed in 26/30 (86.6%). The mean follow-up was 32 mo (95% CI, 20-43 mo). Overall median survival was 8.7 mo (95% CI, 2-16 mo). The probability of 1-year, 2-year and 3-year survival was 46%, 20% and 7%, respectively. The survival was slightly longer in patients who underwent resection compared to those who did not, but this difference failed to reach statistical significance. Patients who underwent biliary drainage had an advantage in survival compared to those who did not (probability of survival 53% vs 0% at 1 year, respectively, P = 0.038). CONCLUSION: Patients with cholangiocarcinoma were usually elderly with co-morbidities and/or advanced disease at presentation. Even though a slight amelioration in survival with palliative biliary drainage was observed, patients had dismal outcome without resection of the tumor. PMID:18985813

  16. Single-center experience in pediatric renal transplantation using thymoglobulin induction and steroid minimization.

    Warejko, Jillian K; Hmiel, S Paul

    2014-12-01

    Our center has offered thymoglobulin induction with steroid minimization to our pediatric renal transplant patients for the last 10 yr. Steroid minimization or avoidance has shown favorable results in survival, kidney function, and growth in previous studies of pediatric patients. We report our experience with this protocol over the past 10 yr with respect to patient/graft survival, acute rejection episodes, renal function, linear growth, bone density, cardiovascular risk factors, and opportunistic infections. A retrospective chart review was performed for pediatric renal transplant patients on the steroid-minimized protocol between January 2002 and December 2011 on an intention to treat basis. Patient demographics, height, weight, serum creatinine, iGFR, biopsies, and survival data were collected. Height and weight z-scores were calculated with EpiInfo 7, using the CDC 2000 growth charts. Survival was calculated using Kaplan-Meier analysis. eGFR was calculated using the original and modified Schwartz equations. Forty-four pediatric patients were identified, aged 13 months to 19 yr. Five-yr survival was 95.5% for males and 94.4% for females. Only five patients had biopsy-proven ACR, two of which were at more than 12 months post-transplantation. Height delta z-scores from transplant to one, three, and five yr were 0.34, 0.38, and 0.79, respectively. Weight delta z-scores from transplant to one, three, and five yr were 0.87, 0.79, and 0.84, respectively. Mean original Schwartz eGFR was 84.3 ± 15.8 mL/min/1.73 m(2) , modified Schwartz eGFR was 59.3 ± 11.5 mL/min/1.73 m(2) , and iGFR was 64.2 ± 8.5 mL/min/1.73 m(2) at three yr. Of 18 subjects who had a bone density exam, none had a z-score less than -2 on DEXA exam at one-yr post-transplantation. Fifty-one percent of patients were on antihypertensives at the time of transplant compared with 43% at one-yr post-transplantation. Three yr post-transplantation, the average LDL was <100 mg/dL, and

  17. Hepatocellular carcinoma in Egypt: A single center study over a decade

    El-Zayadi, Abdel-Rahman; Badran, Hanaa M; Barakat, Eman MF; Attia, Mohy El-Deen; Shawky, Sherine; Mohamed, Mostafa K; Selim, Osaima; Saeid, Ahmed

    2005-01-01

    AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egypt over a decade. METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolled in the study. Diagnosis of HCC was based on histopathological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period I (1993-1997) and period II (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg, HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods. Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections. RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387) in periods I and II respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistoso-miasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods I and II respectively. HBV conferred a higher risk to develop HCC more than HCV in period I (OR 1.9 vs 1

  18. A review of 15 years full-scale seismic testing at the HDR

    The HDR Safety Program is carried out by the Karlsruhe Nuclear Research Center (KfK) on behalf of the German Federal Ministry for Research and Technology (BMFT). The Program has been subdivided into several Sub Projects according to the main activities in the field of Reactor Safety Research and actual questions of licensing procedure and public interest. This presentation deals with the earthquake investigations, exclusively. The general objective of the project is the experimental verification of calculation tools and procedures. To get an objective picture about the capability of design calculation methods, the activities within the whole program are usually carried out as a joint effort by various parties: while KfK is responsible for the performance of the experiments, data acquisition, comparisons and evaluations, the calculations are performed by specialized institutions. Here, the project management tries to maintain a reasonable balance between industrial participants, independent institutions and authorities responsible for the licensing of nuclear power plants. Besides the independence of the results obtained, this procedure has another advantage: the findings and conclusions of the evaluation process are directly transferred to the engineering community. (author)

  19. Liver transplant recipients with portal vein thrombosis:a single center retrospective study

    Yi-Feng Tao; Fei Teng; Zheng-Xin Wang; Wen-Yuan Guo; Xiao-Min Shi; Gui-Hua Wang; Guo-Shan Ding; Zhi-Ren Fu

    2009-01-01

    BACKGROUND: Portal vein thrombosis (PVT) used to be a contraindication for liver transplantation (LT). This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODS: A total of 465 adult LTs were performed from December 2002 through December 2006. Operative ifndings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading (Yerdel grading). Comparison of risk factors, variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. RESULTS: In the 465 LTs, 42 were operatively conifrmed to have PVT (9.0%) (19 recipients with grade 1, 14 with grade 2, 7 with grade 3, and 2 with grade 4). Increased age and treatment of portal hypertension were associated with PVT. Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy. In grade 3 PVT patients, the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed. Grade 4 PVT was managed by our modiifed cavoportal hemitransposition technique. The comparison between PVT patients and controls showed no signiifcant difference in operative duration and blood transfusion (P>0.05). The lfow rate of the PV was lower in the PVT patients (48.881±12.788 cm/s) than in the controls (57.172±21.715 cm/s,P0.05); the 3-year survival rates were 58.8% and 56.4%respectively (P>0.05). CONCLUSIONS: PVT is not contraindicated for LT if it is graded. PVT recipients may have post-transplantation complications like renal failure and PV rethrombosis, and operative dififculty and patient survival are similar to those in recipients without PVT

  20. (BB)-Carboryne Complex of Ruthenium: Synthesis by Double B-H Activation at a Single Metal Center.

    Eleazer, Bennett J; Smith, Mark D; Popov, Alexey A; Peryshkov, Dmitry V

    2016-08-24

    The first example of a transition metal (BB)-carboryne complex containing two boron atoms of the icosahedral cage connected to a single exohedral metal center (POBBOP)Ru(CO)2 (POBBOP = 1,7-OP(i-Pr)2-2,6-dehydro-m-carborane) was synthesized by double B-H activation within the strained m-carboranyl pincer framework. Theoretical calculations revealed that the unique three-membered (BB)>Ru metalacycle is formed by two bent B-Ru σ-bonds with the concomitant increase of the bond order between the two metalated boron atoms. The reactivity of the highly strained electron-rich (BB)-carboryne fragment with small molecules was probed by reactions with electrophiles. The carboryne-carboranyl transformations reported herein represent a new mode of cooperative metal-ligand reactivity of boron-based complexes. PMID:27526855

  1. AB INITIO STUDY OF THE POSSIBLE SINGLE-CENTER UNITS FOR BINUCLEAR IRON COMPLEX [Fe2(bpym3Cl4

    Tihonovschi Andrei

    2008-12-01

    Full Text Available In present work we study two possible single-center units for binuclear iron complex Fe2(bpym3Cl4 –[Fe(bpym3]2+ and Fe(bpym2Cl2. The obtained ground states for both studied systems are singlet states. In the case of Fe(bpym2Cl2 the lowest excited states were calculated to be 240cm-1 (triplet and 660cm-1 (quintet above the ground state and so are placed according to Lande rule. These states could be populated at room temperatures. For [Fe(bpym3]2+ first excited state was found to be about 6000cm-1 above the ground state and so cannot be populated at normal temperatures.

  2. Hospital Performance Indicators and Their Associated Factors in Acute Child Poisoning at a Single Poison Center, Central Saudi Arabia.

    Alanazi, Menyfah Q; Al-Jeriasy, Majed I; Al-Assiri, Mohammed H; Afesh, Lara Y; Alhammad, Fahad; Salam, Mahmoud

    2015-12-01

    Admission rate and length of stay (LOS) are two hospital performance indicators that affect the quality of care, patients' satisfaction, bed turnover, and health cost expenditures. The aim of the study was to identify factors associated with higher admission rates and extended average LOS among acutely poisoned children at a single poison center, central Saudi Arabia.This is a cross-sectional, poison and medical chart review between 2009 and 2011. Exposures were child characteristics, that is, gender, age, body mass index (BMI), health history, and Canadian 5-level triage scale. Poison incident characteristics were, that is, type, exposure route, amount, form, home remedy, and arrival time to center. Admission status and LOS were obtained from records. Chronic poisoning, plant allergies, and venomous bites were excluded. Bivariate and regression analyses were applied. Significance at P 1 h. Triage levels: non-urgent cases (58%), less urgent (11%), urgent (18%), emergency (12%), resuscitative (1%). Admission rate was (20.6%) whereas av. LOS was 13 ± 22 h. After adjusting and controlling for confounders, older children (adj.OR = 1.19) and more critical triage levels (adj.OR = 1.35) were significantly associated with higher admission rates compared to younger children and less critical triage levels (adj.P = 0.006) and (adj.P = 0.042) respectively. Home remedy prior arrival was significantly associated with higher av. LOS (Beta = 9.48, t = 2.99), compared to those who directly visited the center, adj.P = 0.003.Hospital administrators are cautioned that acutely poisoned children who received home remedies prior arrival are more likely to endure an extended LOS. This non-conventional practice is not recommended. PMID:26717371

  3. Maternal Tetanus at the University College Hospital in Ibadan Nigeria: A 15-Year Retrospective Analysis

    OA Roberts; IO Morhason-Bello; BO Adedokun; AO Adekunle

    2008-01-01

    Objective To determine the characteristics of women with maternal tetanus, pattern of presentation and outcome of management.Methods A total of 19 women were managed with maternal tetanus between 1990 and 2005 from the University College Hospital in Ibadan Nigeria. A retrospective study was performed. The medical records of all women managed as a case of maternal tetanus were retrieved from the central record department of the hospital The pattern of presentation, characteristics of women, the duration of hospital admission, tetanus toxoid immunization, and outcome of care were measured.Results The records of 18 women managed were analyzed. The mean age at presentation was 25.2±5.3 years. The patients were mostly single, nulliparous and had primary school education. The maternal tetanus cases seen mainly complicated induced abortion while 5 and 2 other cases were due to childbirth complication and leg wound respectively. The portal of entry of the remaining 3 cases could not be ascertained.None of the patient managed had complete immunization schedule. The average duration of admission was 11.2±6. 7 d. Five women had intensive care with 3 of them requiring ventilatory support. The case fatality rate was 66. 7%. The only factor that significantly improved survival was presence of generalized spasm at presentation (P=0. 006) Conclusion The occurrence of maternal tetanus is a reflection of low quality of health care delivery and lack or inefficient routine immunization coverage in any community.

  4. Effectiveness of 14-15 years old tennis players’ competition functioning considering correction of their psychological fitness

    Makuts T.B.

    2015-10-01

    Full Text Available Purpose: to determination influence of individualized psychological training on effectiveness of 14-15 years old tennis players’ competition functioning. Material: in the research 24 tennis players of 14-15 years’ age participated. Individualized psychological training consisted of 15 sessions of total duration of 1.5 months. Results: We substantiated necessity of individualized approach to tennis players’ psychological training. Individual psychological profiles for tennis players, which determined content of psychological training and their selection, were worked out. Informative indicators for assessment of 14-15 years old tennis players’ competition functioning were determined: 1 percentage of won and lost scores at the account of own actions; 2 integral criteria of tennis players’ competition functioning assessment (coefficient of stability and effectiveness; complex indicator of efficiency. Conclusions: it is recommended to consider individual potentials and bents of sportsmen in the course of psychological training.

  5. PHYSICAL ACTIVITY AND LEISURE TIME AMONG 13-15-YEAR-OLD TEENAGERS LIVING IN BIAŁA PODLASKA

    Grad Rafał

    2013-02-01

    Full Text Available The aim of the research was to get information about physical activity and forms of spending leisure time by teenagers between 13 and 15 years old, who live in Biała Podlaska. The research included 229 pupils from three Grammar Schools (115 girls and 114 boys. The range of respondents’ age is from 13 to 15 years old. The research tool was anonymous questionnaire consisting of questions concerning healthy lifestyle, physical activity and forms of spending leisure time. In total, the questionnaire consisted of 17 both open and close questions. On the basis of the questionnaire, it was proved that pupils’ knowledge on physical education and health is low (37-47% of correct answers. Young people more and more often choose passive forms of activity. Boys much more often take up active forms of exercise than girls. Teenagers devote most time to physical activity, the development of interests and taking care of one’s own appearance.

  6. Hyperbaric Oxygen Therapy in Branch Retinal Artery Occlusion in a 15-Year-Old Boy with Methylenetetrahydrofolate Reductase Mutation

    Ali Riza Cenk Celebi

    2015-01-01

    Full Text Available Purpose. To report the efficacy of hyperbaric oxygen (HBO therapy in a case of branch retinal artery occlusion (BRAO in a 15-year-old boy. Methods. We report a 15-year-old boy with sudden loss of vision due to BRAO. Examination included laboratory evaluation for systemic risk factors. Follow-up exams included visual acuity, fundus examination, fundus fluorescein angiography, and visual field testing. HBO therapy was employed for treatment. Results. Medical history was positive for isolated glucocorticoid deficiency. Laboratory evaluation disclosed hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR mutation. The visual acuity 0.05 at presentation improved to 0.8 after 20 days of HBO therapy. There was no change on visual fields. Conclusion. In this pediatric case, HBO therapy was useful in the treatment of BRAO.

  7. Effectiveness of 14-15 years old tennis players’ competition functioning considering correction of their psychological fitness

    Makuts T.B.

    2015-01-01

    Purpose: to determination influence of individualized psychological training on effectiveness of 14-15 years old tennis players’ competition functioning. Material: in the research 24 tennis players of 14-15 years’ age participated. Individualized psychological training consisted of 15 sessions of total duration of 1.5 months. Results: We substantiated necessity of individualized approach to tennis players’ psychological training. Individual psychological profiles for tennis players, which det...

  8. A POPULATION BASED STUDY OF REFRACTIVE ERRORS IN CHILDREN AMONG AGE GROUP OF 7-15 YEARS

    Dhanya; Pandu; Sujatha; Pallavi; Srinivas

    2016-01-01

    INTRODUCTION Refractive error is the most common cause of visual impairment around the world and the second leading cause of treatable blindness. Very early detection and treatment of visual impairment in children results in a reduction in the number of school children with poor sight being uncorrected. AIM To study the prevalence of uncorrected refractive errors among children of 7-15 years of age group. MATERIALS AND METHODS A total of 958 children of a...

  9. Hospitalization Incidence, Mortality, and Seasonality of Common Respiratory Viruses Over a Period of 15 Years in a Developed Subtropical City

    Chan, Paul K.S.; Tam, Wilson W.S.; Lee, Tsz Cheung; Hon, Kam Lun; Lee, Nelson; Martin C W Chan; Mok, Hing Yim; Wong, Martin C.S.; Leung, Ting Fan; Lai, Raymond W.M.; Yeung, Apple C.M.; Wendy C S Ho; Nelson, E. Anthony S.; Hui, David S. C.

    2015-01-01

    Abstract Information on respiratory viruses in subtropical region is limited. Incidence, mortality, and seasonality of influenza (Flu) A/B, respiratory syncytial virus (RSV), adenovirus (ADV), and parainfluenza viruses (PIV) 1/2/3 in hospitalized patients were assessed over a 15-year period (1998–2012) in Hong Kong. Male predominance and laterally transversed J-shaped distribution in age-specific incidence was observed. Incidence of Flu A, RSV, and PIV decreased sharply from infants to toddle...

  10. Bilateral pulmonary emboli after bilateral mastectomy in a 15-year-old boy with hypogonadism: A case report

    Piggott, JR; Yazdani, Arjang

    2010-01-01

    Pulmonary emboli are rare, yet serious, complications of body contouring surgery. When they occur, they more often follow as complications of long, invasive procedures in adults. The present report details a case of bilateral pulmonary emboli in an obese 15-year-old boy with hypogonadism undergoing bilateral mastectomy for gynecomastia. The diagnosis of bilateral pulmonary emboli was made on the basis of clinical presentation and positive ventilation/perfusion scan. The patient responded well...

  11. Rock alteration in alkaline cement waters over 15 years and its relevance to the geological disposal of nuclear waste

    Moyce, Elizabeth B.A.; Rochelle, Christopher; Morris, Katherine; Milodowski, Antoni E.; Chen, Xiaohui; Thornton, Steve; Small, Joe S.; Shaw, Samuel

    2014-01-01

    The interaction of groundwater with cement in a geological disposal facility (GDF) for intermediate level radioactive waste will produce a high pH leachate plume. Such a plume may alter the physical and chemical properties of the GDF host rock. However, the geochemical and mineralogical processes which may occur in such systems over timescales relevant for geological disposal remain unclear. This study has extended the timescale for laboratory experiments and shown that, after 15 years two di...

  12. Nutritional Transition in Children under Five Years and Women of Reproductive Age: A 15-Years Trend Analysis in Peru

    Loret de Mola, Christian; Quispe, Renato; Valle, Giancarlo A.; Julio A. Poterico

    2014-01-01

    Background Rapid urbanization, increase in food availability, and changes in diet and lifestyle patterns have been changing nutritional profiles in developing nations. We aimed to describe nutritional changes in children under 5 years and women of reproductive age in Peru, during a 15-year period of rapid economic development and social policy enhancement. Materials and Methods Trend analyses of anthropometric measures in children of preschool age and women between 15–49 years, using the Peru...

  13. Determinants of Subclinical Vitamin A Deficiency among children 1-5 years in a rural community of Jammu

    Shivali Suri; Dinesh Kumar

    2015-01-01

    Background: The burden of sub-clinical vitamin A deficiency (VAD), as evident by serum retinol levels, is huge (62%) among preschool children in India. Sub-clinical VAD increases children’s' susceptibility to infections, reduces physical growth and decreases the ability to survive from serious illnesses. Aims & Objectives: To assess the burden of subclinical VAD and study the various risk factors associated with it among children 1-5 years of age. Material Methods: A cross sectional commu...

  14. Between- and within-day variability in physical activity and inactivity in 9- and 15-year-old European children

    Nilsson, A; Anderssen, S A; Andersen, Lars Bo; Froberg, K; Riddoch, C; Sardinha, L B; Ekelund, U

    2008-01-01

    To examine differences in levels of physical activity (PA), time spent at moderate-to-vigorous intensity PA (MVPA) and time spent sedentary between and within days in children from four European countries, 1954 9 - and 15-year-olds were included. PA was measured during 2 weekdays and 2 weekend da...... targets when promoting PA in order to increase the proportion of children achieving current recommendations on health-enhancing PA....

  15. Prevalence of the developmental defects of the enamel in children aged 12–15 years in Kollam district

    Ravindran, Rathy; Saji, Ajish M.

    2016-01-01

    Aim and Objectives: To determine the prevalence of developmental defects of enamel in children aged 12–15 years in Kollam district and to examine the etiological factors associated with the developmental defects of the enamel (DDE). Materials and Methods: A total of 2,500 children from 10 urban and 10 rural schools were examined using modified DDE criteria for recording enamel defects. Ten index permanent teeth were screened for the DDE. Results: The overall prevalence of the DDE was found to...

  16. The Heritability of Psychopathic Personality in 14 to 15 year Old Twins: A Multi-Rater, Multi-Measure Approach

    Tuvblad, Catherine; Bezdjian, Serena; Raine, Adrian; Baker, Laura A.

    2014-01-01

    No study has yet examined the genetic and environmental influences on psychopathic personality across different raters and method of assessment. Participants were part of a community sample of male and female twins born between 1990 and 1995. The Child Psychopathy Scale (CPS) and the Antisocial Process Screening Device (APSD) were administered to the twins and their parents when the twins were 14 to 15 years old. The Psychopathy Checklist: Youth Version (PCL:YV) was administered and scored by...

  17. Slums from Space—15 Years of Slum Mapping Using Remote Sensing

    Monika Kuffer

    2016-05-01

    Full Text Available The body of scientific literature on slum mapping employing remote sensing methods has increased since the availability of more very-high-resolution (VHR sensors. This improves the ability to produce information for pro-poor policy development and to build methods capable of supporting systematic global slum monitoring required for international policy development such as the Sustainable Development Goals. This review provides an overview of slum mapping-related remote sensing publications over the period of 2000–2015 regarding four dimensions: contextual factors, physical slum characteristics, data and requirements, and slum extraction methods. The review has shown the following results. First, our contextual knowledge on the diversity of slums across the globe is limited, and slum dynamics are not well captured. Second, a more systematic exploration of physical slum characteristics is required for the development of robust image-based proxies. Third, although the latest commercial sensor technologies provide image data of less than 0.5 m spatial resolution, thereby improving object recognition in slums, the complex and diverse morphology of slums makes extraction through standard methods difficult. Fourth, successful approaches show diversity in terms of extracted information levels (area or object based, implemented indicator sets (single or large sets and methods employed (e.g., object-based image analysis (OBIA or machine learning. In the context of a global slum inventory, texture-based methods show good robustness across cities and imagery. Machine-learning algorithms have the highest reported accuracies and allow working with large indicator sets in a computationally efficient manner, while the upscaling of pixel-level information requires further research. For local slum mapping, OBIA approaches show good capabilities of extracting both area- and object-based information. Ultimately, establishing a more systematic relationship between

  18. Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience

    Hansen, C.R.; Pressler, T.; Høiby, Niels

    2008-01-01

    BACKGROUND: Since 1989, CF-patients intermittently colonized with Pseudomonas aeruginosa have been treated with inhaled colistin and oral ciprofloxacin in the Copenhagen CF-centre. The study evaluates 15 years results of this treatment. METHODS: All isolates of P. aeruginosa from CF-patients inte......BACKGROUND: Since 1989, CF-patients intermittently colonized with Pseudomonas aeruginosa have been treated with inhaled colistin and oral ciprofloxacin in the Copenhagen CF-centre. The study evaluates 15 years results of this treatment. METHODS: All isolates of P. aeruginosa from CF......-patients intermittently colonized with P. aeruginosa from 1989 to 2003 were identified All anti-P. aeruginosa treatments were evaluated for antibiotics used, treatment duration, pseudomonas-free interval and development of chronic infection. All P. aeruginosa isolates were assessed for resistance and for non-mucoid or...... to 80% of patients for up to 15 years. 613 colistin/ciprofloxacin treatments were given. There was no difference in pseudomonas-free interval comparing 3 weeks (5 months) and 3 months (10.4 months) of colistin and ciprofloxacin, but a significant difference compared to no treatment (1.9 months...

  19. Antibiotic prescribing of village doctors for children under 15 years with upper respiratory tract infections in rural China: A qualitative study.

    Zhang, Zhixia; Zhan, Xingxin; Zhou, Hongjun; Sun, Fang; Zhang, Heng; Zwarenstein, Merrick; Liu, Qian; Li, Yingxue; Yan, Weirong

    2016-06-01

    The aim of this study was to explore the knowledge, attitudes, and practices of village doctors regarding the prescribing of antibiotics for children under 15 years with upper respiratory tract infections (URTIs) in rural China. Twelve focus group discussions (FGDs) were conducted in Xianning, a prefecture-level city in rural China, during December 2014. We conducted 6 FGDs with 35 village doctors, 3 with 13 primary caregivers (11 parents), and 3 with 17 directors of township hospitals, county-level health bureaus, county-level Centers for Disease Control and Prevention, or county-level Chinese Food and Drug Administration offices. Audio records of the interviews were transcribed verbatim and analyzed using the thematic analysis approach. Participants believed that unnecessary antibiotic prescribing for children under 15 years with The occurrence of URTIs was a problem in village clinics in rural China. The discussions revealed that most of the village doctors had inadequate knowledge and misconceptions about antibiotic use, which was an important factor in the unnecessary prescribing. Village doctors and directors reported that the doctors' fear of complications, the primary caregivers' pressure for antibiotic treatment, and the financial considerations of patient retention were the main factors influencing the decision to prescribe antibiotics. Most of the primary caregivers insisted on antibiotics, even when the village doctors were reluctant to prescribe them, and they preferred to go to see those village doctors who prescribed antibiotics. The interviewees also gave their opinions on what would be the most effective measures for optimizing antibiotic prescriptions; these included educational/training campaigns, strict regulations on antibiotic prescription, and improved supervision. Findings emphasized the need to improve the dissemination of information and training/education, and implement legislation on the rational use of antibiotics. And it also provided

  20. Hepatitis B virus is still the most common etiologic factor of liver cirrhosis: Results from a single center in Turkey

    Sebahat Başyigit

    2015-12-01

    Full Text Available Objective: It is important to examine the epidemiology of liver cirrhosis (LC because of it is a preventable disease. In this single-center study, we aimed to determine the epidemiological characteristics and etiology of LC in Central Anatolian region of Turkey. Methods: We reviewed data of patients with liver cirrhosis who presented to outpatient and inpatient clinics of our medical center between January 1, 2011 and September 31, 2014 Results: Overall, 135 patients were included to the study: 91 men (67.4% and 44 women (33% with a mean age of 63±14,3 years (range: 15–87years. The primary causes of cirrhosis were chronic hepatitis B (CHB (n: 52, 38.5% and cryptogenic cirrhosis (n: 33, 24.4%. CHB was the main etiology of cirrhosis in men (49.5% and cryptogenic LC was predominant in women (40.9%. Patients with alcoholic cirrhosis were solely male. Percentage of patients with autoimmune hepatitis was significantly higher among women (70%. The percentage of patients with HBV was similar between patients aged50 years (31.6% and 39.7%, respectively, but percentage of patients with hepatitis C virus was lower (5.3% in patients aged50 years (14.7%. There was no cirrhotic patients under 50 years of age due to a genetic disorder Conclusion: Despite national vaccination program, effective treatment regimens and intensive screening methods against hepatitis B virus, it remains to be the most common cause of LC in our country.

  1. Spectroscopic study of red-light-emitting centers in K2Al2B2O7: Fe single crystals

    Ogorodnikov, I. N.; Pustovarov, V. A.; Yakovlev, S. A.; Isaenko, L. I.

