WorldWideScience

Sample records for 10-year regional population-based

  1. Natural history of heartburn: A 10-year population-based study

    Linda Bjork Olafsdottir; Hallgrimur Gudjonsson; Heidur Hrund Jonsdottir; Bjarni Thjodleifsson

    2011-01-01

    AIM: To study the natural history and prevalence of heartburn at a 10-year interval, and to study the effect of heartburn on various symptoms and activities.METHODS: A population-based postal study was carried out. Questionnaires were mailed to the same ageand gender-stratified random sample of the Icelandic population (aged 18-75 years) in 1996 and again in 2006. Subjects were classified with heartburn if they reported heartburn in the preceding year and/or week,based on the definition of heartburn.RESULTS: Heartburn in the preceding year was reported in 42.8% (1996) and 44.2% (2006) of subjects, with a strong relationship between those who experienced heartburn in both years. Heartburn in the preceding week was diagnosed in 20.8%. There was a significant relationship between heartburn, dyspepsia and irritable bowel syndrome. Individuals with a body mass index (BMI)below or higher than normal weight were more likely to have heartburn. Heartburn caused by food or beverages was reported very often by 20.0% of subjects.CONCLUSION: Heartburn is a common and chronic condition. Subjects with a BMI below or higher than normal weight are more likely to experience heartburn.Heartburn has a great impact on daily activities, sleep and quality of life.

  2. Health-related Quality of Life in Inflammatory Bowel Disease in a European-wide Population-based Cohort 10 Years After Diagnosis

    Huppertz-Hauss, Gert; Høivik, Marte Lie; Langholz, Ebbe; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2015-01-01

    Background: Chronic inflammatory bowel disease (IBD) negatively affects the patient's health-related quality of life (HRQoL). Only a few population-based studies have compared the HRQoL of patients with the background population. The aim of this study was to evaluate the HRQoL in a European cohort of patients with ulcerative colitis and Crohn's disease 10 years after diagnosis (European Collaborative study group of Inflammatory Bowel Disease) compared with the national background population i...

  3. Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort

    Dankner Rachel

    2012-08-01

    Full Text Available Abstract Background Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incidence; and between the use of specific glucose-lowering medications, as well as no drug exposure, and cancer incidence. Methods/design This is a population based historical cohort study of all individuals aged 21 years or older (about 2,300,000 who were insured by Clalit Health Services, the largest health maintenance organization in Israel during a ten-year study period. Four study groups will be established according to the status of diabetes and cancer at study entry, Jan 1, 2002: cancer free, diabetes free; cancer free, diabetes prevalent; cancer prevalent, diabetes free; and cancer prevalent, diabetes prevalent. Individuals without diabetes at study entry will be followed for diabetes incidence, and all four groups will be followed for specific cancer incidence, including second primary neoplasms. Glucose control will be assessed by HbA1c and by fasting plasma glucose levels. Time dependent regression models for cancer incidence will account for glucose-lowering medications as they are added and changed over the follow-up period. A large number of demographic and clinical variables will be considered, including: age, gender, BMI, smoking status, concomitant medications, glucose control (assessed by HbA1c and by fasting plasma glucose and cancer screening tests. Discussion Strengths of this study include the large population; high quality comprehensive data; comparison to individuals without diabetes, and to those with diabetes but not treated with glucose-lowering medications; and the extensive range of variables available for analysis. The great increases in diabetes prevalence and in treatment options render this

  4. Health-related quality of life in inflammatory bowel disease in a European-wide population-based cohort 10 years after diagnosis

    Huppertz-Hauss, Gert; Høivik, Marte Lie; Langholz, Ebbe;

    2015-01-01

    Cohen's effect size index. RESULTS: Seven hundred sixty-nine patients were eligible for the study. We registered statistically significant and clinically relevant decreases in the short form health survey-36 dimensional scores in patients with symptoms at the time of follow-up and for patients reporting......BACKGROUND: Chronic inflammatory bowel disease (IBD) negatively affects the patient's health-related quality of life (HRQoL). Only a few population-based studies have compared the HRQoL of patients with the background population. The aim of this study was to evaluate the HRQoL in a European cohort...... of patients with ulcerative colitis and Crohn's disease 10 years after diagnosis (European Collaborative study group of Inflammatory Bowel Disease) compared with the national background population in each country and to assess possible country-specific differences. METHODS: Patients with IBD from 7...

  5. Recurrent bacteraemia: A 10-year regional population-based study of clinical and microbiological risk factors

    Jensen, U.S.; Knudsen, J.D.; Andersen, Christian Østergaard;

    2010-01-01

    pathogen identity, site of infection and time frame, and not restricted to homologous pathogens. Results: We identified 8672 patients with first-time bacteraemia, of whom 1003 (12%) had a recurrence within 1 year. The proportion of mono-microbial bacteraemia was similar for first (86%) and recurrent...... episodes (84%). An unknown focus was common in both episodes (22.7 and 29.1%, respectively). Independent predictors of a recurrence (incidence rate ratio, 95% confidence interval) included health care-associated (2.4; 1.9-3.0) and nosocomial bacteraemia (2.1; 1.8-2.6), poly-microbial Gram.......4-2.8), endocarditis ( 2.7; 1.6-4.3), and an unknown focus (1.9; 1.5-2.3). Conclusions: This study showed recurrent bacteraemia to be common and the following risk factors were identified: a health care-associated or nosocomial origin, poly-microbial or fungal aetiology, a focus within the abdomen, endocardium, iv...

  6. Raw and processed fruit and vegetable consumption and 10-year coronary heart disease incidence in a population-based cohort study in the Netherlands.

    Linda M Oude Griep

    Full Text Available BACKGROUND: Prospective cohort studies have shown that high fruit and vegetable consumption is inversely associated with coronary heart disease (CHD. Whether food processing affects this association is unknown. Therefore, we quantified the association of fruit and vegetable consumption with 10-year CHD incidence in a population-based study in the Netherlands and the effect of processing on these associations. METHODS: Prospective population-based cohort study, including 20,069 men and women aged 20 to 65 years, enrolled between 1993 and 1997 and free of cardiovascular disease at baseline. Diet was assessed using a validated 178-item food frequency questionnaire. Hazard ratios (HR were calculated for CHD incidence using multivariable Cox proportional hazards models. RESULTS: During a mean follow-up time of 10.5y, 245 incident cases of CHD were documented, which comprised 211 non-fatal acute myocardial infarctions and 34 fatal CHD events. The risk of CHD incidence was 34% lower for participants with a high intake of total fruit and vegetables (>475 g/d; HR: 0.66; 95% CI: 0.45-0.99 compared to participants with a low total fruit and vegetable consumption (≤241 g/d. Intake of raw fruit and vegetables (>262 g/d vs ≤92 g/d; HR: 0.70; 95% CI: 0.47-1.04 as well as processed fruit and vegetables (>234 g/d vs ≤113 g/d; HR: 0.79; 95% CI: 0.54-1.16 were inversely related with CHD incidence. CONCLUSION: Higher consumption of fruit and vegetables, whether consumed raw or processed, may protect against CHD incidence.

  7. Subclinical hypothyroidism is associated with increased risk for cancer mortality in adult Taiwanese-a 10 years population-based cohort.

    Fen-Yu Tseng

    Full Text Available The association between subclinical hypothyroidism (SCH and cancer mortality is seldom discussed.A total of 115,746 participants without thyroid disease history, aged 20 and above, were recruited from four nationwide health screening centers in Taiwan from 1998 to 1999. SCH was defined as a serum thyroid-stimulating hormone (TSH level of 5.0-19.96 mIU/L with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47-4.9 mIU/L. Cox proportional hazards regression analyses were used to estimate the relative risks (RRs of death from cancer for adults with SCH during a 10-year follow-up period.Among 115,746 adults, 1,841 had SCH (1.6% and 113,905 (98.4% had euthyroidism. There were 1,532 cancer deaths during the 1,034,082 person-years follow-up period. Adjusted for age, gender, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol drinking, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval of cancer deaths among subjects with SCH versus euthyroid subjects were 1.51 (1.06 to 2.15. Cancer site analysis revealed a significant increased risk of bone, skin and breast cancer among SCH subjects (RR 2.79, (1.01, 7.70. The risks of total cancer deaths were more prominent in the aged (RR 1.71, (1.02 to 2.87, in females (RR 1.69 (1.08 to 2.65, and in heavy smokers (RR 2.24, (1.19 to 4.21.Subjects with SCH had a significantly increased risk for cancer mortality among adult Taiwanese. This is the first report to demonstrate the association between SCH and cancer mortality.

  8. Quantifying 10 years of Improvements in Earthquake and Tsunami Monitoring in the Caribbean and Adjacent Regions

    von Hillebrandt-Andrade, C.; Huerfano Moreno, V. A.; McNamara, D. E.; Saurel, J. M.

