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Sample records for 116th ncab min

  1. OnlineMin

    Brodal, Gerth Stølting; Moruz, Gabriel; Negoescu, Andrei

    2015-01-01

    In the field of online algorithms paging is one of the most studied problems. For randomized paging algorithms a tight bound of Hk on the competitive ratio has been known for decades, yet existing algorithms matching this bound have high running times. We present a new randomized paging algorithm...... OnlineMin that has optimal competitiveness and allows fast implementations. In fact, if k pages fit in internal memory the best previous solution required O(k2) time per request and O(k) space. We present two implementations of OnlineMin which use O(k) space, but only O(logk) worst case time and O...

  2. Se min kjole

    Bogen Se min kjole udkom i anledning af 50-året for de første ordinationer af kvindelige præster i den danske folkekirke i 1948. Bogen giver analyser af, hvad kvindelige præster har betydet for præsterollen og for prædikengenren; den fortæller om de første kvindelige præsters liv og syn på...

  3. 改进的 Min-Min 算法研究%Research on Improved Min-Min Algorithm

    邓树强; 刘波; 庞雄文

    2011-01-01

    Task scheduling is an important part of grid system, and the task scheduling algorithm is the most important in the task scheduling. After the research of Min-Min algorithm, this paper points out the shortcomings of Min-Min algorithm. With the goal of grid task scheduling, several improved Min-Min algorithms are drawn out in optimal scheduling, load balancing, quality of service and the charge. Then this paper introduces the advantages and disadvantages of the improved algorithms. It provides some reference to improve the algorithms in the future.%任务调度是网格系统中重要的一环,而任务的调度算法更显得是重中之重.本文对Min-Min算法进行分析,指出Min-Min算法存在的不足.结合网格任务调度的目标,分别从最优调度、负我均衡、服务质量、价格费用4方面提出几种改进的Min-Min算法,重点介绍算法思路,指出算法的优缺点,为以后的改进工作提供参考.

  4. Instant MinGW starter

    Shpigor, Ilya

    2013-01-01

    This is a Starter guide designed to enable the reader to start using MinGW to develop Microsoft Windows applications as quickly, and as efficiently, as possible. This book is for C and C++ developers who are looking for new and effective instruments to use in application development for Microsoft Windows. No experience of MinGW is needed: this book will guide you through the essentials to get you using the software like a pro in a matter of hours.

  5. USGS 1-min Dst index

    Gannon, J.L.; Love, J.J.

    2011-01-01

    We produce a 1-min time resolution storm-time disturbance index, the USGS Dst, called Dst8507-4SM. This index is based on minute resolution horizontal magnetic field intensity from low-latitude observatories in Honolulu, Kakioka, San Juan and Hermanus, for the years 1985-2007. The method used to produce the index uses a combination of time- and frequency-domain techniques, which more clearly identifies and excises solar-quiet variation from the horizontal intensity time series of an individual station than the strictly time-domain method used in the Kyoto Dst index. The USGS 1-min Dst is compared against the Kyoto Dst, Kyoto Sym-H, and the USGS 1-h Dst (Dst5807-4SH). In a time series comparison, Sym-H is found to produce more extreme values during both sudden impulses and main phase maximum deviation, possibly due to the latitude of its contributing observatories. Both Kyoto indices are shown to have a peak in their distributions below zero, while the USGS indices have a peak near zero. The USGS 1-min Dst is shown to have the higher time resolution benefits of Sym-H, while using the more typical low-latitude observatories of Kyoto Dst. ?? 2010.

  6. Self-organization of the MinE ring in subcellular Min oscillations

    Derr, Julien; Hopper, Jason T.; Sain, Anirban; Rutenberg, Andrew D.

    2009-01-01

    We model the self-organization of the MinE ring that is observed during subcellular oscillations of the proteins MinD and MinE within the rod-shaped bacterium {\\it Escherichia coli}. With a steady-state approximation, we can study the MinE-ring generically -- apart from the other details of the Min oscillation. Rebinding of MinE to depolymerizing MinD filament tips controls MinE ring formation through a scaled cell shape parameter $\\tilde{r}$. We find two types of E-ring profiles near the fil...

  7. Min-protein oscillations in round bacteria

    Huang, Kerwyn Casey; Wingreen, Ned S.

    2004-12-01

    In rod-shaped Escherichia coli cells, the Min proteins, which are involved in division-site selection, oscillate from pole-to-pole. The homologs of the Min proteins from the round bacterium Neisseria gonorrhoeae also form a spatial oscillator when expressed in wild-type and round, rodA- mutants of E. coli, suggesting that the Min proteins form an oscillator in N. gonorrhoeae. Here we report that a numerical model for Min-protein oscillations in rod-shaped cells also produces oscillations in round cells (cocci). Our numerical results explain why the MinE-protein rings found in wild-type E. coli are absent in round mutants. In addition, we find that for round cells there is a minimum radius below which oscillations do not occur, and a maximum radius above which oscillations become mislocalized. Finally, we demonstrate that Min-protein oscillations can select the long axis in nearly round cells based solely on geometry, a potentially important factor in division-plane selection in cocci.

  8. 30-min x 30-min Terrestrial Mean Free-Air Anomalies

    National Oceanic and Atmospheric Administration, Department of Commerce — The 30-min x 30-min Terrestrial Mean Free-Air Gravity Anomaly and Geoid Undulations Data Base was compiled and developed by the Ohio State University. This data...

  9. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE

    Hu, Zonglin; Gogol, Edward P.; Lutkenhaus, Joe

    2002-01-01

    Selection of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE. In this study we have further investigated the molecular basis for this oscillation by examining the interaction of MinD with phospholipid vesicles. We found that MinD bound to phospholipid vesicles in the presence of ATP and, upon binding, assembled into a well-ordered helical array that deformed the vesicle...

  10. Learnability of min-max pattern classifiers

    Yang, Ping-Fai; Maragos, Petros

    1991-11-01

    This paper introduces the class of thresholded min-max functions and studies their learning under the probably approximately correct (PAC) model introduced by Valiant. These functions can be used as pattern classifiers of both real-valued and binary-valued feature vectors. They are a lattice-theoretic generalization of Boolean functions and are also related to three-layer perceptrons and morphological signal operators. Several subclasses of the thresholded min- max functions are shown to be learnable under the PAC model.

  11. min kilpailukyky Saksan markkinoilla

    Hakala, Johanna

    2007-01-01

    Tutkimuksessa selvitettiin Pohjois-Satakunnassa Jämijärvellä sijaitsevan Jämin kilpailukyky matkailukohteena Saksan markkinoilla, eritoten Baijerin alueella, verrattuna Pohjois-Suomen viiteen suureen matkailukohteeseen Levi, Ylläs, Pyhä-Luosto, Ruka ja Vuokatti. Tutkimus loi katsauksen matkailualaan ja sen tulevaisuuden kehitykseen. Tutkimus ei käsitellyt pohjoisen lomakohteita yleisesti totuttuina laskettelukeskuksina, vaan ympärivuotisina lomakohteina ja keskittyi vertailussa kohteiden koko...

  12. 60wrd/min art critic

    Waxman, Lori

    2015-01-01

    Tiré du site Internet de Onestar Press: "The following was announced on the windows of a small blue house at dOCUMENTA (13) : The “60 wrd/min art critic” is available. ­Reviews are free of charge, and are written here on Mondays, Wednesdays and Saturdays ­between the hours of 1 and 6 p.m. Lori Waxman will spend 25 minutes ­looking at submitted work and writing a 200-word review. Thoughtful responses are guaranteed. Completed reviews will be ­published in the Hessische/­Niedersächsische­Allgem...

  13. Preprocessing of Min Ones Problems: A Dichotomy

    Kratsch, Stefan

    2009-01-01

    A parameterized problem consists of a classical problem and an additional component, the so-called parameter. This point of view allows a formal definition of preprocessing: Given a parameterized instance (I,k), a polynomial kernelization computes an equivalent instance (I',k') of size and parameter bounded by a polynomial in k. We give a complete classification of Min Ones Constraint Satisfaction problems, i.e., Min Ones SAT(\\Gamma), with respect to admitting or not admitting a polynomial kernelization (unless NP \\subseteq coNP/poly). For this we introduce the notion of mergeability. If all relations of the constraint language \\Gamma are mergeable, then a new variant of sunflower kernelization applies, based on non-zero-closed cores. We obtain a kernel with O(k^{d+1}) variables and polynomial total size, where d is the maximum arity of a constraint in \\Gamma, comparing nicely with the bound of O(k^{d-1}) vertices for the less general and arguably simpler d-Hitting Set problem. Otherwise, any relation in \\Gam...

  14. 15. 7-min periodicity in OJ287

    Valtaoja, E.; Lehto, H.; Teerikorpi, P.; Korhonen, T.; Valtonen, M.; Teraesranta, H.; Salonen, E.; Urpo, S.; Tiuri, M.; Piirola, V.; Saslaw, W.C.

    1985-03-14

    The BL Lac-type object OJ287, with a redshift z = 0.306 and a luminosity exceeding 10/sup 47/ erg s/sup -1/ at maximum light, is among the brightest and most violently variable objects of its class. Rapid variations, with timescales of a few hours or less, have been reported over a wide range of wavelengths and also in polarization, imposing strong constraints on the size and dynamics of the source. The detection of periodic variations in OJ287, or in any other compact extragalactic source, would be even more important, as these could be related to rotation or orbital motion in the source. So far the only searches sensitive to periodic variations shorter than 1 h are the photometric observations of Visvanathan and Elliot, Frohlich et al. and Kiplinger, in which a 40-min period in OJ287 was respectively found, confirmed and not detected. Here the detection of a 15.7-min periodic flux variation in OJ287 in April 1981 at 37 GHz is reported. The source has been subsequently monitored for 265 h at 22 and 37 GHz, as well as in optical photometry, and the same period has been seen in simultaneous observations. The peak-peak amplitude of the variation is 1-10% of the total intensity. Other periods may also exist. 17 references, 3 figures.

  15. Max-min and min-max approximation problems for normal matrices revisited

    Tichý, Petr

    Praha: Institute of Computer Science AS CR, 2014 - (Bílková, H.; Rozložník, M.; Tichý, P.). s. 95-95 ISBN 978-80-87136-16-4. [SNA ’14. Seminar on Numerical Analysis. 27.01.2014-31.01.2014, Nymburk] Institutional support: RVO:67985807 Keywords : matrix approximation problems * min-max and max-min approximation problems * best approximation * normal matrices Subject RIV: BA - General Mathematics

  16. Strength training improves 5-min all-out performance following 185 min of cycling

    Rønnestad, Bent R.; Hansen, Ernst Albin; Raastad, Truls

    2009-01-01

    To investigate the effects of heavy strength training on the mean power output in a 5-min all-out trial following 185 min of submaximal cycling at 44% of maximal aerobic power output in well-trained cyclists. Twenty well-trained cyclists were assigned to either usual endurance training combined with heavy strength training [E+S; n=11 (♂=11)] or to usual endurance training only [E; n=9 (♂=7, ♀=2)]. The strength training performed by E+S consisted of four lower body exercises [3 × 4–10 repetiti...

  17. Min-Max Spaces and Complexity Reduction in Min-Max Expansions

    Gaubert, Stephane, E-mail: Stephane.Gaubert@inria.fr [Ecole Polytechnique, INRIA and CMAP (France); McEneaney, William M., E-mail: wmceneaney@ucsd.edu [University of California San Diego, Dept. of Mech. and Aero. Eng. (United States)

    2012-06-15

    Idempotent methods have been found to be extremely helpful in the numerical solution of certain classes of nonlinear control problems. In those methods, one uses the fact that the value function lies in the space of semiconvex functions (in the case of maximizing controllers), and approximates this value using a truncated max-plus basis expansion. In some classes, the value function is actually convex, and then one specifically approximates with suprema (i.e., max-plus sums) of affine functions. Note that the space of convex functions is a max-plus linear space, or moduloid. In extending those concepts to game problems, one finds a different function space, and different algebra, to be appropriate. Here we consider functions which may be represented using infima (i.e., min-max sums) of max-plus affine functions. It is natural to refer to the class of functions so represented as the min-max linear space (or moduloid) of max-plus hypo-convex functions. We examine this space, the associated notion of duality and min-max basis expansions. In using these methods for solution of control problems, and now games, a critical step is complexity-reduction. In particular, one needs to find reduced-complexity expansions which approximate the function as well as possible. We obtain a solution to this complexity-reduction problem in the case of min-max expansions.

  18. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE

    Suefuji, Kyoko; Valluzzi, Regina; RayChaudhuri, Debabrata

    2002-01-01

    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control. The mechanism underlying MinD oscillation remains poorly understood. Here, we demonstrate that purified MinD assembles into protein filaments in the presence of ATP. Incubation with phospholipid vesicles further stimulates MinD polymerization. Addition of pu...

  19. OPT-Min-Min:基于Min-Min网格资源调度算法的优化%OPT-Min-Min:the Grid Resources Scheduling Algorithm Based on Load Balance

    张忠平; 温利娟

    2014-01-01

    网格是由大量地理上分布的异构资源组成的高性能并行计算系统,网格资源调度算法在网格资源管理中具有重要意义.在众多的启发式调度算法中,Min-Min调度算法取得了良好的调度结果,但是Min-Min调度算法导致负载不平衡.本文针对Min-Min调度算法存在负载不均,采用重负载资源的任务分配给轻负载资源执行来均衡负载的策略,提出OPT-Min-Min算法,提高资源利用率,达到较小的完成时间;最后采用Braun等人提出的仿真模型基准来验证算法有效性.

  20. Minä mediatanssija? : erikoiskoulutusluokkalaisten tanssi-ihanteet ja minäkuva tanssitaiteen perusopetuksessa

    Lähteenmäki, Carita

    2011-01-01

    Tämä kirjallinen tutkielma on osa Turun ammattikorkeakoulun tanssinopettajan (AMK) tutkintoon sisältyvää opinnäytetyökokonaisuutta. Taiteellinen osa opinnäytetyöstä on koreografia Lähelle lausuttua. Kirjallinen osa on tutkielma tanssia erikoiskoulutusluokalla harrastavien nuorten ihanteista, minäkuvasta ja mediakäyttäytymisestä. Aineistona käytetään teoreettista tietoa mediapsykologiasta, 35 tanssinoppilaan kyselylomakevastaukset sekä kolmen tanssinopettajaopiskelijan sähköpostikysely ja yhde...

  1. QoS Guided Min-Min Heuristic for Grid Task Scheduling

    HE XiaoShan(何晓珊); SUN XianHe(孙贤和); Gregor von Laszewski

    2003-01-01

    Task scheduling is an integrated component of computing. With the emergence of Grid and ubiquitous computing, new challenges appear in task scheduling based on properties such as security, quality of service, and lack of central control within distributed administrative domains. A Grid task scheduling framework must be able to deal with these issues. One of the goals of Grid task scheduling is to achieve high system throughput while matching applications with the available computing resources. This matching of resources in a non-deterministically shared heterogeneous environment leads to concerns over Quality of Service (QoS). In this paper a novel QoS guided task scheduling algorithm for Grid computing is introduced. The proposed novel algorithm is based on a general adaptive scheduling heuristics that includes QoS guidance.The algorithm is evaluated within a simulated Grid environment. The experimental results show that the new QoS guided Min-Min heuristic can lead to significant performance gain for a variety of applications. The approach is compared with others based on the quality of the prediction formulated by inaccurate information.

  2. Research on Min-Min Scheduling Algorithm and Improved Algorithm in Grid%Min-Min调度算法及改进在网格中的研究

    严华; 周永刚; 蔡瑞英

    2009-01-01

    网格是一门新兴技术.首先介绍了经典的Min-Min调度算法,然后考虑网络环境对QoS的要求,对Min-Min调度算法进行改进,最后用SimGrid对Min-Min调度算法及提出的改进算法进行仿真,比较了两个算法的性能.

  3. Improved Min-Min scheduling algorithm based on QoS%基于QoS的改进Min-Min调度算法

    林志杰; 张友斌; 顾静

    2015-01-01

    The classical Min-Min scheduling algorithm exists the problems of load unbalance, the low resource utilization rate and long processing time. To solve these problems, a scheduling algorithm named P-Min is proposed, which is based on task priority and combined greedy scheduling strategy to schedule. Experimental results show that, as compared with the Min-Min algorithm, the P-Min Algorithm improves 18% in load balance and 8.03% in the overall task execution time, respectively.%针对经典 Min–Min 调度算法存在负载不均,资源利用率低,处理时间长等问题,提出了 P–Min 算法。该算法根据任务的优先级并结合贪心算法来实现调度。仿真结果表明: P–Min算法在负载均衡的资源利用率方面较Min–Min算法提高了17%,任务总体执行时间调高了8.03%。

  4. Minä teen majani yrttitarhaan (3/4 C)

    2011-01-01

    Laulun sanat: Minä teen majani yrttitarhaan, jossa linnut laulaa saamull' varhain. En mä tee sitä itselleni, vaan sille jota minä rakastan. En mä tee sitä itselleni, vaan sille jota minä rakastan!

  5. MinFinder v2.0: An improved version of MinFinder

    Tsoulos, Ioannis G.; Lagaris, Isaac E.

    2008-10-01

    A new version of the "MinFinder" program is presented that offers an augmented linking procedure for Fortran-77 subprograms, two additional stopping rules and a new start-point rejection mechanism that saves a significant portion of gradient and function evaluations. The method is applied on a set of standard test functions and the results are reported. New version program summaryProgram title: MinFinder v2.0 Catalogue identifier: ADWU_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWU_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC Licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 14 150 No. of bytes in distributed program, including test data, etc.: 218 144 Distribution format: tar.gz Programming language used: GNU C++, GNU FORTRAN, GNU C Computer: The program is designed to be portable in all systems running the GNU C++ compiler Operating system: Linux, Solaris, FreeBSD RAM: 200 000 bytes Classification: 4.9 Catalogue identifier of previous version: ADWU_v1_0 Journal reference of previous version: Computer Physics Communications 174 (2006) 166-179 Does the new version supersede the previous version?: Yes Nature of problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques can be trapped in any local minimum. Global optimization is then the appropriate tool. For example, solving a non-linear system of equations via optimization, one may encounter many local minima that do not correspond to solutions, i.e. they are far from zero. Solution method: Using a uniform pdf, points are sampled from a rectangular domain. A clustering technique, based on a typical distance

  6. Automatic generation of min-weighted persistent formations

    Luo Xiao-Yuan; Li Shao-Bao; Guan Xin-Ping

    2009-01-01

    This paper researched into some methods for generating min-weighted rigid graphs and min-weighted persistent graphs.Rigidity and persistence are currently used in various studies on coordination and control of autonomous multi-agent formations.To minimize the communication complexity of formations and reduce energy consumption,this paper introduces the rigidity matrix and presents three algorithms for generating min-weighted rigid and min weighted persistent graphs.First,the existence of a min-weighted rigid graph is proved by using the rigidity matrix,and algorithm 1 is presented to generate the min-weighted rigid graphs.Second,the algorithm 2 based on the rigidity matrix is presented to direct the edges of min-weighted rigid graphs to generate min-weighted persistent graphs.Third,the formations with range constraints are considered,and algorithm 3 is presented to find whether a framework can form a min-weighted persistent formation.Finally,some simulations are given to show the efficiency of our research.

  7. Task scheduling based on Min-Min genetic algorithm in grid%基于Min-Min遗传算法的网格任务调度方法

    马景奕; 隋兵; 舒万能

    2008-01-01

    针对网格环境异构、分布等特点,在现有的任务调度算法的基础上,结合Min-Min算法和遗传算法的优点,提出了一种基于Min-Min遗传算法的任务调度方法.仿真实验表明:在网格环境下,该算法具有合理性和高效性.

  8. Research and improvement of Min-Min scheduling algorithm%Min-Min调度算法的研究与改进

    杜玉霞; 刘方爱; 郭磊

    2010-01-01

    在动态、异构的网格环境中,任务调度是复杂并且极具挑战性的一个问题.在分析任务调度算法的基础上,着重研究了经典的Min-Min调度算法,分析了Min-Min调度算法的缺陷,即负载不均衡,并且不能从经济的角度来实现调度.针对负载均衡和经济这两方面来对Min-Min调度算法进行改进,提出了基于价格改进的Min-Min调度算法,分析表明,改进后的算法在一定程度上平衡了负载,并且节省了一部分费用,说明了算法的可行性.

  9. Min-Max decoding for non binary LDPC codes

    Savin, Valentin

    2008-01-01

    Iterative decoding of non-binary LDPC codes is currently performed using either the Sum-Product or the Min-Sum algorithms or slightly different versions of them. In this paper, several low-complexity quasi-optimal iterative algorithms are proposed for decoding non-binary codes. The Min-Max algorithm is one of them and it has the benefit of two possible LLR domain implementations: a standard implementation, whose complexity scales as the square of the Galois field's cardinality and a reduced complexity implementation called selective implementation, which makes the Min-Max decoding very attractive for practical purposes.

  10. Résolution exacte de MinSAT

    Li, Chu Min; Manya, Felip; Quan, Zhe; Zhu, Zhu

    2010-01-01

    MinSAT est le problème consistant à trouver une affectation qui minimise le nombre de clauses satisfaites dans une formule CNF. Nous présentons une approche originale pour résoudre MinSAT de façon exacte, qui repose sur le codage MaxSAT et les solveurs MaxSAT. Notre étude empirique fournit la preuve que, en l'absence de spécifiques solveurs exacts pour MinSAT, l'approche générique proposée dans ce papier est compétitive.

  11. Projekti Min-E-Max kohtumine Saksamaal / Katrin Arge

    Arge, Katrin

    2005-01-01

    Oktoobri keskel toimus Lõuna-Saksamaa väikelinnas Oberderdingenis Hispaania, Portugali, Ungari, Leedu, Eesti ja Saksamaa õpetajate kohtumine seoses Euroopa Liidu poolt rahastatava Comenius1 projektiga Min-E-Max (minimum energy input maximum output)

  12. Teadlastele on Saksamaa kogemus hindamatu / Mart Min, Jaan Aru

    Min, Mart, 1943-

    2012-01-01

    Oma muljeid Saksamaalt jagavad Tallinna Tehnikaülikooli professor Mart Min, kes on viibinud õppejõuna Saksamaal ja Frankfurdis Max Plancki instituudis doktorantuuris aju ja teadvust uuriv noorteadlane Jaan Aru

  13. Scheduling algorithm based on modified Min-Min in grid%基于Min-Min改进后的网格调度算法

    魏天宇; 曾文华; 黄宝边

    2005-01-01

    在对网格计算中现有的任务调度算法的研究基础上,仔细分析了调度算法中最经典的Min-Min算法,指出了该算法中所存在的负载不平衡的缺点,并在该算法的基础上提出了一个改进模型来有效的平衡负载,同时给出了相应的Balance-Min-Min算法.最后采用SimGrid工具包对所提出的算法进行仿真,验证了算法的合理性和高效性.

  14. 一类带约束min-max-min问题的区间算法%An Interval Algorithm for a Class of Constrained min-max-min Problems

    陈美蓉; 曹德欣

    2009-01-01

    构造了求解一类带不等式约束的min-max-min问题的区间算法,其中目标函数和约束函数都是一阶连续可微函数,证明了方法的收敛性,给出了数值算例.该方法可以同时求出问题的最优值和全部全局最优解,是有效和可靠的.

  15. Self-Corrected Min-Sum decoding of LDPC codes

    Savin, Valentin

    2008-01-01

    In this paper we propose a very simple but powerful self-correction method for the Min-Sum decoding of LPDC codes. Unlike other correction methods known in the literature, our method does not try to correct the check node processing approximation, but it modifies the variable node processing by erasing unreliable messages. However, this positively affects check node messages, which become symmetric Gaussian distributed, and we show that this is sufficient to ensure a quasi-optimal decoding performance. Monte-Carlo simulations show that the proposed Self-Corrected Min-Sum decoding performs very close to the Sum-Product decoding, while preserving the main features of the Min-Sum decoding, that is low complexity and independence with respect to noise variance estimation errors.

  16. Mapping the MinE Site Involved in Interaction with the MinD Division Site Selection Protein of Escherichia coli

    Ma, Lu-Yan; King, Glenn; Rothfield, Lawrence

    2003-01-01

    Interactions between the MinD and MinE proteins are required for proper placement of the Escherichia coli division septum. The site within MinE that is required for interaction with MinD was mapped by studying the effects of site-directed minE mutations on MinD-MinE interactions in yeast two-hybrid and three-hybrid experiments. This confirmed that the MinE N-terminal domain is responsible for the interaction of MinE with MinD. Mutations that interfered with the interaction defined an extended...

  17. The min--max construction of minimal surfaces

    Colding, T; C. De Lellis

    2003-01-01

    In this paper we survey with complete proofs some well--known, but hard to find, results about constructing closed embedded minimal surfaces in a closed 3-dimensional manifold via min--max arguments. This includes results of J. Pitts, F. Smith, and L. Simon and F. Smith.

  18. Multistability and dynamic transitions of intracellular Min protein patterns.

    Wu, Fabai; Halatek, Jacob; Reiter, Matthias; Kingma, Enzo; Frey, Erwin; Dekker, Cees

    2016-01-01

    Cells owe their internal organization to self-organized protein patterns, which originate and adapt to growth and external stimuli via a process that is as complex as it is little understood. Here, we study the emergence, stability, and state transitions of multistable Min protein oscillation patterns in live Escherichia coli bacteria during growth up to defined large dimensions. De novo formation of patterns from homogenous starting conditions is observed and studied both experimentally and in simulations. A new theoretical approach is developed for probing pattern stability under perturbations. Quantitative experiments and simulations show that, once established, Min oscillations tolerate a large degree of intracellular heterogeneity, allowing distinctly different patterns to persist in different cells with the same geometry. Min patterns maintain their axes for hours in experiments, despite imperfections, expansion, and changes in cell shape during continuous cell growth. Transitions between multistable Min patterns are found to be rare events induced by strong intracellular perturbations. The instances of multistability studied here are the combined outcome of boundary growth and strongly nonlinear kinetics, which are characteristic of the reaction-diffusion patterns that pervade biology at many scales. PMID:27279643

  19. Linked Min.B configuration inside high shear magnetic surface

    Arrangement of the l = m baseball coils to form the toroidally linked Min.B configuration with large rotational transform is studied analytically and numerically. By an optimization the closed magnetic isobars are obtained inside the last closed magnetic surface having practical volume and high shear if l = 3 baseball coils are arranged. (auth.)

  20. Complexity of tropical and min-plus linear prevarieties

    Grigoriev, Dima

    2012-01-01

    A tropical (or min-plus) semiring is a set $\\mathbb{Z}$ (or $\\mathbb{Z \\cup \\{\\infty\\}}$) endowed with two operations: $\\oplus$, which is just usual minimum, and $\\odot$, which is usual addition. In tropical algebra the vector $x$ is a solution to a polynomial $g_1(x) \\oplus g_2(x) \\oplus...\\oplus g_k(x)$, where $g_i(x)$'s are tropical monomials, if the minimum in $\\min_i(g_{i}(x))$ is attained at least twice. In min-plus algebra solutions of systems of equations of the form $g_1(x)\\oplus...\\oplus g_k(x) = h_1(x)\\oplus...\\oplus h_l(x)$ are studied. In this paper we consider computational problems related to tropical linear system. We show that the solvability problem (both over $\\mathbb{Z}$ and $\\mathbb{Z} \\cup \\{\\infty\\}$) and the problem of deciding the equivalence of two linear systems (both over $\\mathbb{Z}$ and $\\mathbb{Z} \\cup \\{\\infty\\}$) are equivalent under polynomial-time reduction to mean payoff games and are also equivalent to analogous problems in min-plus algebra. In particular, all these proble...

  1. Theoretical Prediction of Disrupted Min Oscillation in Flattened Escherichia coli.

    Jeff B Schulte

    Full Text Available The dynamics of the Min-protein system help Escherichia coli regulate the process of cell division by identifying the center of the cell. While this system exhibits robust bipolar oscillations in wild-type cell shapes, recent experiments have shown that when the cells are mechanically deformed into wide, flattened out, irregular shapes, the spatial regularity of these oscillations breaks down. We employ widely used stochastic and deterministic models of the Min system to simulate cells with flattened shapes. The deterministic model predicts strong bipolar oscillations, in contradiction with the experimentally observed behavior, while the stochastic model, which is based on the same reaction-diffusion equations, predicts more spatially irregular oscillations. We further report simulations of flattened but more symmetric shapes, which suggest that the flattening and lateral expansion may contribute as much to the irregular oscillation behavior as the asymmetry of the cell shapes.

  2. Weighted Max-Min Resource Allocation for Frequency Selective Channels

    Zehavi, Ephi; Levanda, Ronny; Han, Zhu

    2010-01-01

    In this paper, we discuss the computation of weighted max-min rate allocation using joint TDM/FDM strategies under a PSD mask constraint. We show that the weighted max-min solution allocates the rates according to a predetermined rate ratio defined by the weights, a fact that is very valuable for telecommunication service providers. Furthermore, we show that the problem can be efficiently solved using linear programming. We also discuss the resource allocation problem in the mixed services scenario where certain users have a required rate, while the others have flexible rate requirements. The solution is relevant to many communication systems that are limited by a power spectral density mask constraint such as WiMax, Wi-Fi and UWB.

  3. Min-Plus Techniques for Set-Valued State Estimation

    Kallapur, Abhijit G; McEneaney, William M; Petersen, Ian R

    2012-01-01

    This article approaches deterministic filtering via an application of the min-plus linearity of the corresponding dynamic programming operator. This filter design method yields a set-valued state estimator for discrete-time nonlinear systems (nonlinear dynamics and output functions). The energy bounds in the process and the measurement disturbances are modeled using a sum quadratic constraint. The filtering problem is recast into an optimal control problem in the form of a Hamilton-Jacobi-Bellman (HJB) equation, the solution to which is obtained by employing the min-plus linearity property of the dynamic programming operator. This approach enables the solution to the HJB equation and the design of the filter without recourse to linearization of the system dynamics/ output equation.

  4. Compensatory Fuzzy Min-Max Neural Network for Object Recognition

    Paras A. Tolia

    2013-06-01

    Full Text Available Object recognition is important component in computer vision.Object recognition system (ORS is mainly concern withdetermining the identity of the object in the image. Many ORSare available but they are quite computationally expensive orthey are not invariant under rotation, translation and scale (RTS.More over fuzzy min max neural network (FMNN classifierhaving problem with classification and gradation error. Theobject recognition system is divided into two steps namely,feature extraction and pattern classification. Feature Extractionpart consist of rotation, translation and scale invariant features.These features are used to train fuzzy min max neural networkwith compensatory neuron architecture (FMCNs. FMCN useshyperbox fuzzy sets to represent the pattern classes. The conceptcompensatory neurons are inspired from the reflex system ofhuman brain which takes over the control in hazardous condition.Compensatory neurons are getting activated when the testingsample falls in the overlapped regions of different classes.

  5. Min-max minimal hypersurfaces in non-compact manifolds

    Montezuma, Rafael

    2014-01-01

    In this work we prove the existence of embedded closed minimal hypersurfaces in non-compact manifolds containing a bounded open subset with smooth and strictly mean-concave boundary and a natural behavior on the geometry at infinity. For doing this, we develop a modified min-max theory for the area functional following Almgren and Pitts' setting, to produce minimal surfaces with intersecting properties.

  6. Optimal Control of (Min,+) Linear Time-Varying Systems

    Lahaye, Sébastien; Boimond, Jean-Louis; Hardouin, Laurent

    1999-01-01

    International audience The class of discrete event dynamic systems involving only synchronization phenomena can be seen as linear time-invariant systems in a particular algebraic structure called (min,+) algebra. In the same framework, this paper deals with linear time-varying systems, that is, systems whose parameters may change as functions of time. For example, in a manufacturing system the number of working machines, or the number of trains running in a closed network of railway connec...

  7. John Disks, the Apollonian Metric, and Min-Max Properties

    M Huang; S Ponnusamy; X Wang

    2010-02-01

    The main results of this paper are characterizations of John disks–the simply connected proper subdomains of the complex plane that satisfy a twisted double cone connectivity property. One of the characterizations of John disks is an analog of a result due to Gehring and Hag who found such a characterization for quasidisks. In both situations the geometric condition is an estimate for the domain’s hyperbolic metric in terms of its Apollonian metric. The other characterization is in terms of an arc min-max property.

  8. Creating a Scandinavian brunch for BistroCafe Min Krog

    Häkämies, Pilvi

    2015-01-01

    This thesis is about creating a Scandinavian brunch menu and a brunch product for BistroCafé Min Krog located in Kirkkonummi, Finland. The goal of this thesis is to give a clear framework for creating a brunch menu for a restaurant. I planned and executed the Scandinavian brunch used as a case in this thesis in October 2013. The timeframe of this thesis is from October 2013 until August 2015. The thesis consists of theoretical background related to new-product development and menu planni...

  9. A Uniform Min-Max Theorem with Applications in Cryptography

    Vadhan, Salil P.; Zheng, Colin Jia

    2013-01-01

    We present a new, more constructive proof of von Neumann’s Min-Max Theorem for two-player zero-sum game — specifically, an algorithm that builds a near-optimal mixed strategy for the second player from several best-responses of the second player to mixed strategies of the first player. The algorithm extends previous work of Freund and Schapire (Games and Economic Behavior ’99) with the advantage that the algorithm runs in poly(n) time even when a pure strategy for the first player is a distri...

  10. Minätys! Lapsen itsetunnon tukeminen draamallisin menetelmin

    Visuri, Sanna-Maaria

    2015-01-01

    Tutkimuksen tarkoituksena on selvittää miten draamamenetelmillä voi tukea lapsen itsetunnon kehitystä. Opinnäytetyö on tehty yhteistyössä Kokkolan sosiaali- ja terveystoimen alaisen yksikön Isokadun perhepalvelukeskuksen kanssa. Kohderyhmänä oli lastensuojelun tarpeessa olevien perheiden 8-12 vuotiaat lapset. Kokonaisuudessaan työ koostuu toiminnallisesta osuudesta sekä teoriaosuudesta. Tutkimuksen toiminnallisessa osuudessa järjestin draamapainotteisen Minätys- pajan helmikuussa 1.2.14-2...

  11. Grayscale Image Compression Based on Min Max Block Truncating Coding

    Hilal Almarabeh

    2011-11-01

    Full Text Available This paper presents an image compression techniques based on block truncating coding. In this work, a min max block truncating coding (MM_BTC is presented for grayscale image compression relies on applying dividing image into non-overlapping blocks. MM_BTC differ from other block truncating coding such as block truncating coding (BTC in the way of selecting the quantization level in order to remove redundancy. Objectives measures such as: Bit Rate (BR, Mean Square Error (MSE, Peak Signal to Noise Ratio (PSNR, and Redundancy (R, were used to present a detailed evaluation of MM_BTC of image quality.

  12. Min-max event-triggered computation tree logic

    Pallab Dasgupta; P P Chakrabarti; Jatindra Kumar Deka

    2002-04-01

    Very often timing verification involves the analysis of the timings of discrete events such as signal changes, sending and receiving of signals, and sensitization of edge-triggered circuit components. The main bottleneck in verifying timing properties of timed finite state machines (FSM) has been the inherent complexity of verifying timed properties (PSPACE-complete for timed extensions of computational tree logic (CTL)). Often however, we are interested in the best case or worst case timings between events. In this paper we introduce a temporal query language called Min-max Event-Triggered Computational Tree Logic for expressing such extremal queries on the timings of events and show that such queries can be evaluated in time polynomial in the size of the system times the length of the formula.

  13. The US Army HazMin probe model

    In 1987, the US Department of Defense (DOD) established a goal of reducing the quantity of hazardous waste generated by DOD facilities by 50%. To help achieve this goal, the US Army Production Base Modernization Activity (PBMA) has contracted with the Pacific Northwest Laboratory (PNL) to develop decision support software to be used in the Army-wide hazardous waste minimization (HazMin) program. The resulting waste minimization prioritization software has been named the Project Opportunity and Benefit Evaluation (PROBE) model. PROBE can be used to evaluate both waste stream and project priorities. PROBE operates on any IBM-compatible personal computer hardware with at least 640K of memory and 5 megabytes of available hard disk space. PROBE was developed under the direction of PBMA, which retains unlimited rights to the Federal version of PROBE. PBMA encourages other DOD services and other Federal agencies to use PROBE to assist in their own waste minimization programs. PNL is also considering developing a copyrighted version of PROBE for the commercial market. PROBE was written using FoxPro 2.0 application development software, and runs as an executable file from either MS-DOS or Windows. The software can be loaded onto a single high-capacity floppy disk in a compressed format and can be transferred onto hard disk, ready to operate, via a simple start-up routine

  14. Transmembrane Helix Assembly by Max-Min Ant System Algorithm.

    Sujaree, Kanon; Kitjaruwankul, Sunan; Boonamnaj, Panisak; Supunyabut, Chirayut; Sompornpisut, Pornthep

    2015-12-01

    Because of the rapid progress in biochemical and structural studies of membrane proteins, considerable attention has been given on developing efficient computational methods for solving low-to-medium resolution structures using sparse structural data. In this study, we demonstrate a novel algorithm, max-min ant system (MMAS), designed to find an assembly of α-helical transmembrane proteins using a rigid helix arrangement guided by distance constraints. The new algorithm generates a large variety with finite number of orientations of transmembrane helix bundle and finds the solution that is matched with the provided distance constraints based on the behavior of ants to search for the shortest possible path between their nest and the food source. To demonstrate the efficiency of the novel search algorithm, MMAS is applied to determine the transmembrane packing of KcsA and MscL ion channels from a limited distance information extracted from the crystal structures, and the packing of KvAP voltage sensor domain using a set of 10 experimentally determined constraints, and the results are compared with those of two popular used stochastic methods, simulated annealing Monte Carlo method and genetic algorithm. PMID:26058409

  15. Min-cut segmentation of cursive handwriting in tabular documents

    Davis, Brian L.; Barrett, William A.; Swingle, Scott D.

    2015-01-01

    Handwritten tabular documents, such as census, birth, death and marriage records, contain a wealth of information vital to genealogical and related research. Much work has been done in segmenting freeform handwriting, however, segmentation of cursive handwriting in tabular documents is still an unsolved problem. Tabular documents present unique segmentation challenges caused by handwriting overlapping cell-boundaries and other words, both horizontally and vertically, as "ascenders" and "descenders" overlap into adjacent cells. This paper presents a method for segmenting handwriting in tabular documents using a min-cut/max-flow algorithm on a graph formed from a distance map and connected components of handwriting. Specifically, we focus on line, word and first letter segmentation. Additionally, we include the angles of strokes of the handwriting as a third dimension to our graph to enable the resulting segments to share pixels of overlapping letters. Word segmentation accuracy is 89.5% evaluating lines of the data set used in the ICDAR2013 Handwriting Segmentation Contest. Accuracy is 92.6% for a specific application of segmenting first and last names from noisy census records. Accuracy for segmenting lines of names from noisy census records is 80.7%. The 3D graph cutting shows promise in segmenting overlapping letters, although highly convoluted or overlapping handwriting remains an ongoing challenge.

  16. Variable operator technique and the min-max theorem

    Sambhu Nath Datta

    2000-09-01

    We investigate a variation method where the trial function is generated from the application of a variable operator on a reference function. Two conditions are identified, one for obtaining a maximum and another for a minimum. Although the conditions are easy to understand, the overall formulation is somewhat unusual as each condition gives rise to a two-step variation process. As an example, projection operators are used to form the variable operator, and by this tactics one obtains the new interpretation that the pseudopotential formalism is in fact equivalent to a minimax procedure. The two-step variational process is nevertheless more flexible than the pseudopotential formalism, for it can also be used when the variable operator isnot manifestly expressed in terms of projectors. This is illustrated by a comparison of the two-step method with the variational solution of Dirac’s relativistic electron equation. The same comparison leads to an alternative proof that the process of maximizing energy by varying the – coupling operator eliminates all negative-energy contributions from a trial spinor. The latter observation is crucial for the derivation of the min-max theorem in relativistic quantum mechanics.

  17. Topic Modeling for Keyword Extraction: using Natural Language Processing methods for keyword extraction in Portal Min@s

    Arnaldo Candido Junior

    2015-12-01

    Full Text Available Este artigo tem o objetivo da avaliar a aplicação de dois métodos automáticos eficientes na extração de palavras-chave, usados pelas comunidades da Linguística de Corpus e do Processamento da Língua Natural para gerar palavras-chave de textos literários: o WordSmith Tools e o Latent Dirichlet Allocation (LDA. As duas ferramentas escolhidas para este trabalho têm suas especificidades e técnicas diferentes de extração, o que nos levou a uma análise orientada para a sua performance. Objetivamos entender, então, como cada método funciona e avaliar sua aplicação em textos literários. Para esse fim, usamos análise humana, com conhecimento do campo dos textos usados. O método LDA foi usado para extrair palavras-chave por meio de sua integração com o Portal Min@s: Corpora de Fala e Escrita, um sistema geral de processamento de corpora, concebido para diferentes pesquisas de Linguística de Corpus. Os resultados do experimento confirmam a eficácia do WordSmith Tools e do LDA na extração de palavras-chave de um corpus literário, além de apontar que é necessária a análise humana das listas em um estágio anterior aos experimentos para complementar a lista gerada automaticamente, cruzando os resultados do WordSmith Tools e do LDA. Também indicam que a intuição linguística do analista humano sobre as listas geradas separadamente pelos dois métodos usados neste estudo foi mais favorável ao uso da lista de palavras-chave do WordSmith Tools.

  18. Genetic Mapping of the minB Locus in Escherichia coli K-12

    Schaumberg, Thomas H.; Kuempel, Peter L.

    1983-01-01

    The minB (minicell production) locus of Escherichia coli K-12 was mapped by transduction using bacteriophage P1. minB is located at min 25.6, between purB (min 25.2) and dadR (min 25.8). The mapping was facilitated by the use of insertion zcf-236::Tn10, which is inserted at min 25.4.

  19. a Min-Cut Based Filter for Airborne LIDAR Data

    Ural, Serkan; Shan, Jie

    2016-06-01

    LiDAR (Light Detection and Ranging) is a routinely employed technology as a 3-D data collection technique for topographic mapping. Conventional workflows for analyzing LiDAR data require the ground to be determined prior to extracting other features of interest. Filtering the terrain points is one of the fundamental processes to acquire higher-level information from unstructured LiDAR point data. There are many ground-filtering algorithms in literature, spanning several broad categories regarding their strategies. Most of the earlier algorithms examine only the local characteristics of the points or grids, such as the slope, and elevation discontinuities. Since considering only the local properties restricts the filtering performance due to the complexity of the terrain and the features, some recent methods utilize global properties of the terrain as well. This paper presents a new ground filtering method, Min-cut Based Filtering (MBF), which takes both local and global properties of the points into account. MBF considers ground filtering as a labeling task. First, an energy function is designed on a graph, where LiDAR points are considered as the nodes on the graph that are connected to each other as well as to two auxiliary nodes representing ground and off-ground labels. The graph is constructed such that the data costs are assigned to the edges connecting the points to the auxiliary nodes, and the smoothness costs to the edges between points. Data and smoothness terms of the energy function are formulated using point elevations and approximate ground information. The data term conducts the likelihood of the points being ground or off-ground while the smoothness term enforces spatial coherence between neighboring points. The energy function is optimized by finding the minimum-cut on the graph via the alpha-expansion algorithm. The resulting graph-cut provides the labeling of the point cloud as ground and off-ground points. Evaluation of the proposed method on

  20. Detection of active bile leak with Gd-EOB-DTPA enhanced MR cholangiography: Comparison of 20–25 min delayed and 60–180 min delayed images

    Cieszanowski, Andrzej, E-mail: andrzej.cieszanowski@wum.edu.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Stadnik, Anna, E-mail: aniaws@yahoo.com [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Lezak, Aleksandra, E-mail: aleksandralezak@gmail.com [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Maj, Edyta, E-mail: em26@wp.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Zieniewicz, Krzysztof, E-mail: krzysztof.zieniewicz@wum.edu.pl [Chair and Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Rowinska-Berman, Katarzyna, E-mail: kasiarowinska@wp.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Grudzinski, Ireneusz P., E-mail: ireneusz.grudzinski@wum.edu.pl [Department of Toxicology, Medical University of Warsaw, Faculty of Pharmacy, ul. Banacha 1, 02-097 Warsaw (Poland); Krawczyk, Marek, E-mail: marek.krawczyk@wum.edu.pl [Chair and Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Rowiński, Olgierd, E-mail: olgierd.rowinski@wum.edu.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland)

    2013-12-01

    Objectives: The purpose of this study was to assess the value of contrast-enhanced magnetic resonance cholangiography (MRC) performed in different time delays after injection of gadoxetic acid disodium (Gd-EOB-DTPA) for the diagnosis of active bile leak. Methods: This retrospective analysis included Gd-EOB-DTPA enhanced MR images of 34 patients suspected of bile leak. Images were acquired 20–25 min after Gd-EOB-DTPA injection. If there was inadequate contrast in the bile ducts then delayed images after 60–90 min and 150–180 min were obtained. Results were correlated with intraoperative findings, ERCP results, clinical data, laboratory tests, and follow-up examinations. Results: Gd-EOB-DTPA enhanced MRC yielded an overall sensitivity of 96.4%, specificity of 100% and accuracy of 97.1% for the diagnosis of an active bile leak. The sensitivity of 20–25 min delayed MR images was 42.9%, of combined 20–25 min and 60–90 min delayed images was 92.9% and of combined 20–25 min, 60–90 min and 150–180 min delayed images was 96.4%. Conclusions: Gd-EOB-DTPA enhanced MRC utilizing delayed phase images was effective for detecting the presence and location of active bile leaks. The images acquired 60–180 min post-injection enabled identification of bile leaks even in patients with a dilated biliary system or moderate liver dysfunction.

  1. Cross sections for the formation of sup(114m)In and sup(116m)In on bombardment of cadmium by deuterons

    Cross sections for sup(114m)In and sup(116m)In production by (d,xn) reactions on natural cadmium were measured by the stacked foils activation method. The results are compared with the maximum cross sections estimated from other published studies. Thick target yield for Cd (d,xn) sup(114m)In reactions were determined for different irradiation times and as a function of deuteron energy. (author)

  2. GridSim Simulation of Min-min Task Scheduling Algorithm in Grid%网格任务调度算法Min-min的GridSim模拟实现

    苏翊

    2010-01-01

    该文用模拟方法研究网格中的任务调度问题.首先对Min-min算法进行分析,然后用Gridsim对Min-min调度算法进行模拟实现,阐述了实现过程,并统计模拟结果,对Min-min算法的MakeSpan和负载等性能进行了分析,验证了模拟实现过程的正确性.

  3. Isolation and characterization of topological specificity mutants of minD in Bacillus subtilis

    Karoui, M E; Errington, J

    2001-01-01

    In rod-shaped bacteria such as Bacillus subtilis, division site selection is mediated by MinC and MinD, which together function as a division inhibitor. Topological specificity is imposed by DivIVA, which ensures that MinCD specifically inhibits division close to the cell poles, while allowing division at mid-cell. MinD plays a central role in this process, as it positions and activates MinC and is dependent on DivIVA for its own positioning at the poles. To investigate MinD activities furthe...

  4. 无向图中边不相交Min-Min问题的复杂度%Hardness of the edge-disjoint Min-Min problem in undirected graphs

    郭龙坤; 沈鸿

    2012-01-01

    We show incorrectness of the NP-completeness proof of Bhatia et al.for the edge-disjoint Min-Min problem in undirected graphs,by giving a counter example that is an unsatisfiable 3SAT instance but was classified satisfiable in the proof of Bhatia etal. We then give a proof of NP-completeness of the edge-disjoint Min-Min problem in undirected graphs,based on a reduction from the MAX-2SAT problem.%Bhatia等指出,Xu等对无向图中的边不相交Min-Min问题的NP-完全性证明并不成立.我们首先用一个反例指出Bhatia等对Xu等的NP-完全性证明的修正依然存在错误.基于一个从MAX-2SAT的归约,我们给出了一个无向图中边不相交Min-Min问题的NP-完全性的正确证明.

  5. Results evaluation of max rule, min rule and product rule in score fusion multibiometric systems

    Shekhar Karanwal,

    2010-07-01

    Full Text Available this paper discusses about unibiometric systems, multibiometric systems, product rule, max rule and min rule of score level fusion. Score level fusion is used to generate scores of a person. Min max normalization scheme is used for normalization which normalizes scoresbetween 0 and 1. The proposed method also evaluates the results between product rule, min rule and max rule.

  6. 基于带抑制弧的Petri网的min-min算法模型研究%Research on min-min algorithm model based on Petri net model with inhibitor arcs

    傅游; 花嵘; 田银花

    2010-01-01

    为了解决已有的min-min算法Petri网模型不能模拟min-min算法运行过程的问题,根据min-min算法的调度特点,利用带抑制弧的Petri网提出了一种算法模型,该模型运行过程可以严格模拟min-min算法对独立任务集的调度顺序,能够正确地描述独立任务调度系统使用min-min算法的情况.最后对该模型的空间复杂度以及每调度一个任务模型的变化情况进行了分析,随着独立任务的调度执行,该基于带抑制弧的Petri网的变迁数和弧数会随之减少,模型的空间复杂度会不断降低.

  7. Changes in the Min oscillation pattern before and after cell birth.

    Juarez, Jennifer R; Margolin, William

    2010-08-01

    The Min system regulates the positioning of the cell division site in many bacteria. In Escherichia coli, MinD migrates rapidly from one cell pole to the other. In conjunction with MinC, MinD helps to prevent unwanted FtsZ rings from assembling at the poles and to stabilize their positioning at midcell. Using time-lapse microscopy of growing and dividing cells expressing a gfp-minD fusion, we show that green fluorescent protein (GFP)-MinD often paused at midcell in addition to at the poles, and the frequency of midcell pausing increased as cells grew longer and cell division approached. At later stages of septum formation, GFP-MinD often paused specifically on only one side of the septum, followed by migration to the other side of the septum or to a cell pole. About the time of septum closure, this irregular pattern often switched to a transient double pole-to-pole oscillation in the daughter cells, which ultimately became a stable double oscillation. The splitting of a single MinD zone into two depends on the developing septum and is a potential mechanism to explain how MinD is distributed equitably to both daughter cells. Septal pausing of GFP-MinD did not require MinC, suggesting that MinC-FtsZ interactions do not drive MinD-septal interactions, and instead MinD recognizes a specific geometric, lipid, and/or protein target at the developing septum. Finally, we observed regular end-to-end oscillation over very short distances along the long axes of minicells, supporting the importance of geometry in MinD localization. PMID:20543068

  8. Local Optimization for Task Scheduling Algorithm Based on QoS Guided Min-min%基于QoS Guided Min-min任务调度算法局部优化

    王祖析

    2011-01-01

    在对网格环境中现有任务调度算法的研究基础上,分析了调度算法中经典的Min-Min算法和Qos GuidedMin-min算法,指出了这些算法中所存在的负载不平衡的缺点,在此基础上,提出对Qos Guided Min-min算法进行局部优化和改进,并采用SimGrid模拟器对优化的算法进行仿真,结果表明,优化改进后的算法合理,具有较高的性能.

  9. Stuttering Min oscillations within E. coli bacteria: a stochastic polymerization model

    We have developed a 3D off-lattice stochastic polymerization model to study the subcellular oscillation of Min proteins in the bacteria Escherichia coli, and used it to investigate the experimental phenomenon of Min oscillation stuttering. Stuttering was affected by the rate of immediate rebinding of MinE released from depolymerizing filament tips (processivity), protection of depolymerizing filament tips from MinD binding and fragmentation of MinD filaments due to MinE. Processivity, protection and fragmentation each reduce stuttering, speed oscillations and MinD filament lengths. Neither processivity nor tip protection were, on their own, sufficient to produce fast stutter-free oscillations. While filament fragmentation could, on its own, lead to fast oscillations with infrequent stuttering; high levels of fragmentation degraded oscillations. The infrequent stuttering observed in standard Min oscillations is consistent with short filaments of MinD, while we expect that mutants that exhibit higher stuttering frequencies will exhibit longer MinD filaments. Increased stuttering rate may be a useful diagnostic to find observable MinD polymerization under experimental conditions. (paper)

  10. A Grid Task Scheduling Method Based on Min-Min and ACO Algorithm%基于Min-Min和蚁群算法的网格任务调度方法

    黄学雨; 何焕; 戴志晃

    2009-01-01

    网格任务调度是网格计算的研究热点,也是一个NP难问题.文章结合Min-Min算法和蚁群算法的优点,提出了一种基于Min-Min蚁群算法(MMACO)的任务调度方法.仿真实验表明:在网格环境下,该算法具有较好的全局最优求解能力和较快的收敛速度.

  11. AREVA announces US$ 7.75 Per share friendly cash offer for UraMin

    AREVA and UraMin Inc. ('UraMin') entered on June 15, 2007 into an agreement in respect of AREVA's friendly cash offer for 100% of the share capital of UraMin. UraMin is listed in London (AIM) and Toronto (TSX). AREVA (Euronext Paris) already owns 5.5% of UraMin's share capital. This cash offer of AREVA will be made through its indirect wholly-owned subsidiary CFMM Development ('AREVA') based on a price of US$ 7.75 per UraMin share. The total offer consideration amounts to more than USD 2.5 billion for 100% of the fully diluted share capital of UraMin. This represents a premium of 21% over UraMin 20-day weighted average trading price ending on June 8, 2007. The UraMin Board of Directors, after consulting with its financial advisors, has determined that the offer is fair and in the best interest of the UraMin shareholders and it has resolved to recommend acceptance of the Offer. BMO Capital Markets has provided an opinion that the offer is fair, from a financial point of view, to the UraMin shareholders. In connection with the offer, all directors and certain other shareholders representing approximately 25% of the outstanding UraMin shares (calculated on a fully diluted basis) have entered into lock-up agreements with AREVA pursuant to which they have agreed to tender all their UraMin shares to AREVA's offer. The support agreement entered into between AREVA and UraMin provides for, among other things, in case a superior proposal is accepted by UraMin, a right to match in favour of AREVA. The support agreement also includes a break up fee in favour of AREVA of US$ 75 million under certain circumstances. Concurrently with the closing of the proposed offer, UraMin will declare a dividend payable in shares of the capital of Niger Uranium Limited held by UraMin (where permitted by law) or a cash equivalent of the value of such shares

  12. Radiation-induced intestinal neoplasia in a genetically-predisposed mouse (Min)

    A mouse lineage with inherited predisposition to multiple intestinal neoplasia (min) has been proposed as a model to study human colorectal cancer. Min mice are heterozygous for the adenomatous polyposis coli (Apc) gene implicated in human familial adenomatous polyposis (FAP). There is an increased risk of intestinal cancer in humans following radiation exposure and the min mouse model may be used to further our understanding of the molecular mechanisms involved. The present study showed a 2 Gy dose of x-rays doubles the tumour numbers in the murine gastrointestinal tract of F1 min heterozygotes. The distribution of tumours through the gut was also recorded. (authors)

  13. Cloning and Sequence Analysis of Y-box Binding Protein Gene in Min Pig

    Zhang Dong-jie; Liu Di; Wang Liang; He Xin-miao; Wang Wen-tao

    2014-01-01

    In order to study the gene sequence of Min pig Y-box binding protein (YB-1) gene, the complete coding sequence of Min pig YB-1 gene was cloned by RT-PCR, the sequence features were analyzed by some software and online website. The results showed that the complete CDS of Min pig Y-box was found to be 975 bp long, encoding 324 amino acids. It contained a conserved cold shock domain and several phosphorylation sites, but had no transmembrane domains, and was consistent with a protein found in the cytoplasm. Min pig YB-1 nucleotides shared high similarity (61.37%-97.66%) with other mammals.

  14. MinCD Proteins Control the Septation Process during Sporulation of Bacillus subtilis

    Barák, Imrich; Prepiak, Peter; Schmeisser, Falko

    1998-01-01

    Mutation of the divIVB locus in Bacillus subtilis causes misplacement of the septum during cell division and allows the formation of anucleate minicells. The divIVB locus contains five open reading frames (ORFs). The last two ORFs (minCD) are homologous to minC and minD of Escherichia coli but a minE homolog is lacking in B. subtilis. There is some similarity between minicell formation and the asymmetric septation that normally occurs during sporulation in terms of polar septum localization. ...

  15. Quality control of the 113Sn-113mIn generator

    Methods for quality control of 113Sn-113mIn generators are compared and recommended the most convenient to applicate in hospitals and in more specialized quality control laboratories. The quality of 113Sn-113mIn generator produced by POLATOM (Poland) is also evaluated. The product met the requirements of the International Pharmacopeia

  16. Frequency drifts of 3-min oscillations in microwave and EUV emission above sunspots

    Sych, R; Nakariakov, V M; Anfinogentov, S A; Shibasaki, K; Yan, Y

    2011-01-01

    We analyse 3-min oscillations of microwave and EUV emission generated at different heights of a sunspot atmosphere, studying the amplitude and frequency modulation of the oscillations, and its relationship with the variation of the spatial structure of the oscillations. High-resolution data obtained with the Nobeyama Radioheliograph, TRACE and SDO/AIA are analysed with the use of the Pixelised Wavelet Filtering and wavelet skeleton techniques. 3-min oscillations in sunspots appear in the form of repetitive trains of the duration 8-20 min (13 min in average). The typical interval between the trains is 30-50 min. The oscillation trains are transient in frequency and power. We detected a repetitive frequency drifts of 3-min oscillations during the development of individual trains. Wavelet analysis shows three types of the frequency drift: positive, negative and fluctuations without drift. The start and end of the drifts coincide with the start time and end of the train. The comparative study of 3-min oscillation...

  17. Sustained Aftereffect of α-tACS Lasts Up to 70 min after Stimulation

    Kasten, Florian H.; Dowsett, James; Herrmann, Christoph S.

    2016-01-01

    Transcranial alternating current stimulation (tACS) has been repeatedly demonstrated to increase power of endogenous brain oscillations in the range of the stimulated frequency after stimulation. In the alpha band this aftereffect has been shown to persist for at least 30 min. However, in most experiments the aftereffect exceeded the duration of the measurement. Thus, it remains unclear how the effect develops beyond these 30 min and when it decays. The current study aimed to extend existing findings by monitoring the physiological aftereffect of tACS in the alpha range for an extended period of 90 min post-stimulation. To this end participants received either 20 min of tACS or sham stimulation with intensities below their individual sensation threshold at the individual alpha frequency (IAF). Electroencephalogram (EEG) was acquired during 3 min before and 90 min after stimulation. Subjects performed a visual vigilance task during the whole measurement. While the enhanced power in the individual alpha band did not return back to pre-stimulation baseline in the stimulation group, the difference between stimulation and sham diminishes after 70 min due to a natural alpha increase of the sham group. PMID:27252642

  18. Extensive metabolic disorders are present in APC(min) tumorigenesis mice.

    Liu, Zhenzhen; Xiao, Yi; Zhou, Zhengxiang; Mao, Xiaoxiao; Cai, Jinxing; Xiong, Lu; Liao, Chaonan; Huang, Fulian; Liu, Zehao; Ali Sheikh, Md Sayed; Plutzky, Jorge; Huang, He; Yang, Tianlun; Duan, Qiong

    2016-05-15

    Wnt signaling plays essential role in mesenchymal stem cell (MSC) differentiation. Activation of Wnt signaling suppresses adipogenesis, but promotes osteogenesis in MSC. Adenomatous polyposis coli (APC) is a negative regulator of β-catenin and Wnt signaling activity. The mutation of APC gene leads to the activation of Wnt signaling and is responsible for tumorigenesis in APC(min) mouse; however, very few studies focused on its metabolic abnormalities. The present study reports a widespread metabolic disorder phenotype in APC(min) mice. The old APC(min) mice have decreased body weight and impaired adipogenesis, but severe hyperlipidemia, which mimic the phenotypes of Familial Adenomatous Polyposis (FAP), an inherited disease also caused by APC gene mutation in human. We found that the expression of lipid metabolism and free fat acids (FA) use genes in the white adipose tissue (WAT) of the APC(min) mice is much lower than those of control. The changed gene expression pattern may lead to the disability of circulatory lipid transportation and storage at WAT. Moreover, the APC(min) mice could not maintain the core body temperature in cold condition. PET-CT determination revealed that the BAT of APC(min) mice has significantly impaired ability to take up (18)FDG from the blood. Morphological studies identified that the brown adipocytes of APC(min) mice were filled with lipid droplets but fewer mitochondria. These results matched with the findings of impaired BAT function in APC(min) mice. Collectively, our study explores a new mechanism that explains abnormal metabolism in APC(min) mice and provides insights into studying the metabolic disorders of FAP patients. PMID:26948948

  19. Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas.

    D Abaco, G. M.; Whitehead, R. H.; Burgess, A W

    1996-01-01

    Colon carcinomas appear to arise from the cumulative effect of mutations to several genes (APC, DCC, p53, ras, hMLH1, and hMSH2). By using novel colonic epithelial cell lines derived from the Immorto mouse, named the YAMC (young adult mouse colon) cell line, and an Immorto-Min mouse hybrid, named the IMCE (Immorto-Min colonic epithelial) cell line, carrying the Apc min mutation, we investigated the effect of an activated v-Ha-ras gene on tumor progression. The YAMC and IMCE cell lines are nor...

  20. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

    Moser, A R; Mattes, E M; Dove, W. F.; Lindstrom, M.J.; Haag, J D; Gould, M N

    1993-01-01

    ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors ...

  1. New cross section data and review of production routes of medically used $^{110m}$In

    Tárkányi, F; Ditrói, F; Hermanne, A; Baba, M; Mohsena, B M A; Ignatyuk, A V

    2016-01-01

    Evaluation of nuclear data for production routes of $^{110m}$In is in progress in the frame of an IAEA Coordinated Research Project (CRP). New experimental cross section data for the indirect $^{nat}$In(p,x)$^{110}$Sn $\\longrightarrow$ $^{110m}$In and for the direct $^{107}$Ag($\\alpha$,n)$^{110m}$In and $^{109}$Ag($^{3}$He,2n)$^{110m}$In production routes and for the satellite impurity reactions $^{107}$Ag($\\alpha$,xn)$^{110g,109}$In and $^{109}$Ag($^{3}$He,xn)$^{110g,111,109}$In have been measured by using the activation method, stacked foil irradiation technique and gamma-ray spectrometry. Additional data are reported for production of the $^{111}$In diagnostic gamma-emitter via the $^{109}$Ag($\\alpha$,2n)$^{111}$In reaction. The earlier experimental data were critically reviewed in order to prepare recommended data and optimal production parameters for the different routes.