    2013-04-01

    We report on spectroscopic study of red-light-emitting centers in K2Al2B2O7 (KABO) single crystals containing ca. 2 ppm of Fe3+. Owing to the low Fe3+-concentration, KABO does not show noticeable absorption due to Fe3+d-d-transitions in the visible spectral region, but it exhibits the charge-transfer (CT) UV-absorption bands O-Fe at 4.7, 5.7 and 6.5 eV. The red photoluminescence at 1.675 eV (FWHM = 0.173 eV) is due to intracenter 4T1 (4G) → 6A1 (6S) transitions in Fe3+ ions. Because of partial overlapping of the fundamental absorption edge of the crystal, where mobile excitons are created, and a broad CT absorption band at 6.5 eV, the most intensive red emission occurs at 7 K upon excitation in the excitonic energy region. The presence of two nonequivalent Al2O7 clusters in KABO lattice provides two different types of red-light-emitting centers in the form of Fe3+ ion occupied the Al3+ tetrahedral site. Superposition of their luminescence bands determines both the spectrum and temperature dependence of red emission in KABO at T = 7-80 K: two bands with the ratio of intensities of ca. 2:1 are 20 meV-shifted relative to each other; two-stage thermal quenching obeys the Mott law with ET = 9 and 20 meV.

  2. Control of coherence among the spins of a single electron and the three nearest neighbor 13C nuclei of a nitrogen-vacancy center in diamond

    Individual nuclear spins in diamond can be optically detected through hyperfine couplings with the electron spin of a single nitrogen-vacancy (NV) center; such nuclear spins have outstandingly long coherence times. Among the hyperfine couplings in the NV center, the nearest neighbor 13C nuclear spins have the largest coupling strength. Nearest neighbor 13C nuclear spins have the potential to perform fastest gate operations, providing highest fidelity in quantum computing. Herein, we report on the control of coherences in the NV center where all three nearest neighbor carbons are of the 13C isotope. Coherence among the three and four qubits are generated and analyzed at room temperature

  3. Control of coherence among the spins of a single electron and the three nearest neighbor {sup 13}C nuclei of a nitrogen-vacancy center in diamond

    Shimo-Oka, T.; Miwa, S.; Suzuki, Y.; Mizuochi, N., E-mail: mizuochi@mp.es.osaka-u.ac.jp [Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531 (Japan); Kato, H.; Yamasaki, S. [Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568 (Japan); Jelezko, F. [Institut für Quantenoptik, Universität Ulm, Albert-Einstein-Allee 11, 89081 Ulm (Germany)

    2015-04-13

    Individual nuclear spins in diamond can be optically detected through hyperfine couplings with the electron spin of a single nitrogen-vacancy (NV) center; such nuclear spins have outstandingly long coherence times. Among the hyperfine couplings in the NV center, the nearest neighbor {sup 13}C nuclear spins have the largest coupling strength. Nearest neighbor {sup 13}C nuclear spins have the potential to perform fastest gate operations, providing highest fidelity in quantum computing. Herein, we report on the control of coherences in the NV center where all three nearest neighbor carbons are of the {sup 13}C isotope. Coherence among the three and four qubits are generated and analyzed at room temperature.

  4. Prevalence of dental caries and dental fluorosis among 12 and15 year-old school children in an endemic fluoride area of Nalgonda district, Andhra Pradesh, India

    Jagadeeswara Rao Sukhabogi

    2013-01-01

    Full Text Available Introduction: The published literature on the prevalence of dental caries and fluorosis in Nalgonda district, an endemic fluoride belt in India was scanty. Objective: To determine the prevalence of dental caries and dental fluorosis among 12 and 15 years old school children in relation to fluoride concentration in Nalgonda district. Materials and Methods: Stratified random sampling technique was employed to select 20 schools from Nalgonda district. These areas were divided into four categories, low, medium, high and very high fluoride areas based on the fluoride concentration. The oral examination for dental caries and fluorosis among children who fulfilled the inclusion and exclusion criteria were conducted by a single trained and calibrated examiner using mouth mirror and CPI (Community Periodontal Index probe under natural daylight. The data analysis was done using Statistical Package for Social Sciences SPSS version 16. Results: The prevalence of dental caries among 12 and 15 year old school children was 42.6% and 48.6% respectively. The prevalence was more among females (56.9% than males (34.2%. The prevalence was more in low fluoride area (67% followed by very high fluoride area (56.1%. The lowest prevalence was in medium fluoride area (20.5%. The prevalence of dental fluorosis increased with increasing fluoride concentration with no difference in the gender and age distribution. Conclusion: Defluoridation of water in areas where the concentration of fluoride is more than optimal is an immediate need as dental fluorosis is a major public health problem in these areas.

  5. Clinical epidemiological profile of leprosy in children under 15 years in the city of Juazeiro-BA

    Igara Cavalcanti Feitosa Luna

    2014-04-01

    Full Text Available Objective: To describe the clinical and epidemiological profile of new cases of leprosy in people aged under 15 years, reported to the Municipal Department of Health (Secretaria Municipal de Saúde - SMS of Juazeiro-BA, in the period from 2001 to 2010. Methods: This is a quantitative study, of exploratory and descriptive nature, performed through the analysis of data contained in the Information System for Notifiable Diseases (Sistema de Informação de Agravos de Notificação - SINAN, in municipal level. Results: The results showed that 145 (7.94% new cases of leprosy affected people under 15 years. High detection rates were verified for this age group, with predominance in females (n=81; 55.86% and greater occurrence in the age group from 10 to 14 years (n=85; 58.62%. The paucibacillary forms (n=107; 74.48% have predominated over the multibacillary forms of the disease (n=37; 25.52%, being the tuberculoid clinical form (n=80; 55.17% the most prevalent one. The disabilities reached 18 (12.41% of the surveyed patients at the diagnosis time and 15 (10.34% at the hospital discharge time. Many of the cases (n=58; 40.07% were not assessed or were ignored. Conclusion: The clinical and epidemiological profile of the occurrence of new cases of leprosy in Juazeiro-BA showed that both the overall detection coefficients of leprosy as those for people aged under 15 years remained at hyperendemic levels during the surveyed period. doi:10.5020/18061230.2013.p208

  6. A POPULATION BASED STUDY OF REFRACTIVE ERRORS IN CHILDREN AMONG AGE GROUP OF 7-15 YEARS

    Dhanya

    2016-03-01

    Full Text Available INTRODUCTION Refractive error is the most common cause of visual impairment around the world and the second leading cause of treatable blindness. Very early detection and treatment of visual impairment in children results in a reduction in the number of school children with poor sight being uncorrected. AIM To study the prevalence of uncorrected refractive errors among children of 7-15 years of age group. MATERIALS AND METHODS A total of 958 children of age group 7-15 years were examined during a time period of 1 year from June 2014 to May 2015. The examination included visual acuity, slit lamp examination, auto refractometer, keratometry, A-Scan Biometry and fundoscopic examination. Patients were then taken to assess the refractive error under the cycloplegic effect of 1% homatropine by streak retinoscopy. Hyperopia was defined as spherical power of >+2.00 D, Myopia as -0.50 D. RESULTS Visual impairment (VA of 6/12 or worse in better eye was present in 8.14% of the children examined. The prevalence of myopia, hypermetropia and astigmatism was 4.70%, 1.24%, 2.2% respectively, Myopia was commonly seen in older age group children. CONCLUSION Refractive error was the main cause of visual impairment in children between 7-15 years. Myopia was the most common refractive error particularly in older children. Uncorrected refractive errors among children have a considerable impact on learning and their academic achievement. Diagnosis and correction of refractive error is the most effective form of eye care. As it is an easily treatable cause of visual impairment, effective strategies should be developed to eliminate refractive error in children.

  7. Chemical, Colour and Strength Changes of Eco-friendly Hot Oil Treatment on 15 Year-old Cultivated Acacia Hybrid

    Razak Wahab; Othman Sulaiman; Izyan Khalid; Mohd Sukhairi Mat Rasat; Mahmud Sudin

    2013-01-01

    The chemical, colour and strength properties of thermally modified cultivated 15-year-old Acacia hybrid were investigated. Logs of A. hybrid were harvested and cut at the bottom, middle and top sections. The wood later underwent hot oilthermal modification using palm oil at temperatures 180°C, 200°C and 220°C for 30, 60 and 90 min. Untreated wood was used as control. The hot oil thermal modification process caused some features changed in the chemical composition, colour appearances and stren...

  8. DAILY PHYSICAL ACTIVITY AND PHYSICAL FITNESS IN 11-TO 15-YEAR-OLD TRAINED AND UNTRAINED TURKISH BOYS

    Alpay Güvenç; Caner Açıkada; Alper Aslan; Kamil Özer

    2011-01-01

    The aims of this study were to assess levels and patterns of physical activity (PA) in relation to age and regular sport activity, and to examine its relationship to physical fitness in trained and untrained boys. One hundred forty-seven 11-to 15- year-old boys (73 trained and 74 untrained) participated in this study. Trained boys, comprised of 26 soccer, 25 handball and 22 volleyball players, had been training regularly for at least one year. The intensity, duration and frequency of PA were ...

  9. Comparison of interventionist, motion and rehabilitation method in Pilates and yoga by mentally disabled children aged 8-15 years.

    Kroupová, Petra

    2013-01-01

    Bachelor´s work deals with a comparison of the intervention kinetic and rehabilitation method of Pilates and yoga and its´ influence on 8-15 years old children with mental disability. Dur?ing all the period, an influence of these kinetic activities on the health and value orientation of the proband was observed. The aim of the work was the creation of kinetic program focused on mental disabled children, where for one proband group the Pilates kinetic method was ap?plied and for the second gro...

  10. Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy.

    Camila Fernandes

    Full Text Available BACKGROUND: Leprosy is a chronic disease, caused by Mycobacterium leprae, which poses a serious public health problem worldwide. Its high incidence in people under 15 years old in Ceará state, Brazil, reflects the difficulty of its control. The spectrum of clinical manifestations is associated with the immune response developed, with the Th1 and Th2 responses being related to the paucibacillary and multibacillary forms, respectively. Regulatory T cells (Treg, which can suppress Th1 and Th2 response, have received special attention in the literature and have been associated with development of chronic infections. However, their role in leprosy in individuals under 15 years old has not yet been elucidated. We evaluated the frequency of CD4(+/CD8(+CD25(highFOXP3(+ and CD4(+/CD8(+CD25(highFOXP3(high cells in leprosy patients and household contacts, in both cases under 15 years old. METHODOLOGY/PRINCIPAL FINDINGS: PBMC from 12 patients and 17 contacts were cultured for 72 hours with anti-CD3 and anti-CD28 (activators or with activators associated with total sonicated fraction of M. leprae. After culture, the frequency of CD4(+/CD8(+ Treg was identified by flow cytometry. Cells stimulated by activators and antigen from multibacillary patients showed Treg frequencies almost two times that of the contacts: CD4(+FOXP3(+ (21.93±8.43 vs. 13.79±8.19%, p = 0.0500, CD4(+FOXP3(high (10.33±5.69 vs. 5.57±4.03%, p = 0.0362, CD8(+FOXP3(+ (13.88±9.19 vs. 6.18±5.56%, p = 0.0230 and CD8(+FOXP3(high (5.36±4.17 vs. 2.23±2.68%, p = 0.0461. Furthermore, the mean fluorescence intensity of FOXP3 in Treg was higher in multibacillary patients than in the contacts. Interestingly, there was a positive correlation of the bacillary index and number of lesions with the frequency of all Treg evaluated in patients. CONCLUSIONS/SIGNIFICANCE: We have demonstrated for the first time that multibacillary leprosy patients under 15 years old have greater CD4(+ and

  11. Rock alteration in alkaline cement waters over 15 years and its relevance to the geological disposal of nuclear waste

    Highlights: • Rock alteration in chemically disturbed zone of a nuclear waste geodisposal facility. • Experiments conducted for 15 years at 70 °C. • Initially formed C–S–H phases destabilise during longer-term reaction. • Dedolomitisation leads to formation of Mg–silicates, the dominant secondary phases. • Rock alteration leads to increased U(VI) sorption capacity. - Abstract: The interaction of groundwater with cement in a geological disposal facility (GDF) for intermediate level radioactive waste will produce a high pH leachate plume. Such a plume may alter the physical and chemical properties of the GDF host rock. However, the geochemical and mineralogical processes which may occur in such systems over timescales relevant for geological disposal remain unclear. This study has extended the timescale for laboratory experiments and shown that, after 15 years two distinct phases of reaction may occur during alteration of a dolomite-rich rock at high pH. In these experiments the dissolution of primary silicate minerals and the formation of secondary calcium silicate hydrate (C–S–H) phases containing varying amounts of aluminium and potassium (C–(A)–(K)–S–H) during the early stages of reaction (up to 15 months) have been superseded as the systems have evolved. After 15 years significant dedolomitisation (MgCa(CO3)2 + 2OH− → Mg(OH)2 + CaCO3 + CO32−(aq)) has led to the formation of magnesium silicates, such as saponite and talc, containing variable amounts of aluminium and potassium (Mg–(Al)–(K)–silicates), and calcite at the expense of the early-formed C–(A)–(K)–S–H phases. This occured in high pH solutions representative of two different periods of cement leachate evolution with little difference in the alteration processes in either a KOH and NaOH or a Ca(OH)2 dominated solution but a greater extent of alteration in the higher pH KOH/NaOH leachate. The high pH alteration of the rock over 15 years also increased the

  12. Pulmonary Atypical Carcinoid Tumor in a 15-Year-Old Girl: a Case Report and Review of the Literature

    Geramizadeh, Bita; Reza Foroutan, Hamid; Shokripour, Mansoureh; Reza Dehghanian, Amir

    2013-01-01

    Primary pulmonary neoplasms in children are very rare, and because of their rarity, delays in diagnosis and treatment are common. Bronchial typical carcinoid accounts for 80% of primary malignant tumors, but, there are less than 40 proven cases in children reported in literature. Atypical carcinoids (AC) are the least common type of pulmonary carcinoids among children and to the best of our knowledge less than 10 cases have been reported in the English literature so far. Herein we present an extremely rare case of AC in a 15-year-old child and review the previously reported and published cases of pulmonary AC in pediatric age group. PMID:24179657

  13. Pulmonary atypical carcinoid tumor in a 15-year-old girl: a case report and review of the literature

    Bita Geramizadeh

    2013-09-01

    Full Text Available Primary pulmonary neoplasms in children are very rare, and because of their rarity, delays in diagnosis and treatment are common. Bronchial typical carcinoid accounts for 80% of primary malignant tumors, but, there are less than 40 proven cases in children reported in literature. Atypical carcinoids (AC are the least common type of pulmonary carcinoids among children and to the best of our knowledge less than 10 cases have been reported in the English literature so far. Herein we present an extremely rare case of AC in a 15-year-old child and review the previously reported and published cases of pulmonary AC in pediatric age group.

  14. Elevated BUBR1 Expression Is Associated with Poor Survival in Early Breast Cancer Patients: 15-Year Follow-up Analysis

    Maciejczyk, Adam; Szelachowska, Jolanta; Czapiga, Bogdan; Matkowski, Rafał; Hałoń, Agnieszka; Györffy, Balázs; Surowiak, Paweł

    2013-01-01

    BUBR1 (budding uninhibited by benzimidazole-related 1) represents the component of a controlling complex in mitosis. Defects in mitotic control complex result in chromosomal instability and, as a result, disturb the mitotic process. This study was aimed at examining the prognostic value linked to the expression of BUBR1 in a group of patients with breast cancer. We analyzed the expression of BUBR1 in 98 stage II breast cancer patients with a median follow-up of 15 years. Immunohistochemical r...

  15. Insulation Failure of the Linox Defibrillator Lead: A Case Report and Retrospective Review of a Single Center Experience.

    Howe, Andrew J; McKeag, Nicholas A; Wilson, Carol M; Ashfield, Kyle P; Roberts, Michael J

    2015-06-01

    Implantable cardioverter defibrillator (ICD) lead insulation failure and conductor externalization have been increasingly reported. The 7.8F silicon-insulated Linox SD and Linox S ICD leads (Biotronik, Berlin, Germany) were released in 2006 and 2007, respectively, with an estimated 85,000 implantations worldwide. A 39-year-old female suffered an out-of-hospital ventricular fibrillation (VF) arrest with successful resuscitation. An ICD was implanted utilizing a single coil active fixation Linox(Smart) S lead (Biotronik, Berlin, Germany). A device-triggered alert approximately 3 years after implantation confirmed nonphysiological high rate sensing leading to VF detection. A chest X-ray showed an abnormality of the ICD lead and fluoroscopic screening confirmed conductor externalization proximal to the defibrillator coil. In view of the combined electrical and fluoroscopic abnormalities, urgent lead extraction and replacement were performed. A review of Linox (Biotronik) and Vigila (Sorin Group, Milan, Italy) lead implantations within our center (n = 98) identified 3 additional patients presenting with premature lead failure, 2 associated with nonphysiological sensed events and one associated with a significant decrease in lead impedance. All leads were subsequently removed and replaced. This case provides a striking example of insulation failure affecting the Linox ICD lead and, we believe, is the first to demonstrate conductor externalization manifesting both electrical and fluoroscopic abnormalities. PMID:25711237

  16. Urinary tract infection in children after cardiac surgery: Incidence, causes, risk factors and outcomes in a single-center study.

    Kabbani, Mohamed S; Ismail, Sameh R; Fatima, Anis; Shafi, Rehana; Idris, Julinar A; Mehmood, Akhter; Singh, Reetam K; Elbarabry, Mahmoud; Hijazi, Omar; Hussein, Mohamed A

    2016-01-01

    Nosocomial urinary tract infection (UTI) increases hospitalization, cost and morbidity. In this cohort study, we aimed to determine the incidence, risk factors, etiology and outcomes of UTIs in post-operative cardiac children. To this end, we studied all post-operative patients admitted to the Pediatric Cardiac Intensive Care Unit (PCICU) in 2012, and we divided the patients into two groups: the UTI (UTI group) and the non-UTI (control group). We compared both groups for multiple peri-operative risk factors. We included 413 children in this study. Of these, 29 (7%) had UTIs after cardiac surgery (UTI group), and 384 (93%) were free from UTIs (control group). All UTI cases were catheter-associated UTIs (CAUTIs). A total of 1578 urinary catheter days were assessed in this study, with a CAUTI density rate of 18 per 1000 catheter days. Multivariate logistic regression analysis demonstrated the following risk factors for CAUTI development: duration of urinary catheter placement (pcongenital abnormalities of kidney and urinary tract (CAKUT) (purinary catheter, the presence of CAKUT, and the presence of syndromes comprised the main risk factors for CAUTI. Gram-negative organisms were the main causes for CAUTI, and one-third of them found to be resistant in this single-center study. PMID:26829892

  17. Validation of four different risk stratification models in patients undergoing heart valve surgery in a single center in China

    ZHANG Chun-xiao; XU Jian-ping; GE Yi-peng; WEI Yu; YANG Yan; LIU Feng; SHI Yi

    2011-01-01

    Background Several risk stratification models have been developed for cardiac surgery. This study aimed to evaluate the accuracy of four existing risk stratification models, the Fuwai System for Cardiac Operative Risk Evaluation (FuwaiSCORE), the Society of Thoracic Surgeons 2008 cardiac surgery risk model for isolated valve surgery (the STS model), the European System for Cardiac Operative Risk Evaluation (EuroSCORE) and the initial Parsonnet's score (the Parsonnet model) in predicting prolonged intensive care unit (ICU) stay in Chinese patients undergoing heart valve surgery. Methods Data were collected retrospectively from records of 1333 consecutive patients who received heart valve surgery in a single center between November 2006 and December 2007. Prolonged ICU stay was defined as not less than 124 hours. Calibration was assessed using the Hosmer-Lemeshow (H-L) goodness of fit test. Discrimination was assessed using the receiver-operating-characteristic (ROC) curve area. Results The FuwaiSCORE showed good calibration and discrimination compared with other risk models. According to the H-L statistics, the value of the FuwaiSCORE was 12.82, P>0.1. The area under ROC curve of the FuwaiSCORE was 0.81 (95%C/0.78-0.84). Conclusions Our study suggests that the FuwaiSCORE is superior to the other three risk models in predicting prolonged length of ICU stay in Chinese patients with heart valve surgery. Having fewer variables, the system is much easier for bedside use than other systems.

  18. Donor safety in adult living donor liver transplantation using the right lobe:Single center experience in China

    Fu-Gui Li; Lu-Nan Yan; Yong Zeng; Jia-Yin Yang; Qi-Yuan Lin; Xiao-Zhong Jiang; Bin Liu

    2007-01-01

    AIM: To evaluate the safety of donors in adult living donor liver transplantation (LDLT) using the right lobe in a single liver transplantation center in China.METHODS: We investigated retrospectively 52 living donor liver resections performed from October 2003 to July 2006. All patients were evaluated by blood tests and abdominal CT. The mean donor age was 28.2±7.4years. Residual liver volume was 42.1%±4.7%. Mean operative time was 420±76.2 min; mean ICU stay, less than 36 h; mean hospital stay, 16.4±8.6 d; and mean follow-up period, 6 mo.RESULTS: There was no mortality. The overall complication rate was 40% (21 donors). Major complications included biliary leak in two, and pneumonia in 2 donors. Minor complications included mild pleural effusion in 12 donors, transient ascites in 6, mild depression in 4, intra-abdominal collections in 2,and wound infections in 1 donor. Residual liver volume did not affect the complication rate. None required reoperation. Return to pre-donation activity occurred within 5-8 wk.CONCLUSION: Right hemi-hepatectomy can be performed safely with minimal risk in cases of careful donor selection. Major complications occurred in only 7.7% of our series.

  19. Outcomes Following Iodine-125 Monotherapy for Localized Prostate Cancer: The Results of Leeds 10-Year Single-Center Brachytherapy Experience

    Purpose: This study reports the 10-year experience of permanent brachytherapy monotherapy at a single UK center. Methods and Materials: Between March 1995 and September 2004, 1,298 patients underwent trans-rectal ultrasound (TRUS) planned transperineal brachytherapy delivering 145 Gy using I-125. No patient received supplemental external beam; 44.2% received neoadjuvant hormones. In 688, CT postimplant dosimetry was available. Outcome data were analyzed in terms of overall survival (OS), disease specific survival (DSS), and PSA relapse-free survival (PSA-RFS). Results: The mean age was 62.9 (range, 34-83) years. Median follow-up was 4.9 years (range, 2.03-11.7 years). OS and DSS were 85% and 95%, respectively, at 10 years. Twenty-one patients died from prostate cancer (1.6%) and 34 (2.5%) from unrelated causes. Seventy-four (5.7%) developed evidence of clinical failure. Overall PSA-RFS was 79.9% and 72.1% at 10 years (American Society for Therapeutic Radiology and Oncology [ASTRO] and Nadir+2 definitions, respectively). Higher presenting PSA or Gleason score and use of neoadjuvant hormones were associated with an increased risk of biochemical failure (p 90 ≥140 Gy and in 78% of patients with D90 90 with biochemical control.

  20. Acute Renal Replacement Therapy in Children with Diarrhea-Associated Hemolytic Uremic Syndrome: A Single Center 16 Years of Experience

    Silviu Grisaru

    2011-01-01

    Full Text Available Acute kidney injury (AKI is becoming more prevalent among hospitalized children, its etiologies are shifting, and new treatment modalities are evolving; however, diarrhea-associated hemolytic uremic syndrome (D+HUS remains the most common primary disease causing AKI in young children. Little has been published about acute renal replacement therapy (ARRT and its challenges in this population. We describe our single center's experience managing 134 pediatric patients with D+HUS out of whom 58 (43% required ARRT over the past 16 years. In our cohort, all but one patient were started on peritoneal dialysis (PD. Most patients, 47 (81%, received acute PD on a pediatric inpatient ward. The most common recorded complications in our cohort were peritoneal fluid leaks 13 (22%, peritonitis 11 (20%, and catheter malfunction 5 (9%. Nine patients (16% needed surgical revision of their PD catheters. There were no bleeding events related to PD despite a mean platelets count of 40.9 (±23.5 × 103/mm3 and rare use of platelets infusions. Despite its methodological limitations, this paper adds to the limited body of evidence supporting the use of acute PD as the primary ARRT modality in children with D+HUS.

  1. Polyethylene Glycol Electrolyte Lavage Solution versus Colonic Hydrotherapy for Bowel Preparation before Colonoscopy: A Single Center, Randomized, and Controlled Study

    Yan Cao

    2014-01-01

    Full Text Available This single center, randomized, and controlled study aimed to compare the effectiveness and safety of polyethylene glycol electrolyte lavage (PEG-EL solution and colonic hydrotherapy (CHT for bowel preparation before colonoscopy. A total of 196 eligible outpatients scheduled for diagnostic colonoscopy were randomly assigned to the PEG-EL (n=102 or CHT (n=94 groups. Primary outcome measures included colonic cleanliness and adverse effects. Secondary outcome measures were patient satisfaction and preference, colonoscopic findings, ileocecal arrival rate, examiner satisfaction, and cecal intubation time. The results show that PEG-EL group was associated with significantly better colonic cleanliness than CHT group, fewer adverse effects, and increased examiner satisfaction. However, the CHT group had higher patient satisfaction and higher diverticulosis detection rates. Moreover, the results showed the same ileocecal arrival rate and patient preference between the two groups (P>0.05. These findings indicate that PEG-EL is the preferred option in patients who followed the preparation instructions completely.

  2. Short-term and medium-term outcomes of transapical aortic valve implantation as a single-strategy approach: one center's experience

    Čanádyová, Júlia; Mokráček, Aleš; Pešl, Ladislav; KURFIRST, Vojtěch; Šulda, Mirek

    2015-01-01

    Introduction Transcatheter aortic valve replacement has been developed as an alternative option for surgical high-risk or inoperable patients with severe symptomatic aortic stenosis. Aim of the study Aim of the study was to evaluate the outcomes of patients undergoing transapical aortic valve replacement as a single-strategy option by a single-center multidisciplinary heart team. Material and methods Between June 2009 and December 2014, 41 patients underwent transapical transcatheter aortic v...