    2014-12-01

    The magnitude-9.3 Sumatra-Andaman Islands earthquake of December 26, 2004, increased global awareness to the destructive hazard of earthquakes and tsunamis. Post event assessments of global coastline vulnerability highlighted the Caribbean as a region of high hazard and risk and that it was poorly monitored. Nearly 100 tsunamis have been reported for the Caribbean region and Adjacent Regions in the past 500 years and continue to pose a threat for its nations, coastal areas along the Gulf of Mexico, and the Atlantic seaboard of North and South America. Significant efforts to improve monitoring capabilities have been undertaken since this time including an expansion of the United States Geological Survey (USGS) Global Seismographic Network (GSN) (McNamara et al., 2006) and establishment of the United Nations Educational, Scientific and Cultural Organization (UNESCO) Intergovernmental Coordination Group (ICG) for the Tsunami and other Coastal Hazards Warning System for the Caribbean and Adjacent Regions (CARIBE EWS). The minimum performance standards it recommended for initial earthquake locations include: 1) Earthquake detection within 1 minute, 2) Minimum magnitude threshold = M4.5, and 3) Initial hypocenter error of seismic network capability, we can optimize the distribution of ICG-Caribe EWS seismic stations and select an international network that will be contributed from existing real-time broadband national networks in the region. Sea level monitoring improvements both offshore and along the coast will also be addressed. With the support of Member States and other countries and organizations it has been possible to significantly expand the sea level network thus reducing the amount of time it now takes to verify tsunamis.

  9. Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: Environmental Determinants in Young people

    Panter Jenna

    2008-11-01

    Full Text Available Abstract Background The SPEEDY study was set up to quantify levels of physical activity (PA and dietary habits and the association with potential correlates in 9–10 year old British school children. We present here the analyses of the PA, dietary and anthropometry data. Methods In a cross-sectional study of 2064 children (926 boys, 1138 girls in Norfolk, England, we collected anthropometry data at school using standardised procedures. Body mass index (BMI was used to define obesity status. PA was assessed with the Actigraph accelerometer over 7 days. A cut-off of ≥ 2000 activity counts was used to define minutes of moderate-to-vigorous PA (MVPA. Dietary habits were assessed using the Health Behaviour in School Children food questionnaire. Weight status was defined using published international cut-offs (Cole, 2000. Differences between groups were assessed using independent t-tests for continuous data and chi-squared tests for categorical data. Results Valid PA data (>500 minutes per day on ≥ 3 days was available for 1888 children. Mean (± SD activity counts per minute among boys and girls were 716.5 ± 220.2 and 635.6 ± 210.6, respectively (p Conclusion Results indicate that almost 70% of children meet national PA guidelines, indicating that a prevention of decline, rather than increasing physical activity levels, might be an appropriate intervention target. Promotion of daily fruit and vegetable intake in this age group is also warranted, possibly focussing on children from lower socioeconomic backgrounds.

  10. 10 years Rossendorf Tandem

    10 years successful operation of the Rossendorf Tandem is an occasion to give an account about the most important developments and results in the fields of accelerator technology and utilization of this machine. The selected and sum up contributions reflect the systematic orientation on increasing the availability of the accelerator as well as its improvement to an effective heavy ion accelerator to extend the quantitative and qualitative possibilities of application in nuclear physical experiments. (author)

  11. Benzo[a]pyrene contamination in Rostov Region of Russian Federation: A 10-year retrospective of soil monitoring under the effect of long-term technogenic pollution

    Svetlana Sushkova

    2016-04-01

    Full Text Available The aim of the current work was to study the main tendencies in the accumulation and distribution of benzo[a]pyrene in soils of the affected zone of the Novocherkassk regional power plant. Studies were conducted on the soils of monitoring plots subjected to Novocherkassk regional power plant emissions. Monitoring plots were established at different distances from the Novocherkassk regional power plant (1.0–20.0 km. Regularities in the accumulation and distribution of benzo[a]pyrene in chernozemic, meadow-chernozemic, and alluvial soils under the effect of aerotechnogenic emissions from the Novocherkassk regional power plant have been revealed on the basis of long-term monitoring studies (from 2002 to 2011. The tendencies in the distribution and accumulation of BaP in the studied soils coincided during the 10 years of monitoring studies. It has been found the 5-km zone to the northwest from the power station, which coincides with the predominant wind direction, is most subjected to contamination by benzo[a]pyrene, with the maximum accumulation at a distance of about 1.6 km from the source. Dynamics of pollutant accumulation in soils depends on number of Novocherkassk regional power plant emissions. The content of benzo[a]pyrene in the soil is an indicator of the technogenic load impact on the areas, for which the combustion products of hydrocarbon fuel are the major pollutants. A gradual decrease of the pollutant content in the soils was revealed during the period from 2002 to 2011. It explained by the significant decrease in the volume of pollutant emissions from the plant and the self-purification capacity of soils and mechanisms of benzo[a]pyrene degradation.

  12. Antipsychotic polypharmacy in a regional health service: a population-based study

    Bernardo Miguel

    2012-05-01

    Full Text Available Abstract Background To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain, focusing on the use of clozapine and long-acting injections (LAI. Methods Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA from the Anatomical Therapeutic Chemical classification (ATC code N05A (except lithium were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. Results A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9% corresponded to an antipsychotic combination, 47,386 (66.7% to monotherapy and 13,763 (19.4% to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1% and oral risperidone (36.4% were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8% revealed 198 different combinations, the most frequent being the association of FGA and SGA (62.0%. Clozapine was dispensed to 2.3% of patients. Of those who were receiving antipsychotics in combination, 6.6% were given clozapine, being clozapine plus amisulpride the most frequent association (22.8%. A total of 3.800 patients (5.4% were given LAI antipsychotics, and 2.662 of these (70.1% were in combination. Risperidone was the most widely used LAI. Conclusions The scant evidence available regarding the efficacy of combining different antipsychotics contrasts with the high number and variety of combinations prescribed to outpatients, as well as with the limited use of clozapine.

  13. Population-based laboratory surveillance for Giardia sp. and Cryptosporidium sp. infections in a large Canadian health region

    Laupland Kevin B

    2005-09-01

    Full Text Available Abstract Background Giardia lamblia (intestinalis and Cryptosporidium parvum are the two most important intestinal parasites infecting North Americans but there is a paucity of active population-based surveillance data from Canada. This study determined the incidence of and demographic risk factors for developing Giardia sp. and Cryptosporidium sp. infections in a general Canadian population. Methods Population-based laboratory surveillance was conducted among all residents of the Calgary Health Region (CHR; population ≅ 1 million during May 1, 1999 and April 30, 2002. Results Giardia sp. infection occurred at a rate of 19.6 per 100,000 populations per year. Although the yearly incidence was stable, a significant seasonal variation was observed with a peak in late summer to early fall. Males were at higher risk for development of this infection as compared to females (21.2 vs. 17.9 per 100,000/yr; relative risk (RR 1.19; 95% confidence interval (CI, 1.00–1.40, p = 0.047, and there was a significant decrease in risk associated with an increasing age. Cryptosporidium sp. infection occurred at an overall rate of 6.0 per 100,000 populations per year although a large outbreak of Cryptosporidium sp. infections occurred in the second half of the summer of 2001. During August and September of 2001, the incidence of cryptosporidiosis was 55.1 per 100,000 per year as compared to 3.1 per 100,000 per year for the remainder of the surveillance period (p Conclusion This study provides important information on the occurrence and demographic risk groups for acquisition of giardiasis and cryptosporidiosis in a non-selected Canadian population.

  14. ESA-MERIS 10-Year Mission Reveals Contrasting Phytoplankton Bloom Dynamics in Two Tropical Regions of Northern Australia

    David Blondeau-Patissier

    2014-04-01

    Full Text Available The spatial and temporal variability of phytoplankton blooms was investigated in two tropical coastal regions of northern Australia using the MEdium Resolution Imaging Spectrometer (MERIS full mission (2002–2012 reduced resolution dataset. Satellite-derived proxies for phytoplankton (Chlorophyll-a (Chl, Fluorescence Line Height (FLH, Maximum Chlorophyll Index (MCI and suspended sediment (Total Suspended Matter (TSM were jointly analyzed for two clusters of the Great Barrier Reef Wet tropics (GBRW; 15°–19.5°S; Queensland and the Van Diemen Gulf (VDG; 9°–13°S; Northern Territory. The analysis of time-series and Hovmöller diagrams of the four MERIS products provided a unique perspective on the processes linking phytoplankton blooms and river runoff, or resuspension, across spatio-temporal scales. Both regions are characterized by a complex oceanography and seasonal inflows of sediment, freshwater and nutrients during the tropical wet season months (November to April. The GBRW is characterized by a great variability in water clarity (Secchi depth 0–25 m. A long history of agricultural land use has led to a large increase in the seasonal discharge of sediments and nutrients, triggering seasonal phytoplankton blooms (>0.4 mg∙m−3 between January and April. In contrast, the VDG is a poorly flushed, turbid (Secchi depth <5 m environment with strong tidal-energy (4–8 m and very limited land use. Phytoplankton blooms here were found to have higher Chl concentrations (>1.0 mg∙m−3 than in the GBRW, occurring up to twice a year between January and April. Over the 10-year MERIS mission, a weak decline in Chl and TSM was observed for the VDG (Sen slope: −2.85%/decade, τ = −0.32 and −3.57%/decade, τ = −0.24; p 0.05, while no significant trend in those two satellite products was observed in the GBRW. Cyanobacteria surface algal blooms occur in both regions between August and October. The MCI and FLH products were found to

  15. Population-based estimates of the occurrence of multiple vs first primary basal cell carcinomas in 4 European regions

    E. de Vries (Esther); R. Micallef (R.); D.H. Brewster; J.H. Gibbs (James); S.C. Flohil (Sophie); O. Saksela (O.); R. Sankila (R.); A.D. Forrest (A.); M. Trakatelli (Myrto); J.W.W. Coebergh (Jan Willem); C.M. Proby (C.)