  2. 2.5-min Isostatic Gravity Grid for the United States

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2.5-min isostatic gravity data set was produced by regridding the 4-km residual isostatic gravity grid of the U.S. The isostatic residual gravity grid was...

  3. MSL Chemistry and Mineralogy X-Ray Diffraction X-Ray Fluorescence (CheMin) Instrument

    Zimmerman, Wayne; Blake, Dave; Harris, William; Morookian, John Michael; Randall, Dave; Reder, Leonard J.; Sarrazin, Phillipe

    2013-01-01

    This paper provides an overview of the Mars Science Laboratory (MSL) Chemistry and Mineralogy Xray Diffraction (XRD), X-ray Fluorescence (XRF) (CheMin) Instrument, an element of the landed Curiosity rover payload, which landed on Mars in August of 2012. The scientific goal of the MSL mission is to explore and quantitatively assess regions in Gale Crater as a potential habitat for life - past or present. The CheMin instrument will receive Martian rock and soil samples from the MSL Sample Acquisition/Sample Processing and Handling (SA/SPaH) system, and process it utilizing X-Ray spectroscopy methods to determine mineral composition. The Chemin instrument will analyze Martian soil and rocks to enable scientists to investigate geophysical processes occurring on Mars. The CheMin science objectives and proposed surface operations are described along with the CheMin hardware with an emphasis on the system engineering challenges associated with developing such a complex instrument.

  4. Berberine Inhibits Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage Polarization

    Piao, Meiyu; Cao, Hailong; He, Nana; Yang, Boli; Dong, Wenxiao; Xu, Mengque; Yan, Fang; Zhou, Bing; Wang, Bangmao

    2016-01-01

    Antitumor effect of berberine has been reported in a wide spectrum of cancer, however, the mechanisms of which are not fully understood. The aim of this study was to investigate the hypothesis that berberine suppresses tumorigenesis in the familial adenomatous polyposis (FAP) by regulating the macrophage polarization in Apc (min/+) mouse model. Berberine was given to Apc (min/+) mice for 12 weeks. Primary macrophages were isolated; after berberine treatment, the change in signaling cascade wa...

  5. Rainfall Prediction using Data-Core Based Fuzzy Min-Max Neural Network for Classification

    Rajendra Palange,; Nishikant Pachpute

    2015-01-01

    This paper proposes the Rainfall Prediction System by using classification technique. The advanced and modified neural network called Data Core Based Fuzzy Min Max Neural Network (DCFMNN) is used for pattern classification. This classification method is applied to predict Rainfall. The neural network called fuzzy min max neural network (FMNN) that creates hyperboxes for classification and predication, has a problem of overlapping neurons that resoled in DCFMNN to give greater accu...

  6. On the gauge-invariant operator $A^2_{\\min}$ in Euclidean Yang-Mills theories

    Capri, M A L; Guimaraes, M S; Mintz, B W; Palhares, L F; Sorella, S P

    2016-01-01

    We review our recent work on the gauge-invariant non-local dimension-two operator $A^2_{\\rm min}$, whose minimization is defined along the gauge orbit. Albeit non-local, the operator $A^2_{\\rm min}$ can be cast in local form through the introduction of an auxiliary Stueckelberg field. The whole procedure results into a local action which turns out to be renormalizable to all orders.

  7. Min-Min任务调度算法的研究与仿真

    朱雷

    2016-01-01

    文章首先对Min-Min算法进行分析,介绍了算法的思想和执行过程.然后使用GridSim模拟器对算法模拟实现,给出了算法的JAVA实现代码,并统计了Min-Min算法实验结果的完成时间.

  8. Frequency drifts of 3-min oscillations in microwave and EUV emission above sunspots

    Sych, R.; Zaqarashvili, T. V.; Nakariakov, V.M.; Anfinogentov, S. A.; Shibasaki, K; Yan, Y.

    2011-01-01

    We analyse 3-min oscillations of microwave and EUV emission generated at different heights of a sunspot atmosphere, studying the amplitude and frequency modulation of the oscillations, and its relationship with the variation of the spatial structure of the oscillations. High-resolution data obtained with the Nobeyama Radioheliograph, TRACE and SDO/AIA are analysed with the use of the Pixelised Wavelet Filtering and wavelet skeleton techniques. 3-min oscillations in sunspots appear in the form...

  9. Failure of caffeine to affect metabolism during 60 min submaximal exercise.

    Titlow, L W; Ishee, J H; Riggs, C E

    1991-01-01

    Caffeine consumption prior to athletic performance has become commonplace. The usual dosage is approximately 200 mg, a level of caffeine ingestion equivalent to two cups of brewed coffee. This study was designed to examine the effects of a common level of caffeine ingestion, specifically 200 mg, on metabolism during submaximal exercise performance in five males. The subjects performed two 60-min monitored treadmill workouts at 60% maximal heart rate during a 2-week period. The subjects were randomly assigned, double-blind to receive a caffeine or placebo capsule 60 min prior to exercise. Testing was performed in the afternoon following a midnight fast. Venous blood was withdrawn pre-exercise, every 15 min during the workout, and 10 min after recovery. Blood was analysed for free fatty acid, triglycerides, glucose, lactic acid, haemoglobin and haematocrit. The respiratory exchange ratio (R), perceived exertion (RPE) and oxygen uptake were measured every 4 min during exercise. An examination of the data with repeated-measures ANOVA revealed no significant differences between the two groups. Within the limitations of the study, it was concluded that 200 mg caffeine failed to affect metabolism during 60 min submaximal exercise. PMID:1856908

  10. Global statistical maps of extreme-event magnetic observatory 1 min first differences in horizontal intensity

    Love, Jeffrey J.; Coïsson, Pierdavide; Pulkkinen, Antti

    2016-05-01

    Analysis is made of the long-term statistics of three different measures of ground level, storm time geomagnetic activity: instantaneous 1 min first differences in horizontal intensity ΔBh, the root-mean-square of 10 consecutive 1 min differences S, and the ramp change R over 10 min. Geomagnetic latitude maps of the cumulative exceedances of these three quantities are constructed, giving the threshold (nT/min) for which activity within a 24 h period can be expected to occur once per year, decade, and century. Specifically, at geomagnetic 55°, we estimate once-per-century ΔBh, S, and R exceedances and a site-to-site, proportional, 1 standard deviation range [1 σ, lower and upper] to be, respectively, 1000, [690, 1450]; 500, [350, 720]; and 200, [140, 280] nT/min. At 40°, we estimate once-per-century ΔBh, S, and R exceedances and 1 σ values to be 200, [140, 290]; 100, [70, 140]; and 40, [30, 60] nT/min.

  11. Purification and Crystallization of MinCD Complex from Escherichia coli%大肠杆菌MinCD蛋白复合物纯化方法和晶体筛选

    金瑾; 杨少媛; 朱嘉; 雷振; 郑积敏; 贾宗超

    2015-01-01

    大肠杆菌在细胞分裂时,细胞中部潜在分裂位点的选择受到Min系统(MinC、MinD和MinE蛋白)的精确调控,其中MinC与MinD可以形成复合物以抑制Z分裂环在错误的位置形成.本研究采用基因克隆方法获得minC、minD基因的克隆,并表达得到MinC和MinD的重组蛋白,用亲和层析与凝胶过滤层析对所得蛋白进行纯化,通过minC、minD分别单独转化、表达纯化后混合和minC、minD共转化法两种方法得到MinCD蛋白复合物,并分别对其进行晶体筛选.结果表明,共转化法得到的MinCD复合物纯度较好,且比例约为2∶1,通过晶体筛选初步获得针状蛋白晶体,为MinCD复合物的结构解析提供了实验基础.

  12. Nuclear model calculation and targetry recipe for production of 110mIn

    110mIn is potentially an important positron emitting that can be used in positron emission tomography. In this work, the excitation functions and production yields of 110Cd(d, 2n), 111Cd(d, 3n), natCd(d, xn), 110Cd(p, n), 111Cd(p, 2n), 112Cd(p, 3n) and natCd(p, xn) reactions to produce the 110mIn were calculated using nuclear model code TALYS and compared with the experimental data. The yield of isomeric state production of 110In was also compared with ground state production ones to reach the optimal energy range of projectile for the high yield production of metastable state. The results indicate that the 110Cd(p, n)110mIn is a high yield reaction with an isomeric ratio (σm/σg) of about 35 within the optimal incident energy range of 15–5 MeV. To make the target, cadmium was electroplated on a copper substrate in varying electroplating conditions such as PH, DC current density, temperature and time. A set of cold tests were also performed on the final sample under several thermal shocks to verify target resistance. The best electroplated cadmium target was irradiated with 15 MeV protons at current of 100 µA for one hour and the production yield of 110mIn and other byproducts were measured. - Highlights: • Optimization of a cadmium electroplating bath to produce high yield 110mIn. • Influence of targetry on isomeric cross section ratio 110mIn/110gIn. • Activity measurement for natCd(p, xn)110m,110g,111g,114mIn reactions

  13. Preliminary results of a computer-assisted vocal load test with 10-min test duration.

    Hanschmann, Holger; Gaipl, Christoph; Berger, Roswitha

    2011-02-01

    Nowadays, many occupations require a high vocal loading capacity. Therefore, it becomes increasingly important to have suitable test procedures for the vocal load, which can be executed with a low personnel and temporal expenditure. Patients with decreased vocal loading capacity were distinguished from test persons free of voice complaints with a 15-min test. It should be examined whether the test duration can be further shortened by an increase in the demanded vocal intensity. Sixty two persons underwent a vocal load test (VLT) of 10 min: in each case, 1 min in the volumes 75 dB(A) and 80 dB(A). Volume and fundamental frequency were measured real time. Before and directly after vocal load, as well as after a 30-min voice rest, the Goettingen hoarseness diagram was executed for the objective judgment of vocal quality. Besides, every person assessed himself on the bases of the Voice Handicap Index (VHI 12) and a questionnaire on the subjective state before the examination and after the VLT. The test could be mastered by all participants, patients and test persons, and was evaluated by all as tiring. However, we could not distinguish persons who indicated a decreased vocal maximum stress in everyday life from persons without vocal complaints using the shorter test with higher load, which was possible in the 15-min test pattern. A shortening of the test duration to 10 min for an examination of the vocal loading capacity is not possible, in spite of raised vocal load. It was proved in this study that a reliable distinction between patients and test persons was not possible using the 10-min vocal load test. A reliable statement concerning the permanent capacity of the voice cannot be made. Further scientific investigation in the important field of vocal load diagnostics is required. PMID:21107853

  14. Rain rate modeling of 1-min from various integration times in South Korea.

    Shrestha, Sujan; Park, Jung-Jin; Choi, Dong-You

    2016-01-01

    Rain plays a major impairment factor for propagation of electromagnetic waves in atmosphere for systems operating at frequencies above 10 GHz. Several effects are noted such as depolarization, scintillation, interference due to scattering and extra attenuation which seems to increase with frequency. To mitigate its effect in satellite communication, knowledge of local rainfall statistics is necessary which act as milestone for design of radio link. Rain attenuation is best visualize by the 1-min rainfall rate statistic but the measurement of this rain rate distribution is rare on a worldwide basis and observation of rain rate are done with longer integration times typically 30 min or more. In this paper, efforts have been made to develop model that can convert rain rate complementary cumulative distribution function to shorter integration times. The average relative error margin of about 5, 14, 43, 71 and 115 % are noted for 5 to 1-, 10 to 1-, 20 to 1, 30 to 1- and 60 to 1-min respectively from ITU-R P.837-6 method which have been analyzed in further section of this article. The empirical natures of conversion methods as such Segal method, Burgueno's method, Chebil and Rahman method and Logarithmic model are studied along with the proposed new model that seems to be applicable in derivation of 1-min rain rate of the South Korea rain rate statistics. International Telecommunication Union-Radio communication Sector (ITU-R) has developed a recommendation ITU-R P.837-6 that enables the user to estimate the local 1-min rainfall rate statistical distribution which is compared with calculated 1-min rain rate distribution from experimental 1-min rainfall accumulation. Unfortunately, ITU-R P.837-6 estimated 1-min values show greater error percentages. In order to get better approximation of local 1-min rain rate estimation, a novel method is proposed and it's efficiency have been compared with rainfall rate statistics obtained from nine different locations in the South

  15. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island.

    Ashton, Philip M; Nair, Satheesh; Dallman, Tim; Rubino, Salvatore; Rabsch, Wolfgang; Mwaigwisya, Solomon; Wain, John; O'Grady, Justin

    2015-03-01

    Short-read, high-throughput sequencing technology cannot identify the chromosomal position of repetitive insertion sequences that typically flank horizontally acquired genes such as bacterial virulence genes and antibiotic resistance genes. The MinION nanopore sequencer can produce long sequencing reads on a device similar in size to a USB memory stick. Here we apply a MinION sequencer to resolve the structure and chromosomal insertion site of a composite antibiotic resistance island in Salmonella Typhi Haplotype 58. Nanopore sequencing data from a single 18-h run was used to create a scaffold for an assembly generated from short-read Illumina data. Our results demonstrate the potential of the MinION device in clinical laboratories to fully characterize the epidemic spread of bacterial pathogens. PMID:25485618

  16. Remote Stimulated Triggering of Quantum Entangled Nuclear Metastable States of 115mIn

    Van Gent, D L

    2004-01-01

    We report experiments in which two indium foils were quantum entangled via photoexcitation of stable 115In to radioactive 115mIn by utilizing Bremsstrahlung gamma photons produced by a Varian Compact Linear Accelerator (CLINAC). After photo-excitation, remote triggering of the "master" foil with low energy gamma photons, yielded stimulated emissions of 336 keV gamma photons from quantum entangled 115mIn in the "slave" foil located up to 1600 m away from the "master" foil. These experiments strongly demonstrate that useful quantum information can be transferred through quantum channels via modulation of quantum noise (accelerated radioactive decay of 115mIn metastable nuclei). Thus, this modality of QE transmission is fundamentally different from optical QE information transfer via quantum entangled space "q-bits" as developed by information theorists for quantum channel information transfer. Additionally, there is no obvious potential for signal degradation with increasing distance nor the problems associated...

  17. Lavoisier, sa collection et l'Atlas et description minéralogique de la France

    Pelucchi, Stéphane

    2011-01-01

    La collection géologique de Lavoisier, conservée au muséum Henri-Lecoq de Clermont- Ferrand, est intimement liée au projet de publication de l'Atlas minéralogique de la France par Jean-Étienne Guettard. Choisi, pour ses qualités, comme collaborateur, Antoine-Laurent de Lavoisier, seul ou accompagnant Guettard, multiplie entre 1763 et 1768 les courses géologiques à travers le quart nord-est de la France et autour de Paris. Il accumule ainsi plusieurs milliers de spécimens minéralogiques et obs...

  18. Päiväkodin liikuntakasvatus lapsen minäkäsityksen ja itsetunnon tukemisessa

    Satoniitty, Sanna

    2010-01-01

    Tämän opinnäytetyön aiheena oli tutkia päiväkodin liikuntakasvatusta sosiaalialan ja sosiaalipedagogiikan näkökulmasta. Tutkimustehtävänä oli selvittää, pyritäänkö päiväkodin liikuntakasvatuksella tukemaan lapsen positiivista minäkäsitystä ja itsetuntoa, sekä millainen liikuntakasvatus tukee lapsen positiivista minäkäsitystä ja itsetuntoa parhaiten. Tutkimus oli luonteeltaan kvalitatiivinen ja se toteutettiin lomakekyselyllä Porin kaupungin päiväkodeille lokakuussa 2009. Tutkimuksen teore...

  19. Laypersons may learn basic life support in 24min using a personal resuscitation manikin

    Isbye, Dan Lou; Rasmussen, Lars Simon; Lippert, Freddy Knudsen;

    2006-01-01

    challenge is to find the most efficient one. AIMS: To compare the efficiency of a 24 min instruction using a DVD-based self-training BLS course combined with a simple, take-home resuscitation manikin to a conventional 6h course for teaching BLS to laypersons. METHODS: In total, 238 laypersons (age 21......: When assessed after 3 months, a 24 min DVD-based instruction plus subsequent self-training in BLS appears equally effective compared to a 6h BLS course and hence is more efficient. Udgivelsesdato: 2006-Jun...

  20. AtMIN7 mediated disease resistance to Pseudomonas syringae in Arabidopsis

    He, Sheng Yang; Nomura, Kinya

    2011-07-26

    The present invention relates to compositions and methods for enhancing plant defenses against pathogens. More particularly, the invention relates to enhancing plant immunity against bacterial pathogens, wherein AtMIN7 mediated protection is enhanced and/or there is a decrease in activity of an AtMIN7 associated virulence protein such as a Pseudomonas syringae pv. tomato DC3000 HopM1. Reagents of the present invention provide a means of studying cellular trafficking while formulations of the present inventions provide increased pathogen resistance in plants.

  1. Mission Overview of the Miniature X-ray Solar Spectrometer (MinXSS) CubeSat

    Woods, Thomas N.; Caspi, Amir; Chamberlin, Phillip C.; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Mason, James; Moore, Christopher; Palo, Scott; Rouleau, Colden; Solomon, Stanley

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat to study the energy distribution of solar flare soft X-ray (SXR) emissions of the quiet Sun, active regions, and during flares and to model the solar SXR impact in Earth’s ionosphere, thermosphere, and mesosphere (ITM) using these MinXSS solar measurements. The energy variability in the SXR range can vary by more than a factor of 100, yet we have limited spectral measurements in the SXR to accurately quantify the spectral dependence of this variability. Energy from SXR radiation is deposited mostly in the ionospheric E-region, from ~80 to ~150 km, but the precise altitude is strongly dependent on the SXR spectrum because of the steep slope and structure of the photoionization cross sections of atmospheric gases in this wavelength range. The new MinXSS solar SXR spectra measurements and associated modeling of the solar spectra and Earth’s ITM response will address these outstanding issues. MinXSS includes an Amptek X123 X-ray spectrometer to measure solar irradiance spectra from 0.5 – 30 keV [2.5– 0.04 nm] with a nominal 0.15 keV energy resolution [spectral resolution of 0.7 nm at 2.5 nm and 0.0002 nm at 0.04 nm] and a SXR photometer with similar spectral sensitivity. Both of these SXR instruments had pre-flight calibrations with an accuracy of about 5% at the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF). This presentation will include an overview of the MinXSS CubeSat design and development that involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. The MinXSS CubeSat was launched in December 2015 to the International Space Station (ISS) and awaits deployment from the ISS in April-May 2016. Assuming MinXSS has been deployed before June, we also intend to present first light observations from MinXSS to highlight solar SXR spectra and SXR variability during May 2016.

  2. Climate change and the irreversibility effect: combining expected utility and MaxiMin

    Lange, Andreas

    2002-01-01

    This paper analyzes decisions on emissions of a stock pollutant under uncertainty in a two period model. Decisions are based on a weighted average of expected utility (EU) and the MaxiMin criterion. I first show that more weight on the worst case (less weight on EU) may lead to increased first period emissions. The effect of learning possibilities on emissions is not clear in general, but depends qualitatively on the weight given to MaxiMin: For the quadratic utility case, considering prospec...

  3. Climate Change and the Irreversibility Effect – Combining Expected Utility and MaxiMin

    Lange, Andreas

    2002-01-01

    This paper analyzes decisions on emissions of a stock pollutant under uncertainty in a two period model. Decisions are based on a weighted average of expected utility (EU) and the MaxiMin criterion. I first show that more weight on the worst case (less weight on EU) may lead to increased first period emissions. The effect of learning possibilities on emissions is not clear in general, but depends qualitatively on the weight given to MaxiMin: For the quadratic utility case, considering prospec...

  4. Determination of Glomerular Filtration Rate with 51Cr, 58Co, 114mIn, 115mIn and 169Yb- Labelled EDTA and DTPA Complexes

    Some metal complexes are suitable for determination of the glomerular filtration rate (GFR). A series of labelled EDTA and DTPA complexes have been produced during the last two years by the Isotope Institute of the Hungarian Academy of Sciences. The common property of EDTA and DTPA complexes is their great stability, which is a major advantage over the iodinated compounds. We have demonstrated that none of the complexes used by us combine with plasma proteins or penetrate into the red blood cells. There is evidence that EDTA and DTPA leave the body exclusively by way of glomerular filtration. The results of more than 600 cases are presented. 169Yb EDTA was used in 315, 51Cr EDTA in 126, 114mIn EDTA in 83, 58Co DTPA in 72 and 115mIn EDTA in 28 cases for determination of GFR. The injected activity was 0.3 -4.0 μCi/kg body weight. In most cases the result has been compared with the 24-h endogenous creatine clearance, and in 50 cases with inulin clearance also. In general the single-shot method was used. Blood samples were taken about the first and the second hour after injection of the isotope. A formula is given for calculating GFR. In a few cases we administered the isotope in the same way as inulin (priming dose and constant plasma concentration sustained by an infusion pump). Our results show that the single-shot method is a very suitable one in routine clinical practice either in states of normal or reduced kidney function. Using the single-shot method for GFR determination is especially important in those cases where the collection of urine is impossible without using a catheter, which always entails the risk of infection. Results are reliable even in disorders of the urinary tract. During or after the procedure no side effects could be observed. (author)

  5. Minásbate Equivalents of Mathematical Concepts: Their Socio-Cultural Undertones

    Balbuena, Sherwin E.; Cantoria, Uranus E.; Cantoria, Amancio L., Jr.; Ferriol, Eny B.

    2015-01-01

    This paper presents the collection and analysis of Minásbate equivalents of some concepts used in the study of arithmetic, counting, and geometry as provided by the elderly residents of the province of Masbate. The glossary of mathematical terms derived from interviews would serve as an authoritative reference for mother tongue teachers in the…

  6. CO2 laser welding of aluminum alloys at high speeds up to 20 m/min

    Takahashi, Kunimitsu; Kumagai, Mikio; Katayama, Seiji; Matsunawa, Akira

    2003-03-01

    CO2 laser welding of thin aluminum sheets was performed at welding speeds of up to 20 m/min to investigate the weldability, weld pool dynamics and mechanical properties of the weld bead of aluminum alloys. High-speed camera observation of weld areas showed that the thickness of the keyhole-front-face decreased to 100 μm under high-speed welding conditions and the weld pool became unstable. The focal length was optimized to increase the spot power density and thereby easily melt the aluminum sheets. Using a 76-mm focal length lens, which corresponds to 11 MW/cm2 power density, we obtained a keyhole mode weld bead with a depth of 1.3 mm at 20 m/min welding speed at 2 kW laser power. It was also possible to reduce the heat affected zone (HAZ) width to only 1.6 mm when the welding speed was 20 m/min. The HAZ width decreased as welding speed was increased. The tensile strength test of A6N01 weld beads showed that the fracture strength increased as the welding speed was increased up to 16 m/min, probably because the soft region of weld specimens was decreased. On the other hand, solidification cracks formed in the weld bead center at higher speeds, resulting in decreased strength.

  7. Numerical Analysis of Strongly Nonlinear Oscillation Systems using He's Max-Min Method

    Babazadeh, H; Domairry, G; Barari, Amin;

    2011-01-01

    Nonlinear functions are crucial points and terms in engineering problems. Actual and physical problems can be solved by solving and processing such functions. Thus, most scientists and engineers focus on solving these equations. This paper presents a novel method called the max-min method...

  8. Reliability of the 6-min walk test after total knee arthroplasty

    Jakobsen, Thomas Linding; Kehlet, Henrik; Bandholm, Thomas

    2013-01-01

    min. The reliability is unknown in patients with TKA. Therefore, the purpose of the study was to assess the reliability of the 6-min walk test in patients with recent TKA. METHODS: Thirty-four patients with TKA performed 2 test trials the same day, separated by a 1-h seated rest. To assess...... reliability, intra-class correlation coefficient (ICC(2,1)), standard error of measurement (SEM), and smallest real difference (SRD) were calculated. RESULTS: The patients walked on average 14.1 m longer at the second (397.2 m) compared to the first (383.1 m) test trial. The ICC(2,1), SEM, and SRD were 0.......97, 13.0, and 36.1 m, respectively. CONCLUSIONS: The intra-tester reliability of the 6-min walk test was high in patients with TKA. The thresholds of the 6-min walk test to detect a real change are acceptable in research (SEM) and clinical settings (SRD). We recommend that the longest distance walked in...

  9. Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort

    Spruit, Martijn A; Watkins, Michael L; Edwards, Lisa D; Vestbo, Jørgen; Calverley, Peter M A; Pinto-Plata, Victor; Celli, Bartolome R; Tal-Singer, Ruth; Wouters, Emiel F M; NN, NN

    2010-01-01

    BACKGROUND: The 6-min walking test (6MWT) is widely used to assess exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). Given the prognostic significance of the 6MWT, it is important to identify why some COPD patients perform poorly in terms of this outcome. We aimed to...

  10. Separation of sup(115m)In from mother 115Cd

    The methods of the accelerated isolation of the metallic sup(115m)In from the mother solution of 115Cd were worked out. The sample was dissolved in the concentrated HCl with the presence of H2O2. After the injection of 5 mg (recalculated for the metallic In) of the carrier, the solution was evaporated dry, the remainder was dissolved in 2n HCl. The obtained solution was lead through an ion-exchange column (9 mm in diameter and with the 250 mm height of the layer with the anionite Dowex 2x8 (50-100 mesh). The sup(115m)In was eluated by 0.15n HCl, and 115Cd - by 1.5n HCl. Radiochemical purity of the sup(115m)In was not less than 99.99%. The isolation of the sup(115m)In from the eluent (alkalined up to ph=2.3) was carried out electrochemically during approximately 1 hour on the platinum cathode at high (400 mA/cm2) cathode density of current

  11. Symmetry and scale orient Min protein patterns in shaped bacterial sculptures

    Wu, Fabai; van Schie, Bas G. C.; Keymer, Juan E.; Dekker, Cees

    2015-08-01

    The boundary of a cell defines the shape and scale of its subcellular organization. However, the effects of the cell's spatial boundaries as well as the geometry sensing and scale adaptation of intracellular molecular networks remain largely unexplored. Here, we show that living bacterial cells can be ‘sculpted’ into defined shapes, such as squares and rectangles, which are used to explore the spatial adaptation of Min proteins that oscillate pole-to-pole in rod-shaped Escherichia coli to assist cell division. In a wide geometric parameter space, ranging from 2 × 1 × 1 to 11 × 6 × 1 μm3, Min proteins exhibit versatile oscillation patterns, sustaining rotational, longitudinal, diagonal, stripe and even transversal modes. These patterns are found to directly capture the symmetry and scale of the cell boundary, and the Min concentration gradients scale with the cell size within a characteristic length range of 3-6 μm. Numerical simulations reveal that local microscopic Turing kinetics of Min proteins can yield global symmetry selection, gradient scaling and an adaptive range, when and only when facilitated by the three-dimensional confinement of the cell boundary. These findings cannot be explained by previous geometry-sensing models based on the longest distance, membrane area or curvature, and reveal that spatial boundaries can facilitate simple molecular interactions to result in far more versatile functions than previously understood.

  12. A hypothesis to explain division site selection in Escherichia coli by combining nucleoid occlusion and Min.

    Norris, Vic; Woldringh, Conrad; Mileykovskaya, Eugenia

    2004-03-12

    The positioning of the site of cell division in Escherichia coli results, it is generally believed, from the operation of nucleoid occlusion in combination with the Min system. Nucleoid occlusion prevents division over the nucleoids and directs it by default to the mid-cell region between segregating nucleoids or to polar regions while the Min system prevents division in polar regions. Unresolved questions include how these systems interact to control the earliest known event in division, the assembly at the membrane of the tubulin-like protein, FtsZ, and, more importantly, what exactly constitutes a division site. Evidence exists that (1) the coupled transcription, translation and insertion of proteins into membrane (transertion), can structure the cytoplasmic membrane into phospholipid domains, (2) the MinD protein can convert vesicles into tubes and (3) a variety of membranous structures can be observed at mid-cell. These data support a model in which transertion from the segregating daughter chromosomes leads to the formation of a distinct proteolipid domain between them at mid-cell; the composition of this domain allows phospholipid tubes to extend like fingers into the cytoplasm; these tubes then become the substrate for the dynamic assembly and disassembly of FtsZ which converts them into the invaginating fold responsible for division; the Min system inhibits division at unwanted sites and times by removing these tubes especially at the cell poles. PMID:15013745

  13. A New World: Redefining the Legacy of Min-Zhan Lu

    Ray, Brian

    2008-01-01

    This article discusses exchanges between a number of scholars during the 1990s centering on Min-Zhan Lu's controversial essay "Conflict and Struggle: The Enemies or Preconditions of Basic Writing?" In some ways, "Conflict and Struggle" blazed a trail for later work in "hybrid" or "mixed" forms of academic writing while at the same time igniting…

  14. Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort

    Spruit, Martijn A; Watkins, Michael L; Edwards, Lisa D;

    2010-01-01

    identify clinical determinants of a poor 6-min walking distance (<350 m) in patients with COPD. METHODS: 1795 individuals with a diagnosis of COPD underwent spirometry; bio-electrical impedance analysis; low-dose computed tomography scans of the chest; 6MWT; ATS-DLD co-morbidity questionnaire; Center for...

  15. Climate Change and the Irreversibility Effect. Combining Expected Utility and MaxiMin

    Lange, A. [Centre for European Economic Research (ZEW), P.O.Box 103443, D-68034 Mannheim (Germany)

    2003-08-01

    This paper analyzes decisions on emissions of a stock pollutant under uncertainty in a two period model. Decisions are based on a weighted average of expected utility (EU) and the MaxiMin criterion. I first show that more weight on the worst case (less weight on EU) may lead to increased first period emissions. The effect of learning possibilities on emissions is not clear in general, but depends qualitatively on the weight given to MaxiMin: For the quadratic utility case, considering prospective learning increases today's abatement effort, i.e. the ``irreversibility effect'' holds, if the weight on EU is small. This contrasts standard results on the irreversibility effect for EU which translates to small weights on MaxiMin. There is, however, the possibility of a negative value of learning. It is shown that the irreversibility effect holds if and only if the value of learning is negative. Consequences for the applicability of generalized EU-MaxiMin are discussed.

  16. Nuclear model calculation and targetry recipe for production of 110mIn.

    Kakavand, T; Mirzaii, M; Eslami, M; Karimi, A

    2015-10-01

    (110m)In is potentially an important positron emitting that can be used in positron emission tomography. In this work, the excitation functions and production yields of (110)Cd(d, 2n), (111)Cd(d, 3n), (nat)Cd(d, xn), (110)Cd(p, n), (111)Cd(p, 2n), (112)Cd(p, 3n) and (nat)Cd(p, xn) reactions to produce the (110m)In were calculated using nuclear model code TALYS and compared with the experimental data. The yield of isomeric state production of (110)In was also compared with ground state production ones to reach the optimal energy range of projectile for the high yield production of metastable state. The results indicate that the (110)Cd(p, n)(110m)In is a high yield reaction with an isomeric ratio (σ(m)/σ(g)) of about 35 within the optimal incident energy range of 15-5 MeV. To make the target, cadmium was electroplated on a copper substrate in varying electroplating conditions such as PH, DC current density, temperature and time. A set of cold tests were also performed on the final sample under several thermal shocks to verify target resistance. The best electroplated cadmium target was irradiated with 15 MeV protons at current of 100 µA for one hour and the production yield of (110m)In and other byproducts were measured. PMID:26141297

  17. Development of a colour scale for colour evaluation of beef carcasses at 60 min post mortem

    Hulsegge, I.; Merkus, G.S.M.

    1999-01-01

    The pectoralis profundus muscles of 200 selected beef carcasses were measured to develop a standard colour scale for evaluating beef carcasses at the time of classification (approximately 60 min post mortem). Five lightness (L*) values were chosen ranging from 22 to 42 with intervals of five L* unit

  18. The Aggregate Homotopy Method for Multi-objective Max-min Problems

    He Li

    2011-03-01

    Full Text Available Multi-objective programming problem was transformed into a class of simple unsmooth single-objective programming problem by Max-min ways. After smoothing with aggregate function, a new homotopy mapping was constructed. The minimal weak efficient solution of the multi-objective optimization problem was obtained by path tracking. Numerical simulation confirmed the viability of this method.

  19. Minimum Cycle Basis and All-Pairs Min Cut of a Planar Graph in Subquadratic Time

    Wulff-Nilsen, Christian

    2009-01-01

    algorithm, we obtain the fol- lowing result: with O(n3/2 log n) time and O(n3/2) space for prepro- cessing, the weight of a min cut between any two given vertices of G can be reported in constant time. Previously, such an oracle required quadratic time and space for preprocessing. The oracle can also be...

  20. Identification of 158Yb, Tsub(1/2)=1.1+-0.2 min

    On the basis of the analysis of the gamma-spectrum of A = 158 isobars the 158Yb isotope has been identified. Its half-life Tsub(1/2)=1.1+-0.2 min. has been measured. The 158Y decay is followed by emission of 74.2+-0.2 keV gamma-ray. (author)

  1. Ja jos minä menisin naapuriin (2/4 F)

    2011-01-01

    Laulun sanat: Ja jos minä menisin naapuriin, sun tuutima lullanlei, kyll' saisin sieltä mä tyttären, sun tuutima lullanlei, ja ois se niin helkkarin komea, sun tuutima lullanlei, sen kotia veisin oriilla, sun tuutima lullanlei!

  2. The effect of soy isoflavones on the development of intestinal neoplasia in Apc(Min) mouse

    Sørensen, Ilona Kryspin; Kristiansen, Eva; Mortensen, Alicja; Nicolaisen, G.M.; Wijnandes, J.A.H.; van Kranen, H.J.; van Kreijl, C.F.

    Data from epidemiological studies suggest that isoflavones in soy may have a protective effect on the development of colon cancer in humans. Therefore, we have investigated whether soy isoflavones will inhibit intestinal tumour development in Apc(Min) mice. The mice were fed a Western-type high r...

  3. ApcMin, A Mutation in the Murine Apc Gene, Predisposes to Mammary Carcinomas and Focal Alveolar Hyperplasias

    Moser, Amy Rapaich; Mattes, Ellen M.; Dove, William F.; Lindstrom, Mary J.; Haag, Jill D.; Gould, Michael N.

    1993-10-01

    ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.

  4. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

    Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D2) caused more adenomas in ApcMin/+ mice. Conversely, highly expressed transgenic HPGDS allowed fewer tumors. Prostaglandin D2 (PGD2) binds to the prostaglandin D2 receptor known as PTGDR (or DP1). PGD2 metabolites bind to peroxisome proliferator-activated receptor γ (PPARG). We hypothesized that Ptgdr or Pparg knockouts may raise numbers of tumors, if these receptors take part in tumor suppression by PGD2. To assess, we produced ApcMin/+ mice with and without Ptgdr knockouts (147 mice). In separate experiments, we produced ApcMin/+ mice expressing transgenic lipocalin-type prostaglandin D synthase (PTGDS), with and without heterozygous Pparg knockouts (104 mice). Homozygous Ptgdr knockouts raised total numbers of tumors by 30–40% at 6 and 14 weeks. Colon tumors were not affected. Heterozygous Pparg knockouts alone did not affect tumor numbers in ApcMin/+ mice. As mentioned above, our Pparg knockout assessment also included mice with highly expressed PTGDS transgenes. ApcMin/+ mice with transgenic PTGDS had fewer large adenomas (63% of control) and lower levels of v-myc avian myelocytomatosis viral oncogene homolog (MYC) mRNA in the colon. Heterozygous Pparg knockouts appeared to blunt the tumor-suppressing effect of transgenic PTGDS. However, tumor suppression by PGD2 was more clearly mediated by receptor PTGDR in our experiments. The suppression mechanism did not appear to involve changes in microvessel density or slower proliferation of tumor cells. The data support a role for PGD2 signals acting through PTGDR in suppression of intestinal tumors

  5. Nuclear decay scheme studies of 30-h 131Te/sup m/, 25-min 131Te/sup g/, and 55.5-min 105Cd

    High-resolution Ge(Li) detectors have been used to observe γ-ray singles and coincidence spectra of 30-h 11/2-, /sup 131m/Te, 25-min 3/2+, and 55.5-min 5/2+105Cd. Sources of /sup 131m/Te and /sup 131g/Te were produced by neutron irradiation of enriched 130Te metal, and, in the case of /sup 131m/Te, were chemically purified to remove the 131I daughter. A total of 190 and 80 γ-rays are attributed to the decays of /sup 131m/Te and /sup 131g/Te, respectively; and 174 and 77 of these transitions have been placed in a 131I level scheme involving 52 excited states. Absolute β group intensities were determined for the transitions to 131I levels. Spin and parity assignments were made for all observed levels. The β feeding from the 11/2- /sup 131m/Te to the 7/2+131I ground state was determined to be (5.2 +- 3.0) percent (log ft = 10.5). The isomeric transition of 11/2- /sup 131m/Te to 3/2+ /sup 131g/Te was determined to be (22.2 +- 1.6) percent. The 6-nsec isomer in 131I at 1797 keV has been assigned as 15/2- and interpreted as a πν1ν2 three quasi-particle state. Sources of 105Cd were produced via the 106Cd(n,2n) reaction on enriched 106CdO using 14 MeV neutrons. A total of 274 γ-rays are attributed to the decay of 105Cd, and 248 of these have been placed in a 105Ag level scheme involving 50 excited states. Absolute values for the β+/EC transition intensities to 105Ag levels were determined. The β+/EC feeding from the 5/2+105Cd to the 7/2+ 25.5-keV isomeric state in 105Ag was determined to be (51.4 +- 4.0) percent (log ft = 5.4). The experimentally determined level structures of 131I and 105Cd are interpreted in terms of the shell model and core excitation considerations with emphasis placed on the core coupling model and the three-particle models. (U.S.)

  6. Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus

    Hayashi, Ikuko; Oyama, Takuji; Morikawa, Kosuke

    2001-01-01

    Proper placement of the bacterial cell division site requires the site-specific inactivation of other potential division sites. In Escherichia coli, selection of the correct mid-cell site is mediated by the MinC, MinD and MinE proteins. To clarify the functional role of the bacterial cell division inhibitor MinD, which is a membrane-associated ATPase that works as an activator of MinC, we determined the crystal structure of a Pyrococcus furiosus MinD homologue complexed with a substrate analo...

  7. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

    Janakiram, Naveena B; Altaf Mohammed; Li Qian; Chang-In Choi; Steele, Vernon E.; Rao, Chinthalapally V.

    2012-01-01

    Retinoid X receptor (RXR) has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics). Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. ...

  8. Comparison between DSm and MinC Combination Rules. Chapter 10

    Daniel, Milan

    Rehoboth : American Research Press, 2004 - (Smarandache, F.; Dezert, J.), s. 223-241 ISBN 1-931233-82-9 R&D Projects: GA MŠk OC 274.001 Grant ostatní: COST(XE) Action 274 TARSKI Institutional research plan: CEZ:AV0Z1030915 Keywords : belief functions * combination of belief functions * Dempster-Shafer theory * Dezert-Smarandache theory * minC combination Subject RIV: BA - General Mathematics

  9. The effect of exercise on IL-6-induced cachexia in the Apc Min /+ mouse

    Puppa, Melissa J.; White, James P.; Kandy T Velázquez; Baltgalvis, Kristen A.; Sato, Shuichi; Baynes, John W.; Carson, James A.

    2011-01-01

    Background Cachexia involves unintentional body weight loss including diminished muscle and adipose tissue mass and is associated with an underlying disease. Systemic overexpression of IL-6 accelerates cachexia in the ApcMin/+ mouse, but does not induce wasting in control C57BL/6 mice. With many chronic diseases, chronic inflammation and metabolic dysfunction can be improved with moderate exercise. A direct effect of regular moderate exercise on the prevention of IL-6-induced cachexia in the ...

  10. Comprehensive Evaluation on Ecological Security in the Upper Min River Basin

    Shang-chun, Xie; Hui, Liu; Ze-hong, Zhang

    2010-01-01

    Related literatures about ecological fragile is reviewed; the current status of ecological environment in the upper Min River basin is summarized. Equations for calculating the ecological footprint and ecological carrying capacity, as well as the standards of evaluating the status of ecological security are introduced. When ecological carrying capacity is greater than ecological footprint, ecosystem in this region is in safe state, and vice verse. According to the research data about five cou...

  11. Human Connectome Module Pattern Detection Using A New Multi-Graph MinMax Cut Model

    Wang; Wang, Yang; Nie, Feiping; Yan, Jingwen; Cai, Weidong; Saykin, Andrew J; Shen, Li; Huang, Heng

    2014-01-01

    Many recent scientific efforts have been devoted to constructing the human connectome using Diffusion Tensor Imaging (DTI) data for understanding the large-scale brain networks that underlie higher-level cognition in human. However, suitable computational network analysis tools are still lacking in human connectome research. To address this problem, we propose a novel multi-graph min-max cut model to detect the consistent network modules from the brain connectivity networks of all studied sub...

  12. A Generalization of the minC Combination to DSm Hyper-Power Sets

    Daniel, Milan

    Paris: Editions EDK, 2006 - (Bouchon-Meunier, B.; Yager, R.), s. 420-427 ISBN 2-84254-112-X. [IPMU 2006 /11./. Paris (FR), 02.07.2006-07.07.2006] R&D Projects: GA AV ČR 1ET100300419 Institutional research plan: CEZ:AV0Z10300504 Keywords : belief fuction * combination of belief functions * Dempster-Shafer theory * conflict * minC combination * DSm theory * DSm combination rule Subject RIV: BA - General Mathematics

  13. Sampled Weighted Min-Hashing for Large-Scale Topic Mining

    Fuentes-Pineda, Gibran; Meza-Ruiz, Ivan Vladimir

    2015-01-01

    We present Sampled Weighted Min-Hashing (SWMH), a randomized approach to automatically mine topics from large-scale corpora. SWMH generates multiple random partitions of the corpus vocabulary based on term co-occurrence and agglomerates highly overlapping inter-partition cells to produce the mined topics. While other approaches define a topic as a probabilistic distribution over a vocabulary, SWMH topics are ordered subsets of such vocabulary. Interestingly, the topics mined by SWMH underlie ...

  14. An information-theoretic derivation of min-cut based clustering

    Raj, Anil; Wiggins, Chris H.

    2010-01-01

    Min-cut clustering, based on minimizing one of two heuristic cost-functions proposed by Shi and Malik nearly a decade ago, has spawned tremendous research, both analytic and algorithmic, in the graph partitioning and image segmentation communities over the last decade. It is however unclear if these heuristics can be derived from a more general principle facilitating generalization to new problem settings. Motivated by an existing graph partitioning framework, we derive relationships between ...

  15. Syntheses, structures, and optical properties of Ba4MInSe6 (M=Cu, Ag)

    Two new quaternary chalcogenides, namely Ba4MInSe6 (M=Cu, Ag), were synthesized by solid state reactions. These two isostructural compounds adopt the Ba2MnS3 structure type in the orthorhombic space group Pnma. In the structure, the M and In atoms randomly occupy one crystallographic unique metal position with the molar ratio of 1:1 The (M/In)Se4 tetrahedra are connected to each other by corner-sharing to form one-dimensional chains along the b direction, which are separated by mono-capped trigonal prismatically coordinated Ba atoms. Based on the diffuse reflectance spectrum, the optical band gaps were determined to be 2.23(2) and 2.41(2) eV for Ba4CuInSe6 and Ba4AgInSe6, respectively. - Graphical abstract: In the structure of Ba4MInSe6 (M=Cu, Ag), the (M/In)Se4 tetrahedra are connected by corner-sharing to form chains along the b direction, which are separated by Ba atoms. Highlights: ► Two new quaternary chalcogenides, Ba4MInSe6 (M=Cu, Ag), were synthesized. ► Ba4MInSe6 (M=Cu, Ag) are isostructural and crystallize in the Ba2MnS3 structure type ► The (M/In)Se4 tetrahedra are connected by corner-sharing to form chains along the b direction. ► The chains are separated by mono-capped trigonal prismatically coordinated Ba atoms. ► The optical band gaps are 2.23(2) and 2.41(2) eV for Ba4CuInSe6 and Ba4AgInSe6, respectively.

  16. Discovering Non-Redundant Association Rules using MinMax Approximation Rules

    R. Vijaya Prakash

    2012-12-01

    Full Text Available Frequent pattern mining is an important area of data mining used to generate the Association Rules. The extracted Frequent Patterns quality is a big concern, as it generates huge sets of rules and many of them are redundant. Mining Non-Redundant Frequent patterns is a big concern in the area of Association rule mining. In this paper we proposed a method to eliminate the redundant Frequent patterns using MinMax rule approach, to generate the quality Association Rules.

  17. The new 157Tm isotope, Tsub(1/2)=(3.6+-0.3) min

    The new isotope 157Tm was discovered, and its half-life Tsub(1/2) (3.6+-0.3)min was measured. On the basis of the balance of energies and intensities of γ-transitions occurring in the 157Tm decay a number of excited states of the 157Er nucleus with energies of 110.2; 241.3; 357.3 and 457.1 keV were found. (author)

  18. KoBaMIN: a knowledge-based minimization web server for protein structure refinement.

    Rodrigues, João P G L M; Levitt, Michael; Chopra, Gaurav

    2012-07-01

    The KoBaMIN web server provides an online interface to a simple, consistent and computationally efficient protein structure refinement protocol based on minimization of a knowledge-based potential of mean force. The server can be used to refine either a single protein structure or an ensemble of proteins starting from their unrefined coordinates in PDB format. The refinement method is particularly fast and accurate due to the underlying knowledge-based potential derived from structures deposited in the PDB; as such, the energy function implicitly includes the effects of solvent and the crystal environment. Our server allows for an optional but recommended step that optimizes stereochemistry using the MESHI software. The KoBaMIN server also allows comparison of the refined structures with a provided reference structure to assess the changes brought about by the refinement protocol. The performance of KoBaMIN has been benchmarked widely on a large set of decoys, all models generated at the seventh worldwide experiments on critical assessment of techniques for protein structure prediction (CASP7) and it was also shown to produce top-ranking predictions in the refinement category at both CASP8 and CASP9, yielding consistently good results across a broad range of model quality values. The web server is fully functional and freely available at http://csb.stanford.edu/kobamin. PMID:22564897

  19. The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model.

    Svendsen, Camilla; Høie, Anja Hortemo; Alexander, Jan; Murkovic, Michael; Husøy, Trine

    2016-08-01

    Glyoxal is formed endogenously and at a higher rate in the case of hyperglycemia. Glyoxal is also a food processing contaminant and has been shown to be mutagenic and genotoxic in vitro. The tumourigenic potential of glyoxal was investigated using the multiple intestinal neoplasia (Min) mouse model, which spontaneously develops intestinal tumours and is susceptible to intestinal carcinogens. C57BL/6J females were mated with Min males. Four days after mating and throughout gestation and lactation, the pregnant dams were exposed to glyoxal through drinking water (0.0125%, 0.025%, 0.05%, 0.1%) or regular tap water. Female and male offspring were housed separately from PND21 and continued with the same treatment. One group were only exposed to 0.1% glyoxal from postnatal day (PND) 21. There was no difference in the number of intestinal tumours between control and treatment groups. However, exposure to 0.1% glyoxal starting in utero and at PND21 caused a significant increase in tumour size in the small intestine for male and female mice in comparison with respective control groups. This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice. PMID:27288931

  20. Viability of adhered bacterial cells: tracking MinD protein oscillations

    Barrett, Matt; Colville, Keegan; Schultz-Nielsen, Chris; Jericho, Manfred; Dutcher, John

    2010-03-01

    To study bacterial cells using atomic force microscopy, it is necessary to immobilize the cells on a substrate. Because bacterial cells and common substrates such as glass and mica have a net negative charge, positively charged polymers such as poly-L-lysine (PLL) and polyethyleneimine (PEI) are commonly used as adhesion layers. However, the use of adhesion polymers could stress the cell and even render it inviable. Viable E. coli cells use oscillations of Min proteins along the axis of the rod-shaped cells to ensure accurate cell division. By tagging MinD proteins with GFP, oscillations can be observed using fluorescence microscopy. For a healthy cell in an ideal environment, the oscillation period is measured to be ˜40 s. Prior experiments have shown that PLL increases the oscillation period significantly (up to 80%). In the present study, we have used epifluorescence and total internal reflection fluorescence (TIRF) to track MinD protein oscillations in E. coli bacteria adhered to a variety of positively charged polymers on mica as a function of polymer surface coverage.

  1. Character recognition using min-max classifiers designed via an LMS algorithm

    Yang, Ping-Fai; Maragos, Petros

    1992-11-01

    In this paper we propose a Least Mean Square (LMS) algorithm for the practical training of the class of min-max classifiers. These are lattice-theoretic generalization of Boolean functions and are also related to feed-forward neural networks and morphological signal operators. We applied the LMS algorithm to the problem of handwritten character recognition. The database consists of segmented and cleaned digits. Features that were extracted from the digits include Fourier descriptors and morphological shape-size histograms. Experimental results using the LMS algorithm for handwritten character recognition are promising. In our initial experimentation, we applied the min-max classifier to binary classification of '0' and '1' digits. By preprocessing the feature vectors, we were able to achieve an error rate of 1.75% for a training set of size 1200 (600 of each digit); and an error rate of 4.5% on a test set of size 400 (200 of each). These figures are comparable to those obtained by 2-layer neural nets trained using back propagation. The major advantage of min-max classifiers compared to neural networks is their simplicity and the faster convergence of their training algorithm.

  2. The max–min ant system and tabu search for pressurized water reactor loading pattern design

    Highlights: • An automatic loading pattern design tool for a pressurized water reactor is developed. • The design method consists of max–min ant system and tabu search. • The heuristic rules are developed to generate the candidates for tabu search. • The initial solution of tabu search is provided by max–min ant system. • The new algorithm shows very satisfactory results compared to the old one. - Abstract: An automatic loading pattern (LP) design tool for a pressurized water reactor is developed. The design procedure consists of two steps: first, a LP is generated using max–min ant system (MMAS) and then tabu search (TS) is adopted to search the satisfactory LP. The MMAS is previously developed and the TS process is newly-developed. The heuristic rules are implemented to generate the candidate LP in TS process. The heuristic rules are comprised of two kinds of action, i.e., a single swap in the location of two fuel assemblies and rotation of fuel assembly. Since developed TS process is a local search algorithm, it is efficient for the minor change of LP. It means that a proper initial LP should be provided by the first step, i.e., by MMAS. The design requirements such as hot channel factor, the hot zero power moderator temperature coefficient, and cycle length are formulated in the objective function. The results show that the developed tool can obtain the satisfactory LP and dramatically reduce the computation time compared with previous tool using ant system alone

  3. Effect of 30-min +3 Gz centrifugation on vestibular and autonomic cardiovascular function

    Schlegel, Todd T.; Wood, Scott J.; Brown, Troy E.; Harm, Deborah L.; Rupert, A. H.

    2003-01-01

    INTRODUCTION: Repeated exposure to increased +Gz enhances human baroreflex responsiveness and improves tolerance to cardiovascular stress. However, it is not known whether such enhancements might also result from a single, more prolonged exposure to increased +Gz. Our study was designed to investigate whether baroreflex function and orthostatic tolerance are acutely improved by a single prolonged exposure to +3 Gz, and moreover, whether changes in autonomic cardiovascular function resulting from exposure to increased +Gz are correlated with changes in otolith function. METHODS: We exposed 15 healthy human subjects to +3 Gz centrifugation for up to 30 min or until symptoms of incipient G-induced loss of consciousness (G-LOC) ensued. Tests of autonomic cardiovascular function both before and after centrifugation included: 1) power spectral determinations of beat-to-beat R-R intervals and arterial pressures; 2) carotid-cardiac baroreflex tests; 3) Valsalva tests; and 4) 30-min head-up tilt tests. Otolith function was assessed during centrifugation by the linear vestibulo-ocular reflex and both before and after centrifugation by measurements of ocular counter-rolling and dynamic posturography. RESULTS: Of the 15 subjects who underwent prolonged +3 Gz, 4 were intolerant to 30 min of head-up tilt before centrifugation but became tolerant to such tilt after centrifugation. The Valsalva-related baroreflex as well as a measure of the carotid-cardiac baroreflex were also enhanced after centrifugation. No significant vestibular-autonomic relationships were detected beyond a vestibular-cerebrovascular interaction reported earlier in a subset of seven participants. CONCLUSIONS: A single prolonged exposure to +3 Gz centrifugation acutely improves baroreflex function and orthostatic tolerance.

  4. Permutation Min-Entropy and Statistical Complexity Analysis of Electricity Spot Price

    Fan, Qingju; Li, Dan

    2015-10-01

    In this study, we investigate the subtle temporal dynamics of California 1999-2000 spot price series based on permutation min-entropy (PME) and complexity-entropy causality plane. The dynamical transitions of price series are captured and the temporal correlations of price series are also discriminated by the recently introduced PME. Moreover, utilizing the CECP, we provide a refined classification of the monthly price dynamics and obtain an insight into the stochastic nature of price series. The results uncover that the spot price signal presents diverse temporal correlations and exhibits a higher stochastic behavior during the periods of crisis.

  5. Min-Max Theorems Related to Geometric Representations of Graphs and their SDPs

    Silva, Marcel K Carli

    2010-01-01

    We prove a simple nonlinear identity relating the Lov{\\'a}sz theta number of a graph to its smallest radius hypersphere embedding where each edge has unit length. We use this identity and its generalizations to establish min-max theorems and to translate results related to one of the graph invariants above to the other. Classical concepts in tensegrity theory allow good interpretations of the dual SDP for the problem of finding an optimal hypersphere embedding as above. We generate a spectrum of structured SDPs on which extensions of such interpretations are possible.

  6. PMMA mPOF Bragg gratings written in less than 10 min

    Bundalo, Ivan-Lazar; Nielsen, Kristian; Markos, Christos;

    2014-01-01

    Fiber Bragg grating (FBG) writing in PMMA microstructured Polymer Optical Fibers (mPOFs) using the UV Phase Mask technique is a time consuming process requiring about 40 minutes to inscribe a grating in an undoped fiber. Here we demonstrate the FBG inscription with the writing times shorter than 10...... min. By careful alligning and increasing the beam intensity in the core of the fiber, writing times as short as 6 minutes and 50 second were achieved. The FBGs were written in a 125 μm PMMA mPOF having 3-rings of holes, the reflection peaks were centred at 632.6 nm and have a reflectivity as high as...

  7. Constrained Multi-user Multi-server Max-Min Fair Queuing

    Khamse-Ashari, Jalal; Lambadaris, Ioannis; Zhao, Yiqiang

    2016-01-01

    In this paper, a multi-user multi-server queuing system is studied in which each user is constrained to get service from a subset of servers. In the studied system, rate allocation in the sense of max-min fairness results in multi-level fair rates. To achieve such fair rates, we propose $CM^4FQ$ algorithm. In this algorithm users are chosen for service on a packet by packet basis. The priority of each user $i$ to be chosen at time $t$ is determined based on a parameter known as service tag (r...

  8. Intestinal Peyer’s patches prevent tumorigenesis in Apc Min/+ mice

    Fujimoto, Kyoko; Fujii, Gen; Sakurai, Hitomi; Yoshitome, Hiroko; Mutoh, Michihiro; Wada, Morimasa

    2014-01-01

    Peyer’s patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer’s patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer’s patches and of the development of intestinal polyps in Apc Min/+ mice, which are a useful model to clarify the role of Peyer’s patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer’s patc...

  9. Illumination Tolerance for Visual Navigation with the Holistic Min-Warping Method

    Ralf Möller

    2014-02-01

    Full Text Available Holistic visual navigation methods are an emerging alternative to the ubiquitous feature-based methods. Holistic methods match entire images pixel-wise instead of extracting and comparing local feature descriptors. In this paper we investigate which pixel-wise distance measures are most suitable for the holistic min-warping method with respect to illumination invariance. Two novel approaches are presented: tunable distance measures—weighted combinations of illumination-invariant and illumination-sensitive terms—and two novel forms of “sequential” correlation which are only invariant against intensity shifts but not against multiplicative changes. Navigation experiments on indoor image databases collected at the same locations but under different conditions of illumination demonstrate that tunable distance measures perform optimally by mixing their two portions instead of using the illumination-invariant term alone. Sequential correlation performs best among all tested methods, and as well but much faster in an approximated form. Mixing with an additional illumination-sensitive term is not necessary for sequential correlation. We show that min-warping with approximated sequential correlation can successfully be applied to visual navigation of cleaning robots.

  10. Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model.

    Notarnicola, Maria; Barone, Michele; Francavilla, Antonio; Tutino, Valeria; Bianco, Giusy; Tafaro, Angela; Minoia, Mario; Polimeno, Lorenzo; Napoli, Anna; Scavo, Maria Principia; Caruso, Maria Gabriella

    2016-08-01

    The statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) and orlistat, an inhibitor of fatty acid synthase (FAS), inhibit tumor cell growth by restricting cholesterol and fatty acid synthesis, respectively. We previously demonstrated that an omega (ω)-3 polyunsaturated fatty acid (PUFA)- or olive oil-enriched diet reduced the polyp number and volume in ApcMin/+ mice. This phenomenon was associated with a significant inhibition of FAS and HMGCoAR, as well as an increase in the estrogen receptor (ER)β/α ratio. Herein, we evaluated the effect of lovastatin and orlistat on polyp development and ER expression in ApcMin/+ mice, in order to confirm previous data obtained with ω‑3-PUFAs and olive oil. As expected, the use of lovastatin and orlistat significantly reduced HMGCoAR and FAS enzymatic activities and gene expression in colonic tissues, but did not affect the number of intestinal polyps, while there was a statistically significant reduction in polyp volume only in the mouse group treated with lovastatin. In the mice receiving orlistat, we observed a significant increase in cell proliferation in the polyp tissue, as well as enhanced expression of ERα. Moreover, the overexpression of ERα was associated with a statistically significant increase in PES1, Shh and Gli1 protein levels, considered ERα-related molecular targets. PMID:27277576

  11. The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice

    Ets transcription factors have been widely implicated in the control of tumorigenesis, with most studies suggesting tumor-promoting roles. However, few studies have examined Ets tumorigenesis-modifying functions in vivo using model genetic systems. Using mice expressing a previously characterized Ets dominant repressor transgene in the intestinal epithelium (Villin-En/Erm), we examined the consequences of blocking endogenous Ets-mediated transcriptional activation on tumorigenesis in the ApcMin model of intestinal carcinoma. En/Erm expression in the intestine, at levels not associated with overt crypt-villus dysmorphogenesis, results in a marked increase in tumor number in ApcMin animals. Moreover, when examined histologically, tumors from En/Erm-expressing animals show a trend toward greater stromal invasiveness. Detailed analysis of crypt-villus homeostasis in these En/Erm transgenic animals suggests increased epithelial turnover as one possible mechanism for the enhanced tumorigenesis. Our findings provide in vivo evidence for a tumor-restricting function of endogenous Ets factors in the intestinal epithelium

  12. Liang Shu-min and Buddhism%梁漱溟与佛学

    张文儒

    2001-01-01

    Liang Shu-min was a celebrated figure in modern Chine se history,famous for his life principle “upright and independent, honest and frank". Speaking from his academic thought, he considered the essence of his thought was Confucianism and Buddhism. From the reasons why he believed in Buddhism, his contributions to Buddhism in India and his comparisons between the Buddhism and Confucianism, one can see that Liang Shu-min's Buddhism thought was not only an ideology he accepted but also the essential motive that he practiced all his life.%梁漱溟是中国现代史上一位著名人物。他以“特立独行、一代直声”饮誉后世。在学术思想上,他自认思想的根本是儒家和佛家。从他为什么会信佛和他对印度佛学研究的贡献及对于儒佛异同的比较等几个方面,可以看出梁漱溟佛学思想不只是他终身服膺的一种思想学说,也是他一生践履的根本动力。

  13. Regional cerebral oxygen saturation in newborn infants in the first 15 min of life after vaginal delivery

    The objective of this study was to evaluate regional oxygen saturation of the brain during immediate transition after birth, and to correlate it with pre-ductal arterial oxygen saturation in newborn infants. The prospective observational study including newborn infants in the first 15 min after spontaneous vaginal delivery and uncomplicated transitional period was undertaken. Regional cerebral oxygen saturation (rSO2brain) was measured using near-infrared spectroscopy. Arterial oxygen saturation (SpO2) and heart rate (HR) were measured on the right wrist by pulse oximetry. rSO2brain, SpO2 and HR measurements were started immediately after birth and were performed in the first 15 min of life. Cerebral fractional tissue oxygen extraction (FTOE) was calculated for each minute. Of 145 newborn infants, 16 were included and the gender allocation was 31 females (49.2%) and 32 males (50.8%). rSO2brain increased rapidly from 39% (2 min) to 69% (5 min), SpO2 increased from 72% (2 min) to 96% (14 min) and FTOE showed a significant decrease from minute 2 (0.47) until minute 4 (0.30) and an increase between 8 to 13 min. rSO2brain increased rapidly after vaginal delivery. Although SpO2 increased within the first 14 min after delivery, rSO2brain showed no further significant changes after 5 min. FTOE decreased in the first 4 min and reached standard values subsequently. (paper)

  14. Data from the Mars Science Laboratory CheMin XRD/XRF Instrument

    Vaniman, David; Blake, David; Bristow, Tom; DesMarais, David; Achilles, Cherie; Anderson, Robert; Crips, Joy; Morookian, John Michael; Spanovich, Nicole; Vasavada, Ashwin; Yen, Albert; Bish, David; Chipera, Steve; Downs, Robert; Morrison, Shaunna; Farmer, Jack; Grotzinger, John; Stolper, Edward; Ming, Douglas; Morris, Richard; Rampe, Elizabeth; Treiman, Allan; Sarrazin, Philippe

    2013-01-01

    The CheMin instrument on the Mars Science Laboratory (MSL) rover Curiosity uses a Co tube source and a CCD detector to acquire mineralogy from diffracted primary X-rays and chemical information from fluoresced X-rays. CheMin has been operating at the MSL Gale Crater field site since August 5, 2012 and has provided the first X-ray diffraction (XRD) analyses in situ on a body beyond Earth. Data from the first sample collected, the Rocknest eolian soil, identify a basaltic mineral suite, predominantly plagioclase (approx.An50), forsteritic olivine (approx.Fo58), augite and pigeonite, consistent with expectation that detrital grains on Mars would reflect widespread basaltic sources. Minor phases (each <2 wt% of the crystalline component) include sanidine, magnetite, quartz, anhydrite, hematite and ilmenite. Significantly, about a third of the sample is amorphous or poorly ordered in XRD. This amorphous component is attested to by a broad rise in background centered at approx.27deg 2(theta) (Co K(alpha)) and may include volcanic glass, impact glass, and poorly crystalline phases including iron oxyhydroxides; a rise at lower 2(theta) may indicate allophane or hisingerite. Constraints from phase chemistry of the crystalline components, compared with a Rocknest bulk composition from the APXS instrument on Curiosity, indicate that in sum the amorphous or poorly crystalline components are relatively Si, Al, Mg-poor and enriched in Ti, Cr, Fe, K, P, S, and Cl. All of the identified crystalline phases are volatile-free; H2O, SO2 and CO2 volatile releases from a split of this sample analyzed by the SAM instrument on Curiosity are associated with the amorphous or poorly ordered materials. The Rocknest eolian soil may be a mixture of local detritus, mostly crystalline, with a regional or global set of dominantly amorphous or poorly ordered components. The Rocknest sample was targeted by MSL for "first time analysis" to demonstrate that a loose deposit could be scooped, sieved to

  15. Quantitative Proteomics Analysis Reveals the Min System of Escherichia coli Modulates Reversible Protein Association with the Inner Membrane.