  3. THE START CAPACITY MANIFESTATION AT THE 10-15 YEARS OLD BOYS DURING THE 50 SM EVENT

    Rată Bogdan Constantin

    2009-06-01

    Full Text Available This study was conducted with the aim of knowing the manifestation of the start capacity, at an agethat represents the beginning of training for the competitive sports, in boys. For this purpose we have recorded,in the 50 sm event, the cumulated time and interval time, on age categories (10-11, 12-13 years old and 14-15years old, out of which we extracted the results for the 5 and 10m. The study was conducted on a group of 81subjects (28 children of 10 and 11 years old, 24 of 12 and 13 and 29 of 14 and 15. As evaluation indicators wehave used, for the anthropometrical profile, the waist and weight, for the manifestation of the start capacity, we used the 50m speed running event, with a standing start in a maximum intensity. The time recording was made every 5 m, with the help of the Brower Timing System, made in Utah, U.S.A. The analysis of the obtained values emphasizes an increase of the start speed, in the first three intervals and in the groups of 10-11 years old,12-13 and 14-15 years old.

  4. PRO-HEALTH BEHAVIOURS AND BELIEF IN ONESELF AMONG 13-15-YEAR OLD TEENAGERS LIVING IN BIALA PODLASKA

    Rafal Grad

    2013-04-01

    Full Text Available The aim of the research was to get information about pro-health behaviours and belief in oneself among 13-15-year old teenagers living in Biała Podlaska. The research included 229 pupils from three Grammar Schools (115 girls and 114 boys. The range of respondents’ age varied from 13 to 15 years old. The research tool was two anonymous questionnaires. The first questionnaire contained questions concerning teenagers’ belief in themselves and the efficacy of their activities (10 statements. The second questionnaire referred to the pro-health behaviours and it consisted of 14 situations described in the form of multiple choice questions. It was shown that Grammar School goers higly evaluated their own sense of efficacy (31,2 points. Girls (30,39 points in comparison to boys (32,05 evaluated their efficacy lower by 1,66 points. Grammar School goers in 85,7% of cases choose healthy behaviours and girls are the group which reach for such behaviours more often.

  5. Pulmonary Functions in Normal School Children in the Age Group of 6-15 Years in North India

    Gurdeep S. Dhooria

    2010-03-01

    Full Text Available Objective:Lung function tests have become an integral part of assessment of pulmonary disease. As few studies on pulmonary function tests have been carried out in young children in India, the study was carried out in normal urban and rural school children in Ludhiana district of North India to determine pulmonary functions in the age group 6-15 years and to find its correlation with regards to age, sex, height and weight. Methods:The study group included 600 normal children between 6-15 years age from different urban and rural schools in the region. A preformed questionnaire was interviewed and detailed general physical and systemic examination was done. Pulmonary function tests were measured by using Micromedical Gold standard fully computerized portable auto spirometer (Superspiro Cat No. SU 6000. Findings:The present study shows, all the three independent variables (age, weight and height have linear positive correlation with lung function parameters, both for boys and girls. Lung function values in boys were significantly higher as compared to that of girls. Urban children had higher lung function parameters than rural children except IRV, FEF25%. Among all anthropometric parameters, height was the most independent variable with maximum coefficient of correlation. Conclusion:Equations derived from the present study for estimation of the expected values of lung function will help to interpret the observed lung function values in children of North India.

  6. Pulmonary Functions in Normal School Children in the Age Group of 6-15 Years in North India

    Sandeep Budhiraja

    2010-03-01

    Full Text Available Objective:Lung function tests have become an integral part of assessment of pulmonary disease. As few studies on pulmonary function tests have been carried out in young children in India, the study was carried out in normal urban and rural school children in Ludhiana district of North India to determine pulmonary functions in the age group 6-15 years and to find its correlation with regards to age, sex, height and weight.Methods:The study group included 600 normal children between 6-15 years age from different urban and rural schools in the region. A preformed questionnaire was interviewed and detailed general physical and systemic examination was done. Pulmonary function tests were measured by using Micromedical Gold standard fully computerized portable auto spirometer (Superspiro Cat No. SU 6000.Findings:The present study shows, all the three independent variables (age, weight and height have linear positive correlation with lung function parameters, both for boys and girls. Lung function values in boys were significantly higher as compared to that of girls. Urban children had higher lung function parameters than rural children except IRV, FEF25%. Among all anthropometric parameters, height was the most independent variable with maximum coefficient of correlation.Conclusion:Equations derived from the present study for estimation of the expected values of lung function will help to interpret the observed lung function values in children of North India.

  7. Endoscopic, transmural drainage and necrosectomy for walled-off pancreatic and peripancreatic necrosis is associated with low mortality--a single-center experience

    Schmidt, Palle Nordblad; Novovic, Srdan; Roug, Stine; Feldager Hansen, Erik

    2015-01-01

    OBJECTIVE: Endoscopic transmural drainage and necrosectomy (ETDN) is a promising alternative to percutaneous drainage and surgical intervention in the treatment of walled-off pancreatic and peripancreatic necroses (WONs). We assessed the outcome and safety profile of ETDN in a single-center patient...

  8. Can gender differences in the educational performance of 15-year old migrant pupils be explained by the gender equality in the countries of origin and destination?

    Dronkers, J.; Kornder, N.

    2013-01-01

    We try to explain the differences between the performance (in both reading and math) of 8430 15-year-old daughters and 8526 15-year-old sons in 17 Organisation for Economic Co-operation and Development destination countries across Europe and Oceania with the PISA 2009 data from 45 origin countries o

  9. Effectiveness of Ministry of Internal Affairs Regulation Number 15 Year 2008 about Mainstreaming Gender on Basic Education Level in the East Java, Indonesia

    Handayani, Trisakti; Widodo, Wahyu

    2016-01-01

    General purpose of this research are: assessing the implementation of Permendagri no. 15 year 2008 about Gender Mainstreaming on Basic Education Levels in the East Java Province, analyze the problem of the implementation of Permendagri no. 15 year 2008 about Gender Mainstreaming on Basic Education Levels in the East Java Province and analyze the…

  10. A single-center study evaluating the effect of the controlled adverse environment (CAEsm model on tear film stability

    Abelson R

    2012-11-01

    Full Text Available Richard Abelson,1,2 Keith J Lane,3 John Rodriguez,3 Patrick Johnston,3 Endri Angjeli,3 George Ousler,3 Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, 2Statistics and Data Corporation, Tempe, AZ; 3Ora, Inc, Andover, MA, USAPurpose: To investigate use of an improved ocular tear film analysis protocol (OPI 2.0 in the Controlled Adverse Environment (CAESM model of dry eye disease, and to examine the utility of new metrics in the identification of subpopulations of dry eye patients.Methods: Thirty-three dry eye subjects completed a single-center, single-visit, pilot CAE study. The primary endpoint was mean break-up area (MBA as assessed by the OPI 2.0 system. Secondary endpoints included corneal fluorescein staining, tear film break-up time, and OPI 2.0 system measurements. Subjects were also asked to rate their ocular discomfort throughout the CAE. Dry eye endpoints were measured at baseline, immediately following a 90-minute CAE exposure, and again 30 minutes after exposure.Results: The post-CAE measurements of MBA showed a statistically significant decrease from the baseline measurements. The decrease was relatively specific to those patients with moderate to severe dry eye, as measured by baseline MBA. Secondary endpoints including palpebral fissure size, corneal staining, and redness, also showed significant changes when pre- and post-CAE measurements were compared. A correlation analysis identified specific associations between MBA, blink rate, and palpebral fissure size. Comparison of MBA responses allowed us to identify subpopulations of subjects who exhibited different compensatory mechanisms in response to CAE challenge. Of note, none of the measures of tear film break-up time showed statistically significant changes or correlations in pre-, versus post-CAE measures.Conclusion: This pilot study confirms that the tear film metric MBA can detect changes in the ocular surface

  11. Quality of life after pertrochanteric femoral fractures treated with a gamma nail: a single center study of 62 patients

    Giessauf Christian

    2012-10-01

    Full Text Available Abstract Background Intramedullary nailing of pertrochanteric femoral fractures has grown in popularity over the past 2 decades likely because this procedure is associated with a low risk for postoperative morbidity and a fast recovery of function. The evaluation of outcomes associated with pertrochanteric nailing has mainly been based on objective measures. The purpose of the present study is to correlate patients’ health-related quality of life results after intramedullary nailing of pertrochanteric fractures with objective outcome measures. Methods We conducted a single-center study including 62 patients (mean age 80 ± 10 years with pertrochanteric fractures treated with a Gamma 3 Nail. Health related quality of life was measured using the Short Form-36. These results were compared to both US and Austrian age and sex-adjusted population norms. The objective outcome measures studied at one year postoperatively included Harris Hip Score, range of motion, leg length, body mass index, neck-shaft angle and grade of osteoarthritis. Results According to the Harris Hip Score 43 patients (67% had excellent or good results. There was no significant difference in the average neck-shaft angle comparing affected hip to non-affected hip at 12 months postoperatively. The average osteoarthritis score, for both the injured and uninjured hip, did not differ significantly. We found significant differences between the bodily pain, social functioning and mental health subscales and two summary scores of the Short-Form 36 in comparison to Austrian population norms. Complication rate was 8%. Conclusions The results of this study confirm that intramedullary nailing with the use of a Gamma Nail is a safe treatment option for stable and unstable pertrochanteric fractures. Despite good functional and radiographic results we noticed a substantial fall off in patients’ quality of life up to 12 months after operation.

  12. Zinc mono-therapy in pre-symptomatic Chinese children with Wilson disease: a single center, retrospective study.

    Kuerbanjiang Abuduxikuer

    Full Text Available BACKGROUND: There is no official consensus regarding zinc therapy in pre-symptomatic children with Wilson Disease (WD; more data is needed. OBJECTIVE: To investigate the safety and efficacy of zinc gluconate therapy for Chinese children with pre-symptomatic WD. METHODS: We retrospectively analyzed pre-symptomatic children receiving zinc gluconate in a single Chinese center specialized in pediatric hepatology. Short-term follow-up data on safety and efficacy were presented, and effects of different zinc dosages were compared. RESULTS: 30 children (21 males aged 2.7 to 16.8 years were followed for up to 4.4 years; 26 (87% children had abnormal ALT at baseline. Most patients (73% received higher than the currently recommended dose of elemental zinc. Zinc gluconate significantly reduced mean ALT (p<0.0001, AST (p<0.0001, GGT (p<0.0001 levels after 1 month, and urinary copper excretion after 6 months (p<0.0054. Mean direct bilirubin levels dropped significantly at 1 month (p = 0.0175, 3 months (p = 0.0010, and 6 months (p = 0.0036. Serum zinc levels gradually increased and reached a significantly higher level after 6 months (p<0.0026, reflecting good compliance with the therapy. Complete blood count parameters did not change throughout the analysis period. 8 children experienced mild and transient gastrointestinal side effects. The higher zinc dose did not affect treatment response and was not associated with different or increased side effects when compared to conventional zinc dose. CONCLUSION: In our cohort, zinc gluconate therapy for Chinese children with pre-symptomatic WD was effective, and higher initial dose of elemental zinc had the same level of efficacy as the conventional dose.

  13. Clinical Results After Prostatic Artery Embolization Using the PErFecTED Technique: A Single-Center Study

    Amouyal, Gregory, E-mail: gregamouyal@hotmail.com; Thiounn, Nicolas, E-mail: nicolas.thiounn@aphp.fr; Pellerin, Olivier, E-mail: olivier.pellerin@aphp.fr [Université Paris Descartes - Sorbonne - Paris - Cité, Faculté de Médecine (France); Yen-Ting, Lin, E-mail: ymerically@gmail.com [Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Interventional Radiology Department (France); Giudice, Costantino Del, E-mail: costantino.delgiudice@aphp.fr [Université Paris Descartes - Sorbonne - Paris - Cité, Faculté de Médecine (France); Dean, Carole, E-mail: carole.dean@aphp.fr [Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Interventional Radiology Department (France); Pereira, Helena, E-mail: helena.pereira@aphp.fr [Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Clinical Research Unit (France); Chatellier, Gilles, E-mail: gilles.chatellier@aphp.fr; Sapoval, Marc, E-mail: marc.sapoval2@aphp.fr [Université Paris Descartes - Sorbonne - Paris - Cité, Faculté de Médecine (France)

    2016-03-15

    BackgroundProstatic artery embolization (PAE) has been performed for a few years, but there is no report on PAE using the PErFecTED technique outside from the team that initiated this approach.ObjectiveThis single-center retrospective open label study reports our experience and clinical results on patients suffering from symptomatic BPH, who underwent PAE aiming at using the PErFecTED technique.Materials and MethodsWe treated 32 consecutive patients, mean age 65 (52–84 years old) between December 2013 and January 2015. Patients were referred for PAE after failure of medical treatment and refusal or contra-indication to surgery. They were treated using the PErFecTED technique, when feasible, with 300–500 µm calibrated microspheres (two-night hospital stay or outpatient procedure). Follow-up was performed at 3, 6, and 12 months.ResultsWe had a 100 % immediate technical success of embolization (68 % of feasibility of the PErFecTED technique) with no immediate complications. After a mean follow-up of 7.7 months, we observed a 78 % rate of clinical success. Mean IPSS decreased from 15.3 to 4.2 (p = .03), mean QoL from 5.4 to 2 (p = .03), mean Qmax increased from 9.2 to 19.2 (p = .25), mean prostatic volume decreased from 91 to 62 (p = .009) mL. There was no retrograde ejaculation and no major complication.ConclusionPAE using the PErFecTED technique is a safe and efficient technique to treat bothersome LUTS related to BPH. It is of interest to note that the PErFecTED technique cannot be performed in some cases for anatomical reasons.

  14. Heterotopic pancreas: a clinicopathological study of 184 cases from a single high-volume medical center in China.

    Zhang, Yifen; Sun, Xitai; Gold, Jason S; Sun, Qi; Lv, Ying; Li, Qiang; Huang, Qin

    2016-09-01

    Heterotopic pancreas (HP) is often an incidental finding during operative or endoscopic procedures and described in case reports and small series in the literature. Large clinicopathological studies with a systematic analysis remain lacking. Herein, we identified 184 (0.18%; 184/99 544) consecutive histology-proven HP cases of 89 770 surgical resections and 9774 upper endoscopic biopsies carried out at a single medical center in China. Each case was diagnosed by unequivocal identification of pancreatic acini at a location outside the pancreas. The patients' median age was 49 years (range, 14-82) with a slight female predominance (male/female ratio, 0.94). Clinical presentation at diagnosis was nonspecific. Preoperatively, most (54.9%; 101/184) HP lesions were misdiagnosed. Only 26 HP lesions (14.1%) were correctly diagnosed, all in the stomach except for 1 in the duodenum; 57 (31%) were detected during operative procedures for other conditions. The most frequent location of HP was, in descending order, the stomach (97; 52.7%), small intestine (48; 26%), lesser and greater curvature omentum (18; 10%), spleen and hilar region (5; 2.7%), porta hepatis (2; 1%), gallbladder (1; 0.5%), peridistal esophageal tissue (4; 2.2%), and mesentery (7; 3.8%). The size of HP varied from smaller than 0.5 cm (35.3%), 0.6 to 1 cm (34.8%), to larger than 1.1 cm (29.9%). Because of difficulty in preoperative diagnosis, careful workup for upper gastrointestinal diseases with HP as a differential diagnosis may increase the chance of accurate diagnosis and appropriate patient management. PMID:27195908

  15. PRIMARY NOCTURNAL ENURESIS IN CHILDREN WITH ALLERGIC RHINITIS AND SEVERE ADENOTONSILLAR HYPERTROPHY: A SINGLE CENTER PILOT STUDY.

    Chimenz, R; Manti, S; Fede, C; Stroscio, G; Visalli, C; Nicotera, A; Di Rosa, G; Romeo, A C; Salpietro, V; Cuppari, C

    2015-01-01

    Nocturnal enuresis is defined as intermittent urinary incontinence during sleep that occurs at least twice a week for three consecutive months. There is no unifying etiology for nocturnal enuresis in the pediatric population and the disorder is likely to be multifactorial. We aimed to investigate the relationship between primary nocturnal enuresis, allergic rhinitis, and related complications in a paediatric case series from a single Center. We retrospectively reviewed and prospectively followed-up at our Institution (i) 32 children (14 females, 18 males; mean age 6.31±1.21 yrs) affected by allergic rhinitis with adenoidal hypertrophygrade I-II (group A) and (ii) 27 children (11 females, 16 males; mean age 6.52±1.33 yrs) affected by allergic rhinitis with adenoidal hypertrophy grade III-IV (group B). Allergic rhinitis was diagnosed on the basis of (a) typical nasal symptoms due to atopic sensitization (e.g., rhinorrhea , itching, sneezing fits, and nasal congestion and obstruction) and (b) positive skin prick testing and/or increased level of total serum IgE. We identified discrepancies between group A and group B in terms of risk of primary nocturnal enuresis. In fact, only 1 child of group A (3.12%) reported uncomplicated primary nocturnal enuresis; conversely, 6 children of group B (22.22%) showed a history of uncomplicated primary nocturnal enuresis (p=0.040). There was no statistically significant difference between the two groups in terms of atopic sensitization and serum total IgE levels (p=0.43). Allergic rhinitis may potentially influence the onset and the natural history of nocturnal enuresis in some children. Children with allergic rhinitis and more severe respiratory manifestations, seem to be more prone to developing primary nocturnal enuresis, likely due to potential multi-factorial causes (e.g., sleep disorders, chronic phlogosis, immune deregulation). PMID:26634591

  16. Implantable cardioverter defibrillator therapy in pediatric and congenital heart disease patients: a single tertiary center experience in Korea

    Bo Kyung Jin

    2013-03-01

    Full Text Available Purpose: The use of implantable cardioverter defibrillators (ICDs to prevent sudden cardiac death is increasing in children and adolescents. This study investigated the use of ICDs in children with congenital heart disease. Methods: This retrospective study was conducted on the clinical characteristics and effectiveness of ICD implantation at the department of pediatrics of a single tertiary center between 2007 and 2011. Results: Fifteen patients underwent ICD implantation. Their mean age at the time of implantation was 14.5±5.4 years (range, 2 to 22 years. The follow-up duration was 28.9±20.4 months. The cause of ICD implantation was cardiac arrest in 7, sustained ventricular tachycardia in 6, and syncope in 2 patients. The underlying disorders were as follows: ionic channelopathy in 6 patients (long QT type 3 in 4, catecholaminergic polymorphic ventricular tachycardia [CPVT] in 1, and J wave syndrome in 1, cardiomyopathy in 5 patients, and postoperative congenital heart disease in 4 patients. ICD coils were implanted in the pericardial space in 2 children (ages 2 and 6 years. Five patients received appropriate ICD shock therapy, and 2 patients received inappropriate shocks due to supraventricular tachycardia.During follow-up, 2 patients required lead dysfunction-related revision. One patient with CPVT suffered from an ICD storm that was resolved using sympathetic denervation surgery. Conclusion: The overall ICD outcome was acceptable in most pediatric patients. Early diagnosis and timely ICD implantation are recommended for preventing sudden death in high-risk children and patients with congenital heart disease.

  17. Presentation, Management, and Outcome of Thyroglossal Duct Cysts in Adult and Pediatric Populations: A 14-Year Single Center Experience

    Hassan Al-Thani

    2016-07-01

    Full Text Available Objectives: A thyroglossal duct cyst (TDC is a frequent congenital midline anomaly of the neck that usually manifests during the first decade of life. We aimed to describe the presentation, management, and outcome of TDC in pediatric and adult cases. Methods: A retrospective observational analysis was conducted for all patients diagnosed and treated for TDC between 2000 and 2014 in a single center in Qatar. Data included patients’ demographics, presentations, preoperative investigations, anesthesia type, histopathological findings, surgical management, recurrences, and complications. Results: We identified 102 patients, of which 57% were males. The mean age of patients was 20.2±15.6 years. A bimodal distribution of TDC has been observed, which peaked between the ages of 6–13 years and at ≥19 years. The preoperative evaluation mainly includes ultrasonography (66%, thyroid function test (44%, and fine-needle aspiration cytology (10%. The median size of the cyst was 25 (2–60 mm. Patients mainly presented with an asymptomatic midline neck mass at or below the hyoid bone (82%, followed by fistula (9%, infection (2%, and dysphagia (2%. Eighty-nine cases were identified preoperatively as TDC. The histopathological findings confirmed TDC with hyoid bone in 61 cases, and TDC alone in 38 cases. Eighty patients underwent the Sistrunk procedure while excision of TDC alone was observed in 18 cases. Five cases of recurrent disease were also treated. Adults had a greater median cyst size (30 (9–60 vs. 22 (2–55 mm; p = 0.005 and required prolonged operation time (69 (1–169 vs. 32.5 (1–140 mins; p = 0.004 compared to the pediatric group. Conclusion: The occurrence of TDC shows a bimodal age distribution. Preoperative evaluation and time for surgery vary whereas clinical presentations, surgical management, and postoperative outcomes are comparable among adult and pediatric groups. Ultrasonography is the preferred diagnostic modality, and the

  18. Single-center open-label randomized study of anemia management improvement in ESRD patients with secondary hyperparathyroidism

    Bellasi Antonio

    2016-04-01

    Full Text Available Whether anemia and mineral bone abnormalities (chronic kidney disease–mineral bone disorder [CKD-MBD] are associated still remains to be elucidated. Both anemia and CKD-MBD have been associated with adverse cardiovascular outcome and poor quality of life. However, recent evidence suggests that use of large doses of erythropoietin-stimulating agents (ESAs to correct hemoglobin (Hb may be detrimental in CKD. The Optimal Anemia Treatment in End Stage Renal Disease (ESRD (Optimal ESRD Treatment study will assess whether lowering of parathyroid hormone (PTH is associated with a reduction in ESA consumption. The Optimal ESRD Treatment study is a pilot single-center open-label study with blinded end point (a prospective randomized open blinded end-point [PROBE] design enrolling 50 patients on maintenance dialysis. Eligible patients with intact PTH (iPTH 300-540 pg/mL and Hb 10-11.5 g/dL will be randomized 1:1 to strict PTH control (150-300 pg/mL versus standard care (PTH range 300-540 pg/mL. Available drugs for CKD-MBD and anemia treatment will be managed by the attending physician to maintain the desired levels of PTH (according to study arm allocation and Hb (10-11.5 g/dL. Echocardiographic data for cardiac structure and function as well as arterial stiffness will be assessed at study inception and completion. The Optimal ESRD Treatment study should shed light on the complicated interplay of anemia and CKD-MBD and on the feasibility of clinical trials in this domain. The study results are expected in the spring of 2017.

  19. Image-guided cryoablation for the treatment of painful musculoskeletal metastatic disease: a single-center experience

    The role of image-guided thermal ablation techniques for the nonoperative local management of painful osseous metastatic disease has expanded during recent years, and several advantages of cryoablation in this setting have emerged. The purpose of this study is to retrospectively evaluate and report a single-center experience of CT-guided percutaneous cryoablation in the setting of painful musculoskeletal metastatic disease. This study was approved by the institutional review board and is compliant with the Health Insurance Portability and Accountability Act. Electronic medical records of all patients who underwent percutaneous image-guided palliative cryoablation at our institution were reviewed (n = 61). An intent-to-treat analysis was performed. Records were reviewed for demographic data and anatomical data, primary tumor type, procedure details, and outcome - including change in analgesic requirements (expressed as morphine equivalent dosages), pain scores (utilizing the clinically implemented visual analog scale), subsequent therapies (including radiation and/or surgery), and complications during the 24 h following the procedure and at 3 months. Patients were excluded (n = 7) if data were not retrospectively identifiable at the defined time points. Fifty-four tumors were ablated in 50 patients. There were statistically significant decreases in the median VAS score and narcotic usage at both 24 h and 3 months (p < 0.000). Six patients (11 %) incurred complications related to their therapy. Two patients had no relief at 24 h, of which both reported worsened pain at 3 months. One patient had initial relief but symptom recurrence at 3 months. Four patients went on to have radiation therapy of the ablation site at some point following the procedure. CT-guided cryoablation is a safe, effective, reproducible procedural option for the nonoperative local treatment of painful musculoskeletal metastatic disease. (orig.)

  20. Clinical Results After Prostatic Artery Embolization Using the PErFecTED Technique: A Single-Center Study

    BackgroundProstatic artery embolization (PAE) has been performed for a few years, but there is no report on PAE using the PErFecTED technique outside from the team that initiated this approach.ObjectiveThis single-center retrospective open label study reports our experience and clinical results on patients suffering from symptomatic BPH, who underwent PAE aiming at using the PErFecTED technique.Materials and MethodsWe treated 32 consecutive patients, mean age 65 (52–84 years old) between December 2013 and January 2015. Patients were referred for PAE after failure of medical treatment and refusal or contra-indication to surgery. They were treated using the PErFecTED technique, when feasible, with 300–500 µm calibrated microspheres (two-night hospital stay or outpatient procedure). Follow-up was performed at 3, 6, and 12 months.ResultsWe had a 100 % immediate technical success of embolization (68 % of feasibility of the PErFecTED technique) with no immediate complications. After a mean follow-up of 7.7 months, we observed a 78 % rate of clinical success. Mean IPSS decreased from 15.3 to 4.2 (p = .03), mean QoL from 5.4 to 2 (p = .03), mean Qmax increased from 9.2 to 19.2 (p = .25), mean prostatic volume decreased from 91 to 62 (p = .009) mL. There was no retrograde ejaculation and no major complication.ConclusionPAE using the PErFecTED technique is a safe and efficient technique to treat bothersome LUTS related to BPH. It is of interest to note that the PErFecTED technique cannot be performed in some cases for anatomical reasons

  1. Image-guided cryoablation for the treatment of painful musculoskeletal metastatic disease: a single-center experience

    Prologo, J.D. [Emory University Hospital, Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image-Guided Medicine, Atlanta, GA (United States); Passalacqua, Matthew; Patel, Indravadan; Bohnert, Nathan [University Hospitals Case Medical Center, Department of Radiology, Cleveland, OH (United States); Corn, David J. [University Hospitals Case Medical Center, Departments of Radiology and Biomedical Engineering, Cleveland, OH (United States)

    2014-11-15

    The role of image-guided thermal ablation techniques for the nonoperative local management of painful osseous metastatic disease has expanded during recent years, and several advantages of cryoablation in this setting have emerged. The purpose of this study is to retrospectively evaluate and report a single-center experience of CT-guided percutaneous cryoablation in the setting of painful musculoskeletal metastatic disease. This study was approved by the institutional review board and is compliant with the Health Insurance Portability and Accountability Act. Electronic medical records of all patients who underwent percutaneous image-guided palliative cryoablation at our institution were reviewed (n = 61). An intent-to-treat analysis was performed. Records were reviewed for demographic data and anatomical data, primary tumor type, procedure details, and outcome - including change in analgesic requirements (expressed as morphine equivalent dosages), pain scores (utilizing the clinically implemented visual analog scale), subsequent therapies (including radiation and/or surgery), and complications during the 24 h following the procedure and at 3 months. Patients were excluded (n = 7) if data were not retrospectively identifiable at the defined time points. Fifty-four tumors were ablated in 50 patients. There were statistically significant decreases in the median VAS score and narcotic usage at both 24 h and 3 months (p < 0.000). Six patients (11 %) incurred complications related to their therapy. Two patients had no relief at 24 h, of which both reported worsened pain at 3 months. One patient had initial relief but symptom recurrence at 3 months. Four patients went on to have radiation therapy of the ablation site at some point following the procedure. CT-guided cryoablation is a safe, effective, reproducible procedural option for the nonoperative local treatment of painful musculoskeletal metastatic disease. (orig.)