    2012-01-01

    textabstractObjective: To estimate the population-based incidence of first and multiple basal cell carcinomas (BCCs) throughout Europe. Design: The registry practices of 4 population-based cancer registries that routinely register BCC incidence were evaluated for inclusion of first and subsequent hi

  16. 10 YEARS AFTER NATO MEMBERSHIP

    10 years after NATO Membership. An Anniversary in the Shadow of a Crisis”, indeholder artikler fra politiske aktører, diplomater og forskere, der alle bidrog til til konferencen af samme navn, hvor den 10-året for baltisk medlemskab af NATO var omdrejningspunktet. Udover den danske forsvarsminis...... for Estland, Letland og Litauen i Danmark....

  17. A 10-Year Assessment of Hemlock Decline in the Catskill Mountain Region of New York State Using Hyperspectral Remote Sensing Techniques.

    Hanavan, Ryan P; Pontius, Jennifer; Hallett, Richard

    2015-02-01

    The hemlock woolly adelgid is a serious pest of Eastern and Carolina hemlock in the eastern United States. Successfully managing the hemlock resource in the region depends on careful monitoring of the spread of this invasive pest and the targeted application of management options such as biological control, chemical, or silvicultural treatments. To inform these management activities and test the applicability of a landscape-scale remote sensing effort to monitor hemlock condition, hyperspectral collections, and concurrent ground-truthing in 2001 and 2012 of hemlock condition were compared with field metrics spanning a 10-yr survey in the Catskills region of New York. Fine twig dieback significantly increased from 9 to 15% and live crown ratio significantly decreased from 67 to 56% in 2001 and 2012, respectively. We found a significant shift from 59% "healthy" hemlock in 2001 to only 16% in 2012. However, this shift from healthy to declining classifications was mostly a shift to decline class 2 "early decline". These results indicate that while there has been significant increase in decline symptoms as measured in both field and remote sensing assessments, a majority of the declining areas identified in the resulting spatial coverages remain in the "early decline" category and widespread mortality has not yet occurred. While this slow decline across the region stands in contrast to many reports of mortality within 10 yr, the results from this work are in line with other long-term monitoring studies and indicate that armed with the spatial information provided here, continued management strategies can be focused on particular areas to help control the further decline of hemlock in the region. PMID:26470138

  18. Current Land Subsidence and Sea Level Rise along the North American Coastal Region: Observations from 10-Year (2005-2014) Closely-Spaced GPS and Tide Gauge Stations

    Yang, L.; Yu, J.; Kearns, T.; Wang, G.

    2014-12-01

    Strong evidence has proved that the global sea-level is now rising at an increased rate and it is projected to continue to rise. However the rise of the sea-level is not uniform around the world. The local or relative sea-level rise will be of great concern to the coastal regions. The combination of the land subsidence and global sea-level rise causes the relative sea-level to rise. Relative sea-level rise increases the risk of flooding and wetland loss problems in near coastal areas, which in turn have important economic, environmental, and human health consequences for the heavily populated and ecologically important coastal region. However the role played by the coastal land subsidence is commonly absent during the discussion of sea-level rise problems. The sea-level can be measured in two ways: satellite altimetry and tide gauges. The sea-level measured by satellite is called the geocentric sea-level that is relative to earth center and the one measured by tide gauges is called local sea-level that is relative to the land. The tide gauge measurements of the local sea-level do not distinguish between whether the water is rising or the land is subsiding. In some coastal areas, land subsidence is occurring at a higher rate than the geocentric sea-level is rising. This can have a great local effect. GPS technology has proven to be efficient and accurate for measuring and tracking absolute land elevation change. There are about 300 publically available Continuously Operating Reference GPS Stations (CORS) within 15 km from the coastal line along North America. In this study, we use publicly available long-history (> 5 years) CORS data to derive current (2005-2014) coastal subsidence in North America. Absolute coastal sea-level rise will be determined by combing the land subsidence and relative sea-level measurements. This study shows that the relative sea-level of the Alaska area appears to be falling because the land is uplifting; this study also shows that the

  19. The Association between Regional Environmental Factors and Road Trauma Rates: A Geospatial Analysis of 10 Years of Road Traffic Crashes in British Columbia, Canada

    Brubacher, Jeffrey R.; Chan, Herbert; Erdelyi, Shannon; Schuurman, Nadine; Amram, Ofer

    2016-01-01

    collisions. Regions with dedicated traffic officers had fewer fatal crashes and fewer fatal speed related crashes but more rear end crashes and more crashes involving cyclists or pedestrians. The number of traffic citations per 1000 drivers was positively associated with total crashes, fatal crashes, total fatalities, fatal speeding crashes, injury crashes, single vehicle night-time crashes, and heavy vehicle crashes. Possible explanations for these associations are discussed. Conclusions There is wide variation in per capita rates of motor vehicle crashes across BC police patrols. Some variation is explained by factors such as climate, road type, remoteness, socioeconomic variables, and enforcement intensity. The ability of explanatory factors to predict crash rates would be improved if considered with local traffic volume by all travel modes. PMID:27099930

  20. Regional inequalities in under-5 mortality in Nigeria: a population-based analysis of individual- and community-level determinants

    Antai Diddy

    2011-01-01

    Abstract Background Regions with geographically diverse ecology and socioeconomic circumstances may have different disease exposures and child health outcomes. This study assessed variations in the risks of death in children under age 5 across regions of Nigeria and determined characteristics at the individual and community levels that explain possible variations among regions. Methods Multilevel Cox proportional hazards analysis was performed using a nationally representative sample of 6,029...

  1. Genetic structure of five Huanghe schizothoracin Schizopygopsis pylzovi populations based on mtDNA control region sequences

    QI De-Lin; Chao, Yan; Guo, Song-Chang; ZHAO Xin-Quan

    2008-01-01

    Huanghe schizothoracin Schizopygopsis pylzovi is a freshwater fish endemic to Qinghai-Tibetan Plateau, which distributes mainly in the Qiadam drainage and the upper reaches of Yellow River in the northern and northeastern Qinghai-Tibetan Plateau. So far little is known about the genetic diversity, radiation and population structure. In the present study, the sequence of mitochondrial control region (821bp) of 99 individuals representing five populations in the distribution regions were sequen...

  2. Breast cancer screening disparities among immigrant women by world region of origin: a population-based study in Ontario, Canada.

    Vahabi, Mandana; Lofters, Aisha; Kumar, Matthew; Glazier, Richard H

    2016-07-01

    Rates of mammography screening for breast cancer are disproportionately low in certain subgroups including low-income and immigrant women. The purpose of the study was to examine differences in rates of appropriate breast cancer screening (i.e., screening mammography every 2 years) among Ontario immigrant women by world region of origin and explore the association between appropriate breast cancer screening among these women groups and individual and structural factors. A cohort of 183,332 screening-eligible immigrant women living in Ontario between 2010 and 2012 was created from linked databases and classified into eight world regions of origin. Appropriate screening rates were calculated for each region by age group and selected sociodemographic, immigration, and healthcare-related characteristics. The association between appropriate screening across the eight regions of origin and selected sociodemographic, immigration, and health-related characteristics was explored using multivariate Poisson regression. Screening varied by region of origin, with South Asian women (48.5%) having the lowest and Caribbean and Latin American women (63.7%) the highest cancer screening rates. Factors significantly associated with lower screening across the world regions of origin included living in the lowest income neighborhoods, having a refugee status, being a new immigrant, not having a regular physical examination, not being enrolled in a primary care patient enrollment model, having a male physician, and having an internationally trained physician. Multiple interventions entailing cross-sector collaboration, promotion of patient enrollment models, community engagement, comprehensive and intensive outreach to women, and knowledge translation and transfer to physicians should be considered to address screening disparities among immigrant population. Consideration should be given to design and delivery of culturally appropriate and easily accessible cancer screening programs