    Lee, Hsiao-Lin; Chiang, I-Chen; Liang, Suh-Yuen; Lee, Der-Yen; Chang, Geen-Dong; Wang, Kwan-Yu; Lin, Shu-Yu; Shih, Yu-Ling

    2016-05-01

    The Min system of Escherichia coli mediates placement of the division septum at the midcell. It oscillates from pole to pole to establish a concentration gradient of the division inhibition that is high at the poles but low at the midcell; the cell middle thereby becomes the most favorable site for division. Although Min oscillation is well studied from molecular and biophysical perspectives, it is still an enigma as to whether such a continuous, energy-consuming, and organized movement of the Min proteins would affect cellular processes other than the division site selection. To tackle this question, we compared the inner membrane proteome of the wild-type and Δmin strains using a quantitative approach. Forty proteins that showed differential abundance on the inner membrane of the mutant cells were identified and defined as proteins of interest (POIs). More than half of the POIs were peripheral membrane proteins, suggesting that the Min system affects mainly reversible protein association with the inner membrane. In addition, 6 out of 10 selected POIs directly interacted with at least one of the Min proteins, confirming the correlation between POIs and the Min system.Further analysis revealed a functional relationship between metabolism and the Min system. Metabolic enzymes accounted for 45% of the POIs, and there was a change of metabolites in the related reactions. We hypothesize that the Min system could alter the membrane location of proteins to modulate their enzymatic activity. Thus, the metabolic modulation in the Δmin mutant is likely an adaptive phenotype in cells of abnormal size and chromosome number due to an imbalanced abundance of proteins on the inner membrane. Taken together, the current work reports novel interactions of the Min system and reveals a global physiological impact of the Min system in addition to the division site placement. PMID:26889046

  16. Identification of the Modifier of Min 2 (Mom2) Locus, a New Mutation That Influences Apc-Induced Intestinal Neoplasia

    Silverman, Karen A.; Koratkar, Revati; Linda D. Siracusa; Buchberg, Arthur M.

    2002-01-01

    Min (Multiple intestinal neoplasia) mice carry a dominant mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their intestinal tract (Moser et al. 1990; Su et al. 1992). Polyp multiplicity in Min mice is greatly influenced by genetic background. A modifier locus, Mom1 (Modifier of Min 1), was identified and localized to distal mouse chromosome 4 (Moser et al. 1992; Dietrich et al. 1993), and accounts for some of the genetic variance in polyp multipli...

  17. Avancées dans le domaine de la thermodynamique des minéraux argileux

    Blanc, Philippe; Vieillard, Philippe; Gailhanou, Hélène; Gaboreau, Stéphane; Tournassat, Christophe; Madé, Benoit; Giffaut, Eric; Bergaya, Faiza

    2013-01-01

    La connaissance des propriétés thermodynamiques des minéraux argileux représente un enjeu important pour la mise en oeuvre et la sécurité à long terme des installations de stockage sous-terrain, pour le stockage de déchets nucléaire, de CO2 ou de toute autre substance dangereuse. Ces propriétés, issues pour la plupart d'expériences de mise à l'équilibre plus ou moins bien contrôlées ou de méthodes d'estimation souffrant d'un déficit de données pour leur calibration, étaient considérées comme ...

  18. Glucose enhances collectrin protein expression in insulin-producing MIN6 {beta} cells

    Saisho, Kenji; Fukuhara, Atsunori [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Yasuda, Tomoko [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan); Sato, Yoshifumi; Fukui, Kenji; Iwahashi, Hiromi; Imagawa, Akihisa [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Hatta, Mitsutoki [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan); Shimomura, Iichiro [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Yamagata, Kazuya, E-mail: k-yamaga@kumamoto-u.ac.jp [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan)

    2009-11-06

    Collectrin is a novel target gene of hepatocyte nuclear factor-1{alpha} in pancreatic {beta}-cells and controls insulin exocytosis. Although glucose is known to stimulate the expression of genes of the insulin secretory pathway, there is no information on how glucose regulates collectrin expression. We investigated the effects of glucose on the expression of collectrin in MIN6 {beta}-cell line. Glucose, in a dose-dependent manner, increased collectrin protein levels without changing collectrin mRNA levels and protein stability, indicating that glucose stimulation of collectrin protein expression is primarily mediated at a translational level. Although mannose and pyruvate also increased collectrin protein expression level, neither 2-deoxyglucose, mitochondrial fuels leucine and glutamate, sulphonylurea nor Ca{sup 2+} channel blockers, mimicked the effects of glucose. These data indicate the involvement of mitochondrial TCA cycle intermediates, distal to pyruvate, in the regulation of collectrin protein expression in {beta}-cells.

  19. Quicksort, largest bucket, and min-wise hashing with limited independence

    Knudsen, Mathias Bæk Tejs; Stöckel, Morten

    2015-01-01

    k-independent if every variable is uniform and every size k subset is independent. In this paper we consider three classic algorithms under limited independence. Besides the theoretical interest in removing the unrealistic assumption of full independence, the work is motivated by lower independence......Randomized algorithms and data structures are often analyzed under the assumption of access to a perfect source of randomness. The most fundamental metric used to measure how “random” a hash function or a random number generator is, is its independence: a sequence of random variables is said to be...... being more practical. We provide new bounds for randomized quicksort, min-wise hashing and largest bucket size under limited independence. Our results can be summarized as follows. Randomized Quicksort. When pivot elements are computed using a 5-independent hash function, Karloff and Raghavan, J.ACM’93...

  20. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers

    Christensen, Peter Møller; Petersen, Mads H; Friis, Signe N;

    2014-01-01

    This study examined the ergogenic effects in a 6 min maximal performance test (PT) on 12 elite rowers: 6 open-weight (mean ± SD; 25 ± 1 years, and 92 ± 3 kg) and 6 light-weight (25 ± 3 years, and 73 ± 6 kg), following supplementation with caffeine (CAF), sodium bicarbonate (SB), and the combination...... distance; P < 0.05) than in open-weight rowers (0.3% ± 0.8%; P > 0.05). No difference between interventions was observed for readiness and stomach comfort before PT and perceived exertion during PT. This study demonstrates that caffeine ingestion does improve performance in elite rowing. In contrast sodium...... bicarbonate does not appear to be ergogenic, but it does not abolish the ergogenic effect of caffeine....

  1. PWRs in UK and China use 3000r/min turbines

    The new steam turbine design by GEC Turbine Generators Ltd. are 3 to 5 percentage points more efficient than previous turbine designs. They also require fewer manufacturing manhours to make. GEC has won the contracts for the steam turbine at the Daya Bay power station in China and Sizewell-B in the UK. Both are pressurized water reactors. The main parameters for these 300r/min steam turbines are listed. The existing and new GEC turbines for water cooled reactors are listed and the operation of the new turbines is explained. The high pressure stop and governing valves and the arrangement of spring-supported horizontal high pressure valve chests are illustrated. (UK)

  2. A Randomized Load Balancing Algorithm In Grid using Max Min PSO Algorithm

    C.Kalpana

    2012-04-01

    Full Text Available Grid computing is a new paradigm for next generation computing, it enables the sharing and selection of geographically distributed heterogeneous resources for solving large scale problems in science and engineering. Grid computing does require special software that is unique to the computing project for which the grid is being used. In this paper the proposed algorithm namely dynamic load balancing algorithm is created for job scheduling in Grid computing. Particle Swarm Intelligence (PSO is the latest evolutionary optimization techniques in Swarm Intelligence. It has the better performance of global searching and has been successfully applied to many areas. The performance measure used for scheduling is done by Quality of service (QoS such as makespan, cost and deadline. Max PSO and Min PSO algorithm has been partially integrated with PSO and finally load on the resources has been balanced.

  3. Min Bei Irradiation Center. Food and Agriculture organization project experience, Jianou, Fujian Province, China

    The Food and Agriculture Organization (FAO), a United Nations Organization, in an effort to increase food supplies by post harvest irradiation treatment, participated in the development of the Min Bei Irradiation Center (MBIC) located in Fujian Province, China. FAO in conjunction with Shanghai Nuclear Energy Research and Design Institute (SNERDI), MBIC staff, and the Ministry of Agriculture completed Project TCP CPR 6763/8961 culminating in the recent commissioning of one of China's newest irradiation facilities. From the feasibility phase initiated in 1986, through the construction period and the eventual commissioning in 1991, FAO participated in the technical overview of the irradiation center. MBIC was developed both as a research and development center as well as a production irradiation facility for the primary purpose of reduction of post harvest food loss in Fujian Province. This retrospective review of the project provides a hindsight view for the development of MBIC. (author)

  4. Mash: fast genome and metagenome distance estimation using MinHash.

    Ondov, Brian D; Treangen, Todd J; Melsted, Páll; Mallonee, Adam B; Bergman, Nicholas H; Koren, Sergey; Phillippy, Adam M

    2016-01-01

    Mash extends the MinHash dimensionality-reduction technique to include a pairwise mutation distance and P value significance test, enabling the efficient clustering and search of massive sequence collections. Mash reduces large sequences and sequence sets to small, representative sketches, from which global mutation distances can be rapidly estimated. We demonstrate several use cases, including the clustering of all 54,118 NCBI RefSeq genomes in 33 CPU h; real-time database search using assembled or unassembled Illumina, Pacific Biosciences, and Oxford Nanopore data; and the scalable clustering of hundreds of metagenomic samples by composition. Mash is freely released under a BSD license ( https://github.com/marbl/mash ). PMID:27323842

  5. Minerals detection for hyperspectral images using adapted linear unmixing: LinMin

    Frederic, Schmidt; Stephane, Le Mouelic

    2014-01-01

    Minerals detection over large volume of spectra is the challenge addressed by current hyperspectral imaging spectrometer in Planetary Science. Instruments such OMEGA (Mars Express), CRISM (Mars Reconnaissance Orbiter), M^{3} (Chandrayaan-1), VIRTIS (Rosetta) and many more, have been producing very large datasets since one decade. We propose here a fast supervised detection algorithm called LinMin, in the framework of linear unmixing, with innovative arrangement in order to treat non-linear cases due to radiative transfer in both atmosphere and surface. We use reference laboratory and synthetic spectral library. Additional spectra are used in order to mimic the effect of Martian aerosols, grain size, and observation geometry discrepancies between reference and observed spectra. The proposed algorithm estimates the uncertainty on mixing coefficient from the uncertainty of observed spectra. Both numerical and observational tests validate the approach. Fast parallel implementation of the best algorithm (IPLS) on ...

  6. Simple Max-Min Ant Systems and the Optimization of Linear Pseudo-Boolean Functions

    Kötzing, Timo; Sudholt, Dirk; Wagner, Markus

    2010-01-01

    With this paper, we contribute to the understanding of ant colony optimization (ACO) algorithms by formally analyzing their runtime behavior. We study simple MAX-MIN ant systems on the class of linear pseudo-Boolean functions defined on binary strings of length 'n'. Our investigations point out how the progress according to function values is stored in pheromone. We provide a general upper bound of O((n^3 \\log n)/ \\rho) for two ACO variants on all linear functions, where (\\rho) determines the pheromone update strength. Furthermore, we show improved bounds for two well-known linear pseudo-Boolean functions called OneMax and BinVal and give additional insights using an experimental study.

  7. 基于QoS Guided Min-min改进后的网格调度算法

    徐益强; 王志坚; 许峰

    2007-01-01

    在对网格调度现有算法的研究基础之上,对QoS Guided Min-min算法进行了分析,介绍了在任务对资源有特殊要求时算法的不足,并对其进行了改进.最后,使用GridSim模拟任务调度,对Min-min算法、QoS Guided Min-min算法和改进后的QoS Guided Min-min算法进行对比分析,验证了改进后算法的高效性.

  8. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

    Naveena B. Janakiram

    2012-02-01

    Full Text Available Retinoid X receptor (RXR has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics. Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. Before the efficacy studies, we determined that the maximal tolerated dose in C57BL/6J mice was less than 400 ppm. For the efficacy study, 6-week-old male and female C57BL/6J-ApcMin/+ mice (nine mice per group were fed diets containing 0, 30, and 60 ppm of bexarotene or 200 ppm of bexarotene for 80 days before intestinal tumors were evaluated. Dietary administration of 30 and 60 ppm of bexarotene suppressed the intestinal polyp formation by 38% (P < .015 and 60% (P < .0001 in males, respectively, and by 8.5% and 37% (P < .007 in females, respectively. Also, significant inhibition (50%–100% of colonic tumor formation was observed in both male and female mice with bexarotene treatment. Administration of 200 ppm of bexarotene showed significant suppression of tumor formation (66%, P < .0001; however, it had significant toxicity. Intestinal tumors of bexarotene-fed mice showed significantly reduced expression of proliferating cell nuclear antigen (60%, P < .0001, cyclin D1, and cyclooxygenase 2 and increased RXR-α messenger RNA and uptake of oleate (34%, P < .01. Also, bexarotene-fed mice showed dose-dependent suppression of serum triglycerides (25%–72%, P < .0001 and inflammatory cytokines.

  9. Evaluation of 20-min and Annual Radiation Budget Components and Cloudiness in a Mountainous Valley

    Malek, E.

    2007-05-01

    Logan, Utah (USA) is among cities located in the mountainous valley in the western portion of Rocky Mountains in North America. It is the county seat of Cache Valley, a metropolitan area with a population of about 100,000. The valley had the polluted air in the USA during January 2004. To evaluate the daily and annual radiation budget and cloudiness in this mountainous valley, we set up a radiation station in the middle of the valley to measure the 20- min radiation budget components namely: incoming (Rso) and outgoing (Rso) solar or shortwave radiation, using to CM21 Kipp and Zonen (one inverted) and incoming (Rli) (or atmospheric) and outgoing (Rlo) or terrestrial) longwave radiation using two CG1 Kipp and Zonen Pyrgeometers (one inverted) during the year of 2003. All pyranometers and Pyrgeometers were ventilated with four CV2 Kipp and Zonen ventilation systems throughout the year to prevent deposition of dew, frost and snow, which otherwise would disturb the measurements. We also measured the 2-m air temperature and relative humidity along with surface temperature. All measurements were taken every 2 s, averaged to 20 min, continuously throughout the year 2000. A Met One heated rain gauge measured precipitation. Comparison of the annual radiation budget components indicates that about 25% of the annual Rsi (5848.6 MJ/ (squared m-y)) was reflected back to sky as Rso. Rli and Rlo amounted to 9968.7 and 13303.5 MJ/ (squared m-y)), respectively. This yielded about 1364.9 MJ/ (squared m- y)) available energy (Rn). Having the 2-m air temperature and moisture data and comparison between the theoretical and the measured longwave radiation, we evaluated the 20-m cloudy conditions throughout the year of 2003. The average cloud base height was 587 m (ranged from zero for foggy conditions to about 3000 m). Annual cloudiness contributed about 139.1 MJ/ (squared m-y)) more energy in this valley.

  10. METAPHORIZATION AND METONYMIZATIO: DIACHRONIC DEVELOPMENT OF VERBS OF VOLITION IN SOUTHERN MIN

    Miao-Hsia Chang

    2009-06-01

    Full Text Available This paper investigates the diachrony of the verbs of volition ai and beh in Southern Min (SM. The data include historical SM texts (16th-19th century, folk songs in the late 19th to early 20th century, and contemporary natural Taiwanese Southern Min conversations. The results mainly mark two stages of the development of ai and beh: historical (before 1900 and contemporary SM. Since the 16th century (Ming Dynasty, ai has been used as a verb of volition indicating love, intention or hope. As for historical ai, it marked future, specialized however for predicting an adverse future. In contemporary SM, a sense of necessity emerged with the use of ai denoting general agreement among people. Seven senses are attributed to historical beh: want/intention/hope, future, excessiveness, necessity, proximity and conditionality. In contemporary SM, the indication of the want of an entity has become a less preferred use, and necessity is only preserved when indicating puzzlement and helplessness. The diachronic developments of ai and beh demonstrate an interplay of metaphorization and metonymization (Traugott and Dasher 2002:27. Metaphorization contributes first to the semantic shift of ai and beh from “to want; to love” to “to intend to” and a concurrent categorical change from lexical verb into auxiliary, and second, to the evolution of future. Metonymization activates an even wider range of uses and meaning change, including the pragmatic strengthening of interpretations such as excessiveness (beh, necessity (ai, beh, proximity (beh and conditional (beh, and prediction of an undesirable future (ai.

  11. MicroPET/CT Colonoscopy in long-lived Min mouse using NM404

    Christensen, Matthew B.; Halberg, Richard B.; Schutten, Melissa M.; Weichert, Jamey P.

    2009-02-01

    Colon cancer is a leading cause of death in the US, even though many cases are preventable if tumors are detected early. One technique to promote screening is Computed Tomography Colonography (CTC). NM404 is a second generation phospholipid ether analogue which has demonstrated selective uptake and prolonged retention in 43/43 types of malignant tumors but not inflammatory sites or premalignant lesions. The purpose of this experiment was to evaluate (SWR x B6 )F1.Min mice as a preclinical model to test MicroPET/CT dual modality virtual colonoscopy. Each animal was given an IV injection of 124I-NM404 (100 uCi) 24, 48 and 96 hours prior to scanning on a dedicated microPET/CT system. Forty million counts were histogrammed in 3D and reconstructed using an OSEM 2D algorithm. Immediately after PET acquisition, a 93 m volumetric CT was acquired at 80 kVp, 800 uA and 350 ms exposures. Following CT, the mouse was sacrificed. The entire intestinal tract was excised, washed, insufflated, and scanned ex vivo A total of eight tissue samples from the small intestine were harvested: 5 were benign adenomas, 2 were malignant adenocarcinomas, and 1 was a Peyer's patch (lymph tissue) . The sites of these samples were positioned on CT and PET images based on morphological cues and the distance from the anus. Only 1/8 samples showed tracer uptake. several hot spots in the microPET image were not chosen for histology. (SWR x B6)F1.Min mice develop benign and malignant tumors, making this animal model a strong candidate for future dual modality microPET/CT virtual colonography studies.

  12. The intronic minisatellite OsMin1 within a serine protease gene in the Chinese caterpillar fungus Ophiocordyceps sinensis.

    Zhang, Yong-Jie; Hou, Jun-Xiu; Zhang, Shu; Hausner, Georg; Liu, Xing-Zhong; Li, Wen-Jia

    2016-04-01

    Repetitive DNA sequences make up a significant portion of all genomes and may occur in intergenic, regulatory, coding, or even intronic regions. Partial sequences of a serine protease gene csp1 was previously used as a population genetic marker of the Chinese caterpillar fungus Ophiocordyceps sinensis, but its first intron region was excluded due to ambiguous alignment. Here in this study, we report the presence of a minisatellite OsMin1 within this intron, where a 20(19)-bp repeat motif is duplicated two to six times in different isolates. Fourteen intron alleles and 13 OsMin1 alleles were identified among 125 O. sinensis samples distributed broadly on the Tibetan Plateau. Two OsMin1 alleles were prevalent, corresponding to either two or five repeats of the core sequence motif. OsMin1 appears to be a single locus marker in the O. sinensis genome, but its origin is undetermined. Abundant recombination signals were detected between upstream and downstream flanking regions of OsMin1, suggesting that OsMin1 mutate by unequal crossing over. Geographic distribution, fungal phylogeny, and host insect phylogeny all significantly affected intron distribution patterns but with the greatest influence noted for fungal genotypes and the least for geography. As far as we know, OsMin1 is the first minisatellite found in O. sinensis and the second found in fungal introns. OsMin1 may be useful in designing an efficient protocol to discriminate authentic O. sinensis from counterfeits. PMID:26754819

  13. Effect of an Antimicrobial Compound on Different Processes within the Oscillation of Min Proteins in E. coli Bacterial Cells

    Giuliani, Maximiliano; Dutcher, John

    2013-03-01

    A key step in the life of a bacterium is its division into two daughter cells of equal size. This process is carefully controlled and regulated so that equal partitioning of the cellular machinery is obtained. In E. coli, this regulation is accomplished, in part, by the Min protein system. The Min proteins undergo an oscillation between the poles of rod-shaped E. coli bacteria. We use high magnification, time-resolved total internal reflection fluorescence microscopy to characterize the temporal distributions of different processes within the oscillation: the MinD-MinE interaction time, the residence time for membrane bound MinD, and the recruitment time for MinD to be observed at the opposite pole. We also characterize the change in each of these processes in the presence of the antimicrobial compound polymyxin B (PMB). We show that the times corresponding to the removal of MinD from one pole and the recruitment of MinD at the opposite pole are correlated. We explain this correlation through the existence of a concentration threshold. The effect of PMB on the concentration threshold is used to identify which process within the oscillation is most affected.

  14. Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution.

    Schulze, Torben; Morsi, Mai; Brüning, Dennis; Schumacher, Kirstin; Rustenbeck, Ingo

    2016-03-01

    MIN6 cells and MIN6 pseudo-islets are popular surrogates for the use of primary beta cells and islets. Even though it is generally agreed that the stimulus-secretion coupling may deviate from that of beta cells or islets, direct comparisons are rare. The present side-by-side comparison of insulin secretion, cytosolic Ca(2+) concentration ([Ca(2+)] i ) and oxygen consumption rate (OCR) points out where similarities and differences exist between MIN6 cells and normal mouse beta cells. In mouse islets and MIN6 pseudo-islets depolarization by 40 mM KCl was a more robust insulinotropic stimulus than 30 mM glucose. In MIN6 pseudo-islets, but not in mouse islets, the response to 30 mM glucose was much lower than to 40 mM KCl and could be suppressed by a preceding stimulation with 40 mM KCl. In MIN6 pseudo-islets, glucose was less effective to raise [Ca(2+)] i than in primary islets. In marked contrast to islets, the OCR response of MIN6 pseudo-islets to 30 mM glucose was smaller than to 40 mM KCl and was further diminished by a preceding stimulation with 40 mM KCl. The same pattern was observed when MIN6 pseudo-islets were cultured in 5 mM glucose. As with insulin secretion memory effects on the OCR remained after wash-out of a stimulus. The differences between MIN6 cells and primary beta cells were generally larger in the responses to glucose than to depolarization by KCl. Thus, the use of MIN6 cells in investigations on metabolic signalling requires particular caution. PMID:26227244

  15. Examination of spatiotemporal gait parameters during the 6-min walk in individuals with multiple sclerosis.

    Socie, Michael J; Motl, Robert W; Sosnoff, Jacob J

    2014-12-01

    This investigation examined spatiotemporal parameters of gait during the 6-min walk (6MW) in individuals with multiple sclerosis (MS) and in healthy controls. Eighteen individuals with MS [divided into those who were independently ambulatory (n=10) and those who were ambulatory with assistance (n=8)] and 10 healthy controls performed a 6MW while recording spatiotemporal gait parameters using a pressure-sensitive walkway. Parameters recorded were walking velocity, cadence, step length and width, step time, percent of the gait cycle in double support, and variability of step length and width, step time, and double support. The ambulatory with assistance MS group had a significantly greater reduction in walking velocity (P=0.000) over the course of the 6MW, which coincided with a significantly greater increase in step time and double support (P=0.029) than in the other groups. Only the ambulatory with assistance MS group showed an increase in step-time variability and double-support variability during the 6MW (P's<0.05). The novel results indicate that the reduction in velocity over prolonged walking occurs through a greater change in the temporal parameters of gait in persons with MS who require assistance while walking. In addition, the increase in gait variability in the individuals with MS who require assistance while walking indicates that the control over walking further deteriorates over the course of the 6MW. PMID:25117855

  16. Development of 160 m3/min large capacity sodium-immersed self-cooled electromagnetic pump

    A large capacity sodium-immersed self-cooled electromagnetic pump (LEMP) was developed for application to the main circulation pumps of FBR. This advanced LEMP is a submergible annular linear induction pump designed to be self-cooled by immersing into sodium and applying high temperature electrical insulation. Almost all the internal electrical losses were transferred to the surrounding sodium, which can be recovered as electricity by turbine generators. The LEPM having specifications of 160m3/min flow rate, 0.28 MPa head and more than 40% efficiency at the rating was designed, fabricated and tested in the sodium pump test facility. The test involves magnetic field measurement in the air and a variety of sodium tests during 2.550h, which demonstrated good pump performance and flow controllability, and satisfied the design target. The boundary between flow stability and instability of the LEMP operation could be defined by peak position of the Q-H curve, which was specified by Rem x S (magnetic Reynolds' number times slip) of 1.4 to 1.5 at 335degC. Based on the test results, the applicability of the LEMP for the FBR was confirmed. (author)

  17. Max-Min Optimality of Service Rate Control in Closed Queueing Networks

    Xia, Li

    2013-04-01

    In this technical note, we discuss the optimality properties of service rate control in closed Jackson networks. We prove that when the cost function is linear to a particular service rate, the system performance is monotonic w.r.t. (with respect to) that service rate and the optimal value of that service rate can be either maximum or minimum (we call it Max-Min optimality); When the second-order derivative of the cost function w.r.t. a particular service rate is always positive (negative), which makes the cost function strictly convex (concave), the optimal value of such service rate for the performance maximization (minimization) problem can be either maximum or minimum. To the best of our knowledge, this is the most general result for the optimality of service rates in closed Jackson networks and all the previous works only involve the first conclusion. Moreover, our result is also valid for both the state-dependent and load-dependent service rates, under both the time-average and customer-average performance criteria.

  18. A Study of Min Gui, a Native of Huzhou%闵珪考略

    潘明福

    2011-01-01

    闵珪乃明代湖州籍名臣,一生屡按数省,四任刑官,平叛抚民。政绩卓著。为人刚直,治狱严正,为人所称道。依据相关典籍,勾勒闵珪的生平事迹,有助于更深入、更全面了解这位明代湖州籍名臣。%Min Gui, a native of Huzhou, was a famous official in the Ming Dynasty. In his life he was appointed as an official in several provinces and he was made an official in charge of penalty four times, suppressing rebels and helping the people with eminent achievements. He was upright and outspoken, and strict and just in governing the jail, so he was greatly respected and admired. This article, based on relative books and historical literatures, briefly tells about his life and deeds, which contributes to understand this famous official of Huzhou origin in a more profound and all round way.

  19. Monitoring the informational efficiency of European corporate bond markets with dynamical permutation min-entropy

    Zunino, Luciano; Bariviera, Aurelio F.; Guercio, M. Belén; Martinez, Lisana B.; Rosso, Osvaldo A.

    2016-08-01

    In this paper the permutation min-entropy has been implemented to unveil the presence of temporal structures in the daily values of European corporate bond indices from April 2001 to August 2015. More precisely, the informational efficiency evolution of the prices of fifteen sectorial indices has been carefully studied by estimating this information-theory-derived symbolic tool over a sliding time window. Such a dynamical analysis makes possible to obtain relevant conclusions about the effect that the 2008 credit crisis has had on the different European corporate bond sectors. It is found that the informational efficiency of some sectors, namely banks, financial services, insurance, and basic resources, has been strongly reduced due to the financial crisis whereas another set of sectors, integrated by chemicals, automobiles, media, energy, construction, industrial goods & services, technology, and telecommunications has only suffered a transitory loss of efficiency. Last but not least, the food & beverage, healthcare, and utilities sectors show a behavior close to a random walk practically along all the period of analysis, confirming a remarkable immunity against the 2008 financial crisis.

  20. Analysis of the spectra of geomagnetic variations having periods from 5 min to 4 hours

    The geomagnetic field variation spectra for the period range of 5 min to 4 hours were analyzed at 64 world observatories to discover systematic behavior in the spectral composition that could be associated with the time of day, season, solar cycle, activity level, component direction, and geographical location of the station. There was found no consistent frequency location for peaks in the spectral composition. Rather, the displays of spectral amplitudes A were mostly ''linear'' in form, often obeying A approximately T/sup m/, where T is the period. The spectral slope m was usually close to 1.0 but varied at times from 0.5 to 2.0. The amplitudes always showed a maximum at the auroral zone latitudes, a minimum near 20 to 400, and a minor maximum near the equator. The positions shifted equatorward with increasing activity. The relative growth in amplitude with rising activity varied with latitude. Seasonal peaks in activity were found at equinoctil months. A summertime minimum occurred at auroral zone stations; elsewhere a summertime enhancement occurred. General findings emphasizing the North American hemisphere and the year 1965 are presented in a number of tables and graphs

  1. A 210-min solid phase cytometry test for the enumeration of Escherichia coli in drinking water.

    Van Poucke, S O; Nelis, H J

    2000-09-01

    A 210-min-test for the enumeration of Escherichia coli in drinking water is described, based on solid phase cytometry (SPC) and a two-step enzymatic procedure for fluorescence labelling of single cells and small microcolonies. The test involves membrane filtration through a 25-mm black polyester filter, induction of beta-glucuronidase in the retained target cells, fluorescence labelling with fluorescein-di-beta-Dglucuronide as an enzyme substrate and laser scanning of the membrane filter. Scan results can be confirmed on-line by epifluorescence microscopy. Application to 149 naturally contaminated and uncontaminated well, tap, out-of-pump centre (distribution), surface and sewage-spiked water samples indicated > or =90% agreement and equivalence with plate count methods, including Chromocult Coliform agar and m FC agar. In 5.4% of all samples examined, SPC detected between 1 and 11 E. coli per 100 ml, while the two plate methods yielded negative results. Cases of a negative SPC result but a positive E. coli count on both reference media were not observed. This test would primarily be useful for 'emergency' monitoring of drinking water when rapid results are crucial. PMID:11021570

  2. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations.

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-01-01

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules. PMID:27554526

  3. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-01-01

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules. PMID:27554526

  4. Dopamine Receptor Signaling in MIN6 β-Cells Revealed by Fluorescence Fluctuation Spectroscopy.

    Caldwell, Brittany; Ustione, Alessandro; Piston, David W

    2016-08-01

    Insulin secretion defects are central to the development of type II diabetes mellitus. Glucose stimulation of insulin secretion has been extensively studied, but its regulation by other stimuli such as incretins and neurotransmitters is not as well understood. We investigated the mechanisms underlying the inhibition of insulin secretion by dopamine, which is synthesized in pancreatic β-cells from circulating L-dopa. Previous research has shown that this inhibition is mediated primarily by activation of the dopamine receptor D3 subtype (DRD3), even though both DRD2 and DRD3 are expressed in β-cells. To understand this dichotomy, we investigated the dynamic interactions between the dopamine receptor subtypes and their G-proteins using two-color fluorescence fluctuation spectroscopy (FFS) of mouse MIN6 β-cells. We show that proper membrane localization of exogenous G-proteins depends on both the Gβ and Gγ subunits being overexpressed in the cell. Triple transfections of the dopamine receptor subtype and Gβ and Gγ subunits, each labeled with a different-colored fluorescent protein (FP), yielded plasma membrane expression of all three FPs and permitted an FFS evaluation of interactions between the dopamine receptors and the Gβγ complex. Upon dopamine stimulation, we measured a significant decrease in interactions between DRD3 and the Gβγ complex, which is consistent with receptor activation. In contrast, dopamine stimulation did not cause significant changes in the interactions between DRD2 and the Gβγ complex. These results demonstrate that two-color FFS is a powerful tool for measuring dynamic protein interactions in living cells, and show that preferential DRD3 signaling in β-cells occurs at the level of G-protein release. PMID:27508444

  5. Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD.

    Waatevik, Marie; Johannessen, Ane; Gomez Real, Francisco; Aanerud, Marianne; Hardie, Jon Andrew; Bakke, Per Sigvald; Lind Eagan, Tomas Mikal

    2016-07-01

    The 6-min walk test (6MWT) is an exercise test that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on oxygen desaturation. We investigated oxygen desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline in lung function and decline in lean body mass.433 COPD patients were included in the Bergen COPD Cohort Study 2006-2009, and followed-up for 3 years. Patients were characterised using spirometry, bioelectrical impedance measurements, Charlson comorbidity score, exacerbation history, smoking and arterial blood gases. 370 patients completed the 6MWT at the baseline of the study. Information on all-cause mortality was collected in 2011.Patients who experienced oxygen desaturation during the 6MWT had an approximately twofold increased risk of death (hazard ratio 2.4, 95% CI 1.2-5.1), a 50% increased risk for experiencing later COPD exacerbations (incidence rate ratio 1.6, 95% CI 1.1-2.2), double the yearly rate of decline in both forced vital capacity and forced expiratory volume in 1 s (3.2% and 1.7% versus 1.7% and 0.9%, respectively) and manifold increased yearly rate of loss of lean body mass (0.18 kg·m(-2) versus 0.03 kg·m(-2) among those who did not desaturate).Desaturating COPD patients had a significantly worse prognosis than non-desaturating COPD patients, for multiple important disease outcomes. PMID:27076586

  6. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies.

    Kretschmer, Simon; Schwille, Petra

    2014-01-01

    For reconstruction of controlled cell division in a minimal cell model, or protocell, a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli, the Min proteins oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro, the Min proteins self-organize into spatiotemporal patterns in the presence of a lipid membrane and ATP. We review recent progress made in studying the Min system in vitro, particularly focusing on the effects of various physicochemical parameters and boundary conditions on pattern formation. Furthermore, we discuss implications and challenges for utilizing the Min system for division site placement in protocells. PMID:25513760

  7. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies

    Simon Kretschmer

    2014-12-01

    Full Text Available For reconstruction of controlled cell division in a minimal cell model, or protocell, a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli, the Min proteins oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro, the Min proteins self-organize into spatiotemporal patterns in the presence of a lipid membrane and ATP. We review recent progress made in studying the Min system in vitro, particularly focusing on the effects of various physicochemical parameters and boundary conditions on pattern formation. Furthermore, we discuss implications and challenges for utilizing the Min system for division site placement in protocells.

  8. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies

    Simon Kretschmer; Petra Schwille

    2014-01-01

    For reconstruction of controlled cell division in a minimal cell model, or protocell , a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli , the Min protein s oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro , the Min proteins self - organize into spatiotem poral patterns in the presence of a ...

  9. Promotion of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on titanium

    Xin-Yu Li

    2014-02-01

    Full Text Available AIM:To investigate the influence of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on titanium (Ti surface.METHODS:The chimeric peptide RKLPDAPRGDN (minTBP-1-PRGDN was synthesized by connecting RKLPDA (minTBP-1 to the N-terminal of PRGDN , the influence of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on Ti surface were tested using PRGDN and minTBP-1as controls. The keratocytes attached to the surface of Ti were either stained with FITC-labeled phalloidin and viewed with fluorescence microscope or quantified with alamar Blue method. The proliferation of keratocytes on Ti were quantified with 3-(4,5-dim- ethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide up-taking methods. The secretion of type I collagen were determined using an ELISA kit.RESULTS:The results showed that minTBP-1-PRGDN at a concentration of 100ng/mL was the most potent peptide to enhance the attachment of human keratocytes to the surface of Ti (1.40±0.03 folds, P=0.003, to promote the proliferation (1.26±0.05 folds, P=0.014 and the synthesis of type I collagen (1.530±0.128, P=0.008. MinTBP-1 at the same concentration could only promote the attachment (1.13±0.04 folds, P=0.020 and proliferation(1.15±0.06 folds, P=0.021, while PRGDN had no significant influence (P>0.05.CONCLUSION:Our data shows that the novel chimeric peptide minTBP-1-PRGDN could promote the attachment, proliferation and type I collagen synthesis of human keratocytes on the surface of Ti.

  10. New cross section data and review of production routes of medically used {sup 110m}In

    Tárkányi, F.; Takács, S. [Institute for Nuclear Research, Hungarian Academy of Sciences, H4026 Debrecen (Hungary); Ditrói, F., E-mail: ditroi@atomki.hu [Institute for Nuclear Research, Hungarian Academy of Sciences, H4026 Debrecen (Hungary); Hermanne, A. [Cyclotron Laboratory, Vrije Universiteit Brussel, B1050 Brussels (Belgium); Baba, M. [Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai 980-8578 (Japan); Mohsena, B.M.A. [Nuclear Research Center – Egyptian Atomic Energy Authority, Cairo (Egypt); Ignatyuk, A.V. [Institute of Physics and Power Engineering, 249020 Obninsk (Russian Federation)

    2015-05-15

    Highlights: •{sup 110m}In production cross sections and yields. •Stacked foil irradiation technique. •Comparison of experimental results with the ALICE, EMPIRE and TALYS theoretical model codes. •Proton, deuteron, {sup 3}He and alpha activations. -- Abstract: Evaluation of nuclear data for production routes of {sup 110m}In is in progress in the frame of an IAEA Coordinated Research Project (CRP). New experimental cross section data for the indirect {sup nat}In(p,x){sup 110}Sn-{sup 110m}In and for the direct {sup 107}Ag(α,n){sup 110m}In and {sup 109}Ag({sup 3}He,2n){sup 110m}In production routes and for the satellite impurity reactions {sup 107}Ag(α,xn){sup 110g,109}In and {sup 109}Ag({sup 3}He,xn){sup 110g,111,109}In have been measured by using the activation method, stacked foil irradiation technique and gamma-ray spectrometry. Additional data are reported for production of the {sup 111}In diagnostic gamma-emitter via the {sup 109}Ag(α,2n){sup 111}In reaction. The earlier experimental data were critically reviewed in order to prepare recommended data and optimal production parameters for the different routes.

  11. Inhibitory effects of low-dose aloe-emodin on the development of colorectal tumors in min mice.

    Shimpo, Kan; Chihara, Takeshi; Kaneko, Takaaki; Beppu, Hidehiko; Wakamatsu, Kazumasa; Shinzato, Masanori; Yukitake, Jun; Sonoda, Shigeru

    2014-01-01

    Aloe-emodin (AE), a natural anthraquinone compound, has been reported to exhibit anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. In the present study, we investigated the cancer chemopreventive effects of AE in an Apc-deficient Min mouse model. In the first experiment, male Min mice were fed a basal diet or diets containing 5 ppm AE and 10 ppm AE for 12 weeks. The dietary administration of 5 ppm AE significantly reduced the number of colorectal tumors. In a second experiment, we investigated the effects of AE on colitis-related colon carcinogenesis in Min mouse treated with dextran sodium sulfate (DSS). Female Min mice were administered 1% DSS in their drinking water for 7 days. AE was given to mice in their diet at a dose of 5 or 50 ppm for 5 weeks. Feeding with AE significantly reduced the number of colorectal tumors. When proliferation of cells in normal-appearing colonic mucosa was assessed by monoclonal anti-rat Ki-67 antibody (MIB-5) immunohistochemistry in experiments 1 and 2, the AE treatment significantly decreased the mean MIB-5-labeling index. These results suggest that the dietary administration of low-dose AE may have chemopreventive effects against development of colorectal tumors in Min mice, possibly in part by reducing cell proliferation in colorectal mucosa. PMID:25081669

  12. Measurement of left ventricular ejection fraction with ionic sup(113m)In and a cardiac probe

    Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope. Bios Inc., Valhalla, New York) and sup(113m)In in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects sup(99m)TC-RBCs were compared with sup(113m)In, which binds to transferrin after IV injection. With sup(99m)Tc-RBCs average LVEF was 57+-7% (1 SD); with sup(113m)In, average LEVF was 55+-8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEF's obtained using sup(99m)Tc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and sup(113m)In increased in 28 normals from 57+-9% to 64+-13% (P<0.001) during handgrip exercise, while the LVEF decreased from 45+-9% to 41+-10% (P<0.01) in patients with acute myocardial infarction 4-7 weeks after episode, from 48+-11 to 40+-12% (P<0.001) in patients with old myocardial infarction, and from 52+-9 to 42+-9% (P<0.001) in patients with angina pectoris. The cardiac probe and sup(113m)In provide a useful alternate means of determining left ventricular dysfunction in facilities where sup(99m)Tc and a gamma camera computer system are not readily available. (orig.)

  13. Measurement of left ventricular ejection fraction with ionic sup(113m)In and a cardiac probe

    Liu, X.; Harrison, K.S.; Wagner, H.N. Jr.

    1982-09-01

    Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope. Bios Inc., Valhalla, New York) and sup(113m)In in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects sup(99m)TC-RBCs were compared with sup(113m)In, which binds to transferrin after IV injection. With sup(99m)Tc-RBCs average LVEF was 57+-7% (1 SD); with sup(113m)In, average LEVF was 55+-8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEF's obtained using sup(99m)Tc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and sup(113m)In increased in 28 normals from 57+-9% to 64+-13% (P<0.001) during handgrip exercise, while the LVEF decreased from 45+-9% to 41+-10% (P<0.01) in patients with acute myocardial infarction 4-7 weeks after episode, from 48+-11 to 40+-12% (P<0.001) in patients with old myocardial infarction, and from 52+-9 to 42+-9% (P<0.001) in patients with angina pectoris. The cardiac probe and sup(113m)In provide a useful alternate means of determining left ventricular dysfunction in facilities where sup(99m)Tc and a gamma camera computer system are not readily available.

  14. Gynekologisen syövän sairastaneiden kokemuksia sairauden vaikutuksista seksuaalisuuteen ja minäkuvaan

    Liimatainen, Sanja; Hämäläinen, Tiia

    2015-01-01

    Gynekologinen syöpä ja sen hoidot vaikuttavat useimmiten merkittävästi naisen minäkuvaan ja seksuaalisuuteen. Sijainniltaan gynekologinen syöpä on lähellä seksuaalisuuteen liittyviä elimiä ja seksitoimintoja, jolloin sen merkitys seksuaalisuudelle korostuu. Sairauden tuomat mahdolliset muutokset vaikuttavat myös minäkuvaan, jolloin käsitykset itsestä useimmiten muokkaantuvat. Opinnäytetyön tarkoituksena oli kartoittaa sairauden merkityksellisyyttä ja sen mahdollisesti aiheuttamia vaikutuk...

  15. Mécanismes et verrous de la carbonatation minérale du CO2 en voie aqueuse

    Bonfils, Benjamin

    2012-01-01

    La carbonatation minérale est une technique alternative de capture et stockage du CO2 anthropique. L'abondance des matériaux carbonatables sur terre en fait une solution à fort potentiel. En particulier, la carbonatation directe en voie aqueuse a été présentée dans la littérature comme la voie la plus intéressante d'un point de vue énergétique pour la carbonatation minérale ex-situ, à la condition que les cinétiques naturellement lentes de dissolution des silicates magnésiens en phase aqueuse...

  16. Influence of min-a-zel plus and maize meal addition on the quality of lucerne silage

    Đorđević Nenad 1

    2004-01-01

    Full Text Available The influence of mineral adsorbent Min-A-Zel Plus (5 g/kg and maize meal (25 and 50 g/kg used alone or combined, on chemical composition, biochemical changes and quality of lucerne silage was investigated. Based on the obtained data, it can be concluded that addition of Min-A-Zel Plus reduces aminogenesis, while the use of maize meal alone or with zeolite favorable conditions are achieved for lactic acid fermentation, so that the quality of obtained silages is better by one quality class. To achieve better effects of silage quality, the use of combination of mineral adsorbent with carbohydrate additives is recommended.

  17. Miniature X-Ray Solar Spectrometer (MinXSS) - A Science-Oriented, University 3U CubeSat

    Mason, James P.; Woods, Thomas N.; Caspi, Amir; Chamberlin, Phillip C.; Moore, Christopher; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Palo, Scott; Solomon, Stanley

    2015-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat developed at the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado, Boulder (CU). Over 40 students contributed to the project with professional mentorship and technical contributions from professors in the Aerospace Engineering Sciences Department at CU and from LASP scientists and engineers. The scientific objective of MinXSS is to study processes in the dynamic Sun, from quiet-Sun to sol...

  18. Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture.

    David L Boucher

    Full Text Available As the field of molecular imaging evolves and increasingly is asked to fill the discovery and validation space between basic science and clinical applications, careful consideration should be given to the models in which studies are conducted. The MIN-O mouse model series is an established in vivo model of human mammary precancer ductal carcinoma in situ with progression to invasive carcinoma. This series of transplant lines is propagated in vivo and experiments utilizing this model can be completed in non-engineered immune intact FVB/n wild type mice thereby modeling the tumor microenvironment with biological relevance superior to traditional tumor cell xenografts. Unfortunately, the same qualities that make this and many other transplant lines more biologically relevant than standard cell lines for molecular imaging studies present a significant obstacle as somatic genetic re-engineering modifications common to many imaging applications can be technically challenging. Here, we describe a protocol for the efficient lentiviral transduction of cell slurries derived from precancerous MIN-O lesions, in vitro culture of "MIN-O-spheres" derived from single cell clones, and the subsequent transplantation of these spheres to produce transduced sublines suitable for optical imaging applications. These lines retain the physiologic and pathologic properties, including multilineage differentiation, and complex microanatomic interaction with the host stroma characteristic of the MIN-O model. We also present the in vivo imaging and immunohistochemical analysis of serial transplantation of one such subline and detail the progressive multifocal loss of the transgene in successive generations.

  19. Influence of Caffeine Ingestion on Perceived Mood States, Concentration, and Arousal Levels during a 75-Min University Lecture

    Peeling, Peter; Dawson, Brian

    2007-01-01

    This investigation aimed to assess the effect of a caffeine supplement on perceived mood state, concentration, and arousal during a 75-min university lecture. Methods. This randomized, blind, cross-over design investigation ran over a course of 2 consecutive weeks. During "week" 1, 10 third-year Human Movement and Exercise Science students were…

  20. Theoretical study on superconductivity in CeMIn{sub 5} (M = Co, Rh, Ir): pairing symmetry and pressure dependence

    Tanaka, Kazunori [Department of Physics, Faculty of Science and Technology, Tokyo University of Science, Noda 278-8510, Chiba (Japan); Ikeda, Hiroaki [Department of Physics, Kyoto University, Kyoto 606-8502, Kyoto (Japan); Nisikawa, Yunori [Department of Material Science, Osaka City University, Osaka 558-8585, Osaka (Japan); Yamada, Kosaku [Faculty of Science and Engineering, Ritsumeikan University, Kusatsu 525-8577, Siga (Japan)

    2007-10-10

    We study theoretically heavy fermion superconductors CeMIn{sub 5} (M = Co, Rh, Ir). CeCoIn{sub 5} and CeIrIn{sub 5} that become superconducting at ambient pressure with T{sub c} = 2.3 K and 0.4 K, respectively. On the other hand, CeRhIn{sub 5} is an antiferromagnet at ambient pressure and becomes superconducting under pressures greater than 1.6 GPa. With regards to the superconductivity, the existence of line nodes is indicated by nuclear-quadrupole-resonance (NQR), thermal conductivity, specific heat and electrical resistivity measurements. However, the pairing symmetry between d{sub x{sup 2}-y{sup 2}} and d{sub xy} is controversial. Therefore, we investigate the gap structure of CeMIn{sub 5} by a detailed calculation. We introduce a three-dimensional periodic Anderson model (3D-PAM) in order to reproduce the band characteristics of CeMIn{sub 5}. Thus, we identify the gap structure of CeMIn{sub 5} as the d{sub x{sup 2}-y{sup 2}} symmetry by solving the Eliashberg equations. In addition, we discuss the pressure dependence of T{sub c} and show that two factors determine T{sub c}. One factor is the momentum dependence of quasi-particle interaction and the other factor is the wavefunction renormalization factor. Thus, we have explained the superconductivity in CeMIn{sub 5} using the Fermi liquid theory.

  1. Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice

    Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, ApcMin/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. In Experiments 1 and 2, five-week old female ApcMin/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. In the ApcMin/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In ApcMin/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors. These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in ApcMin/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism

  2. Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2−/− ApcMin/+ Mouse ▿

    Nagamine, Claude M; Sohn, Jane J.; Rickman, Barry H.; Rogers, Arlin B.; Fox, James G.; Schauer, David B.

    2008-01-01

    Adenomatous polyposis coli (APC) mutations are linked to human and mouse colorectal cancers. The Apc multiple intestinal neoplasia (Min) mouse mutation causes adenomas to develop throughout the small and large intestines. The BALB-Min (C.B6-ApcMin/+) congenic strain was generated by backcrossing into BALB/c the ApcMin allele from C57BL/6J-ApcMin/+ mice. BALB-Min mice have a low tumor multiplicity (27.4 small intestine tumors/mouse) and a relatively long life span (>1 year) that makes them ame...

  3. A facile synthesis of MInSe2 (M = Cu, Ag) via low temperature pyrolysis of single source molecular precursors, [(R3P)2MIn(SeCOAr)4

    Shamik Ghoshal; Liladhar B Kumbhare; Vimal K Jain; Gautam K Dey

    2007-04-01

    The reaction of KSeCOAr with InCl3 and [MCl(PR3)2] in benzene afforded bimetallic complexes, [(R3P)2MIn(SeCOAr)4] (PR3 = PEt3 or PPh3; M = Cu or Ag; Ar = –C6H5 (phenyl) or 4-MeC6H4 (tolyl)). The triethylphosphine complexes decomposed rapidly when M = Ag while slowly when M = Cu. All these complexes were characterized by elemental analysis, IR, UV-VIS, NMR (1H, 31P) spectral data. Pyrolysis in a furnace at 300°C gave tetragonal MInSe2 (M = Cu, Ag) structure. Solvothermal decomposition of [(PPh3)2CuIn(SeCOAr)4] in boiling ethylene glycol gave nanorods of CuInSe2 which were characterized by XRD, EDAX, SEM and TEM.

  4. Science Goals and First Light Analysis from the Miniature X-ray Solar Spectrometer (MinXSS) CubeSat

    Caspi, Amir; Woods, Thomas N.; Warren, Harry; Chamberlin, Phillip C.; Jones, Andrew; Mason, James; McTiernan, James; Moore, Christopher; Palo, Scott; Solomon, Stanley

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3U CubeSat with deployment from the ISS planned in Q2 2016. Its goal is to measure the solar soft X-ray (SXR) spectral irradiance, an observational signature of hot plasma in the solar corona. Over the last few decades, there have been very few spectrally resolved observations from ~0.2 to ~4 keV (~0.3-6 nm). This range is sensitive to high-temperature plasma and contains many spectral lines (e.g., Mg, Si, Fe, S, Ar), the abundances of which probe plasma transport and provide valuable constraints on plasma heating mechanisms during both flares and quiescence. This solar SXR emission is primarily absorbed in the E-region of Earth's ionosphere, and the subsequently driven dynamical processes are still poorly understood, in large part because the energy distribution of the incident SXRs is not yet well characterized.MinXSS flies a miniature commercial off-the-shelf soft X-ray (SXR) spectrometer, the Amptek X123-SDD. The silicon drift detector has 0.5 mm fully depleted thickness and a 25 mm^2 physical area, with a ~16 micron Be entrance window; with on-board thermoelectric cooling and pulse pile-up rejection, it is sensitive to solar SXRs from ~0.5 to 30 keV with ~0.15 keV FWHM resolution. MinXSS also includes a broadband SXR photometer, providing an integrated intensity over a similar energy range for comparison, cross-calibration, and additional data, especially useful during more intense flares at the upper end of the X123 dynamic range.We present the MinXSS science goals for studying hot plasma in the solar corona, including impulsive flare heating and quiescent coronal heating, and the impact of the resultant SXR emission on Earth's ionosphere, thermosphere, and mesosphere. We present analysis of MinXSS first light results (depending on deployment date from the ISS), as well as modeling and predictions of future observations over the MinXSS 6-12 month mission lifetime.

  5. Polynomial Time Algorithm for Determining Max-Min Paths in Networks and Solving Zero Value Cyclic Games

    Dmitrii D. Lozovanu

    2005-10-01

    Full Text Available We study the max-min paths problem, which represents a game version of the shortest and the longest paths problem in a weighted directed graph. In this problem the vertex set V of the weighted directed graph G=(V,E is divided into two disjoint subsets VA and VB which are regarded as positional sets of two players. The players are seeking for a directed path from the given starting position ν 0 to the final position ν f , where the first player intends to maximize the integral cost of the path while the second one has aim to minimize it. Polynomial-time algorithm for determining max-min path in networks is proposed and its application for solving zero value cyclic games is developed. Mathematics Subject Classification 2000: 90B10, 90C35, 90C27.

  6. Min-max optimization and the radial approach to the public service system design with generalized utility

    Jaroslav Janáček

    2016-04-01

    Full Text Available The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enormous computational times or extreme memory demands when resolving this issue, we suggested and compared several approaches based on a bisection process with the purpose of developing an effective max-min approach to the public service system design with a generalized utility.

  7. Iterative l1-min algorithm for fixed pattern noise removal in fiber-bundle-based endoscopic imaging.

    Liu, Xuan; Zhang, Lijun; Kirby, Mitchell; Becker, Richard; Qi, Shaohai; Zhao, Feng

    2016-04-01

    In this study, we developed a signal processing method for fixed pattern noise removal in fiber-bundle-based endoscopic imaging. We physically acquired the fixed pattern of the fiber bundle and used it as a prior image in an l1 norm minimization (l1-min) algorithm. We chose an iterative shrinkage thresholding algorithm for l1 norm minimization. In addition to fixed pattern noise removal, this method also improved image contrast while preserving spatial resolution. The effectiveness of this method was demonstrated on images obtained from a dark-field illuminated reflectance fiber-optic microscope (DRFM). The iterative l1-min algorithm presented in this paper, in combination with the DRFM system that we previously developed, enables high-resolution, high-sensitivity, intrinsic-contrast, and in situ cellular imaging which has great potential in clinical diagnosis and biomedical research. PMID:27140773

  8. EFFECTS OF GENDER ON STROKE RATES, CRITICAL SPEED AND VELOCITY OF A 30-MIN SWIM IN YOUNG SWIMMERS

    Camila C. Greco; Pelarigo, Jailton G.; Figueira, Tiago R.; Benedito S. Denadai

    2007-01-01

    Our objective was to analyze the effect of gender on the relationship between stroke rates corresponding to critical speed (SRCS) and maximal speed of 30 min (SRS30) in young swimmers. Twenty two males (GM1) (Age = 15.4 ± 2.1 yr., Body mass = 63.7 ± 12.9 kg, Stature = 1.73 ± 0.09 m) and fourteen female (GF) swimmers (Age = 15.1 ± 1.6 yr., Body mass = 58.3 ± 8.8 kg, Stature = 1.65 ± 0.06 m) were studied. A subset of males (GM2) was matched to the GF by their velocity for a 30 min swim (S30). T...

  9. Quantitative inner membrane proteome datasets of the wild-type and the Δmin mutant of Escherichia coli.

    Liang, Suh-Yuen; Lin, Shu-Yu; Chiang, I-Chen; Shih, Yu-Ling

    2016-09-01

    This article presents data that were obtained through measuring the impact of the Min oscillation on membrane proteins in Escherichia coli by quantitative protemoics analysis. We isolated inner membranes from the wild-type and mutant strains to generate proteomics datasets based on NanoLC-nanoESI-MS/MS mass spectrometry using the isobaric tags for relative and absolute quantitation (iTRAQ) method. The datasets included the raw spectral files from four sample replicates and the processed files using Proteome Discoverer that contained a total of 40,072 MS/MS spectra with confident peptide identifier (FDRmembrane proteome of unique proteins with quantitation. Proteins of interest, that show significant difference in protein abundance of the mutant membrane, were isolated through statistical filtering. The data is related to "Quantitative proteomics analysis reveals the Min system of Escherichia coli modulates reversible protein association with the inner membrane" (Lee et al., 2016 [1]). PMID:27331106

  10. Experimental and Monte Carlo study on production of 110mIn via natCd(p,xn) reaction

    110mIn with 69.1 min half-life was produced by proton bombardment on natural cadmium. The target was prepared by electroplating technique. To reach a high activity product, the optimum energy range of the irradiation was selected to be 15-5 MeV via theoretical calculation. Radiochemical separation of cadmium and indium was carried out by extraction method. It yielded 44.3 ± 8.8 GBq C-1 after 1 hour irradiation by 100 μA current. On the other hand, the production route was simulated using MCNPX and the production yield was estimated with a reasonable agreement compared to the measured and literature data. (author)

  11. Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis

    Lin, Xiaojie; Huang, Zhimin; Liu, Juan; Li, Hai; Wei, Guohong; Cao, Xiaopei; Li, Yanbing

    2014-01-01

    Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β-cell treated with palmitate. Nevertheless, the underlying detailed mechanism is largely unknown. Here, we showed that miR-34a was significantly induced in Min6 pancreatic β-cell upon palmitate treatment. Elevated miR-34a promoted Min6 cell apoptosis. Intriguingly, ectopic expression of miR-34a lowered the expression of Bcl-2, an antiapoptotic protein. Luciferase reporter assay indicated the direct interaction of miR-34a with the Bcl-2 3′-UTR. Moreover, downregulated expression of Bcl-2 induced by palmitate could be restored by inhibition of miR-34a. We conclude that direct suppression of Bcl-2 by miR-34a accounts for palmitate-induced increased apoptosis rate in pancreatic β-cell. PMID:24829923

  12. Min Morfars Film

    Juel, Henrik

    1957-01-01

    Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film.......Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film....

  13. Se min pizzabolle!

    Hoffmeyer, Mikkeline; Brandt, Karen Merete

    2014-01-01

    Emne: Hvordan kan vi udvikle digitale læringsdesigns, der styrker visuelle, sproglige, æstetiske og kommunikative kompetencer i fagene dansk og billedkunst? Metode og baggrund: Ovenstående har været omdrejningspunkt i vores udviklingsarbejde, som har haft afsæt i sociosemiotisk forskning omkring ...

  14. Se min kropsholder

    Hansen, Lone Koefoed; Staunsager, Sara

    2015-01-01

    Også kønnet kan være en forandringsagent. Med stolen Hustruen som konkret metafor diskuterer artiklen, hvordan den kvindelige designforening Rundkant tager strategisk og kunstnerisk afsæt i kvindekampens og kvindekønnets historie og samtid, når medlemmerne søger at mestre kunsten som ung (kvindel...

  15. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice1

    Janakiram, Naveena B; Mohammed, Altaf; Qian, Li; Choi, Chang-In; Steele, Vernon E.; Rao, Chinthalapally V.

    2012-01-01

    Retinoid X receptor (RXR) has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics). Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. ...

  16. A Comparison of the Generalized minC Combination and the Hybrid DSm Combination Rules. Chapter 4

    Daniel, Milan

    Rehoboth : American Research Press, 2006 - (Smarandache, F.; Dezert, J.), s. 113-129 ISBN 1-59973-000-6 R&D Projects: GA AV ČR 1ET100300419 Institutional research plan: CEZ:AV0Z10300504 Keywords : belief function * combination of belief functions * Dempster-Shafer theory * conflict * minC combination * DSm theory * DSm combination rule Subject RIV: BA - General Mathematics

  17. Min-max optimization and the radial approach to the public service system design with generalized utility

    Jaroslav Janáček; Marek Kvet

    2016-01-01

    The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enor...

  18. Assessment of aortitis by semiquantitative analysis of 180-min 18F-FDG PET/CT acquisition images

    The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting. This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). 18F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of 18F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUVmax) (T), the lumen SUVmax (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population. The mean aortic wall SUVmax was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p max (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100 %, specificity 94.4 %). Semiquantitative analysis of PET/CT images acquired 180 min after 18F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting. (orig.)

  19. Assessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing.

    Hargreaves, Adam D; Mulley, John F

    2015-01-01

    Portable DNA sequencers such as the Oxford Nanopore MinION device have the potential to be truly disruptive technologies, facilitating new approaches and analyses and, in some cases, taking sequencing out of the lab and into the field. However, the capabilities of these technologies are still being revealed. Here we show that single-molecule cDNA sequencing using the MinION accurately characterises venom toxin-encoding genes in the painted saw-scaled viper, Echis coloratus. We find the raw sequencing error rate to be around 12%, improved to 0-2% with hybrid error correction and 3% with de novo error correction. Our corrected data provides full coding sequences and 5' and 3' UTRs for 29 of 33 candidate venom toxins detected, far superior to Illumina data (13/40 complete) and Sanger-based ESTs (15/29). We suggest that, should the current pace of improvement continue, the MinION will become the default approach for cDNA sequencing in a variety of species. PMID:26623194

  20. Transfer of a eubacteria-type cell division site-determining factor CrMinD gene to the nucleus from the chloroplast genome in Chlamydomonas reinhardtii

    LIU WeiZhong; HU Yong; ZHANG RunJie; ZHOU WeiWei; ZHU JiaYing; LIU XiangLin; HE YiKun

    2007-01-01

    MinD is a ubiquitous ATPase that plays a crucial role in selection of the division site in eubacteria, chloroplasts, and probably Archaea. In four green algae, Mesostigma viride, Nephroselmis olivacea, Chlorella vulgaris and Prototheca wickerhamii, MinD homologues are encoded in the plastid genome. However, in Arabidopsis, MinD is a nucleus-encoded, chloroplast-targeted protein involved in chloroplast division, which suggests that MinD has been transferred to the nucleus in higher land plants. Yet the lateral gene transfer (LGT) of MinD from plastid to nucleus during plastid evolution remains poorly understood. Here, we identified a nucleus-encoded MinD homologue from unicellular green alga Chlamydomonas reinhardtii, a basal species in the green plant lineage. Overexpression of CrMinD in wild type E. coli inhibited cell division and resulted in the filamentous cell formation, clearly demonstrated the conservation of the MinD protein during the evolution of photosynthetic eukaryotes. The transient expression of CrMinD-egfp confirmed the role of CrMinD protein in the regulation of plastid division. Searching all the published plastid genomic sequences of land plants, no MinD homologues were found, which suggests that the transfer of MinD from plastid to nucleus might have occurred before the evolution of land plants.

  1. Molecular Cloning, Expression of minD Gene from Lactobacillus acidophilus VTCC-B-871 and Analyses to Identify Lactobacillus rhamnosus PN04 from Vietnam Hottuynia cordata Thunb.