  2. Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants

    Calafat, Antonia M.; Marcus, Michele; Jaakkola, Jouni J.K.; Lashen, Hany

    2015-01-01

    Background Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator–activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations. Objectives We explored associations of total testosterone and sex hormone–binding globulin (SHBG) concentrations at age 15 years with prenatal exposures to PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS), and perfluoronanoic acid (PFNA) in females. Methods Prenatal concentrations of the perfluoroalkyl acids (PFAAs) were measured in serum collected from pregnant mothers at enrollment (1991–1992) in the Avon Longitudinal Study of Parents and Children (ALSPAC). The median gestational age when the maternal blood sample was obtained was 16 weeks (interquartile range, 11–28 weeks). Total testosterone and SHBG concentrations were measured in serum obtained from their daughters at 15 years of age. Associations between prenatal PFAAs concentrations and reproductive outcomes were estimated using linear regression models (n = 72). Results Adjusted total testosterone concentrations were on average 0.18-nmol/L (95% CI: 0.01, 0.35) higher in daughters with prenatal PFOS in the upper concentration tertile compared with daughters with prenatal PFOS in the lower tertile. Adjusted total testosterone concentrations were also higher in daughters with prenatal concentrations of PFOA (β = 0.24; 95% CI: 0.05, 0.43) and PFHxS (β = 0.18; 95% CI: 0.00, 0.35) in the upper tertile compared with daughters with concentrations in the lower tertile. We did not find evidence of associations between PFNA and total testosterone or between any of the PFAAs and SHBG. Conclusions Our findings were based on a small study sample and should be interpreted with caution. However, they suggest that prenatal

  3. The X-ray outburst of the Galactic Centre magnetar SGR 1745-2900 during the first 1.5 year

    Coti Zelati, F.; Rea, N.

    2016-06-01

    At a projected separation of 0.1 pc from the supermassive black hole at the Center of the Milky Way, Sgr A*, the transient magnetar SGR J1745-2900 holds the record as the closest neutron star to a black hole ever observed. SGR J1745-2900 has been the object of an intensive monitoring campaign in the X-rays for about 1.5 years since the outburst onset, from April 2013 until September 2014. Detailed analysis of the data has revealed an extremely slow flux decay compared to the other known transient magnetars, making this source rather unique. The extremely slow cooling is currently challenging the state-of-the art neutron star crustal cooling models. If the outburst evolution is indeed due to crustal cooling, as predicted and observed for all other magnetar outbursts in the past 10 years, then magnetic energy injection needs to be continuous over at least the first ˜200 days, something so far never observed for sources of the class. Alternatively, heating of the star surface may result from strong magnetospheric currents confined within a gradually shrinking magnetic bundle which impact upon the surface. However detailed numerical simulations are needed to confirm this possibility.

  4. Prevalence and sociodemographic correlates of stunting, underweight, and overweight among Palestinian school adolescents (13-15 years in two major governorates in the West Bank

    Awartani Faisal

    2009-12-01

    Full Text Available Abstract Background There is little information about height and weight status of Palestinian adolescents. The objective of this paper was to assess the prevalence of stunting, underweight, and overweight/obesity among Palestinian school adolescents (13-15 years and associated sociodemographic factors in 2 major governorates in the West Bank. Methods A Cross-sectional survey was conducted in 2005 comprising 1942 students in 65 schools in Ramallah and Hebron governorates. Data was collected through self-administered questionnaires from students and parents. Weights and heights were measured. Overweight and obesity were assessed using the 2000 Centers for Disease Control and Prevention (CDC reference and the International Obesity Task Force (IOTF criteria. Stunting and underweight were assessed using the 2000 CDC reference. Results Overweight/obesity was more prevalent in Ramallah than in Hebron and affected more girls than boys. Using the 2000 CDC reference, the prevalence of overweight and obesity in Ramallah among boys was 9.6% and 8.2%, respectively versus 15.6% and 6.0% among girls (P Conclusion Under- and overnutrition co-exist among Palestinian adolescents, with differences between sexes. Region, residence, STL, and onset of puberty were associated factors.

  5. Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15-year-old with a large submental mass.

    Seow-En, Isaac; Loh, Amos Hong Pheng; Lian, Derrick Wen Quan; Nah, Shireen Anne

    2015-01-01

    A 15-year old boy presented with a 2-year history of a painless slowly enlarging submental neck mass. Head and neck imaging showed a multicystic mass with a central solid component that was closely applied to the hyoid bone. Core needle biopsy under general anaesthesia revealed a papillary thyroid neoplasm. The mass was resected and frozen section histology confirmed papillary carcinoma. Intraoperatively, enlarged cervical lymph nodes were palpable. Bilateral neck dissections and total thyroidectomy with parathyroid reimplantation were performed. On histological examination, the thyroid gland was not involved. The patient recovered uneventfully from the surgery and is planned for radioactive iodine therapy and thyroxine suppression, with subsequent follow-up with serum thyroid-stimulating hormone and thyroglobulin for surveillance. We review the literature and discuss challenges in the diagnosis and surgical management of this rare entity in the paediatric age group. PMID:26150648

  6. Examining the Effects of Long Term Exercise Training on Some Physical and Physiological Parameters of 12 - 15 Years Old Children

    Yeliz ÖZVEREN

    2014-08-01

    Full Text Available The aim of this study is to make a determination about the case, by searching physical and physiological parameters with Eurofit tests of boy students at İzmir. The research was made on the age group of 12 - 15 years old, volunteer 1002 boy students who are studying at primary schools; those were chosen randomly in Karabağlar, Konak and Buca boroughs in İzmir. Height and weight, body fat percentage, vertical bounce, 20 m. shuttle run test test, max VO2, grip strength, leg strength, back strength, FVC and FEV1 tests were applied to these students. In conclusion, there were significant differences between test group and control group.

  7. Stable isotope analysis of a newly established macrofaunal food web 1.5 years after the Hebei Spirit oil spill.

    Han, Eunah; Park, Hyun Je; Bergamino, Leandro; Choi, Kwang-Sik; Choy, Eun Jung; Yu, Ok Hwan; Lee, Tae Won; Park, Heung-Sik; Shim, Won Joon; Kang, Chang-Keun

    2015-01-15

    We examined trophic relationships in a newly established community 1.5 years after the Hebei Spirit oil spill on the west coast of Korea. Carbon and nitrogen stable isotope ratios in consumers and their potential food sources were compared between the oil-spill site and reference site, located 13.5 km from the oil-spill spot. The isotopic mixing model and a novel circular statistics rejected the influx of petrogenic carbon into the community and identified spatial consistencies such as the high contributions of microphytobenthos, food-chain length, and the isotopic niche of each feeding guild between sites. We suggested that high level of trophic plasticity and the prevalence of omnivory of consumers may promote the robustness of food web against the oil contamination. Furthermore, we highlighted the need of holistic approaches including different functional groups to quantify changes in the food web structure and assess the influence of different perturbations including oil spill. PMID:25467873

  8. Screening for psychopathology in a national cohort of 8- to 15-year-old children with cerebral palsy

    Rackauskaite, Gija; Bilenberg, Niels; Bech, Bodil Hammer;

    2015-01-01

    Cerebral palsy (CP) is often accompanied by psychopathology and learning disability. AIMS: (1) to evaluate the prevalence of psychopathology as estimated by the Child Behavior Checklist (CBCL) parental questionnaire in 8- to 15-year-old Danish children with CP and to analyze its association...... the CBCL. The cutoff for psychopathology was the Total CBCL score or DSM-oriented scores above the 93rd percentile in an age- and gender-stratified population. RESULTS: The psychopathology screening was positive in 46.2% (CI 41.6-50.8%) against 15.1% in general population. Cognitive disability...... for psychopathology should be a part of multidisciplinary follow-up of CP. The CBCL can be used as a screening instrument in children with CP without severe motor and cognitive disability....

  9. Variability in lateralised blood flow response to language is associated with language development in children aged 1-5 years.

    Kohler, M; Keage, H A D; Spooner, R; Flitton, A; Hofmann, J; Churches, O F; Elliott, S; Badcock, N A

    2015-01-01

    The developmental trajectory of language lateralisation over the preschool years is unclear. We explored the relationship between lateralisation of cerebral blood flow velocity response to object naming and cognitive performance in children aged 1-5 years. Functional transcranial Doppler ultrasound was used to record blood flow velocity bilaterally from middle cerebral arteries during a naming task in 58 children (59% male). At group level, the Lateralisation Index (LI) revealed a greater relative increase in cerebral blood flow velocity within the left as compared to right middle cerebral artery. After controlling for maternal IQ, left-lateralised children displayed lower expressive language scores compared to right- and bi-lateralised children, and reduced variability in LI. Supporting this, greater variability in lateralised response, rather than mean response, was indicative of greater expressive language ability. Findings suggest that a delayed establishment of language specialisation is associated with better language ability in the preschool years. PMID:25950747

  10. Multimodal physiotherapeutic management for stage-IV osteitis pubis in a 15-year old soccer athlete: a case report.

    Vijayakumar, P; Nagarajan, M; Ramli, Ayiesah

    2012-01-01

    Osteitis pubis among soccer athletes is a disabling painful condition and it is difficult to manage without integrating a multimodal treatment approach. There is limited scientific evidence on the effectiveness of exercise in treating Osteitis pubis especially when it progress to a chronic painful condition. The purpose of this case report is to discuss the successful multimodal physiotherapeutic management for a 15-year old soccer athlete diagnosed with stage-IV Osteitis pubis. Land and water based active core muscle strengthening exercises, Proprioceptive neuromuscular facilitation techniques (PNF) and Manual Therapy are some of the essential components incorporated in multimodal intervention approach with emphasis to water based strength and endurance training exercises. The athlete was able to make progress to a successful recovery from his chronic painful condition and accomplished the clearly established clinical outcomes during each phase of rehabilitation. PMID:23220803

  11. [A case of allergic granulomatosis and angiitis (Churg-Strauss syndrome) in a 15-year-old girl].

    Fujita, Kazue; Yamato, Kenji; Kurihara, Takeyuki; Osaki, Kohichi; Ohba, Hideo; Nakamura, Junichi; Okimoto, Niro

    2004-09-01

    A 15-year-old girl with a 6-month history of bronchial asthma was admitted to our hospital because of fever, dyspnea, weight loss, dysesthesia, muscle weakness, gait disturbance and purpuric rash. In addition, leukocytosis, hypereosinophilia and elevation of CRP were observed. Chest radiograph and computed tomography on admission showed non-segmental patchy air-space consolidation in both lung fields. Skin biopsy was performed and the pathologic diagnosis was necrotizing arteritis with eosinophilic infiltration. Transbronchial lung biopsy revealed eosinophilic pneumonia. From the clinical course, laboratory data and pathologic findings, the diagnosis of allergic granulomatosis and angiitis (Churg-Strauss syndrome) was made. Following the skin and lung biopsies, intravenous pulse corticosteroid and oral prednisolone treatment was started and her clinical findings improved. Angiitis with allergic granulomatosis is a vasculitis that is found in adults. This is an extremely rare and interesting case of angiitis with allergic granulomatosis in childhood. PMID:15500154

  12. The integration of visual context information in facial emotion recognition in 5- to 15-year-olds.

    Theurel, Anne; Witt, Arnaud; Malsert, Jennifer; Lejeune, Fleur; Fiorentini, Chiara; Barisnikov, Koviljka; Gentaz, Edouard

    2016-10-01

    The current study investigated the role of congruent visual context information in the recognition of facial emotional expression in 190 participants from 5 to 15years of age. Children performed a matching task that presented pictures with different facial emotional expressions (anger, disgust, happiness, fear, and sadness) in two conditions: with and without a visual context. The results showed that emotions presented with visual context information were recognized more accurately than those presented in the absence of visual context. The context effect remained steady with age but varied according to the emotion presented and the gender of participants. The findings demonstrated for the first time that children from the age of 5years are able to integrate facial expression and visual context information, and this integration improves facial emotion recognition. PMID:27367301

  13. Assessment of Dental Maturity of Children Aged 7-15 Years Using Demirjian Method in a Selected Iranian Population

    Abesi F.

    2013-12-01

    Full Text Available Statement of Problems: Dental age can be estimated on the basis of the tooth mineralization level during the developmental process of the teeth. Among various radiological methods reported for the dental age determination in children, Demirjian method is widely used. Purpose: To evaluate the applicability of Demirjian method in age estimation of the children aged 7-15 years in Babol, a northern city of Iran.Materials and Method: A cross sectional study was performed on the panoramic radiographs of 168 individuals with 7-15 years old. Maturation of the seven permanent teeth on the left side of the mandible was determined according to the crown and root development stages; described by Demirjian method. The mean of the dental age (DA according to the Demirjian was compared to the mean of chronological age (CA. Data were collected and analyzed using SPSS, V18. P-values<0.05 were considered significance.Results: The mean and the SD of CA was 11.06±2.29 (boys: 11.08±2.31, girls: 11.03±2.28. The mean and the SD of DA was 11.44±2.85 (boys: 11.81±2.93, girls: 11.08±2.73 and the mean and the SD of DA minus CA for all of the children were 0.38±1.24 (boys: 0.72±1.2, girls: 0.05±1.21. Also, t-Test analysis showed the differ-ences of the mean value of the estimated - chronological age difference was statistically significant between the boys and the girls group (p< 0.001.Conclusion: Considering the determined differences between estimated dental age and chronological age in this study; Demirjian method can be applicable for estimation of dental age in girls and boys before their puberty in northern of Iran.

  14. Impact of Hearing Loss on Daily Life Style and Schooling among Children between 5 and 15 Years Age-Group

    Hiteshree C Patel, Mohua Moitra, Anjali Modi, Jaymin Contractor, S L Kantharia

    2014-01-01

    Full Text Available Background: “Hearing”- one of the five special senses with which a human is gifted. At times, due to variety of reasons, this sense is impaired. Hearing impairment of any degree has a profound effect on children. It delays development of speech, slows educational progress and leads to being stigmatized. Objectives: To document the impact of hearing loss in daily life style and schooling of children between 5 and 15 years age-group. Materials & methods: This was cross- sectional study done in Children between 5 and 15 years age-group with hearing loss, coming to an ENT OPD, New Civil Hospital, Surat during the period of 1st August 2011 to 31 July 2012. Results: A total of 246 children were studied. Mean age of the study population was 9±3.46 years. Most common impactin life of children with hearing loss was that “they were not admitted to school by their parents” (31.3%. Among them, 84.4% had congenital deafness and 15.6% had acquired deafness. This difference was statistically significant. (p= 0.002, x2= 8.63. As per parents’ perception, academic performance of the children was significantly associated with type of school (normal Vs deaf & mute school” (p< 0.001. Conclusion: Most common impact was that “children being not admitted to school” and “children were lagging behind in studies”. Among the congenitally deaf children, the quality of life was significantly better in those who attended these special schools (p<0.001.

  15. Oral cleanliness of 12-13-year-old and 15-year-old school children of Sunsari District, Nepal

    Yee R

    2006-09-01

    Full Text Available The aim of the study was to evaluate the oral cleanliness of school children in the District of Sunsari, Nepal. A multi-stage random sampling oral epidemiological survey was conducted in private and government, urban, rural town and rural village schools in 15 illakas of Sunsari District, Eastern Nepal. A total of 600, 12-13-year-old and 600 15-year-old school children were examined by trained examiners using the simplified oral hygiene index (OHI-S. The average age-group, debris and calculus index scores were combined to obtain the simplified oral hygiene index (OHI-S. The mean OHI-S scores were compared and evaluated using the parametric t-test for two independent samples. The mean OHI-S for urban 12-13-year-old school children was 0.98 compared to 1.34 for school children of rural towns and 1.44 for school children of rural villages and these differences in mean OHI-S were statistically significant ( P < 0.005. In the 15-year-old age group, urban school children had a mean OHI-S score of 1.00 compared to 1.37 for rural towns and 1.43 for rural villages. The variance in the mean OHI-S scores were statistically significant ( P < 0.005. The overall level of cleanliness in the school children surveyed was good. Children of urban schools had the lowest scores followed by school children from rural towns and then rural villages. When the mean OHI-S scores were compared with the DMFT scores, there was an inverse relationship between oral cleanliness and dental caries. Frequency of sugar consumption and the availability and affordability of fluoridated toothpaste may be important factors in the development of dental caries than oral cleanliness.

  16. The stability of life satisfaction in a 15-year follow-up of adult Finns healthy at baseline

    Honkanen Risto J

    2005-01-01

    Full Text Available Abstract Background While physical health has improved considerably over recent decades in Finland, the disease burden of mental health, especially that of depression, has become increasingly demanding. However, we lack long-term data on the natural course of subjective well-being in the general population. The aim of this study was to investigate the long-term course of self-reported life satisfaction. Methods This was a 15-year prospective cohort study on a nationwide sample of adult Finnish twins (N = 9679, aged 18–45 and healthy at baseline, who responded to postal questionnaires in 1975, 1981 and 1990 including a 4-item life satisfaction scale (happiness/easiness/interest in life and feelings of loneliness. Life satisfaction score (range: 4–20 was classified into three categories: satisfied (4–6, intermediate (7–11 and dissatisfied group (12–20. The associations between life satisfaction scores during the follow-up were studied with linear/logistic regression. Results Moderate stability and only a slight effect of age or birth-cohort on mean life satisfaction score (LS were detected. In 1990, 56% of all and 31% of the dissatisfied remained in the same LS category as at baseline. Only 5.9% of the study subjects changed from being satisfied to dissatisfied or vice versa. Correlations between continuous scores (1975, 1981 and 1990 were 0.3–0.4. Baseline dissatisfaction (compared to satisfaction predicted dissatisfaction in 1981 (OR = 10.4; 95%CI 8.3–13.1 and 1990 (5.6; 4.6–6.8. Multiple adjustments decreased the risk only slightly. Conclusions Life satisfaction in adult Finns was moderately stable during 15 years. Among an identifiable group (i.e. the dissatisfied life dissatisfaction may become persistent, which places them at a greater risk of adverse health outcomes.

  17. Atherosclerotic Renal Artery Stenosis Prevalence and Correlations in Acute Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Interventions: Data From Nonrandomized Single‐Center Study (REN‐ACS)—A Single Center, Prospective, Observational Study

    Burlacu, Alexandru; SIRIOPOL, Dimitrie; VORONEANU, Luminita; Nistor, Ionut; Hogas, Simona; Nicolae, Ana; Nedelciuc, Igor; TINICA, Grigore; Covic, Adrian

    2015-01-01

    Background We are the first to evaluate the prevalence of renal artery stenosis (RAS) in consecutive patients with acute myocardial infarction (AMI) referred for primary percutaneous coronary intervention from a single tertiary center. As a novelty, we assessed hydration and metabolic status and measured arterial stiffness. We elaborated a predicting model for RAS in AMI. Methods and Results One hundred and eighty‐one patients with AMI underwent concomitantly primary percutaneous coronary int...

  18. Haematological manifestations and frequency of fab subtypes in patients of acute myeloid leukaemia: a single center study

    To determine the clinical/haematological manifestations and frequency of different subtypes of Acute Myeloid Leukaemia (AML) according to the French-American-British (FAB) classification. Study Design: Descriptive study. Place and Duration of Study: The study was carried out at haematology department of Armed Forces Institute of Pathology (AFIP), Rawalpindi from January 2011 to September 2012. Material and Methods: Retrospective review of documents of patient diagnosed to have acute myeloid leukaemia on bone marrow aspiration was done. Patient's age, gender, major signs and symptoms at time of presentation and haematological parameters of peripheral blood and bone marrow were noted. The subtype of AML according to FAB classification was also documented. Data was entered and analyzed in SPSS 16.0. Results: During the selected study duration acute myeloid leukaemia was diagnosed in 173 patients on bone marrow examination. Out of these 123 (71.1%) were males and 50 (28.9%) were females. Thirty (17.3%) of the patients fell in paediatric age group (< 15 years) while the remaining 143 (82.7%) were in adult age category (> 15 years). The mean age of presentation was 9 years among paediatric patients and 44.5 years among adults. The overall mean age of both these two groups was 38.4 years (3-84 years). Fever (71.6%), generalized weakness (34.1%) and pallor (23.7%) were the three main complaints of the patients, followed by splenomegaly and lymphadenopathy. The mean total leukocyte count, haemoglobin and platelet count were 57.4 * 109/L, 7.9 g/dL and 54 * 109/L respectively. AML-M2 was found to be the most frequent FAB AML subtype among 72 (41.6%) paediatric and adult patients. Conclusion: The main signs and symptoms of the patients of AML presenting to our centre were fever, generalized weakness and pallor. AML-M2 was found to be the most common FAB subtype among AML in children and adults. (author)

  19. STUDY OF RISK FACTORS AND LABORATORY PROFILE IN UNDER 15 YEARS AGE GROUP CHILDREN WITH ACUTE RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE

    Ramu

    2015-03-01

    Full Text Available CONTEXT : BACKGROUND : Acute Rheumatic fever / Rheumatic Heart disease is the most common acquired child hood heart disease diagnosis made in India and is consistently associated with poverty and overcrowding. There is no single symptom , sign or laboratory test that is diagnostic of Acute Rheumatic fever and carditis . Revised , edited and updated Jones criteria are guidelines to assist practitioners and are not a substitute for clinical judgment . The main concern in liberalizing these criteria in developed countries may be over diagnosis of Acute Rheumatic fever. AIMS & OBJECTIVES: To study the risk factors and laboratory profile in children with Acute Rheumatic fever / Rheumatic Heart d isease. MATERIALS & METHODS: The Study was conducted for 2 years period in a tertiary care hospital on less than 15 years children diagnosed as Acute Rheumatic fever / Rheumatic Heart disease. RESULTS: In our study all the cases (100% , 36 cases belongs to Lower socio economic status. Overcrowding is noted in all 36 cases (100% and we noticed rural predilection in 91.7% (33 cases cases. CONCLUSION: Basing on the results of our study we conclude that lower socio economic status , overcrowding (100% cases a nd rural predilection (91.7% are frequent associate risk factors of Acute Rheumatic fever / Rheumatic Heart disease. Further we found Anemia (88.89% , positive C.R.P (86.11% , and A.S.O titer more than 400 I.U/ml in (69.44% as common laboratory abnormali ties.

  20. The thin and medium filters of the EPIC camera on-board XMM-Newton: measured performance after more than 15 years of operation

    Barbera, Marco; Gastaldello, Fabio; Sciortino, Luisa; Agnello, Simonpietro; Buscarino, Gianpiero; Collura, Alfonso; La Palombara, Nicola; Cicero, Ugo Lo; Sartore, Nicola; Tiengo, Andrea; Varisco, Salvatore; Venezia, Anna Maria

    2016-08-01

    After more than 15 years of operation of the EPIC camera on board the XMM-Newton X-ray observatory, we have reviewed the status of its Thin and Medium filters. We have selected a set of Thin and Medium back-up filters among those still available in the EPIC consortium and have started a program to investigate their status by different laboratory measurements including: UV/VIS transmission, Raman scattering, X-Ray Photoelectron Spectroscopy, and Atomic Force Microscopy. Furthermore, we have investigated the status of the EPIC flight filters by performing an analysis of the optical loading in the PN offset maps to gauge variations in the optical and UV transmission. We both investigated repeated observations of single optically bright targets and performed a statistical analysis of the extent of loading versus visual magnitude at different epochs. We report the results of the measurements conducted up to now. Most notably, we find no evidence for change in the UV/VIS transmission of the back-up filters in ground tests spanning a 2 year period and we find no evidence for change in the optical transmission of the thin filter of the EPIC-pn camera from 2002 to 2012. We point out some lessons learned for the development and calibration programs of filters for X-ray detectors in future Astronomy missions.