  3. Regional inequalities in under-5 mortality in Nigeria: a population-based analysis of individual- and community-level determinants

    Antai Diddy

    2011-03-01

    Full Text Available Abstract Background Regions with geographically diverse ecology and socioeconomic circumstances may have different disease exposures and child health outcomes. This study assessed variations in the risks of death in children under age 5 across regions of Nigeria and determined characteristics at the individual and community levels that explain possible variations among regions. Methods Multilevel Cox proportional hazards analysis was performed using a nationally representative sample of 6,029 children from 2,735 mothers aged 15-49 years and nested within 365 communities from the 2003 Nigeria Demographic and Health Survey. Hazard ratios (HR with 95% confidence intervals (CI were used to express measures of association among the characteristics. Variance partition coefficients and Wald statistic were used to express measures of variation. Results Patterns of under-5 mortality cluster within families and communities. The risks of under-5 deaths were significantly higher for children of mothers residing in the South South (Niger Delta region (HR: 1.30; 95% CI: 1.76-2.20 and children of mothers residing in communities with a low proportion of mothers attending prenatal care by a doctor (HR: 1.36; 95% CI: 1.15-1.86. In addition, the cross-level interaction between mothers' education and community prenatal care by a doctor was associated with a more than 40% higher risk of dying (HR: 1.41; 95% CI: 1.21-1.78. Conclusion The findings suggest the need to differentially focus on community-level interventions aimed at increasing maternal and child health care utilization and improving the socioeconomic position of mothers, especially in disadvantaged regions such as the South South (Niger Delta region. Further studies on community-levels determinants of under-5 mortality are needed.

  4. Swift: 10 Years of Discovery

    The conference Swift: 10 years of discovery was held in Roma at La Sapienza University on Dec. 2-5 2014 to celebrate 10 years of Swift successes. Thanks to a large attendance and a lively program, it provided the opportunity to review recent advances of our knowledge of the high-energy transient Universe both from the observational and theoretical sides. When Swift was launched on November 20, 2004, its prime objective was to chase Gamma-Ray Bursts and deepen our knowledge of these cosmic explosions. And so it did, unveiling the secrets of long and short GRBs. However, its multi-wavelength instrumentation and fast scheduling capabilities made it the most versatile mission ever flown. Besides GRBs, Swift has observed, and contributed to our understanding of, an impressive variety of targets including AGNs, supernovae, pulsars, microquasars, novae, variable stars, comets, and much more. Swift is continuously discovering rare and surprising events distributed over a wide range of redshifts, out to the most distant transient objects in the Universe. Such a trove of discoveries has been addressed during the conference with sessions dedicated to each class of events. Indeed, the conference in Rome was a spectacular celebration of the Swift 10th anniversary. It included sessions on all types of transient and steady sources. Top scientists from around the world gave invited and contributed talks. There was a large poster session, sumptuous lunches, news interviews and a glorious banquet with officials attending from INAF and ASI. All the presentations, as well as several conference pictures, can be found in the conference website (http://www.brera.inaf.it/Swift10/Welcome.html). These proceedings have been collected owing to the efforts of Paolo D’Avanzo who has followed each paper from submission to final acceptance. Our warmest thanks to Paolo for all his work. The Conference has been made possible by the support from La Sapienza University as well as from the ARAP

  5. Prevalence of risk factors for fractures and use of DXA scanning in Danish women. A regional population-based study

    Rubin, Kathrine Hass; Abrahamsen, B; Hermann, A P;

    2011-01-01

    To determine the relationship between risk factors and use of DXA scans. Our study showed a relatively high use of DXA in low-risk women and the relatively low coverage in women with multiple risk factors. Moreover, distance to DXA clinics, age, and socio-economic factors are associated with the...... use of DXA. INTRODUCTION: To determine the relationship between risk factors for fracture and use of DXA scans in Danish women in relation to distance to DXA clinics and socio-economic factors. METHODS: From the Danish National Civil Register we randomly selected 5,000 women aged 40-90 years living in...... the region of Southern Denmark to receive a mailed questionnaire concerning risk factors for fractures. RESULTS: The respondents rate was 84% and 77% of the invited population were available for analysis. A total of 10.3% of the women without risk factors and only 36% of the women with three or more...

  6. [Analysis of genetic diversity of Russian regional populations based on common STR markers used in DNA identification].

    Pesik, V Yu; Fedunin, A A; Agdzhoyan, A T; Utevska, O M; Chukhraeva, M I; Evseeva, I V; Churnosov, M I; Lependina, I N; Bogunov, Yu V; Bogunova, A A; Ignashkin, M A; Yankovsky, N K; Balanovska, E V; Orekhov, V A; Balanovsky, O P

    2014-06-01

    We conducted the first genetic analysis of a wide a range of rural Russian populations in European Russia with a panel of common DNA markers commonly used in criminalistics genetic identification. We examined a total of 647 samples from indigenous ethnic Russian populations in Arkhangelsk, Belgorod, Voronezh, Kursk, Rostov, Ryazan, and Orel regions. We employed a multiplex genotyping kit, COrDIS Plus, to genotype Short Tandem Repeat (STR) loci, which included the genetic marker panel officially recommended for DNA identification in the Russian Federation, the United States, and the European Union. In the course of our study, we created a database of allelic frequencies, examined the distribution of alleles and genotypes in seven rural Russian populations, and defined the genetic relationships between these populations. We found that, although multidimensional analysis indicated a difference between the Northern gene pool and the rest of the Russian European populations, a pairwise comparison using 19 STR markers among all populations did not reveal significant differences. This is in concordance with previous studies, which examined up to 12 STR markers of urban Russian populations. Therefore, the database of allelic frequencies created in this study can be applied for forensic examinations and DNA identification among the ethnic Russian population over European Russia. We also noted a decrease in the levels of heterozygosity in the northern Russian population compared to ethnic populations in southern and central Russia, which is consistent with trends identified previously using classical gene markers and analysis of mitochondrial DNA. PMID:25715463

  7. [Overweight among young people in a city in the Brazilian semiarid region: a population-based study].

    Monteiro, Aline Rodrigues; Dumith, Samuel Carvalho; Gonçalves, Tatiane Santos; Cesar, Juraci Almeida

    2016-04-01

    The scope of this article is to measure the prevalence and identify factors associated with excess weight among young people living in the city of Caracol, Piaui, Brazil. Qualified interviewers applied a standardized questionnaire and assessed the anthropometric measurements of all young people (13 to 19 years of age) in their households. The questionnaires sought information on demographic, socioeconomic and behavioral characteristics. The outcome was overweight in young people (BMI > 1 z score) calculated on the basis of body mass index (BMI) and classified in accordance with the new parameters of the World Health Organization. Poisson regression with robust adjustment of variance was used for the statistical analysis. Of the 1,088 young people studied, 10.5% were overweight. The occurrence of the outcome varied from 6% for young people belonging to the second income quartile to 19% for adolescents with a height deficit for their age. Even with the prevalence of overweight being below the national average in the semiarid region, the factors associated with their occurrence are already equal to the other areas of Brazil and there is a pressing need for early intervention aimed at preventing and reducing the current overweight levels. PMID:27076014

  8. Infection risk factors associated with seropositivity for Toxoplasma gondii in a population-based study in the Central Region, Ghana.

    Abu, E K; Boampong, J N; Ayi, I; Ghartey-Kwansah, G; Afoakwah, R; Nsiah, P; Blay, E

    2015-07-01

    About 20-90% of the world's population has had contact with Toxoplasma gondii parasites. The aim of this study was to determine the seroprevalence and risk factors associated with T. gondii infection in the Central Region, Ghana. A community-based cross-sectional study was conducted in three selected communities. Serum samples were tested for the presence of anti-T. gondii IgG and IgM antibodies by ELISA. A serological criterion for seropositivity was a positive test result for any of the two anti-Toxoplasma IgG or IgM antibodies or a combination of both. In all, 390 participants of mean age 47.0 years consisting of 118 (30.%) males and 272 (69.7%) females were tested. The overall seroprevalence of T. gondii was 85% (333/390) where fishermen, farmers and fishmongers, respectively, had the highest seropositivity. IgG and IgM antibodies were detected in 329 (84%) and 25 (6%), respectively, while both IgG and IgM antibodies were detected in 21 (5%) of the participants. Respectively, 1% (4/390) and 79% (308/390) of participants tested positive for IgM-only and IgG-only antibodies. There was a significant relationship between Toxoplasma seropositivity and contact with soil, presence of a cat in the surrounding area, age, sources of drinking water, level of formal education, and socioeconomic status. The results suggest that the seashore may serve as a good ground for sporulation and survival of Toxoplasma oocysts. PMID:25373611