    Nguyen, Tu Hoang Khue; Doan, Vinh Thi Thanh; Ha, Ly Dieu; Nguyen, Huu Ngoc

    2013-01-01

    The minD gene encoding an inhibitor cell division MinD homolog from Lactobacillus acidophilus VTCC-B-871 was cloned. We showed that there were 97 % homology between minD genes of L. acidophilus VTCC-B-871 and Lactobacillus rhamnosus GG and Lactobacillus rhamnosus Lc705. Based on the analysis of the DNA sequence data from the L. rhamnosus genome project and sequenced minD gene of L. acidophilus VTCC-B-871, a pair of primers was designed to identified the different minD genes from L. acidophilu...

  2. The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+ mouse.

    James P White

    Full Text Available Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the Apc(Min/+ mouse is not known. Cachexia progression was studied in Apc(Min/+ mice that were either weight stable (WS or had initial (≤5%, intermediate (6-19%, or extreme (≥20% body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172, AMPK activity, and raptor phosphorylation (Ser 792 were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process.

  3. Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.

    Tai, William Chi-Shing; Wong, Wing-Yan; Lee, Magnolia Muk-Lan; Chan, Brandon Dow; Lu, Cheng; Hsiao, Wen-Luan Wendy

    2016-05-01

    Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. However, the underlying mechanisms remain unclear. In this study, we used the Apc(Min) (/+) colorectal cancer (CRC) mouse model to investigate the anti-cancer effect of GpS and we demonstrated that GpS treatment could significantly reduce the number and size of intestinal polyps in Apc(Min) (/+) mice. In order to identify the potential targets and mechanisms involved, a comparative proteomics analysis was performed and 40 differentially expressed proteins after GpS treatment were identified. Bioinformatics analyses suggested a majority of these proteins were involved in processes related to cellular redox homeostasis, and predicted Raf-1 as a potential target of GpS. The upregulation of two proteins known to be involved in redox homeostasis, peroxiredoxin-1 (Prdx1) and peroxiredoxin-2 (Prdx2), and the downregulation of Raf-1 were validated using Western blot analysis. After further investigation of the associated signaling networks, we postulated that the anti-cancer effect of GpS was mediated through the upregulation of Prdx1 and Prdx2, suppression of Ras, RAF/MEK/ERK/STAT, PI3K/AKT/mTOR signaling and modulation of JNK/p38 MAPK signaling. We also examined the potential combinatorial effect of GpS with the chemotherapeutic 5-fluorouracil (5-FU) and found that GpS could enhance the anti-cancer efficacy of 5-FU, further suppressing the number of polyps in Apc(Min/+) mice. Our findings highlight the potential of GpS as an anti-cancer agent, the potential mechanisms of its anti-cancer activities, and its effect as an adjuvant of 5-FU in the chemotherapy of CRC. PMID:26970558

  4. Assessment of aortitis by semiquantitative analysis of 180-min {sup 18}F-FDG PET/CT acquisition images

    Martinez-Rodriguez, Isabel [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Hospital Universitario Marques de Valdecilla, S. Medicina Nuclear, Santander (Spain); Martinez-Amador, N.; Banzo, I.; Quirce, R.; Jimenez-Bonilla, J.; Arcocha-Torres, M. de; Ibanez-Bravo, S.; Lavado-Perez, C.; Bravo-Ferrer, Z.; Carril, J.M. [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Blanco, R.; Gonzalez-Gay, M.A. [University of Cantabria, Department of Rheumatology, Marques de Valdecilla University Hospital, Santander (Spain)

    2014-12-15

    The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting. This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). {sup 18}F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of {sup 18}F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUV{sub max}) (T), the lumen SUV{sub max} (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population. The mean aortic wall SUV{sub max} was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p < 0.0001). The TBR was 1.66 ± 0.26 for patients with aortitis and 1.24 ± 0.08 for patients without aortitis (p < 0.0001). The differences were also statistically significant when the patients with aortitis and controls were compared. Receiver-operating characteristic (ROC) analysis revealed that the area under the curve was greater for the TBR than for the aortic wall SUV{sub max} (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100 %, specificity 94.4 %). Semiquantitative analysis of PET/CT images acquired 180 min after {sup 18}F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting. (orig.)

  5. Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation

    Michele Barone

    2015-01-01

    Full Text Available We explored the hypothesis that an altered microenvironment (intestinal adenomatous polyp could modify the differentiation program of bone marrow-derived stem cells (BMSCs, involving them in colon carcinogenesis. Sublethally irradiated 8-week-old female ApcMin/+ mice were transplanted with bone marrow (BM cells obtained from either male age-matched ApcMin/+ (Apc-Tx-Apc or wild type (WT (WT-Tx-Apc mice. At 4 and 7 weeks after transplantation, BM-derived colonocytes were recognized by colocalization of Y-chromosome and Cdx2 protein (specific colonocyte marker. Polyp number, volume, and grade of dysplasia were not influenced by irradiation/transplantation procedures since they were similar in both untreated female ApcMin/+ and Apc-Tx-Apc mice. At 4 and 7 weeks after transplantation, a progressive significant reduction of polyp number and volume was observed in WT-Tx-Apc mice. Moreover, the number of WT-Tx-Apc mice with a high-grade dysplastic polyps significantly decreased as compared to Apc-Tx-Apc mice. Finally, at 4 and 7 weeks after transplantation, WT-Tx-Apc mice showed a progressive significant increase of Y+/Cdx2+ cells in “normal” mucosa, whereas, in the adenomatous tissue, Y+/Cdx2+ cells remained substantially unvaried. Our findings demonstrate that WT BMSCs do not participate in polyp development but rather inhibit their growth. The substitution of genotypically altered colonocytes with Y+/Cdx2+ cells probably contributes to this process.

  6. Amîra al-mü’minîn: Zubeyde Bint Ja'far

    KAN, Kadir

    2011-01-01

    This article deals with Zubeyde bint Ja'far who was Harun al-Rashid’s wife and one of the most influential women of Abbasid era, Zubeyde bint Ja'far, and her place in the early Abbasid political life. Zubeyde was the only women who gave birth to a caliph from the Abbasid-Hashemite lineage. Unlike the wives of the other caliphs, she was called “amîra al-mü’minîn” and had an important effect on her husband, Harun al-Rashid and the Abbasid state administration. She had a significant place in the...

  7. The effects of initial conditions and control time on optimal actuator placement via a max-min Genetic Algorithm

    Redmond, J. [Sandia National Labs., Albuquerque, NM (United States); Parker, G. [State Univ. of New York, Buffalo, NY (United States)

    1993-07-01

    This paper examines the role of the control objective and the control time in determining fuel-optimal actuator placement for structural vibration suppression. A general theory is developed that can be easily extended to include alternative performance metrics such as energy and time-optimal control. The performance metric defines a convex admissible control set which leads to a max-min optimization problem expressing optimal location as a function of initial conditions and control time. A solution procedure based on a nested Genetic Algorithm is presented and applied to an example problem. Results indicate that the optimal locations vary widely as a function of control time and initial conditions.

  8. Recuperação de lítio de minérios portugueses de lepidolite

    Nogueira, C. A.

    2011-01-01

    Neste artigo são apresentados de forma sumária alguns resultados dos trabalhos de investigação realizados no LNEG (e ex-INETI) sobre o desenvolvimento de processos de recuperação metalúrgica de lítio de minérios pegmatíticos de lepidolite. Foram estudadas e testadas várias tecnologias como a calcinação seguida de digestão ácida, e a lixiviação carbonatante sob pressão, tendo esta última permitido produzir carbonato de lítio de boa pureza.

  9. Introduction of MKZP (Min Ku Zirconium Process) as an alternative to pyroprocessing for used nuclear fuel management

    A new process to co-recover uranium and transuranic nuclides from used nuclear fuels was introduced, which was named 'MKZP' (Min Ku Zirconium Process), as an alternative of widely known pyroprocessing. Instead of an electrochemical reduction of the pyroprocessing, the MKZP employs Zr and ZrCl4 as reactants to chemically convert U3O8 into UCl3, which leads to a significant advantage in total number of processes. An addition of fresh zirconium can be minimized by employing cladding hull waste as a source of zirconium tetrachloride through a chlorination process. (author)

  10. Miniature X-Ray Solar Spectrometer (MinXSS) - A Science-Oriented, University 3U CubeSat

    Mason, James P; Caspi, Amir; Chamberlin, Phillip C; Moore, Christopher; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Palo, Scott; Solomon, Stanley

    2015-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat developed at the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado, Boulder (CU). Over 40 students contributed to the project with professional mentorship and technical contributions from professors in the Aerospace Engineering Sciences Department at CU and from LASP scientists and engineers. The scientific objective of MinXSS is to study processes in the dynamic Sun, from quiet-Sun to solar flares, and to further understand how these changes in the Sun influence the Earth's atmosphere by providing unique spectral measurements of solar soft x-rays (SXRs). The enabling technology providing the advanced solar SXR spectral measurements is the Amptek X123, a commercial-off-the-shelf (COTS) silicon drift detector (SDD). The Amptek X123 has a low mass (~324 g after modification), modest power consumption (~2.5 W), and small volume (2.7" x 3.9" x 1.0"), making it ideal for a CubeSat. This paper provides an overvi...

  11. Estimation of 5-min time-step data of tilted solar global irradiation using ANN (Artificial Neural Network) model

    Converting measured horizontal global solar irradiance in tilted ones is a difficult task, particularly for a small time-step and for not-averaged data. Conventional methods (statistical, correlation, …) are not always efficient with time-step less than one hour; thus, we want to know if an ANN (Artificial Neural Network) is able to realize this conversion with a good accuracy when applied to 5-min solar radiation data of Bouzareah, Algeria. The ANN is developed and optimized using two years of solar data; the nRMSE (relative root means square error) is around 8% for the optimal configuration, which corresponds to a very good accuracy for such a short time-step. - Highlights: • ANN (Artificial Neural Network) methodology applied to 5-min global solar irradiation in order to estimate tilted irradiations. • Model validation with more than 75,000 data. • 8.81% for the RMSE (root means square error) and around 6.63% for the nMAE (normalized mean absolute error). • Solar radiation models with such a fine time step are rare

  12. Analyzing Sub-Threshold Bitcell Topologies and the Effects of Assist Methods on SRAM VMIN

    James Boley

    2012-04-01

    Full Text Available The need for ultra low power circuits has forced circuit designers to scale voltage supplies into the sub-threshold region where energy per operation is minimized [1]. The problem with this is that the traditional 6T SRAM bitcell, used for data storage, becomes unreliable at voltages below about 700 mV due to process variations and decreased device drive strength [2]. In order to achieve reliable operation, new bitcell topologies and assist methods have been proposed. This paper provides a comparison of four different bitcell topologies using read and write VMIN as the metrics for evaluation. In addition, read and write assist methods were tested using the periphery voltage scaling techniques discussed in [4–13]. Measurements taken from a 180 nm test chip show read functionality (without assist methods down to 500 mV and write functionality down to 600 mV. Using assist methods can reduce both read and write VMIN by 100 mV over the unassisted test case.

  13. Influence of Forecast Accuracy of Photovoltaic Power Output on Capacity Optimization of Microgrid Composition under 30 min Power Balancing Control

    Sone, Akihito; Kato, Takeyoshi; Shimakage, Toyonari; Suzuoki, Yasuo

    A microgrid (MG) is one of the measures for enhancing the high penetration of renewable energy (RE)-based distributed generators (DGs). If a number of MGs are controlled to maintain the predetermined electricity demand including RE-based DGs as negative demand, they would contribute to supply-demand balancing of whole electric power system. For constructing a MG economically, the capacity optimization of controllable DGs against RE-based DGs is essential. By using a numerical simulation model developed based on a demonstrative study on a MG using PAFC and NaS battery as controllable DGs and photovoltaic power generation system (PVS) as a RE-based DG, this study discusses the influence of forecast accuracy of PVS output on the capacity optimization. Three forecast cases with different accuracy are compared. The main results are as follows. Even with no forecast error during every 30 min. as the ideal forecast method, the required capacity of NaS battery reaches about 40% of PVS capacity for mitigating the instantaneous forecast error within 30 min. The required capacity to compensate for the forecast error is doubled with the actual forecast method. The influence of forecast error can be reduced by adjusting the scheduled power output of controllable DGs according to the weather forecast. Besides, the required capacity can be reduced significantly if the error of balancing control in a MG is acceptable for a few percentages of periods, because the total periods of large forecast error is not so often.

  14. Statistical properties of superflares on solar-type stars based on the Kepler 1-min cadence data

    Maehara, Hiroyuki; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    2016-01-01

    We searched for superflares on solar-type stars using the Kepler short-cadence (1-min sampling) data in order to detect superflares with short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of $10^{32}$ erg to $10^{36}$ erg. Using these new data combined with the results from the data with 30-min sampling, we found the occurrence frequency ($dN/dE$) of superflares as a function of flare energy ($E$) shows the power-law distribution ($dN/dE \\propto E ^{-\\alpha}$) with $\\alpha=1.5$ for $10^{33}

  15. Un cas de leishmaniose féline disséminée dans le sud de la France

    Pocholle, E.; Reyes-Gomez, E.; Giacomo, A.; Delaunay, P.; Hasseine, L.; Marty, P.

    2012-01-01

    Cet article rapporte un cas de leishmaniose féline disséminée chez un chat (Felis catus) de 14 ans, séropositif pour le FIV et vivant dans les Alpes-Maritimes (sud de la France). Le chat présente des papules érythémateuses ulcérées sur la face et l’encolure, et une lésion proliférative ulcérée sur l’oreille gauche. C’est l’examen histopathologique des lésions cutanées qui permet le diagnostic d’une leishmaniose disséminée, associée à un carcinome épidermoïde de l’oreille. 100 mg d’allopurinol administrés une fois par jour per os pendant quatre mois ont permis la rémission totale des lésions cutanées. Des prélèvements post mortem ont révélé la persistance du parasite dans l’organisme après six mois de traitement. Cet article discute de la sensibilité du chat à la leishmaniose et de son rôle potentiel de réservoir. PMID:22314243

  16. EMAG2: A 2-arc min resolution Earth Magnetic Anomaly Grid compiled from satellite, airborne, and marine magnetic measurements

    Maus, S.; Barckhausen, U.; Berkenbosch, H.; Bournas, N.; Brozena, J.; Childers, V.; Dostaler, F.; Fairhead, J.D.; Finn, C.; von Frese, R.R.B; Gaina, C.; Golynsky, S.; Kucks, R.; Lu, Hai; Milligan, P.; Mogren, S.; Muller, R.D.; Olesen, O.; Pilkington, M.; Saltus, R.; Schreckenberger, B.; Thebault, E.; Tontini, F.C.

    2009-01-01

    A global Earth Magnetic Anomaly Grid (EMAG2) has been compiled from satellite, ship, and airborne magnetic measurements. EMAG2 is a significant update of our previous candidate grid for the World Digital Magnetic Anomaly Map. The resolution has been improved from 3 arc min to 2 arc min, and the altitude has been reduced from 5 km to 4 km above the geoid. Additional grid and track line data have been included, both over land and the oceans. Wherever available, the original shipborne and airborne data were used instead of precompiled oceanic magnetic grids. Interpolation between sparse track lines in the oceans was improved by directional gridding and extrapolation, based on an oceanic crustal age model. The longest wavelengths (>330 km) were replaced with the latest CHAMP satellite magnetic field model MF6. EMAG2 is available at http://geomag.org/models/EMAG2 and for permanent archive at http://earthref.org/ cgi-bin/er.cgi?s=erda.cgi?n=970. ?? 2009 by the American Geophysical Union.

  17. Reactive oxygen and nitrogen species disturb Ca(2+) oscillations in insulin-secreting MIN6 β-cells.

    Antonucci, Salvatore; Tagliavini, Alessia; Pedersen, Morten Gram

    2015-01-01

    Disturbances in pulsatile insulin secretion and Ca(2+) oscillations in pancreatic β-cells are early markers of diabetes, but the underlying mechanisms are still incompletely understood. Reactive oxygen/nitrogen species (ROS/RNS) are implicated in reduced β-cell function, and ROS/RNS target several Ca(2+) pumps and channels. Thus, we hypothesized that ROS/RNS could disturb Ca(2+) oscillations and downstream insulin pulsatility. We show that ROS/RNS production by photoactivation of aluminum phthalocyanine chloride (AlClPc) abolish or accelerate Ca(2+) oscillations in the MIN6 β-cell line, depending on the amount of ROS/RNS. Application of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitor thapsigargin modifies the Ca(2+) response to high concentrations of ROS/RNS. Further, thapsigargin produces effects that resemble those elicited by moderate ROS/RNS production. These results indicate that ROS/RNS interfere with endoplasmic reticulum Ca(2+) handling. This idea is supported by theoretical studies using a mathematical model of Ca(2+) handling adapted to MIN6 cells. Our results suggest a putative link between ROS/RNS and disturbed pulsatile insulin secretion. PMID:26732126

  18. L'analyse in-situ par fluorescence X : une méthode adaptée à l'estimation de minéralisations en place : application aux minéralisations zincifères

    Eteradossi, Olivier

    1985-01-01

    La possibilité d'utiliser un spectromètre XRF portable pour décrire et estimer une minéralisation avant abattage est étudiée en laboratoire puis sur des ces pratiques de prospection et d'exploitation. La détermination de le géométrie et l'estimation de la teneur d'un volume en place sont des processus indispensables à la bonne marche d'une exploitation minière. Ces informatlons, qui permettent de mieux gérer l'exploitation, soIt en engageant peu de frais de productIon pour des volumes non ren...

  19. Reduction of intestinal polyp formation in min mice fed a high-fat diet with aloe vera gel extract.

    Chihara, Takeshi; Shimpo, Kan; Beppu, Hidehiko; Tomatsu, Akiko; Kaneko, Takaaki; Tanaka, Miyuki; Yamada, Muneo; Abe, Fumiaki; Sonoda, Shigeru

    2013-01-01

    Aloe vera gel supercritical CO2 extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat accumulation, and influence the metabolism of glucose and lipids in animal model experiments. Recent epidemiologic studies have shown that obesity is an established risk factor for several cancers including colorectal cancer. Therefore, we examined the effects of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet. Male Min mice were divided into normal diet (ND), high fat diet (HFD), low dose AVGE (HFD+LAVGE) and high dose AVGE (HFD+HAVGE) groups. The ND group received AIN-93G diet and the latter 3 groups were given modified high-fat AIN-93G diet (HFD) for 7 weeks. AVGE was suspended in 0.5% carboxymethyl cellulose (CMC) and administered orally to mice in HFD+LAVGE and HFD+HAVGE groups every day (except on Sunday) for 7 weeks at a dose of 3.75 and 12.5 mg/kg body weight, respectively. ND and HFD groups received 0.5% CMC alone. Between weeks 4 and 7, body weights in the HFD and HFD+LAVGE groups were reduced more than those in the ND group. However, body weights were not reduced in the HFD+HAVGE group. Mice were sacrificed at the end of the experiment and their intestines were scored for polyps. No significant differences were observed in either the incidence and multiplicity of intestinal polyps (≥0.5 mm in a diameter) among the three groups fed HFD. However, when intestinal polyps were categorized by their size into 0.5-1.4, 1.5-2.4, or ≥2.5 mm, the incidence and multiplicity of large polyps (≥2.5 mm) in the intestine in the HFD+HAVGE group were significantly lower than those in the HFD group. We measured plasma lipid (triglycerides and total cholesterol) and adipocytokine [interleukin-6 and high molecular weight (HMW) adiponectin] levels as possible indicators of mechanisms of inhibition. The results showed that HMW adiponectin levels in the HFD group were significantly lower than those in the ND group. However, the

  20. Approche métallogénique du "Greenstone Belt" de Bogoin (RCA). Sa minéralisation en or

    Biandja, Jean

    1988-01-01

    La minéralisation aurifère primaire du secteur de Bogoin se présente sous forme d'un stockwerk quartzeux de direction N-S encaissé dans des roches vertes. Ces dernières appartiennent à une série métamorphique (limite faciès schistes verts-amphibolite) plissée en un synclinorium de direction N-S qui dessine un "doigt de gant" dans un vaste massif granito-gneissique. La foliation principale (SP) est plan axial de cette structure. L'ensemble est réputé archéen. Le synclinal s'ennoie vers le Sud ...

  1. On the origin of the conductance asymmetry in CeMIn5 (M=Co, Rh, Ir)

    Asymmetric differential conductance has been frequently observed in heavy fermion point-contact junctions. We report such data obtained from the Ce-based 1-1-5 compounds CeMIn5 (M=Co, Rh, Ir). Apart from characteristics due to superconductivity or antiferromagnetism, a striking common feature is an asymmetry in the background conductance, which shows nontrivial temperature and voltage dependencies. These behaviors cannot be explained by the local heating model combined with large Seebeck effect in heavy fermions. We propose that a Fano-like interference may cause the asymmetry. The interference can occur between two conductance channels, one into the conduction band and the other into the heavy electron band formed by the hybridization of conduction electrons with localized f-electrons.

  2. Behçet's pulmonary artery aneurysms treated with infliximab and monitored with the 6-min walk test.

    Kotecha, Jalpa; Kamath, Ajay V; Mukhtyar, Chetan

    2016-04-01

    Pulmonary involvement in Behçet's disease (BD) is uncommon; however, it is potentially fatal due to the risk of massive haemoptysis. We describe the case of a 36-year-old male presenting with a 2-month history of worsening dyspnoea, weight loss, haemoptysis, oral ulceration, erythema nodosum and superficial thrombophlebitis. He was diagnosed with pulmonary vasculitis secondary to BD; however, his symptoms were refractory to initial treatment with cyclophosphamide, azathioprine and prednisolone. We therefore trialled infliximab alongside methotrexate, which led to a remarkable improvement in his condition, enabling eventual discontinuation of prednisolone. Whilst not being one of the treatments currently recommended for managing pulmonary involvement in BD, infliximab has previously been successfully used in cases refractory to conventional therapy. We used the 6-min walk test (distance covered and lowest oxygen saturations) to monitor his progress, which correlated with his symptoms. This may represent a useful adjunct in monitoring the activity of pulmonary vasculitis. PMID:27123312

  3. Fine structure of strength function for β+/EC decay of 160gHo (25.6 min)

    A strength function for the β+/EC decay of the deformed 160gHo (25.6 min) nucleus has been obtained from the experimental data. The fine structure of the strength function Sβ(E) is analyzed. It is found to have a pronounced resonant structure for Gamow-Teller transitions. In Sβ(E) with μτ=+1 the Gamow-Teller resonance is observed to split into two components. This splitting is associated with anisotropy of isovector density oscillation in deformed nuclei. The β+/EC strength function for first-forbidden transitions is obtained in the Coulomb (ξ) approximation. It is shown that Sβ(E) for first-forbidden transitions does not have a pronounced resonant structure

  4. Professor QIN Min's Acupuncture Holistic Therapies System%秦敏针灸整体疗法体系初探

    曾科学; 李敏; 文希; 姚国新; 孙维正; 史琳琳

    2013-01-01

    整体观念是中医理论体系的主要特点之一,针灸疗法的核心也是整体观念.秦敏教授系全国第四批名老中医学术经验继承人,在临床实践中总结出针灸整体疗法,文章从理、法、方、术等四个方面对秦敏教授针灸整体疗法理论体系进行了初探和总结.在整体观念的指导下,确定安神醒脑头皮针、调气扶阳腹针、太阳夹督围刺法三大特色针灸方法,以秦氏飞针术调和阴阳,贯通任督,整体调节,达到治疗的目的.%The holism is one of the main characteristics of the theoretical system of traditional Chinese medicine,the core concept of acupuncture therapy is holism.Professor QIN Min is the fourth batch of national academic experience of famous Chinese medicine heir,in clinical practice of acupuncture therapy and has summed up the acupuncture holism.This article is to discuss and summary acupuncture holistic theory of Professor QIN Min from four aspects including theory,rule,method,technology.In the overall concept,three characteristics acupuncture,that is Anshenxingnao scalp needle,Tiaoqifuyang abdominal acupuncture,Taiyangjiadu surrounded needling method,are determined.Qinshifeizhenshu can be used to balance Yin and Yang,through Ren and Du meridians,regulating the whole condition,and achieving the purpose of treatment.

  5. Gd-EOB-DTPA-enhanced 3.0 T MR imaging: quantitative and qualitative comparison of hepatocyte-phase images obtained 10 min and 20 min after injection for the detection of liver metastases from colorectal carcinoma

    To compare quantitatively and qualitatively hepatocyte-phase images obtained 10 and 20 min (Images-10, and Images-20) after injection of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) to detect liver metastases from colorectal carcinoma on 3.0 T MR imaging. A total of 48 patients (26 men, 22 women; mean age, 64 years) with 88 histopathologically confirmed liver metastases underwent Gd-EOB-DTPA-enhanced MR imaging. Tumour-to-liver contrast-to-noise ratio (CNR), signal intensity gain (SIG) of liver parenchyma and overall image quality were analysed. Two radiologists independently reviewed two sets of MR images: set 1, unenhanced (T1- and T2-weighted), dynamic images and Images-10; set 2, unenhanced, dynamic and Images-20. Sensitivity and positive predictive value (PPV) to detect liver metastases, and diagnostic performance using the alternative free-response receiver operating characteristics (AFROC) method were calculated. The mean tumour-to-liver CNR, SIG of liver parenchyma and overall image quality on Images-20 were significantly higher than those on Images-10. The overall image quality of ''fair to excellent'' was achieved on both images in 93.8% of the patients. Sensitivity, PPV and area under the AFROC curve on set 1 were similar to set 2, including lesions <1 cm. In detecting liver metastases from colorectal carcinoma, Images-10 could replace Images-20 in 3.0 T MR imaging. (orig.)

  6. MicroSISAK. Continuous liquid-liquid extractions of radionuclides at ≥ 0.2 mL/min

    Continuous liquid-liquid extraction of short-lived radionuclides has traditionally been performed with the SISAK system consisting of static mixers and H-centrifuges for phase separation. SISAK operates at flow rates of typically 1 mL/s. Thus, it produces large volumes of radioactive liquid waste that is difficult to dispose of. Therefore, it has been aimed to develop and use a further miniaturised extraction unit based on microtechnology and precision engineering to reduce the flow rate by at least two orders of magnitude. The accordingly developed MicroSISAK device is a micro membrane extractor in which a micromixer element with 2 x 16 feed channels of 30 μm width followed by a 60 μm high mixing chamber is used for intimately contacting the aqueous and organic phase. Subsequent phase separation is achieved via hydrophobic Teflon membranes with a pore size of 1 μm. The MicroSISAK device has been tested and optimized with radiotracers of the group-4 elements Zr and Hf in the system H2SO4/trioctyl amine (TOA) in toluene. At a temperature of 58 C and a flow rate of 0.2 mL/min of both phases, extraction yields of 87 ± 3% were achieved. The transport time from the micromixer to the first Teflon membrane was in this case 3.9s. It can be shortened to 1.56s at a flow rate of 0.5 mL/min. Under similar conditions, the extraction yield of 99mTc milked from a 99Mo generator in the system HNO3/tetraphenyl arsonium chloride (TPAC) in chloroform was 83 ± 3%. In an on-line experiment at the TRIGA Mainz reactor, short-lived Tc isotopes produced in the fission of 235U with thermal neutrons were transported by a He/KCl gas-jet to the chemistry apparatus, deposited by impaction, dissolved in 0.01 mol/L HNO3/KBrO3, and extracted into 10-4 mol/L TPAC in chloroform in MicroSISAK. The separated phases were transported via capillaries to two separate flow-through cells positioned in front of two Ge detectors. The extraction yield determined as the ratio of the Tc γ-ray activities in

  7. IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

    White James P

    2012-07-01

    Full Text Available Abstract Background Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes regulating muscle wasting. Skeletal muscle oxidative capacity and the expression of proteins regulating mitochondrial biogenesis and dynamics are disrupted in severely cachectic ApcMin/+ mice. It has not been determined if these changes occur at the onset of cachexia and are necessary for the progression of muscle wasting. Exercise and anti-cytokine therapies have proven effective in preventing cachexia development in tumor bearing mice, while their effect on mitochondrial content, biogenesis and dynamics is not well understood. The purposes of this study were to 1 determine IL-6 regulation on mitochondrial remodeling/dysfunction during the progression of cancer cachexia and 2 to determine if exercise training can attenuate mitochondrial dysfunction and the induction of proteolytic pathways during IL-6 induced cancer cachexia. Methods ApcMin/+ mice were examined during the progression of cachexia, after systemic interleukin (IL-6r antibody treatment, or after IL-6 over-expression with or without exercise. Direct effects of IL-6 on mitochondrial remodeling were examined in cultured C2C12 myoblasts. Results Mitochondrial content was not reduced during the initial development of cachexia, while muscle PGC-1α and fusion (Mfn1, Mfn2 protein expression was repressed. With progressive weight loss mitochondrial content decreased, PGC-1α and fusion proteins were further suppressed, and fission protein (FIS1 was induced. IL-6 receptor antibody administration after the onset of cachexia improved mitochondrial content, PGC-1α, Mfn1/Mfn2 and FIS1 protein expression. IL-6 over-expression in pre-cachectic mice accelerated body weight loss and muscle wasting, without reducing mitochondrial content, while PGC-1α and Mfn1/Mfn2 protein expression was suppressed and FIS1 protein expression

  8. Individual variability in cardiac biomarker release after 30 min of high-intensity rowing in elite and amateur athletes.

    Legaz-Arrese, Alejandro; López-Laval, Isaac; George, Keith; Puente-Lanzarote, Juan José; Moliner-Urdiales, Diego; Ayala-Tajuelo, Vicente Javier; Mayolas-Pi, Carmen; Reverter-Masià, Joaquín

    2015-09-01

    This study had two objectives: (i) to examine individual variation in the pattern of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) release in response to high-intensity rowing exercise, and (ii) to establish whether individual heterogeneity in biomarker appearance was influenced by athletic status (elite vs. amateur). We examined cTnI and NT-proBNP in 18 elite and 14 amateur rowers before and 5 min, 1, 3, 6, 12, and 24 h after a 30-min maximal rowing test. Compared with pre-exercise levels, peak postexercise cTnI (pre: 0.014 ± 0.030 μg·L(-1); peak post: 0.058 ± 0.091 μg·L(-1); p = 0.000) and NT-proBNP (pre: 15 ± 11 ng·L(-1); peak post: 31 ± 19 ng·L(-1); p = 0.000) were elevated. Substantial individual heterogeneity in peak and time-course data was noted for cTnI. Peak cTnI exceeded the upper reference limit (URL) in 9 elite and 3 amateur rowers. No rower exceeded the URL for NT-proBNP. Elite rowers had higher baseline (0.019 ± 0.038 vs. 0.008 ± 0.015 μg·L(-1); p = 0.003) and peak postexercise cTnI (0.080 ± 0.115 vs. 0.030 ± 0.029 μg·L(-1); p = 0.022) than amateur rowers, but the change with exercise was similar between groups. There were no significant differences in baseline and peak postexercise NT-proBNP between groups. In summary, marked individuality in the cTnI response to a short but high-intensity rowing bout was observed. Athletic status did not seem to affect the change in cardiac biomarkers in response to high-intensity exercise. PMID:26307519

  9. Lichens as possible agents of sandstone deterioration in Jesuitic ruins of San Ignacio Miní (Misiones Province, Argentina

    Rosato, V. G.

    2010-09-01

    Full Text Available The ruins of San Ignacio Miní, in NE Argentina, Misiones Province, included by the UNESCO in the list of World Heritage in 1984, were built in the 18th century by the Guarani people under the supervision of the Jesuite Congregation. The ruins are located in a tropical weather zone, exposed to extreme conditions of heat and humidity affecting the rocks used in its construction. These rocks are identified as siliceous sandstones, mainly formed by rounded to subrounded clasts, with scarce angulose particles, containing 96% quartz. Weather characteristics encourage the growth of vascular plants as well as algae and mosses and other organisms that damage materials. Among these, there are 18 lichen species (belonging to 18 genera, 8 foliose, 3 fruticose and 7 crustose. The damaging action of these lichens has been observed through SEM observations and EDAX microanalysis of rock samples colonized by Caloplaca sp. and Buellia sp.

    Incluidas en la lista de Patrimonio Mundial por la UNESCO, las ruinas de San Ignacio Miní, en el NE de Argentina, provincia de Misiones, fueron construidas en el siglo XVIII por pobladores guaraníes supervisados por la Compañía de Jesús. Las ruinas se encuentran en una zona de clima tropical, expuestas a condiciones extremas de calor y humedad que alteran a las rocas empleadas en su construcción. Estas rocas se identifican como areniscas silíceas, formadas por clastos redondeados a sub-redondeados, con escasas partículas angulosas, con un contenido de 96,0% cuarzo. Las características del clima favorecen el desarrollo tanto de plantas vasculares como también de musgos, algas y otros organismos capaces de dañar a los materiales. Entre éstos se incluyen 18 especies de líquenes (pertenecientes a 18 géneros, 8 foliosos, 3 fruticosos y 7 crustosos. Las observaciones con SEM y los microanálisis EDE de muestras de roca colonizadas por Caloplaca sp. y Buellia sp sugieren que estos líquenes ejercen una acci

  10. Random Secure Comparator Selection Based Privacy-Preserving MAX/MIN Query Processing in Two-Tiered Sensor Networks

    Hua Dai

    2016-01-01

    Full Text Available Privacy-preserving data queries for wireless sensor networks (WSNs have drawn much attention recently. This paper proposes a privacy-preserving MAX/MIN query processing approach based on random secure comparator selection in two-tiered sensor network, which is denoted by RSCS-PMQ. The secret comparison model is built on the basis of the secure comparator which is defined by 0-1 encoding and HMAC. And the minimal set of highest secure comparators generating algorithm MaxRSC is proposed, which is the key to realize RSCS-PMQ. In the data collection procedures, the sensor node randomly selects a generated secure comparator of the maximum data into ciphertext which is submitted to the nearby master node. In the query processing procedures, the master node utilizes the MaxRSC algorithm to determine the corresponding minimal set of candidate ciphertexts containing the query results and returns it to the base station. And the base station obtains the plaintext query result through decryption. The theoretical analysis and experimental result indicate that RSCS-PMQ can preserve the privacy of sensor data and query result from master nodes even if they are compromised, and it has a better performance on the network communication cost than the existing approaches.

  11. A Count Model to Study the Correlates of 60 Min of Daily Physical Activity in Portuguese Children

    Alessandra Borges

    2015-02-01

    Full Text Available This study aimed to present data on Portuguese children (aged 9–11 years complying with moderate-to-vigorous physical activity (MVPA guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane–Armitage chi-square test indicated a linear and negative trend (p < 0.001 from none to all seven days of children complying with the guidelines. The count model explained 22% of the variance in meeting MVPA guidelines daily. Being a girl, having a higher BMI, belonging to families with higher income, sleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates’ roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children.

  12. A count model to study the correlates of 60 min of daily physical activity in Portuguese children.

    Borges, Alessandra; Gomes, Thayse Natacha; Santos, Daniel; Pereira, Sara; dos Santos, Fernanda K; Chaves, Raquel; Katzmarzyk, Peter T; Maia, José

    2015-03-01

    This study aimed to present data on Portuguese children (aged 9-11 years) complying with moderate-to-vigorous physical activity (MVPA) guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA) was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane-Armitage chi-square test indicated a linear and negative trend (psleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates' roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children. PMID:25730296

  13. Integrated water vapor from IGS ground-based GPS observations. Initial results from a global 5-min data set

    Heise, S.; Dick, G.; Gendt, G.; Schmidt, T.; Wickert, J. [GFZ German Research Centre for Geosciences, Potsdam (Germany). Dept. 1 Geodesy and Remote Sensing

    2009-07-01

    Ground based GPS zenith path delay (ZPD) measurements are well established as a powerful tool for integrated water vapor (IWV) observation. The International GNSS Service (IGS) provides ZPD data of currently more than 300 globally distributed GPS stations. To derive IWV from these data, meteorological information (ground pressure and mean temperature above the station) are needed. Only a limited number of IGS stations is equipped with meteorological ground sensors up to now. Thus, meteorological data for IWV conversion are usually derived from nearby ground meteorological observations (ground pressure) and meteorological analyses (mean temperature). In this paper we demonstrate for the first time the applicability of ground pressure data from ECMWF meteorological analysis fields in this context. Beside simplified data handling (no single station data and quality control) this approach allows for IWV derivation if nearby meteorological stations are not available. Using ECMWF ground pressure and mean temperature data the new IGS 5-min ZPD data set has been converted to IWV for the first time. We present initial results from selected stations with ground meteorological sensors including pressure and temperature comparisons between ECMWF and local measurements. The GPS IWV is generally validated by comparison with ECMWF IWV. The ECMWF derived station meteorological data are compared with local measurements at all accordingly equipped stations. Based on this comparison, the mean error (in terms of standard deviation) introduced by time interpolation of the 6-hourly ECMWF data is estimated below 0.2 mm IWV. (orig.)

  14. Recent fully non-inductive operation results in Tore Supra with 6 min, 1 GJ plasma discharges

    The experimental programme of Tore Supra, the largest superconducting tokamak in the world (a = 0.72 m, R = 2.4 m, Ip T < 4.5 T) was devoted in 2003 to studying the heat removal capability and particle exhaust in steady-state fully non-inductive current drive discharges simultaneously. This required both advanced technology integration and steady-state real-time plasma control. In particular, an improvement of the plasma position to within a range of few millimetres, and new real-time controls of radio frequency power and various actuators built around a shared memory network, have allowed Tore Supra to access a powerful steady-state regime with an improved safety level for the actively cooled plasma facing components. Feedback controlled fully non-inductive plasma discharges have been sustained in a steady-state regime for up to 6 min with a new world record for injected-extracted energy exceeding 1 GJ. Experimental results and an analysis of the physics involved in these discharges are reported and discussed. (author)

  15. Real time control of fully non-inductive operation in Tore Supra leading to 6 min, 1 GJ plasma discharges

    The experimental programme of Tore Supra (a = 0.72 m, R = 2.4 m, I p T < 4.5 T) has been devoted in 2003 to study simultaneously heat removal capability and particle exhaust in steady-state fully non-inductive current drive discharges. This required both advanced technology integration and steady-state real time plasma control. In particular, an improvement of the plasma position within a few millimetres range, and new real time cross controls between radio frequency (RF) power and various actuators built around a shared memory network, have allowed Tore Supra to access a powerful steady-state regime with an improved safety level for the actively cooled plasma facing components. Feedback controlled fully non-inductive plasma discharges have been sustained in a steady-state regime up to 6 min with a new world record of injected-extracted energy exceeding 1 GJ. Advanced tools, experimental results and brief physics analysis of these discharges are presented and discussed

  16. An Adaptive Fuzzy Min-Max Neural Network Classifier Based on Principle Component Analysis and Adaptive Genetic Algorithm

    Jinhai Liu

    2012-01-01

    Full Text Available A novel adaptive fuzzy min-max neural network classifier called AFMN is proposed in this paper. Combined with principle component analysis and adaptive genetic algorithm, this integrated system can serve as a supervised and real-time classification technique. Considering the loophole in the expansion-contraction process of FMNN and GFMN and the overcomplex network architecture of FMCN, AFMN maintains the simple architecture of FMNN for fast learning and testing while rewriting the membership function, the expansion and contraction rules for hyperbox generation to solve the confusion problems in the hyperbox overlap region. Meanwhile, principle component analysis is adopted to finish dataset dimensionality reduction for increasing learning efficiency. After training, the confidence coefficient of each hyperbox is calculated based on the distribution of samples. During classifying procedure, utilizing adaptive genetic algorithm to complete parameter optimization for AFMN can also fasten the entire procedure than traversal method. For conditions where training samples are insufficient, data core weight updating is indispensible to enhance the robustness of classifier and the modified membership function can adjust itself according to the input varieties. The paper demonstrates the performance of AFMN through substantial examples in terms of classification accuracy and operating speed by comparing it with FMNN, GFMN, and FMCN.

  17. Early static {sup 18}F-FET-PET scans have a higher accuracy for glioma grading than the standard 20-40 min scans

    Albert, Nathalie L.; Winkelmann, Isabel; Wenter, Vera; Mille, Erik; Todica, Andrei; Brendel, Matthias; Bartenstein, Peter [Ludwig-Maximilians-University Munich, Department of Nuclear Medicine, Munich (Germany); Suchorska, Bogdana; Tonn, Joerg-Christian [Ludwig-Maximilians-University Munich, Department of Neurosurgery, Munich (Germany); Schmid-Tannwald, Christine [Ludwig-Maximilians-University Munich, Institute for Clinical Radiology, Munich (Germany); La Fougere, Christian [University of Tuebingen, Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Tuebingen (Germany)

    2016-06-15

    Current guidelines for glioma imaging by positron emission tomography (PET) using the amino acid analogue O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine ({sup 18}F-FET) recommend image acquisition from 20-40 min post injection (p.i.). The maximal tumour-to-background evaluation (TBR{sub max}) obtained in these summation images does not enable reliable differentiation between low and high grade glioma (LGG and HGG), which, however, can be achieved by dynamic {sup 18}F-FET-PET. We investigated the accuracy of tumour grading using TBR{sub max} values at different earlier time points after tracer injection. Three hundred and fourteen patients with histologically proven primary diagnosis of glioma (131 LGG, 183 HGG) who had undergone 40-min dynamic {sup 18}F-FET-PET scans were retrospectively evaluated. TBR{sub max} was assessed in the standard 20-40 min summation images, as well as in summation images from 0-10 min, 5-15 min, 5-20 min, and 15-30 min p.i., and kinetic analysis was performed. TBR{sub max} values and kinetic analysis were correlated with histological classification. ROC analyses were performed for each time frame and sensitivity, specificity, and accuracy were assessed. TBR{sub max} values in the earlier summation images were significantly better for tumour grading (P < 0.001) when compared to standard 20-40 min scans, with best results for the early 5-15 min scan. This was due to higher TBR{sub max} in the HGG (3.9 vs. 3.3; p < 0.001), while TBR{sub max} remained nearly stable in the LGG (2.2 vs. 2.1). Overall, accuracy increased from 70 % in the 20-40 min analysis to 77 % in the 5-15 min images, but did not reach the accuracy of dynamic analysis (80 %). Early TBR{sub max} assessment (5-15 min p.i.) is more accurate for the differentiation between LGG and HGG than the standard static scan (20-40 min p.i.) mainly caused by the characteristic high {sup 18}F-FET uptake of HGG in the initial phase. Therefore, when dynamic {sup 18}F-FET-PET cannot be performed

  18. MicroSISAK. Continuous liquid-liquid extractions of radionuclides at {>=} 0.2 mL/min

    Hild, D.; Eberhardt, K.; Kratz, J.V.; Wiehl, N. [Mainz Univ. (Germany). Inst. fuer Kernchemie; Even, J. [Mainz Univ. (Germany). Inst. fuer Kernchemie; Helmholtz-Institut Mainz, Mainz (Germany); Loeb, P.; Werner, B.; Hofmann, C. [Institut fuer Mikrotechnik Mainz GmbH, Mainz (Germany)

    2013-07-01

    Continuous liquid-liquid extraction of short-lived radionuclides has traditionally been performed with the SISAK system consisting of static mixers and H-centrifuges for phase separation. SISAK operates at flow rates of typically 1 mL/s. Thus, it produces large volumes of radioactive liquid waste that is difficult to dispose of. Therefore, it has been aimed to develop and use a further miniaturised extraction unit based on microtechnology and precision engineering to reduce the flow rate by at least two orders of magnitude. The accordingly developed MicroSISAK device is a micro membrane extractor in which a micromixer element with 2 x 16 feed channels of 30 {mu}m width followed by a 60 {mu}m high mixing chamber is used for intimately contacting the aqueous and organic phase. Subsequent phase separation is achieved via hydrophobic Teflon membranes with a pore size of 1 {mu}m. The MicroSISAK device has been tested and optimized with radiotracers of the group-4 elements Zr and Hf in the system H{sub 2}SO{sub 4}/trioctyl amine (TOA) in toluene. At a temperature of 58 C and a flow rate of 0.2 mL/min of both phases, extraction yields of 87 {+-} 3% were achieved. The transport time from the micromixer to the first Teflon membrane was in this case 3.9s. It can be shortened to 1.56s at a flow rate of 0.5 mL/min. Under similar conditions, the extraction yield of {sup 99m}Tc milked from a {sup 99}Mo generator in the system HNO{sub 3}/tetraphenyl arsonium chloride (TPAC) in chloroform was 83 {+-} 3%. In an on-line experiment at the TRIGA Mainz reactor, short-lived Tc isotopes produced in the fission of {sup 235}U with thermal neutrons were transported by a He/KCl gas-jet to the chemistry apparatus, deposited by impaction, dissolved in 0.01 mol/L HNO{sub 3}/KBrO{sub 3}, and extracted into 10{sup -4} mol/L TPAC in chloroform in MicroSISAK. The separated phases were transported via capillaries to two separate flow-through cells positioned in front of two Ge detectors. The

  19. Study of the excited states of 187Pt in the decay of 187Au (8.4 min)

    The decay of 187Au to 187Pt has been studied with mass-separated sources from the UNISOR facility. Multiscaled spectra of γ-rays, x-rays, and conversion electrons were obtained along with γ-γ-t, γ-x-t, e--γ-t, and e--x-t coincidence data. The half life of 187Au was measured to be 8.4 +- 0.3 min. A decay scheme consisting of 56 excited states and 245 transitions that incorporates 88% of the decay intensity assigned to 187Au has been constructed. The i/sub 13/2/ band in 187Pt is populated through low-spin band members in approximately 4% of the decays of 187Au. Levels at 260, 288, and 507 keV are found to de-excite by EO transitions. The ground-state decay energy is deduced to be Q/sub EC/ = 3.90 +- 0.15 MeV from a γ-gated β+/EC ratio. The positive parity states in 187Pt are compared with calculations made with the Lund Model [Larsson et. al., 1978]. Also an anion exchange and distillation procedure is described for preparing reactor-produced carrier-free 18F as K18F complexed with 18-crown-6 in acetonitrile for subsequent synthesis of labelled organic compounds. The reaction sequence 6Li(n,t) 4He - 16O(t,n) 18F produced yields of approximately 250 mCi of 18F per hour per gram of 96% enriched 6Li, as 6LiOH x H2O target, in a reactor thermal-neutron flux of 3 x 1013 n cm-2sec-1. Yields of tritium-free carrier-free 18F dissolved in the crown ether solution typically reach 85 +- 5% within the 45 minutes required for the radiochemical procedure

  20. [Diurnal variations of greenhouse gas fluxes at the water-air interface of aquaculture ponds in the Min River estuary].

    Yang, Ping; Tong, Chuan; He, Qing-Hua; Huang, Jia-Fang

    2012-12-01

    Wetland reclamation and aquaculture is one of the main disturbance types in coastal wetlands. Diurnal variations of CO2, CH4 and N2O fluxes at the water-air interface were determined using a floating chambers + gas chromatography method in a shrimp pond, and a mixed culture pond of fish and shrimp in October in the Shanyutan Wetland of the Min River estuary, southeast China. Meanwhile, the meteorological indicators in ground surface and physical, chemical and biological indicators of surface water were also measured. CO2, CH4 and N2O fluxes at the water-air interface all demonstrated distinct diurnal variations. Both shrimp pond and mixed culture pond of fish and shrimp functioned as a sink of CO2 [the diurnal averaged CO2 fluxes were -48.79 and -105.25 mg x (m2 x h)(-1), respectively], and a source of CH4 [the diurnal averaged CH4 fluxes were 1.00 and 5.74 mg x (m2 x h)(-1), respectively]; the diurnal averaged CO2 and CH4 fluxes at the water-air interface of the mixed culture of fish and shrimp pond were higher than that of the shrimp pond. Greenhouse gas fluxes at the water-air interface from the aquaculture ponds were influenced by many factors. Multiple stepwise regression analysis showed that the concentration of Chlorophyll was the major factor affecting the CO2 fluxes, and the concentrations of SO4(2-) and PO4(3-) were the major factors affecting the CH4 fluxes at the water-air interface of the shrimp pond; whereas water temperature and Chlorophyll were the major factors affecting the CO2 fluxes, and dissolved oxygen, PO4(3-) and pH were the major factors affecting the CH4 fluxes at the water-air interface of the mixed culture pond of fish and shrimp. PMID:23379142

  1. CH4MIN technology: a sustainable solution for the destruction of dilute methane emissions and the production of useful energy

    Large quantities of methane are released into the atmosphere by underground coal mines. The coal industry worldwide is responsible for the emission of the equivalent of 460 million tons per year of carbon dioxide. Of that amount, approximately 250 million tons per year originate from coal mine ventilation air. A novel technology providing a sustainable energy solution to the conversion of these emissions into useful energy has been developed by the Canada Energy Technology Centre in Varennes, part of Natural Resources Canada. The technology has been called CH4MIN and is capable of converting the dilute methane contained in the emissions and produces useful energy in the form of heat or electricity. The technology couples the catalytic oxidation of the lean emissions in the reactor with regenerative heat exchange. Two beds of inert material are separated by the catalytic bed, and it acts as the regenerative heat exchanger, providing a very efficient heat transfer. Thermal stability and stable reactor operation are ensured by a periodic reversal in the direction of the flow of the mine ventilation air. Some of the heat from the reactor is used to produce electricity or heat for the mine. The preparation of a mathematical simulation of the expected process and an independent techno-economic feasibility study were performed during phase I of the development. New chemical reactor concepts, complex heat and mass transfer simulations were developed during phase II, as well as the development of a new two-dimensional model and algorithms, a novel design of a flow reversal reactor, the construction of unique large scale 500 millimeter diameter pilot scale reactor, the selection and testing of a catalyst with low pressure drop, high temperature resistance, poison resistance, and low cost. The preparation of the first industrial demonstration is being carried out as part of phase III. This phase includes the licensing of the technology to private industry along with obtaining

  2. Modeling of the dynamic pole-to-pole oscillations of the min proteins in bacterial cell division: The effect of an external field

    Modchang, C; Triampo, W; Ngamsaad, W; Nuttawut, N; Tang, I M; Lenbury, Y; Modchang, Charin; Kanthang, Paisan; Triampo, Wannapong; Ngamsaad, Waipot; Nuttawut, Narin; Lenbury, Yongwimol

    2004-01-01

    One of the most important steps in the developmental process of the bacteria cell at the cellular level is the determination of the middle of the cell and the proper placement of the septum, these being essential to the division of the cell. In E. coli, this step depends on the proteins MinC, MinD, and MinE. Exposure to a constant electric field may cause the bacteria cell division mechanism to change, resulting in an abnormal cytokinesis. To see the effects of an external field e.g., an electric or magnetic field on this process, we have solved a set of deterministic reaction diffusion equations, which incorporate the influence of an electric field. We have found some changes in the dynamics of the oscillations of the min proteins from pole to pole. The numerical results show some interesting effects, which are qualitatively in good agreement with some experimental results.

  3. AREVA announces US$ 7.75 Per share friendly cash offer for UraMin; Offre publique d'achat amicale d'AREVA sur UraMin sur la base d'un prix de 7,75US$ par action

    NONE

    2007-07-01

    AREVA and UraMin Inc. ('UraMin') entered on June 15, 2007 into an agreement in respect of AREVA's friendly cash offer for 100% of the share capital of UraMin. UraMin is listed in London (AIM) and Toronto (TSX). AREVA (Euronext Paris) already owns 5.5% of UraMin's share capital. This cash offer of AREVA will be made through its indirect wholly-owned subsidiary CFMM Development ('AREVA') based on a price of US$ 7.75 per UraMin share. The total offer consideration amounts to more than USD 2.5 billion for 100% of the fully diluted share capital of UraMin. This represents a premium of 21% over UraMin 20-day weighted average trading price ending on June 8, 2007. The UraMin Board of Directors, after consulting with its financial advisors, has determined that the offer is fair and in the best interest of the UraMin shareholders and it has resolved to recommend acceptance of the Offer. BMO Capital Markets has provided an opinion that the offer is fair, from a financial point of view, to the UraMin shareholders. In connection with the offer, all directors and certain other shareholders representing approximately 25% of the outstanding UraMin shares (calculated on a fully diluted basis) have entered into lock-up agreements with AREVA pursuant to which they have agreed to tender all their UraMin shares to AREVA's offer. The support agreement entered into between AREVA and UraMin provides for, among other things, in case a superior proposal is accepted by UraMin, a right to match in favour of AREVA. The support agreement also includes a break up fee in favour of AREVA of US$ 75 million under certain circumstances. Concurrently with the closing of the proposed offer, UraMin will declare a dividend payable in shares of the capital of Niger Uranium Limited held by UraMin (where permitted by law) or a cash equivalent of the value of such shares.

  4. The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression

    Baran, Amy A.; Silverman, Karen A.; Zeskand, Joseph; Koratkar, Revati; Palmer, Ashley; McCullen, Kristen; Curran, Walter J.; Edmonston, Tina Bocker; Linda D. Siracusa; Buchberg, Arthur M.

    2007-01-01

    Inactivation of the APC gene is considered the initiating event in human colorectal cancer. Modifier genes that influence the penetrance of mutations in tumor-suppressor genes hold great potential for preventing the development of cancer. The mechanism by which modifier genes alter adenoma incidence can be readily studied in mice that inherit mutations in the Apc gene. We identified a new modifier locus of ApcMin-induced intestinal tumorigenesis called Modifier of Min 2 (Mom2). The polyp-resi...

  5. Yi-Qi-Zeng-Min-Tang,a Chinese medicine,ameliorates insulin resistance in type 2 diabetic rats

    Zeng Zhang; Hong-Li Xue; Yi Liu; Wen-Jian Wang

    2011-01-01

    AIM:To investigate the effects of the Chinese herbal decoction,Yi-Qi-Zeng-Min-Tang (YQZMT),on insulin resistance in type 2 diabetic rats. METHODS:Sprague-Dawley rats were divided into two dietary regiments by feeding either normal pellet diet (NPD) or high fat diet (HFD).Four weeks later,the HFD-fed rats were injected intraperitoneally with lowdose streptozotocin (STZ).Rats with non-fasting blood glucose level ≥ 16.67 mmol/L were considered type 2 diabetic and further divided into five subgroups:the type 2 diabetes model group,low-dose,medium-dose and high-dose YQZMT groups,and rosiglitazone group. Age-matched NPD-fed rats served as controls.YQZMT or rosiglitazone were administered for 8 wk.Intraperitoneal glucose and insulin tolerance tests were performed before and after the treatment to measure the glucose tolerance and insulin sensitivity.Serum levels of biochemical parameters,adipocytokines,such as tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),as well as free fatty acids (FFAs),were also analyzed. RESULTS:There was significant elevation of insulin resistance and serum levels of fasting glucose (12.82 ± 1.08 mmol/L vs 3.60 ± 0.31 mmol/L,P < 0.01),insulin (7197.36 ± 253.89 pg/mL vs 4820.49 ± 326.89 pg/mL, P < 0.01),total cholesterol (TC) (8.40 ± 0.49 mmol/L vs 2.14 ± 0.06 mmol/L,P < 0.01),triglyceride (2.24 ± 0.12 mmol/L vs 0.78 ± 0.05 mmol/L,P < 0.01),low-density lipoprotein cholesterol (LDL-c) (7.84 ± 0.51 mmol/L vs 0.72 ± 0.04 mmol/L,P < 0.01) and decrease in high-density lipoprotein cholesterol (HDL-c) (0.57 ± 0.03 mmol/L vs 1.27 ± 0.03 mmol/L,P < 0.01) in the low-dose STZ and high-fat diet induced type 2 diabetic group when compared with the control group. Administration of YQZMT induced dose- and timedependent changes in insulin resistance,glucose and lipid profile,and reduced levels of FFA,TNF-α and IL-6 in the type 2 diabetic rats.After the treatment, compared with the diabetic group,the insulin resistance was ameliorated in the

  6. Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model

    Friedrich Duenschede; Ines Gockel; Alexandra K Kiemer; Theodor Junginger; Kirsten Erbes; Nina Riegler; Patrick Ewald; Achim Kircher; Stefanie Westermann; Arno Schad; Imke Miesmer; Simon Albrecht-Sch(o)ck

    2007-01-01

    AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by αα-lipoic acid (LA).METHODS: Several groups of rats were compared:sham operated animals, non-pretreated animals (nt),animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion)prior to sustained ichemia, and animals receiving 500μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia.RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19±2 vs 10±1, P<0.05 and 29±5 vs 12±1,P<0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1±0.3 vs 1.8±0.2, P<0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towards anti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death.CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia,possibly by downregulation of pro-apoptotic Bax.

  7. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSats: spectrometer characterization techniques, spectrometer capabilities, and solar science objectives

    Moore, Christopher S; Caspi, Amir; Mason, James P

    2016-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) are twin 3U CubeSats. The first of the twin CubeSats (MinXSS-1) launched in December 2015 to the International Space Station for deployment in mid-2016. Both MinXSS CubeSats utilize a commercial off the shelf (COTS) X-ray spectrometer from Amptek to measure the solar irradiance from 0.5 to 30 keV with a nominal 0.15 keV FWHM spectral resolution at 5.9 keV, and a LASP-developed X-ray broadband photometer with similar spectral sensitivity. MinXSS design and development has involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. The majority of previous solar soft X-ray measurements have been either at high spectral resolution with a narrow bandpass or spectrally integrating (broadband) photometers. MinXSS will conduct unique soft X-ray measurements with moderate spectral resolution over a relatively large energy range to study solar active region evolution, solar flares, and the effects of solar soft ...

  8. A 20 min window is optimal in a non-wear algorithm for tri-axial thigh-worn accelerometry in overweight people

    A valid non-wear algorithm for activity monitors is crucial to avoid the misclassification of sedentary time as non-wear time, and vice versa. Characteristics of the algorithm, such as time windows, should be well defined and tested. Furthermore, using tri-axial data might influence the algorithm’s performance. This study assessed the optimal time window length in a non-wear algorithm for overweight adults, applied to tri-axial data from sixteen participants. Ten time windows, from 10 up to 120 min, were tested with a diary as a criterion measure. We assessed the bias in non-wear time, sensitivity and specificity. The optimal time window length was based on ten participants; the validation of this time window was carried out with six other participants. The time window of 20 min showed the highest and 120 min showed the lowest mean amount of correctly classified non-wear time, at 94% and 70% respectively. Sensitivity and specificity were considered optimal in the 20 min time window. Validation of this time window demonstrated a sensitivity and specificity of 86% and 83% respectively. A 20 min time window showed the best non-wear estimations. The current study utilized tri-axial raw data and 1 s epoch data which might have facilitated the application of a short time window and thereby decreased the risk of misclassifying non-wear. (paper)

  9. Nuclear data for cyclotron production of 114mIn/114In and 140Nd/140Pr used in gamma camera monitoring, RIT, ERT and PET

    Aim of the presented study is to compare the calculated cross sections for the production of 140Nd/140Pr and 114mIn/114In via different reactions with incident particle energy up to 50 MeV as a part of systematic studies on particle-induced activations on metal target, theoretical calculation of production yield, calculation of target thickness requirement and suggestion for optimum reaction to produce Neodymium-140 and Indium-114m. 140Nd/140Pr and 114mIn/114In excitation functions via natCe(3He,xn)140Nd → 140Pr, 141Pr(p,2n)140Nd → 140Pr, 141Pr(d,3n)140Nd → 140Pr, 114Cd(p,n)114mIn → 114In, 114Cd(d,2n)114mIn → 114In and 116Cd(p,3n)114mIn → 114In reactions were calculated by ALICE/91, ALICE/ASH (GDH Model and Hybrid Model) and TALYS-1.2 (Equilibrium and Pre-Equilibrium) codes and compared to existing data. (orig.)

  10. Proteomic screening of glucose-responsive and glucose non-reponsive MIN-6 beta cells reveals differential expression of protein involved in protein folding, secretion and oxidative stress

    Dowling, P.; O´Driscoll, L.; O´Sullivan, F.;

    2006-01-01

    The glucose-sensitive insulin-secretion (GSIS) phenotype is relatively unstable in long-term culture of beta cells. The purpose of this study was to investigate relative changes in the proteome between glucose-responsive (low passage) and glucose non-responsive (high passage) murine MIN-6...... pancreatic beta cells. The 2D-DIGE and subsequent DeCyder analysis detected 3351 protein spots in the pH range of 4-7. Comparing MIN-6(H) to MIN-6(L) and using a threshold of 1.2-fold, the number of proteins with a decrease in expression level was 152 (4.5%), similar was 3140 (93.7%) and increased 59 (1...... protein 29 (ERp29); 78-kDa glucose-related protein, (GRP78); 94-kDa glucose-related protein (GRP94); protein disulphide isomerase; carbonyl reductase 3; peroxidoxin 4 and superoxide dismutase 1. These results suggest that non-GSIS MIN-6 cells do not have the same ability/capacity of glucose-responsive MIN...

  11. Les drogues minérales et chimiques dans la pharmacopée médiévale. Quelques problèmes critiques

    Halleux, Robert

    2015-01-01

    La pharmacopée vétérinaire et la pharmacopée humaine emploient un certain nombre de minéraux. Ce sont largement les mêmes, quoiqu’il y ait dans les dosages et la combinaison des différences à expliquer. Les dernières décennies du défunt siècle ont vu paraître plusieurs ouvrages qui ont renouvelé la problématique du monde minéral au Moyen Âge. Hans Lüschen, Die Νamen der Steine (Thun-München, 1968), a donné le premier dictionnaire historique de minéralogie ; Dietlinde goltz, Studien zur Geschi...

  12. Estratégia de controle de qualidade de minérios na lavra utilizando simulação geoestatística

    Fernando Gambin; João Felipe C. L. Costa; Jair Carlos Koppe

    2005-01-01

    Novas centrais térmicas utilizam carvão ROM (run of mine) na geração de energia termoelétrica. Assim, flutuações de qualidade do carvão serão transferidas da mina para o consumidor final. Contratos entre produtor-consumidor estabelecem limites para parâmetros geológicos e tecnológicos do produto final (minério ROM). O descumprimento dos limites estabelecidos gera penalização e/ou rejeição de lotes de minério. O custo elevado dessas penalizações recomenda o controle de qualidade do minério no ...

  13. Protection of Military Vehicles Against Mine Threats and Improvised Explosive Devices / Ochrona Pojazdów Wojskowych Przed Wybuchem Min i Improwizowanych Urządzeń Wybuchowych

    Niezgoda Tadeusz

    2015-09-01

    Full Text Available Pojazdy wojskowe są narażone na działanie m.in. fali wybuchowej min oraz improwizowanych urządzeń wybuchowych IED (z ang. improvised explosive device. Dotychczasowe rozwiązania konstrukcyjne pancerzy pojazdów wojskowych nie zapewniają ich ochrony na maksymalnym poziomie. W publikacji przedstawiono rozwiązania konstrukcyjne, których celem jest zwiększenie odporności pojazdów wojskowych na eksplozję ładunków wybuchowych. Ponadto scharakteryzowano wymagania dotyczące odporności pojazdów wojskowych na wybuch min i urządzeń IED. Przedstawiono również przykładowe wyniki badań paneli energochłonnych oraz sformułowane na ich podstawie wnioski do dalszego rozwoju konstrukcji ochronnych.