  1. Erectile Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Outcomes from a Multi-Center Study and Risk Factor Analysis in a Single Center

    Chen, Xin; Wang, Zhu; Chen, Shengfu; Yang, Qiyun; Wan, Zi; Han, Dayu; Xiao, Haipeng; Sun, Xiangzhou; Deng, Chunhua

    2016-01-01

    The aim of this study was to investigate the prevalence of erectile dysfunction (ED) in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and explore the influence of UPOINT domains, National Institutes of Health-CP symptom index (NIH-CPSI) and other factors on ED prevalence. This was a prospective study of consecutive patients with CP/CPPS seen at 11 tertiary hospitals during January–July 2014. ED was diagnosed as a score ofclinical examination, asocio-demographic questionnaire, the Patient Health Questionnaire (PHQ), the Pain Catastrophizing Scale (PCS), NIH-CPSI and IIEF-5.1406 patients from 11 centers (mean age, 32.18 years; range 18–60 years) were enrolled. ED was found in 638/1406 patients (45.4%), and was categorized as mild in 291(45.6%), moderate in 297(46.6%) and severe in50(7.7%). 192 patients from one center(mean age,31.3 years; range 18–57 years) were further studied.IIEF-5 score correlated negatively with NIH-CPSI(r = 0.251), PHQ (r = 0.355) and PCS (r = 0.322)scores (P<0.001).PHQ score correlated positively with NIH-CPSI (r = 0.586) and PCS(r = 0.662) scores (P<0.001).NIH-CPSI, PHQ, PCS and IIEF-5 scores did not differ significantly between class IIIA and IIIB CP/CPPS. Multivariate logistic regression showed that UPOINT psychological (P) domain and NIH-CPSI symptom severity were independent risk factors for ED in CP/CPPS. It is concluded that psychological factors and symptom severity are independent risk factors for ED in CP/CPPS. PMID:27120096

  2. Ankle sprain injuries in soccer players aged 7-15 years during a one-year season

    NIKOLAOS KOFOTOLIS

    2014-10-01

    Full Text Available Although ankle sprains are common in soccer, the role of various risk factors in soccer players aged 7-15 is unclear. The purpose of this study was to examine whether incidence of ankle sprain injuries, associated time loss of participation, and injury risk factors are associated with chronological age in soccer players aged 7-15 years. A sample of 677 male soccer players was divided in three age groups: between 7 and 9 years (U9, between 9 and 12 years (U12 and between 12 and 15 years (U15. Ankle sprain injury incidence, participation time loss, injury mechanisms, ankle region injured, and other risk factors were recorded in games and practice sessions using questionnaires for one year. During the study 38 ankle injuries were recorded, of which 27 were ankle sprains. These led to 182.7 sessions lost (on average, 6.71 lost sessions per injury. There was an increased risk of ankle injury in U15 group compared with U12 (relative risk = 2.34; 95% confidence interval, 1.28 to 5.02 while no injuries for the U9 were observed. Most incidents (66.7% were contact injuries with the highest injury risk displayed by goalkeepers. Injury rate was higher in games than in practice and increased in the second half of the match (p< .05. Multinomial logistic regression showed that history of previous injury was a significant predictor of ankle sprain in the U15 group (relative risk = 1.69; 95% confidence interval, 1.0 to 2.9. Age is an important factor for soccer training because many clubs use chronological age to separate their young players into teams. This study showed that children less than 9 years showed no injury risk while players older than 12 years showed a higher risk. Injury rate was, however, lower than that reported previously for adult players. Injury prevention strategies may be particularly useful for young adolescent soccer players

  3. Evaluation Efficacy of Ferrous Sulfate Therapy on Headaches of 5-15 Years Old Iron Deficient Children with Migraine

    Fallah, R; Zare Bidoki, S; Ordooei, M

    2016-01-01

    Background Some researches have shown the association between iron deficiency and migraine headache in adults. The aim of present study was to evaluate efficacy of ferrous sulfate treatment on migraine headaches of 5-15 years old migraineur children with iron deficiency. Materials and Methods In a quasi- experimental study, monthly frequency, severity, duration and disability of headaches of 5-15 years old migraineur children that prophylactic therapy was indicated in them and had iron deficiency who were referred to Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran between 2013 and 2015 and were treated with 2mg/kg/day topiramate plus 4mg/kg/day of ferrous sulfate for three consecutive months, were evaluated and headache characteristics before and after treatment were compared. Results In this study, 98 children with mean age of 9.72±3.19 were evaluated that 31children (31.6%) had iron deficiency. Monthly frequency (22.89±7.18 vs.14.5±4.56, P= 0.02), severity score (8.12± 1.76 vs. 5.03±1.15, P= 0.02) and disability score of headache (38.23±10.7vs. 30.12±7.46, P= 0.03) were more in children with iron deficiency. Iron therapy was effective in decreasing of monthlyfrequency 22.89± 7.18 vs. 10.13±4.51, P = 0.001), severity score (8.12±1.76 vs. 5.11±1.62, P =0.001), duration (2.14±1.23 vs.1.14±1.01, P= 0.001) and disability score of headache (38.23±10.7 vs. 22.87±8.65, P= 0.01). Conclusion In children, iron deficiency increased monthly frequency, severity and disability of migraine headache and ferrous sulfate can be used as a safe and effective drug in migraine prophylaxis.

  4. PRIMARY PREVENTION OF MYOCARDIAL INFARCTION IN MIDDLE-AGED MALES (15-YEAR FOLLOW-UP: CLINICAL AND ECONOMIC ASPECTS OF THE PROBLEM

    A. M. Kalinina

    2015-09-01

    Full Text Available Aim. To estimate incidence rate of first myocardial infarction (MI with different outcomes and factors, it is influenced by, depending on the intensity of preventive measures in a population of middle-aged men during 15-year follow-up; to evaluate economic efficiency of primary medical prevention.Material and methods. Two populations of middle-aged men with a total of 6656 males (3488 men the group of active prevention and 3168 the group of comparison were followed up over 15 years.Results. The group of active prevention revealed 22.1% reduced MI incidence rate during 5-year follow-up as compared to the second group, fatal MI incidence rate was 42.4% lower, p<0.05. Mortality rate in new cases of MI was 35.8% in the group of active prevention and 48.5% at routine treatment (p<0.05. The group of active prevention continued to have 17.9% reduced MI incidence rate during the 10-year follow-up as compared to the group of routine management (p>0.05, while patients with clinical signs of ischemic heart disease (IHD and no history of previous MI kept significant distinctions in first MI incidence rate (41% less in the first group, p<0.05. First MI incidence for the 10-year period was the least at risk factors (RF absence and twice higher even at single RF presence. Combination of RF caused 4-5 fold increase in risk for MI. Life status of 81.3% of the enrolled men (5410 of 6656 followed over 15 years was received along with the monitoring of prognosis.Such indices as “life years saved” (LYS and “quality-adjusted life years saved” (QALYS for 1000 persons in the active prevention group were 53 and 51 years, respectively during the 5-year follow-up, 147 and 143 years – during the 10-year follow-up. In the long-term actual expenses for 1 LYS were 3.4-fold less than annual gross domestic product (GDP value, at that charges for primary prevention – 4-fold less, which has been for the first time demonstrated using factual data and not mathematic

  5. Paramagnetic centers in single-walled carbon nanotubes encapsulated with palladium and their interaction with hydrogen at H/C ≥ 1.0

    Lipson, A. G.; Saunin, E. I.; Lyakhov, B. F.; Tsivadze, A. Yu.

    2008-10-01

    The nature of paramagnetic centers in a nanostructure based on single-walled carbon nanotubes (SWCNTs) encapsulated with Pd was studied by EPR spectroscopy at 77 and 293 K. It was found that strong charge-transfer π complexes of the (Pd-C x ) type, which manifested themselves as a narrow resonance (Δ H = 6 8 G and g = 2.002 at T = 77 k), were formed in the Pd-SWCNT composite along with impurity centers (Fe3O4 nanoparticles within the nanotubes), which were responsible for a broad EPR signal (Δ H = 75 G and g = 2.065 at T = 293 K). These complexes were found to be predominant adsorption sites responsible for a high gravimetric density of hydrogen (H/C ≥ 1.0) within the single-walled carbon nanotubes.

  6. Efficacy of stereotactic gamma knife surgery and microvascular decompression in the treatment of primary trigeminal neuralgia: a retrospective study of 220 cases from a single center

    Dai, Zi-Feng; Huang,Qilin; Liu, Haipeng; Zhang, Wei

    2016-01-01

    Zi-Feng Dai, Qi-Lin Huang, Hai-Peng Liu, Wei Zhang Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing, People’s Republic of China Objectives: A retrospective study was undertaken to compare the efficacy of stereotactic gamma knife surgery (GKS) and microvascular decompression (MVD) in the treatment of primary trigeminal neuralgia (TN) at a single center. The study included the evaluation of clinical outcomes of p...

  7. Fixation method does not affect restoration of rotation center in hip replacements: A single-site retrospective study

    Wegner Alexander

    2012-06-01

    Full Text Available Abstract Background Aseptic loosening is one of the greatest problems in hip replacement surgery. The rotation center of the hip is believed to influence the longevity of fixation. The aim of this study was to compare the influence of cemented and cementless cup fixation techniques on the position of the center of rotation because cemented cup fixation requires the removal of more bone for solid fixation than the cementless technique. Methods We retrospectively compared pre- and post-operative positions of the hip rotation center in 25 and 68 patients who underwent artificial hip replacements in our department in 2007 using cemented or cementless cup fixation, respectively, with digital radiographic image analysis. Results The mean horizontal and vertical distances between the rotation center and the acetabular teardrop were compared in radiographic images taken pre- and post-operatively. The mean horizontal difference was −2.63 mm (range: -11.00 mm to 10.46 mm, standard deviation 4.23 mm for patients who underwent cementless fixation, and −2.84 mm (range: -10.87 to 5.30 mm, standard deviation 4.59 mm for patients who underwent cemented fixation. The mean vertical difference was 0.60 mm (range: -20.15 mm to 10.00 mm, standard deviation 3.93 mm and 0.41 mm (range: -9.26 mm to 6.54 mm, standard deviation 3.58 mm for the cementless and cemented fixation groups, respectively. The two fixation techniques had no significant difference on the position of the hip rotation center in the 93 patients in this study. Conclusions The hip rotation center was similarly restored using either the cemented or cementless fixation techniques in this patient cohort, indicating that the fixation technique itself does not interfere with the position of the center of rotation. To completely answer this question further studies with more patients are needed.

  8. Percutaneous renal artery stenting reduces arterial blood pressure, but what about renal function? A single-center experience

    Erkan Dervişoğlu

    2010-02-01

    Full Text Available Objective: To assess the effects of percutaneous transluminal angioplasty and stenting (PTRA/S on arterial blood pressure and renal function.Methods: A retrospective chart review of patients undergoing PTRA/S at our institution between December 2003 and September 2006 was done. Follow-up data were derived from hospital records. Estimated glomerular filtration rate (EGFR was used as the marker of renal function. To evaluate the pre- and post-procedure values in individual patients the paired t test and Wilcoxon signed-rank tests were used.Results: Thirty-six patients (16 women, 30 men; mean age 59±15 years, range: 25-83 years underwent 43 PTRA/S interventions at our institution. The mean duration of follow-up was 9.3±8.6 (range 2-28 months. We observed no significant change in EGFR from pre-procedure to that obtained at follow-up (71.4±40.2 mL/min vs.73.3±39.0 mL/min; p=0.483. Mean arterial blood pressure (MABP, however, was reduced significantly: pre-procedure MABP-123±22 mmHg; post-procedure follow-up value of 101±14 mmHg (p <0.001. The mean number of antihypertensive medications used at the time of intervention was 2.1±1.0 (range: 0-4, whereas at follow-up, this number had decreased to 1.3±1.0 (range: 0-4; p<0.001. In patients with renal impairment (EGFR ≤59 mL/min, 41% showed improvement, 29% showed no change and 29% demonstrated deterioration in EGFR. Conclusion: PTRA/S may preserve renal function, especially in patients with pre-procedural impaired renal function.

  9. Increased Incidence of Early Onset Colorectal Cancer in Arizona: A Comprehensive 15-year Analysis of the Arizona Cancer Registry

    Aziz, Hassan; Pandit, Viraj; DiGiovanni, Ryan M.; Ohlson, Eric; Gruessner, Angelika C.; Jandova, Jana; Nfonsam, Valentine N.

    2016-01-01

    Introduction The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry. Methods We performed a retrospective analysis of patients with colorectal cancer reported in the Arizona Cancer Registry from 1995-2010. Outcome measure: incidence of CRC in patients younger than 50 years. Results 39,623 cases of colorectal cancer were reported to the Arizona Cancer Registry during a period of 15 years. Overall, there was a 17% decrease in the incidence of CRC. However, there was a 23% increase in incidence among patients in the age group 10-50. During the same time period, 15% and 41% increase in the incidence of colon and rectal cancer was observed, respectively. The most significant increase (102%) in overall CRC incidence was seen in the age group 10-29. The highest increase (110%) in incidence of colon cancer was observed in the same age group, while the most significant increase in incidence rates (225%) of rectal cancer was seen in the age group 30-34. Conclusion Although there is an overall decrease in incidence of colorectal cancer in Arizona, alarming increase in incidence of early-onset CRC was observed; mirroring the national trends.

  10. Stable isotope analysis of a newly established macrofaunal food web 1.5 years after the Hebei Spirit oil spill

    Highlights: • We examined trophic structure in a newly established community after an oil spill. • This is the most extensive in situ isotopic analysis on an oiled benthic community. • Consumer-food source δ13C and δ15N rejected influx of petroleum into the community. • A novel circular statistics rejected trophic niche change of major feeding guilds. • Prevalence of omnivory and trophic plasticity may promote the recovery process. - Abstract: We examined trophic relationships in a newly established community 1.5 years after the Hebei Spirit oil spill on the west coast of Korea. Carbon and nitrogen stable isotope ratios in consumers and their potential food sources were compared between the oil-spill site and reference site, located 13.5 km from the oil-spill spot. The isotopic mixing model and a novel circular statistics rejected the influx of petrogenic carbon into the community and identified spatial consistencies such as the high contributions of microphytobenthos, food-chain length, and the isotopic niche of each feeding guild between sites. We suggested that high level of trophic plasticity and the prevalence of omnivory of consumers may promote the robustness of food web against the oil contamination. Furthermore, we highlighted the need of holistic approaches including different functional groups to quantify changes in the food web structure and assess the influence of different perturbations including oil spill

  11. Scoliosis screening results of primary school students (11–15 years old group) in the west side of Istanbul

    Çolak, Tuğba Kuru; Apti, Adnan; Dereli, E.Elçin; Özdinçler, Arzu Razak; Çolak, İlker

    2015-01-01

    [Purpose] The present study aimed to find out the scoliosis prevalence 11–15 years old children and to create awareness about scoliosis. [Subjects and Methods] All of the children were assessed using the Adams Forward Bendings Test and a scoliometer. Sagittal plane changes such as kyphosis, lordosis, hypokyphosis, hypolordosis and anterior head tilt were screened. Children with trunk rotation angles (ATR) of 4 degrees or more were suspected of having scoliosis, and were evaluated for a second time for gibbosity height, arm-trunk distance, and ATR. [Results] A total of 2,207 children were screened and the evaluation revealed there were 11 girls (0.49%) with a Cobb angle of 10 degrees and more. The maximum Cobb angle was 43° (right thoracic-left lumbar) and the maximum ATR was 12°. Two children had kyphosis and lordosis, and one had hypokyphosis and was diagnosed as having idiopathic scoliosis. [Conclusion] Families should regularly check their children, even if they are not diagnosed as having scoliosis in school screenings. It is our opinion that our study increased the awareness of the families about scoliosis by screening, brochures and posters. In the future, if school screenings were performed as a routine procedure and scoliotic students were followed over the long term, the actual effectiveness of screening would be able to be detected. PMID:26504296

  12. Lessons learnt from the 15 years experience of the French case in the field of HLLL waste

    Year 2006 has been marked in France by the vote in the Parliament of the Planning Act of 28 June, 2006, concerning the sustainable management of radioactive materials and waste. This vote was the achievement of a 15 years research programme performed as required by the previous Research Law of 1991, also known as the Bataille Law, from the name of Christian Bataille, MP, who drafted it and monitored its enforcement as a member of the Parliamentary Office for Scientific and Technological Assessment (Office Parlementaire d'Evaluation des Choix Scientifiques et Techniques - OPECST). At that time a stepwise approach to siting was introduced in the process. It included the study of several alternatives to the geological disposal of long lived high level radioactive waste. Those alternatives have been thoroughly studied and assessed before the Government decided to submit the bill to the Parliament. Experience has been gained not only on the scientific and technical aspects, but also in the field of decision making process, also called now governance. However, not only the results of the research programme were decisive in preparing the bill, but also of major importance were the industrial experience of ANDRA and the rigorous programme management along all those years. Main lessons learnt from the experience are given in this paper. (authors)

  13. Dairy Consumption and the Risk of 15-Year Cardiovascular Disease Mortality in a Cohort of Older Australians

    Timothy P. Gill

    2013-02-01

    Full Text Available The effects of habitual dairy consumption and the risk of 15-year cardiovascular disease (CVD mortality in a cohort of older Australians were investigated. Participants (n = 2900 completed a validated 145-item semi-quantitative food frequency questionnaire. Cox proportional hazards regression models were used to investigate associations between tertiles of the dairy consumption, including low/reduced fat dairy, whole fat dairy and their ratio (ratioLF/WF, and risk of mortality from coronary heart disease (CHD, stroke or combined CVD. There were 548 recorded cases of CVD mortality in this cohort. For total dairy intake, a reduction in risk of CVD was only seen in tertile 2 (adjusted hazard ratio, AHR: 0.71; 95% CI: 0.55–0.93, and for CHD both tertile 2 and tertile 3 were associated with a reduced risk (both with AHR: 0.71. However there were no linear trends between total dairy consumption and any of the three outcomes. There were no associations or trends between low/reduced fat dairy or whole fat dairy consumption, or ratioLF/WF and any of the three outcomes in the fully adjusted model (all p > 0.05. This study found no consistent association between baseline consumption of dairy foods and the risk of CHD, stroke and combined CVD mortality.

  14. Reinforcement of Portuguese transmission network capacity to receive new renewable power production. Portuguese experience from last 15 years

    Rodriguez, Tiago; Batista, Fernando; Pitarma, Antonio [Rede Electrica Nacional (REN), S.A., Lisboa (Portugal). Planning Dept.

    2012-07-01

    From last 10/15 years to now Portuguese government decided to promote the renewable energies in order to increase the total amount of electric energy produced from renewable sources and reduce the quantity of fossil energy that has been imported every year. To achieve this goal the number of new renewable power plants has increased a lot, mainly through wind farms that have grown from almost 0 in 2000 to 4300 MW nowadays. According to Portugal's geography, the locations showing higher wind potential are generally situated on inner regions with low values of load demand and where the existent electric transmission network wasn't designed/prepared to accommodate those amounts of new generation. So there was the need of reinforcing the transmission network capacity and structures. As there were too many requests (almost 500 for a total of 7600 MW in 2002) from promoters to connect new power plants, it was also necessary to develop a new methodology to evaluate network nodal reception capacities and to manage it, without jeopardizing the security of network operation. (orig.)

  15. X-ray Sources in the Magellanic Clouds: analysis of 15 Years of XMM-Newton and Chandra Observations

    Yang, J.; Laycock, S.; Christodoulou, D.; Drake, J.; Fingerman, S.; Hong, J.; Zezas, A.; Antoniou, V.; Coe, M.; Ho, W.

    2016-06-01

    Using ˜160 XMM-Newton, ˜180 Chandra, and all weekly RXTE observations, we have generated a comprehensive library of the known pulsars in the Small and Large Magellanic Clouds (SMC, LMC). We classify various pulsar properties in the range of log L_{X}=32-38 erg s^{-1} and incorporate related parameters in theoretical models. With the high time-resolution data of the EPIC and Chandra cameras and the latest calibration files and software, our 15 year pipeline generates a suite of useful products for each pulsar detection: event lists, high time-resolution light curves, periodograms, spectra, and complete histories of the dot{P}, the pulse fraction, etc., in the broad, soft (0.2-2 keV), and hard (2-12 keV) energy bands. After combining the observations from these telescopes, we found that 15 pulsars are clearly spinning up and another 15 pulsars are distinctly spinning down. We also used the faintest and brightest sources to map out the propeller line and the Eddington line, respectively. We compared the observed pulse profiles to geometric models of X-ray emission in order to constrain the physical parameters of the pulsars. We are preparing a public release of this library so that it can be used by other groups as well.

  16. Blindness and Frequency of Vitrectomy in Young Danish Type 1 Diabetic Patients. A 15-year follow-up

    Broe, Rebecca; Olsen, Birthe Susanne; Grauslund, Jakob; Hougaard, Philip; Sjølie, Anne Katrin

    patients who had undergone vitrectomy and the date of their first surgery. Results were correlated to age, gender, diabetes duration and HbA1c. Results: Of the 324 patients examined in 1995, 6 have been registered as blind (4 males and 2 females), 5 were between 21 and 29 years old at registration. They...... had all had vitrectomy performed and mean HbA1c in 1995 was 10.8 ± 1.3%. Thirty seven patients (11%) have undergone vitrectomy. At the time of their first surgery the mean age of patiens was 29.5 ± 4.9 years and the mean duration of DM was 22.7 ± 4.9 years. The rate of male patients were significantly.......8 %, p<0.05). Conclusions: One in ten patients had undergone vitrectomy in a 15-year follow-up of a population-based cohort of Danish type 1 diabetic patients. The mean age at the time of surgery was less than 30 years. Our results indicate that high levels of HbA1c in childhood and adolescence, as well...

  17. Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report

    Shrestha P

    2013-08-01

    Full Text Available Pratyush Shrestha,1 Nabin K Shrestha,2 Smith Giri31Department of Surgery, College of Medical Sciences, Bharatpur, Nepal; 2Department of Internal Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal; 3Department of Internal Medicine, Tribhuvan University Teaching Hospital, Kathmandu, NepalIntroduction: Fulminant meningococcemia is a relatively rare life-threatening disease caused by Neisseria meningitidis. The clinical presentation is varied, but, when associated with myocarditis, it carries a particularly poor prognosis. We report a case of a patient with fulminant meningococcemia who subsequently developed severe myocardial dysfunction and successfully recovered within a period of 14 days of hospitalization.Case presentation: A 15-year-old girl presented with headache, fever, body ache, and diarrhea for 1 day, and ecchymotic rash over her body for 4 hours. Blood cultures confirmed infection with N. meningitidis. After 6 days in the hospital, the patient developed anasarca, elevated jugular venous pressure, and shock. The patient was managed with intravenous ceftriaxone and captopril. Over the next 3 days the patient rapidly improved and started walking.Conclusion: Meningococcemia complicated by myocarditis has an extremely poor prognosis with high mortality. Our case suggests that recovery from a severe myocardial dysfunction can occur rapidly within a few days. Prompt recognition and management in this case might have contributed to the patient's rapid recovery from myocarditis.Keywords: Neisseria meningitidis, Nepal, recovery, shock

  18. Review of 15 years: high-density low-enriched UMo dispersion fuel development for research reactors in Europe

    Berghe, S. van den [SCK.CEN, Nuclear Materials Science Institute (NMS), Boeretan (Belgium); Lemoine, P [Commissariat a l' Eergie Atomique, CEA Saclay, Yvette Cedex (France)

    2014-04-15

    This review aims to provide a synthesis of the knowledge generated and the lessons learned in roughly 15 years of UMo dispersion fuel R and D in Europe through a series of irradiation experiments. A lot of irradiations were also performed outside of Europe, particularly in the USA, Russia, Canada, Korea and Argentina. In addition, a large number of out-of-pile investigations were done throughout the world, providing support to the understanding of the phenomena governing the UMo behaviour in pile. However, the focus of this article will be on the irradiations and Post-Irradiation Examination (PIE) results obtained in European experiments. The introduction of the article provides a historic overview of the evolution and progress in the high density UMo dispersion fuel development. The ensuing sections then provide further details on the various phases of the development, from the UMo dispersion in a pure Al matrix through the addition of Si to the matrix to address the interaction layer formation and finally to the more advanced solutions to the excessive swelling encountered in various experiments. This review was based only on published results or results that are currently in the process of being published.

  19. The heritability of psychopathic personality in 14- to 15-year-old twins: a multirater, multimeasure approach.

    Tuvblad, Catherine; Bezdjian, Serena; Raine, Adrian; Baker, Laura A

    2014-09-01

    Until now, no study has examined the genetic and environmental influences on psychopathic personality across different raters and method of assessment. Participants were part of a community sample of male and female twins born between 1990 and 1995. The Child Psychopathy Scale and the Antisocial Process Screening Device were administered to the twins and their parents when the twins were 14-15 years old. The Psychopathy Checklist: Youth Version (PCL:YV) was administered and scored by trained testers. Results showed that a 1-factor common pathway model was the best fit for the data. Genetic influences explained 69% of the variance in the latent psychopathic personality factor, while nonshared environmental influences explained 31%. Measurement-specific genetic effects accounted for between 9% and 35% of the total variance in each of the measures, except for PCL:YV, where all genetic influences were in common with the other measures. Measure-specific nonshared environmental influences were found for all measures, explaining between 17% and 56% of the variance. These findings provide further evidence of the heritability in psychopathic personality among adolescents, although these effects vary across the ways in which these traits are measured, in terms of both informant and instrument used. PMID:24796343

  20. 15 years of production of electric energy of the Laguna Verde power plant, its plans and future

    In the year 2005 Laguna Verde power plant reaches 15 years of producing electric power in Mexico arriving to but of 100 million Megawatts-hour from their beginning of commercial activities. The Unit 1 that entered at July 29, 1990 and the Unit 2 at April 10, 1995, obtaining the Disposability Factors from their origin is: 84.63% in Unit 1 and 83.67% in Unit 2. The march of the X XI century gives big challenges of competition to the Laguna Verde Central, with the possible opening of the electric market to private investment, for their Goals and Objectives of a world class company, taking the evaluation system and qualification of the World Association of Nuclear Operators (WANO) that promotes the Excellence in the operation of the nuclear power stations in all their partners. This Association supports the development of programs that allow the monitoring of the behavior in Safety Culture, Human fulfilment, Equipment reliability, Industrial Safety, Planning, Programming and Control, Personalized Systematic Training, and the use of the Operational experience in the daily tasks. The present work tries to explain the system of evaluation/qualification of WANO, the definition of Goals and Objectives to reach the excellence and of the programs, it will present the Program of the Reliability of Equipment with its main actions the productivity. (Author)

  1. A 15 year record of high-frequency, in situ measurements of hydrogen at Mace Head, Ireland

    A. Grant

    2010-02-01

    Full Text Available Continuous high-frequency measurements of atmospheric molecular hydrogen have been made at Mace Head atmospheric research station on the west coast of Ireland from March 1994 to December 2008. The presented data provides information on long term trends and seasonal cycles of hydrogen in background northern hemispheric air. Individual measurements have been sorted using a Lagrangian dispersion model to separate clean background air from regionally polluted European air masses and those transported from southerly latitudes. No significant trend was observed in background northern hemispheric air over the 15 year record, elevations in yearly means were accounted for from large scale biomass burning events. Seasonal cycles show the expected pattern with maxima in spring and minima in late autumn. The mean hydrogen mole fraction in baseline northern hemispheric air was found to be 500.1 ppb. Air transported from southerly latitudes showed an elevation from baseline mean of 11.0 ppb, reflecting both the latitudinal gradient of hydrogen, with higher concentrations in the Southern Hemisphere, and the photochemical source of hydrogen from low northern latitudes. European polluted air masses arriving at Mace Head showed mean elevation of 5.3 ppb from baseline air masses, reflecting hydrogen's source from primary emissions like fossil fuel combustion. Forward modelling of transport of hydrogen to Mace Head suggests that the ratio of hydrogen to carbon monoxide in primary emissions is considerably less in non-traffic sources than traffic sources.