  9. Hookworm infection and environmental factors in mbeya region, Tanzania: a cross-sectional, population-based study.

    Helene Riess

    Full Text Available BACKGROUND: Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY: Cross-sectional interview data and stool samples from 6,375 participants from nine different sites in Mbeya region, south-western Tanzania, were collected as part of a cohort study. Hookworm infection was assessed by microscopy of duplicate Kato-Katz thick smears from one stool sample from each participant. A geographic information system was used to obtain remotely sensed environmental data such as land surface temperature (LST, vegetation cover, rainfall, and elevation, and combine them with hookworm infection data and with socio-demographic and behavioral data. Uni- and multivariable logistic regression was performed on sites separately and on the pooled dataset. PRINCIPAL FINDINGS: Univariable analyses yielded significant associations for all ecological variables. Five ecological variables stayed significant in the final multivariable model: population density (odds ratio (OR = 0.68; 95% confidence interval (CI = 0.63-0.73, mean annual vegetation density (OR = 0.11; 95% CI = 0.06-0.18, mean annual LST during the day (OR = 0.81; 95% CI = 0.75-0.88, mean annual LST during the night (OR = 1.54; 95% CI = 1.44-1.64, and latrine coverage in household surroundings (OR = 1.02; 95% CI = 1.01-1.04. Interaction terms revealed substantial differences in associations of hookworm infection with population density, mean annual enhanced vegetation index, and latrine coverage between the two sites with the highest prevalence of infection. CONCLUSION/SIGNIFICANCE: This study supports previous findings that remotely sensed data such as vegetation indices, LST, and elevation are strongly associated with hookworm prevalence. However, the results

  10. Regional and neighborhood disparities in the odds of type 2 diabetes: results from 5 population-based studies in Germany (DIAB-CORE consortium).

    Müller, Grit; Kluttig, Alexander; Greiser, Karin Halina; Moebus, Susanne; Slomiany, Uta; Schipf, Sabine; Völzke, Henry; Maier, Werner; Meisinger, Christa; Tamayo, Teresa; Rathmann, Wolfgang; Berger, Klaus

    2013-07-15

    The objective of this study was to investigate the association between residential environment and type 2 diabetes. We pooled cross-sectional data from 5 population-based German studies (1997-2006): the Cardiovascular Disease, Living and Ageing in Halle Study, the Dortmund Health Study, the Heinz Nixdorf Recall Study, the Cooperative Health Research in the Region of Augsburg Study, and the Study of Health in Pomerania. The outcome of interest was the presence of self-reported type 2 diabetes. We conducted mixed logistic regression models in a hierarchical data set with 8,879 individuals aged 45-74 years on level 1; 226 neighborhoods on level 2; and 5 study regions on level 3. The analyses were adjusted for age, sex, social class, and employment status. The odds ratio for type 2 diabetes was highest in eastern Germany (odds ratio = 1.98, 95% confidence interval: 1.81, 2.14) and northeastern Germany (odds ratio = 1.58, 95% confidence interval: 1.40, 1.77) and lowest in southern Germany (reference) after adjustment for individual variables. Neighborhood unemployment rates explained a large proportion of regional differences. Individuals residing in neighborhoods with high unemployment rates had elevated odds of type 2 diabetes (odds ratio = 1.62, 95% confidence interval: 1.25, 2.09). The diverging levels of unemployment in neighborhoods and regions are an independent source of disparities in type 2 diabetes. PMID:23648804

  11. Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

    Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is one of the endemic regions of ESCC, but fewer studies have been done in characterizing the risk factors of ESCC in this area. The aims of this study is to evaluate the etiological roles of demographic parameters, environmental and food-borne carcinogens exposure, and XME polymorphisms in formation of ESCC, and to investigate possible gene-gene and gene-environment interactions associated with ESCC in Huaian, China. A population based case-control study was conducted in 107 ESCC newly diagnosed cases and 107 residency- age-, and sex-matched controls in 5 townships of Huaian. In addition to regular epidemiological and food frequency questionnaire analyses, genetic polymorphisms of phase I enzymes CYP1A1, CYP1B1, CYP2A6, and CYP2E1, and phase II enzymes GSTM1, GSTT1, GSTP1, and microsomal epoxide hydrolase (EPHX) were assessed from genomic DNA using PCR based techniques. Consuming acrid food, fatty meat, moldy food, salted and pickled vegetables, eating fast, introverted personality, passive smoking, a family history of cancer, esophageal lesion, and infection with Helicobacter pylori were significant risk factors for ESCC (P < 0.05). Regular clean up of food storage utensils, green tea consumption, and alcohol abstinence were protective factors for ESCC (P < 0.01). The frequency of the GSTT1 null genotype was higher in cases (59.4%) compared to controls (47.2%) with an odds ratio (OR) of 1.68 and 95% confidence interval (CI) from 0.96 to 2.97 (P = 0.07), especially in males (OR = 2.78; 95% CI = 1.22–6.25; P = 0.01). No associations were found between polymorphisms of CYP1A1, CYP1B1, CYP2A6, CYP2E1, GSTM1, GSTP1, and EPHX and ESCC (P > 0.05). Our results demonstrated that dietary and environmental exposures, some demographic

  12. Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

    Gao Weimin

    2006-12-01

    Full Text Available Abstract Background Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC. Huaian, China, is one of the endemic regions of ESCC, but fewer studies have been done in characterizing the risk factors of ESCC in this area. The aims of this study is to evaluate the etiological roles of demographic parameters, environmental and food-borne carcinogens exposure, and XME polymorphisms in formation of ESCC, and to investigate possible gene-gene and gene-environment interactions associated with ESCC in Huaian, China. Methods A population based case-control study was conducted in 107 ESCC newly diagnosed cases and 107 residency- age-, and sex-matched controls in 5 townships of Huaian. In addition to regular epidemiological and food frequency questionnaire analyses, genetic polymorphisms of phase I enzymes CYP1A1, CYP1B1, CYP2A6, and CYP2E1, and phase II enzymes GSTM1, GSTT1, GSTP1, and microsomal epoxide hydrolase (EPHX were assessed from genomic DNA using PCR based techniques. Results Consuming acrid food, fatty meat, moldy food, salted and pickled vegetables, eating fast, introverted personality, passive smoking, a family history of cancer, esophageal lesion, and infection with Helicobacter pylori were significant risk factors for ESCC (P GSTT1 null genotype was higher in cases (59.4% compared to controls (47.2% with an odds ratio (OR of 1.68 and 95% confidence interval (CI from 0.96 to 2.97 (P = 0.07, especially in males (OR = 2.78; 95% CI = 1.22–6.25; P = 0.01. No associations were found between polymorphisms of CYP1A1, CYP1B1, CYP2A6, CYP2E1, GSTM1, GSTP1, and EPHX and ESCC (P > 0.05. Conclusion Our results demonstrated that dietary and environmental exposures, some demographic parameters and genetic polymorphism of GSTT1 may play important roles in the development of ESCC in Huaian

  13. Safety for Your Child: 10 Years

    ... Stages Listen Español Text Size Email Print Share Safety for Your Child: 10 Years Page Content Article ... out if your child's friends carry guns. Sports Safety At this age your child may be playing ...

  14. PBL – Reflections after 10 years

    Soler, José

    The poster describes course 34357 at DTU, where PBL has been used in the last 10 years. While the course responsibles where not aware initially that the used methodology was PBL, the poster describes the triggering idea for the initial taken choices, i.e. homogenize working methodologies for...

  15. Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up

    Elferink Marloes AG

    2007-10-01

    Full Text Available Abstract Background The standard treatment of the axilla in breast cancer used to be an axillary lymph node dissection. An axillary lymph node dissection is known to give substantial risks of morbidity. In recent years the sentinel node biopsy has become common practice. Future randomized study results will determine whether the expected decrease in morbidity can be proven. Methods Before the introduction of the sentinel node biopsy, we conducted a study in which 180 women of 50 years and older with T1/T2 cN0 breast cancer were treated with breast conserving therapy. Instead of an axillary lymph node dissection regional radiotherapy was given in combination with tamoxifen (RT-group. The study group was compared with 341 patients, with the same patient and tumour characteristics, treated with an axillary lymph node dissection (S-group. Results The treatment groups were comparable, except for age. The RT-group was significantly older than the S-group. The median follow up was 7.2 years. The regional relapse rates were low and equal in both treatment groups, 1.1% in RT-group versus 1.5% in S-group at 5 years. The overall survival was similar; the disease free survival was significant better in the RT-group. Conclusion Regional recurrence rates after regional radiotherapy are very low and equal to an axillary lymphnode dissection.