  14. Lack of anti-tumor activity with the β-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis

    Highlights: • Wnt/β-catenin signaling is aberrantly activated in most colorectal cancers. • Locked nucleic acid (LNA)-based antisense is a novel tool for cancer therapy. • β-Catenin inhibition was observed in mature intestinal tissue of LNA-treated mice. • Further investigation of Wnt/β-catenin targeted therapies is warranted. - Abstract: Background: Previously, we showed that short-term inhibition of β-catenin expression and reversal of aberrant β-catenin subcellular localization by the selective COX-2 inhibitor celecoxib is associated with adenoma regression in the C57BL/6J Min/+ mouse. Conversly, long-term administration resulted in tumor resistance, leading us to investigate alternative methods for selective β-catenin chemoprevention. In this study, we hypothesized that disruption of β-catenin expression by EZN-3892, a selective locked nucleic acid (LNA)-based β-catenin inhibitor, would counteract the tumorigenic effect of Apc loss in Min/+ adenomas while preserving normal intestinal function. Materials and methods: C57BL/6J Apc+/+ wild-type (WT) and Min/+ mice were treated with the maximum tolerated dose (MTD) of EZN-3892 (30 mg/kg). Drug effect on tumor numbers, β-catenin protein expression, and nuclear β-catenin localization were determined. Results: Although the tumor phenotype and β-catenin nuclear localization in Min/+ mice did not change following drug administration, we observed a decrease in β-catenin expression levels in the mature intestinal tissue of treated Min/+ and WT mice, providing proof of principle regarding successful delivery of the LNA-based antisense vehicle. Higher doses of EZN-3892 resulted in fatal outcomes in Min/+ mice, likely due to β-catenin ablation in the intestinal tissue and loss of function. Conclusions: Our data support the critical role of Wnt/β-catenin signaling in maintaining intestinal homeostasis and highlight the challenges of effective drug delivery to target disease without permanent toxicity to

  15. Lack of anti-tumor activity with the β-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis

    Hasson, Rian M.; Briggs, Alexandra; Rizvi, Hira; Carothers, Adelaide M.; Davids, Jennifer S.; Bertagnolli, Monica M.; Cho, Nancy L., E-mail: nlcho@partners.org

    2014-02-14

    Highlights: • Wnt/β-catenin signaling is aberrantly activated in most colorectal cancers. • Locked nucleic acid (LNA)-based antisense is a novel tool for cancer therapy. • β-Catenin inhibition was observed in mature intestinal tissue of LNA-treated mice. • Further investigation of Wnt/β-catenin targeted therapies is warranted. - Abstract: Background: Previously, we showed that short-term inhibition of β-catenin expression and reversal of aberrant β-catenin subcellular localization by the selective COX-2 inhibitor celecoxib is associated with adenoma regression in the C57BL/6J Min/+ mouse. Conversly, long-term administration resulted in tumor resistance, leading us to investigate alternative methods for selective β-catenin chemoprevention. In this study, we hypothesized that disruption of β-catenin expression by EZN-3892, a selective locked nucleic acid (LNA)-based β-catenin inhibitor, would counteract the tumorigenic effect of Apc loss in Min/+ adenomas while preserving normal intestinal function. Materials and methods: C57BL/6J Apc{sup +/+} wild-type (WT) and Min/+ mice were treated with the maximum tolerated dose (MTD) of EZN-3892 (30 mg/kg). Drug effect on tumor numbers, β-catenin protein expression, and nuclear β-catenin localization were determined. Results: Although the tumor phenotype and β-catenin nuclear localization in Min/+ mice did not change following drug administration, we observed a decrease in β-catenin expression levels in the mature intestinal tissue of treated Min/+ and WT mice, providing proof of principle regarding successful delivery of the LNA-based antisense vehicle. Higher doses of EZN-3892 resulted in fatal outcomes in Min/+ mice, likely due to β-catenin ablation in the intestinal tissue and loss of function. Conclusions: Our data support the critical role of Wnt/β-catenin signaling in maintaining intestinal homeostasis and highlight the challenges of effective drug delivery to target disease without permanent

  16. Fast-ion transport in q{sub min}>2, high-β steady-state scenarios on DIII-D

    Holcomb, C. T. [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Heidbrink, W. W.; Collins, C. [Department of Physics and Astronomy, University of California Irvine, Irvine, California 92697 (United States); Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Bass, E. M.; Luce, T. C.; Pace, D. C. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Solomon, W. M.; Mueller, D.; Grierson, B.; Podesta, M. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 05843 (United States); Gong, X.; Ren, Q. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Park, J. M.; Kim, K. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States); Turco, F. [Columbia University, 2960 Broadway, New York, New York 10027 (United States)

    2015-05-15

    Results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-q{sub min} confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β{sub N} and the noninductive current drive. However, in scenarios with q{sub min}>2 that target the typical range of q{sub 95}= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable β{sub N}. In contrast, similar plasmas except with q{sub min} just above 1 have approximately classical fast-ion transport. Experiments that take q{sub min}>3 plasmas to higher β{sub P} with q{sub 95}= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-q{sub min} scenario, the high β{sub P} cases have shorter slowing-down time and lower ∇β{sub fast}, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β{sub N}, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q{sub 95}, high-q{sub min} plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.

  17. Evaluation of mosaic pattern areas in HRCT with Min-IP reconstructions in patients with pulmonary hypertension: Could this evaluation replace lung perfusion scintigraphy?

    Purpose: The aim of this study is to evaluate a possible correlation between areas of lung attenuation, found in minimum intensity projection (Min-IP) reconstruction images performed with high resolution computed tomography without contrast medium (HRCT), and areas of lung perfusion alteration, found in lung perfusion scintigraphy (LPS). Materials and methods: Two independent radiologists, unaware of LPS results, evaluated retrospectively a group of 113 patients affected by pulmonary hypertension (HP) of different aetiology. These have been examined in a period of two years in our centre both by spiral computed tomography (CT) with and without contrast-medium and by LPS. The final diagnosis was determined on clinical data, right heart catheterisation and contrast enhanced CT in angiographic phase (CTPA). We reconstructed the Min-IP images of lung parenchyma in all the cases both in HRCT without contrast-medium, and in contrast enhanced CT in angiographic phase (CTPA) in axial, sagittal and coronal planes. The obtained images were qualitatively graded into three categories of pulmonary attenuation: homogeneous, inhomogeneous with non-segmental patchy defects, inhomogeneous with segmental defects. The same criteria of classification were used also for LPS images. In the group of patients with chronic thromboembolic pulmonary hypertension (CTEPH) we also compared the number of areas of lung attenuation found in Min-IP images in HRCT without contrast-medium, and their exact localization, with not perfused areas in LPS. Gold standard for the diagnosis of pulmonary embolism was spiral contrast enhanced CT in angiographic phase (CTPA). Results: In all cases we found exact correspondence between the Min-IP images in HRCT with and without contras agent. The attenuation pattern seen on Min-IP images was concordant with those of LPS in 96 out of 113 patients (85%). In the remaining 17 cases (15%) it was discordant: in 12 cases inhomogeneous in Min-IP images (7 with non

  18. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSat: instrument characterization techniques, instrument capabilities and solar science objectives.

    Moore, Christopher; Caspi, Amir; Woods, Thomas N.; Mason, James

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3U CubeSat launched in December 2015 to the International Space Station for deployment in early 2016. MinXSS will utilize a commercial off the shelf (COTS) X-ray spectrometer from Amptek to measure the solar irradiance from 0.5 – 30 keV with a nominal 0.15 keV FWHM spectral resolution at 5.9 keV and a LASP developed X-ray photometer with similar spectral sensitivity. MinXSS design and development has involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder.The majority of previous solar X-ray measurements have been either at high spectral resolution with a narrow bandpass or spectrally integrating (broad band) photometers. MinXSS will conduct unique soft X-ray measurements of moderate spectral resolution over a relatively large energy range to study solar active region evolution, solar flares, and their effects on Earth’s ionosphere. This presentation focuses on the science instrument characterization involving radioactive X-ray sources and the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF). Detector spectral response, spectral resolution, response linearity are discussed as well as future solar science objectives.

  19. Heating cells in acid methanol for 30 min without freeze-drying provides adequate yields of fatty acids and alcohols for gas chromatographic characterization of mycobacteria.

    Jimenez, J; Larsson, L

    1986-01-01

    We studied the release of mycobacterial fatty acids (as methyl esters) and secondary alcohols after heating both wet and freeze-dried cells in methanolic hydrogen chloride for different time periods. A 30-min heating of the mycobacteria without prior freeze-drying was found adequate in a routine gas chromatographic procedure for strain and species characterization.

  20. Candidate serum biomarkers for early intestinal cancer using 15N metabolic labeling and quantitative proteomics in the ApcMin/+ mouse.

    Ivancic, Melanie M; Huttlin, Edward L; Chen, Xiaodi; Pleiman, Jennifer K; Irving, Amy A; Hegeman, Adrian D; Dove, William F; Sussman, Michael R

    2013-09-01

    Current screening procedures for colorectal cancer are imperfect and highly invasive and result in increased mortality rates due to low compliance. The goal of the experiments reported herein is to identify potential blood-based biomarkers indicative of early stage intestinal cancers using the ApcMin/+ mouse model of intestinal cancer as an experimental system. Serum proteins from tumor-bearing ApcMin/+ mice were quantitatively compared to tumor-free Apc+/+ wild-type mice via in anima metabolic labeling with 14N/15N-labeled Spirulina algae and an LTQ Orbitrap mass spectrometer. Out of 1116 total serum proteins quantified, this study identified 40 that were differentially expressed and correlated with the increase in intestinal neoplasms. A subset of these differentially expressed proteins underwent a secondary quantitative screen using selected reaction monitoring-mass spectrometry with stable isotope-labeled peptides. Using both quantitative techniques, we identified MGAM and COL1A1 as downregulated and ITIH3 and F5 as upregulated in serum. All but COL1A1 were similarly differentially expressed in the mRNA of neoplastic colonic tissues of ApcMin/+ mice compared to normal wild-type tissue. These differentially expressed proteins identified in the ApcMin/+ mouse model have provided a set of candidate biomarkers for future validation screens in humans. PMID:23924158

  1. 114mIn, a candidate for radionuclide therapy: low-energy cyclotron production and labeling of DTPA-D-Phe-octreotide

    A method for production of carrier-free 114mIn (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium (114Cd) foils, each 50 μm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0.8 MBq/μAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306 deg. C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was 114mIn production gave 114mIn with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [114mIn]- and [111In]-DTPA-D-Phe1-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide

  2. A Study on the Construction of Ecological Protective Screen System in the Arid Valley Area of the Upper Reaches of the Min River

    Zhao Bin

    2015-01-01

    The Min River is a large tributary in the upper reaches of the Yangtze River. Its source is the south range of the Min Mountains in the area where Sichuan and Gansu share a bounda ̄ry. The area consists of five counties in the Aba Tibetan-Qiang Autonomous Prefecture, including Wenchuan, Lixian, Maoxian, Songpan, and He ̄ishui. The area covers 25,426 square kilometers. The area in the upper reaches of the Min River is an arid valley, and its ecological position is very important. This area is not only one that is home to world heritage and national scenic spots, but it is also a poor ethnic minority area with relatively backward economic conditions. Moreover,it is also an important ecological screen and water source for the Chengdu plain,as well as an important part of the ecological protective screen in the upper rea ̄ches of the Yangtze River. As a result of natural disasters,pressure on the carrying capacity of the population and the careless manner of economic development,the resources and environment in this area have been exploited irrationally. This has cre ̄ated a series of serious environmental problems,in ̄cluding environmental pollution, and depletion of resources,etc. Therefore, constructing an ecologi ̄cal protective screen in the upper reaches of the Min River becomes very important.

  3. A novel method for the multiplexed target enrichment of MinION next generation sequencing libraries using PCR-generated baits

    Karamitros, Timokratis; Magiorkinis, Gkikas

    2015-01-01

    The enrichment of targeted regions within complex next generation sequencing libraries commonly uses biotinylated baits to capture the desired sequences. This method results in high read coverage over the targets and their flanking regions. Oxford Nanopore Technologies recently released an USB3.0-interfaced sequencer, the MinION. To date no particular method for enriching MinION libraries has been standardized. Here, using biotinylated PCR-generated baits in a novel approach, we describe a simple and efficient way for multiplexed enrichment of MinION libraries, overcoming technical limitations related with the chemistry of the sequencing-adapters and the length of the DNA fragments. Using Phage Lambda and Escherichia coli as models we selectively enrich for specific targets, significantly increasing the corresponding read-coverage, eliminating unwanted regions. We show that by capturing genomic fragments, which contain the target sequences, we recover reads extending targeted regions and thus can be used for the determination of potentially unknown flanking sequences. By pooling enriched libraries derived from two distinct E. coli strains and analyzing them in parallel, we demonstrate the efficiency of this method in multiplexed format. Crucially we evaluated the optimal bait size for large fragment libraries and we describe for the first time a standardized method for target enrichment in MinION platform. PMID:26240383

  4. The Use of the 6-Min Walk Test as a Proxy for the Assessment of Energy Expenditure during Gait in Individuals with Lower-Limb Amputation

    Kark, Laurena; McIntosh, Andrew S.B; Simmons, Annea

    2011-01-01

    The objective of this study was to determine, and compare, the utility of the 6-min walk test (6 MWT) and self-selected walking speed over 15 m as proxies for the assessment of energy expenditure during gait in individuals with lower-limb amputation. Patients with unilateral, transfemoral amputation (n = 6) and patients with unilateral,…

  5. A novel method for the multiplexed target enrichment of MinION next generation sequencing libraries using PCR-generated baits.

    Karamitros, Timokratis; Magiorkinis, Gkikas

    2015-12-15

    The enrichment of targeted regions within complex next generation sequencing libraries commonly uses biotinylated baits to capture the desired sequences. This method results in high read coverage over the targets and their flanking regions. Oxford Nanopore Technologies recently released an USB3.0-interfaced sequencer, the MinION. To date no particular method for enriching MinION libraries has been standardized. Here, using biotinylated PCR-generated baits in a novel approach, we describe a simple and efficient way for multiplexed enrichment of MinION libraries, overcoming technical limitations related with the chemistry of the sequencing-adapters and the length of the DNA fragments. Using Phage Lambda and Escherichia coli as models we selectively enrich for specific targets, significantly increasing the corresponding read-coverage, eliminating unwanted regions. We show that by capturing genomic fragments, which contain the target sequences, we recover reads extending targeted regions and thus can be used for the determination of potentially unknown flanking sequences. By pooling enriched libraries derived from two distinct E. coli strains and analyzing them in parallel, we demonstrate the efficiency of this method in multiplexed format. Crucially we evaluated the optimal bait size for large fragment libraries and we describe for the first time a standardized method for target enrichment in MinION platform. PMID:26240383

  6. Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate

    Cataldo, L. R.; Olmos, P.; Galgani, J. E.; Valenzuela, R.; Aranda, E.; Cortés, V. A.; Santos, J. L.

    2016-01-01

    High circulating nonesterified fatty acids (NEFAs) concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS) through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression of the serotonin receptor Htr2c, affecting insulin secretion. Additionally, the expression of monoamine-oxidase type B (Maob) seems to be lower in islets from humans and mice with diabetes compared to nondiabetic islets, which may lead to increased monoamine concentrations. We assessed the expression of serotonin- and dopamine-related genes in islets from db/db and wild-type (WT) mice. In addition, the effect of palmitate and oleate on the expression of such genes, 5HT content, and GSIS in MIN6 β-cell was determined. Lower Maob expression was found in islets from db/db versus WT mice and in MIN6 β-cells in response to palmitate and oleate treatment compared to vehicle. Reduced 5HT content and impaired GSIS in response to palmitate (−25%; p < 0.0001) and oleate (−43%; p < 0.0001) were detected in MIN6 β-cells. In conclusion, known defects of GSIS in islets from db/db mice and MIN6 β-cells treated with NEFAs are accompanied by reduced Maob expression and reduced 5HT content. PMID:27366756

  7. Complicating Culture and Difference: Situating Asian American Youth Identities in Lisa Yee's "Millicent Min," "Girl Genius" and "Stanford Wong Flunks Big-Time"

    Endo, Rachel

    2009-01-01

    This review situates how culture, difference, and identity are discursively constructed in "Millicent Min, Girl Genius" and "Stanford Wong Flunks Big-Time," two award-winning books written by critically acclaimed Asian American author Lisa Yee. Using contextual literacy approaches, the characters, cultural motifs, and physical settings in these…

  8. The Min Guo Conservatism in the Perspective of Modernity%现代性视域下的民国保守主义

    徐旭

    2015-01-01

    The birth of the Min Guo Conservatism began with the reflection on modernization, especial-ly on westernization.The first ten years, the second ten years and the last eighteen years of Min Guo were respectively the birth period, prosperity period and maturation period of the Min Guo Conservatism.The Min Guo Conservatives opposed radicalists’ wholesale westernized scheme of establishing new-culture and ways of constructing modernization by complete imitation of western culture and abandoning tradition-al culture.But, at the same time, they contributed themselves to establishing new culture and construc-ting modernization.And in essence, the Min Guo Conservatism’ s opinions were critical discourses full of aesthetic modernity and reflective modernization.%民国保守主义的诞生始于对现代化———尤其是西方化的反思,而民国的第一个十年、第二个十年和最后十八年分别是民国保守主义的萌发期、勃兴期和成熟期。民国保守主义者反对激进主义那种全面仿习西方文化及彻底抛弃传统文化而全盘西化的新文化建构方案和现代化建设方式,但他们也同样致力于新文化建构和现代化建设。从本质上说,民国保守主义是极富审美现代性的反思现代化的批判性言说。

  9. Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, open-label, crossover pilot study.

    Hashimoto, Yoshitaka; Tanaka, Muhei; Okada, Hiroshi; Mistuhashi, Kazuteru; Kimura, Toshihiro; Kitagawa, Noriyuki; Fukuda, Takuya; Majima, Saori; Fukuda, Yukiko; Tanaka, Yoshimitsu; Yamada, Shunji; Senmaru, Takafumi; Hamaguchi, Masahide; Asano, Mai; Yamazaki, Masahiro; Oda, Yohei; Hasegawa, Goji; Nakamura, Naoto; Fukui, Michiaki

    2016-05-01

    Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism. As an animal model, 18 Zucker-rats were divided into three groups as follows: no medication (Control), metformin (600 mg/kg) with meal (Met), and metformin 10 min before meal (pre-Met). In addition, five diabetic patients were recruited and randomized to take metformin (1000 mg) either 30 min before a meal (pre-Met protocol) or with a meal (Met protocol). In the animal model, the peak glucose level of pre-Met (7.8 ± 1.5 mmol/L) was lower than that of Control (12.6 ± 2.5 mmol/L, P = 0.010) or Met (14.1 ± 2.9 mmol/L, P = 0.020). Although there was no statistical difference among the three groups, total GLP-1 level at t = 0 min of pre-Met (7.4 ± 2.7 pmol/L) tended to be higher than that of Control (3.7 ± 2.0 pmol/L, P = 0.030) or Met (3.9 ± 1.2 pmol/L, P = 0.020). In diabetic patients, the peak glucose level of pre-Met protocol (7.0 ± 0.4 mmol/L) was lower than that of Met protocol (8.5 ± 0.9 mmol/L, P = 0.021). Total GLP-1 level at t = 30 min of pre-Met protocol (11.0 ± 6.1 pmol/L) was higher than that of Met protocol (6.7 ± 3.9 pmol/L, P = 0.033). Taking metformin 30 min before a meal ameliorated postprandial hyperglycemia. This promises to be a novel approach for postprandial hyperglycemia. PMID:26518190

  10. Analysis of Highly Nonlinear Oscillation System Using He's Max-Min Method and Comparison with Homotopy Analysis Method and Energy Balance Methods

    Ibsen, Lars Bo; Barari, Amin; Kimiaeifar, Amin

    2010-01-01

    of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to......Nonlinear functions are crucial points and terms in engineering problems and the solutions of many important physical problems are centered on finding accurate solutions to these functions. In this paper, a new method called max–min method has been presented for deriving accurate....../approximate analytical solution to strong nonlinear oscillators. Furthermore, it is shown that a large class of linear or nonlinear differential equations can be solved without the tangible restriction of sensitivity to the degree of the nonlinear term, adding that the method is quite convenient due to reduction in size...

  11. Analysis of Highly Nonlinear Oscillation Systems Using He’s Max-Min Method and Comparison with Homotopy Analysis and Energy Balance Methods

    Ibsen, Lars Bo; Barari, Amin; Kimiaeifar, Amin

    2010-01-01

    of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to......Nonlinear functions are crucial points and terms in engineering problems and the solutions of many important physical problems are centered on finding accurate solutions to these functions. In this paper, a new method called max–min method has been presented for deriving accurate....../approximate analytical solution to strong nonlinear oscillators. Furthermore, it is shown that a large class of linear or nonlinear differential equations can be solved without the tangible restriction of sensitivity to the degree of the nonlinear term, adding that the method is quite convenient due to reduction in size...

  12. Development, preparation and control of sup(99m)Tc or sup(113m)In labelled stannous hydroxide radiopharmaceuticals. Part of a coordinated programme on radiopharmaceuticals

    The preparation of different sup(99m)Tc and sup(113m)In radiopharmaceuticals using stannous chloride was investigated. Chemical and radiochemical procedures for the quality control of these preparations were studied. Toxicity and biological controls of the preparation were carried out. Procedures for the preparation and control of the following radiopharmaceuticals have been standardized by the authors; albumin macroaggregates labelled with sup(99m)Tc, sup(113m)In and other isotopes for lung scanning; albumin microspheres labelled with sup(99m)Tc for lung scanning; sup(99m)Tc or sup(113m)In-labelled stannous hydroxide colloid for liver scanning; sup(99m)Tc-stannous phytate for liver scanning; sup(99m)Tc-Sn-dextrose, a new radiopharmaceutical which has been proposed by the authors and is now used in Mexico for renal and cerebral scanning and sup(99m)Tc-Sn pyrophosphate and diphosphonate for bone scanning

  13. Analysis of highly nonlinear oscillation systems using He’s max–min method and comparison with homotopy analysis and energy balance methods

    L B Ibsen; A Barari; A Kimiaeifar

    2010-08-01

    Nonlinear functions are crucial points and terms in engineering problems and the solutions of many important physical problems are centered on finding accurate solutions to these functions. In this paper, a new method called max–min method has been presented for deriving accurate/approximate analytical solution to strong nonlinear oscillators. Furthermore, it is shown that a large class of linear or nonlinear differential equations can be solved without the tangible restriction of sensitivity to the degree of the nonlinear term, adding that the method is quite convenient due to reduction in size of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to show the stability of systems is plotted and discussed.

  14. Estratégia de controle de qualidade de minérios na lavra utilizando simulação geoestatística

    Fernando Gambin

    2005-09-01

    Full Text Available Novas centrais térmicas utilizam carvão ROM (run of mine na geração de energia termoelétrica. Assim, flutuações de qualidade do carvão serão transferidas da mina para o consumidor final. Contratos entre produtor-consumidor estabelecem limites para parâmetros geológicos e tecnológicos do produto final (minério ROM. O descumprimento dos limites estabelecidos gera penalização e/ou rejeição de lotes de minério. O custo elevado dessas penalizações recomenda o controle de qualidade do minério no produto final. A utilização de técnicas geoestatísticas visa a caracterizar a qualidade e a variabilidade do minério a ser lavrado. Tradicionalmente, essa estratégia utiliza um modelo de blocos gerado por um estimador tradicional, geralmente krigagem ordinária. A estimativa dos blocos por krigagem não considera a incerteza associada ao modelo geológico, não sendo adequada para prever flutuações locais. Diferente da krigagem, os métodos de simulação geoestatística têm como objetivo reproduzir a variabilidade in situ e a continuidade espacial dos dados originais. Uma vez que os teores e sua variabilidade são estimados, flutuações da qualidade do minério podem ser previstas para determinada rota de lavra e certo tamanho de lote entregue ao consumidor. Diferentes tamanhos de lote são testados a fim de obter-se o controle das flutuações da qualidade do minério. Esse procedimento é aplicado em um estudo de caso em mineração subterrânea de carvão no sul do Brasil. A utilização de simulação geoestatística possibilida acessar a incerteza associada à qualidade de determinado volume de minério no depósito.The new generation of coal fired power plants in Brazil are expected to use ROM coal as fuel. Thus, variations of coal quality tend to be transferred from mine to the final user. Contracts frequently establish max-min limits for geological and technological parameters. Lots of ore with quality beyond the agreed

  15. Flotação aniônica de rejeito de minério de manganês Anionic flotation of tailings of manganese ore

    Rosa Malena Fernandes Lima; João Antônio Vasconcelos; Gláucia Regina da Silva

    2008-01-01

    Normalmente, os fluxogramas brasileiros, tanto para o beneficiamento de minérios ricos, quanto para minérios complexos de manganês, consistem, basicamente, de fragmentação e classificação granulométrica, com o descarte da fração abaixo de 0,106mm. Logo, é muito importante para a indústria mineral desenvolver fluxogramas e processos de concentração dessas frações granulométricas, visando ao aumento da recuperação global de manganês, bem como à redução do impacto ambiental, gerado com o descart...

  16. Din, Min og Alles fest

    Jakobsen, Sofie Damgaard; Pedersen, Maria Haarbye; Ahlbom, Anna Lohmann

    2012-01-01

    The project aims to investigate whether nudging can serve as a possible solution to Distortions waste problem. To investigate this we will use the Thaler and Sunstein nudge theory combining the underlying dual process theory for a self-selected nudge. Furthermore the project will discuss the use of libertarian paternalism as a composite concept. The project concludes that a chosen nudge can have an effect in terms of signal value, but does not function as a comprehensive solution to th...

  17. Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.

    Welsh, Patricia A; Sass-Kuhn, Suzanne; Prakashagowda, Chethana; McCloskey, Diane; Feith, David

    2012-04-01

    Numerous studies have demonstrated a link between elevated polyamine biosynthesis and neoplastic growth, but the specific contribution of spermine synthase to epithelial tumor development has never been explored in vivo. Mice with widespread overexpression of spermine synthase (CAG-SpmS) exhibit decreased spermidine levels, increased spermine and a significant rise in tissue spermine:spermidine ratio. We characterized the response of CAG-SpmS mice to two-stage skin chemical carcinogenesis as well as spontaneous intestinal carcinogenesis induced by loss of the Apc tumor suppressor in Apc (Min) (/+) (Min) mice. CAG-SpmS mice maintained the canonical increases in ornithine decarboxylase (ODC) activity, polyamine content and epidermal thickness in response to tumor promoter treatment of the skin. The induction of S-adenosylmethionine decarboxylase (AdoMetDC) activity and its product decarboxylated AdoMet were impaired in CAG-SpmS mice, and the spermine:spermidine ratio was increased 3-fold in both untreated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated skin. The susceptibility to 7,12-dimethylbenz[a]anthracene (DMBA)/TPA skin carcinogenesis was not altered in CAG-SpmS mice, and SpmS overexpression did not modify the previously described tumor resistance of mice with targeted antizyme expression or the enhanced tumor response in mice with targeted spermidine/spermine-N ( 1) -acetyltransferase expression. CAG-SpmS/Min mice also exhibited elevated spermine:spermidine ratios in the small intestine and colon, yet their tumor multiplicity and size was similar to Min mice. Therefore, studies in two of the most widely used tumorigenesis models demonstrate that increased spermine synthase activity and the resulting elevation of the spermine:spermidine ratio does not alter susceptibility to tumor development initiated by c-Ha-Ras mutation or Apc loss. PMID:22258329

  18. The Pseudomonas syringae pv. tomato type III effector HopM1 suppresses Arabidopsis defenses independent of suppressing salicylic acid signaling and of targeting AtMIN7.

    Anju Gangadharan

    Full Text Available Pseudomonas syringae pv tomato strain DC3000 (Pto delivers several effector proteins promoting virulence, including HopM1, into plant cells via type III secretion. HopM1 contributes to full virulence of Pto by inducing degradation of Arabidopsis proteins, including AtMIN7, an ADP ribosylation factor-guanine nucleotide exchange factor. Pseudomonas syringae pv phaseolicola strain NPS3121 (Pph lacks a functional HopM1 and elicits robust defenses in Arabidopsis thaliana, including accumulation of pathogenesis related 1 (PR-1 protein and deposition of callose-containing cell wall fortifications. We have examined the effects of heterologously expressed HopM1Pto on Pph-induced defenses. HopM1 suppresses Pph-induced PR-1 expression, a widely used marker for salicylic acid (SA signaling and systemic acquired resistance. Surprisingly, HopM1 reduces PR-1 expression without affecting SA accumulation and also suppresses the low levels of PR-1 expression apparent in SA-signaling deficient plants. Further, HopM1 enhances the growth of Pto in SA-signaling deficient plants. AtMIN7 contributes to Pph-induced PR-1 expression. However, HopM1 fails to degrade AtMIN7 during Pph infection and suppresses Pph-induced PR-1 expression and callose deposition in wild-type and atmin7 plants. We also show that the HopM1-mediated suppression of PR-1 expression is not observed in plants lacking the TGA transcription factor, TGA3. Our data indicate that HopM1 promotes bacterial virulence independent of suppressing SA-signaling and links TGA3, AtMIN7, and other HopM1 targets to pathways distinct from the canonical SA-signaling pathway contributing to PR-1 expression and callose deposition. Thus, efforts to understand this key effector must consider multiple targets and unexpected outputs of its action.

  19. Effects of Kapton Sample Cell Windows on the Detection Limit of Smectite: Implications for CheMin on the Mars Science Laboratory Mission

    Achilles, C. N.; Ming, Douglas W.; Morris, R. V.; Blake, D. F.

    2012-01-01

    The CheMin instrument on the Mars Science Laboratory (MSL) rover Curiosity is an X-ray diffraction (XRD) and X-ray fluorescence (XRF) instrument capable of providing the mineralogical and chemical compositions of rocks and soils on the surface of Mars. CheMin uses a microfocus X-ray tube with a Co target, transmission geometry, and an energy-discriminating X-ray sensitive CCD to produce simultaneous 2-D XRD patterns and energy-dispersive X-ray histograms from powdered samples. CheMin has two different window materials used for sample cells -- Mylar and Kapton. Instrument details are provided elsewhere. Fe/Mg-smectite (e.g., nontronite) has been identified in Gale Crater, the MSL future landing site, by CRISM spectra. While large quantities of phyllosilicate minerals will be easily detected by CheMin, it is important to establish detection limits of such phases to understand capabilities and limitations of the instrument. A previous study indicated that the (001) peak of smectite at 15 Ang was detectable in a mixture of 1 wt.% smectite with olivine when Mylar is the window material for the sample cell. Complications arise when Kapton is the window material because Kapton itself also has a diffraction peak near 15 Ang (6.8 deg 2 Theta). This study presents results of mineral mixtures of smectite and olivine to determine smectite detection limits for Kapton sample cells. Because the intensity and position of the smectite (001) peak depends on the hydration state, we also analyzed mixtures with "hydrated" and "dehydrated"h smectite to examine the effects of hydration state on detection limits.

  20. Monitoring and forecasting of radiation hazard from great solar energetic particle events by using on-line one-min neutron monitor and satellite data

    The method of automatically determining the start of great solar energetic particle (SEP) events are described on the basis of cosmic ray (CR) one-min observations by neutron monitors in real-time scale. It is shown that the probabilities of false alarms and missed triggers are negligible. After the start of SEP event, it is automatically determined by the method of coupling functions the SEP energy spectrum and flux for each minute of observations. By solving the inverse problem during few first minutes of SEP event, diffusion coefficient in the interplanetary space, source function on the Sun, and time of ejection of SEP into solar wind are determined. For extending obtained results into small energy range we use also available from Internet the satellite one-min CR data. This make possible to give forecast of space-time variation of SEP for more than 2 days and estimate expected radiation dose for satellite and aircraft. With each new minute of observations, the quality of forecast increased, and after ∼30 min became near 100%. (authors)

  1. Pozitif psikoloji yaklaşımıyla mü’min insanın kişilik özellikleri

    CEYLAN, İsa

    2013-01-01

    Ceylan, İsa, Pozitif Psikoloji Yaklaşımıyla Mü’min İnsanın Kişilik Özellikleri, Yüksek Lisans Tezi, Danışman: Prof. Dr. Öznur Özdoğan, Ankara Üniversitesi Sosyal Bilimler Enstitüsü – 2013, 180 s. Bu çalışmada İslam terminolojisinde tanımlanan “mü’min”in kişilik özelliklerini araştırdık. “Mü’min insan kişiliği” araştırılırken Pozitif Psikoloji bakış açısından yararlandık. Mü’min insanın; her şeyin güzel taraflarını gören, hayata pozitif bakan, her an insanlara ve Allah’a güven veren v...

  2. A Prediction Method for△f0F2min of a Single Station From Interplanetary Parameters Based on Statistical Study

    LI Zheng; WEI Fengsi; FENG Xueshang; GUO Jianpeng; XU Xiaojun

    2012-01-01

    Using 86 CME-interplanetary shock events,the correlation between the peak values of (a) the solar wind parameters(Bz,Ey,Pdyn) and the geomagnetic indices(SYM-H,ASY-H,Kp), (b) the coupling functions(Borovsky,Akasofu,Newell) and the geomagnetic indices,(c) the solar wind parameters/coupling functions/geomagnetic indices and the ionospheric parameter(△f0F2min), are investigated.The statistical results show that in group(a),Bz min and SYM-Hmin have the best correlation,that in group(b),the best correlation is between the peak values of Akasofu function (Amin) and SYM-Hmin,and that in group(c),the best correlation is between (pmax and △f0F2min). Based on the statistical results,a method for predicting f0F2 of a single station is attempted to be set up.The input is modified B_(z min) and the outputs are SYM-Hmin and △f0F2min.Then 25 CME-IPS events that caused geomagnetic storms in 1998 and 2009 are used to check the prediction method. The results show that our method can be used to predict SYM-Hmin and △f0F2min

  3. Alveográfos mérések az őszi búza minőségvizsgálatában

    Pongraczne Barancsi, Agnes

    2010-01-01

    Magyarországon az utóbbi néhány évben kardinális szerepet kap a jó minőségű búza előállítása, mely mind elméletében, mind gyakorlatában jelentős felkészültséget igényel. Az őszi búza minőségvizsgálatakor elsősorban a külföldi, de egyre gyakrabban a hazai vásárlók is igénylik az alveográfos paraméterek megadását is. A „Pannon†minőségnek fontos paraméterei az alveográfos W és P/Lértékek. Acsekély számú hazai és külföldi szakirodalmi adatok, valamint saját tapasztalataink és vevőink igénye a...

  4. Transcription of TIR1-Controlled Genes Can be Regulated within 10 Min by an Auxin-Induced Process. Can TIR1 be the Receptor?

    Labusch, Corinna; Effendi, Yunus; Fulda, Martin; Scherer, Günther F E

    2016-01-01

    ABP1 and TIR1/AFBs are known as auxin receptors. ABP1 is linked to auxin responses several of which are faster than 10 min. TIR1 regulates auxin-induced transcription of early auxin genes also within minutes. We use transcription of such TIR1-dependent genes as indicator of TIR1 activity to show the rapid regulation of TIR1 by exogenous auxin. To this end, we used quantification of transcription of a set of fifteen early auxin-induced reporter genes at t = 10 and t = 30 min to measure this as a TIR1-dependent auxin response. We conducted this study in 22 mutants of auxin transporters (pin5, abcb1, abcb19, and aux1/lax3), protein kinases and phosphatases (ibr5, npr1, cpk3, CPK3-OX, d6pk1, d6pkl1-1, d6pkl3-2, d6pkl1-1/d6pkl2-2, and d6pkl1-1/d6pkl3-2), of fatty acid metabolism (fad2-1, fad6-1, ssi2, lacs4, lacs9, and lacs4/lacs9) and receptors (tir1, tir1/afb2, and tir1/afb3) and compared them to the wild type. After 10 min auxin application, in 18 out of 22 mutants mis-regulated expression of at least one reporter was found, and in 15 mutants transcription of two-to-three out of five selected auxin reporter genes was mis-regulated. After 30 min of auxin application to mutant plants, mis-regulation of reporter genes ranged from one to 13 out of 15 tested reporter genes. Those genes chosen as mutants were themselves not regulated in their expression by auxin for at least 1 h, excluding an influence of TIR1/AFBs on their transcription. The expression of TIR1/AFB genes was also not modulated by auxin for up to 3 h. Together, this excludes a feedback or feedforward of these mutant genes/proteins on TIR1/AFBs output of transcription in this auxin-induced response. However, an auxin-induced response needed an as yet unknown auxin receptor. We suggest that the auxin receptor necessary for the fast auxin-induced transcription modulation could be, instead, ABP1. The alternative hypothesis would be that auxin-induced expression of a protein, initiated by TIR1/AFBs receptors

  5. A Study on the First Issue Date ofMin Sheng Daily in Nanjing%南京《民生报》发刊日考

    黄志辉

    2012-01-01

    目前文献中关于南京《民生报》何时发刊可说是众说纷纭,莫衷一是,本文就此问题略作探究,辨析已有的几种代表性说法,分析考证相关文献,以辩证出正确的发刊日。%When Min Sheng Daily in Nanjing first issued remains as a dispute, This paper analyzes the representative opinions on this question, and tries to find out the first issue date through the relevant documents.

  6. GrafoMin: una herramienta para el aprendizaje y la construcción del camino más corto entre dos nodos de un grafo

    Iglesias Bello, Gustavo Adolfo

    2012-01-01

    GrafoMin es el nombre de una herramienta gráfica para el aprendizaje y la construcción del camino más corto entre dos nodos (o vértices) de un grafo. Esta herramienta puede ser utilizada tanto por los estudiantes, en el proceso de aprendizaje usando el algoritmo de Dijsktra y como prueba de auto-evaluación, así como por los profesores que deseen impartir dicha materia. El usuario puede crear el grafo a su gusto: añadiendo tantos vértices y aristas como desee, indicando los vértices inicial y ...

  7. Generator 113Sn-sup(113m)In. Study of the most important characteristics in the eluate composition for the preparation of clinical labelled compounds

    The design for the construction of a generator 113Sn-sup(113m)In is described. A systematic assay for the adequate adsorbents has been made, to obtain solutions of high radiochemical purity, as it is required for the radiopharmaceutical preparations. The control of purity is carried on by qualitative and quantitative analysis of the solutions, complemented by radiochemical techniques. The following physico-chemical parameters have been determinated; consecutive equilibrium constants, pH, distribution constants, separation factors and electrophoretic factors. It has been considered the measure of these parameters for the best quality in the preparation of the radiopharmaceutical compounds. (author)

  8. Les consommations d'énergie dans l'industrie minérale (résumé Energy Consumption in the Mineral Industry (Summary

    Gentilhomme P. H.

    2006-11-01

    Full Text Available Dans le cadre limité de cette présentation, il était préférable de placer l'accent, non sur les évaluations du coût énergétique des diverses substances minérales, mais plutôt sur les paramètres de ces coûts, leur évolution récente et leur devenir dans une prospective à moyen terme, questions susceptibles d'alimenter ensuite les discussions. Après un bref rappel méthodologique, seront successivement examinés : - d'un point de vue global, la consommation d'énergie de l'industrie minérale, sa répartition et son évolution par formes d'énergie mises en oeuvre ; - d'un point de vue analytique, la nature des facteurs qui régissent les coûts énergétiques miniers, minéralurgiques et métallurgiques, les tendances récentes constatées et leurs implications pour l'avenir ; - d'un point de vue prospectif, enfin, quelques-uns des remèdes - ou palliatifs ? - à l'élévation des coûts énergétiques des substances minérales. Within the required time for the presentation of this paper, it was more advisable to emphasize, not the sizing up of the energy cost of mineral raw materials and products, but rather the parameters of thes costs, and their evolution, actual and in a medium-term prospective, questions of eventual interest for the discussions. After a short recall of methodology, we have to examine successively: - on a global standpoint, the energy consumption of the mineral industry, the breakdown of this consumption by forms of energy used, and its evolution; - on an analytical standpoint, the main factors which direct the energy requirements in mining, beneficiating and smeltinq operations, the trends that are observed and their results for the future; - on a prospective standpoint, at last, what are the possibilities to cut off - or palliate? - the increase of the mineral commodities energy costs.

  9. A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level

    Caffrey, Deirdre; Miranda, J Jaime; Gilman, Robert H.; Davila-Roman, Victor G.; CABRERA, LILIA; Dowling, Russell; Stewart, Talia; Bernabe-Ortiz, Antonio; Wise, Robert; Leon-Velarde, Fabiola; Checkley, William

    2014-01-01

    Background We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude. Methods We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. ...

  10. Comparative Analyses between Skeletal Muscle miRNAomes from Large White and Min Pigs Revealed MicroRNAs Associated with Postnatal Muscle Hypertrophy

    Sheng, Xihui; Wang, Ligang; Ni, Hemin; Wang, Lixian; Qi, Xiaolong; Xing, Shuhan; Guo, Yong

    2016-01-01

    The molecular mechanism regulated by microRNAs (miRNAs) that underlies postnatal hypertrophy of skeletal muscle is complex and remains unclear. Here, the miRNAomes of longissimus dorsi muscle collected at five postnatal stages (60, 120, 150, 180, and 210 days after birth) from Large White (commercial breed) and Min pigs (indigenous breed of China) were analyzed by Illumina sequencing. We identified 734 miRNAs comprising 308 annotated miRNAs and 426 novel miRNAs, of which 307 could be consider...

  11. Wireless Multi-hop Network Scenario Emulation with MinGenMax Error Based on Interval Equivalent Character of Wireless Communication

    Huizhou Zhao

    2012-12-01

    Full Text Available This paper proposes a novel approach to emulate an arbitrary wireless multi-hop network scenario in a fixed wireless test-bed, in which every node is equipped with a variable attenuator. We take notice of the interval equivalent character of wireless communication and consider the wireless multi-hop scenario emulation problem as an interval equivalent emulation problem. We define the generalized error, which is an error of a value relative to an interval, formulate the MinGenMax (Minimize Generalized Maximum error problem and propose an optimum algorithm.

  12. Ihana kehittyvä minä - Matkalla tytöstä naiseksi : voimavaralähtöistä seksuaaliterveysneuvontaa kuudesluokkalaisille tytöille

    Nieminen, Katariina; Lindholm, Susanna

    2012-01-01

    Nieminen, Katariina & Lindholm, Susanna. Ihana kehittyvä minä – Matkalla tytöstä naiseksi. Voimavaralähtöistä seksuaaliterveysneuvontaa kuudesluokkalaisille tytöille. Diak Etelä, Helsinki, kevät 2012, 73 s., 6 liitettä. Diakonia-ammattikorkeakoulu, Hoitotyön koulutusohjelma, terveydenhoitaja (AMK) ja sairaanhoitaja (AMK). Opinnäytetyön tarkoituksena oli arvioida kuudesluokkalaisten tyttöjen tarvetta opetuksesta erilliselle seksuaaliterveysneuvonnalle ja kehittää voimavaralähtöinen ...

  13. Ostokäyttäytymisen tutkiminen ja segmentointi yhdistysasiakkaille suunnattujen kulttuurimatkailupakettien kehittämiseksi - case Ahlströmin ruukit

    Mäkinen, Siri

    2015-01-01

    Tämän opinnäytetyön tarkoituksena oli tutkia kotimaan kulttuuripalveluita hyödyntävien yhdistysasiakkaiden ostokäyttäytymistä ja ostopäätökseen vaikuttavia asioita. Tulosten pohjalta oli tarkoitus luoda asiakkaista segmenttejä ja antaa toimeksiantajalle kulttuurimatkailupaketteja koskevia kehitysehdotuksia. Tämä opinnäytetyö tehtiin toimeksiantona Ahlströmin ruukkien palveluliiketoiminnalle. Opinnäytetyön teoriaosuudessa selvennettiin lukijalle kulttuurimatkailun ja matkailutuotteen käsi...

  14. Caracterização de minérios: uso do Magstream-Model 100, suas vantagens e limitações

    Maria José Gazzi Salum

    2002-03-01

    Full Text Available O presente trabalho discute a importância da caracterização de minérios como suporte para o entendimento do comportamento de seus minerais frente a processos de tratamento de minérios, controle de processos e controle da qualidade dos produtos obtidos. É, também, apresentada uma breve revisão da literatura sobre as principais técnicas de caracterização, incluindo aquelas utilizadas para a separação de minerais de um minério. Especial atenção foi dada à técnica de separação de minerais de um minério, utilizando um equipamento chamado Magstream-Model 100. O trabalho mostra que o processo Magstream, que envolve o uso de fluido magnético como meio separador, campo magnético e um sistema de rotação, oferece vantagens em relação a outras técnicas, como, por exemplo, a de líquidos densos. Entretanto o processo utilizado pelo Magstream leva a mudanças em propriedades de superfície dos minerais, modificando seus comportamentos frente à flotação. Esse fato foi considerado como uma limitação de seu uso, quando estudos posteriores com os minerais processados no Magstream envolvem propriedades de superfície.This paper discusses the importance of mineral characterization as a support to understand their behavior in mineral processing and in the control of the processes and quality of the products obtained. Also presented is a brief review on the main techniques used in minerals characterization, including the procedures for minerals separation from an ore. Special attention was given to the technique of mineral separation from an ore according to their specific gravities using a device called Magstream-Model 100. It is shown that the Magstream process, which involves the use of a magnetic fluid as a medium for mineral separation, a magnetic field and a rotation speed system, offers advantages compared to the heavy liquids technique. However, the Magstream process leads to changes on mineral surface properties, imparting to

  15. GIS Grid and CWS-based assessment of vulnerability to debris flow hazards in the upper reaches of Min River, China

    Ding, Mingtao; Hübl, Johannes; Fuchs, Sven

    2014-05-01

    Based on conceptual models of vulnerability assessment for mountain hazards, this paper aims to improve a quantitative assessment model for regional vulnerability by a detailed analysis of the relation between and among vulnerability (V), exposure (E), social coping capacity (C) and resilience (Re) with the expression of V = E(1-° C+Re- 2). Taking the mountain settlements in the upper reaches of Min River, China, as an example and ArcGIS 9.3 as the platform, we applied the technology of GIS Grid and the method of Contributing Weight Superposition (CWS) to establish both a model and a system for the vulnerability assessment of elements at risk. The latter consists of 13 index factors including population, economics and road densities, building and farmland coverage, hazard-affected areas, a monitoring coefficient to take into account early warning measures, the urbanization rate, GDP per capita, and labor aged population ratio. Accordingly, a debris-flow hazard vulnerability zoning map has been obtained and the assessment results had shown that the distribution of high and comparatively high vulnerability zones, where economic activities are the most intensive, had a close correlation to the river geometry and geomorphology and population activities. Such results correspond well with loss data in the region, proving the reasonability and feasibility of assessment methods in this paper. The results thus may serve as the pertinent guidance for settlement relocation, population distribution readjustment, and management to prevent and reduce hazards in the upper reaches of Min River.

  16. Linear and nonlinear dynamics of heart rate variability in the process of exposure to 3600 m in 10 min.

    Zhang, Da; She, Jin; Yang, Jun; Yu, Mengsun

    2015-06-01

    Acute hypoxia activates several autonomic mechanisms, mainly in cardiovascular system and respiratory system. The influence of acute hypoxia on linear and nonlinear heart rate variability (HRV) has been studied, but the parameters in the process of hypoxia are still unclear. Although the changes of HRV in frequency domain are related to autonomic responses, how nonlinear dynamics change with the decrease of ambient atmospheric pressure is unknown either. Eight healthy male subjects were exposed to simulated altitude from sea level to 3600 m in 10 min. HRV parameters in frequency domain were analyzed by wavelet packet transform (Daubechies 4, 4 level) followed by Hilbert transform to assess the spectral power of modified low frequency (0.0625-0.1875 Hz, LFmod), modified high frequency (0.1875-0.4375 Hz, HFmod), and the LFmod/HFmod ratio in every 1 min. Nonlinear parameters were also quantified by sample entropy (SampEn) and short term fractal correlation exponent (α1) in the process. Hypoxia was associated with the depression of both LFmod and HFmod component. They were significantly lower than that at sea level at 3600 m and 2880 m respectively (both p altitude. Monitoring linear and nonlinear HRV parameters continuously in the process of hypoxia would be an effective way to evaluate the different regulatory mechanisms of autonomic nervous system. PMID:26088333

  17. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

    Ha Thi Ngo

    2015-01-01

    Full Text Available We studied how obesogenic conditions during various life periods affected obesity and intestinal tumorigenesis in adult C57BL/6J-Min (multiple intestinal neoplasia/+ mice. The mice were given a 10% fat diet throughout life (negative control or a 45% fat diet in utero, during nursing, during both in utero and nursing, during adult life, or during their whole life-span, and terminated at 11 weeks for tumorigenesis (Min/+ or 23 weeks for obesogenic effect (wild-type. Body weight at 11 weeks was increased after a 45% fat diet during nursing, during both in utero and nursing, and throughout life, but had normalized at 23 weeks. In the glucose tolerance test, the early exposure to a 45% fat diet in utero, during nursing, or during both in utero and nursing, did not affect blood glucose, whereas a 45% fat diet given to adults or throughout life did. However, a 45% fat diet during nursing or during in utero and nursing increased the number of small intestinal tumors. So did exposures to a 45% fat diet in adult life or throughout life, but without increasing the tumor numbers further. The intrauterine and nursing period is a window of susceptibility for dietary fat-induced obesity and intestinal tumor development.

  18. Aplicação de prensas de rolos em minério de ferro High pressure grinding rolls for iron ore

    Farley Santos Ribeiro

    2010-06-01

    Full Text Available O Projeto Minas-Rio, de propriedade da Anglo Ferrous Brazil, prevê a utilização de prensa de rolos para cominuição do undersize do peneiramento (-25,4 mm. Esta é uma aplicação que se torna cada dia mais comum, porém relativamente nova em minério de ferro. Foram realizados estudos no Centro de Pesquisa da Krupp/Polysius na Alemanha, com o objetivo de validar a aplicação de prensa de rolos para minério de ferro, de determinar os principais parâmetros usados no dimensionamento e de avaliar o impacto do aumento da umidade da alimentação na capacidade específica e na distribuição granulométrica do produto. Os excelentes resultados obtidos, nos ensaios em escala-piloto, somados aos ganhos financeiros da aquisição e operação, à maior estabilidade do processo diante variações de w i (work index e à distribuição granulométrica da alimentação, contribuíram para aprovar, de forma irrestrita, a aplicação de prensa de rolos para cominuição de minério de ferro no Projeto Minas-Rio.The Minas-Rio Project that is being implemented by Anglo Ferrous Brazil, foresees the use of HPGR (High Pressure Grinding Rolls to grind the undersize from screening at (-25.4 mm. This application is recent for iron ore comminuting. The study described herein, took place at the Krupp/Polysius Research Center, in Germany, aiming to validate the HPGR application for iron ore, as well as to determine the main parameters used in equipment sizing. The study also aimed to assesses the impact of moisture variation on ore feed in respect to specific grinding capacity and product size distribution. The great results obtained from the sample tests that demonstrated more process stability for the work index (w i and granulometric feed distribution variations, together with the possible financial gains from the HPGR implementation, contributed to the unrestricted approval of the HPGR application for iron ore comminuting in the Minas-Rio Project.

  19. Flotação aniônica de rejeito de minério de manganês Anionic flotation of tailings of manganese ore

    Rosa Malena Fernandes Lima

    2008-09-01

    Full Text Available Normalmente, os fluxogramas brasileiros, tanto para o beneficiamento de minérios ricos, quanto para minérios complexos de manganês, consistem, basicamente, de fragmentação e classificação granulométrica, com o descarte da fração abaixo de 0,106mm. Logo, é muito importante para a indústria mineral desenvolver fluxogramas e processos de concentração dessas frações granulométricas, visando ao aumento da recuperação global de manganês, bem como à redução do impacto ambiental, gerado com o descarte desses finos. Nesse trabalho, são apresentados estudos comparativos de flotação aniônica de um rejeito de minério complexo sílico-carbonatado, constituído, principalmente, pelos minerais rodocrosita, rodonita, espessartia clinocloro, quartzo, anita e flogopita, usando os coletores oleato de sódio e sabão de óleo de soja com o depressor silicato de sódio. Através desses estudos, foram verificadas reduções dos teores de SiO2 da alimentação (28,10% de cerca de 11 e 8% para o oleato de sódio e o sabão de óleo de soja, respectivamente em pH 11.The Brazilian processing flowsheet that is used to concentrate both the rich and complex manganese ores is constituted by size reduction and size classification. The particles with size below 0.106mm normally are discharged as waste. So it is very important for the mineral industry to develop flowsheets and processes in order to improve the global manganese recovery and to reduce the environmental impact with these wastes that are deposited on the land. In this work is presented an anionic froth flotation comparative study between two different anionic collectors (sodium oleate and soybean oil soap and sodium silicate depressant to concentrate the silicate-carbonated manganese ore waste that was constituted mainly by rodocrosite, rodonite, espessartite, clinoclore, quartz, annite and flogopite minerals. It was observed that at pH 11 the SiO2 content in the feed (28.1% was reduced

  20. Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in Apc(Min) mice

    van Kranen, H.J.; Mortensen, Alicja; Sørensen, Ilona Kryspin; van den Berg-Wijnands, J.; Beems, R.; Nurmi, T.; Adlercreutz, H.; van Kreijl, C.F.

    2003-01-01

    Phytoestrogens, like isoflavonoids and lignans, have been postulated as possible colorectal cancer protective constituents. To investigate this hypothesis, two high-fiber sources rich in lignan precursors, i.e., rye bran and flaxseed, were tested for their ability to modulate intestinal tumor...... development in Apc(Min) mice. Test diets consisted of a control diet (a Westem-style diet, adjusted for fiber and/or phytate content) supplemented with 5% flaxseed or 30% rye bran. Chemical analysis of diets and blood samples confirmed the enhanced systemic exposure of mice fed the test diets to the major...... immunohistochemical staining for the p53 gene were observed in a set of 48 colon tumors. In conclusion, our results demonstrate that increased intake of lignan precursors from flaxseed or rye bran, administered in a Western-style diet, does not protect against intestinal tumor development in an appropriate animal...

  1. WEN Jian-min and SHI Da-zhuo : ICWM Should Be Taken as A Discipline Uniformly and The Practice Scope of ICWM Practitioners Be Defined

    2010-01-01

    @@ According to the current inconsistent status of subject names and stratification of ICWM and based on the principle of classification that a subject can only use one name and one code, Prof. WEN Jian-min and Prof. SHI Da-zhuo, two CPPCC members, proposed that ICWM in the subject categories of National Standardization Committee (defined as a subdiscipline under CM and Chinese materia medica) and that in the subject categories of the Academic Degree Commission of the State Council (defined as a discipline, consisting of two sub-disciplines, the basic ICWM and the clinical ICWM) should be taken as a discipline uniformly, consisting of 12 subdisciplines, Basic Medicine, Clinical Medicine, Diagnostics, Internal Medicine, Surgery, Orthopaedics, Pediatrics,Ophthalmology, Otorhinolaryngology, Dermatology and Venereology, Obstetrics and Gynecology, and Other Subjects.

  2. Separation of no-carrier-added 113,117mSn and 113m,114mIn from alpha particle irradiated natural cadmium target

    A natural cadmium foil was irradiated by 42 MeV α-particles to produce 113,117mSn, 111,113m,114mIn simultaneously in the target matrix. After the complete decay of short lived radionuclides, long-lived NCA products were separated sequentially from the bulk cadmium by liquid-liquid extraction using di-(2-ethylhexyl)phosphoric acid (HDEHP) dissolved in cyclohexane as organic phase and HCl as aqueous phase. At the optimum condition, 10-2 M HCl and 5 % HDEHP, NCA In along with NCA Sn radionuclides (75 %) were separated from the bulk Cd resulting to high separation factors of 2.7 x 104 (DIn/DCd) and 500 (DSn/DCd), respectively. The NCA In was stripped back completely to the aqueous phase by 6 M HCl leaving NCA Sn in the HDEHP phase with a separation factor (DSn/DIn) of 3.94 x 106. (author)

  3. Caracterização tecnológica de rejeito de minério de ferro Technological characterization of iron ore tailing

    Marcos Antônio Gomes; Carlos Alberto Pereira; Antônio Eduardo Clark Peres

    2011-01-01

    Nesse trabalho, é apresentada a caracterização dos finos, estocados na barragem I como rejeito proveniente do tratamento de minério ferro. Na caracterização das amostras, estão apresentadas análises granulométricas por peneiramento a úmido, análises químicas por espectrometria de plasma e análise mineralógica por difração de raios X. De posse das análises de caracterização, foram executados ensaios tecnológicos, visando à obtenção de concentrado para aplicação na indústria metalúrgica. Foram ...

  4. Action de l'aluminoferrite tétracalcique sur les aspects minéralogique, cinétique et chaleur d'hydratation

    BRIQUET, Philippe

    2011-01-01

    Cette étude bibliographique permet de mieux cerner l'action du C4AF sur les aspects minéralogique, cinétique et chaleur d'hydratation, pour prévenir des réactions physico-chimiques délétères sur ouvrages. L'hydratation du C4AF en présence de gypse a lieu en deux phases. Dans les premières heures d'hydratation, une formation rapide d'ettringite agit comme une barrière passivante causée par un gel amorphe étanche à l'eau. Puis, cette barrière se rompt, entraînant une reprise de l'hydratation av...

  5. Étude des minéraux hydratés à la surface de Mars par les imageurs hyperspectraux OMEGA/MEx et CRISM/MRO

    Carter, John

    2011-01-01

    La planète Mars a connu une période où l'eau liquide était durablement stable. Outre les vestiges morphologiques d'une activité hydrologique en surface, l'interaction chimique de l'eau avec la croûte basaltique s'est traduite par la formation d'argiles et de sels hydratés en surface et en profondeur. Ces minéraux hydratés ont été détectés à la surface de Mars en 2004 grâce à l'instrument OMEGA, l'imageur hyperspectral infrarouge proche embarqué sur la sonde européenne Mars Express. Leur étude...

  6. 济南市闵子骞祠堂东汉墓%Eastern Han Tomb in the Min Ziqian Ancestral Temple in Jinan City

    济南市考古研究所

    2004-01-01

    In 2000, the Jinan Municipal Institute of Archaeology carried out a rescuing excavation to explore a tomb in the Min Ziqian ancestral temple, Jinan City. The grave is built of brick and stone, consists of an anterior, a middle, a back and two side rooms, and has a "凸"-shaped plan. It has been seriously robbed, but still above 60 pottery objects and copper coins are left over from the grave goods. Among them pottery domestic fowls and animals come first in number, and four pictorial stones remain in the tomb. The tomb shape, the features of the objects and those of the pictorial stones suggest that the burial belongs to the late Eastern Han period.

  7. Applications of a saving method with max-min ant system to a vehicle routing problem with time windows and speed limits

    Suphan Sodsoon

    2014-06-01

    Full Text Available This study aims to solve a Vehicle Routing Problem with Time Windows and Speed Limits (VRPTWSL, which has received considerable attention in recent years. The vehicle routing problem with time windows is an extension of the well-known Vehicle Routing Problem (VRP and involves a fleet of vehicles set of from a depot to serve a number of customers at different geographic locations with various demands within specific time and speed limits before returning to the depot eventually. To solve the problem, an efficient Saving Method-Max Min Ant System (Saving-MMAS with Local Search algorithm is applied. Using minimization of the total transportation costs as the objective of the extension VRPTWSL, a mathematic model is constructed. Finally, the Saving-MMAS algorithms indicated the good quality of the method in this problem.

  8. A study of gravity-wave spectra in the troposphere and stratosphere at 5-min to 5-day periods with the Poker Flat MST radar

    Bemra, R. S.; Rastogi, P. K.; Balsley, B. B.

    1986-01-01

    An analysis of frequency spectra at periods of about 5 days to 5 min from two 20-day sets of velocity measurements in the stratosphere and troposphere region obtained with the Poker Flat mesosphere-stratosphere-troposphere (MST) radar during January and June, 1984 is presented. A technique based on median filtering and averaged order statistics for automatic editing, smoothing and spectral analysis of velocity time series contaminated with spurious data points or outliers is outlined. The validity of this technique and its effects on the inferred spectral index was tested through simulation. Spectra obtained with this technique are discussed. The measured spectral indices show variability with season and height, especially across the tropopause. The discussion briefly outlines the need for obtaining better climatologies of velocity spectra and for the refinements of the existing theories to explain their behavior.

  9. Elevated incidence of polyp formation in APC(Min/⁺Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations.

    Antoaneta Belcheva

    Full Text Available Gut microbiota has been linked to a number of human diseases including colon cancer. However, the mechanism through which gut bacteria influence colon cancer development and progression remains unclear. Perturbation of the homeostasis between the host immune system and microbiota leads to inflammation and activation of macrophages which produce large amounts of nitric oxide that acts as a genotoxic effector molecule to suppress bacterial growth. However, nitric oxide also has genotoxic effects to host cells by producing mutations that can predispose to colon cancer development. The major DNA lesions caused by nitric oxide are 8oxoG and deamination of deoxycytosine bases. Cellular glycosylases that belong to the base excision repair pathway have been demonstrated to repair these mutations. Recent evidence suggests that the mismatch repair pathway (MMR might also repair nitric oxide-induced DNA damage. Since deficiency in MMR predisposes to colon cancer, we hypothesized that MMR-deficient colon epithelial cells are incapable of repairing nitric-oxide induced genetic lesions that can promote colon cancer. Indeed, we found that the MMR pathway repairs nitric oxide-induced DNA mutations in cell lines. To test whether nitric oxide promotes colon cancer, we genetically ablated the inducible nitric oxide synthase (iNOS or inhibited iNOS activity in the APC(Min/+Msh2(-/- mouse model of colon cancer. However, despite the fact that nitric oxide production was strongly reduced in the colon using both approaches, colon cancer incidence was not affected. These data show that nitric oxide and iNOS do not promote colon cancer in APC(Min/+Msh2(-/- mice.