  2. DAILY PHYSICAL ACTIVITY AND PHYSICAL FITNESS IN 11-TO 15-YEAR-OLD TRAINED AND UNTRAINED TURKISH BOYS

    Alpay Güvenç

    2011-09-01

    Full Text Available The aims of this study were to assess levels and patterns of physical activity (PA in relation to age and regular sport activity, and to examine its relationship to physical fitness in trained and untrained boys. One hundred forty-seven 11-to 15- year-old boys (73 trained and 74 untrained participated in this study. Trained boys, comprised of 26 soccer, 25 handball and 22 volleyball players, had been training regularly for at least one year. The intensity, duration and frequency of PA were assessed from four complete days of heart rate monitoring with 15-seconds sampling intervals. Aerobic fitness was assessed by determining peakVO2 with a portable breath-by-breath gas analyzer (Cosmed K4b2 and the running speeds at fixed lactate concentrations during an incremental running test. Anaerobic fitness was evalu-ated with the Wingate Anaerobic Test. Skinfold thicknesses from eight sites and Tanner stages of pubic hair were also obtained. Based on 15-s heart rate data, instead of continuous activity, multiple short bouts of moderate and vigorous PA, lasting up to one minute, were characteristic of daily PA patterns of both trained and untrained boys. PA levels of trained boys were higher than untrained boys (p 0.05. No relationship was observed between PA variables and anaerobic fitness in either group (p> 0.05. It seems that such relationships may somewhat depend on the fitness level of the subjects

  3. Gingival proliferative lesions in children and adolescents in Brazil: A 15-year-period cross-sectional study

    Fabiana Caroline daSilva

    2016-01-01

    Full Text Available Background: Studies assessing the prevalence of oral lesions in children and adolescents, particularly in gingiva are scarce in the literature. The aim of the study was to describe the distribution of gingival proliferative lesions based on clinical and histopathological diagnoses in children and adolescents. Materials and Methods: A review of clinical charts of children and adolescents aged between 0 and 18 years old, admitted to the Oral Medicine Outpatient Unit, of Universidade Federal do Paraná, for 15 years (1994–2009 was performed. Results: Six hundred and sixty-nine out of 5,129 patients treated during this period were aged between 0 and 18 years old, and 45 of these had gingival lesions. The largest number of lesions was observed between 11 and 16 years old. The majority of the patients were referred by Curitiba's public health system. Pyogenic granuloma was the most frequent lesion (19 = 42.2%, followed by peripheral giant cell lesion (11 = 24.4%, gingival fibromatosis (10 = 22.2%, and peripheral ossifying fibroma (5 = 11.1%. Conclusion: Gingival proliferative lesions can show similar clinical characteristics. Appropriate clinical and histopathological diagnoses are necessary to guide the healthcare professional to establish the adequate treatment and to estimate the risk of recurrence.

  4. Dental plaque, caries prevalence and gingival conditions of 14-15-year-old schoolchildren in Jerash District, Jordan.

    El-Qaderi, S S; Quteish Ta'ani, D

    2006-08-01

    The aim of this cross-sectional study was to evaluate oral hygiene, gingival condition and dental caries prevalence in 14-15-year-old school children in Jerash District, Northern Jordan. Twenty schools (10 male and 10 female schools) with 1362 children of eighth and ninth grades were randomly selected and incorporated in this study. All participants had dental examinations for oral hygiene, gingival condition and dental caries experience using the Silness and Löe Plaque Index (PI), Löe and Silness Gingival Index (GI), and decayed (D), missing (M) and filled (F) teeth (DMFT) and surface (DMFS) codes respectively. The results showed that males had significant lower plaque but significantly higher gingival scores than females (P < 0.001). About 24% of children were caries-free. The proportions of children with one, two or three decayed teeth were between 10% and 18%. Slight non-significant variations between males and females were observed in regard to DMFT/S and their components (P < 0.05). It is concluded that significant gender variations were noted in PI and GI scores but not in DMFT/S or their components. However, the values of these clinical scores were lower than those results previously reported in northern Jordan. PMID:16958744

  5. Dental implants three-dimensional position affected by late facial bone growth: follow-up of 12 to 15 years

    Judith Ottoni

    2011-10-01

    Full Text Available Background: The three-dimensional (3D position of the osseointegrated dental implants provides favorable esthetical results and preserves the surrounding soft and hard tissues architecture in a long term analysis. However, recent studies demonstrate that the continued growth at adult life can also be noticed on the craniofacial skeleton. Therefore, considerable change may occur interfering on the relationship between a fix structure, the implant, and the adjacent teeth, with the possibility of forward and downward movement, due to the craniofacial growth. The question is: how long the harmonic relationship, previously established between the crown supported implant and natural teeth, is going to maintain esthetically pleasant? This article is based on three cases of adult patients with ages varying from 38 to 60 years old, when implants were inserted, and afterwards these patients were followed up during 12 to 15 years. It has been concluded that the continued craniofacial growth can lead to an infraocclusion of the implants–supported crown and to diasthem, which may negatively impact on both the aesthetics and the chewing quality.

  6. Overview of the MISSE 7 Polymers and Zenith Polymers Experiments After 1.5 Years of Space Exposure

    Yi, Grace T.; deGroh, Kim, K.; Banks, Bruce A.; Haloua, Athena; Imka, Emily C.; Mitchell, Gianna G.

    2013-01-01

    As part of the Materials International Space Station Experiment 7 (MISSE 7), two experiments called the Polymers Experiment and the Zenith Polymers Experiment were flown on the exterior of the International Space Station (ISS) and exposed to the low Earth orbit (LEO) space environment for 1.5 years. The Polymers Experiment contained 47 samples, which were flown in a ram or wake flight orientation. The objectives of the Polymers Experiment were to determine the LEO atomic oxygen erosion yield (Ey, volume loss per incident oxygen atoms, given in cu cm/atom) of the polymers, and to determine if atomic oxygen erosion of high and low ash containing polymers is dependent on fluence. The Zenith Polymers Experiment was flown in a zenith flight orientation. The primary objective of the Zenith Polymers Experiment was to determine the effect of solar exposure on the erosion of fluoropolymers. Kapton H (DuPont, Wilmington, DE) was flown in each experiment for atomic oxygen fluence determination. This paper provides an introduction to both the MISSE 7 Polymers Experiment and the MISSE 7 Zenith Polymers Experiment, and provides initial erosion yield results.

  7. Comparison of anxiety levels associated with noise in the dental clinic among children of age group 6-15 years

    Radhika Muppa

    2013-01-01

    Full Text Available Fear or anxiety due to noise produced in the dental clinic is rated third among the reasons to avoid dental visits. The aim of the present study was to determine anxiety levels associated with noise in a dental clinic. The study was done using a survey questionnaire containing 10 questions and was divided into two parts. The first part included demographic information such as name, age, gender, and school; the second half included questions regarding patient′s feelings toward noise in the dental clinic and its possible link to dental anxiety. Two-hundred and fifty children and adolescents of age group 6-15 years participated in the study. Results of the study showed that 50% of females, 29% males avoided a visit to the dentist because of anxiety and fear, 38% subjects of age group 6-11 years reported that sound of the drill makes them uncomfortable, followed by having to wait in the reception area. Gender gap was also observed with more females feeling annoyed than males on the 1-10 annoyance level scale. More than 60% felt "annoyed" to "extremely annoyed" by noise in the dental clinic. 45% of subjects preferred watching television to cope with such noise. This study concludes that the noise produced in dental clinic is anxiety provoking and significantly contributes to avoidance of dental treatment and the best way opted by the majority of subjects to overcome this anxiety was audiovisual distraction method.

  8. Orofacial granulomatosis affecting lip and gingiva in a 15-year-old patient: A rare case report

    Monika Bansal

    2015-01-01

    Full Text Available Orofacial granulomatosis (OFG is a rare disorder affecting the orofacial region, and clinically characterized by diffuse, nontender, soft to firm, painless swelling restricted to one or both lips and intraoral sites such as tongue, gingiva and buccal mucosa. Histologically, OFG is characterized by noncaseating granulomatous inflammation. The early diagnosis of OFG is essential for the better prognosis of the lesion. Delay in diagnosis of OFG results into formation of indurated and permanent swelling of the lip that not only compromises esthetic appearance but also causes impairment in function such as speaking and eating. Early diagnosis of OFG is challenging to the health care professionals due to clinical and histological resemblance to other chronic granulomatous disorders. Thus, dentists may act as a first person to diagnose the lesion and play an important role in the multidisciplinary treatment of granulomatous disorders. Here, we present a case of OFG affecting lips and gingiva in a 15-year-old patient without any identifiable systemic or local causes.

  9. The characteristics of head wounds inflicted by "humane killer" (captive-bolt gun)--a 15-year study.

    Simic, Milan; Draskovic, Dragan; Stojiljkovic, Goran; Vukovic, Radenko; Budimlija, Zoran M

    2007-09-01

    The "humane killer" or captive-bolt gun, is the tool/weapon widely used in meat industry and private farmer households for slaughtering animal stock. Out of 17,250 autopsies performed at the Institute of Forensic Medicine in Novi Sad during the 15-year period (1991-2005), 29 cases of suicides and two homicides were committed by captive-bolt pistols. Wounds inflicted by captive-bolt guns have specific morphological features, distinctive from wounds made by other kinds of hand firearms. Selected features of the captive-bolt wounds (punched round entrance and a double pattern of smoke soiling) depend on distance and angle of instrument at the time of firing. Autopsy findings were compared with an experimental model consisting of 20 domestic pigs. Obtained results confirmed that the appearance of the entrance hole and soot deposits, along with differences in shape, location, extent, and density of soot blackening, could be useful in identification of weapon, direction of discharge, shooting distance, and angle of the muzzle to the frontal and sagittal planes of the head at the moment of fire. PMID:17767661

  10. Dynamics of the indicators of physical development, physical and technical fitness of young 12 - 15 year old weightlifters of the different groups of weight categories

    Lutovinov Iu.A.; Oleshko V.G.; Lisenko V.N.; Tkachenko K.V.

    2012-01-01

    Here is the dynamics of indicators of physical development, physical and technical preparedness of young 12 - 15 year old weightlifters who are training for the Championship of Ukraine. 50 sportsman's has taken part in investigation. Age of sportsman - 12 - 15 years old. The indicators of physical development and preparedness of sportsmen were researched. The indicators of physical preparedness in control snatch, clean and jerk exercises were analyzed. The interconnection among the indicators...

  11. Maternal Factors Associated with Nutritional Status of 1-5 years Children Residing in Field Practice Area of Rural Health Training Centre Naila, Jaipur (Rajasthan) India

    Lokesh Sonkaria, Afifa Zafer, Kusum Lata Gaur, Ravindra Kumar Manohar

    2014-01-01

    Background: Good nutrition bene-fits families, their communities and the world as a whole. Maternal factors are important in maintaining the nutrition of 1-5 year children. Objective: To ascertain the association of maternal factors with nutrition of 1-5 year children. Materials and Methods: A community based cross sectional descriptive type of observational study was carried out in the field practice area of RHTC Naila in Jaipur district of Rajasthan. 30 Cluster sampling technique was ...

  12. A Logistic Regression Analysis of Turkey's 15-Year-Olds' Scoring above the OECD Average on the PISA'09 Reading Assessment

    Kasapoglu, Koray

    2014-01-01

    This study aims to investigate which factors are associated with Turkey's 15-year-olds' scoring above the OECD average (493) on the PISA'09 reading assessment. Collected from a total of 4,996 15-year-old students from Turkey, data were analyzed by logistic regression analysis in order to model the data of students who were split…

  13. Can gender differences in the educational performance of 15-year old migrant pupils be explained by the gender equality in the countries of origin and destination?

    Dronkers, J; Kornder, N.

    2013-01-01

    We try to explain the differences between the performance (in both reading and math) of 8430 15-year-old daughters and 8526 15-year-old sons in 17 Organisation for Economic Cooperation and Development destination countries across Europe and Oceania with the PISA 2009 data from 45 origin countries or regions. In addition to the level of societal gender equality of the origin and destination countries (the gender empowerment measure, or GEM) we use macro indicators of the educational systems, e...

  14. Epidemiologic characteristics of oral cancer:single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center

    Ji Zhang; Ming Song; Fan Gao; AnKui Yang; WenKuan Chen; ShuWei Chen; Huan Li; Xing Zhang; ZhongYuan Yang; XinLin Chen

    2016-01-01

    Background: Oral cancer is a common type of head and neck cancers. Knowing its epidemiologic characteristics is crucial to preventing, diagnosing, and treating this cancer. This study aimed to explore the epidemiologic characteris‑tics of oral cancer in South China. Methods: We retrospectively analyzed data from 4097 oral cancer patients treated at the Sun Yat‑sen University Cancer Center between 1960 and 2013. We compared the age of onset, sex ratio, pathologic type, and primary tumor location among three subcultural areas (Guangfu, Hakka, and Chaoshan) and between an economically developed region and a less‑developed one in Guangdong. Results: Overall, oral cancer had a male‑to‑female ratio of approximately 2:1, and this ratio decreased over time. Oral cancer occurred mostly in patients of 45–64 years old (54.5%), and the percentage of older patients gradually increased over time. The most common tumor location was the tongue. Squamous cell carcinoma was the predomi‑nant pathologic type. The percentage of blood type O in oral cancer patients was lower than that in the healthy pop‑ulation. The male‑to‑female ratio in the Chaoshan area was higher than that in the Guangfu and Hakka areas, whereas the age of disease onset in Guangfu was higher than that in Hakka and Chaoshan. The male‑to‑female ratio was lower and the age of disease onset was higher in the economically developed region than in the less‑developed region. Conclusion: The incidence of oral cancer in South China presents typical characteristics to which doctors should pay attention when diagnosing and treating oral cancer patients.

  15. 15 years of research in the biomedical effects of electromagnetic fields at the electropathological research center of Witten/Herdecke University - an interim statement

    Reissenweber, J.H.; Wojtysiak, A.; David, E. [Zentrum fuer Elektropathologie, Universitaet Witten/Herdecke (Germany)

    2004-07-01

    Among other issues the phenomenon of self-reported electromagnetic hypersensitivity is still a problem in modern industrial societies discussed in context with electromagnetic fields. When persons suffer from uneasiness or dizziness which they subjectively attribute to the hypothetical health effects of weak electromagnetic fields they will need professional help by specialized physicians. This medical help can be provided at ERC. Here electromagnetically hypersensitive persons are taken seriously and their individual situation and subjective burden of suffering are analyzed and categorized. They can participate in a specialized new diagnostic program which will be demonstrated in detail and is carried out by a medical specialist. Beyond further research programs this program will be continued as well as the research into cell membrane reactions under field influence. (orig.)

  16. Performance of Multiple Risk Assessment Tools to Predict Mortality for Adult Respiratory Distress Syndrome with Extracorporeal Membrane Oxygenation Therapy: An External Validation Study Based on Chinese Single-center Data

    Lei Huang

    2016-01-01

    Conclusions: The RESP, APCHAE II, and SOFA scorings systems show good predictive value for intra-hospital survival of ARDS patients treated with ECMO in our single-center evaluation. Future validation should include a larger study with either more patients' data at single-center or by integration of domestic multi-center data. Development of a scoring system with national characteristics might be warranted.

  17. Radiation-damage-induced defects in quartz. I. Single-crystal W-band EPR study of hole centers in an electron-irradiated quartz

    Nilges, Mark J.; Pan, Yuanming; Mashkovtsev, Rudolf I.

    2008-03-01

    Single-crystal W-band electron paramagnetic resonance (EPR) spectra of an electron-irradiated quartz, measured at room temperature, 110 and 77 K, disclose three previously reported hole centers (#1, G and an ozonide radical). The W-band EPR spectra of these three centers clearly resolve six magnetically nonequivalent sites each, whereas previous X- and Q-band EPR studies reported Centers #1 and the ozonide radical to consist of only three symmetry-related components and interpreted them to reside on twofold symmetry axes in the quartz structure. The calculated g matrices of Center #1 and the ozonide radical show that deviations from twofold symmetry axes are <10°, which are probably attributable to distortion related to neighboring charge compensating ions. The W-band EPR spectra of Center G not only result in improved g matrices but also allow quantitative determination of the nuclear hyperfine ( A) and quadrupole ( P) matrices of its 27Al hyperfine structure that was incompletely resolved before. In particular, the g-maximum and g-minimum principal axes of Center G are approximately along two pairs of O-O edges of the SiO4 tetrahedron, while the unique A principal axis is approximately along a Si-Si direction. These new spin-Hamiltonian parameters suggest that Center G most likely involves trapping of a hole between two oxygen atoms related to a silicon vacancy and stabilized by an Al3+ ion in the neighboring tetrahedron (hence an O{2/n-}-Al3+ defect, where n is either 1 or 3).

  18. Higher Rates of Retinopathy of Prematurity after Increasing Oxygen Saturation Targets for Very Preterm Infants: Experience in a Single Center.

    Manley, Brett J; Kuschel, Carl A; Elder, James E; Doyle, Lex W; Davis, Peter G

    2016-01-01

    Randomized trials of oxygen saturation target ranges for extremely preterm infants showed increased survival but increased retinopathy of prematurity with higher compared with lower target ranges. In our center, changing from a target range of 88%-92% to 91%-95% has been associated with increased rates and severity of retinopathy of prematurity. PMID:26548746

  19. Monomicrobial necrotizing fasciitis in a single center: the emergence of Gram-negative bacteria as a common pathogen

    D. Yahav

    2014-11-01

    Conclusions: In our center, 42% of monomicrobial necrotizing fasciitis cases were found to be caused by Gram-negative organisms, mostly E. coli. These infections usually appeared in immunocompromised or postoperative patients, often presented with normal CPK levels, and were associated with high mortality rates.

  20. Tolerability of Shortened Infliximab Infusion Times in Patients With Inflammatory Bowel Diseases : A Single-Center Cohort Study

    Breynaert, Christine; Ferrante, Marc; Fidder, Herma; Van Steen, Kristel; Noman, Maja; Ballet, Vera; Vermeire, Severine; Rutgeerts, Paul; Van Assche, Gert

    2011-01-01

    OBJECTIVES: Scheduled maintenance therapy with infliximab decreases the risk of infusion reactions. Many centers have accelerated infusion times to 1 h in selected patients who tolerate 5 mg/kg infliximab infusions. The aim of this study was to compare the tolerability of 1-h and 2-h infliximab infu

  1. HLW Return from France to Germany - 15 Years of Experience in Public Acceptance and Technical Aspects - 12149

    Since in 1984 the national reprocessing concept was abandoned the reprocessing abroad was the only existing disposal route until 1994. With the amendment of the Atomic Energy Act in 2001 spent fuel management changed completely since from 1 June 2005 any delivery of spent fuel to reprocessing plants was prohibited and the direct disposal of spent fuel became mandatory. Until 2005 the total amount of spent fuel to be reprocessed abroad added up to 6080 t HM, 5309 t HM thereof in France. The waste generated from reprocessing - alternatively an equivalent amount of radioactive material - has to be returned to the country of origin according to the commercial contracts signed between the German utilities and COGEMA, now AREVA NC, in France and BNFL, now INS in UK. In addition the German and the French government exchanged notes with the obligation of both sides to enable and support the return of reprocessing residues or equivalents to Germany. The return of high active vitrified waste from La Hague to the interim storage facility at Gorleben was demanding from the technical view i. e. the cask design and the transport. Unfortunately the Gorleben area served as a target for nuclear opponents from the first transport in 1996 to the latest one in 2011. The protection against sabotage of the railway lines and mass protests needed highly improved security measures. In France and Germany special working forces and projects have been set up to cope with this extraordinary situation. A complex transport organization was established to involve all parties in line with the German and French requirements during transport. The last transport of vitrified residues from France has been completed successfully so far thus confirming the efficiency of the applied measures. Over 15 years there was and still is worldwide no comparable situation it is still unique. Summing up, the exceptional project handling challenge that resulted from the continuous anti-nuclear civil disobedience in

  2. Mucinous Cystic Adenoma of Ovary in a 15-Year-Old Girl with an Unusual Presentation (A Case Report

    Allahbakhsh Rahimi

    2010-05-01

    Full Text Available Introduction: Ovarian cysts are relatively rare in children. Mucinous cystadenomas are rarely encountered in adolescent patients and can reach an enormous size. Mural nodules associated with mucinous tumors of the ovary may represent a benign or malignant process."nCase Presentation: Our case was a 15-year-old female, which referred with a painless abdominal distention gradually appearing during six months. There was no specific symptom only mild discomfort of bowel habits with the regular menstruation. On physical examination, there was complete distention of the abdomen without any tenderness. Ultrasonography revealed a large loculated cystic mass in the abdominopelvic cavity, which contained few septations and mural nodules without any vascularity on color Doppler ultrasonography. All other organs appeared normal. On contrast enhanced CT scan, there was a large intra-peritoneal 280×250×170 mm anteriorly located cystic mass which extended from the upper abdomen down to the lower pelvis displacing and compressing adjacent structures posterolaterally. Multiple enhancing septa and two mural nodules were found in the cystic mass. All solid organs appeared normal and no significant adenopathy or ascitis was detected. According to the above findings, omental cysts, adenexal cysts, urachal cysts, mesenteric cysts were our differential diagnosis. A 10 kg mass was resected (an exophytic cyst in the right ovary and histopathology revealed mucinous cystic adenoma of the right ovary with fibrotic mural nodules. No recurrence was detected after one year."nDiscussion: Mucinous cystadenomas are rarely encountered in adolescent patients and can reach an enormous size. The interesting point of this case was not only because of its rarity but also because of its unusual symptomless manifestation and also fibrotic mural nodules."nKeywords: Mucinous Cystic Adenoma, Ovary, Adolescence

  3. Dental pain among 10–15 year old children attending oral health promoting schools: A cross-sectional study

    Saheer, Abdul; Kousalya, Pallavi Swami; Raju, Rekha; Gubbihal, Radha

    2015-01-01

    Introduction: Dental pain is a major public health problem and one of the consequences of oral diseases which requires significant adjustments in life management leading to decreased quality of life. Objective: To assess prevalence of dental pain and its impact on daily life and to explore its relationship with oral health behavior and clinical oral status among 10-15 year old school children attending oral health promoting schools. Method: This cross sectional study was conducted in 6 schools serving low -middle socio economic strata in Bangalore, India. A total of 1237 children were surveyed for history of dental pain during past 3 month. Participants who reported dental pain completed self-reported oral health behaviour and Child dental pain questionnaire. Clinical oral examination included assessment of dental caries, periodontal status. Data was analyzed using t - test, Chi-square test, ANOVA and Regression Analysis. Results: Prevalence of dental pain was 15.6% (n = 194). Among children with pain, 17%, 43% and 40% reported mild, moderate and severe pain. Impact on daily activities was reported by 66%. Mean DMFT and DMFS was 1.80 and 2.11 Mean deft and defs was 2.47 and 3.41. Multiple logistic regression revealed that severity and impact of dental pain was associated with gender, frequency of tooth brushing, consumption of sweets and deciduous dental caries experience. Conclusion: Prevalence of Dental pain is associated with brushing behavior, consumption of sweets and deciduous dental caries experience, showing need for further attention to these conditions and a need to strengthen preventive and therapeutic dental services. PMID:26942112

  4. Tackling malnutrition: a systematic review of 15-year research evidence from INDEPTH health and demographic surveillance systems

    Samuelina S. Arthur

    2015-10-01

    Full Text Available Background: Nutrition is the intake of food in relation to the body's dietary needs. Malnutrition results from the intake of inadequate or excess food. This can lead to reduced immunity, increased susceptibility to disease, impaired physical and mental development, and reduced productivity. Objective: To perform a systematic review to assess research conducted by the International Network for the Demographic Evaluation of Populations and their Health (INDEPTH of health and demographic surveillance systems (HDSSs over a 15-year period on malnutrition, its determinants, the effects of under and over nutrition, and intervention research on malnutrition in low- and middle-income countries (LMICs. Methods: Relevant publication titles were uploaded onto the Zotero research tool from different databases (60% from PubMed. Using the keywords ‘nutrition’, ‘malnutrition’, ‘over and under nutrition’, we selected publications that were based only on data generated through the longitudinal HDSS platform. All titles and abstracts were screened to determine inclusion eligibility and full articles were independently assessed according to inclusion/exclusion criteria. For inclusion in this study, papers had to cover research on at least one of the following topics: the problem of malnutrition, its determinants, its effects, and intervention research on malnutrition. One hundred and forty eight papers were identified and reviewed, and 67 were selected for this study. Results: The INDEPTH research identified rising levels of overweight and obesity, sometimes in the same settings as under-nutrition. Urbanisation appears to be protective against under-nutrition, but it heightens the risk of obesity. Appropriately timed breastfeeding interventions were protective against malnutrition. Conclusions: Although INDEPTH has expanded the global knowledge base on nutrition, many questions remain unresolved. There is a need for more investment in nutrition research

  5. Online teaching and learning in oceanography: A look back at 15 years of undergraduate general education (Invited)

    Reed, D.