  16. Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up

    The standard treatment of the axilla in breast cancer used to be an axillary lymph node dissection. An axillary lymph node dissection is known to give substantial risks of morbidity. In recent years the sentinel node biopsy has become common practice. Future randomized study results will determine whether the expected decrease in morbidity can be proven. Before the introduction of the sentinel node biopsy, we conducted a study in which 180 women of 50 years and older with T1/T2 cN0 breast cancer were treated with breast conserving therapy. Instead of an axillary lymph node dissection regional radiotherapy was given in combination with tamoxifen (RT-group). The study group was compared with 341 patients, with the same patient and tumour characteristics, treated with an axillary lymph node dissection (S-group). The treatment groups were comparable, except for age. The RT-group was significantly older than the S-group. The median follow up was 7.2 years. The regional relapse rates were low and equal in both treatment groups, 1.1% in RT-group versus 1.5% in S-group at 5 years. The overall survival was similar; the disease free survival was significant better in the RT-group. Regional recurrence rates after regional radiotherapy are very low and equal to an axillary lymphnode dissection

  17. Spatial comparison of areas at risk for schistosomiasis in the hilly and mountainous regions in the People’s Republic of China: evaluation of the long-term effect of the 10-year World Bank Loan Project

    Zhi-Jie Zhang

    2012-05-01

    Full Text Available The long-term effectiveness of the mainly chemotherapy-based control strategy of the World Bank Loan Project (WBLP for schistosomiasis control in Chinese hilly and mountainous regions was evaluated with a view to determine the best road forward. Based on the national database of schistosomiasis prevalence for the periods of 1999-2001 and 2007- 2008 in the People’s Republic of China, a Bayesian regression model was used for spatial comparison of schistosomiasis risk distribution between two periods taking account of all the potential risk factors simultaneously through two latent components of random effects: spatially correlated heterogeneities (CH and spatially uncorrelated heterogeneities (UH. Four different types of endemic areas were investigated: those that remained endemic despite control efforts (17 or 37.8%, those that became non-endemic (9 or 20.0%, those that reverted back to endemicity (7 or 15.6%, and those with fluctuating endemicity (12 or 26.7%. The overall prevalence of schistosomiasis was lower in 2007-2008 compared with that in 1999- 2001, but the spatial distribution of risk remained similar. Compared to 1999-2001, the magnitude and range of risk even tended to be greater in 2007-2008. UH showed a fluctuating pattern, while CH increased gradually doubling over the two periods. There was no evidence for long-term effectiveness of the WBLP chemotherapy-based control strategy in this region. Controlling the effect of UH is still the main aspect of current schistosomiasis control strategy for the hilly and mountainous regions, but innovative methods are urgently needed for effectively controlling UH.

  18. Spatial comparison of areas at risk for schistosomiasis in the hilly and mountainous regions in the People's Republic of China: evaluation of the long-term effect of the 10-year World Bank Loan Project.

    Zhang, Zhi-Jie; Zhu, Rong; Bergquist, Robert; Chen, Dong-Mei; Chen, Yue; Zhang, Li-Juan; Guo, Jia-Gang; Zhao, Fei; Jiang, Qing-Wu

    2012-05-01

    The long-term effectiveness of the mainly chemotherapy-based control strategy of the World Bank Loan Project (WBLP) for schistosomiasis control in Chinese hilly and mountainous regions was evaluated with a view to determine the best road forward. Based on the national database of schistosomiasis prevalence for the periods of 1999-2001 and 2007-2008 in the People's Republic of China, a Bayesian regression model was used for spatial comparison of schistosomiasis risk distribution between two periods taking account of all the potential risk factors simultaneously through two latent components of random effects: spatially correlated heterogeneities (CH) and spatially uncorrelated heterogeneities (UH). Four different types of endemic areas were investigated: those that remained endemic despite control efforts (17 or 37.8%), those that became non-endemic (9 or 20.0%), those that reverted back to endemicity (7 or 15.6%), and those with fluctuating endemicity (12 or 26.7%). The overall prevalence of schistosomiasis was lower in 2007-2008 compared with that in 1999-2001, but the spatial distribution of risk remained similar. Compared to 1999-2001, the magnitude and range of risk even tended to be greater in 2007-2008. UH showed a fluctuating pattern, while CH increased gradually doubling over the two periods. There was no evidence for long-term effectiveness of the WBLP chemotherapy-based control strategy in this region. Controlling the effect of UH is still the main aspect of current schistosomiasis control strategy for the hilly and mountainous regions, but innovative methods are urgently needed for effectively controlling UH. PMID:22639122

  19. Increase in sickness absence with psychiatric diagnosis in Norway: a general population-based epidemiologic study of age, gender and regional distribution

    Brage Sören

    2006-08-01

    Full Text Available Abstract Background The aim of this study was to assess the incidence of sickness absence with psychiatric diagnoses from 1994–2000, and the distribution across gender, age groups, diagnostic groups and regions in a general population. Methods The population at risk was defined as all individuals aged 16–66 years who were entitled to sickness benefits in 1994, 1996, 1998 and 2000 (n = 2,282,761 in 2000. All individuals with a full-time disability pension were excluded. The study included approximately 77% of the Norwegian population aged 16–66 years. For each year, the study base started on 1 January and ended on 31 December. Individuals that were sick-listed for more than 14/16 consecutive days with a psychiatric diagnosis on their medical certificate were selected as cases. Included in this study were data for Norway, the capital city Oslo and five regions in the southeast of the country. Results Sickness absence with psychiatric diagnoses increased in all age groups, in women and men, and in all regions. At the national level, the cumulative incidence increased in women from 1.7% in 1994 to 4.6% in 2000, and in men from 0.8% in 1994 to 2.2% in 2000. The highest cumulative incidence was found in middle-aged women and men (30–59 years. Women had a higher incidence than men in all stratification groups. The cumulative incidences in 2000 varied between 4.6% to 5.6% in women in the different regions, and for men the corresponding figures were 2.1% to 3.2%. Throughout the four years studied, women in Oslo had more than twice as high incidence levels of sickness absence with alcohol and drug diagnoses as the country as a whole. There were some differences between regions in sickness absence with specific psychiatric diagnoses, but they were small and most comparisons were non-significant. Conclusion Sickness absence with psychiatric diagnoses increased between 1994 and 2000 in Norway. The increase was highest in the middle-aged, and in women

  20. Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

    Gao Weimin; Hu Xu; Wang Shaokang; Xie Yin; Tang Yuntian; Sun Guiju; Tang Lili; Wang Zemin; Cox Stephen B; Wang Jia-Sheng

    2006-01-01

    Abstract Background Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is one of the endemic regions of ESCC, but fewer studies have been done in characterizing the risk factors of ESCC in this area. The aims of this study is to evaluate the etiological roles of demographic parameters, environmental and fo...

  1. 10-Year Observation of Bullous Pemphigoid Patients

    Bengu Nisa Akay

    2010-06-01

    Full Text Available Background and Design: Bullous pemphigoid (BP is an autoimmune skin disorder characterized by large, tense blisters of the skin. It occurs mainly in the elderly. The one year mortality associated with bullous pemphigoid ranges from 19% to 41%. We aim to analyse the etiologic factors, demographic features, clinical course and response to treatment in patients with BP. Material and Method: Between January 1999 and January 2008, 31 patients with BP were evaluated retrospectively. We assessed duration of the disease, presence of associated symptoms, clinical findings, drug intake, response to treatment, recurrence rates and also extensive laboratory testing and radiologic evaluations on each patient to clarify a possible underlying malignancy. Results: In a 10-year period, 31 patients with BP, female male ratio was 19/12, ranging in age from 59 to 96 (mean 78.8±8.67 years were evaluated. Duration of the disease was 16.58±18.48 months. Direct immunoflourescence of the perilesional skin showed linear deposition of IgG and C3 along the dermoepidermal junction in 24 patients (77.4%. There was no significant relationship between drug usage and bullous pemphigoid. No malignancy was detected. Medium dosage of prednisolone (50-60 mg/day was the first choice of treatment in 8 patients with a complete response rate in all but two patients died during therapy. Four patients died during hospitalization with unknown reasons before any treatment was started. In 16 cases the initial treatment was prednisolone and azathioprine. The mean follow-up period was 12 months and 11 (35% cases had relapsed. The longest remission was achieved with prednisolone and azathioprine combination. Conclusion: In conclusion, no association was found between BP and drug usage or malignancy. All patients responded well to treatment. Therapy with prednisone maintained with azathiopyrine significantly reduced the recurrences. However, disease-specific mortality is found to be high and

  2. Genetic structure of Afghan Pika (Ochotona rufescens populations based on D-loop region of the mitochondrial genome in Northern Khorasan Province

    Olyagholi Khalilipour

    2014-12-01

    Full Text Available This study was carried out for genetic diversity of Afghan Pika (Ochotona rufescens among four different populations in Northern Khorasan Province using D-Loop region of mitochondrial gene. The sixteen specimens were trapped from four different sanctuaries (Ghorkhod, Golol-Sarani, Salouk and Sarigol and transferred to Laboratory. The intra and inter population genetic factors (haplotype and nucleotide diversity, haplotype differentiation among populations, Fst, Nm, gamma distribution parameter, mismatch distribution, Tajima'D neutrality test and Isolation by distance were estimated and the results were compared among the populations. Finally, data set with 483 bp was used for each individual. The results showed 25 polymorphic, 457 conserved sites and 10 different haplotypes. The low value of Fst (Fst=0.21, P0.5 and Tajima 'D test (0.37, P>0.1 showed no population expansion and relatively stable population sizes.