  10. Academic Experience of Professor Panzhi-min in Treating Abdominal Masses%潘智敏教授治疗积证的学术经验

    袁国荣

    2011-01-01

    潘智敏教授系第四批全国名老中医药学术经验继承指导老师,博士研究生导师,临证30余年,学验俱丰,其在治疗积证方面积累了丰富的学术经验.潘智敏教授在继承前人积证学说的基础上,结合时代、地域特点和长期的临床经验,拓展了积证的范畴,提出了现代积证的病因病机特点,总结了新五积说,研制了治疗各种积证的基本方:五积方.并运用五积方加减治疗各种积证,取得了较好的临床疗效.%Professor Pan zhi - min is the guidance teacher of the 4th Famous TCM Experts Academic Experience and doctoral Advisor. She has clinical experience over 30 years and is high in academic level. Especially she has rich Academic experience in treating Abdominal Masses. On the base of forearms' theory of Abdominal Masses, Professor Pan zhi - min expanded domain of Abdominal Masses , developed characteristic of pathogeny and pathomechanism of morden Abdominal Masses, summarized'new wuji theory and developed basic prescription in treating all kinds of Abdominal Masses: wuji recepto according to characteristic of times and regions and long - time clinical experience. She has cured all kinds of Abdominal Masses by use of wuji recepto and its clinical curative effect was good.

  11. Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

    Brudvik Kristoffer W

    2011-12-01

    Full Text Available Abstract Background The adenomatous polyposis coli (APC protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and prostaglandin E2 (PGE2 - PI-3 kinase pathways. Recent reports show that PGE2-induced phosphorylation of β-catenin by protein kinase A (PKA increases nuclear translocation indicating two mechanisms of action of PGE2 on β-catenin homeostasis. Findings Treatment of ApcMin/+ mice that spontaneously develop intestinal adenomas with a PKA antagonist (Rp-8-Br-cAMPS selectively targeting only the latter pathway reduced tumor load, but not the number of adenomas. Immunohistochemical characterization of intestines from treated and control animals revealed that expression of β-catenin, β-catenin nuclear translocation and expression of the β-catenin target genes c-Myc and COX-2 were significantly down-regulated upon Rp-8-Br-cAMPS treatment. Parallel experiments in a human colon cancer cell line (HCT116 revealed that Rp-8-Br-cAMPS blocked PGE2-induced β-catenin phosphorylation and c-Myc upregulation. Conclusion Based on our findings we suggest that PGE2 act through PKA to promote β-catenin nuclear translocation and tumor development in ApcMin/+ mice in vivo, indicating that the direct regulatory effect of PKA on β-catenin nuclear translocation is operative in intestinal cancer.

  12. A comparison of intravascular source designs based on the beta particle emitter 114mIn/114In Line source versus stepping source

    Background: Catheter-based intravascular brachytherapy (IVB) sources of the next generation will have to meet high demands in terms of miniaturization, flexibility, safety, reliability, costs and versatility. The radionuclide pair 114mIn/114In (half-life 49.51 days, maximum beta energy 2.0 MeV, average beta energy 0.78 MeV) is an attractive beta emitter for application in such a source. Methods: Since metallic indium is unfit for the manufacture of a brachytherapy source, the feasibility, safety and dosimetric properties of a design concept comprising a linear array of ceramic In2O3 spheres within a thin-walled, superelastic Ni/Ti capsule are investigated. Results: Neutron activation of enriched In2O3 spheres yields a specific activity sufficiently high for the manufacture of a stepping source, keeping treatment times limited to a few minutes. Although 114mIn/114In also emits some gamma radiation, the effective doses received by members of the medical staff are an order of magnitude lower than those received from fluoroscopy. The dose distributions about a 40-mm line source and a 5-mm stepping source (outer diameter 0.36 mm) are calculated using MCNP4C. Dose-volume histograms (DVHs) are calculated for the line source (centered and noncentered) and the stepping source (centered) using the geometry of a human coronary artery. Conclusion: The results show that a centered stepping source with optimized dwell times delivers the most homogenous dose within the target volume

  13. Ultra-large scale synthesis of high electrochemical performance SnO2 quantum dots within 5 min at room temperature following a growth self-termination mechanism

    Highlights: • SnO2 quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl2⋅2H2O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO2 quantum dots own high electrochemical performance. - Abstract: SnO2 quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl2⋅2H2O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO2 quantum dots within 5 min. The formation of SnO2 is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl2⋅2H2O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO2 quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes

  14. 不同浓度 DMSO 对 Min6胰岛细胞活力和ROS 产生的影响%The effects of DMSO on cell viability and reactive oxygen species production in Min6 islet cell

    张红; 张丽; 张燕; 张之

    2015-01-01

    Objective To observe the effects of dimethyl sulfoxide on Min6 islet cell viability and Reactive Oxygen Species Production (ROS).Methods Min6 islet cell was cultured under sterile clean environment condition,then interfered by DMSO of different concentration,Cell Counting Kit-8 was adopted to detect the cell viability,DCFH-DA probe was used to detect the Production of ROS.Results Compared with 0%DMSO group ,Min6 cell viability decreased in group containing DMSO 0.005%,0.0125%,0.05%, 0.125%,0.25%,there was little difference of cell viability between groups containing 0.005%,0.0125%, 0.05%,0.125% DMSO.Cell viability decreased further in 0.25% DMSO group,at the the same time ROS production increased.Conclusion Min6 cell sensitive to DMSO,different concentration of DMSO may have different influence on cell viability and intracellular ROS level.it is suggested that to keep the same con-centration of DMSO in different group or wrong conclusion may be get.%目的:观察不同浓度二甲基亚砜(DMSO)对 Min6胰岛细胞活力和细胞活性氧族(ROS)产生的影响。方法无菌洁净环境下培养 Min6胰岛细胞株,细胞良好生长状态时,分为正常对照组(DMSO 含量为0%)及DMSO 各浓度组,用不同浓度 DMSO(0.005%、0.0125%、0.05%、0.125%、0.25%)干预 Min6胰岛细胞48 h,采用细胞增殖和毒性检测试剂盒(Cell Counting Kit-8,CCK8法)检测细胞活力,采用2′,7′-二氯荧光黄双乙酸盐(DCFH-DA)探针法检测 ROS 的产生水平。结果与正常对照组比较(不含 DMSO),0.005%、0.0125%、0.05%、0.125%,0.25% DMSO 组细胞活力均降低;0.005%、0.0125%、0.05%、0.125% DMSO 组间细胞活力差别不大,0.25%DMSO组细胞活力进一步下降,同时 ROS 产生明显增加。结论Min6细胞对 DMSO 敏感,DMSO 浓度水平对细胞活力、ROS 水平有一定影响,建

  15. "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..." : [luuletused] / Catharina Gripenberg ; tlk. Juta-Tiia Mägi

    Gripenberg, Catharina

    2004-01-01

    Sisu: "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..."; "Tean, et kajad vastavad, aga väga lühidalt. Valad sa välja oma ..." = "Vet att ekon svarar, men i all korthet. Gjuter du ut ditt hjärta ..."; "Kirjasõber, ma otsin välja jääkraabitsa ..." = "Brevvän, jag lagrar upp med fönsterskapare ..."; "Säravselge hommik. Linnupojad trügivad välja kolbast ..." = "Det var en glasklar morgon. Fågelungarna knuffas från skallen ..."; Armastuskiri = Kärleksbrev

  16. Ensemble feature selection using min-max strategy%基于最小最大策略的集成特征选择

    周国静; 李云

    2014-01-01

    特征选择是机器学习和数据挖掘中的一个关键问题,它可以实现数据维度的约减,从而提高学习模型的泛化能力。近年来,为了提高特征选择算法的性能,集成思想被应用到特征选择算法中,即将多个基特征选择器进行集成。本文从提高特征选择算法对大规模数据处理能力的角度出发,提出了一种基于最小最大策略的集成特征选择方法。它主要包括三个步骤:第一,将原始数据根据类别信息划分成多个相对较小的平衡数据子集;第二,在每一个数据子集上进行特征选择,得到多个特征选择结果;第三,对多个特征选择结果依据最小-最大策略进行集成,得出最终的特征选择结果。通过实验对比了该集成策略与其它三种集成策略对分类准确率的影响,结果表明最小最大集成策略在大部分情况下能够获得较好的性能,且基于最小最大策略的集成特征选择可以有效处理大规模数据。%Feature selection is one of the key problems in machine learning and data mining.It involves identifying a subset of the most useful features that produces compatible results as the original entire set of features.It can reduce the dimensionality of original data,speed up the learning process and build comprehensible learning models with good generalization performance.Nowadays,ensemble idea has been used to improve the performance of feature selection by integrating multiple base feature selection models into an ensemble one.It turned out to be effective in dealing with high dimensionality small sample size problem especially for robust biomarker identification.In this paper,we aim to improve the efficiency of feature selection in dealing with large scale problems.In order to deal with such problems,ensemble feature selection using min-max strategy is proposed.The method consists of three main steps:firstly,the original data is decomposed into a

  17. Model of the impact of parameters controlling replenishment in the bs (min-max continuous review system on the actual inventory availibility

    Stanisław Krzyżaniak

    2015-09-01

    Full Text Available Background: Due to random changes in demand, inventory management is still - despite the development of alternative goods flow management concepts - an important issue both in terms of costs of maintenance and replenishment as well as the level of service measured by inventory availability levels. There are a number of replenishment systems to be used in such conditions, but they are most often formed on the basis of two basic ones: a system based on the reorder point and based on periodic inspection.  This paper refers to the former system, the BS system (min-max, in which an order is placed after reaching inventory level B (information level, reorder point for a quantity allowing to reach level S. This system is very often used in business practice. Observations conducted under realistic conditions indicate the need to improve the classical models describing the system.  This results, among other things, from the fact that the actual level of available inventory at the start of the replenishment cycle may be significantly lower than level B, resulting in lower than expected levels of customer service. Taking account of this phenomenon through model determination of the cumulative distribution function for the observed difference makes it possible to select the correct parameters to control the replenishment system in question and - therefore - to achieve the expected economic effects. Methods: The object of the study is to create a mathematical model allowing the determination of the required inventory level B taking into account the difference D between this level and the actual level of inventory at the start of the replenishment cycle.  To determine the effect of various factors such as demand distribution parameters in the adopted unit of time and the difference between level S (max and B (min, a dedicated tool (simulator in EXCEL spreadsheet for determining the distribution of frequency of value D has been developed.  Then a

  18. Flotação direta de minério de ferro com oleato de sódio Iron ore direct flotation with sodium oleate

    Gilmara Mendonça Lopes

    2009-09-01

    Full Text Available O objetivo desse trabalho foi estudar a possibilidade de concentração de minério de ferro por flotação direta, usando oleato de sódio como coletor dos minerais de ferro e o metassilicato de sódio como depressor da ganga silicosa. Após a caracterização das amostras minerais e do minério, foram feitos estudos fundamentais, que englobaram a determinação do potencial zeta dos minerais hematita e quartzo, cujos valores de PIE ocorreram em pH 7,5 e 1,8, respectivamente. Os ensaios de microflotação, em tubo de Hallimond modificado, determinaram as condições de maior flotabilidade da hematita, 50 mg/L de oleato de sódio em pH 7, e do quartzo, 70 mg/L de oleato de sódio em pH 9. Os ensaios de microflotação, ainda mostraram que o metassilicato de sódio foi mais efetivo na depressão da hematita que na depressão do quartzo. Os ensaios de flotação em bancada confirmaram esse comportamento, ou seja, o metassilicato de sódio não propicia separação seletiva entre a hematita e o quartzo durante a flotação. O melhor concentrado fornecido pela flotação direta da amostra de minério de ferro, cujos teores de Fe e SiO2 eram, respectivamente, de 35,34 e 48,02%, foi obtido usando-se dosagens de 600 g/t de metassilicato de sódio e 1200 g/t de oleato de sódio: recuperação metalúrgica de Fe de 88%, teor de Fe de 58,1% e teor de SiO2 de 14,4%.The goal of this paper was to study the possibility of concentrating iron ore by direct flotation with sodium oleate as a collector of iron minerals and a water glass as a depressant of the siliceous gangue. Following characterization studies of minerals and iron ore samples, fundamental studies with mineral samples of hematite and quartz were performed: zeta potential determinations and microflotation tests in a modified Hallimond tube. The isoelectric points of hematite and quartz were determined at pH = 7.5 and 1.8, respectively. The highest hematite floatability was achieved at 50 mg

  19. Coordinated Analyses of Antarctic Sediments as Mars Analog Materials Using Reflectance Spectroscopy and Current Flight-Like Instruments for CheMin, SAM and MOMA

    Bishop, Janice L.; Franz, Heather B.; Goetz, Walter; Blake, David F.; Freissinet, Caroline; Steininger, Harald; Goesmann, Fred; Brinckerhoff, William B.; Getty, Stephanie; Pinnick, Veronica T.; Mahaffy, Paul R.; Dyar, M. Darby

    2013-01-01

    Coordinated analyses of mineralogy and chemistry of sediments from the Antarctic Dry Valleys illustrate how data obtained using flight-ready technology of current NASA and ESA missions can be combined for greater understanding of the samples. Mineralogy was measured by X-ray diffraction (XRD) and visible/ near-infrared (VNIR) reflectance spectroscopy. Chemical analyses utilized a quadrupole mass spectrometer (QMS) to perform pyrolysis-evolved gas analysis (EGA) and gas chromatography-mass spectrometry (GC/MS) both with and without derivatization, as well as laser desorption-mass spectrometry (LD/MS) techniques. These analyses are designed to demonstrate some of the capabilities of near-term landed Mars missions, to provide ground truthing of VNIR reflectance data acquired from orbit by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) on MRO and to provide detection limits for surface- operated instruments: the Chemistry and Mineralogy (CheMin) and Sample Analysis at Mars (SAM) instrument suites onboard Mars Science Laboratory (MSL) and the Mars Organic Molecule Analyzer (MOMA) onboard ExoMars-2018. The new data from this study are compared with previous analyses of the sediments performed with other techniques. Tremolite was found in the oxic region samples for the first time using the CheMin-like XRD instrument. The NIR spectral features of tremolite are consistent with those observed in these samples. Although the tremolite bands are weak in spectra of these samples, spectral features near 2.32 and 2.39 micrometers could be detected by CRISM if tremolite is present on the martian surface. Allophane was found to be a good match to weak NIR features at 1.37-1.41, 1.92, and 2.19 micrometers in spectra of the oxic region sediments and is a common component of immature volcanic soils. Biogenic methane was found to be associated with calcite in the oxic region samples by the SAM/EGA instrument and a phosphoric acid derivative was found in the anoxic

  20. Inhibition of intestinal adenoma formation in APC(Min/+ mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta.

    Hui-Ping Liu

    Full Text Available BACKGROUND: Mutation of tumor suppressor gene, adenomatous polyposis coli (APC, is the primary molecular event in the development of most intestinal carcinomas. Animal model with APC gene mutation is an effective tool for study of preventive approaches against intestinal carcinomas. We aimed to evaluate the effect of Riccardin D, a macrocyclic bisbibenzyl compound, as a chemopreventive agent against intestinal adenoma formation in APC(Min/+ mice. METHODS: APC(Min/+ mice were given Riccardin D by p.o. gavage for 7 weeks. Mice were sacrificed, and the number, size and histopathology of intestinal polyps were examined under a microscope. We performed immunohistochemical staining, western blotting, reverse transcriptase-polymerase chain reaction (RT-PCR and enzyme-linked immunosorbent assay (ELISA in intestinal polyps to investigate the mechanism of chemopreventive effect of Riccardin D. RESULTS: Riccardin D treatment resulted in a significant inhibition of intestinal adenoma formation, showing a reduction of polyp number by 41.7%, 31.1% and 44.4%, respectively, in proximal, middle and distal portions of small intestine. The activity of Riccardin D against polyp formation was more profound in colon, wherein Riccardin D decreased polyp number by 79.3%. Size distribution analysis revealed a significant reduction in large-size polyps (2-3 mm by 40.0%, 42.5% and 33.3%, respectively, in proximal, middle and distal portions of small intestine, and 77.8% in colon. Histopathological analysis of the intestinal polyps revealed mostly hyperplastic morphology without obvious dysplasia in Riccardin D-treated mice. Molecular analyses of the polyps suggested that the inhibitory effect of Riccardin D on intestinal adenoma formation was associated with its abilities of reduction in cell proliferation, induction of apoptosis, antiangiogenesis, inhibition of the Wnt signaling pathway and suppression of inflammatory mediators in polyps. CONCLUSIONS: Our results

  1. Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: design of the MInT study

    Taylor Barry J

    2010-05-01

    Full Text Available Abstract Background Because parental recognition of overweight in young children is poor, we need to determine how best to inform parents that their child is overweight in a way that enhances their acceptance and supports motivation for positive change. This study will assess 1 whether weight feedback delivered using motivational interviewing increases parental acceptance of their child's weight status and enhances motivation for behaviour change, and 2 whether a family-based individualised lifestyle intervention, delivered primarily by a MInT mentor with limited support from "expert" consultants in psychology, nutrition and physical activity, can improve weight outcomes after 12 and 24 months in young overweight children, compared with usual care. Methods/Design 1500 children aged 4-8 years will be screened for overweight (height, weight, waist, blood pressure, body composition. Parents will complete questionnaires on feeding practices, physical activity, diet, parenting, motivation for healthy lifestyles, and demographics. Parents of children classified as overweight (BMI ≥ CDC 85th will receive feedback about the results using Motivational interviewing or Usual care. Parental responses to feedback will be assessed two weeks later and participants will be invited into the intervention. Additional baseline measurements (accelerometry, diet, quality of life, child behaviour will be collected and families will be randomised to Tailored package or Usual care. Parents in the Usual care condition will meet once with an advisor who will offer general advice regarding healthy eating and activity. Parents in the Tailored package condition will attend a single session with an "expert team" (MInT mentor, dietitian, physical activity advisor, clinical psychologist to identify current challenges for the family, develop tailored goals for change, and plan behavioural strategies that best suit each family. The mentor will continue to provide support to the

  2. A max-to-min technique for making projections of NDVI change in semi-arid Africa for food security early warning

    Brown, M. E.; Funk, C. C.

    2005-12-01

    Climatic hazards such as droughts and floods often result in a decline in food production in economically vulnerable pre-industrial economies such as those in Africa. Early warning systems (EWS) have been developed to identify slow onset disasters such famine and epidemic disease that may result from hazardous environmental conditions. These conditions often precede food crises by many months, thus effective monitoring via satellite and in situ observations can allow for successful mitigation activities. Accurate forecasts of NDVI could increase monitoring lead times and allow for effective institutional planning of intervention, making early warning earlier. This paper presents a simple empirical max-to-min model for making 1 to 4 month NDVI projections. These statistical projections are based on parameterized satellite rainfall estimates (RFE) and relative humidity demand (RHD). A heuristic example in central Zimbabwe introduces the RFE growth and RHD loss terms. A quasi-global, one month ahead, 1 degree study then demonstrates reasonable accuracies in many semi-arid regions. In Africa, a 0.1 degree cross-validated skill assessment quantifies the technique's applicability at 1 to 4 month forecast intervals. These results suggest that useful projections can be made over many semi-arid, food insecure regions of Africa, with plausible extensions to drought prone areas of Asia, Australia and South America.

  3. MIN 14C UBT: A combination of gastric basal transit and 14C-urea breath test for the detection of helicobacter pylori infection in human beings

    The purpose of this work is to demonstrate that the 14C-urea breath test (UBT) performed at different times combined with the study of the gastric basal transit, which evaluates the intragastric displacement of a labeled solution under fasting conditions, has the advantage of being representative of the whole stomach surface and constitutes a non-aggressive test for the detection of H. pylori. This test, which has been called MIN 14C UBT, is a modification of the conventional 14C UBT in which low volumes of a solution of 14C-urea together with 99mTc-sulfur colloid are administered. The 99mTc-sulfur colloid is not absorbed in the gastrointestinal tract and has the great advantage of allowing the 'visualization' of the transit of the 14C-urea within the gastrointestinal tract. This modification allows the simultaneous determination of the production of the 14CO2 and the place where this process occurs. The results show that there is a good correlation between the images obtained and the breath samples collected. We found that this test has a sensitivity of 98% and a specificity of 96% for H. pylori detection

  4. Estimated preejection period (PEP) based on the detection of the R-wave and dZ/dt-min peaks in ECG and ICG

    van Lien, René; Schutte, Nienke M.; Meijer, Jan H.; de Geus, Eco J. C.

    2013-04-01

    The validity of estimating the PEP from a fixed value for the Q-wave onset to the R-wave peak (QR) interval and from the R-wave peak to the dZ/dt-min peak (ISTI) interval is evaluated. Ninety-one subjects participated in a laboratory experiment in which a variety of physical and mental stressors were presented and 31 further subjects participated in a sequence of structured ambulatory activities in which large variation in posture and physical activity was induced. PEP, QR interval, and ISTI were scored. Across the diverse laboratory and ambulatory conditions the QR interval could be approximated by a fixed interval of 40 ms but 95% confidence intervals were large (25 to 54 ms). Multilevel analysis showed that 79% to 81% of the within and between-subject variation in the RB interval could be predicted by the ISTI. However, the optimal intercept and slope values varied significantly across subjects and study setting. Bland-Altman plots revealed a large discrepancy between the estimated PEP and the actual PEP based on the Q-wave onset and B-point. It is concluded that the estimated PEP can be a useful tool but cannot replace the actual PEP to index cardiac sympathetic control.

  5. ZHAO Xue-min Folk Medicine Achievements%赵学敏在民间医药学方面的成就

    赵军

    2011-01-01

    ZHAO Xue-min is Qing Dynasty renowned medicine scientist, in its extant work Native Chinese Plants Appropriated lost articles and String Elegant has preserved the massive folk medicine precious content, the collection, the reorganization, summarized the massive folk medicine experience, the massive folk single proven prescription, specially walked Fang Yi the prevention disease's experience, this studied the folk medicine for us the development, has provided the very valuable material.%赵学敏是清代著名的医药学家,在其现存的著作《本草纲目拾遗》和《串雅》中保存了大量民间医药学的宝贵内容,收集、整理、总结了大量民间医药学经验,大量的民间单验方,特别是走方医的防治疾病的经验,这为我们研究民间医药学的发展,提供了十分可贵的资料.

  6. Fluxo de material fragmentado em passagem de minério nas minas subterrâneas: a prática corrente

    José Margarida da Silva

    2006-09-01

    Full Text Available Esse trabalho é parte de pesquisa realizada para preparação de tese de doutorado e apresenta estudo do fluxo por gravidade de material fragmentado em mineração subterrânea. É descrita a prática corrente em minas brasileiras e estrangeiras, enfocando os índices de acidentes, as ações preventivas e corretivas nas operações que utilizam o fluxo por gravidade de minério desmontado em passagens, presentes em diversos métodos de lavra, como na lavra por subníveis, por corte e enchimento e nos métodos que utilizam o abatimento controlado do teto da escavação subterrânea.This article shows some results of a doctorate thesis about the gravity flow of bulk material in an underground mine. It describes the practices in Brazilian mines and in other countries, focusing on accident data, preventive and corrective actions, in mining operations that use gravity flow to transport fragmented material from the excavation of ore passes in several mining operations, such as in underground mining using cut and fill methods and caving methods.

  7. 潘智敏教授理瘀的学术经验%Academic Experience of Professor PAN Zhi-min on Curing Stasis

    袁国荣; 潘智敏

    2011-01-01

    Professor PAN Zhi - min is the guidance teacher of the 4th Famous TCM Expert's Academic Experience and doctoral Advisor. She is a student of Professor YANG Ji - sun, the Famous TCM Expert and has a great deal of experience on treating stasis. On the basis of forearms'theory of stasis, professor pan summarized ten types of stasis and stated characteristic of aged disease with stasis. Finally she brought forward suggestions and experienced drugs on curing stasis.%潘智敏教授系第四批全国名老中医药学术经验继承指导老师,博士生导师,得著名中医临床学家杨继荪教授的真传,临证30余年,学验俱丰,其对瘀证的研究,造诣较深.潘智敏教授在继承前人瘀证学说的基础上,总结了瘀证10型,提出了理瘀的对策和经验用药.

  8. Preliminary Inquiry on the Modern Culture Value of the Southern Min Pat Chest Dance%闽南拍胸舞现代文化价值初探

    吴红叶

    2012-01-01

    拍胸舞是流行于福建南部沿海地区的民间舞蹈,其风格独特、色彩浓郁、自娱性强。在时代的发展及历史沉淀中,拍胸舞的表演形态与舞蹈功能都有了不同程度的丰富与改变。作为闽南代表性民间舞蹈,拍胸舞有着文化的传承与保护价值。同时,作为一项旅游文化资源,其对外文化交流价值也不容忽视。%"Pat Chest Dance" is a kind of folk dance which is popular in the coastal areas of Southern Fujian, it has unique style and strong entertainment. With the development of the times, the form of the chest percussion dance and performing function have different levels of wealth and change. As the Southern Min the most representa- tive folk dance, pat chest dance cultural heritage and conservation value. As a tourism and cultural resources, its cultural exchanges with foreign value can not be ignored.

  9. Localized field-aligned currents and 4-min TEC and ground magnetic oscillations during the 2015 eruption of Chile's Calbuco volcano

    Aoyama, Tadashi; Iyemori, Toshihiko; Nakanishi, Kunihito; Nishioka, Michi; Rosales, Domingo; Veliz, Oscar; Safor, Erick Vidal

    2016-08-01

    The Calbuco volcano in southern Chile erupted on April 22, 2015. About 2 h after the first eruption, a Swarm satellite passed above the volcano and observed enhancement of small-amplitude (~0.5 nT) magnetic fluctuations with wave-packet structure which extends 15° in latitude. Similar wave packet is seen at the geomagnetic conjugate point of the volcano. Just after the eruption, geomagnetic fluctuations with the spectral peaks around the vertical acoustic resonance periods, 215 and 260 s, were also observed at Huancayo Geomagnetic Observatory located on the magnetic equator. Besides these observations, around 4-min, i.e., 175, 205 and 260 s, oscillations of total electron content (TEC) were observed at global positioning system stations near the volcano. The horizontal propagation velocity and the spatial scale of the TEC oscillation are estimated to be 720 m/s and 1600 km, respectively. These observations strongly suggest that the atmospheric waves induced by explosive volcanic eruption generate TEC variation and electric currents. The Swarm observation may be explained as a manifestation of their magnetic effects observed in the topside ionosphere.

  10. Estimated preejection period (PEP) based on the detection of the R-wave and dZ/dt-min peaks in ECG and ICG

    The validity of estimating the PEP from a fixed value for the Q-wave onset to the R-wave peak (QR) interval and from the R-wave peak to the dZ/dt-min peak (ISTI) interval is evaluated. Ninety-one subjects participated in a laboratory experiment in which a variety of physical and mental stressors were presented and 31 further subjects participated in a sequence of structured ambulatory activities in which large variation in posture and physical activity was induced. PEP, QR interval, and ISTI were scored. Across the diverse laboratory and ambulatory conditions the QR interval could be approximated by a fixed interval of 40 ms but 95% confidence intervals were large (25 to 54 ms). Multilevel analysis showed that 79% to 81% of the within and between-subject variation in the RB interval could be predicted by the ISTI. However, the optimal intercept and slope values varied significantly across subjects and study setting. Bland-Altman plots revealed a large discrepancy between the estimated PEP and the actual PEP based on the Q-wave onset and B-point. It is concluded that the estimated PEP can be a useful tool but cannot replace the actual PEP to index cardiac sympathetic control.

  11. 肝脏脱细胞支架与MIN6细胞三维共培养移植治疗Ⅰ型糖尿病实验研究%Three dimensional co-culture of MIN6 cells and liver-derived perfusion-decellularized bioscaffold for potential clinical practice

    朱沙俊; 王雷

    2015-01-01

    目的:通过体外制备小鼠肝脏脱细胞支架并种植MIN6细胞,观测其定植生长并检测其功效发挥,为体外构建胰岛素分泌器官提供理论基础。方法:灌注法制备全肝脏脱细胞支架,将小鼠MIN6细胞种植入支架中于三维培养体系中培养,通过苏木精-伊红染色、胰岛素免疫组化分析及荧光定量聚合酶链反应检测其功效。检测MIN6细胞功能基因Insulin表达。将种植MIN6细胞的肝脏脱细胞支架移植入糖尿病小鼠体内,监测其功能发挥并初步评估其疗效。结果:体外成功制备肝脏脱细胞支架,在保留其原有脉管网络基础上,未见组织残留。HE染色显示肝脏脱细胞支架内没有细胞核染,且脉管结构保存完整。扫描电镜未见细胞结构,支架保存完整胶原纤维形态。MIN6细胞在脱细胞支架中三维培养后,检测胰岛素基因表达水平,结果和平面培养相比较,差异具有统计学意义(P<0.05)。将种植MIN6细胞的肝脏脱细胞支架移植入糖尿病小鼠体内能够较好的发挥降血糖作用。结论:通过将MIN6细胞种植入肝脏脱细胞支架并三维培养,可构建体外胰岛素分泌体系。%Objective:To observe the growth and function of primary mouse islets in the liver decellularized bioscaf-fold (LDB). At the same time, a new method of tissue engineering for treatment of diabetes was explored. Methods: The whole mouse liver was perfused by using detergent through hepatic portal vein in a continuous way and the whole liver de-cellularized bioscaffold was manufactured with the complete structure. The MIN6 cells cultured in the 3D bioscaffold. Then the hematoxylin-eosin (HE) staining, insulin immunohistochemical analysis and fluorescence quantitative polymerase chain reaction (PCR) were performed. qRT-PCR was conducted for the functional gene of INS1 and INS2 to further illuminate its function. The function of the recellularized

  12. Caracterização de uma tipologia de minério de manganês do Brasil Characterization of a Brazilian manganese ore typology

    Érica Linhares Reis

    2010-09-01

    Full Text Available Visando a melhorias no beneficiamento e no processo de fabricação de ferroligas de manganês, foi realizada a caracterização de uma tipologia predominante de minério de manganês, de ocorrência na região de Carajás, PA, BR. Obteve-se uma amostra representativa da tipologia e foram realizadas análise granulométrica por peneiramento e análise química, por ICP-AES. Foram identificadas por difratometria de raios X as fases minerais majoritárias. Um estudo termogravimétrico foi desenvolvido para verificar a estabilidade térmica, ao ar, das fases minerais majoritárias. Observou-se que 19,3% da amostra encontram-se abaixo de 6,3mm. O teor de manganês no minério foi de 52,63% em peso, com 1,92% de sílica, 0,17% de fósforo e 3,13% de ferro. Foram identificados, na amostra, os óxidos de manganês criptomelana, todorokita e pirolusita, com goethita, quartzo, gibbisita e caolinita compondo a ganga. Para a amostra estudada, observou-se a decomposição térmica dos óxidos criptomelana e pirolusita, em torno de 600ºC, ao ar. Em torno de 950ºC, teve início a transformação de Mn2O3 em Mn3O4.In order to improve manganese-iron alloy production processes, an important Brazilian manganese ore typology, placed in Carajás, PA, was characterized. A representative sample was obtained from mine. The particle size determination was performed by screening, followed by chemical analysis using plasma spectrometry (ICP-AES. The physical properties studied included density, surface area and porosity measurements (BET. The mineral constituents was identified and quantified by X-ray diffraction. A termogravimetrical study was done in order to verify the thermal stability of major mineral constituents in the air. It was observed that 19.3% of studied typology was below 6.3mm. The manganese, silica and phosphorus contents were 52.63%, 1.92% and 0.17%, respectively. The oxides identified were cryptomelane, todorokite and pyrolusite. The other

  13. Caracterização tecnológica de rejeito de minério de ferro Technological characterization of iron ore tailing

    Marcos Antônio Gomes

    2011-06-01

    Full Text Available Nesse trabalho, é apresentada a caracterização dos finos, estocados na barragem I como rejeito proveniente do tratamento de minério ferro. Na caracterização das amostras, estão apresentadas análises granulométricas por peneiramento a úmido, análises químicas por espectrometria de plasma e análise mineralógica por difração de raios X. De posse das análises de caracterização, foram executados ensaios tecnológicos, visando à obtenção de concentrado para aplicação na indústria metalúrgica. Foram avaliadas duas rotas de concentração em escala de bancada: uma (rota I constando de classificação (0,15mm, separação magnética (-1,0+0,15mm, deslamagem e flotação (-0,15mm e outra (rota II constando de separação magnética (-1,0mm total. De acordo com a distribuição granulométrica dos finos do minério de ferro, 8,21% das partículas encontram-se retidas em 0,150mm e 58,81% abaixo de 0,045mm. A amostra, conforme Tabela 1, apresenta teores médios (calculado de 48,08% de Fe, 20,58% de SiO2, 3,16% de Al2O3. Os minerais portadores de ferro identificados foram hematita, martita, magnetita e goethita e os minerais de ganga foram quartzo, gibbisita e caolinita. A melhor opção de concentração estudada consistiu na utilização de circuito de concentração somente por separação magnética, rota II. A recuperação em massa e metalúrgica foram, respectivamente, 68,00% e 90,81%, apresentando um concentrado com 67,54% de Fe, 1,50% de SiO2 e 0,49% de Al2O3, atendendo a especificação do produto comercializado pela empresa.This paper addresses the characterization of fines stocked in a pond as tailings from an iron ore concentrator. The characterization consisted of size analyses by wet screening, chemical analyses by ICP, and mineralogical analyses by X-ray diffraction. The next stage consisted of technological tests. Two concentration routes were evaluated at bench scale: the first (route I consisting of classification

  14. Mineralogy, provenance, and diagenesis of a potassic basaltic sandstone on Mars: CheMin X-ray diffraction of the Windjana sample (Kimberley area, Gale Crater)

    Treiman, Allan H.; Bish, David L.; Vaniman, David T.; Chipera, Steve J.; Blake, David F.; Ming, Doug W.; Morris, Richard V.; Bristow, Thomas F.; Morrison, Shaunna M.; Baker, Michael B.; Rampe, Elizabeth B.; Downs, Robert T.; Filiberto, Justin; Glazner, Allen F.; Gellert, Ralf; Thompson, Lucy M.; Schmidt, Mariek E.; Le Deit, Laetitia; Wiens, Roger C.; McAdam, Amy C.; Achilles, Cherie N.; Edgett, Kenneth S.; Farmer, Jack D.; Fendrich, Kim V.; Grotzinger, John P.; Gupta, Sanjeev; Morookian, John Michael; Newcombe, Megan E.; Rice, Melissa S.; Spray, John G.; Stolper, Edward M.; Sumner, Dawn Y.; Vasavada, Ashwin R.; Yen, Albert S.

    2016-01-01

    The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations—like ferrihydrite. The Windjana sample shows little alteration and was likely cemented by its magnetite and ferrihydrite. From ChemCam Laser-Induced Breakdown Spectrometer (LIBS) chemical analyses, Windjana is representative of the Dillinger and Mount Remarkable members of the Kimberley formation. LIBS data suggest that the Kimberley sediments include at least three chemical components. The most K-rich targets have 5.6% K2O, ~1.8 times that of Windjana, implying a sediment component with >40% sanidine, e.g., a trachyte. A second component is rich in mafic minerals, with little feldspar (like a shergottite). A third component is richer in plagioclase and in Na2O, and is likely to be basaltic. The K-rich sediment component is consistent with APXS and ChemCam observations of K-rich rocks elsewhere in Gale Crater. The source of this sediment component was likely volcanic. The presence of sediment from many igneous sources, in concert with Curiosity's identifications of other igneous materials (e.g., mugearite), implies that the northern rim of Gale Crater exposes a diverse igneous complex, at least as diverse as that found in similar-age terranes on Earth.

  15. 具有寿命估算的最大-最小蚂蚁系统%Improved max-min ant system with lifetime estimation

    姚金涛; 祝胜林; 孔宇彦

    2011-01-01

    提出了一种具有寿命估算的最大-最小蚂蚁系统,该算法对进化种群数进行宏观调控的同时,用个体寿命限制个体的生存期,利用蚂蚁能估算自己所剩寿命的能力,实现其突变性的大风险搜索行为,从而扩大搜索范围,即主动性增加蚁群多样性,使蚁群逃离局部最优,并为实现蚁群的快速收敛提供可能.通过对TSP问题的仿真实验结果表明,该方法能够有效防止早熟收敛,较好地平衡局部搜索和全局搜索的收敛性能.%This paper proposes a variant of ACO called Max-Min Ant System with Lifetime Estimation (MMAS_LE). MMASLE uses both macroscopical control and microcosmic control based on lifetime estimating of ants to realize mutation-al and risky search behavior,which can broaden the search space,break local convergence and speed the global convergence by increasing the population diversity actively.The simulation results on TSP problem show that MMASLE can efficiently avoid premature convergence and well balance the exploration and exploitation.

  16. Modulation of pancreatic MIN6 insulin secretion and proliferation and extrapancreatic glucose absorption with Achillea santolina, Eryngium creticum and Pistacia atlantica extracts: in vitro evaluation

    Lara Majdalawi

    2012-06-01

    Full Text Available Objective: The present in vitro studies aimed to investigate the pancreatic and extrapancreatic effects of crude aqueous extracts (AE of Achillea santolina L, Eryngium creticum Lam, and Pistacia atlantica Desf utilized in Jordan diabetes ethnomedicine. Methods: Bioassays of β-cell proliferation and insulin secretion as well as glucose diffusion as possible modes of action were recruited. Results: Similar to L-alanine insulinotropic efficacy in MIN6 β-cell, glucose-stimulated Ca2+ regulated- insulin secretion was potentiated by AEs of E.creticum (0.01 mg/ml and P.atlantica (0.01, 0.1 and 0.5 mg/ml. A.santolina AE, however, was found ineffective. Comparable to glucagon-like peptid-1-enhanced β-cell proliferation in 2-day treatment wells, a dose dependent augmentation of bromodeoxyuridine incorporation was obtained with the A.santolina AE (0.05-1 mg/ml, and E.creticum AE (0.1, 0.5 and 1 mg/ml. P.atlantica concentrations lacked pancreatic proliferative capacity. While A.santolina and E.creticum AEs proved inactive, P.atlantica inhibited dose dependently overnight glucose movement in vitro, as effectively as guar gum diffusional hindrance in a simple glucose dialysis model. Conclusion: Current findings signify the in vitro diverse therapeutic antidiabetes properties of the selected medicinal plants. Future directives may assess the use of A.santolina, E.creticum and P.atlantica as new potential sources of functional foods or nutraceuticals or active leads into diabetes type 2 pharmacotherapy. [J Exp Integr Med 2012; 2(3.000: 245-254

  17. Análise do efeito da granulometria da sílica na flotação convencional reversa de minério de ferro

    William Ricardo de Carvalho

    2005-09-01

    Full Text Available Foram executados ensaios de flotação convencional reversa de minério de ferro em uma etapa de desbaste (rougher. Os ensaios foram conduzidos para três diferentes distribuições granulométricas da sílica (abaixo de 75µm, global e acima de 75µm, variando a dosagem de coletor (50 e 70g/t, a percentagem de sólidos em polpa (40 e 50% e a percentagem de sílica contaminante (20 e 30%, resultando em um total de 24 ensaios. A distribuição grosseira de sílica apresentou menores resultados de rejeição de sílica, o que leva a uma possível utilização de apenas a distribuição de granulometria fina no processo com maiores valores de recuperação, quando comparadas com as demais distribuições.Tests on the reverse froth flotation of rougher-stage iron ore were executed. Such tests were made for three different distributions of silica particle size (below 75 µm, global and above 75 µm. Collector dosage (50 and 70g/t, pulp density (40 and 50% and the silica content (20 and 30% were modified, resulting in twenty-four tests. Distribution of a coarser silica particle size presented lower results of silica rejection. In comparison to other silica particle sizes, silica rejection is increased with the utilization of finer silica particle size distribution in the process

  18. Mineralogy, provenance, and diagenesis of a potassic basaltic sandstone on Mars: CheMin X‐ray diffraction of the Windjana sample (Kimberley area, Gale Crater)

    Bish, David L.; Vaniman, David T.; Chipera, Steve J.; Blake, David F.; Ming, Doug W.; Morris, Richard V.; Bristow, Thomas F.; Morrison, Shaunna M.; Baker, Michael B.; Rampe, Elizabeth B.; Downs, Robert T.; Filiberto, Justin; Glazner, Allen F.; Gellert, Ralf; Thompson, Lucy M.; Schmidt, Mariek E.; Le Deit, Laetitia; Wiens, Roger C.; McAdam, Amy C.; Achilles, Cherie N.; Edgett, Kenneth S.; Farmer, Jack D.; Fendrich, Kim V.; Grotzinger, John P.; Gupta, Sanjeev; Morookian, John Michael; Newcombe, Megan E.; Rice, Melissa S.; Spray, John G.; Stolper, Edward M.; Sumner, Dawn Y.; Vasavada, Ashwin R.; Yen, Albert S.

    2016-01-01

    Abstract The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X‐ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X‐ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations—like ferrihydrite. The Windjana sample shows little alteration and was likely cemented by its magnetite and ferrihydrite. From ChemCam Laser‐Induced Breakdown Spectrometer (LIBS) chemical analyses, Windjana is representative of the Dillinger and Mount Remarkable members of the Kimberley formation. LIBS data suggest that the Kimberley sediments include at least three chemical components. The most K‐rich targets have 5.6% K2O, ~1.8 times that of Windjana, implying a sediment component with >40% sanidine, e.g., a trachyte. A second component is rich in mafic minerals, with little feldspar (like a shergottite). A third component is richer in plagioclase and in Na2O, and is likely to be basaltic. The K‐rich sediment component is consistent with APXS and ChemCam observations of K‐rich rocks elsewhere in Gale Crater. The source of this sediment component was likely volcanic. The presence of sediment from many igneous sources, in concert with Curiosity's identifications of other igneous materials (e.g., mugearite), implies that the northern rim of Gale Crater exposes a diverse igneous complex, at least as diverse as that found in similar‐age terranes on Earth. PMID:27134806

  19. Beat Tracking Based on Max-Min Distance Means%基于最大最小距离法的节拍跟踪

    李锵; 何凝; 关欣

    2015-01-01

    将端点检测与聚类算法结合,提出一种基于最大最小距离法的节拍跟踪算法.首先,将音乐信号分解成多个频率互不重叠的子带进行频谱分析,分别利用半波整流,求和得到最终的端点强度曲线.其后,根据能量谱找到起始节拍点.最后,根据最大最小距离法并利用音乐速度与节拍的关系,对端点强度曲线峰值进行有效聚类,识别出节拍点.实验结果表明,该算法识别节拍点准确有效,4评估指标 P-score、Cemgil、CMLc 和 AMLt 分别达到57.355,10、38.705,37、17.152,40和47.259,12,与其他算法相比综合性能较好.%In this paper,combining onset detection and clustering algorithm,a novelbeat tracking algorithm based on max-min distance(MMD) means was proposed. First,the spectrum of music signal was decomposed into several non-overlapping sub-bands. Second,by utilizing the half-wave rectifier on these sub-bands respectively,the final onset strength curve was found. Then,the first beat was discovered based on the energy spectrum of the starting point. Finally,based on MMDmeans,the beats of the music signal were identified according to the relationship between music tempo and beat,together with effective clustering of curve peaks of onset strength. Experimental re-sults proved that the proposed algorithm can track beats accurately. The four evaluation indicators of the algorithm P-score,Cemgil,CMLc and AMLt,reached 57.355,10,38.705,37,17.152,40 and 47.259,12,respectively. Com-pared with other algorithms,the proposed algorithm possesses better comprehensive performance.

  20. Association between pretreatment retention rate of indocyanine green 15 min after administration and life prognosis in patients with HCC treated by proton beam therapy

    Purpose: The Child-Pugh score is often used to judge the outcome of radiotherapy for hepatocellular carcinoma (HCC). The retention rate of indocyanine green 15 min after administration (ICG R15) can also be used to predict prognosis after liver resection. We evaluated the utility of ICG R15 for prediction of outcomes after proton beam therapy (PBT) for HCC. Methods and materials: A retrospective evaluation was performed in 250 patients who received PBT between 2002 and 2007. The patients (178 males and 72 females) had a median age of 71 years (range: 43–88). Child-Pugh categories were A (score 5–6), B (7–9), and C (10–15) in 197, 51, and 2 patients, respectively. ICG scores were 0–<10, 10–<20, 20–<30, 30–<40 and ⩾40 in 27, 99, 59, 28 and 37 patients, respectively; including 26, 92, 45, 16 and 18 Child-Pugh A patients and 1, 8, 14, 11, and 17 Child-Pugh B patients, respectively. Survival times from the start of PBT were compared between Child-Pugh A and B patients, and among each ICG group. Results: The median survival times were 61 months (95% CI: 50–72 months) in all patients, and 64 and 20 months in Child-Pugh A and B patients, respectively (p = 0.001), The 3-year survival rates were 72%, 72%, 75%, 63%, and 26% in patients with ICG scores of 0–<10, 10–<20, 20–<30, 30–<40, and ⩾40 (p = 0.001); 70%, 75%, 77%, 65%, and 38% in these respective groups in Child-Pugh A patients (p = 0.02); and 100%, 57%, 67%, 36%, and 14% in Child-Pugh B patients (p = 0.173, not significant). Multivariate analysis showed that low ICG R15 and the absence of portal vein tumor thrombus were associated with good survival. Conclusions: Pretreatment ICG R15 is a useful prognostic factor for prediction of outcome of PBT in HCC patients, especially in those with Child-Pugh A liver function

  1. Development and validation of PCR-GLOBWB 2.0: a 5 arc min resolution global hydrology and water resources model

    Sutanudjaja, Edwin H.; van Beek, Ludovicus P. H.; Wada, Yoshihide; Wisser, Dominik; de Graaf, Inge E. M.; Straatsma, Menno W.; Bierkens, Marc F. P.

    2014-05-01

    PCR-GLOBWB (PCRaster Global Water Balance) is a grid-based global hydrological model developed at the Department of Physical Geography, Utrecht University. For each grid cell, PCR-GLOBWB simulates moisture storage in vertically stacked soil layers, as well as the water exchange to the atmosphere and underlying groundwater reservoir. Exchange to the atmosphere comprises of precipitation, evaporation and transpiration, as well as snow accumulation and melt. All fluxes are all simulated by considering vegetation phenology and sub-grid variations in elevation, land cover and soil saturation. The model includes physically-based schemes for runoff-infiltration partitioning, interflow, groundwater recharge and baseflow, as well as river routing of discharge. Here we present and summarize the latest developments of PCR-GLOBWB. The new version of the model, PCR-GLOBWB 2.0, now runs at a spatial resolution of 5 arc min (about 10 km at the equator) and supersedes the previous generation of the model (30 arc min PCR-GLOBWB 1.0, van Beek et al., 2011). PCR-GLOBWB 2.0 consolidates all components that have been introduced since PCR-GLOWB 1.0 was first published (2011). Examples of these new components are: A comprehensive water demand and irrigation module (Wada et al., 2012). A dynamic attribution and return flow of water demand to surface water and groundwater resources (de Graaf et al., 2013). An advanced surface water routing scheme with wetland, lakes and floodplains of variable extent, thus simulating flooding and flood wave attenuation (Winsemius et al., 2013). An online scheme for dynamic withdrawal, allocation and consumptive use of groundwater and surface water resources, including a progressive introduction of reservoirs (Wada et al., 2013). Further development will include the inclusion of a dynamic reservoir operation/optimization scheme and a MODFLOW lateral groundwater flow module (Sutanudjaja et al., 2011; Sutanudjaja et al., 2014). Also, scripts used for deriving

  2. La découverte du dioxyde de carbone dans les inclusions des minéraux : une grande aventure scientifique du dix-neuvième siècle

    Touret, Jacques

    1999-01-01

    International audience La fin du XVIIIe siècle a vu la naissance de la minéralogie moderne, dans une période féconde en découvertes où s'affrontaient les écoles suédoise(Berzelius et Torbern Bergman), allemande (Werner) et française (Romé de l'Isle et René-Just Haüy). Ce seront les Français qui, grâce au Traité de Minéralogie de René Just Haüy, feront la meilleure synthèse de tous ces travaux et resteront, pour la postérité, les inventeurs de la cristallographie et de la minéralogie telles...

  3. Flotabilidade da apatita e minerais de ganga provenientes de minério sílico-carbonatado com oleato de sódio Floatability of apatite and gangue minerals from silicate-carbonate ores with sodium oleate

    Michelly dos Santos Oliveira; Antônio Eduardo Clark Peres

    2010-01-01

    O beneficiamento dos minérios fosfáticos com ganga silicatada e carbonatada é estritamente necessário para aumentar a produção de concentrados fosfáticos e para suprir a demanda nacional de fertilizantes. Visando a processar esses minérios, esse trabalho estudou, através de testes de microflotação e medidas de potencial zeta, o efeito do oleato de sódio, do amido de milho e da carboximetilcelulose (CMC) na superfície dos minerais puros originários do minério sílico-carbonatado de Catalão/GO. ...

  4. Aplicação de emulsões na flotação do minério de zinco Use of emulsions in zinc ore flotation

    Tiago Alvarenga Vitorino da Silva; Marly Ávila de Carvalho; Marcel Guimarães Sigueira; Thiago Nantes Teixeira; Carlos Alberto Pereira

    2008-01-01

    Várias linhas de flotação de minérios oxidados de zinco já foram estudadas e, segundo a maioria dos pesquisadores, a flotação catiônica com altas concentrações de sulfeto de sódio, usando amina primária como coletor, tem sido a opção mais adequada para concentrar esses minérios. Nesse trabalho, investigou-se a aplicação de novos sistemas de reagentes para flotar o minério de zinco com willemita, em etapas de depressão de gangas, dispersão, sulfetização e flotação do zinco. Os testes de flotaç...

  5. ℤmin上秩-1矩阵的周长不等式及线性保持算子%Perimeter Inequality and Linear-Preserving Operators of Rank-1 Matrices over ℤmin

    张廷海; 邓中书

    2015-01-01

    利用 Boolean 秩-1矩阵的周长保持性质和 Boolean 代数 B 与ℤ min 上矩阵之间支配关系的等价性获得了ℤ min上秩-1矩阵和的周长所满足的不等式,保持其秩与周长的线性算子以及保持秩-1和周长2的性质。%Based on the preserving properties of the perimeter of Boolean rank-1 matrices and the equivalence of the dominating relation between matrices over Boolean algebra B and ℤ min , the inequality on the perimeter of the sum of two rank-1 matrices over ℤ min and the linear operator of preserving the rank and perimeter.At last it get the properties of preserving the rank and perimeter 2 of rank-1 matrices over ℤ min .

  6. MinÀstÀ toiseen : Lacanilaisen subjektin syntymÀ Anaïs Ninin House of IncestissÀ ja HélÚne Cixous'n Dedans'issa

    Rundgren, Heta

    2007-01-01

    Tutkielmassa lÀhestytÀÀn kahta modernia romaania lacanilaisen psykoanalyysin luoman viitekehyksen avulla. Tutkittavat romaanit ovat psykoanalyyttisestÀ ajattelusta vahvoja vaikutteita saaneita kasvukertomuksia. Anaïs Ninin (1903—1977) esikoisromaani House of Incest (1936) on minÀkertojan tarina aikuisen naisen seksuaalisesta ja taiteellisesta kehityksestÀ ja HélÚne Cixous’n (s. 1937) Dedans (1969) kuvaa samoin minÀkertojan nÀkökulmasta pienen tytön kehitystÀ perheessÀÀn. M...

  7. Étude de la composition minérale et organique des liqueurs de thé et de leurs caractéristiques organoleptiques : influence des paramètres physico-chimiques de l'eau

    Mossion, Aurélie

    2007-01-01

    L'analyse de la composition organique et minérale d'infusions réalisées avec différentes variétés de thés et différentes eaux a permis de montrer que la physico-chimie de l'eau (composition, pH, température) contrôle l'extraction des composés présents dans les feuilles et les propriétés organoleptiques des liqueurs obtenues. Le calcium, en particulier, présent sous forme libre, diminue l'extraction des éléments minéraux, des polyphénols et de la caféine du fait de sa grande affinité pour les ...

  8. Dersom Du, min Læser! ..

    Wille, Niels Erik

    Diskuterer problemer med anvendelse af sproghandlingsteori på illokutionære (især assertive) sproghandlinger i fiktionsfortællinger og andre tekster. Påviser at problemerne udspringer af uheldige eller ugennemtænkte formuleringer allerede i de første formuleringer af sproghandlingsteorien samt dens...

  9. Max–min distance nonnegative matrix factorization

    Wang, Jim Jing-Yan

    2014-10-26

    Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

  10. MInD: moving in the dark.

    Pepino, A; Sicignano, G; Rovani, M; D'Addio, G

    2012-01-01

    Visually-impaired people can develop several unhealthy behaviors, including the lack of physical activity or sports, due to the incomplete maturity in the control of their body in the space. This research focuses on the creation of an "exergame" - a videogame especially designed to stimulate physical exercise - that, through voice commands, allows the visually impaired users to practice physical activity and train their abilities. This tool has been developed starting from an existing dance-game, by generating some appropriate interfaces that also involve the sensory channel of sight. Our research aims to study the effects related to this exergame on the motor control mechanism in a blind children's group, aged between 8 and 13 years: it focuses also on the joint use of movement analysis systems and of videogames in order to stimulate the physical activity in these subjects. PMID:22874404

  11. Hvorfra min verden går

    Keiding, Tina Bering

    læring bliver i Luhmanns systemteori ikke forbeholdt en bestemt systemtype. Såvel levende som sociale og psykiske systemer betegnes som læren-de systemer i det omfang, de kan genindføre iagttagelser i systemet og anvende det iagttagne i deres fortsatte autopoiesis. Antagelsen om funktionel lukkethed...

  12. 3min. poster presentations of B01

    Foing, Bernard H.

    We give a report on recommendations from ILEWG International conferences held at Cape Canaveral in 2008 (ICEUM10), and in Beijing in May 2010 with IAF (GLUC -ICEUM11). We discuss the different rationale for Moon exploration. Priorities for scientific investigations include: clues on the formation and evolution of rocky planets, accretion and bombardment in the inner solar system, comparative planetology processes (tectonic, volcanic, impact cratering, volatile delivery), historical records, astrobiology, survival of organics; past, present and future life. The ILEWG technology task group set priorities for the advancement of instrumenta-tion: Remote sensing miniaturised instruments; Surface geophysical and geochemistry package; Instrument deployment and robotic arm, nano-rover, sampling, drilling; Sample finder and collector. Regional mobility rover; Autonomy and Navigation; Artificially intelligent robots, Complex systems. The ILEWG ExogeoLab pilot project was developed as support for instru-ments, landers, rovers,and preparation for cooperative robotic village. The ILEWG lunar base task group looked at minimal design concepts, technologies in robotic and human exploration with Tele control, telepresence, virtual reality; Man-Machine interface and performances. The ILEWG ExoHab pilot project has been started with support from agencies and partners. We discuss ILEWG terrestrial Moon-Mars campaigns for validation of technologies, research and human operations. We indicate how Moon-Mars Exploration can inspire solutions to global Earth sustained development: In-Situ Utilisation of resources; Establishment of permanent robotic infrastructures, Environmental protection aspects; Life sciences laboratories; Support to human exploration. Co-Authors: ILEWG Task Groups on: Science, Technology, Robotic village, Lunar Bases , Commercial and Societal aspects, Roadmap synergies with other programmes, Public en-gagemnet and Outreach, Young Lunar Explorers.

  13. 骨形态发生蛋白7对胰岛素分泌的影响及机制研究%Bone morphorgenetic protein 7 improves insulin secretion from mouse pancreatic beta cell line MIN6

    姜友昭; 曾俊; 陈兵

    2012-01-01

    Objective To determine the effect of bone morphorgenetic protein 7 ( BMP7) on insulin secretion in pancreatic beta cells. Methods The expression of three type I receptors of BMP7 , BMPR1 A, BMPR1B and ACVR1A, was detected by Western blotting in mouse pancreatic beta cell line MIN6. Then the MIN6 cells were treated respectively by PBS (control), low-, medium- and high-dose of rhBMP7 (final concentration of rhBMP7 was 10, 50, and 100 ng/ml). Then the insulin level of the culture media was detected by ELISA and the intracellular concentration of calcium was determined by laser confocal microscopy. Results BMPR1A, BMPR1B and ACVR1A were all expressed in the MIN6 cells. The insulin concentration of PBS, low-, medium- and high-dose rhBMP7 treatment was 0.42 ±0. 11, 0.63 ±0.22, 0.82+0.0.19 and 1.24 ±0. 26 ng/(ml ·μxg) , respectively. The insulin concentration of rhBMP7 treatment groups was significantly higher than that of the control (all P 0. 05). Conclusion BMP7 enhances insulin secretion significantly in pancreatic beta cells, which may be due to its regulation of calcium-independent exocytosis.%目的 探讨骨形态发生蛋白7(bone morphorgenetic protein 7,BMP7)对胰岛细胞胰岛素分泌的影响.方法 Westem blot检测小鼠胰岛细胞株MIN6中3种BMP7的Ⅰ型受体BMPR1A、BMPR 1B、ACVR1A的表达情况.将MIN6细胞分为4组:PBS对照组,重组人BMP7( rhBMP7)低、中、高剂量组(rhBMP7终浓度分别为10、50、100 ng/ml),每组设5个复孔.ELISA检测各组细胞培养基中的胰岛素分泌情况.激光共聚焦显微镜检测细胞内钙离子浓度变化.结果 BMPR1A、BMPR1B、ACVR1A均表达于MIN6细胞.PBS对照组及rhBMP7低、中、高剂量组的胰岛素浓度分别为(0.42±0.11)、(0.63±0.22)、(0.82±0.19)、( 1.24 -±0.26) ng/(ml· μg).与对照组相比,rhBMP7低、中、高剂量组的胰岛素分泌均明显增加(P<0.05).PBS对照组及rhBMP7低、中、高剂量组的细胞内钙离子浓度增加分别为(3.5

  14. Radioprotective effects of melanin-glucan complex from Fomes Fomentarius and indralin at irradiation of mice BALB/C by dose of 5.95 Gy/8.5 min

    Protective effect of melanin-glucan complex from F. fomentarius (MGC) and Russian armed forces radioprotector indralin in the model of acute exposure by dose of 5.95 Gy/8.5 min care is compared. Obtained results indicate availability at MGC and indralin both direct and indirect 'bystander effect' of DNA-protective properties, as well as severe anxiolytic activity. Thus for indralin protection factor was 0.33 when in MGC it was 2.3 times higher (0.75)

  15. Evolution saisonnière des phosphates et des composés minéraux dissous de l'azote en lagune Aby (Côte d'Ivoire)

    Métongo, B.S.

    1989-01-01

    Cette étude présente le cycle annuel des variations des orthophosphates (P-PO4) et des composés minéraux dissous de l'azote (N-NO3, N-N02 and N-NH4) dans la colonne d'eau de juillet 1984 à juillet 1985 en lagune Aby... Les valeurs maximales des sels nutritifs sont enregistrées en saison de pluies et de crues et leur distribution est fonction de la stratification physique des eaux

  16. Contribution of Fragmentary Argumentation of Qi Min Yao Shu to the Construction of Accounting Culture%《齐民要术・杂说》对会计文化建设的贡献

    2013-01-01

    Qi Min Yao Shu written by Jia Sixie has made great contributions to accounting culture , including:improving the efficiency of using fixed assets , decision predicting, taking field trips, dealing with different lands in different ways, adjusting the market, improving effectiveness and so on.The contribution of Qi Min Yao Shu to the construction of Chinese accounting culture lies in that it teaches a lesson of how to make use of "assets"reasonably and effectively.%  贾思勰《齐民要术・杂说》对会计文化的贡献很多,包括提高利用固定资产效率、预测决策、实地考察、区别对待、调节市场、提高效益等思想,其对中国会计文化建设的核心贡献就在于合理有效运用“资产”。

  17. 网络最小费用最大流双目标遗传优化算法%Bi-objective optimization of network min-cost and max-flow based on genetic algorithm

    厍向阳

    2011-01-01

    针对将网络最小费用最大流问题转化为单目标优化问题进行求解的缺陷,提出网络最小费用最大流的双目标优化模型,并引入多目标遗传算法.对最小支撑树对应的余树弦流量初始值进行编码,通过解码和回路矩阵计算流量网络树枝的流量.在网络最小费用、最大流量双目标函数和网络结点容量、网络分支容量约束条件基础上,按照多目标优化理论构建增广最小化双目标函数,依此对网络流量方案编码进行评价.使用进化算子对网络流量方案编码实施进化操作,最后通过迭代得到满意解.以矿井通风网络为例进行了测试.结果表明:网络最小费用最大流双目标遗传算法是完全可行和有效的.该算法减少了最优化模型中变量数目、提高了运算效率.%Aimed at the defect of transfering network min-cost and max-flow to single objective optimization, the bi-objective optimization model of network min-cost and max-flow was proposed, and multi-objective genetic algorithm was adopted. The flow values of remain branches were encoded and initialized by multi-objective genetic algorithm, and the flow values of tree branches were calculated by decoding and circuit matrix. Based on network min-cost and max-flow function, nodes capacity and branches capacity restrictions, the generalized bi-objective function were set up according to multi-objective optimization theory. The flow scheme codes were evaluated by the generalized bi-objective function and evolved by evolution arithmetic operators to obtain optimization min-cost and max-flow schemes by iterative algorithm. Mine ventilation network was taken as example to conduct the test. The results show that the biobjective genetic algorithm of network min-cost and max-flow is feasible and effective. The variable number is reduced in this algorithm and algorithm efficiency is improved.

  18. A pioneer in the frontier of engineering science——Zhe-Min Zheng%工程科学前沿的拓荒者——郑哲敏

    戴兰宏

    2013-01-01

    Zhe-Min Zheng,as a famous mechanician,is the founder and pioneer of explosion mechanics in China.He won the State Preeminent Science and Technology Award of China in 2012.This paper reviews the abundant research activities of Zhe-Min Zheng over the past 60 years,especially his outstanding academic contributions in the areas of explosion processing,underground nuclear explosion,blasting push-out silt,armor penetration by shaped charge jet,coal and gas outburst,natural gas hydrate mining,hydro-elastic dynamics,material mechanical behavior,etc.These achievements are marked by distinct character of engineering science,that is,they are motivated from the national significant demands,and reached by refining the critical physical factors and innovative theories from complex issues,and providing useful guide to practice.The scientific contributions and academic thoughts of Zhe-Min Zheng have great practical significance and reference value for the development of mechanics.%郑哲敏先生是著名力学家,我国爆炸力学的奠基人和开拓者,2012年度国家最高科学技术奖获得者.本文回顾了郑哲敏先生在过去60多年中非常丰富的科研活动,特别是他在爆炸加工、地下核爆、爆炸排淤、穿破甲、煤与瓦斯突出、水合物开采、水弹性动力学、材料力学行为等方面的杰出学术贡献.这些工作闪耀着鲜明的工程科学特点,即着眼国家重大需求,从错综复杂的问题中概括提炼关键物理因素,创新理论,进而指导实践.郑哲敏先生的科学贡献和学术思想,对于力学学科发展,有着重要的现实意义和参考价值.