    2013-12-01

    Online courses in higher education have garnered a growing presence in the popular media, yet misperceptions abound. Consequently, a retrospective examination of the evolution of an online oceanography class, first offered to undergraduates at the San Jose State University in the fall semester of 1998, may be especially relevant to the development of future efforts in this field. Since that initial offering, the development of the course, involving the creation of virtual field experiences whereby students take on the role of practicing research oceanographers, has been supported through several awards from the National Science Foundation, principally the Division of Undergraduate Education and the Geoscience Directorate. The online material, organized into expeditions, which focus on the nature of scientific discovery, has evolved over time from a static graphics and text-based format to include video, largely available through YouTube, and animations that take advantage of social media, all to highlight contemporary ocean research. To sustain the project beyond NSF funding, the course has been offered throughout the academic year, and in winter and summer special sessions, to more the 4000 students over the 15 year period since its initial offering. The materials have always been openly available through the course website (http://oceansjsu.com) to institutions throughout the world, long in advance of current MOOC movement. Just as the course format, and available content, have evolved, so have the students enrolled in the class, which now more closely mirror the university student body as a whole. Future efforts in course development should span multi-campus university systems to take advantage of the collective scientific expertise available and to leverage the effort across a larger number of courses and disciplines.

  6. Nutritional transition in children under five years and women of reproductive age: a 15-years trend analysis in Peru.

    Christian Loret de Mola

    Full Text Available BACKGROUND: Rapid urbanization, increase in food availability, and changes in diet and lifestyle patterns have been changing nutritional profiles in developing nations. We aimed to describe nutritional changes in children under 5 years and women of reproductive age in Peru, during a 15-year period of rapid economic development and social policy enhancement. MATERIALS AND METHODS: Trend analyses of anthropometric measures in children of preschool age and women between 15-49 years, using the Peruvian National Demographic and Family Health Surveys (DHS from 1996 to 2011. WHO growth curves were used to define stunting, underweight, wasting and overweight in children 19 years, body mass index (BMI was analyzed both categorically and as a continuous variable. To statistically analyze the trends, we used regression models: Linear and Poisson for continuous and binary outcomes, respectively. RESULTS: We analyzed data from 123 642 women and 64 135 children, from 1996 to 2011. Decreases over time were evidenced for underweight (p<0.001, wasting (p<0.001, and stunting (p<0.001 in children under 5 y. This effect was particularly noted in urban settings. Overweight levels in children reduced (p<0.001, however this reduction stopped, in urban settings, since 2005 (∼12%. Anemia decreased in children and women (p<0.001; with higher reduction in urban (↓43% than in rural children (↓24%. BMI in women aged 15-19 years increased (p<0.001 across time, with noticeable BMI-curve shift in women older than 30 years. Moreover, obesity doubled during this period in women more than 19 y. CONCLUSION: Nutrition transition in Peru shows different patterns for urban and rural populations. Public policies should emphasize targeting both malnutrition conditions--undernutrition/stunting, overweight/obesity and anemia--considering age and place of residence in rapid developing societies like Peru.

  7. Monomicrobial necrotizing fasciitis in a single center: the emergence of Gram-negative bacteria as a common pathogen

    D. Yahav; H. Duskin-Bitan; N. Eliakim-Raz; H. Ben-Zvi; Shaked, H.; Goldberg, E.; Bishara, J.

    2014-01-01

    Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection. It is usually caused by Streptococcus pyogenes and other Gram-positive bacteria. Several reports, however, emphasize the importance of Gram-negative rods in this infection. Methods: We retrospectively studied all cases of monomicrobial necrotizing fasciitis hospitalized in our center during the years 2002–2012. We compared clinical characteristics and outcomes of patients with Gram-negative versus Gram-posi...

  8. Color centers and charge transfer luminescence in a Yb3+-doped PbWO4 single crystal

    Optical absorption and induced color centers are discussed on the base of γ irradiation and annealing treatment in Yb3+ -doped lead-tungstate crystals. The photoluminescence spectra (under UV excitation), the X-ray excited luminescence, and the IR fluorescence (under LD 940-nm infrared excitation) of Yb3+ ions in the PbWO4 crystal was studied at room temperature. γ irradiation with a dose of 105 Gy and subsequent annealing in air could lead to a valence change of the Yb3+ ions and evolvement of color centers in the crystal. Based on the irradiation-induced absorption spectra and annealing, F and F+ centers perturbed by Yb3+ ions are proposed and could be responsible for shaping the absorption and emission spectra of Yb3+ ions in PbWO4 crystals. X-ray excited luminescence measurements were also performed and showed a charge transfer luminescence in heavily doped PWO4 : Yb3+ (2.0 mol%). Annealing treatments in air exerted a distinct influence on the intrinsic luminescence in PbWO4, the IR emission, and the lifetime of Yb3+ ions, but did not show an influence on the charge transfer luminescence. Contrarily, γ-irradiation only shows an influence on the charge transfer luminescence of Yb3+ ions, and has no obvious effect on the intrinsic luminescence of PbWO4.

  9. Expanded Criteria Donor Kidney Transplantation: Comparative Outcome Evaluation Between Single Versus Double Kidney Transplantation at 8 Years: A Single Center Experience.

    De Paolis, P; Colonnelli, R; Favarò, A; Salem, F; Vignally, P; Carriero, C; Iappelli, M; Di Giulio, S

    2016-03-01

    Transplantation of kidneys retrieved from expanded criteria donors is one of the options to expand the pool of available grafts, shorten the waiting time and increase the number of kidney transplant recipients. This study was a retrospective assessment of 99 patients who underwent renal transplantation during the period 2007-2015 with kidneys harvested from expanded criteria donors (ECD) as defined by the United Network for Organ Sharing (UNOS) following routine biopsy of all kidneys obtained by Karpinsky Score. They formed two groups: SKT (67 recipients that received a single kidney) and DKT (32 patients that received dual kidney transplant). An analysis of differences of two groups between graft and patient survival and graft function were performed after 8 years of observation. We observed between two groups the following statistical differences: Donor age (P < .001), basal high risk of recipients (P < .05), wait time before transplant (P < .05), recipient age (P < .001) delayed graft function (P < .005) while we observe similar values of donor renal function, outcome in graft and patient survival and graft function in recipients. The transplantation of kidneys obtained from expanded criteria donor, allows increase in the number of kidney transplants and in the respect of values of biopsy score and the donor renal function, showed in single or dual kidney transplantation with similar graft and patient survival. PMID:27109948

  10. Annealing process of F- and F{sup +}-centers in Al{sub 2}O{sub 3} single crystal induced by fast neutrons irradiation

    Izerrouken, M., E-mail: izerrouken@yahoo.com [Centre de Recherche Nucléaire de Draria, BP.43, Sebala, Draria, Algiers (Algeria); Djouadi, Y. [Université Ferhat Abbas, Faculté des Sciences, Université de Sétif (Algeria); Zirour, H. [Faculté de Physique, Université des Sciences et de la Technologie Houari Boumediene, El-Alia, BP 32, Bab-Ezzouar, Algiers (Algeria)

    2014-01-15

    F and F{sup +} centers were produced in Al{sub 2}O{sub 3} single crystal by fast neutrons (E{sub n} > 1.2 MeV) irradiation at low fluence (4.4 × 10{sup 16} n cm{sup −2}). The evolution of defects intensity as a function of temperature and of time at 493, 623 and 823 K was investigated by UV–visible spectrophotometry technique. It can be concluded from the analysis of isochronal and isothermal annealing data, that the F- and F{sup +}-centers annealing process is complex. At low annealing temperature (<473 K), only F- to F{sup +}-center conversion process takes place. At higher temperature (>493 K) the annealing is due to the superposition of several mechanisms with different activation energies. According to our results, the activation energies needed for both F- and F{sup +}-centers elimination are 0.2, 0.3 and 0.03 eV for temperature range of 300–673 K, 673–873 K and >873 K, respectively.

  11. Evaluation of the Effect of Passive Smoking on Lactoferrin and AST on 12 - 15 Years Old Children and Adolescents

    Niloofar Jenabian

    2015-10-01

    Full Text Available Background: Passive smokers are involuntarily exposed to cigarette or tobacco smoke and as known, inhalation of environmental tobacco smoke is a serious threat. There is little information about the effect of passive smoking on salivary markers and periodontal indices. Objectives: This study investigated the effect of passive smoking on lactoferrin and AST in 12 - 15 years old children and adolescents. Patients and Methods: This case-control analytic correlation type study with no-convenience random sampling method was performed on 160 children aged 12 - 15 who had smokers in their families. The eligible children were divided into two equal groups; 80 cot+ children as case group and 80 cot– children as control group, matched according to age, sex and plaque index. Plaque index was obtained from all subjects. 2 cc unstimulated salivary samples were collected by spitting method. The collected specimens were tested by lactoferrin and AST kits in biochemistry were measured on the day of sampling laboratory. Gingival index Loe and Silness (GI and Probing Pocket Depth (PPD. Results: Mean and Standard Deviation of PPD and GI was 2.01 ± 0.077 and 1.53 ± 0.055 in experimental group and 1.93 ± 0.073 and 1.49 ± 0.046 in control group respectively (P < 0.001. The Mean and Standard Deviation parameters of lactoferrin and AST, in the experimental group was 38.66 ± 25.15 and 13.45 ± 6.33 and in the control group 10.18 ± 6.82 and 6.53 ± 2.65 group, respectively (P < 0.001. Conclusions: Passive smoking can be effective on inflammatory process of periodontal and salivary biomarkers related to inflammation. Lactoferrin was 11 - 104 in case group and 0.5 - 38 in control group. Aspartat aminotransferase in case group was 2.64 - 30.43 and in control group it was 2.16 - 12.02.

  12. Assessment of Mandibular Movements in 10 to 15 Year-old Patients With and Without Temporomandibular Disorders.

    Cortese, Silvina G; Biondi, Ana M; Fridman, Diana E; Guitelman, Ingrid; Farah, Catalina L

    2015-12-01

    The aim of this study was to establish reference values for mandibular movements in 10- to 15-year-olds without dysfunction and compare these values to those in patients of the same age with tempromandibular disorders (TMD) and those found previously in a group of children younger than 11 years old without TMD. Children of both genders who visited the Department of Comprehensive Pediatric Dentistry at Buenos Aires University in 2013 and whose parents or guardians provided consent were evaluated using TMD/RDC by standardized pediatric dentists (Kappa 0.88). Three groups were formed according to diagnostic summary: Group C, without TMD; Group Ia, with myofascial pain, and Group Ib, pain with limited mouth opening. The following variables were analyzed: age, gender and mandibular movements. The sample included 169 patients aged 12.5±1.76 years, of whom 62.36% did not have TMD (C) while 37.27% were diagnosed with muscle disorder (29.58% Ia and 7.69% Ib). For Group C, the following values (in mm) were recorded: maximal unassisted opening: 48.28±6.14; right lateral movement 8.78±2.50; left lateral movement: 9.60±2.64; protrusion: 4.94±2.58 and overbite: 2.98 ± 2.5, with no variation associated to sex, but with differences in the values recorded for all movements compared to those obtained for mixed dentition (p=0.0001). Analysis of mean values for mandibular movements in all 3 groups only revealed differences for maximal unassisted opening (p= 0.0317). With relation to gender, TMD was more frequent in females, with significant differences between Groups C and Ia (p=0.019). In males without dysfunction, average maximal opening was 48.28±6.14mm, with lower values in patients with TMD. Mandibular movements in pediatric patients without TMD showed significant differences according to dentition type and age. PMID:27095624

  13. Increasing numbers of nonaneurysmal subarachnoid hemorrhage in the last 15 years: antithrombotic medication as reason and prognostic factor?

    Konczalla, Juergen; Kashefiolasl, Sepide; Brawanski, Nina; Senft, Christian; Seifert, Volker; Platz, Johannes

    2016-06-01

    OBJECT Subarachnoid hemorrhage (SAH) is usually caused by a ruptured intracranial aneurysm, but in some patients no source of hemorrhage can be detected. More recent data showed increasing numbers of cases of spontaneous nonaneurysmal SAH (NASAH). The aim of this study was to analyze factors, especially the use of antithrombotic medications such as systemic anticoagulation or antiplatelet agents (aCPs), influencing the increasing numbers of cases of NASAH and the clinical outcome. METHODS Between 1999 and 2013, 214 patients who were admitted to the authors' institution suffered from NASAH, 14% of all patients with SAH. Outcome was assessed according to the modified Rankin Scale (mRS) at 6 months. Risk factors were identified based on the outcome. RESULTS The number of patients with NASAH increased significantly in the last 15 years of the study period. There was a statistically significant increase in the rate of nonperimesencephalic (NPM)-SAH occurrence and aCP use, while the proportion of elderly patients remained stable. Favorable outcome (mRS 0-2) was achieved in 85% of cases, but patients treated with aCPs had a significantly higher risk for an unfavorable outcome. Further analysis showed that elderly patients, and especially the subgroup with a Fisher Grade 3 bleeding pattern, had a high risk for an unfavorable outcome, whereas the subgroup of NPM-SAH without a Fisher Grade 3 bleeding pattern had a favorable outcome, similar to perimesencephalic (PM)-SAH. CONCLUSIONS Over the years, a significant increase in the number of patients with NASAH has been observed. Also, the rate of aCP use has increased significantly. Risk factors for an unfavorable outcome were age > 65 years, Fisher Grade 3 bleeding pattern, and aCP use. Both "PM-SAH" and "NPM-SAH without a Fisher Grade 3 bleeding pattern" had excellent outcomes. Patients with NASAH and a Fisher Grade 3 bleeding pattern had a significantly higher risk for an unfavorable outcome and death. Therefore, for further

  14. Trends in the Prevalence of Morbid and Severe Obesity in Australian Children Aged 7-15 Years, 1985-2012

    Garnett, Sarah P.; Baur, Louise A.; Jones, Aimee M. D.; Hardy, Louise L.

    2016-01-01

    Objective Children with severe obesity have greater risk of adverse health outcomes. The purpose of this study was to assess trends in the prevalence of morbid and severe obesity in Australian children between 1985 and 2012. Methods Secondary analysis of four national Australian cross-sectional surveys of measured height/weight in 7–15 year olds: Australian Health and Fitness Survey 1985 (n = 8,486), National Nutrition Survey 1995 (n = 1,541), the National Children’s Nutrition and Physical Activity Survey 2007 (n = 2,585) and the National Health Survey 2012 (n = 2,940). International Obesity Taskforce cut-point was used for morbid obesity (equivalent to a BMI ≥35kg/m2 at age 18 years). Severe obesity class 2 was defined as BMI ≥120% and obesity class 3 as BMI ≥140% of the 95th percentile or a BMI ≥40. Results Between 1985 and 2012 the prevalence of morbid obesity increased from 0.2% to 1.8%, class 2 severe obesity from 0.3% to 2.0%, and class 3 from 0.1% to 0.5%. Children with morbid obesity represented 11.3% of children with obesity in 1985 and increased to 22.5% in 2012 (P = 0.005). Children with severe obesity represented 19.3% of children with obesity in 1985 and increased to 32.0% in 2012 (P = 0.016). The greatest increase was observed between 1995 and 2007. The proportion of children who were classified as morbidly or severely obese was not significantly different between 2007 and 2012, nor was it significantly different between age and sex groups. Conclusion Prevalence of morbid and severe obesity among children is low, but has significantly increased between 1985 and 2012. In contrast to overweight and obese children, children with morbid obesity require tertiary intervention. Failure to treat these children will have significant implications for the individual child and community. PMID:27171503

  15. Toxin Levels and Profiles in Microalgae from the North-Western Adriatic Sea—15 Years of Studies on Cultured Species

    Elena Riccardi

    2012-01-01

    Full Text Available The Northern Adriatic Sea is the area of the Mediterranean Sea where eutrophication and episodes related to harmful algae have occurred most frequently since the 1970s. In this area, which is highly exploited for mollusk farming, the first occurrence of human intoxication due to shellfish consumption occurred in 1989, nearly 10 years later than other countries in Europe and worldwide that had faced similar problems. Until 1997, Adriatic mollusks had been found to be contaminated mostly by diarrhetic shellfish poisoning toxins (i.e., okadaic acid and dinophysistoxins that, along with paralytic shellfish poisoning toxins (i.e., saxitoxins, constitute the most common marine biotoxins. Only once, in 1994, a toxic outbreak was related to the occurrence of paralytic shellfish poisoning toxins in the Adriatic coastal waters. Moreover, in the past 15 years, the Adriatic Sea has been characterized by the presence of toxic or potentially toxic algae, not highly widespread outside Europe, such as species producing yessotoxins (i.e., Protoceratium reticulatum, Gonyaulax spinifera and Lingulodinium polyedrum, recurrent blooms of the potentially ichthyotoxic species Fibrocapsa japonica and, recently, by blooms of palytoxin-like producing species of the Ostreopsis genus. This review is aimed at integrating monitoring data on toxin spectra and levels in mussels farmed along the coast of the Emilia-Romagna region with laboratory studies performed on the species involved in the production of those toxins; toxicity studies on toxic or potentially toxic species that have recently appeared in this area are also reviewed. Overall, reviewed data are related to: (i the yessotoxins producing species P. reticulatum, G. spinifera and L. polyedrum, highlighting genetic and toxic characteristics; (ii Adriatic strains of Alexandrium minutum, Alexandrium ostenfeldii and Prorocentrum lima whose toxic profiles are compared with those of strains of different geographic origins

  16. Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center

    Zhong, Hua; George, Saby; Kauffman, Eric; Guru, Khurshid; Azabdaftari, Gissou; XU, BO

    2014-01-01

    Background To examine histopathologic features and clinical outcomes of intradiverticular bladder carcinomas. Methods Twenty-two consecutive patients with intradiverticular bladder carcinoma treated with either endoscopic transurethral resection or partial or radical cystectomy at a single institution between years of 1995 to 2011. Clinicopathologic characteristics and oncologic outcomes of patients were retrospectively analyzed, including tissue histology re-review by genitourinary pathologi...

  17. Objectively assessed physical activity and aerobic fitness in a population-based sample of Norwegian 9- and 15-year-olds

    Kolle, E; Steene-Johannessen, J; Andersen, Lars Bo; Anderssen, S A

    2010-01-01

    , 48.2 (7.1) mL/min/kg; 9-year-old girls, 42.9 (6.7) mL/min/kg; and 15-year-old girls 41.1 (6.0) mL/min/kg and 15-year-old boys 51.9 (8.0) mL/min/kg. Because of the high participation rate, this study provides a good description of the physical activity and aerobic fitness in the young population...... rate was 89% and 74% among the 9- and 15-year-olds, respectively. Physical activity was assessed objectively by accelerometry, and aerobic fitness was measured directly as peak oxygen uptake during a cycle ergometry test. Boys were more physically active than girls, and 9-year-olds were substantially....... Finally, girls and adolescents seem appropriate targets when promoting physical activity in order to increase the proportion meeting the recommendations....

  18. Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury: a prospective, single-center and double-blind study

    Zhang, Min; He, Huiwei; Wang, Ze-mu; Xu, Zhihui; ZHOU, NINGTIAN; Tao, Zhengxian; Chen, Bo; Li, Chunjian; Zhu, Tiebing; Yang, Di; Wang, Liansheng; Yang, Zhijian

    2014-01-01

    Abstract Cardiac troponin-I (cTnI) and -T (cTnT) are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention (PCI)-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT (cTns) in PCI-related myocardial injury in a Chinese population. A total of 1,008 patients with stable angina pe...

  19. Optimizing CT angiography in patients with Fontan physiology: single-center experience of dual-site power injection

    Aim: To identify adult patients with single-ventricle congenital heart disease and Fontan procedure palliation who have been misdiagnosed with or incompletely evaluated for pulmonary embolism. Additionally, this study was designed to demonstrate that simultaneous, dual-injection of contrast medium into an upper and lower extremity vein is superior to single-injection protocols for CT angiography (CTA) of the chest in this population. Materials and methods: Patients included in the study were retrospectively selected from the Adult Congenital Heart Disease (ACHD) database. Search criteria included history of Fontan palliation and available chest CT examination. Patients were evaluated for (1) type of congenital heart disease and prior operations;(2) indication for initial CT evaluation;(3) route of contrast medium administration for the initial CT examination and resulting diagnosis;(4) whether or not anticoagulation therapy was initiated; and (5) final diagnosis and treatment plan. Results: The query of the ACHD database resulted in 28 individuals or patients with Fontan palliation (superior and inferior venae cavae anastomosed to the pulmonary arteries). Of these, 19 patients with Fontan physiology underwent CTA of the pulmonary circulation, and 17 had suboptimal imaging studies. Unfortunately, seven of these 17 patients (41%) were started on anticoagulation therapy due to a diagnosis of pulmonary embolism that was later excluded. Conclusion: Patients with single-ventricle/Fontan physiology are at risk of thromboembolic disease. Therefore, studies evaluating their complex anatomy must be performed with the optimal imaging protocol to ensure diagnostic accuracy, which is best achieved with dual-injection of an upper and lower extremity central vein. - Highlights: • The adult congenital heart disease population is growing. • Many of these patients have single ventricle/Fontan physiology. • Patients with Fontan physiology are at increased risk for

  20. Thermal modeling of the NASA-Ames Research Center Cryogenic Optical Test Facility and a single-arch, fused-natural-quartz mirror

    Ng, Y. S.; Augason, Gordon C.; Young, Jeffrey A.; Howard, Steven D.; Melugin, Ramsey K.

    1990-01-01

    A thermal model of the dewar and optical system of the Cryogenic Optical Test Facility at NASA-Ames Research Center was developed using the computer codes SINDA and MONTE CARLO. The model was based on the geometry, boundary conditions, and physical properties of the test facility and was developed to investigate heat transfer mechanisms and temperatures in the facility and in test mirrors during cryogenic optical tests. A single-arch, fused-natural-quartz mirror was the first mirror whose thermal loads and temperature distributions were modeled. From the temperature distribution, the thermal gradients in the mirror were obtained. The model predicted that a small gradient should exist for the single arch mirror. This was later verified by the measurement of mirror temperatures. The temperatures, predicted by the model at various locations within the dewar, were in relatively good agreement with the measured temperatures. The model is applicable to both steady-state and transient cooldown operations.

  1. Energy balance in rainfed herbaceous crops in a semiarid environment for a 15-year experiment. 2. Impact of crop rotations.

    Moreno, M. C.; Moreno, M. M.; Lacasta, C.; Tarquis, A. M.; Meco, R.

    2012-04-01

    Energy balances in agriculture production have been widely studied since the 1970s. Researchers have performed detailed energy balances for different crops and farm management systems all over the world in attempts to assess the efficiency and environmental impact of production systems. This work is part of a larger study assessing the effects of three farming systems (conventional, conservation with zero tillage, and organic) and four barley-based crop rotations (barley followed by fallow [B-F], barley in rotation with vetch for hay production [B-V] or sunflower [B-S], and barley monoculture [B-B]), on the energy balance of crop production under the semi-arid conditions over a 15 year period. However, the present work is focused on the crop rotation effect, so farming systems and years are averaged. Experiments were conducted at "La Higueruela" Experimental Farm (4°26' W, 40°04' N, altitude 450 m) (Spanish National Research Council, Santa Olalla, Toledo, central Spain). The climate is semi-arid Mediterranean, with an average seasonal rainfall of 480 mm irregularly distributed. The rotations were simultaneously duplicated to have all phases of each rotation present every year. Results were expressed with respect to one hectare and year for a complete rotation. The energy balance method used required the identification and quantification of all the inputs and outputs implied, and the conversion to energy values by corresponding coefficients. The parameters considered were (i) energy inputs (EI) (diesel, machines, fertilizers, herbicides, seeds) (ii) energy outputs (EO) (energy in the harvested biomass), (iii) net energy produced (NE) (EI - EO), (iv) the energy output/input ratio (O/I), and (v) energy productivity (EP) (Crop yield/EI). Total EI varied from 6.19 GJ ha-1 year-1 for B-F to 11.7 GJ ha-1 year-1 for B-B, that indicates that the energy requirements of barley monoculture (B-B) are almost double those when a fallow period is included in the rotation

  2. Energy balance in rainfed herbaceous crops in a semiarid environment for a 15-year experiment. 1. Impact of farming systems

    Moreno, M. M.; Moreno, C.; Lacasta, C.; Tarquis, A. M.; Meco, R.

    2012-04-01

    During the last years, agricultural practices have led to increase yields by means of the massive consumption on non-renewable fossil energy. However, the viability of a production system does not depend solely on crop yield, but also on its efficiency in the use of available resources. This work is part of a larger study assessing the effects of three farming systems (conventional, conservation with zero tillage, and organic) and four barley-based crop rotations (barley monoculture and in rotation with vetch, sunflower and fallow) on the energy balance of crop production under the semi-arid conditions over a 15 year period. However, the present work is focused on the farming system effect, so crop rotations and years are averaged. Experiments were conducted at "La Higueruela" Experimental Farm (4°26' W, 40°04' N, altitude 450 m) (Spanish National Research Council, Santa Olalla, Toledo, central Spain). The climate is semi-arid Mediterranean, with an average seasonal rainfall of 480 mm irregularly distributed and a 4-month summer drought period. Conventional farming included the use of moldboard plow for tillage, chemical fertilizers and herbicides. Conservation farming was developed with zero tillage, direct sowing and chemical fertilizers and herbicides. Organic farming included the use of cultivator and no chemical fertilizers or herbicides. The energy balance method used required the identification and quantification of all the inputs and outputs implied, and the conversion to energy values by corresponding coefficients. The parameters considered were (i) energy inputs (EI) (diesel, machines, fertilizers, herbicides, seeds) (ii) energy outputs (EO) (energy in the harvested biomass), (iii) net energy produced (NE) (EI - EO), (iv) the energy output/input ratio (O/I), and (v) energy productivity (EP) (Crop yield/EI). EI was 3.0 and 3.5 times higher in conservation (10.4 GJ ha-1 year-1) and conventional (11.7 GJ ha-1 year-1) than in organic farming (3.41 GJ ha-1

  3. Energy balance in rainfed herbaceous crops in a semiarid environment for a 15-year experiment. 2. Impact of crop rotations.