  3. Body Dissatisfaction from Adolescence to Young Adulthood: Findings from a 10-Year Longitudinal Study

    Bucchianeri, Michaela M.; Arikian, Aimee J.; Hannan, Peter J.; Eisenberg, Marla E.; Neumark-Sztainer, Dianne

    2012-01-01

    Given mixed findings regarding the unique trajectories of female and male adolescents’ body dissatisfaction over time, comprehensive longitudinal examinations are needed. This 10-year longitudinal, population-based study, with 1,902 participants from diverse ethnic/racial and socioeconomic backgrounds in the Minneapolis/St. Paul metropolitan area, examined changes in body dissatisfaction from adolescence to young adulthood. Results revealed that: (a) female and male participants’ body dissati...

  4. Modelling the force of infection for hepatitis A in an urban population-based survey: a comparison of transmission patterns in Brazilian macro-regions.

    Ricardo Arraes de Alencar Ximenes

    Full Text Available BACKGROUND: This study aimed to identify the transmission pattern of hepatitis A (HA infection based on a primary dataset from the Brazilian National Hepatitis Survey in a pre-vaccination context. The national survey conducted in urban areas disclosed two epidemiological scenarios with low and intermediate HA endemicity. METHODS: A catalytic model of HA transmission was built based on a national seroprevalence survey (2005 to 2009. The seroprevalence data from 7,062 individuals aged 5-69 years from all the Brazilian macro-regions were included. We built up three models: fully homogeneous mixing model, with constant contact pattern; the highly assortative model and the highly assortative model with the additional component accounting for contacts with infected food/water. Curves of prevalence, force of infection (FOI and the number of new infections with 99% confidence intervals (CIs were compared between the intermediate (North, Northeast, Midwest and Federal District and low (South and Southeast endemicity areas. A contour plot was also constructed. RESULTS: The anti- HAV IgG seroprevalence was 68.8% (95% CI, 64.8%-72.5% and 33.7% (95% CI, 32.4%-35.1% for the intermediate and low endemicity areas, respectively, according to the field data analysis. The models showed that a higher force of infection was identified in the 10- to 19-year-old age cohort (∼9,000 infected individuals per year per 100,000 susceptible persons in the intermediate endemicity area, whereas a higher force of infection occurred in the 15- to 29-year-old age cohort (∼6,000 infected individuals per year per 100,000 susceptible persons for the other macro-regions. CONCLUSION: Our findings support the shift of Brazil toward intermediate and low endemicity levels with the shift of the risk of infection to older age groups. These estimates of HA force of infection stratified by age and endemicity levels are useful information to characterize the pre-vaccination scenario in

  5. Developing of 10-year EEZ seafloor mapping and research program

    Lockwood, M.; Hill, G.W.

    1988-01-01

    The intent of expanding the exploration already begun on the outer continental shelf to the frontier of the EEZ (Exclusive Economic Zone) is to determine the "characteristics' and resource potential of this region. To coordinate this exploration, a Joint Office for Mapping and Research (JOMAR) has been established by the US Geological Survey (in the Department of the Interior) and the National Oceanic and Atmospheric Administration (in the Department of Commerce). JOMAR's main purpose is to help direct and coordinate ongoing and planned seafloor related activities in the EEZ and prepare a 10-year plan for mapping and research. -from Authors

  6. A 10 YEAR SURVEY ON CHILDHOOD CNS TUMORS

    F. Jadali

    2008-06-01

    Full Text Available ObjectiveTumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. The main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of CNS tumors in children, less than 15 years of age, in the Mofid Children’s Hospital, in the past 10 years.Materials and Methods In this descriptive retrospective study we reviewed the medical records of 143children with diagnosis of CNS tumors admitted during the past 10 years in neurology and surgery departments of Mofid Children’s Hospital between the years 1996 and 2006.ResultsDuring the 10 year study period, CNS tumor was diagnosed in 143 patients; of these tumors, 119 were intracranial and 58 were intraspinal; 51.3% of brain tumors were located in the supratentorial and 48.7% in the infratentorial regions. The most common intracranial neoplasms were astrocytic tumors (36.8%, embryonal tumors (31.1% and ependymal tumors (13.4%. Of the intraspinal neoplasms the most frequently noted were embryonal tumors (37.5%, mesenchymal meningothelial tumors (20.8%, followed by astrocytic tumors (16.7%. The median age at diagnosis was 8.9 ± 4.1 years with a male to female ratio of 1.4:1 (P<0.5. The most common intracranial astrocytic and embryonal neoplasms were pilocytic astrocytoma and medulloblastoma / PNET respectively.ConclusionBrain tumors in children constitute a diverse group in terms of incidence, distribution and histopathological diagnosis.

  7. A 10 YEAR SURVEY ON CHILDHOOD CNS TUMORS

    F. Jadali

    2008-10-01

    Full Text Available AbstractObjectiveTumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. The main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of CNS tumors in children, less than 15 years of age, in the Mofid Children's Hospital, in the past 10 years. Materials and MethodsIn this descriptive retrospective study we reviewed the medical records of 143 children with diagnosis of CNS tumors admitted during the past 10 years in neurology and surgery departments of Mofid Children's Hospital between the years 1996 and 2006.ResultsDuring the 10 year study period, CNS tumor was diagnosed in 143 patients; of these tumors, 119 were intracranial and 58 were intraspinal; 51.3% of brain tumors were located in the supratentorial and 48.7% in the infratentorial regions. The most common intracranial neoplasms were astrocytic tumors (36.8%, embryonal tumors (31.1% and ependymal tumors (13.4%. Of the intraspinal neoplasms the most frequently noted were embryonal tumors(37.5%, mesenchymal meningothelial tumors (20.8%, followed by astrocytic tumors (16.7%. The median age at diagnosis was 8.9 ± 4.1 years with a male to female ratio of 1.4:1 (P Conclusion Brain tumors in children constitute a diverse group in terms of incidence,distribution and histopathological diagnosis.Keywords: CNS tumors, Histopathology, Children.

  8. The effects of 10 years Railway investment in Denmark

    Hansen, Sten A.

    1998-01-01

    The paper retrives the impacts of the last 10 years of investment in railway infrastructure in Denmark and ooncludes, that traveltimes and frequency is large unchanged during that period.......The paper retrives the impacts of the last 10 years of investment in railway infrastructure in Denmark and ooncludes, that traveltimes and frequency is large unchanged during that period....

  9. METEONETWORK: 2002-2012, 10 years of activities

    Mazza, Edoardo

    2013-04-01

    The role of citizen-scientists in collecting data and observations has been increasingly crucial in the last 10 years of atmospheric sciences. Meteonetwork is a non-profit organization founded by citizen scientists in 2002, in Lombardia, with the aim of raising public awareness about meteorological and climatological issues. Throughout the years the organization, besides the continuous holding of events such as meeting, conferences and talks, has been standing out because of its forum and its wide network of weather stations. Meteonetwork's forum is, in this field, the most read and followed in the country and with its 8459 members and over 4,217,505 posts turns out to be the 17th forum over the entire country. Its network is operated in cooperation with Centro Epson Meteo and collects amateur semi-professional stations distributed all over the Italian territory, providing real-time and daily data. It consists of 706 stations, among which more than 400 regularly updated; volunteers constantly work to perform quality control and ensure data reliability. Meteonetwork has also developed several collaborations with private and public institutions, among which DRIHM - Cima Research Foundation, Centro Epson Meteo di Milano, Arpa Veneto, Arpa Emilia-Romagna, Arpa Lombardia, Arpa Friuli - Venezia Giulia, Servizio Glaciologico Lombardo, C. N. R. - C. I. S. A, Università di Pisa, Università di Milano, University of Aberdeen, Protezione Civile - Regione Lombardia, Protezione Civile - Regione Piemonte stand out. As WMO emphasized in 2001 World Meteorological Day "Volunteers for the weather, climate and water" the contribution of citizen-scientists to scientific studies is remarkable. In this perspective Meteonetwork and the University of Milan, in April 2011, started a project of technical and scientific cooperation called Weatherness. The university is provided with data gathered by Meteoneonetwork's stations with the aim of improving the knowledge of the impact that heat