  19. Flotabilidade da apatita e minerais de ganga provenientes de minério sílico-carbonatado com oleato de sódio Floatability of apatite and gangue minerals from silicate-carbonate ores with sodium oleate

    Michelly dos Santos Oliveira

    2010-09-01

    Full Text Available O beneficiamento dos minérios fosfáticos com ganga silicatada e carbonatada é estritamente necessário para aumentar a produção de concentrados fosfáticos e para suprir a demanda nacional de fertilizantes. Visando a processar esses minérios, esse trabalho estudou, através de testes de microflotação e medidas de potencial zeta, o efeito do oleato de sódio, do amido de milho e da carboximetilcelulose (CMC na superfície dos minerais puros originários do minério sílico-carbonatado de Catalão/GO. Os resultados obtidos mostraram a possibilidade de separação seletiva da apatita, por flotação direta em pH igual a 9, usando-se oleato de sódio como coletor, na ausência de depressores, o que seria inviável industrialmente. Tanto a CMC como o amido deprimem a dolomita, mas não são seletivos, pois deprimem, também, a apatita. O amido apresenta ação depressora sobre a apatita mais forte que a CMC.The processing of phosphate ores containing silicates and carbonates in the gangue is strictly necessary to increase phosphate rock production to meet the Brazilian demand for fertilizers. Aiming at the processing of these ores, this investigation addressed, via microfl otation and zeta potential determinations, the effect of sodium oleate, corn starch and carboxymethylcellulose (CMC on the surfaces of pure minerals from the Catalão/GO silicate-carbonate deposit. The results suggested the possibility of selective apatite concentration via direct fl otation at pH = 9, using sodium oleate as collector, in the absence of depressants; a route that would be industrially unfeasible. Both, CMC and starch, act as dolomite depressants, but the action is not selective, for apatite is also depressed by these reagents. Starch is a stronger apatite depressant than CMC.

  20. Aplicação de emulsões na flotação do minério de zinco Use of emulsions in zinc ore flotation

    Tiago Alvarenga Vitorino da Silva

    2008-03-01

    Full Text Available Várias linhas de flotação de minérios oxidados de zinco já foram estudadas e, segundo a maioria dos pesquisadores, a flotação catiônica com altas concentrações de sulfeto de sódio, usando amina primária como coletor, tem sido a opção mais adequada para concentrar esses minérios. Nesse trabalho, investigou-se a aplicação de novos sistemas de reagentes para flotar o minério de zinco com willemita, em etapas de depressão de gangas, dispersão, sulfetização e flotação do zinco. Os testes de flotação, usando emulsão de amina com óleos vegetais e diesel, mostraram que a amina emulsificada apresentou um desempenho na flotação superior à amina não emulsificada, além de permitir uma redução significativa de sulfeto de sódio. Dos óleos vegetais estudados destacaram-se a mamona e o coco-babaçu, porém os resultados de recuperação foram inferiores ao óleo diesel.Several approaches to the flotation of oxidized zinc ores were already studied, and according to most of the researchers, the cationic flotation with high concentrations of sodium sulfide, using primary amine as collector, has been the most appropriate option to concentrate this type of ore. In this work, the application of innovative systems of reagents to float willemite was investigated, including the stages of gangue depression, dispersion, sulfidization and zinc flotation. The flotation tests using amine emulsion with vegetable oils and diesel oil showed that the amine emulsion yielded a better flotation performance than that of amine without emulsion, besides allowing a significant reduction of sodium sulfide dosage. Among the vegetable oils studied castor and babaçu coconut oils yielded reasonable results, despite not leading to the same zinc recovery levels achieved with diesel oil.

  1. 王叔岷《史记斠证》商榷%The Studies on Shiji jiaozheng (《史记斠证》) by Wang Shu-min

    杨小平

    2015-01-01

    文章逐一研讨了王叔岷《史记斠证》一书中“痢儿畔”“内”“太任”“岐”“罚”“迺”等词语,进而提出了商榷观点或者思考。%This paper discusses a series of Chinese characters or expression such as Lierban (痢儿畔)、 Nei (内)、 Tairen (太任)、 Qi (岐)、 Fan (罚)、 Nai (迺) etc in Shiji jiaozheng (《史记斠证》) by Wang Shu-min, puts forward some opinions about them.

  2. Le cépage VITIS VINIFERA L. CV. FER SERVADOU : étude de la nutrition minérale et des relations cepage, terroir, qualité du vin

    Cadet, Alexandra

    2005-01-01

    L’implantation du Fer Servadou dans le sud-ouest de la France est assez importante et en constante augmentation. A ce jour, aucune étude n’a été menée sur ce cépage, mais la connaissance de ces aptitudes viticoles et oenologiques représente un enjeu important pour les viticulteurs de la région. Dans le but de mieux comprendre la physiologie de la nutrition minérale du Fer Servadou, nous avons mis en place une expérimentation en culture hors-sol. Les résultats montrent que le Fer Servadou prés...

  3. Reciclagem de aminas na flotação de minério de ferro Recycling of amines present in the residues from the reverse flotation of iron ore

    Danielle M. Araujo; Maria Irene Yoshida; Cornélio F. Carvalho; Frank Stapelfeldt

    2008-01-01

    O presente trabalho tem por objetivo investigar a possibilidade de reutilização de aminas residuais provenientes do processo de flotação de minério de ferro. Os testes de flotação em bancada foram realizados em pH 10,5, tendo o amido como depressor dos óxidos de ferro e as aminas Flotigam EDA 3B e F2835 como coletores para a sílica. Cada rejeito desses ensaios foi submetido à separação sólido/líquido através de filtração a vácuo. O líquido contendo amina residual foi reutilizado em um segundo...

  4. Interaction entre le greffon et le porte-greffe chez la vigne. Application de la méthode des greffages réciproques à l’étude de la nutrition minérale

    Pouget, Roger; DELAS, Jacques

    1982-01-01

    La méthode des greffages réciproques est utilisée pour déterminer l’influence respective de la variété porte-greffe et de la variété greffon sur la teneur en éléments minéraux (Ca Mg, K) des limbes et des pétioles. Dans ce but, cinq variétés de porte-greffes de la vigne (« Riparia », « 101-14 », « Fercal », « S04 », « 140 Ru »), ont servi à confectionner les 25 types possibles d’association greffon/porte-greffe. La teneur en Ca, Mg et K des limbes et des pétioles de ces plantes greffées, cu...

  5. Min musikk - formidlet følelse eller dokumentasjon av måloppnåelse? : Om læreplanimplementering i hovedområdet formidling i musikk fordypning i videregående skole.

    Tafjord, Magnhild

    2012-01-01

    Denne masteroppgaven “Min musikk – formidlet følelse eller dokumentasjon av måloppnåelse?” har implementering av læreplanen for Kunnskapsløftet (LK06) i hovedområdet formidling i musikk fordypning i videregående skole som tema. Jeg har valgt å undersøke dette fra et lærerperspektiv, og ser på både implementeringsprosessen og innholdet i opplæringa. Hensikten er å få innsyn i lærernes forståelse av faget etter Kunnskapsløftet, og hvordan implementering av en ny læreplan skjer. Det etiske persp...

  6. Flotação de diferentes tipologias de minério fosfático de Tapira/MG, usando o coletor óleo de soja hidrogenado

    Gilberto Caixeta Guimarães

    2004-09-01

    Full Text Available Esse trabalho teve por objetivo avaliar o desempenho do coletor óleo de soja hidrogenado na flotação de quatro tipologias de minérios fosfáticos da mina de Tapira/MG, denominadas piroxenito silicificado semicompacto, piroxenito silicificado compacto, silexito e piroxenito serpentinizado, cujas relações CaO/P2O5 eram de 2,1, 3,5, 2,5 e 1,33, respectivamente. Para a realização dos experimentos, foram aplicadas a metodologia estatística de planejamento e a análise fatorial de experimentos, onde foram estudadas as dosagens de coletor (óleo de soja, a dosagem de depressor (amido de milho gelatinizado e o pH de flotação. Verificou-se que o valor de pH ideal para a flotação dos minérios foi igual a 11, exceto para o minério silexito, que foi igual a 8. A relação CaO/P2O5 dos concentrados foi maior para os minérios com maior conteúdo de carbonatos e aumentava com o aumento da dosagem de coletor, evidenciando a baixa seletividade desse reagente para a separação entre a apatita e a ganga carbonática a ela associada. Observou-se a necessidade de etapa cleaner para obtenção de concentrados dentro das especificações de mercado para todas as amostras estudadas.In this work was studied the froth flotantion response of fuor diferent types of phosphate ores from Tapira-MG using fatty acid soap from soja as apatite colector and corn starch gelatinized as gangue depress. The CaO/P2O5 relation of the half compact silificate piroxenite, compact silificate piroxenite, silexite and serpentinized piroxenite ores samples were 2,1, 3,5, 2,5 e 1,33, respectivally. The experiments were conduct and analised using fatorial planing of experiments that studied the influence of pH, coletctor and starch concentration. The optimun pH value to float the sample ores was 11, except for silexite sample that it was 8. The increase of colector concentration conducts to concentrates with lower P2O5 content and higher CaO/P2O5 relation. The concentrates

  7. Spironolactone use and higher hospital readmission for Medicare beneficiaries with heart failure, left ventricular ejection fraction <45%, and estimated glomerular filtration rate <45 ml/min/1.73 m(2.).

    Inampudi, Chakradhari; Parvataneni, Sridivya; Morgan, Charity J; Deedwania, Prakash; Fonarow, Gregg C; Sanders, Paul W; Prabhu, Sumanth D; Butler, Javed; Forman, Daniel E; Aronow, Wilbert S; Allman, Richard M; Ahmed, Ali

    2014-07-01

    Although randomized controlled trials have demonstrated benefits of aldosterone antagonists for patients with heart failure and reduced ejection fraction (HFrEF), they excluded patients with serum creatinine >2.5 mg/dl, and their use is contraindicated in those with advanced chronic kidney disease (CKD). In the present analysis, we examined the association of spironolactone use with readmission in hospitalized Medicare beneficiaries with HFrEF and advanced CKD. Of the 1,140 patients with HFrEF (EF mEq/L. Spironolactone use had significant PS-adjusted association with higher risk of 30-day (HR 1.41, 95% CI 1.04 to 1.90) and 1-year (HR 1.36, 95% CI 1.13 to 1.63) all-cause readmissions. The risk of 1-year all-cause readmission was higher among 106 patients with eGFR <15 ml/min/1.73 m(2) (HR 4.75, 95% CI 1.84 to 12.28) than among those with eGFR 15 to 45 ml/min/1.73 m(2) (HR 1.34, 95% CI 1.11 to 1.61, p for interaction 0.003). Spironolactone use had no association with HF readmission and all-cause mortality. In conclusion, among hospitalized patients with HFrEF and advanced CKD, spironolactone use was associated with higher all-cause readmission but had no association with all-cause mortality or HF readmission. PMID:24846806

  8. Ultra-large scale synthesis of high electrochemical performance SnO{sub 2} quantum dots within 5 min at room temperature following a growth self-termination mechanism

    Cui, Hongtao, E-mail: htcui@ytu.edu.cn; Xue, Junying; Ren, Wanzhong; Wang, Minmin

    2015-10-05

    Highlights: • SnO{sub 2} quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO{sub 2} quantum dots own high electrochemical performance. - Abstract: SnO{sub 2} quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO{sub 2} quantum dots within 5 min. The formation of SnO{sub 2} is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl{sub 2}⋅2H{sub 2}O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO{sub 2} quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes.

  9. 基于最大流最小割算法的事件检测方案%Event Detection Scheme Based on Max-Flow/Min-Cut Algorithm

    张瑞华; 程合友; 梁宇

    2016-01-01

    文中把最大流最小割算法应用于无线传感网络的事件检测中,针对边沿陡峭的事件,设计事件区域检测算法( G-Cut)。该算法首先将相邻节点的传感数据转化为权值,形成流网络;利用最大流最小割算法切割流网络,获得事件边界;再根据上传信息隐含的方向,确定事件区域。以野外火灾为例进行仿真实验,结果表明:文中算法事件检测准确度高,节点计算量低;针对多事件区域,在不增加节点计算量和通信量的情况下,仍可保证其检测准确度。%In this paper, the max-flow/min-cut algorithm is applied to the event detection in wireless sensor net-works, and an event detection algorithm ( G-Cut) is proposed for boundary-abrupt events.In the algorithm, firstly, the sensing data of adjacent nodes are transformed into weight values, and thus a flow network is formed.Then, the event boundary is obtained by using the max-flow/min-cut algorithm to cut the flow network.Finally, the event area is determined according to the direction implied in upload information.Simulation results on wildfire events show that the proposed algorithm achieves a high accuracy of event detection with a small computation amount of nodes, and for multi-event regions, it can guarantee the detection accuracy without increasing the computation amount and traffic of nodes.

  10. Veteran Herbalist Doctor HU Yuan-min's Crumbs of Experience for Insomnia Patients with Cardiovascular Disease%胡源民老中医治心血管病患者失眠之点滴

    姚耿圳; 陈笑银

    2011-01-01

    胡源民老中医治疗心血管病患者失眠疗效显著,总以安神为首要治法,或滋养肝肾,或健脾开胃,或活血化瘀,或清热解毒,然治法每多相兼.此外还常采用针药并用,尤其重视宣教.兹将其常用药物特点介绍如下.%Veteran herbalist doctor HU Yuan-min's treatment on insomnia patients with cardiovascular disease has remarkable effect. His primary therapeutic method is to calm the mind; other methods include nourishing liver and kidney, or invigorating spleen and stimulating the appetite, or activating blood circulation for removing blood stasis, or clearing heat and removing toxicity, while those methods were frequently used together. In addition, he often uses acupuncture combined with herbs, and emphasizes on health education especially. The paper tries to introduce the common herbs characteristics of doctor Hu as below.

  11. Effect of particles size range on iron ore flotation Efeito da faixa de tamanho de partículas na flotação de minério de ferro

    Neymayer Pereira Lima

    2013-06-01

    Full Text Available Flotation is one of the main concentration processes being employed for many classes of minerals (sulfides, oxides, silicates, phosphates, for example at different particle sizes. In the iron ore industry, reverse quartz flotation has been successfully employed for particle sizes below ISOfim after the desliming process. The high demand for iron ore products has made flotation the main process for concentration in this industry, thus a better understanding of its mechanisms and the effect of the particle sizes in the process has become imperative. Flotation tests were carried out with three different size fractions of an itabirite iron ore, obtained using cyclone classification after desliming. The results showed distinct behaviors of the different size ranges. Higher etheramine dosages are required when coarse and fine fractions are floated separately and also this procedure is more sensitive to variations in etheramine dosages and pH values. The differences in particle size distributions and the specific surface area may explain the different flotation behavior of the distinct size fractions. The split flotation circuits for coarse and fine particles indicated an increase of 3% points in the metallurgical recovery with reduction of SiO2 content in final concentrate, increase of etheramine dosage and reduction of corn starch dosage. Economic feasibility analysis indicated a positive net present value of 50 million of dollars with split circuits for coarse and fine particles, considering a production of 10 million tons per year of pellet feed.A flotação é um dos principais processos de concentração, sendo empregada para diversas classes de minerais (sulfetos, óxidos, silicatos, fosfatos, etc., em relativamente ampla faixa de tamanhos de partículas. Na indústria de minério de ferro, a flotação reversa de quartzo tem sido empregada com sucesso para partículas abaixo de 150um, após a etapa de deslamagem. A elevada demanda por produtos

  12. Development of {sup 115}Cd/{sup 115m}ln generator for industrial and environmental applications; Desenvolvimento de um gerador de {sup 115}Cd/{sup 115m}In para aplicacoes industriais e ambientais

    Camargo, Fernanda Cristina Fonseca

    2012-07-01

    Indium isotopes, {sup 111}In, '1{sup 13}ln and {sup 115}In are widely used as radiotracers in industrial and environmental applications. {sup 113m}ln generators can be found in the international market. However they are manufactured by only a few companies worldwide, are rated at rather high prices and not always are available for sale (they are frequently manufactured only upon request). Hence it is of interest to produce the equipment in the country in which it will be used, especially if the parent nuclide can be also produced there. In Brazil, the ideal situation would be to produce a {sup 115}Cd/{sup 115m}In generator, whose target precursor is the '1{sup 14}Cd. Preliminary tests using non-enriched and inactive CdO were developed. The parent and daughter nuclides were separated flowing the eluate containing the chemical species Cd (II) and In (III) through ion exchange resins, Ag11A8, Chelex100 and Oowex 1 x8. 0.1 M, 1 M and 2M HCI and 2M HCI + 0.1 M NH{sub 4}CI solutions were tested as the eluant. The amount of Cd (l I) and In (III) eluted were determined by ICP-AES. The irradiation conditions of the target {sup 114}CdO were defined according to the neutron flux provided TRIGA MARK-I-R IPR reactor and the nuclear properties the of target. After to preliminary tests with the {sup 115}Cd/{sup 115m}In pair, column experiments were developed. Analyses were accomplished by gamma spectrometry to determine the presence of the {sup 115}Cd and {sup 115m}ln nuclides in the fractions eluted. Tests using the resin AG IIA8 and HCI I M eluent solution resulted in 100% adsorption of the Cd (11) and nearly 50% elution of In (III), corresponding to the best conditions for elution. Exposure to radiation can damage the resins, as the decrease in ion exchange capacity and change in volume of the polymer grains. Thus, columns packed with the chosen resin were exposed to radiation doses from 15 to 200 Gy, and eluted with the most effective eluent. The results showed that

  13. Prevalence tendency of soil transmitted nematode infections in Min County by sentinel surveillance from 2006 to 2010%2006-2010年岷县土源性线虫病监测点流行趋势分析

    杨俊克; 冯宇; 李凡; 陈生邦; 杨成明; 梁虹

    2012-01-01

    Objective To observe the prevalence tendency of soil transmitted nematodes infections in Min County,Gansu Province during 2006-2010 through constant surveillance on the population and soil samples detection,thus to provide evidence for making strategy of disease prevention and Control.Methods 1000 persons were investigated to find soil transmitted nematodes by sentinel surveillance.Eggs of A.Lumbricoides and T.trichiura were examined by Kato-Katz technique(3 thick smears per sample)while eggs of A.Lumbricoides examined for soil contamination in 10 families with saturate sodium nitrate floating method.The infection rates were compared among the five years.Eggs number of A.lumbricoides from soil and A.lumbricoides infection level of the families were obtained,then correlate analysis was applied.Results Soil transmitted nematodes infection rate in the population decreased from 20.31% to 11.08% in the five years,relative decreasing ratio was 44.26%.In the age group of 0-15,the infection rates were higher than those of older groups.The population with high infection rate was children live scattered,preschool children and students,respectively.Using correlate analysis by one side t test,number of soil A.lumbricoides eggs in the living environment and infection level of A.lumbricoides in those families had positive correlation,which indicated statistically significance exists (t =4.40,P < 0.10).Conclusion The infection rate of soil transmitted nematodes decreased significantly during 2006 to 2010 in Min County,but still prevailed with low incidence rate in the area.%目的 通过对甘肃省岷县国家级土源性线虫病监测点人群土源性线虫感染率和土壤蛔虫卵检出率的连续监测,观察其流行趋势,为制定防治策略提供依据.方法 2006-2010年期间,每年在岷县监测点整户调查1000人,改良加藤厚涂片法检测蛔虫、鞭虫虫卵,分析感染率;饱和硝酸钠漂浮法检测土壤蛔虫卵;对调查的10户土

  14. Une masculinité en crise à la fin du XVIIe siècle ? La critique de l'efféminé chez La Bruyère

    Cédric Corgnet

    2008-07-01

    Full Text Available L’efféminé est toujours un cas sexuel limite : homme aux airs féminins, il interroge l’innée de la nature sexuelle, critique les genres et leur définition explicitement physique. La fin du XVIIe siècle illustre cette tension chez les moralistes français et surtout chez La Bruyère dans ses Caractères où celui-ci interroge cette monstruosité générique à travers une analyse sémiologique. Mais cette tératologie n’est pas avant tout clinique mais sociale et morale : il nous avertit, par cet écart de genre, d’une corruption morale du monde tant par une sémiologie clinique que mythologique ovidienne ne cherchant pas le réalisme pathologique mais la filiation antique qui ante son ouvrage sur les Caractères Théophrastiens : philosophe plus que naturaliste.The effeminate is always a sexual limit case: man in the feminine sights, he questions the innate of the sexual nature, criticizes genders and their explicitly physical definition. The end of the XVIIth century illustrates this tension at the French moralists and especially in La Bruyère’s Characters where this one questions this generic monstrousness through a semiological analysis. But this teratology is not above all clinical but social and moral: he warns us, by this distance from gender, from a moral corruption of the world both by a clinical semiology and ovidian mythology not looking for the pathological realism but the antic filiation with Theophrast’s Characters : philosopher more than naturalist.

  15. Estudos por µXRF-Sincrotron de fluidos mineralizadores detectados em minérios uraníferos, ferríferos e depósitos epitermais

    Francisco Javier Rios

    2006-12-01

    Full Text Available O método de análise não-destrutivo denominado Microfluorescência de Raios X. (µSXRF, radiação Sincrotron tem sido utilizado recentemente em laboratórios de luz Sincrotron de vários países para identificar e, em situações especiais, quantificar elementos menores, maiores e traços em inclusões fluidas. Com esse intuito, a estação de µSXRF do LNLS (Laboratório Nacional de Luz Sincrotron, Campinas foi utilizada para desenvolver estudos composicionais de inclusões fluidas em minerais transparentes (quartzo, adulária, esmeralda, piroxênio de diferentes jazidas minerais e minérios opacos de Ag e Fe.Synchrotron radiation micro X-ray fluorescence (SµXRF analysis is a non-destructive method that can be used to identify, and in special cases, to quantify major, minor, and trace elements present in fluid inclusions. In spite of the relevant results, this technique has been used only in a few studies, which, moreover, are mostly focused on either synthetic or natural fluid inclusions in transparent minerals. To investigate fluid inclusions in transparent and opaque minerals, the synchrotron radiation X-ray microprobe station from the µSXRF fluorescence beamline at the LNLS-Campinas was used. This analytical method has been proven to be efficient in the chemical characterization of the fluid inclusions constituents of some transparent (quartz, adularia, emerald, etc. and opaque minerals (pyrargyrite and hematite.

  16. Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.

    Joanne Selway

    Full Text Available Glucagon like peptide-1 (GLP-1 is released from intestinal L-cells in response to nutrient ingestion and acts upon pancreatic β-cells potentiating glucose-stimulated insulin secretion and stimulating β-cell proliferation, differentiation, survival and gene transcription. These effects are mediated through the activation of multiple signal transduction pathways including the extracellular regulated kinase (ERK pathway. We have previously reported that GLP-1 activates ERK through a mechanism dependent upon the influx of extracellular Ca(2+ through L-type voltage gated Ca(2+ channels (VGCC. However, the mechanism by which L-type VGCCs couple to the ERK signalling pathway in pancreatic β-cells is poorly understood. In this report, we characterise the relationship between L-type VGCC mediated changes in intracellular Ca(2+ concentration ([Ca(2+](i and the activation of ERK, and demonstrate that the sustained activation of ERK (up to 30 min in response to GLP-1 requires the continual activation of the L-type VGCC yet does not require a sustained increase in global [Ca(2+](i or Ca(2+ efflux from the endoplasmic reticulum. Moreover, sustained elevation of [Ca(2+](i induced by ionomycin is insufficient to stimulate the prolonged activation of ERK. Using the cell permeant Ca(2+ chelators, EGTA-AM and BAPTA-AM, to determine the spatial dynamics of L-type VGCC-dependent Ca(2+ signalling to ERK, we provide evidence that a sustained increase in Ca(2+ within the microdomain of the L-type VGCC is sufficient for signalling to ERK and that this plays an important role in GLP-1- stimulated ERK activation.

  17. Concentração de finos provenientes da planta de beneficiamento do minério de manganês da Mineração Morro da Mina/RDM por mesa oscilatória

    Érica Linhares Reis

    2005-09-01

    Full Text Available Esse artigo apresenta estudos de concentração de finos de minério de manganês (estocados como rejeito da Mineração Morro da Mina/RDM em mesa oscilatória, visando à obtenção de concentrados para serem empregados na indústria metalúrgica. Os teores de Mn, na amostra global e nas frações acima e abaixo de 0,074 mm, eram de 28,30; 26,84 e 31,31%, respectivamente. Pela análise granulométrica, verificou-se que 80% desses finos encontravam-se abaixo de 0,149 mm. Nas condições otimizadas dos ensaios de concentração (15% de sólidos na polpa e ângulo de inclinação da mesa igual a 3º, foram obtidas recuperações de manganês da amostra global, acima e abaixo de 0,074 mm de 77, 81 e 62%, respectivamente. Os teores de manganês e impurezas, nos concentrados, para as amostras estudadas, satisfizeram as especificações químicas dos produtos comercializados pela empresa.This article presents the results of fine manganese ore from Morro da Mina Mine/RDM concentration studies using oscillatory table in order to obtain concentrates to be used in metallurgical industries. The global, the fractions above and below 0,074 mm samples manganese contents were 28,30; 26,84 and 31,31%, respectively. It was observed that 80% of the particles in global sample were below 0,149 mm. For the optimized table concentration test, solids pulp with 15% and table inclination angle of 3º, the manganese recoveries of the global, fraction above 0,074 and below 0,074 mm samples were of 77, 81 and 62%, respectively. The manganese and impurities contents in those concentrates satisfied the chemical specifications of Morro da Mina Mine/RDM products.

  18. Modelo integrado de apoio ao planejamento da rede de serviços no transporte ferroviário de cargas: aplicação para transporte de minério de ferro

    Luciano Bandeira Campos

    2011-04-01

    Full Text Available

    Resumo: Apresenta-se um modelo de otimização para auxiliar o planejamento tático ferroviário com visão integrada da rede (operações em linha e pátios, e que foi aplicado ao transporte de minério de ferro numa conhecida ferrovia brasileira, considerando o efeito congestionamento. O problema é de programação não linear inteira, e a solução foi obtida por um aplicativo computacional disponível no mercado. O objetivo é facilitar o planejamento da rede de serviços: quais trens (serviços devem ser operados, sua frequência, e a sequência recomendada das operações e serviços desde a origem das cargas até o destino. A pesquisa de literatura identificou um modelo que, mediante adaptações, foi aplicado ao fluxo de trens com diferentes opções preestabelecidas de configuração, desde 11 pontos de origem até um terminal exportador e passando por três pátios intermediários, onde os trens podem ser combinados entre si. Os resultados variam conforme a abordagem adotada para a função objetivo, com diferenças significativas na frequência dos diversos serviços disponíveis e no uso dos pátios intermediários.

    Abstract: This paper presents an optimization model developed to help tactical planning at railroads with an integrated view of the network (line and yard operations. The model was applied to iron ore transportation in a well-known Brazilian railroad, considering congestion effects. This is an integer nonlinear problem, which was solved by an optimization package. The objective is to help decision making related to service network design: which trains (services should run, how frequently and what should be the recommended sequence of activities to be performed at intermediate yards from origin to destination of cargo. Literature research identified a model that could be modified and adapted to the flow of different predefined train consist options, which are operated from 11 mines

  19. Reciclagem de aminas na flotação de minério de ferro Recycling of amines present in the residues from the reverse flotation of iron ore

    Danielle M. Araujo

    2008-12-01

    Full Text Available O presente trabalho tem por objetivo investigar a possibilidade de reutilização de aminas residuais provenientes do processo de flotação de minério de ferro. Os testes de flotação em bancada foram realizados em pH 10,5, tendo o amido como depressor dos óxidos de ferro e as aminas Flotigam EDA 3B e F2835 como coletores para a sílica. Cada rejeito desses ensaios foi submetido à separação sólido/líquido através de filtração a vácuo. O líquido contendo amina residual foi reutilizado em um segundo ensaio de flotação, onde foi investigada a dosagem de reagente novo. Utilizando-se a água contendo amina residual, juntamente com quantidades novas dos coletores, observou-se que há a possibilidade de diminuir o consumo desse reagente em até 50%. Foi realizado também teste de dessorção das aminas contidas em rejeitos sólidos, adicionando-se água ao resíduo em diferentes valores de pH e massa do resíduo. Os resultados revelaram que mais de 95 % da amina adicionada pode ser recuperada.The present work has the objective of investigating the possibility of the reuse of residual amines resulting from the process of reverse flotation of iron ore. Bench-scale flotation tests were performed at pH 10.5 with starch as the depressant of iron oxides and the amines Flotigam EDA 3B and F 2835 as silica collectors. Each waste effluent from these trials was submitted to solid/liquid separation via vacuum filtration. The liquid containing residual amine was reutilized in a second flotation trial where the concentration of the new reagent was determined. Utilizing the water containing the residual amine together with new quantities of collectors, it was observed that it was possible to reduce the consumption of this reagent by as much as 50%. A desorption test of the amines contained in the solid waste was performed by putting different masses of the residual in contact with water of different pH values. The results revealed that more than 95

  20. A influência da granulometria na flotação de rejeito de minério de zinco The influence of size distribution on the flotation of zinc ore tailings

    Mário Luís Cabello Russo

    2008-06-01

    Full Text Available No mercado mundial, o valor dos metais tem aumentado consideravelmente. Todas as empresas mineradoras estão adotando medidas com o objetivo de otimizar seus processos de concentração, sempre visando retirar a máxima quantidade de metal de interesse do minério "ROM". Esse princípio é compatível com o alvo ambiental de minimização da geração de resíduos na atividade mineral. Beneficiando-se rejeitos, objetiva-se, tanto aumentar a produção, como, também, amenizar impactos ambientais. Esse trabalho apresenta uma análise dos fenômenos interfaciais que regem a flotação de silicatado de zinco, principalmente os finos, além de parâmetros para a concentração de rejeitos do circuito de flotação de willemita. As amostras de rejeito estudadas foram fornecidas pela Votorantim Metais, unidade de vazante. Depois de determinados quais reagentes respondem melhor ao processo e quais as suas condições ideais de dosagem, foram desenvolvidos testes de flotação em faixas granulométricas específicas, com o objetivo de se analisar o efeito do tamanho da partícula no processo de flotação.In the world market, the metal prices have been increasing considerably. All mining companies have adopted actions with the objective of minimizing their concentration processes, enhancing the recovery of the metal bearing mineral from the ROM. This line is compatible with the environmental target of minimizing the generation of wastes in the mining activities. It aims at increasing the zinc production, while reducing environmental impacts. The goal of the present investigation is to analyze the interface phenomena that control the flotation of zinc silicate, mainly the fines, and to determine which conditions concentrate the tailings of the willemite's flotation circuit. The samples of tailings were supplied by Votorantim Metais, Vazante. After determining the best reagents for the flotation and their dosages, flotation's tests was carried out with

  1. Grau de saponificação de óleos vegetais na flotação seletiva de apatita de minério carbonatítico

    Jardel Alves de Oliveira

    2006-12-01

    Full Text Available Ensaios de flotação, em bancada, de amostras de minério fosfático granulado e friável de Tapira-MG foram efetuados, testando-se diferentes graus de saponificação de três coletores aniônicos: "Hidrocol parcialmente hidrogenado", "Hidrocol sem hidrogenação" (obtidos a partir de soja e ácido oléico. Os graus de saponificação usados foram de 40 %, 55 %, 70 %, 85 % e 100 %. Os ensaios foram feitos em pH 9,5. O óleo de babaçu, também cogitado como coletor, não permitiu grau de saponificação além de 40 %, mas serviu de controle da metodologia de quantificação do grau de saponificação. O Hidrocol parcialmente hidrogenado com grau de saponificação de 55 % foi o melhor, em termos de teor e recuperação de fósforo, relação CaO/P2O5 e teor de magnésia no concentrado, motivando testes de flotação em estágio de limpeza, sem e com a adição do coletor KE883B, um sulfosuccinato, também em pH 9,5, utilizando-se os óleos com grau de saponificação de 55 %. O Hidrocol parcialmente hidrogenado sem KE883B deu melhor resultado. Usou-se amido como depressor em todos os ensaios.Bench scale flotation experiments were performed testing three anionic collectors here called "partially hydrogenated Hidrocol", "non hydrogenated Hidrocol" (very similar oils from soybean and oleic acid, with saponification degrees of 40 %, 55 %, 70 %, 85 % and 100 %, in order to purify carbonatitic phosphate ores from Tapira. The value of flotation pH was 9.5. A refined babassu oil sample (extracted from the babassu palm seed kernel did not achieve a saponification degree above 40 %. Using the P2O5 content and recovery, the CaO/P2O5 ratio and MgO content of the concentrate as quality indicators, the best results were achieved with the saponification degree of 55%, for the oils tested. Cleaner lab flotation tests were carried out using the collectors with a saponification degree of 55%, at pH 9.5, in the absence and in the presence of KE883B (alkyl

  2. Caracterização da parcela magnética de minério fosfático de carbonatito Characterization of the magnetic phase from carbonatitic phosphate ore

    Alysson A. Borges

    2008-03-01

    Full Text Available O rejeito magnético do Complexo Mineração de Tapira, Tapira - MG, onde se processa rocha fosfática, foi estudado. Suas principais características físicas, químicas e mineralógicas foram determinadas, assim como suas respostas a processos de concentração. A primeira etapa do trabalho envolveu análise granulométrica, análise química, difratometria de raios X, espectroscopia Mössbauer, microscopia ótica e microscopia eletrônica de varredura. Na segunda etapa, ensaios de separação magnética, flotação e lixiviação ácida foram realizados. O material sob estudo revelou-se composto essencialmente por magnetita, hematita (martita e ilmenita. A separação magnética resultou em recuperação metalúrgica de ferro acima de 96 %. Sabão sódico de ácido graxo vegetal (Hidrocol deu melhores resultados no processo de flotação, comparado ao desempenho de amina, quando empregados como coletores de silicatos e apatita, visando à depuração dos minerais portadores de ferro. A atrição preliminar ao condicionamento não influenciou sensivelmente a flotação. Os ensaios de lixiviação visaram a eliminação de fósforo, contaminante crítico nos minérios de ferro. O ácido acético extraiu 0,41 % do fósforo presente, enquanto o ácido clorídrico extraiu em torno de 73 % do fósforo. Estudos ulteriores de otimização de tais ensaios são recomendados, buscando o uso do material sob estudo em siderurgia.The characterization of the magnetic fraction of a tail from phosphate rock processing was done. Samples were from Tapira, in Minas Gerais, Brazil. The main physical, chemical and mineralogical properties, as well as this material response to separation processes were determined. The first part of this work encompasses the mineralogical characterization (determination of particle size distribution, X-ray diffraction, Mössbauer spectroscopy, optical microscopy and scanning electron microscopy. In the second part, concentration

  3. The effects of Berberine on growth of Immorto-Min colonic epithelial cell line%小檗碱对永生化结肠细胞系生长的影响及其机制

    曹海龙; 王邦茂; 鄢芳; 陈鑫

    2011-01-01

    Objective To investigate the effects of Berberine on growth of Immorto-Min colonic epithelial cell line (IMCE) and explore its possible mechanisms. Methods IMCE cells were treated with Berberine in the absence or presence of epidermal growth factor (EGF) and TNFα. Ki-67 staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay were used to identify the cell proliferation and apoptosis respectively. Furthermore, Western blot analysis was performed to detect the epidermal growth factor receptor ( EGFR), protein kinase B (Akt) and their phosphorylation.Results ( 1 ) Proliferating activity of IMCE cells was increased after adding EGF and the proportion of cell proliferation was ( 10. 64 ± 1.41 ) %. The proportion was significantly lowed in EGF plus Berberine group [(1.81 ±0. 85)%] compared to the EGF group(P <0. 01 ), while the lowest was the Berberine group [(0.49 ± 0.42) %]. (2) The proportions of cell apoptosis were ( 8.47 ± 2. 52 ) % and (9. 39 ± 2. 13 ) %in the Berberine group and TNFt group respectively which were significantly higher compared to the normal control [(0. 27 ± 0. 30)%], both P < 0. 01. (3) The phosphorylation of EGFR was significantly increased after adding EGF and p-EGFR was decreased in EGF plus Berberine group at a concentration-dependent manner. (4) Moreover, the phosphorylation of Akt was enhanced after addition of TNFα , while the phosphorylation in the TNFα and Berberine group was inhibited compared to the TNFα group. Conclusions Berberine may suppress the proliferation and promote the apoptosis of IMCE cells. The mechanisms may relate to the inhibition of the phosphorylation of EGFR and Akt.%目的 观察小檗碱对永生化结肠细胞系(IMCE)生长的影响,探讨其可能机制.方法 IMCE细胞在存在及不存在表皮生长因子(EGF)或TNFα的情况下加入小檗碱,以Ki-67免疫细胞化学染色对有增殖活性的细胞进行标记,采用原位末端转移酶标

  4. Evaluation of Some (n,n'), (n,γ), (n,p), (n,2n) and (n,3n) Reaction Excitation Functions for Fission and Fusion Reactor Dosimetry Applications; Evaluation of the Excitation Functions for the 54Fe(n,p)54Mn, 58Ni(n,2n)57Ni, 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 93Nb(n,γ)94Nb, 113In(n,n')113mIn, 115In(n,γ) 116mIn, and 169Tm(n,3n)167Tm Reactions. Progress Report on Research Contract No 16242

    Cross section data for the 54Fe(n,p)54Mn, 58Ni(n,2n)57Ni, 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 93Nb(n,γ)94Nb, 113In(n,n')113mIn, 115In(n,γ)116mIn, 169Tm(n,3n)167Tm reactions are needed to solve a wide spectrum of scientific and technical tasks. Activation detectors based on these reactions may be used in the field of reactor dosimetry. Furthermore, the 54Fe(n,p)54Mn reaction is often used in experimental nuclear physics as a monitor reaction for measurements of unknown cross sections by means of the activation method over the neutron energy range from 5 to 15 MeV. The 93Nb(n,γ)94Nb reaction is also very promising for using in retrospective neutron dosimetry for determination of total neutron fluence during a campaign of a reactor. In the existing version of the International Reactor Dosimetry File and the new extended version named as IRDFF data for excitation functions of 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 113In(n,n')113mIn, and 169Tm(n,3n)167Tm reactions are absent. Data for these reactions are also absent in the JENDL/D-99 dosimetry file. Excitation functions of 67Zn(n,p)67Cu and 169Tm(n,3n)167Tm are presented in the TENDL-2012, EAF-2010, JENDL-4.0, JEFF-3.1/A, MENDL-2 libraries. Cross section data for the 67Zn(n,p)67Cu reaction up to 20 MeV are given also in the JENDL/HE-2007 library. Excitation functions of the 92Mo(n,p)92mNb and 113In(n,n')113mIn reactions are evaluated in the EAF-2010 and JEFF-3.1/A libraries. Cross section data for the 113In(n,n')113mIn reaction are given also in the TENDL-2010 library. It is necessary to note that neutron data in the JEFF-3.1/A and JENDL-4.0 libraries were evaluated up to 20 MeV. Neutron data in the TENDL-2012, EAF-2010, MENDL-2 and TENDL-2010 libraries had been evaluated up to 30 MeV, 60 MeV, 100 MeV and 200 MeV, respectively. Neutron cross sections in the MENDL-2, TENDL-2010 and TENDL-2012 libraries had been obtained on the basis of pure theoretical model calculations and are not appropriate for reactor and fusion dosimetry

  5. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group

    Pfreundschuh, Michael; Kuhnt, Evelyn; Trümper, Lorenz;

    2011-01-01

    The MInT study was the first to show improved 3-year outcomes with the addition of rituximab to a CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-like regimen in young patients with good-prognosis diffuse large-B-cell lymphoma. Extended follow-up was needed to establish long-ter...

  6. ak_sc_2min.new.grd

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission...

  7. "Minähi halluon mukkaan" -osallistumisen merkitys vanhuksen hyvinvoinnille

    Leinonen, Anna-Kaisa

    2011-01-01

    Opinnäytetyöni tarkoitus oli kartoittaa Vanhain Ystävät ry. jäsenten kokemuksia yhdistyksen toiminnasta. Tavoitteena oli saada tietoa jäsenten odotuksista yhdistyksen tulevan toiminnan kehittämiseksi. Vanhain Ystävät ry. halusi opinnäytetyöni avulla saada tietoa, miten jäsenet kokevat yhdistyksen toiminnan ja mitä he toivovat toiminnan olevan tulevaisuudessa. Opinnäytetyöni oli luonteeltaan laadullinen tutkimus. Opinnäytetyössäni käytin avointa haastattelua, jossa minulla oli muutama tuki...

  8. Hawaiian Islands Gravity Data per 2 min Cell (96)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for the Principal Hawaiian Islands displays the distribution of about 61,000 terrestrial and marine gravity data held in the National...

  9. Keep Kids' Mouths Healthy: Brush 2min2X

    ... More about BRUSHING Visit a Dentist Visit a Dentist Take your kids to see a dentist no ... and freshen breath. Visit a dentist Visit a Dentist Kids and parents – it’s important to visit ...

  10. OnlineMin: A Fast Strongly Competitive Randomized Paging Algorithm

    Brodal, Gerth Stølting; Moruz, Gabriel; Negoescu, Andrei

    2012-01-01

    n the field of online algorithms paging is one of the most studied problems. For randomized paging algorithms a tight bound of H k on the competitive ratio has been known for decades, yet existing algorithms matching this bound have high running times. We present the first randomized paging...

  11. Shaping of ferromagnetic wall for linked min.-B configuration

    A possibility to form a linked minimum-B configuration by the use of ferromagnetic materials is studied analytically. In particular both l = 2 and l = 3 cases are investigated in detail. By arrangement of the helically modulated, bumpy wall in a periodical array, the linked minimum-B system is able to be constructed. A typical case of wall arrangement is also illustrated. (author)

  12. Nuclear orientation of the 60 min 148TbGd

    Kracíková, T. I.; Dupák, Jan; Finger, M.; Janata, A.; Kumar, K.; Lebedev, N. A.; Pavlov, V. N.; Tlustý, P.; Shchus, A. F.; Slunečka, M.

    2000-01-01

    Roč. 50, Supp. S1 (2000), s. 279-284. ISSN 0011-4626. [Symmetry and Spin. Praha, 05.09.1999-12.09.1999] Institutional research plan: CEZ:AV0Z2065902 Subject RIV: JR - Other Machinery Impact factor: 0.298, year: 2000

  13. 2.5-min gravity grid of N. America

    National Oceanic and Atmospheric Administration, Department of Commerce — The dgrav gridded data set was produced by NGDC by regridding the Decade of North American (DNAG) 6-km gravity grid of N. America. A grid cell dimension of 2.5...

  14. Detection of 160 min solar intensity variations: Sampling effect

    The hypothesis that the 2h40m period in the Crimean and Stanford global solar velocity oscillation measurements, which is close to a 1/9 of a day, might be produced partly by a 1-day sampling regularity in observations, is checked using the IR center-limb intensity variations measurements. We find: a) The power spectrum of the series of these data does show a peak near the 2 h 40 m period. b) Power spectra of the series with observing windows 'filled' with a constant do not exhibit a significant peak at the 9th harmonic of a day, nor do the power spectra of the set with observing windows 'filled' with randomly generated numbers. Accordingly, we conclude that the analysis performed on the really observed data is not biased by the effect of data windows and a 1-day sampling regularity of observations. (orig.)

  15. Ruokapalvelunlaadun kehittäminen Ravintola Min´Annissa

    Heikkinen, Tia

    2012-01-01

    Tämän opinnäytetyön tarkoituksena oli selvittää Ravintola Min’Annin asiakkaiden tämänhetkinen mielipide ravintolan ruoasta. Lisäksi haluttiin mielipiteet ravintolasta ja henkilökunnasta. Tavoitteena oli ruokapalvelulaadun kehittäminen Ravintola Min’Annissa teoriatietoa ja tutkimustuloksia apuna käyttäen. Kysymyksessä on Taipalsaarella sijaitseva ravintola Min’Ann. Ravintola tarjoaa ruoka- ja viihdepalvelua. Teoriaosuus koostuu ruokapalvelusta, asiakaspalvelusta ja asiakastyytyväisyydestä. ...

  16. On the Min-cost Traveling Salesman Problem with Drone

    Ha, Quang Minh; Deville, Yves; Pham, Quang Dung; Hà, Minh Hoàng

    2015-01-01

    Once known to be used exclusively in military domain, unmanned aerial vehicles (drones) have stepped up to become a part of new logistic method in commercial sector called "last-mile delivery". In this novel approach, small unmanned aerial vehicles (UAV), also known as drones, are deployed alongside with trucks to deliver goods to customers in order to improve the service quality or reduce the transportation cost. It gives rise to a new variant of the traveling salesman problem (TSP), of whic...

  17. Rør blot ikke ved min Thailands-tur

    Petersen, Lars Kjerulf

    2010-01-01

    Klimabevidsthed er ved at blive en fast understrøm i danskernes kollektive bevidsthed. Men klimahensyn er dog langt fra lige så selvfølgeligt som hensynet til velfærd eller øget økonomisk vækst. Og hensyn til miljøet er ligefrem et ugyldigt argument i mange sammenhænge. F.eks. udløser det kold...

  18. Alaska Gravity Data per 2 x 4 min Cell (96)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' x 4' gravity density grid for Alaska displays the distribution of about 1.1 million terrestrial and marine gravity data held in the National Geodetic Survey...

  19. Herfra min verden går - Flygtningekrisen indefra

    Faarup, Astrid; Have, Benedikte; Andersen, Line Cecilie; Aare, Signe Marie; Slouborg, Anne Sofie; Andersen, Anne Bjerning Berg

    2016-01-01

    The study investigates Syrian refugees life situation and opportunities through the lenses of existential psychology and crisis- and trauma psychology. We have taken three Syrian refugees own narration about their past in Syria, their experience of fleeing and current situations as the basis for our theoretical discussion. Our interviewees all have individual stories and individual understandings of the world. However their understanding of their life situation and possibilities all depend on...

  20. Mexico Gravity Data per 2 min Cell (97)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for Mexico, North-Central America, and the Western Caribbean Sea shows the distribution of about one million terrestrial and marine...

  1. U.S. Gravity Data per 2 min Cell (96)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for the conterminous United States displays the distribution of the about 1.8 million terrestrial and marine gravity data held in the...

  2. PR/VI Gravity Data per 2 min Cell (96)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for Puerto Rico and the Virgin Islands displays the distribution of about 26,000 terrestrial and marine gravity data held in the...

  3. Fatores perinatais associados a recém-nascidos de termo com pH<7,1 na artéria umbilical e índice de Apgar <7,0 no 5º minuto Perinatal factors associated with pH<7.1 in umbilical artery and Apgar 5 min <7.0 in term newborn

    Patrícia de Moraes De Zorzi

    2012-08-01

    Full Text Available OBJETIVO: Avaliar os fatores perinatais associados a recém-nascidos de termo com pHPURPOSE: To assess perinatal factors associated with term newborns with pH<7.1 in the umbilical artery and 5th min Apgar score<7,0. METHODS: Retrospective case-control study carried out after reviewing the medical records of all births from September/1998 to March/2008, that occurred at the General Hospital of Caxias do Sul. The inclusion criterion was term newborns who presented a 5th min Apgar score <7.0 and umbilical artery pH<7.10. In the univariate analysis, we used the Student's t-test and the Mann-Whitney test for continuous variables, the c² test for dichotomous variables and risk estimation by the odds ratio (OR. The level of significance was set at p<0.05. RESULTS: Of a total of 15,495 consecutive births, 25 term neonates (0.16% had pH<7.1 in the umbilical artery and a 5th min Apgar score <7.0. Breech presentation (OR=12.9, p<0.005, cesarean section (OR=3.5, p<0.01 and modified intrapartum cardiotocography (OR=7.8, p<0.02 presented a significant association with the acidosis event. Among the fetal characteristics, need for hospitalization in the neonatal intensive care unit (OR=79.7, p <0.0001, need for resuscitation (OR=12.2, p <0.0001 and base deficit were associated with the event (15.0 versus -4.5, p<0.0001. CONCLUSION: Low Apgar score at the 5th min of life associated with pH<7.1 in the umbilical artery can predict adverse neonatal outcomes.

  4. The Comparison between Adaptive Approach and Max-min Ant Colony Algorithm for Logistics Vehicle Routing Optimization%自适应和最大最小蚁群算法的物流车辆路径优化比较

    陈昌敏; 谢维成; 范颂颂

    2011-01-01

    Aiming at the drawbacks of slow convergence speed and being easy to fall into local optimal point for basic ant colony algorithm in logistics vehicle routing optimization issue, this paper adopted an adaptive ant colony algorithm and the max-min ant colony algorithm to overcome the basic ant colony' s shortcomings.The analysis and comparison for the two algorithms were conducted,and the simulation of vehicle routing optimization in Matlab environment using adaptive and max-min ant colony algorithm was performed as well.Experimental results show that the max-min ant colony algorithm is better than adaptive ant colony algorithm in convergence speed and shortest path search, so max-min ant colony algorithm is superior to adaptive ant colony algorithm for logistics vehicle routing optimization.%针对物流车辆路径优化问题,考虑到基本蚁群算法有收敛速度慢、易陷入局部最优的缺点,采用了自适应蚁群算法和最大最小蚁群算法进行车辆路径优化,分析、比较了这两种算法的不同并在Matlab上做了仿真.仿真实验结果显示自适应蚁群算法在收敛速度和寻找最短路径上都略逊于最大最小蚁群算法,最大最小蚁群算法在物流车辆路径优化上优于适应蚁群算法.

  5. Effet des essences forestières sur la biodégradation des matières organiques : impact sur la dynamique et le cycle du carbone, de l’azote et des éléments minéraux

    Moukoumi, Judicäel

    2006-01-01

    Cette étude visait à déterminer les indicateurs pertinents de la dynamique des matières organiques (MO) et de certaines étapes du cycle du carbone, de l'azote et des éléments minéraux en relation avec la nature des essences. Le site expérimental de Breuil-Chenue (Morvan), permettant dans des conditions identiques, de suivre l'effet des essences, a servi de support aux travaux. Les différentes approches expérimentales (in situ et au laboratoire) montrent que 30 ans après la plantation, l'expre...

  6. Aplicação da espectroscopia de reflectância difusa na quantificação dos constituintes de bauxita e de minério de ferro Application of diffuse reflectance spectroscopy in the quantification of the constituents of bauxite and iron ore

    Ana Cláudia Carioca

    2011-06-01

    Full Text Available Esse trabalho teve como objetivo a aplicação da espectrofotometria de reflectância difusa no desenvolvimento de uma metodologia para a identificação e quantificação de minerais presentes na bauxita e nos minérios de ferro. Amostras selecionadas contendo uma variabilidade mineral foram coletadas na região do Quadrilátero Ferrífero e na região de Carajás e os teores dos diferentes minerais foram estimados a partir de uma combinação de métodos convencionais, tais como análise química, difração de raios X, espectroscopia Mössbauer, susceptibilidade magnética e microscopia ótica. Os dados espectrais obtidos na reflectância difusa nas regiões do visível e do infravermelho juntamente com a composição mineralógica foram analisados por algoritmos quimiométricos. A análise de correlação mineralógica apresentou resultados satisfatórios, tendo parâmetros estatísticos médios próximos de R² = 0,93, para bauxita, e de R² = 0,87, para minério de ferro. Por exemplo, para a goethita, presente no minério de ferro, o R² = 0,96; com erro-padrão médio de calibração (RMSEC = 3,6%, e, para a hematita, presente também no minério de ferro, o R² = 0,90 com o RMSEC = 7,3%. Os resultados sugerem que a espectroscopia de reflectância difusa é uma ferramenta promissora para a quantificação simultânea dos minerais presentes em bauxita e minério de ferro.This paper describes the application of diffuse reflectance spectroscopy in the development of a methodology for the identification and quantification of minerals in bauxite and iron ores. Selected samples containing a mineral variability were collected from the Iron Quadrangle (Minas Gerais mines and from the region of Carajás (Pará. The different mineral concentrations were estimated from a combination of conventional methods such as chemical analysis, Mössbauer spectroscopy, Xray diffractions, magnetic susceptibility and optical microscopy. Diffuse reflectance

  7. Effect of Clay Mineralogy and Exchangeable Cations on Permeability of Saudi Sandstone Reservoirs Effet de la minéralogie des argiles et des cations échangeables sur la perméabilité des réservoirs gréseux d'Arabie Saoudite

    Dahab A. S.

    2006-11-01

    Full Text Available Reservoir rocks are susceptible to formation damage during secondary recovery operations due to the particular mineralogical, textural and electrochemical properties of the clay minerals they contain. This damage can be explained by the swelling of indigeneous clays present, resulting in the constricting of pores, or by the dispersion of indigeneous nonswelling particle rearrangements during fluid flow, resulting in the plugging of the pore system, or by a combination of the two. This article describes a laboratory study showing the effect of clay mineralogy on the permeability of actual Saudi sandstone reservoirs during water flooding operations. The study shows that the permeability damage of Saudi sandstone reservoirs depends upon the amount of swelling clays and exchangeable ions as well as on the nature of these ions. Monovalent cations cause more damage than multivalent ones but within the same group of metals, those with smaller atomic mass cause more damage. Les roches réservoirs peuvent être endommagées pendant les opérations de récupération secondaire à cause des propriétés minéralogiques, texturales et électrochimiques particulières des minéraux argileux qu'elles contiennent. Cet endommagement peut s'expliquer, soit par le gonflement des argiles qui conduit à un rétrécissement des pores, soit par la migration de particules non gonflantes pendant l'écoulement des fluides qui entraîne le colmatage des milieux poreux, soit par une combinaison des deux mécanismes. Cet article présente une étude de laboratoire montrant l'effet de la minéralogie des argiles sur la perméabilité des roches réservoirs réelles d'Arabie Saoudite pendant des opérations d'injection d'eau. L'étude montre que l'endommagement de la perméabilité des roches réservoirs d'Arabie Saoudite dépend de la quantité d'argiles gonflantes et d'ions échangeables, ainsi que de la nature de ces ions. Les cations monovalents provoquent plus d

  8. Caractérisation géochimique et isotopique dans un système d'altération complexe, du protolithe magmatique à la minéralisation Fe-Pb-Zn: le cas de la mine de Tamra (N. Tunisie)

    Decrée, Sophie

    2008-01-01

    L’objectif principal de cette thèse est de décrire et interpréter la mise en place des différents types de minéralisations présents dans le district minier de Nefza (NO de la Tunisie), qui constitue une région complexe et particulière du point de vue géologique dans ce pays.En effet, outre la présence de diapirs triasiques (commune à tout le Nord de la Tunisie), le district minier de Nefza est caractérisé par :(1) la mise en place d’épaisses nappes au Néogène qui forment le substratum sédimen...

  9. A Sociolinguistic Survey of the Address Forms for Young Female Customers:A Case Study in Guangdong Dianbai Min Dialect%青年女性顾客称谓语的社会语言学调查--广东电白闽方言的个案研究

    崔少娟

    2014-01-01

    广东电白闽方言区对青年女性顾客的通用称谓语是“靓妹”“靓姐”,极少使用“美女”称呼。根据电白闽方言区青年女性顾客的称谓语的使用频率来分析其原因,发现交际双方的爱美心理、称谓语本身的语音条件、商业交际场所的不同、发话者性别和年龄的差异、地方民俗文化色彩等因素对青年女性顾客的称谓语的选用有很大的影响和制约。%The common address forms for young female customers in Guangdong Dianbai Min Dialect area are “li-angmei” and “liangjie”, while “meinu” is rarely used.We analyze the reasons according to the Frequency of ad-dress forms for young female customers in Guangdong Dianbai Min Dialect area , and found that the factors influence and restrict the selection of address forms for young female customers are the love for beauty of the communicative parties, the voice conditions of the address forms , the difference of business communication places , the gender and age differences of the speakers and local folk culture.

  10. Baheji, a Unique Seasoning in the 6th Century of China -- Interpretation of Baheji, a Seasoning Captured in Qi Min Yao Shu%中国六世纪之特色复合调料:“八和銮”——《齐民要术》“八和銮”之文化解读

    金洪霞; 郭华波; 赵建民

    2012-01-01

    《齐民要术》卷八中记载的“八和盎”,是由八种不同风味的原料调制而成的辛香味型复合调料,是专门用来佐食“脍”肴的佳品。我国古代美味“銮”有多种,各有风味特色。《齐民要术》关于“八和盎”的记载,弥补了历史文献无“金銮”描述的缺憾,也创立了记录菜肴制作工艺的典范,保留了失传的《食经》中的珍贵资料,具有重要的历史文化价值。%Baheji, which is captured in Qi Min Yao Shu or Important Arts for the People' s Welfare, an ancient Chinese book on agriculture, is a compound seasoning produced by mixing 8 different ingredients. It is exclusively used to enhance the flavor of food. There are a variety of Ji in the ancient China, each featuring a unique flavor. The description of Baheji by Qi Min Yao Shu fills the relevant gap in the historic literature of food. Besides, it also sets a model in recording the art of preparing food and preserves the valuable material from Shijing, a legendary masterpiece on food culture. Therefore, the chapter of Baheji is of remarkable his- torical value.

  11. Características físicas dos minérios de caulim das minas floresta, Cavalheiro, Turvo e Kowalski, em Campo Alegre (SC, e de Trigolândia (PR Physical characteristics of kaolin ores from Floresta, Cavalheiro, Turvo and Kowalski Mines (SC and from Trigolândia Mine (PR

    J. C. Biondiv

    2000-06-01

    Full Text Available A OXFORD fez, em seus minérios, 244 determinações de resistência a flexão, 1601 determinações da retração do minério a 110 ºC, 1508 determinações da retração após queima a 1220 ºC, 877 determinações de perda ao fogo, 1544 de absorção de água, 2288 determinações da dilatação linear a após secagem a 110 ºC e 1128 da dilatação linear após queima a 1220 ºC. Os valores médios, máximos, mínimos e as distribuições dos resultados dessas análises estão mostrados em tabelas e gráficos. Essas determinações e as observações de campo mostram que os depósitos estudados são de dois tipos, denominados Modelo Trigolândia, derivado de pegmatitos, e Modelo Floresta, derivado de rochas vulcânicas ácidas. Com exceção do minério da Mina do Turvo, as médias dos valores das propriedades físicas analisadas estão sempre dentro do intervalo de valores suportado pelo processo industrial da OXFORD. O minério verde, quase todo da Mina Turvo, e o minério marron são os que têm propriedades mais discordantes dos padrões desejados. Nas correlações entre os valores médios das propriedades físicas analisadas foi constatado que as correlações ruins são sempre devidas ao minério de Trigolândia. Considerando todos os valores analisados e não mais as suas médias, nota-se que, com exceção da correlação entre a % de retração após secagem a 110 ºC e a % de retração total, com r = 0,78, todos os outros coeficientes de correlação são muito baixos, menores que 0,60.OXFORD has made 244 determinations of modulus of rupture, 1601 determinations of dry contraction 110 ºC, 1508 determinations of fired contraction 1220 ºC, 877 determinations of ignition loss, 1544 determinations of apparent porosity, 2288 determinations of dry linear dilation (dried at 110 ºC and 1128 determinations of fired linear dilation (fired at 1220 ºC on their kaolin ores. The averages, maximum, minimum and the statistical distribution

  12. 《民报》阵营分野与辛亥革命前后政治舆论的媒介镜像%Min Bao Camp Distinction and the Media Mirror of Public Opinion about Politics around the Revolution of 1911

    王天根

    2012-01-01

    辛亥革命前后的政治舆论动员涉及“革命”学理论证。《民报》作为话语系统,其对革命的表述策略在政治宣传中有集中的表现。《民报》被查禁本属媒介事件,引发巨大反响,并迅速演化成政治事件。查禁前后的政治语境及其相联系的舆论氛围尤其值得重视。章太炎主持下的《民报》逐步改变了早期激进与和缓的折中的办报路线,益发地偏左。这涉及革命阵营内部老同盟会与原光复会之间的分野,特别是孙中山与章太炎之间的矛盾。后来者常据此将《民报》停刊完全归结革命思想分歧的产物,实际上,《民报》的停刊有着更为广阔的政治背景,它关联世界范围内远东政治格局的变迁。面对中关、中日、关日关系联动中的利益抉择,为避免将清延推向关国的怀抱,日本对清廷及革命者采取了均势外交策略。这亦是《民报》第二十四号暂时停刊的重要原委。《民报》被查禁事件发生在辛亥革命前夕,《民报》被查禁的历程及局内、局外人解读,反映出革命元首与政治资源获取、日本外交策略及其对华政治舆论控制等种种联动关系造成复杂纠结的历史变数。%Around the Revolution of 1911, the mobilization of public opinion about politics was related to the revolutionary theory. Min Bao, as a language system, its representation of the revolution in political propaganda strategy had focused on performance. Its prohibition triggering a huge response, and quickly evolved into a political event. The political context and its associated atmosphere of public opinion around the prohibition should be particularly noteworthy. Min Bao which led by Zhang Taiyan use a compromised way to express their opinion, but now they gradually changed their routes of the early radical and moderate compromise the newspaper route, all the more to left. This involves the revolutionary camp

  13. 标准通道与微通道经皮肾镜治疗感染性肾结石的对比研究%A comparative study of standard percutaneous nephrolithotomy and Min - percutaneous nephrolithotomy in treatment of renal struvite calculi

    张林林; 吴卫真; 朱李兵; 朱凌峰; 王栋; 谢星; 林若飞

    2011-01-01

    目的 研究经皮肾镜标准通道与微通道碎石术治疗感染性肾结石疗效和安全性.方法 回顾分析2006 年1 月至2010 年6月我院138例(149例次)应用经皮肾镜术治疗肾脏感染性结石患者的资料.其中采用标准通道83例次,采用微通道66例次.对两组患者结石清除率、手术时间和手术并发症等指标进行比较分析.结果 两组患者均分别成功建立24F和18F肾穿刺通道.两组清石率比较:标准通道组与微通道组Ⅰ期单通道结石清除率分别为71.08%(59/83)、48.48%(32/66),P0.05;两组术后血细菌培养阳性分别为18例、24例,P 39℃)分别为10例、13例,P>0.05.结论 标准通道经皮肾镜术具有手术时间短、清石效率高、低压灌注及感染率低,术后菌血症发生率低等优点,在处理感染性肾结石方面优于微小通道经皮肾镜术.%Objective To compare the efficacy and safety of standard percutaneous nephrolithotomy( S - PCNL) and Min - percutaneous nephrolithotomy( MI - PCNL) in the treatment of renal struvite calculi. Methods Clinical data of 138 patients with renal struvite calculi who underwent PCNL from January 2006 to June 2010 in our hospital were retrospectively analyzed. S - PCNL and MI - PCNL were performed in 83 and 66 cases respectively. Stone -free rate ,operative time and complications were compared. Results 24F and 18F percutaneous renal assess were successfully established in the S - PCNL and MI - PCNL groups respectively. The single channel stone- free rate at phase Ⅰ was 71.08% (59/83)in the S- PCNL group and 48.48% ( 32/66 ) in the MI - PCNL group with difference being significant ( P < 0. 05 ). The total stone - free rate at phase Ⅰ was 80.72% ( 67/83 ) in the S - PCNL group and 60.60% ( 40/66 ) in the MI - PCNL group(P <0.05 ). The operative time was(95 ± 16) min in the S - PCNL group and( 120 ±15 )min in the MI- PCNL group( P <0.05 ). Mean blood loss in the operation was( 136 ± 9

  14. Influence de la nature chimique et minéralogique des argiles et du processus de fabrication sur la qualité des carreaux céramiques Influence of chemical and mineralogical nature of clay and manufacturing process on the quality of ceramic tiles

    Sadik C.