    Moreno, M. C.; Moreno, M. M.; Lacasta, C.; Tarquis, A. M.; Meco, R.

    2012-04-01

    Energy balances in agriculture production have been widely studied since the 1970s. Researchers have performed detailed energy balances for different crops and farm management systems all over the world in attempts to assess the efficiency and environmental impact of production systems. This work is part of a larger study assessing the effects of three farming systems (conventional, conservation with zero tillage, and organic) and four barley-based crop rotations (barley followed by fallow [B-F], barley in rotation with vetch for hay production [B-V] or sunflower [B-S], and barley monoculture [B-B]), on the energy balance of crop production under the semi-arid conditions over a 15 year period. However, the present work is focused on the crop rotation effect, so farming systems and years are averaged. Experiments were conducted at "La Higueruela" Experimental Farm (4°26' W, 40°04' N, altitude 450 m) (Spanish National Research Council, Santa Olalla, Toledo, central Spain). The climate is semi-arid Mediterranean, with an average seasonal rainfall of 480 mm irregularly distributed. The rotations were simultaneously duplicated to have all phases of each rotation present every year. Results were expressed with respect to one hectare and year for a complete rotation. The energy balance method used required the identification and quantification of all the inputs and outputs implied, and the conversion to energy values by corresponding coefficients. The parameters considered were (i) energy inputs (EI) (diesel, machines, fertilizers, herbicides, seeds) (ii) energy outputs (EO) (energy in the harvested biomass), (iii) net energy produced (NE) (EI - EO), (iv) the energy output/input ratio (O/I), and (v) energy productivity (EP) (Crop yield/EI). Total EI varied from 6.19 GJ ha-1 year-1 for B-F to 11.7 GJ ha-1 year-1 for B-B, that indicates that the energy requirements of barley monoculture (B-B) are almost double those when a fallow period is included in the rotation

  4. Low-cost semirigid ureteroscopy is effective for ureteral stones: Experience of a single high volume center

    Roberto Giulianelli

    2014-06-01

    Full Text Available Aim of the study: To demonstrate how, in a center with a large number of patients, as our center is, it is possible to perform ureterolithotripsy using a limited set of instruments. Methods: We evaluated medical charts of our center related to semirigid ureteral ureteroscopy (URS with ureterolithotripsy using Holmium laser performed from July 2004 to July 2011. Overall, 658 URS for ureteral stones were performed in 601 patients, of which 204 in proximal ureter (31%, 86 in the mid (13.06% and 368 (57.76% in the distal ureter. In 504 patients (76.5% ureterohydronephrosis (Grade II-III was observed. In 57 patients (8.6%, we performed a bilateral approach at the same time, but most patients had a solitary distal ureteral stone. 106 patients (16.1% had more than one stone in their distal ureter and 96 (14.8% had a proximal ureteral stone treated in the same surgery as well. Results: The overall stone-free rate for ureteral stones was 86.1% (567/658. Success rates for proximal, medial and distal ureteral stones were 68.13% (139/204 patients, 84.8% (73/86 patients and 96.4% (355/368 patients, respectively. One hundred and twenty patients (18.3% required additional surgical treatment for their stones beyond the initial URS, including a second URS in 97 patients (14.74% and URS plus Retrograde Intra-Renal Surgery (RIRS in 23 patients (3.54%. The overall stonefree rate after the second treatment was 99.3%. Intra-operative complications accounted for 5.92% and consisted of ureteral perforations in 16 pts (2.4%, erosions of urothelium leading to significant bleeding in 15 pts (2.27%, severe pain in 4 pts (0.6%, fever in 3 pts (0.45% and one case of ureteral avulsion (0.15%. Conclusions: This study demonstrates that the use of Holmium laser lithotripsy is a safe and effective means of treating ureteral stones regardless of sex, age, stone location, or stone size. The instrumentation we used was extremely limited, in order to reduce costs related to the

  5. Self-centering fiber alignment structures for high-precision field installable single-mode fiber connectors

    Van Erps, Jürgen; Ebraert, Evert; Gao, Fei; Vervaeke, Michael; Berghmans, Francis; Beri, Stefano; Watté, Jan; Thienpont, Hugo

    2014-05-01

    There is a steady increase in the demand for internet bandwidth, primarily driven by cloud services and high-definition video streaming. Europe's Digital Agenda states the ambitious objective that by 2020 all Europeans should have access to internet at speeds of 30Mb/s or above, with 50% or more of households subscribing to connections of 100Mb/s. Today however, internet access in Europe is mainly based on the first generation of broadband, meaning internet accessed over legacy telephone copper and TV cable networks. In recent years, Fiber-To-The-Home (FTTH) networks have been adopted as a replacement of traditional electrical connections for the `last mile' transmission of information at bandwidths over 1Gb/s. However, FTTH penetration is still very low (approximation and a mathematical model of the spring constant, and finite element-based simulations are carried out to find the maximum first principal stress as well as the stress distribution distribution in the fiber alignment structure. Elastic constants of the order of 104N=m are found to be compatible with a proof stress of 70 M Pa. We show the successful prototyping of 3-spring fiber alignment structures using deep proton writing and investigate their compatibility with replication techniques such as hot embossing and injection moulding. Fiber insertion in our self-centering alignment structures is achieved by means of a dedicated interferometric setup allowing assessment of the fiber facet quality, of the fiber's position in relation to the connector's front and of the spring deformation during fiber insertion. These self-centering structures have the potential to become the basic building blocks for a new generation of field-installable connectors, ultimately breaking the current paradigm of ferrule-based connectivity requiring extensive pre-engineering and highly specialized manpower for field deployment.

  6. Gastrointestinal Fistulas in Acute Pancreatitis With Infected Pancreatic or Peripancreatic Necrosis: A 4-Year Single-Center Experience.

    Jiang, Wei; Tong, Zhihui; Yang, Dongliang; Ke, Lu; Shen, Xiao; Zhou, Jing; Li, Gang; Li, Weiqin; Li, Jieshou

    2016-04-01

    Gastrointestinal (GI) fistula is a well-recognized complication of acute pancreatitis (AP). However, it has been reported in limited literature. This study aimed to evaluate the incidence and outcome of GI fistulas in AP patients complicated with infected pancreatic or peripancreatic necrosis (IPN).Between 2010 and 2013 AP patients with IPN who diagnosed with GI fistula in our center were analyzed in this retrospective study. And we also conducted a comparison between patients with and without GI fistula regarding the baseline characteristics and outcomes.Over 4 years, a total of 928 AP patients were admitted into our center, of whom 119 patients with IPN were diagnosed with GI fistula and they developed 160 GI fistulas in total. Colonic fistula found in 72 patients was the most common form of GI fistula followed with duodenal fistula. All duodenal fistulas were managed by nonsurgical management. Ileostomy or colostomy was performed for 44 (61.1%) of 72 colonic fistulas. Twenty-one (29.2%) colonic fistulas were successfully treated by percutaneous drainage or continuous negative pressure irrigation. Mortality of patients with GI fistula did not differ significantly from those without GI fistula (28.6% vs 21.9%, P = 0.22). However, a significantly higher mortality (34.7%) was observed in those with colonic fistula.GI fistula is a common finding in patients of AP with IPN. Most of these fistulas can be successfully managed with different procedures depending on their sites of origin. Colonic fistula is related with higher mortality than those without GI fistula. PMID:27057908

  7. Pattern of glomerular disease in the Saudi population: A single-center, five-year retrospective study

    Z Nawaz

    2013-01-01

    Full Text Available Glomerular diseases continue to be the leading cause of end-stage renal disease (ESRD globally. Hence, it is important to recognize the pattern of glomerular diseases in different geographical areas in order to understand the patho-biology, incidence and progression of the disorder. Published studies from different centers in Saudi Arabia have reported contradicting results. In this retrospective study, we report our experience at the Armed Forces Hospital, Riyadh, Saudi Arabia. A total of 348 native renal biopsies performed at our center on patients with proteinuria >1 g, hematuria and/or renal impairment during a period of 5 years (between January 2005 and December 2009 were studied by a histopathologist using light microscopy, immunofluorescence and electron microscopy, and were categorized. Results showed that primary glomerular disease accounted for 55.1% of all renal biopsies. The most common histological lesion was focal and segmental glomerulosclerosis (FSGS (27.6%, followed by minimal change disease (MCD (17.7% and membrano-proliferative glomerulonephritis (MPGN (13.0%. Secondary glomerular disease accounted for 37.9% of the glomerular diseases, with lupus nephritis (LN being the most common lesion (54.5%, followed by hypertensive nephrosclerosis (22%, post-infectious glomerulonephritis (7.5%, diabetic nephropathy (DN (6.8% and vasculitides (4.5%. Four percent of all biopsies turned out to be ESRD while biopsy was inadequate in 2.8% of the cases. In conclusion, our study showed that FSGS was the most common primary GN encountered, while LN was the most common secondary GN. We encountered 14 cases of crescentic glomerulonephritis. Also, the prevalence of MPGN, MCD, IgA nephropathy and membranous GN was many folds higher in males when compared with the Western data. We believe that it is mandatory to maintain a Saudi Arabian Renal Biopsy Registry to understand better the pattern of glomerular disease in the Saudi population and to follow

  8. A Single-Institutional Experience of 15 Years of Treating T3 Laryngeal Cancer With Primary Radiotherapy, With or Without Chemotherapy

    Purpose: To retrospectively analyze the outcomes, toxicity, quality of life, and voice quality of patients with T3 laryngeal cancer treated with radiotherapy and to identify subgroups of patients in whom the addition of chemotherapy to radiotherapy is necessary. Methods and Materials: Between March 1996 and November 2009, 170 consecutive patients with T3 tumor were treated with (chemo)radiotherapy. Endpoints of the study were local control (LC), locoregional control (LRC), disease-free survival (DFS), overall survival (OS), late toxicity, quality of life, and voice handicap index. Results: After a median follow-up time of 32 months (range, 7–172), the 3-year actuarial rates of LC, LRC, DFS, and OS were 73%, 70%, 64%, and 61%, respectively, and the 5-year figures were 68%, 65%, 60%, and 49%, respectively. At last follow-up, 84 patients (49.5%) were still alive, 65 of them (77.3%) without local progression. Laryngectomy was performed in 16 patients, leaving 49 patients with anatomic organ preservation, corresponding to an actuarial laryngectomy-free survival of 58.3% at 3 years. The figures for patients treated with chemoradiotherapy and radiotherapy alone were 76.8% and 53.5%, respectively (p = 0.001). Chemoradiotherapy was the only significant predictor for LC on multivariate analysis. The overall 5-year cumulative incidence of late Grade ≥2 toxicity was 28.2%. Chemoradiotherapy, compared with radiotherapy alone, resulted in slight increase in late toxicity and slight deterioration of quality of life and voice-handicap-index scores. However, the differences were statistically not significant. Conclusion: The addition of chemotherapy to radiotherapy in T3 laryngeal cancer significantly improved LC and laryngectomy-free survival without statistically significant increases in late toxicity or deterioration of quality of life or voice handicap index.

  9. A Single-Institutional Experience of 15 Years of Treating T3 Laryngeal Cancer With Primary Radiotherapy, With or Without Chemotherapy

    Al-Mamgani, Abrahim, E-mail: a.al-mamgani@erasmusmc.nl [Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Tans, Lisa; Rooij, Peter van; Levendag, Peter C. [Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2012-07-01

    Purpose: To retrospectively analyze the outcomes, toxicity, quality of life, and voice quality of patients with T3 laryngeal cancer treated with radiotherapy and to identify subgroups of patients in whom the addition of chemotherapy to radiotherapy is necessary. Methods and Materials: Between March 1996 and November 2009, 170 consecutive patients with T3 tumor were treated with (chemo)radiotherapy. Endpoints of the study were local control (LC), locoregional control (LRC), disease-free survival (DFS), overall survival (OS), late toxicity, quality of life, and voice handicap index. Results: After a median follow-up time of 32 months (range, 7-172), the 3-year actuarial rates of LC, LRC, DFS, and OS were 73%, 70%, 64%, and 61%, respectively, and the 5-year figures were 68%, 65%, 60%, and 49%, respectively. At last follow-up, 84 patients (49.5%) were still alive, 65 of them (77.3%) without local progression. Laryngectomy was performed in 16 patients, leaving 49 patients with anatomic organ preservation, corresponding to an actuarial laryngectomy-free survival of 58.3% at 3 years. The figures for patients treated with chemoradiotherapy and radiotherapy alone were 76.8% and 53.5%, respectively (p = 0.001). Chemoradiotherapy was the only significant predictor for LC on multivariate analysis. The overall 5-year cumulative incidence of late Grade {>=}2 toxicity was 28.2%. Chemoradiotherapy, compared with radiotherapy alone, resulted in slight increase in late toxicity and slight deterioration of quality of life and voice-handicap-index scores. However, the differences were statistically not significant. Conclusion: The addition of chemotherapy to radiotherapy in T3 laryngeal cancer significantly improved LC and laryngectomy-free survival without statistically significant increases in late toxicity or deterioration of quality of life or voice handicap index.

  10. Impact of pre-treatment with somatostatin analogs on surgical management of acromegalic patients referred to a single center.

    Bacigaluppi, Susanna; Gatto, Federico; Anania, Pasquale; Bragazzi, Nicola Luigi; Rossi, Diego Criminelli; Benvegnu, Giulia; Nazzari, Elena; Spaziante, Renato; Giusti, Massimo; Ferone, Diego; Zona, Gianluigi

    2016-03-01

    First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin analogs (SSAs) on surgical outcome is still controversial. The aim of this study is to retrospectively evaluate the impact of SSA pre-treatment on biochemical outcome and post-surgical hypopituitarism in a consecutive surgical series from a single referral centre, with data covering 17 years' experience and to investigate the possible predictive value of early postoperative insulin-like factor 1 (IGF-I) on long-term biochemical control. Data from 68 acromegalic patients were revised. Endocrinological long-term follow-up (minimum 6 months) was available for 57 patients. Eighty-eight percent of patients received a single-step surgical treatment (single surgery, with or without adjuvant medical therapy). The remaining 12% underwent a multi-step strategy: redo-surgery (three macroadenomas) and/or radiation (four macro- and two microadenomas). Pre-surgical SSA treatment was performed in 77.9% and resulted in a significant lowering of basal IGF-I values (p = 0.0001). Early post-surgical IGF-I was significantly lower in patients biochemically controlled with single surgery alone (p = 0.016) and after overall treatment strategies (p = 0.005). Normalization of GH and IGF-I was obtained in 56.1%, and normalization of either one of them in 27.8% of patients. No major surgery-related complications occurred. Post-treatment hypopituitarism occurred in 11.9% and was lower in SSA pre-treated patients. Our results well compare with other recently published series. Very early post-surgical IGF-I improvement might be a useful predictor for biochemical disease control. Moreover, our results suggest that pre-surgical treatment with somatostatin analogs seems to prevent

  11. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP ENTITLED ''SINGLE SPIN ASYMMETRIES'' (VOLUME 75)

    YUAN, F.; VOGELSANG, W.

    2005-06-01

    Single-transverse spin asymmetries (SSA) in strong interactions have a long history, starting from the 1970s and 1980s when surprisingly large single-transverse spin asymmetries were observed in p+p {yields} {pi}X and pp {yields} {Lambda} + X, where really none were expected. They have again attracted much interest in recent years from both experimental and theoretical sides. In particular, first measurements by the STAR, PHENIX, and BRAHMS collaborations at RHIC have now become available which again reveal large single transverse spin asymmetries for hadron production in polarized proton proton scattering. This extends the SSA observations from the fixed target energy range to the collider regime. Meanwhile, experimental studies in Deep Inelastic Scattering by the HERMES collaboration at DESY, SMC at CERN, and CLAS at JLab also show a remarkably large SSA in semi-inclusive hadron production, {gamma}*p {yields} {pi}X, when the proton is transversely polarized. On the theoretical side, there are several approaches to understanding SSA within Quantum Chromodynamics (QCD). For example, to explain the large SSAs for hadron production in hadron collisions, a mechanism that takes into account the contribution from quark-gluon-quark correlations (twist-3) in the nucleon was proposed. On the other hand, possible origins of SSA in DIS and hadronic scattering were also found in leading-twist transverse momentum dependent parton distributions. Current theoretical efforts aim at a better conceptual understanding of these two types of mechanisms, and of their connections. We were very happy at this timely date to bring together the theorists and experimentalists of this field to review and discuss the current theoretical status and the latest experimental results. The whole workshop contained 25 formal talks, both experiment (15) and theory (10), and a few informal talks and many fruitful discussions. The topics covered all the relevant SSA observables, including in Deep

  12. Successful treatment of anastomotic jejunal varices with N-butyl-2-cyanoacrylate (Histoacryl): single-center experience.

    Gubler, C; Glenck, M; Pfammatter, T; Bauerfeind, P

    2012-08-01

    Obscure gastrointestinal bleeding can lead to extensive diagnostic work-up, as well as repeated episodes of hospitalizations with significant morbidity. Patients with a previous small-bowel anastomosis seem to be prone to varices at this site, even in the absence of portal hypertension. We report here five cases with varices of this type. All the anastomoses in these patients were reached using overtube-assisted single- or double-balloon enteroscopy. The bleeding varices were treated by injecting N-butyl-2-cyanoacrylate (Histoacryl). Bleeding was stopped in all five patients without any adverse events, requiring one session in four patients and a second session in one patient. PMID:22833023

  13. Safety of atrial fibrillation ablation with novel multi-electrode array catheters on uninterrupted anticoagulation-a single-center experience.

    Hayes, Christopher Ruslan

    2012-02-01

    INTRODUCTION: A recent single-center report indicated that the performance of atrial fibrillation ablation in patients on uninterrupted warfarin using a conventional deflectable tip electrode ablation catheter may be as safe as periprocedural discontinuation of warfarin and bridging with heparin. Novel multi-electrode array catheters for atrial fibrillation ablation are currently undergoing clinical evaluation. While offering the possibility of more rapid atrial fibrillation ablation, they are stiffer and necessitate the deployment of larger deflectable transseptal sheaths, and it remains to be determined if they increase the risk of cardiac perforation and vascular injury. Such potential risks would have implications for a strategy of uninterrupted periprocedural anticoagulation. METHOD AND RESULTS: We audited the safety outcomes of our atrial fibrillation ablation procedures using multi-electrode array ablation catheters in patients on uninterrupted warfarin (CHADS2 score>or=2) and in patients not on warfarin (uninterrupted aspirin). Two bleeding complications occurred in 49 patients on uninterrupted warfarin, both of which were managed successfully without longterm sequelae, and no bleeding complication occurred in 32 patients not on warfarin (uninterrupted aspirin). There were no thromboembolic events or other complication with either anticoagulant regimen. CONCLUSION: Despite the larger diameter and increased stiffness of multi-electrode array catheters and their deflectable transseptal sheaths, their use for catheter ablation in patients with atrial fibrillation on uninterrupted warfarin in this single-center experience does not appear to be unsafe, and thus, an adequately powered multicenter prospective randomized controlled trial should be considered.

  14. Short-term and medium-term outcomes of transapical aortic valve implantation as a single-strategy approach: one center's experience

    Mokráček, Aleš; Pešl, Ladislav; Kurfirst, Vojtěch; Šulda, Mirek

    2015-01-01

    Introduction Transcatheter aortic valve replacement has been developed as an alternative option for surgical high-risk or inoperable patients with severe symptomatic aortic stenosis. Aim of the study Aim of the study was to evaluate the outcomes of patients undergoing transapical aortic valve replacement as a single-strategy option by a single-center multidisciplinary heart team. Material and methods Between June 2009 and December 2014, 41 patients underwent transapical transcatheter aortic valve implantation (TA-TAVI) at our institution. All patients received Edwards SAPIEN balloon expandable pericardial valves (Edwards Lifesciences, Irvine, CA, USA). Our center followed a “clear transapical strategy” for all patients. Results The mean age of the patients was 79.6 years, and the mean logistic EuroSCORE was 21.06 ± 12.82%. Fifteen patients (36.6%) underwent redo operations. Complications included stroke (n = 1), re-exploration for bleeding or cardiac tamponade (n = 4), renal failure requiring temporary hemodialysis (n = 4) and permanent pacemaker implantation (n = 3). There were no myocardial infarctions or coronary obstruction. The total 30-day mortality rate was 17.1% (7 patients). Postoperative intensive care unit stay was 4.6 ± 5.7 days, and mean hospitalization was 11.6 ± 7.2 days. Conclusions The TA-TAVI approach provides good results in terms of early and midterm outcomes. This approach is feasible and safe for patients who have high surgical risk. PMID:26336490

  15. Benign painful shoulder syndrome. Initial results of a single-center prospective randomized radiotherapy dose-optimization trial

    Background and purpose: To compare the efficacy of two different dose-fractionation schedules for radiotherapy of patients with benign painful shoulder syndrome. Patients and methods: Between February 2006 and February 2010, 312 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received radiotherapy with an orthovoltage technique. One radiotherapy course consisted of 6 single fractions in 3 weeks. In case of insufficient remission of pain after 6 weeks, a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. The endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after radiotherapy using a visual analogue scale (VAS) and a comprehensive pain score (CPS). Results: The overall response rate for all patients was 83% directly after and 85% 6 weeks after radiotherapy. The mean VAS values before, directly after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 56.8 ± 23.7 and 53.2 ± 21.8 (p = 0.158), 38.2 ± 26.1 and 34.0 ± 24.5 (p = 0.189), and 33.0 ± 27.2 and 23.7 ± 22.7 (p = 0.044), respectively. The mean CPS before, directly after, and 6 weeks after treatment was 9.7 ± 3.0 and 9.5 ± 2.7 (p = 0.309), 6.1 ± 3.6 and 5.4 ± 3.6 (p = 0.096), 5.3 ± 3.7 and 4.1 ± 3.7 (p = 0.052), respectively. Despite a slight advantage in the VAS analysis for the 1.0 Gy group for delayed response, the CPS analysis revealed no statistically significant differences between the two single-dose trial arms for early (p = 0.652) and delayed response quality (p = 0.380). Conclusion: Radiotherapy is an effective treatment option for the management of benign painful shoulder syndrome. Concerning radiation protection, the dose for a radiotherapy series is recommended not to exceed 3-6 Gy. (orig.)

  16. Benign painful shoulder syndrome. Initial results of a single-center prospective randomized radiotherapy dose-optimization trial

    Ott, O.J.; Hertel, S.; Gaipl, U.S.; Frey, B.; Schmidt, M.; Fietkau, R. [University Hospital Erlangen (Germany). Department of Radiation Oncology

    2012-12-15

    Background and purpose: To compare the efficacy of two different dose-fractionation schedules for radiotherapy of patients with benign painful shoulder syndrome. Patients and methods: Between February 2006 and February 2010, 312 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received radiotherapy with an orthovoltage technique. One radiotherapy course consisted of 6 single fractions in 3 weeks. In case of insufficient remission of pain after 6 weeks, a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. The endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after radiotherapy using a visual analogue scale (VAS) and a comprehensive pain score (CPS). Results: The overall response rate for all patients was 83% directly after and 85% 6 weeks after radiotherapy. The mean VAS values before, directly after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 56.8 {+-} 23.7 and 53.2 {+-} 21.8 (p = 0.158), 38.2 {+-} 26.1 and 34.0 {+-} 24.5 (p = 0.189), and 33.0 {+-} 27.2 and 23.7 {+-} 22.7 (p = 0.044), respectively. The mean CPS before, directly after, and 6 weeks after treatment was 9.7 {+-} 3.0 and 9.5 {+-} 2.7 (p = 0.309), 6.1 {+-} 3.6 and 5.4 {+-} 3.6 (p = 0.096), 5.3 {+-} 3.7 and 4.1 {+-} 3.7 (p = 0.052), respectively. Despite a slight advantage in the VAS analysis for the 1.0 Gy group for delayed response, the CPS analysis revealed no statistically significant differences between the two single-dose trial arms for early (p = 0.652) and delayed response quality (p = 0.380). Conclusion: Radiotherapy is an effective treatment option for the management of benign painful shoulder syndrome. Concerning radiation protection, the dose for a radiotherapy series is recommended not to exceed 3-6 Gy. (orig.)

  17. Maternal Jail Time, Conviction, and Arrest as Predictors of Children's 15-Year Antisocial Outcomes in the Context of a Nurse Home Visiting Program

    Shlafer, Rebecca J.; Poehlmann, Julie; Donelan-McCall, Nancy

    2012-01-01

    Data from the Nurse-Family Partnership intervention program were analyzed to compare the "selection" versus "unique" effects of maternal jail time on adolescent antisocial and health risk outcomes. Data from 320 women and their firstborn children were available from the prenatal, birth, and 15-year assessments. Consistent with a selection…

  18. Equity in the Turkish Education System: A Multilevel Analysis of Social Background Influences on the Mathematics Performance of 15-Year-Old Students

    Özdemir, Caner

    2016-01-01

    This paper aims to discover the level of equity in the Turkish education system using maths outcomes of 15-year-old students in the Programme for International Student Assessment (PISA) exam. In order to do that, associations between various social background variables and student performance are analysed via multilevel models. Female pupils,…

  19. Do Migrant Girls Perform Better than Migrant Boys? Deviant Gender Differences between the Reading Scores of 15-Year-Old Children of Migrants Compared to Native Pupils

    Dronkers, Jaap; Kornder, Nils

    2014-01-01

    In this paper, we analyse the gender differences between the educational performance of 15-year-old children of migrants from specific regions of origin countries living in different destination countries with the Programme for International Student Assessment (PISA) 2009 wave. We study whether this gender difference of migrant pupils deviates…

  20. The High Performance of Dutch and Flemish 15-Year-Old Native Pupils: Explaining Country Differences in Math Scores between Highly Stratified Educational Systems

    Prokic-Breuer, Tijana; Dronkers, Jaap

    2012-01-01

    This paper aims to explain the high scores of 15-year-old native pupils in The Netherlands and Flanders by comparing them with the scores of pupils in countries with the same highly stratified educational system: Wallonia, the German "Lander," the Swiss German cantons, and Austria. We use the data from the Programme for International Pupil…