    2012-09-01

    Full Text Available La présente étude correspond à une approche pluridisciplinaire menée en étroite collaboration entre des géologues, des chimistes et des industriels de la céramique. Les résultats confirment l’étroite relation existante entre la composition des argiles et la qualité du produit céramique final. Les briquettes obtenues, dans les mêmes conditions, à partir de deux argiles marocaines assez différentes du point de vue chimique et minéralogique, présentent des caractéristiques technologiques bien distinctes. l’utilisation d’adjuvants minéraux, bien sélectionnés, contribue à l’équilibrage des argiles brutes et conduit à une nette amélioration de la qualité du produit céramique, notamment une réduction de leur retrait à la cuisson et une augmentation de leur résistance à la flexion. Concernant l’effet du processus de fabrication, l’application de l’engobe et de l’émail, s’avère être à l’origine de bombement des carreaux lors de la cuisson, en raison vraisemblablement de la différence des coefficients de dilatation des deux milieux argile et émail. This study is conducted in a multidisciplinary collaboration between geologists, chemists and industrial ceramics. The results confirm the close ralatioship existing between the composition of clays and quality of the finished ceramic pieces. The obtained specimens, under the same conditions, from two moroccan clays that are different on the chimico-mineralogical point of view, present distinct technological characteristics. The use of well selected mineral adjuvants, contributes to the balancing of raw clays and leads to a marked improvement in the quality of the ceramic product, including a reduction on their firing shrinkage and an increase of flexural strength. Concerning the effect of the manufacturing process, the application of the glaze, turns out to be the cause of bulging tiles during firing, probably because of the difference in thermal

  15. 相关性分析和最大最小蚁群算法用于脉搏信号的情感识别%Affective Recognition from Pulse Signal Using Correlation Analysis and Max-Min Ant Colony Algorithm

    陈红; 刘光远; 赖祥伟

    2012-01-01

    For the affective recognition from pulse signal,a new approach was presented, which combined correlation a-nalysis and max-min ant colony algorithm. The effective feature subset which can identify the affective recognition model with better performance was found. Firstly, sequential backward selection(SBS) was used for sorting the original features. Secondly, the linear correlation coefficient was presented for calculating the correlation between features, and some features were removed which had greater correlation according to the result of sorting. Finally,max-min ant colony algorithm realized feature selection which searched for an optimal subset based on the compact feature subset,and combined with Fisher classifier to finish classification of six emotions which include happiness,surprise,disgust,grief,anger and fear. The experiments show that the proposed approach can find the more stable and effective feature subset from the original feature set, and establish effective affective recognition model.%针对脉搏信号的情感识别问题,提出了一种相关性分析和最大最小蚁群算法相结合的方法,找出了对情感识别模型构建具有较好性能的稳定特征子集.首先将原始特征用序列后向选择(SBS)方法排序,然后利用线性相关系数分析法计算特征间的相关度,并根据排序结果去除部分相关度较大的特征,最后针对筛选后的特征子集用最大最小蚁群算法进行特征选择,并结合Fisher分类器对高兴、惊奇、厌恶、悲伤、愤怒和恐惧6种情感进行分类.实验结果表明,该方法能在原始特征集合中找出更稳定有效的特征子集,从而建立起有效的情感识别模型.

  16. Caracterização tecnológica dos tipos de minério de fosfato do Complexo Alcalino de Salitre, MG - Área Fosfertil Technological characterization of phosphate ore types from the Salitre Alkaline Complex, MG - Fosfertil Area

    Daniel Uliana

    2009-12-01

    Full Text Available São apresentados os resultados de caracterização tecnológica de seis tipos de minério fosfático provenientes do Complexo de Salitre, tendo em vista definir a composição mineralógica das amostras e as características inerentes à apatita e ao minério relevantes para o beneficiamento mineral. Os teores de P2O5 variam de 9 a 25% e a proporção de finos (-0,020 mm situa-se entre 20 e 34% em massa com perdas associadas de 17 a 22% do total de P2O5 presente. As amostras são compostas, essencialmente, por apatita, oxi-hidróxidos de ferro, ilmenita, argilominerais, carbonatos, quartzo, piroxênio, perovskita, alumino-fosfatos e outros minerais acessórios, variando apenas suas proporções relativas. Verificou-se que a apatita ocorre, predominantemente, liberada já abaixo de 0,21 mm, com superfície límpida a fracamente impregnada por oxi-hidróxidos de ferro; a parcela altamente impregnada (não flotável varia de 6 a 9%. Do total de fósforo contido nas amostras, mais de 97% ocorre sob a forma de apatita (acima de 0,020 mm e a recuperação potencial estimada de P2O5 na etapa de flotação é superior a 90% (recuperação global estimada entre 71-76%.The present study was carried out on six different ore types from the Salitre Alkaline Complex aiming to determine their mineralogical composition and the major features that are relevant in the mineral processing. The P2O5 grades vary from 9 to 25%. The slime content (-0,020 mm varies between 20 and 34% (w/w and carries 17-22% of the P2O5 content. The samples essentially consist of apatite, iron oxi-hydroxides, ilmenite, clayminerals, carbonate, quartz, pyroxene, perovskite, secondary phosphates and other minor accessory minerals. Below 0.21 mm, apatite essentially occurs in free particles showing a clean surface or a weak coating of iron oxi-hydroxides; the highly covered apatite (not recoverable by flotation varies from 6 to 9%. In the deslimed fraction (above 0.020 mm more than 97% of

  17. Bacterial leaching kinetics for copper dissolution from a lowgrade Indian chalcopyrite ore Cinética de lixiviação por bactéria para a dissolução de cobre de um minério de calcopirita de baixo teor encontrado na Índia

    Abhilash

    2013-06-01

    Full Text Available Bio-leaching of copper (0.3% from a low grade Indian chalcopyrite ore of Malanjkhand copper mines, using a native mesophilic isolate predominantly Acidithiobacillus ferrooxidans (A.ferrooxidans, is reported. A bio-recovery of 72% Cu was recorded in the presence of this culture (not adapted, which increased to 75% with an ore adapted culture after 35 days at 35ºC and pH 2.0 with Biolixiviação de cobre (0,3% de um minério de calcopirita de baixo teor, extraído em minas de Malanjkhand, usando um isolador mesofílico nativo, predominante Acidithiobacillus ferrooxidans (A.ferrooxidans, é apresentada. Uma biorrecuperação de 72% Cu foi registrada na presença dessa cultura (não adaptada, que aumentou para 75% com a cultura do minério adaptado e cultivado por 35 dias ao 35ºC e pH 2,0, com <50um partículas. Os dados cinemáticos mostraram mais adequados para o modelo básico de encolhimento controlado por difusão, exibindo lotes lineares de [1- 2/3X- (1-X2/3] vs temp (X - fração lixiviada. Parece que o papel da bactéria, no processo, é o de converter o íon ferroso para o estado férrico, que oxida a calcopirita para poder dissolver o cobre, mantendo o alto potencial redoxante. O valor da energia de ativação (E foi calculado em 96 e 108 kJ/mol, para as culturas sem e com adaptação, respectivamente, com temperaturas entre 25-35ºC. Esse mecanismo de lixiviação foi corroborado por identificação fásica XR D e em estudos da resídua da lixiviação.

  18. Hotel (Hotel star rating) upgrading Project Method and Model --Case study: Fujian MinJiang Hotel upgrading Project%酒店升星改造的设计方法与模式——以福建省闽江饭店升星改造工程为例

    何嘉

    2012-01-01

    Hotel (hotel star rating) upgrading is a systematic project, including comprehensive planning, novel style, aesthetic ap- pearance, technical support and professional management, etc. The implementation process is a systematic investigation, rational analysis, found the problem and problem solving process. The designer explored and analysed the method and model of hotel up grading and interior design through his experience in Hotel upgrading project of FuJian MinJiang Hotel and delivered the concept in this article.%酒店升星改造是一项系统工程,包括全面的规划,新颖的风格,审美的表象,配套的技术和专业的管理等。实施过程是一个系统的调查研究,理性分析,发现问题,解决问题的过程。本文通过对自己设计的福建省闽江饭店升星改造工程这一实际案例的分析,探寻酒店升星改造的室内设计方法与模式。

  19. Impact of Mineralogy and Diagenesis on Reservoir Quality of the Lower Cretaceous Upper Mannville Formation (Alberta, Canada Impact de la minéralogie et de la diagenèse sur la qualité des réservoirs de la Formation Mannville Supérieur, Crétacé Inférieur (Alberta, Canada

    Deschamps R.

    2012-02-01

    space where the clay content is reduced. Additional SEM and XRD analyses allowed characterizing and quantifying more accurately the different mineralogical phases occluding the porous network. The characterization of both mineralogy and petrophysical properties gives useful keys to locate the diagenetic phases laterally and vertically, and to predict the petrophysical properties distribution. La Formation Mannville Supérieur du Crétacé Inférieur d’Ouest-Central Alberta a été intensivement forée les précédentes décennies par des puits visant des réservoirs plus profonds. Cependant, les données de production dans ce secteur suggèrent que des volumes significatifs de gaz soient présents dans les réservoirs tant conventionnels que non conventionnels (“tight reservoirs” de cette formation. Les réservoirs de la Formation Mannville Supérieur d’Ouest-Central Alberta sont constitués de grès fluviatiles remplissant des vallées incisées. Ces grès présentent une minéralogie complexe, avec des quantités variables de quartz, de feldspaths, de minéraux argileux et des fragments de roche. Ils ont été soumis à une histoire diagénétique complexe et la paragenèse qui en résulte a eu un impact sur leurs propriétés réservoirs. Par conséquent, les hétérogénéités dans les propriétés réservoirs induisent des risques significatifs en termes d’exploration et de production de ces réservoirs. Nous présentons dans cet article les résultats de l’étude diagénétique, effectuée dans un cadre stratigraphique bien contraint, visant à comprendre l’impact de la minéralogie et de la diagenèse sur l’évolution de la qualité des réservoirs. Soixante et onze échantillons prélevés sur huit puits ont permis de réaliser une analyse pétrographique et proposer une séquence paragénétique. Quatre événements diagénétiques principaux ont été identifiés et sont liés à l’enfouissement du bassin : – coating d’argile autour des

  20. Future Recovery of Energy and Mineral Values from Organic-Rich Shales (Summary L'avenir de la production d'énergie et de la valeur minérale des schistes riches en matière organique (résumé

    Park W. C.

    2006-10-01

    Full Text Available Oil shale deposits vary significantly in their geological nature and can represent enormous reserves of low grades ores for various minerals such as alumina, sodium carbonates, molybdenum, nickel, vanadium, and uranium. The treatment of these rocks for mineral values can be economically attractive when coupled with the production of synthetic oil. Mutually shared costs for extractinq the mineral values can be favorably affected by utilizing by-products from the oil shale retorting. These can include the residual char for a carbonaceous reductant or fuel, C02 for acidification, or lime and soda ash for caustic. Conversely, an inappropriate choice of oil shale retorting conditions can substantially lower subsequent recovery of mineral values from the spent shale. The proceeding considerations will be discussed for several oil shale deposits including: 1. The Green River formation in the mid-western United States which is not only oil rich but also represents a nearly inexhaustible domestic supply of alumina and sodium carbonates and 2. The block shale of Julia Creek, Queensland, Australia, the Devonian Chattanooga shale in the United States, the Cambrian Kulm shale in Sweden, the Permian Lodeve shale in southern France, and the Paleozoic shales from Korea and USSR for energy and metal values such as molybdenum, nickel, vanadium, and uranium. La nature géologique des dépôts de schistes à huile est très variée ; ces schistes peuvent représenter des réserves énormes de minerais à faible teneur de métaux tels que l'aluminium, le molybdène, le nickel, le vanadium, l'uranium, sans oublier le carbonate de sodium. Le traitement de ces roches pour leur valeur minérale peut être attractif économiquement s'il est associé à la production d'huile synthétique. La répartition des coûts d'extraction des métaux peut être favorablement affectée en utilisant les sous-produits du traitement des schistes à huile. Ceci peut comprendre le goudron

  1. Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype.

    Antognelli, Cinzia; Gambelunghe, Angela; Muzi, Giacomo; Talesa, Vincenzo Nicola

    2016-03-01

    Glyoxalase I (Glo1) is the main scavenging enzyme of methylglyoxal (MG), a potent precursor of advanced glycation end products (AGEs). AGEs are known to control multiple biological processes, including epithelial to mesenchymal transition (EMT), a multistep phenomenon associated with cell transformation, playing a major role in a variety of diseases, including cancer. Crystalline silica is a well-known occupational health hazard, responsible for a great number of human pulmonary diseases, such as silicosis. There is still much debate concerning the carcinogenic role of crystalline silica, mainly due to the lack of a causal demonstration between silica exposure and carcinogenesis. It has been suggested that EMT might play a role in crystalline silica-induced lung neoplastic transformation. The aim of this study was to investigate whether, and by means of which mechanism, the antiglycation defence Glo1 is involved in Min-U-Sil 5 (MS5) crystalline silica-induced EMT in BEAS-2B human bronchial epithelial cells chronically exposed, and whether this is associated with the beginning of a neoplastic-like transformation process. By using gene silencing/overexpression and scavenging/inhibitory agents, we demonstrated that MS5 induced hydrogen peroxide-mediated c-Jun-dependent Glo1 up-regulation which resulted in a decrease in the Argpyrimidine-modified Hsp70 protein level which triggered EMT in a novel mechanism involving miR-21 and SMAD signalling. The observed EMT was associated with a neoplastic-like phenotype. The results obtained provide a causal in vitro demonstration of the MS5 pro-carcinogenic transforming role and more importantly they provide new insights into the mechanisms involved in this process, thus opening new paths in research concerning the in vivo study of the carcinogenic potential of crystalline silica. PMID:26784015

  2. Petrophysical and Mineralogical Research on the Influence of CO2 Injection on Mesozoic Reservoir and Caprocks from the Polish Lowlands Études pétrographique et minéralogique de l’impact de l’injection de CO2 dans les roches réservoirs de la Basse Plaine de Pologne

    Tarkowski R.

    2011-03-01

    Full Text Available Special equipment, simulating formation conditions, was designed to study interactions between injected CO2, rocks and brines. The investigations were carried out on samples collected from reservoir and caprocks of the Pagórki (Cretaceous deposits and Brześć Kujawski (Jurassic deposits boreholes. Mineralogical and petrographic investigations were carried out on the samples before and after the experiment to determine changes occurring as a result of the processes. The investigations proved that these rocks show good quality reservoir and sealing properties. The experiment did not significantly worsen the reservoir properties of the rocks. Afin de mener des recherches sur l’impact CO2 – roche – saumures, nous avons développé un modèle de simulation des conditions de gisement, pour lesquelles l’injection de dioxyde de carbone est envisagée. Des analyses ont été effectuées sur des échantillons de carotte de roche provenant des réservoirs et de la couverture, prélevés dans les forages de Pagórki (formations du Crétacé et de Brześć Kujawski (formations du Jurassique. Ces échantillons ont été soumis, avant et après les expériences, à des analyses pétrographiques et minéralogiques classiques, afin de déterminer les variations induites par les expériences. Les études menées ont montré que les réservoirs possèdent de bonnes propriétés de stockage de CO2, et les roches de couverture de bonnes propriétés d’étanchéité. L’expérimentation réalisée ne montre pas d’impact notable du gaz injecté sur les propriétés des roches réservoir analysées.

  3. Géochimie minérale de sédiments à faciès black-shales, Crétacé moyen de l'Atlantique Nord, sites DSDP 386 et 391 Mineral Geochemistry of Black Shales from the Mid-Cretaceous of the North Atlantic, Dsdp Sites 386 and 391

    Brosse E.

    2006-11-01

    Full Text Available L'analyse chimique de 154 échantillons d'âge Aptien à Turonien, pour l'essentiel des argilites, en provenance des sites DSDP-IPOD 386 (situé sur la ride des Bermudes et 391 (localisé au pied de la marge américaine, met en évidence, d'une manière indépendante des lithofaciès et des compositions minéralogiques, un certain nombre d'influences enregistrées par les sédiments : - influences du potentiel d'oxydo-réduction : enrichissements en Fe et Mn des dépôts oxydés ; en V, Ni, Co, Zn, Cu des sédiments réduits, et notamment des argilites pyriteuses et très carbonées déposées pendant l'événement E2à la limite Cénomanien-Turonien ; - influences du détritisme terrigène, avec trois indices particulièrement intéressants : les comportements comparés des alcalins (Na et K, la teneur en Ga des smectites, et le rapport D = AI/(AI + Fe + Mn ; - influences du volcanisme, soit sous forme de pyroclastes (enrichissement en Ti et Cr, soit sous forme ionique par l'intermédiaire de solutions interstitielles circulantes (enrichissement en Fe, Mn, Ba, Ni, Co, Cu, Pb ; - influence du taux de sédimentation, mise en évidence grâce à Cr. Les résultats obtenus apportent des précisions intéressantes sur l'évolution dans l'espace et dans le temps des milieux de dépôt et de diagenèse. Etant donné, par ailleurs, que les sédiments étudiés se sont déposés dans des conditions de milieux déjà connues grâce aux approches de la sédimentologie, de la minéralogie et de la géochimie organique, la reconnaissance des caractéristiques géochimiques de tels milieux pourra probablement aider à la reconstitution des conditions de dépôt pour des séries d'âges et de faciès comparables, mais transformées par un métamorphisme isochimique, telles les schistes lustrés alpins. One hundred fifty-four samples of Aptian to Turonian black-shales from various lithofacies have been selected for chemical analysis from DSDP sites 386

  4. Determination of the kQclin,Qmsrfclin,fmsr correction factors for detectors used with an 800 MU/min CyberKnife® system equipped with fixed collimators and a study of detector response to small photon beams using a Monte Carlo method

    Purpose: In a previous work, output ratio (ORdet) measurements were performed for the 800 MU/min CyberKnife® at the Oscar Lambret Center (COL, France) using several commercially available detectors as well as using two passive dosimeters (EBT2 radiochromic film and micro-LiF TLD-700). The primary aim of the present work was to determine by Monte Carlo calculations the output factor in water (OFMC,w) and the kQclin,Qmsrfclin,fmsr correction factors. The secondary aim was to study the detector response in small beams using Monte Carlo simulation. Methods: The LINAC head of the CyberKnife® was modeled using the PENELOPE Monte Carlo code system. The primary electron beam was modeled using a monoenergetic source with a radial gaussian distribution. The model was adjusted by comparisons between calculated and measured lateral profiles and tissue-phantom ratios obtained with the largest field. In addition, the PTW 60016 and 60017 diodes, PTW 60003 diamond, and micro-LiF were modeled. Output ratios with modeled detectors (ORMC,det) and OFMC,w were calculated and compared to measurements, in order to validate the model for smallest fields and to calculate kQclin,Qmsrfclin,fmsr correction factors, respectively. For the study of the influence of detector characteristics on their response in small beams; first, the impact of the atomic composition and the mass density of silicon, LiF, and diamond materials were investigated; second, the material, the volume averaging, and the coating effects of detecting material on the detector responses were estimated. Finally, the influence of the size of silicon chip on diode response was investigated. Results: Looking at measurement ratios (uncorrected output factors) compared to the OFMC,w, the PTW 60016, 60017 and Sun Nuclear EDGE diodes systematically over-responded (about +6% for the 5 mm field), whereas the PTW 31014 Pinpoint chamber systematically under-responded (about −12% for the 5 mm field). ORdet measured with the SFD diode

  5. Raypex® 5’in Minör Çapın Belirlenmesindeki Doğruluğunun Ex Vivo Olarak Değerlendirilmesi Ex Vivo Evaluation Of The Accuracy Of Raypex® 5 In Determining The Minor Diameter

    Nevin Kartal

    2011-05-01

    Full Text Available

    ÖZET

    Amaç: Bu ex vivo çalışmanın amacı, Raypex® 5 adlı elektronik apeks bulucunun minör çapın tespitindeki doğruluğunu değerlendirmektir.

    Gereç ve Yöntem: Çalışmada 40 adet çekilmiş üst kesici insan dişi kullanıldı. Operasyon mikroskobu altında X5 büyütmede eğe ucu, majör foramene kadar ilerletildi ve silikon stoper düzleştirilmiş koronal yüzeyde sabitlendi. Silikon stoper ve eğe ucu arasındaki mesafe ölçüldü ve referans kanal boyu (RKB olarak adlandırıldı. Daha sonra Raypex® 5 ile elektronik ölçümler alındı ve silikon stoperle eğe ucu arasındaki mesafe ölçülerek bu değer elektronik kanal boyu (EKB olarak adlandırıldı. Ardından kanal aleti, RKB’de akışkan kompozitle dişin koronalinde sabitlendi. Kök kanallarının apikal 4 mm’leri elmas frezlerle ekspoze edildikten sonra X64 büyütmede stereomikroskop altında incelendi ve dijital fotoğrafları alındı. Tüm görüntüler

  6. 海口闽语量词“目”“节”“xak5”理据与用法浅析--兼论与琼地少数民族语言、现代汉语比较%An Analysis of the Motivation and Usage of Qualifiers“Mu”,“Jie”,“xak5”in Min Dialect in Haikou

    李清桓; 邹岚

    2015-01-01

    The qualifiers “mu”,“jie”,“xak5”in Min dialect in Haikou are used to measure the length of segments or things,but the motivations and usages of each are different.“Mu”is the qualifier in Min dialect used to describe the characteristics of things.With the influence of the qualifier “jie”,it is motivated by the metaphoric mechanism and the law of parallel-derived words,used to measure things with knurs,and its length is integral multiple of “knur”;while “j ie”is used to measure things with relatively definite length measurement;and“xak5”originates from the Dong-Tai language family and the conversion of verbs with the corresponding “segment”meaning,which is used to measure things with any length.%海口闽语量词“目”、“节”、“xak5”能用来计量分段物或事物的长度,但三者产生的理据和用法各有不同。“目”是闽语特征量词,产生的理据是在“节”的影响下通过隐喻机制和词汇平行衍生规律的促动而形成,用来计量具有“结节”之物,且长度是“结节”的整数倍;“节”则用来计量长度相对确定的事物;“xak5”是借自侗台语族的量词,由侗台语族相应的、具有“断”语义的动词转类而成,用来计量任意长短的事物。

  7. Comparison of Pulmonary function parameters changes at different altitudes (1150m and 4150min healthy athletes

    Alizadeh R

    2007-04-01

    Full Text Available Background: Both hypoxia and hypocapnia can cause broncho-constriction in humans, and this could have a bearing on performance at high altitude. The objective of this study was to examine how pulmonary ventilatory function during high-altitude trekking. Methods: This study was a before and after study on spirometric parameters at Base line (1150 m above sea level, and after ascending at 4150 m above sea level. This study was performed in summer 2004 at Cialan Mountain in Iran. Fifty six healthy male University student volunteers were enrolled in the study. Respiratory function was assessed in participants before ascending at baseline (1150 meter and after ascending at 4150 meter in Cialan Mount with a Spirolab II. Spirometric parameters changes were compared using paired t-test statistical analysis computations were performed by spss 11.5 and p≤0.05 was considered significant. Results: The mean age and body mass lindex of our subjects were 22.9±5.3 years and 21.5±2.5, respectively. Forced vital capacity (FVC was significantly decreased with increasing altitude from baseline level (P0.05. FVC fell by the average of 7.1% at 4150m (2.4% per 1000m increased altitude in comparison to 1150m. Conclusion: The changes in some pulmonary ventilatory parameters were proportional to the magnitude of change in altitude during a high-altitude trek.

  8. Markt van min en meer: recente publicaties op het terrein van de godsdienstpsychologie

    J.A. van Belzen

    2012-01-01

    The author presents a number of recent publications in the field of the psychology of religion. The very diverse monographs are categorized as: Introductions, overviews, teaching materials; Psychohistory, especially as applied to the study of the so-called ‘New Testament’; Religious terrorism; Mysti

  9. Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

    Fatehullah, A; Sharma, S; Newton, I P; Langlands, A J; Lay, H; Nelson, S A; McMahon, R K; McIlvenny, N; Appleton, P L; Cochran, S; Näthke, I S

    2016-01-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic. PMID:27406832

  10. Effects of Recovery using Contrast Water Therapy or Compression Stockings on Subsequent 5-min Cycling Performance

    Arnaud Ménétrier; Julien Pinot; Laurent Mourot; Frédéric Grappe; Malika Bouhaddi; Jacques Regnard; Nicolas Tordi

    2013-01-01

    Many researchers have investigated the effectiveness of contrast water therapy (CWT) or compression stockings (CS) during recovery, using subsequent performance as the principal outcome measure. However, data in the literature are contradictory, mainly because of the methodology used. Purpose: Based on well-controlled performance measures, this study aimed to compare the effects of CWT, CS or passive recovery (PR) on subsequent performance. Methods: After inclusion based on reproducibility cr...

  11. Min-On Art Group’s Performance Tour Of Beijing and Tianjin

    Yu; Wen

    2014-01-01

    <正>A performance of songs and dances with conspicuous Japanese national features was staged at Beijing Mei Lanfang Grand Theatre last fall.The gorgeous and passionate performance helped the audience experience a great joy as if they had seen the cherry blossom in spring and good harvest in autumn.The music played by a performer rapidly plucking at the Tsugaru Shamisen,a traditional stringed

  12. Serpine1 Mediates Porphyromonas gingivalis Induced Insulin Secretion in the Pancreatic Beta Cell Line MIN6

    Bhat, Uppoor G.; Watanabe, Keiko

    2015-01-01

    Periodontitis is an inflammatory disease resulting in destruction of gingiva and alveolar bone caused by an exuberant host immunological response to periodontal pathogens. Results from a number of epidemiological studies indicate a close association between diabetes and periodontitis. Results from cross-sectional studies indicate that subjects with periodontitis have a higher odds ratio of developing insulin resistance (IR). However, the mechanisms by which periodontitis influences the develo...

  13. An Exact Solution to the Power Networks Security Index Problem and its Generalized Min Cut Formulation

    Hendrickx, Julien; Jungers, Raphael; Sandberg, Henrik; Sou, Kin Cheong

    2012-01-01

    The resilience of Supervisory Control and Data Acquisition (SCADA) systems for electric power networks for certain cyber-attacks is considered. In particular, we study the robustness of the observability properties of the network to the loss of some measurements. It was recently shown, under the full measurement assumption, that the problem can be cast as a generalization of the minimum cut problem involving costly nodes. In this paper, we show that it can be reformulated as a standard minimum cut problem (without costly nodes) on a modified graph of proportional size. An important consequence of this result is that the observability problem can be solved efficiently. Our approach provides the first exact efficient algorithm for this problem. It is illustrated on a numerical example.

  14. A propos de quelques lettres de Lavoisier sur la minéralogie

    Gohau, Gabriel

    1984-01-01

    J'ai eu récemment entre les mains, en vue d'en déterminer l'intérêt géologique, quelques lettres inédites de Antoine Laurent de Lavoisier, datant du début de l'année 1785, et qui paraîtront dans la correspondance,actuellement en cours de publication, de l'illustre chimiste. Sans vouloir déflorer cette correspondance avant parution, je m'efforcerai d'en souligner la valeur, en la replaçant dans l'oeuvre géologique de LAVOISIER. Je remercie Mme Michelle Goupil qui m'a donné accès à ces lettres....

  15. Deterministic separation of cancer cells from blood at 10 mL/min

    Kevin Loutherback; Joseph D'Silva; Liyu Liu; Amy Wu; Austin, Robert H.; Sturm, James C.

    2012-01-01

    Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters of cancer cells with their associated stroma cells...

  16. MODIS/AQUA MYD14 Thermal Anomalies & Fire 5-Min L2 Swath 1km

    U.S. Geological Survey, Department of the Interior — MODIS Thermal Anomalies/Fire products are primarily derived from MODIS 4- and 11-micrometer radiances. The fire detection strategy is based on absolute detection of...

  17. Modern large 3000 rev/min steam turbines for pressurized water reactor power stations

    The general thermodynamic cycle requirements applying to modern 3000 rpm steam turbines for pressurised water reactor power stations are reviewed. Consideration is given to factors affecting thermal efficiency, including the optimisation of cycle parameters and the use of moisture separation and steam reheating. Principles of mechanical design, based on a modular design concept for turbine cylinders, are discussed with reference to a range of 3000 rpm turbines with outputs up to 1300 MW. The most recent developments, involving machines of 630 MW and 985 MW output currently under construction, are described. The importance of service experience with nuclear steam turbines associated with a variety of types of water cooled reactor is emphasized, and its relevance to the design of modern 3000 rpm turbines for pressurised water reactor applications discussed. (author)

  18. A Uniform Min-Max Theorem and Characterizations of Computational Randomness

    Zheng, Jia

    2014-01-01

    This thesis develops several tools and techniques using ideas from information theory, optimization, and online learning, and applies them to a number of highly related fundamental problems in complexity theory, pseudorandomness theory, and cryptography.

  19. Increased variability in ApcMin/+ intestinal tissue can be measured with microultrasound

    Fatehullah, A.; Sharma, S.; Newton, I. P.; Langlands, A. J.; Lay, H.; Nelson, S. A.; McMahon, R. K.; McIlvenny, N.; Appleton, P. L.; Cochran, S.; Näthke, I. S.

    2016-07-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic.

  20. 7.5min Quadrangle Index for Acadia National Park (index24.shp)

    National Park Service, Department of the Interior — INDEX24 contains 1:24,000 scale neatlines for USGS 7.5 minute quadrangle maps covering Acadia National Park's GIS project area in Maine. The index was originally...

  1. Dobbelary: Om van baie verloorders te maak en van min wenners?

    D. P. Veldsman

    1993-08-01

    Full Text Available Gambling: Making losers of many and winners of few?The question of the desirability of legalising gambling in South Africa and the affirmative proposal by the Howard Commission Report (March 1993 to this extent, is critically addressed in this short paper. Gambling, being a game of chance - and certainly already a well established and favourite pastime in South Africa - invites an understanding of the element of chance.

  2. Measurement of utero-placental blood flow with /sup 113m/In in diabetic pregnancy

    Semmler, K.; Kirsch, G.; Zoellner, P.; Fuhrmann, K.; Jutzi, E. (Zentralinstitut fuer Diabetes, Karlsburg (German Democratic Republic); Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik)

    1985-01-01

    In 122 diabetic pregnancies the placental blood flow has been estimated determining the half-life of the activity inflow (2 MBq /sup 113m/In-transferrin) into the placenta. A highly sensitive detector (modified pinhole collimator) and a computer-supported evaluation were used. 259 flow measurements were compared to the risk of complication in the course of diabetic pregnancy. The half-life values in the diabetic group, calculated by a gamma camera computer system by means of an iterative regression analysis, were significantly different compared to a control group (12 pregnancies without risk.) Severe diabetic angiopathic complications (classes D, F, and R according to White) are accompanied by higher half-life values (placental blood flow reductions) and perinatal complications. Even in pregnant women with gestational diabetes of disturbances of the carbohydrate metabolism disturbed placental hemodynamics is to be found.

  3. Effect of slow deep breathing (6 breaths/min) on pulmonary function in healthy volunteers

    Shravya Keerthi G, Hari Krishna Bandi, Suresh M, Mallikarjuna Reddy N

    2013-01-01

    We designed this study to test the hypothesis that whether 10 minutes of slow deep breathing have any effect on pulmonary function in healthy volunteers. The main objective was to study the immediate effect of slow deep breathing on Forced vital capacity (FVC), Forced expiratory volume in the first second (FEV1), Forced expiratory volume percent (FEV1/FVC%), Peak expiratory flow rate (PEFR), Forced expiratory flow 25-75%(FEF25-75%), Maximum voluntary ventilation (MVV), Slow vital capacity (SV...

  4. RoadRunner for Heterogeneous Web Pages Using Extended MinHash

    A Suresh Babu

    2012-03-01

    Full Text Available The Internet presents large amount of useful information which is usually formatted for its users, which makes it hard to extract relevant data from diverse sources. Therefore, there is a significant need of robust, flexible Information Extraction (IE systems that transform the web pages into program friendly structures such as a relational database will become essential. IE produces structured data ready for post processing. Roadrunner will be used to extract information from template web pages. In this paper, we present novel algorithm for extracting templates from a large number of web documents which are generated from heterogeneous templates. The proposed system focuses on information extraction from heterogeneous web pages. We cluster the web documents based on the common template structures so that the template for each cluster is extracted simultaneously. The resultant clusters will be given as input to the Roadrunner system.

  5. MODIS/TERRA MOD14 Thermal Anomalies & Fire 5-Min L2 Swath 1km

    U.S. Geological Survey, Department of the Interior — MODIS Thermal Anomalies/Fire products are primarily derived from MODIS 4- and 11-micrometer radiances. The fire detection strategy is based on absolute detection of...

  6. GeMInA, Genomic Metadata for Infectious Agents, a geospatial surveillance pathogen database

    Schriml, Lynn M.; Arze, Cesar; Nadendla, Suvarna; Ganapathy, Anu; Felix, Victor; Mahurkar, Anup; Phillippy, Katherine; Gussman, Aaron; Angiuoli, Sam; Ghedin, Elodie; White, Owen; Hall, Neil

    2009-01-01

    The Gemina system (http://gemina.igs.umaryland.edu) identifies, standardizes and integrates the outbreak metadata for the breadth of NIAID category A–C viral and bacterial pathogens, thereby providing an investigative and surveillance tool describing the Who [Host], What [Disease, Symptom], When [Date], Where [Location] and How [Pathogen, Environmental Source, Reservoir, Transmission Method] for each pathogen. The Gemina database will provide a greater understanding of the interactions of vir...

  7. MODIS/Terra Geolocation Fields 5-Min L1A Swath 1km V005

    National Aeronautics and Space Administration — Geolocation collection contains geodetic latitude and longitude, surface height above geoid, solar zenith and azimuth angles, satellite zenith and azimuth angles,...

  8. MODIS/Terra Raw Radiances in Counts 5-Min L1A Swath V005

    National Aeronautics and Space Administration — Level 1A collection contains digitized raw detector counts for the 36 MODIS spectral bands as well as engineering and spacecraft ancillary data. Only bands 20 to 36...

  9. Min-Max Latency Walks: Approximation Algorithms for Monitoring Vertex-Weighted Graphs

    Alamdari, Soroush; Smith, Stephen L

    2012-01-01

    In this paper we consider the problem of planning a path for a robot to monitor a known set of features of interest in an environment. We represent the environment as a vertex- and edge-weighted graph, where vertices represent features or regions of interest. The edge weights give travel times between regions, and the vertex weights give the importance of each region. If the robot repeatedly performs a closed walk on the graph, then we can define the latency of a vertex to be the maximum time between visits to that vertex, weighted by the importance (vertex weight) of that vertex. Our goal in this paper is to find the closed walk that minimizes the maximum weighted latency of any vertex. We show that there does not always exist an optimal walk of polynomial size. We then prove that for any graph there exist a constant approximation walk of size O(n^2), where n is the number of vertices. We provide two approximation algorithms; an O(log n)-approximation and an O(log \\rho)-approximation, where \\rho is the ratio...

  10. The MinAdept Clustering Approach for Discovering Reference Process Models out of Process Variants

    Li, Chen; Reichert, Manfred; Wombacher, Andreas

    2010-01-01

    During the last years a new generation of adaptive Process-Aware Information Systems (PAIS) has emerged, which enables dynamic process changes at runtime, while preserving PAIS robustness and consistency. Such adaptive PAIS allow authorized users to add new process activities, to delete existing act

  11. A min-type stochastic fixed-point equation related to the smoothing transformation

    Alsmeyer, Gerold; Meiners, Matthias

    2009-01-01

    This paper is devoted to the study of the stochastic fixed-point equation X \\stackrel{d}{=} \\inf_{i \\geq 1: T_i > 0} X_i/T_i and the connection with its additive counterpart $X \\stackrel{d}{=} \\sum_{i\\ge 1}T_{i}X_{i}$ associated with the smoothing transformation. Here $\\stackrel{d}{=}$ means equality in distribution, $T := (T_i)_{i \\geq 1}$ is a given sequence of nonnegative random variables and $X, X_1, ...$ is a sequence of nonnegative i.i.d. random variables independent of $T$. We draw att...

  12. Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis.

    Urbanska, Aleksandra Malgorzata; Bhathena, Jasmine; Cherif, Sofiane; Prakash, Satya

    2016-01-01

    The development of intestinal polyps in an orthotopic colorectal mouse model, receiving a probiotic yogurt formulation containing microencapsulated live Lactobacillus acidophilus cells was investigated. The expression of various immunohistochemical markers namely CD8, Mac-1, Ki-67, and cleaved caspase-3, was evaluated. Results suggest that the probiotic formulation decreases overall intestinal inflammation. Mice receiving the probiotic formulation were found to develop almost two-fold fewer tumors in the small intestines. In the large intestine, however, there was no significant difference observed among polyp numbers. The formulation appears to have potential application in the prevention of various GI pathological conditions. PMID:25060720

  13. Increased variability in ApcMin/+ intestinal tissue can be measured with microultrasound

    Fatehullah, A.; Sharma, S.; Newton, I. P.; Langlands, A. J.; Lay, H.; Nelson, S. A.; McMahon, R. K.; McIlvenny, N.; Appleton, P. L.; Cochran, S.; Näthke, I. S.

    2016-01-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic. PMID:27406832

  14. Hukm Naql A'da'i Mahdur al-Dam min Manzur Islami

    Ahmad Al-Suwaehi Syulaibek

    2012-10-01

    Full Text Available This research deals with an important issue, namely: (provisions of transferring organs of executed, it has been divided to: introduction, preface, and three section: The Researcher discuss in the preface: the concept of transfer of human organs, showed the meaning of transportation, the organ, and the meaning of organ transplants. The concept of the executed, its types, showed the meaning of shed, and the executed, and its types. And search in second section: transfer organs of a living person to another, showed the rule of transferring individual organ, and organs of non-individual. An  discussed in the third section: Transfer of organs of the executed to another human being, showed the rule of eating the executed when necessary, and the rule of transferring of organs of the executed, and the rule of reconciliation of the executed on the transfer of its organs in exchange for not killing him, starting the opinions of jurists and their evidence, and discuss the evidence and weighting between opinions. The Researcher concluded that it is permissible to transfer organs of the executed and put it in an human body protected blood near death, under certain conditions to be met, and it is permissible to reconcile the infidel military and spy to waive for not killing him.

  15. Ariab acidic min-influenced water: a waste to waste treatment

    Six samples of acidic mine-influenced water (AMIW) from Ariab area, Red Sea Hills, northeastern part of Sudan, were analyzed for some waste water parameters. The investigation showed that, the pH ranged between 1.30 to 1.88, sulphate content between 40200 to 235300 mg/1, total iron 9879 to 103969 mg/1, copper, 280.0 to 1112.5 mg/1, zinc, 1825 to 3345 mg/1, manganese, 210.0 to 570.0 mg /1 in addition to high contents of cobalt and cadmium which are known for their negative impact on the environment. Khartoum Refinery Sour Water (KRSW) sample was analyzed for some pollutants, the analysis showed that it is alkaline industrial waste having a pH of 10.10, alkalinity of 26381 mg/1 as CaC3/1, Chemical Oxygen Demand (COD) of 29400 mg/1 as O2. It was found to be relatively free of heavy and environmentally hazardous elements such as Fe, Co, Ca, Cd, Cu, Zn, Mn, Pb and Mg. A waste to waste treatment was carried to Ariab AMIW with KRSW, satisfactory results were obtained in reduction of the parameters studied in the treated effluent. The pH of AMIW was raised to about 8.50, and the element contents of Fe, Co, Ca, Cd, Cu, Zn, Mn, Pb were either completely removed or reduced to levels that meet the allowed limits of the industrial effluent disposal threshold. Sulphate content, however, decreased due to dilution, but still above the specified limits of the effluent disposal. (Author)

  16. Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression

    Galli, G G; Multhaupt, H A; Carrara, M;

    2013-01-01

    PRDM proteins are tissue-specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high ...... PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.Oncogene advance online publication, 22 July 2013; doi:10.1038/onc.2013.283....

  17. Muscle Synergies of Untrained Subjects during 6 min Maximal Rowing on Slides and Fixed Ergometer

    Shazlin Shaharudin

    2014-12-01

    Full Text Available The slides ergometer (SE was an improvisation from fixed ergometer (FE to bridge the gap of mechanics between ergometer rowing and on-water rowing. The specific mechanical constraints of these two types of ergometers may affect the pattern of muscle recruitment, coordination and adaptation. The main purpose of this study was to evaluate the muscle synergy during 6 minutes maximal rowing on slides (SE and fixed ergometers (FE. The laterality of muscle synergy was also examined. Surface electromyography activity, power output, heart rate, stroke length and stroke rate were analyzed from nine physically active subjects to assess the rowing performance. Physically active subjects, who were not specifically trained in rowing, were chosen to exclude the training effect on muscle synergy. Principal component analysis (PCA with varimax rotation was applied to extract muscle synergy. Three muscle synergies were sufficient to explain the majority of variance in SE (94.4 ± 2.2 % and FE (92.8 ± 1.7 %. Subjects covered more rowing distance, exerted greater power output and attained higher maximal heart rate during rowing on SE than on FE. The results proved the flexibility of muscle synergy to adapt to the mechanical constraints. Rowing on SE emphasized on bi-articular muscles contrary to rowing on FE which relied on cumulative effect of trunk and upper limb muscles during propulsive phase.

  18. Muscle Synergies of Untrained Subjects during 6 min Maximal Rowing on Slides and Fixed Ergometer

    Shaharudin, Shazlin; Zanotto, Damiano; Agrawal, Sunil

    2014-01-01

    The slides ergometer (SE) was an improvisation from fixed ergometer (FE) to bridge the gap of mechanics between ergometer rowing and on-water rowing. The specific mechanical constraints of these two types of ergometers may affect the pattern of muscle recruitment, coordination and adaptation. The main purpose of this study was to evaluate the muscle synergy during 6 minutes maximal rowing on slides (SE) and fixed ergometers (FE). The laterality of muscle synergy was also examined. Surface ele...

  19. Minä olen Raunio : Konseptisuunnittelua Raunio -brändille

    Määttä, Tiia

    2015-01-01

    Opinnäytetyön aiheena oli luoda konsepti vaatetusalan yritykselle. Tekijä pohjusti työn teorian oppimaansa, sekä tutki yrityksen perustamiseen, design managementiin, brändäykseen ja muotoiluprosessiin liittyvää kirjallisuutta sisällöllisenanalyysin avulla. Työssä edettiin Ilkka Kettusen (2013) iteratiivisen muotoiluprosessin mukaisesti. Yritykselle luotiin design managementin mukainen yrityskuva, joka toimi konseptin perustana. Design managementin ja brändäyksen teoriaa tutkitt...

  20. Jaapani professor esines Tallinna Tehnikaülikoolis / Mart Min, Enn Velmre

    Min, Mart, 1943-

    2001-01-01

    Külas oli Tohoku Ülikooli prorektor ja biomeditsiinielektroonika labori juhataja Nozomu Hoshimiya, kes pidas loengu halvatud inimeste liigutamisvõime osalisest taastamisest lihaste neuromuskulaarse juhtimise abil elektrilise stimulatsiooni abil

  1. Muscle Synergies of Untrained Subjects during 6 min Maximal Rowing on Slides and Fixed Ergometer.

    Shaharudin, Shazlin; Zanotto, Damiano; Agrawal, Sunil

    2014-12-01

    The slides ergometer (SE) was an improvisation from fixed ergometer (FE) to bridge the gap of mechanics between ergometer rowing and on-water rowing. The specific mechanical constraints of these two types of ergometers may affect the pattern of muscle recruitment, coordination and adaptation. The main purpose of this study was to evaluate the muscle synergy during 6 minutes maximal rowing on slides (SE) and fixed ergometers (FE). The laterality of muscle synergy was also examined. Surface electromyography activity, power output, heart rate, stroke length and stroke rate were analyzed from nine physically active subjects to assess the rowing performance. Physically active subjects, who were not specifically trained in rowing, were chosen to exclude the training effect on muscle synergy. Principal component analysis (PCA) with varimax rotation was applied to extract muscle synergy. Three muscle synergies were sufficient to explain the majority of variance in SE (94.4 ± 2.2 %) and FE (92.8 ± 1.7 %). Subjects covered more rowing distance, exerted greater power output and attained higher maximal heart rate during rowing on SE than on FE. The results proved the flexibility of muscle synergy to adapt to the mechanical constraints. Rowing on SE emphasized on bi-articular muscles contrary to rowing on FE which relied on cumulative effect of trunk and upper limb muscles during propulsive phase. Key pointsThree muscle synergies were extracted during maximal rowing on both fixed and slides ergometerUntrained subjects emphasized leg muscles while rowing on SEUntrained subjects focused on back muscles during FE rowing. PMID:25435771

  2. On the Quickest Flow Problem in Dynamic Networks - a Parametric Min-Cost Flow Approach

    Lin, Maokai; Jaillet, Patrick

    2015-01-01

    We consider the quickest flow problem in dynamic networks with a single source s and a single sink t: given an amount of flow F, find the minimum time needed to send it from s to t, and the corresponding optimal flow over time. We introduce new mathematical formulations and derive optimality conditions for the quickest flow problem. Based on the optimality conditions, we develop a new cost-scaling algorithm that leverages the parametric nature of the problem. The algorithm solves the quick...

  3. Measurement of utero-placental blood flow with /sup 113m/In in diabetic pregnancy

    In 122 diabetic pregnancies the placental blood flow has been estimated determining the half-life of the activity inflow (2 MBq /sup 113m/In-transferrin) into the placenta. A highly sensitive detector (modified pinhole collimator) and a computer-supported evaluation were used. 259 flow measurements were compared to the risk of complication in the course of diabetic pregnancy. The half-life values in the diabetic group, calculated by a gamma camera computer system by means of an iterative regression analysis, were significantly different compared to a control group (12 pregnancies without risk.) Severe diabetic angiopathic complications (classes D, F, and R according to White) are accompanied by higher half-life values (placental blood flow reductions) and perinatal complications. Even in pregnant women with gestational diabetes of disturbances of the carbohydrate metabolism disturbed placental hemodynamics is to be found. (author)

  4. The MinK Framework: Developing Metrics for the Measurement of Individual Knowledge

    Arisha, Amr; Ragab, Mohamed

    2013-01-01

    Knowledge is the currency of the current economy and a vital resource for the sustainability of performance quality in today’s knowledge intensive business environment. To avoid the detrimental consequences of knowledge loss, managers are urged to identify where knowledge stocks exist and how knowledge flows within their organisations by keying out wellsprings of knowledge among their employees. Although some studies have attempted to measure knowledge on an organisational level using differe...

  5. The robust min-max newsvendor problem with balking under a service level constraint

    Taesu Cheong

    2013-11-01

    Full Text Available In this paper we study an extension of a classic newsvendor model with balking under a service-level constraint. We also relax the assumption that the demand distribution is fully available to a decision-maker; we assume that only the mean and variance of the demand distribution are known, and discuss the procedure for determining the optimal order quantity for the concomitant model. We further extend our base model to two different cases: (i when the fixed ordering cost is included, and (ii when yield is uncertain. We illustrate the solution procedures for each case with numerical examples. Moreover, we discuss the performance and robustness of the approach through randomly generated test instances, and perform a numerical sensitivity analysis to evaluate the impact of the changes of a targeted fill-rate and variances of a demand distribution.

  6. Min-Max Design of FIR Digital Filters by Semidefinite Programming

    Nagahara, Masaaki

    2011-01-01

    In this article we consider two problems: FIR (Finite Impulse Response) approximation of IIR (Infinite Impulse Response) filters and inverse FIR filtering of FIR or IIR filters. By means of Kalman-Yakubovich-Popov (KYP) lemma and its generalization (GKYP), the problems are reduced to semidefinite programming described in linear matrix inequalities (LMIs). MATLAB codes for these design methods are given. An design example shows the effectiveness of these methods.

  7. Hvorfra min verden går:et Luhmann-inspireret bidrag til didaktikken

    Keiding, Tina Bering

    2005-01-01

    Afhandlingens problemformulering består af to spørgsmål. For det første hvordan cen-trale begreber for uddannelse og undervisning falder ud inden for rammerne af Niklas Luhmanns systemteori. For det andet hvordan disse begrebsafklaringer kan bidrage til udvikling af den teoretiske didaktik, herunder tematisering af spørgs-målet om, hvad der synes at udgøre centrale elementer i kommunikation, der har intentioner om at indvirke på og forandre andre systemer, samt spørgsmålet om, og i givet fald...

  8. Max-Flow Min-Cut Theorems for Multi-User Communication Networks

    Riis, Soren; Gadouleau, Maximilien

    2010-01-01

    The paper presents four distinct new ideas and results for communication networks: 1) We show that relay-networks (i.e. communication networks where different nodes use the same coding functions) can be used to model dynamic networks. 2) We introduce {\\em the term model}, which is a simple, graph-free symbolic approach to communication networks. 3) We state and prove variants of a theorem concerning the dispersion of information in single-receiver communications. 4) We show that the solvabili...

  9. Evolution of the Petrophysical and Mineralogical Properties of Two Reservoir Rocks Under Thermodynamic Conditions Relevant for CO2 Geological Storage at 3 km Depth Évolution des propriétés physiques et minéralogiques de deux roches réservoirs dans des conditions thermodynamiques correspondant à un stockage géologique de CO2 à 3 km de profondeur

    Rimmelé G.

    2009-11-01

    est considérée comme une solution pour contribuer à la réduction des émissions de gaz à effet de serre dans l’atmosphère. Les interactions entre le CO2 supercritique et la roche-réservoir potentielle doivent être étudiées en détail en conditions de stockage géologique. Quarante échantillons de calcaire de Lavoux et de grès d’Adamswiller, provenant de roches réservoirs du bassin parisien, ont été expérimentalement exposés au CO2 dans un autoclave spécialement construit pour reproduire les conditions thermodynamiques d’un réservoir de stockage de CO2. Les deux types de roches ont été exposés pendant un mois à du CO2 supercritique humide et à de l’eau saturée en CO2, à 28 MPa et 90 °C, ce qui correspond à des conditions d’enfouissement de 3 km de profondeur. L’évolution de leurs propriétés minéralogiques a été suivie par des analyses par diffraction des rayons X, par spectroscopie Raman et par microscopie électronique couplée à un système de microanalyses X. Leurs propriétés physiques et microtexturales ont été estimées en mesurant, avant et après les expériences, le poids, la densité, les propriétés mécaniques, la perméabilité, la porosité globale et la présence d’éventuels gradients de porosité de chaque échantillon. Les résultats montrent que les deux roches ont préservé leurs propriétés mécaniques et minéralogiques, malgré une augmentation de la porosité et de la perméabilité. Des zones microscopiques de dissolution de la calcite observées dans le calcaire sont vraisemblablement responsables de cette augmentation de la perméabilité et de la porosité. Dans le grès, une altération de la pétro-fabrique est supposée se produire due à la réaction des minéraux argileux avec le CO2. Tous les échantillons du calcaire de Lavoux et du grès d’Adamswiller ont montré une altération mesurable dans le CO2 humide et dans l’eau chargée en CO2. Ces expériences en autoclave sont

  10. Re-evaluation of microscopic and integral cross-section data for important dosimetry reactions. Re-evaluation of the excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P, 60Ni(n,p)60m+gCo, 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn, 127I(n,2n)126I, 197Au(n,2n)196Au and 199Hg(n,n')199mHg reactions

    Re-evaluations of cross sections and their associated covariance matrices have been carried out for ten dosimetry reactions: - excitation functions for the 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn and 199Hg(n,n')199mHg reactions were re-evaluated over the neutron energy range from threshold to 20 MeV; - excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P and 60Ni(n,p)60m+gCo were reevaluated in the energy range from threshold to 21 MeV; - excitation functions for the 127I(n,2n)126I and 197Au(n,2n)196Au reactions were reevaluated in the energy range from threshold to 32 and 40 MeV, respectively. Benchmark calculations performed for 235U thermal fission and 252Cf spontaneous fission neutron spectra show that the integral cross sections derived from the newly evaluated excitation functions exhibit improved agreement with related experimental data when compared with the equivalent data from the IRDF-2002 library. (author)

  11. Visit of Dr Stahl, Secretary of State, Federal Ministry for Education Science, Research and Technology, Germany, accompanied by MinDirig Dr Eschelbacher and MinR Dr Freytag

    Laurent Guiraud

    1998-01-01

    Visiting CERN on 19 January was Helmut Stahl, Secretary of State of the German Federal Ministry of Science, Education, Research and Technology (centre) seen here admiring prototype magnets for CERN's LHC proton collider with new President of CERN Council Hans Eschelbacher (right) and German delegate to CERN Council Arno Freytag. In the background is Dietrich Gusewell, Head of CERN's EST (Engineering Support and Technologies) Division.

  12. PREP KITT, System Reliability by Fault Tree Analysis. PREP, Min Path Set and Min Cut Set for Fault Tree Analysis, Monte-Carlo Method. KITT, Component and System Reliability Information from Kinetic Fault Tree Theory

    1 - Description of problem or function: The PREP/KITT computer program package obtains system reliability information from a system fault tree. The PREP program finds the minimal cut sets and/or the minimal path sets of the system fault tree. (A minimal cut set is a smallest set of components such that if all the components are simultaneously failed the system is failed. A minimal path set is a smallest set of components such that if all of the components are simultaneously functioning the system is functioning.) The KITT programs determine reliability information for the components of each minimal cut or path set, for each minimal cut or path set, and for the system. Exact, time-dependent reliability information is determined for each component and for each minimal cut set or path set. For the system, reliability results are obtained by upper bound approximations or by a bracketing procedure in which various upper and lower bounds may be obtained as close to one another as desired. The KITT programs can handle independent components which are non-repairable or which have a constant repair time. Any assortment of non-repairable components and components having constant repair times can be considered. Any inhibit conditions having constant probabilities of occurrence can be handled. The failure intensity of each component is assumed to be constant with respect to time. The KITT2 program can also handle components which during different time intervals, called phases, may have different reliability properties. 2 - Method of solution: The PREP program obtains minimal cut sets by either direct deterministic testing or by an efficient Monte Carlo algorithm. The minimal path sets are obtained using the Monte Carlo algorithm. The reliability information is obtained by the KITT programs from numerical solution of the simple integral balance equations of kinetic tree theory. 3 - Restrictions on the complexity of the problem: The PREP program will obtain the minimal cut and/or path sets for any tree with up to 2000 components and 2000 logical gates. All gates of the fault tree must be and and or gates, and no gate may have more than 7 inputs consisting of both components and other gates. PREP can obtain at most 1000 minimal cut sets with a maximum of 19 components per set, and can obtain at most 500 minimal path sets with a maximum of 29 components per set. KITT1 will obtain reliability information for up to 500 minimal cut or path sets containing a total of at most 400 distinct components and inhibit conditions. KITT2 will obtain reliability information for up to 500 minimal cut or path sets containing a total of at most 350 distinct components and inhibit conditions. KITT2 can obtain reliability information for each of 50 different phases per component

  13. Human albümin replasmanının karaciğer alıcılarında serum albümin düzeyine etkisi

    M, Uyar; C, Bor; L, Acar; K, Demirağ

    2013-01-01

    Amaç: Karaciğer transplant hastalarında düşük serum albumin düzeylerinin kötü prognoz belirtisi olduğu ve bu hastalarda erken postoperatif dönemde ciddi hipoalbüminemi gelişebileceği bildirilmiştir. Yoğun bakımımızda serum albumin düzeyi 3.0 g.dL-1 altında belirlenen karaciğer alıcılarına rutin olarak human albumin replasmanı uygulamaktadır. Çalışmamızın amacı karaciğer transplantasyonu uygulanan hastalarda postoperatif devrede uygulanan albumin replasmanı stratejisinin retrospektif olarak de...

  14. Variability of the MAX and MIN Statistic: A Theory of the Quantile Spread as a Function of Sample Size

    Townsend, James T.; Colonius, Hans

    2005-01-01

    The maximum and minimum of a sample from a probability distribution are extremely important random variables in many areas of psychological theory, methodology, and statistics. For instance, the behavior of the mean of the maximum or minimum processing time, as a function of the number of component random processing times ("n"), has been studied…

  15. Heart rate slopes during 6‐min walk test in pulmonary arterial hypertension, other lung diseases, and healthy controls

    Tonelli, Adriano R.; Wang, Xiao‐Feng; Alkukhun, Laith; Zhang, Qi; Dweik, Raed A.; Minai, Omar A.

    2014-01-01

    Abstract Six‐minute walk test (6MWT) continues to be a useful tool to determine the functional capacity in patients with vascular and other lung diseases; nevertheless, it has a limited ability to predict prognosis in this context. We tested whether the heart rate (HR) acceleration and decay slopes during the 6‐m walk test are different in patients with pulmonary arterial hypertension (PAH), other lung diseases, and healthy controls. In addition, we assessed whether the HR slopes are associat...

  16. Targeting Lifestyle Behavior Change in Adults with NAFLD During a 20-min Consultation: Summary of the Dietary and Exercise Literature

    Hallsworth, Kate; Avery, Leah; Trenell, Michael I.

    2016-01-01

    Non-alcoholic fatty liver disease (NAFLD) is largely linked to poor diet, lack of physical activity/exercise, and being overweight. In the absence of approved pharmaceutical agents, lifestyle modification, encompassing dietary change and increased physical activity/exercise to initiate weight loss, is the recommended therapy for NAFLD. Despite this, the use of lifestyle therapy within clinical settings is lacking with limited guidance available about what it should involve, how it should be d...

  17. Energetic particle activity at 5-min and 10-s time resolution in the magnetotail and its relation to auroral activity

    Using data from the JHU/APL experiments on the Imp 7 and 8 spacecraft, we have examined several energetic (E/sub p/ or approx. =0.2 meV) particle bursts associated with substorm events in the magnetotail. During these events the spacecraft were within approx.10 R/sub E/ of the nominal neutral sheet (D/sub S/Mapprox. =0) and within approx.20 R/sub E/ of each other. Individual proton an electron bursts observed by both spacecraft do not always coincide nor does magnetotail activity correlate strongly with auroral activity on time scales less than approx.1 hour. This may be a consequence of the magnetic connection of the spacecraft to the region producing the energetic particles. Strong proton anisotropies are observed during most events. Several of the bursts exhibit rapid onsets and slow, near-exponential decays with repetitive injections. Combining magnetic field and particle measurements on Imp 8, we can determine the pitch angle distributions with a time resolution of approx.10 s. During intense particle bursts the 0.3-MeV protons exhibit unidirection of bidirectional anisotropies along the magnetic field. At othe times, the protons exhibited anisotropies indicating motion from dawn to dusk across field lines. Both types of proton anisotropies persist for minutes, suggesting that the mechanism generating them must be active for at least as long. The energetic electrons tend not to be anisotropic, at least to the same degree as the protons. The data suggest the presence of small localized acceleration regions in the magnetotial which are observable when magnetically connected to the spacecraft. Little convincing evidence is found for a single neutral line extending across the width of the magnetotail

  18. Minäkö kiusaaja? Kiusaamiskysely-Saimaan ammattikorkeakoulun sosiaali-ja terveysalan yksikön opiskelijoille

    Havanka, Mira

    2011-01-01

    Opinnäytetyön tarkoituksena oli selvittää tapahtuuko Saimaan ammattikorkeakoulussa,SOTE:ssa (sosiaali- ja terveysala), kiusaamista ja kokevatko ammattikorkeakoulun opiskelijat puuttumiskeinot riittäviksi. Kiusaamisen on todettu olevan yleistä opiskelu- ja työympäristöissä. Se vaikuttaa koko yhteisön hyvinvointiin,ei vain kiusattuun ja kiusaajaan. Kiusaamisen ennalta ehkäisemisellä on kauaskantoiset vaikutukset, ja sen avulla voidaan ehkäistä vaikeiden ongelmien syntyminen yksilölle ja yhteisö...

  19. "Minäkin tarvitsen ihmisen aikaa." : Asiakaslähtöinen kyselylomake HelsinkiMission puhelinpalveluohjauksen tukena.

    Suomi, Marja; Kajava, Marjo; Loponen, Sirpa

    2012-01-01

    Tämä opinnäytetyö toteutettiin tutkimuksellisena kehittämistyönä, jossa tarkasteltiin viiden helsinkiläisen kotona asuvan ikäihmisen toiminnallisuutta. Kehittämisen kohteena oli sosiaalialan järjestön HelsinkiMission puhelinpalveluohjauksen kyselylomake. Puhelinpalveluohjauksen haasteeksi nousi asiakasnäkökulman esille tuominen ja kuinka saada selville puhelimessa ikäihmisen toimintakyky. Kehittämistyössä tavoitteena oli tuottaa tietoa kotikäyntien avulla. Kehittämistehtävänä oli sel...

  20. Listening Summary Translation Exam (LSTE) in Taiwanese (Also Known As) Minnan, Southern Fukienese, Southern Min, Xiamen, Amoy. Final Project Report.

    Stansfield, Charles W.; Wu, Weiping; Liu, Ching-Ching

    The report details development and validation of a test designed to assess the ability to comprehend and summarize, in English, recorded conversations spoken in Taiwanese. The language and topics of the exam are representative of conversations that federal law enforcement or intelligence agencies may need to monitor in this language. The report is…