  10. The gender- and age-specific 10-year and lifetime absolute fracture risk in Tromso, Norway

    Aim of this study is to estimate the gender- and age-specific 10-year and lifetime absolute risks of non-vertebral and osteoporotic (included hip, distal forearm and proximal humerus) fractures in a large cohort of men and women. This is a population-based 10 years follow-up study of 26,891 subjects aged 25 years and older in Tromso, Norway. All non-vertebral fractures were registered from 1995 throughout 2004 by computerized search in radiographic archives. Absolute risks were estimated by life-table method taking into account the competing risk of death. The absolute fracture risk at each year of age was estimated for the next 10 years (10-year risk) or up to the age of 90 years (lifetime risk). The estimated 10-year absolute risk of all non-vertebral fracture was higher in men than women before but not after the age of 45 years. The 10-year absolute risk for non-vertebral and osteoporotic fractures was over 10%, respectively, in men over 65 and 70 years and in women over 45 and 50 years of age. The 10-year absolute risks of hip fractures at the age of 65 and 80 years were 4.2 and 18.6% in men, and 9.0 and 24.0% in women, respectively. The risk estimates for distal forearm and proximal humerus fractures were under 5% in men and 13% in women. The estimated lifetime risks for all fracture locations were higher in women than men at all ages. At the age of 50 years, the risks were 38.1 and 24.8% in men and 67.4 and 55.0% in women for all non-vertebral and osteoporotic fractures, respectively. The estimated gender- and age-specific 10-year and lifetime absolute fracture risk were higher in Tromso than in other populations. The high lifetime fracture risk reflects the increased burden of fractures in this cohort

  11. ESO and Chile: 10 Years of Productive Scientific Collaboration

    2006-06-01

    ceremony, along with ambassadors in Chile of ESO members States, and representatives of the Chilean government and the scientific community. To review the impact of the numerous projects financed over the last decade, ESO presented the book "10 Years Exploring the Universe", based on the reports of the beneficiaries of the ESO-Chile fund. Since the beginning, the ESO-Chile fund has granted over 2.5 million euros to finance post-doc and astronomy professors for main Chilean universities, development of research infrastructure, organisation of scientific congresses, workshops for science teachers, and astronomy outreach programmes for the public. In addition to the 400,000 euros given annually by ESO to the ESO-Chile Joint Committee, around 550,000 euros are granted every year to finance regional collaboration programmes, fellowships for students in Chilean universities, and the development of radio astronomy through the ALMA-Chile Committee. In total, apart form the 10 percent of the observing time at all ESO telescopes, ESO contributes annually with 950,000 euros for the promotion of astronomy and scientific culture in Chile. The growth of astronomy and related sciences in Chile in the last years has been outstanding. According to a study by the Chilean Academy of Science in 2005, the number of astronomers has doubled over the last 20 years and there has been an 8-fold increase in the number of scientific publications. It is gratifying to see that 100 percent of the observing time granted by international observatories in Chile is actually used by the national community. The same study stated that astronomy could be the first scientific discipline in Chile with the standards of a developed country, with additional benefits in terms of technological improvement and growth of human resources. The English edition of the book "10 Years Exploring the Universe" is available here. The Spanish edition can be downloaded here.

  12. Incidence of neural tube defects in liveborn and stillborn infants in British Columbia over a 10-year period.

    A.D. Sadovnick; Baird, P. A.

    1983-01-01

    Reports of an apparent decline in the incidence of neural tube defects (NTDs) have come from various parts of the world. If these findings are consistent they would have an important impact on prenatal diagnosis and on screening programs. The incidence of NTDs over a 10-year period was examined in British Columbia, a province that has a population-based health surveillance registry through which there is virtually complete ascertainment of liveborn infants with NTDs. The results showed a sign...

  13. Non-participation in breast cancer screening for persons with chronic diseases and multimorbidity: a population-based cohort study

    Andersen, Berit

    2015-01-01

    Background Chronic diseases and multimorbidity are common in western countries and associated with increased breast cancer mortality. This study aims to investigate non-participation in breast cancer screening among women with chronic diseases and multimorbidity and the role of time in this...... association. Method This population-based cohort study used regional and national registries. Women who were invited to the first breast cancer screening round in the Central Denmark Region in 2008–09 were included (n = 149,234). Selected chronic diseases and multimorbidity were assessed up to 10 years before...... the screening date. Prevalence ratios (PR) were used as an association measure. Results The results indicated that women with at least one chronic condition were significantly more likely not to participate in breast cancer screening. In adjusted analysis, a significantly higher likelihood of non...

  14. Duodenal adenocarcinoma in a 10-year-old boy

    Zouari Mohamed

    2014-01-01

    Full Text Available Gastrointestinal malignancies are extremely rare in the paediatric population and duodenal cancers represent an even more unusual entity. It represents 0.3-1% of all gastrointestinal tumours. A case report of a 10-year-old boy with duodenal adenocarcinoma is reported and the difficulties of diagnosing and treating this rare tumour are discussed.

  15. Duodenal adenocarcinoma in a 10-year-old boy.

    Mohamed, Zouari; Habib, Bouthour; Rabia, Ben Abdallah; Youssef, Hlel; Riath, Ben Malek; Youssef, Gharbi; Nejib, Kaabar

    2014-01-01

    Gastrointestinal malignancies are extremely rare in the paediatric population and duodenal cancers represent an even more unusual entity. It represents 0.3-1% of all gastrointestinal tumours. A case report of a 10-year-old boy with duodenal adenocarcinoma is reported and the difficulties of diagnosing and treating this rare tumour are discussed. PMID:24647303

  16. Highlights of 10-Year Remote Sensing Industry Analysis

    Rabin, Ron

    2002-01-01

    A background and highlights of a 10 year remote sensing industry analysis are provided.Included are the following:Training, educational analysis, staff levels, and end-users analysis, market drivers, market segments,application areas, spatial resolution needs, use of image types.

  17. After Cotton Prices Hit a 10-Year Peak...

    Wang Zhaofeng

    2010-01-01

    @@ "With the fifth-grade seed cotton being priced at 4.5 yuan per 500 grams and Xinjiang lint cotton at nearly RMB 20,000 per ton, cotton prices have rocketed to a 10-year peak," Gap Chaoshan, President of the Liaocheng Cotton Association, told the reporter on September 26.

  18. Peritoneal dialysis in an ageing population: a 10-year experience.

    Smyth, Andrew

    2012-02-01

    Chronic kidney disease (CKD) is becoming increasingly prevalent and there are increasing numbers of older patients with advanced CKD. Peritoneal dialysis (PD) is a potential treatment. This study aims to compare PD outcomes in age-defined populations in the largest PD centre in the Republic of Ireland over 10 years.

  19. Tracheobronchial foreign body in children - 10 years experience

    Balica, NC; Poenaru, M; Marin, AH; Iovanescu, G; Stefanescu, HE; Boia, ER; Doros, C

    2015-01-01

    Introduction: Presentation of ENT Department - Timisoara 10 years experience of in the diagnosis and treatment of tracheobronchial foreign body in children. We studied 93 children, aged between 10 months and 8 years.Methods: The diagnosis of airways penetrating syndrome was established on history, clinical examination, cardiopulmonary X-ray, CT (virtual bronchoscopy) and rigid videotracheobronhoscopy. Foreign body removal was performed using pediatric Karl-Storz tracheobronhoscopy kit, unde...

  20. Primary Nasal Tuberculosis in a 10-Year-Old Girl

    Özer, Murat; Özsurekçi, Yasemin; Cengiz, Ali Bülent; Özçelik, Uğur; Yalçın, Ebru; Gököz, Özay

    2016-01-01

    Nasal tuberculosis is a rare clinical entity which mainly presents in elderly people. Nasal tuberculosis has always been considered to be secondary to tuberculosis of the lungs, and in rare instances it is a primary infection, usually when mycobacteria are inhaled. We describe the case of a 10-year-old girl who was successfully treated for primary nasal tuberculosis. This patient is one of the very few children who have been reported to have primary nasal tuberculosis. PMID:27366187

  1. Mistakes in diagnosing non-accidental injury: 10 years' experience

    Wheeler, David M; Hobbs, Christopher J

    1988-01-01

    Fifty children who were referred to the child abuse team in Leeds over the 10 years 1976-86 with suspected non-accidental injury were found to have conditions which mimicked non-accidental injury. These included impetigo (nine children) and blue spots (five children). Five children who presented with multiple bruising had haemostatic disorders. Eight children had disorders of the bone. Five children had been previously abused physically. Four showed evidence of neglect. One had evidence of no...

  2. Atypical presentation of macrophagic myofasciitis 10 years post vaccination.

    Ryan, Aisling M

    2012-02-03

    Macrophagic myofasciitis (MMF) is an uncommon inflammatory disorder of muscle believed to be due to persistence of vaccine-derived aluminium hydroxide at the site of injection. The condition is characterised by diffuse myalgias, arthralgia and fatigue. We describe a patient with histologically confirmed MMF whose presentation was atypical with left chest and upper limb pain beginning more than 10 years post vaccination. Treatment with steroids led to symptomatic improvement. Although rare, clinicians should consider MMF in cases of atypical myalgia.

  3. Endometrial stem/progenitor cells: the first 10 years

    Gargett, Caroline E; Schwab, Kjiana E.; Deane, James A

    2015-01-01

    BACKGROUND The existence of stem/progenitor cells in the endometrium was postulated many years ago, but the first functional evidence was only published in 2004. The identification of rare epithelial and stromal populations of clonogenic cells in human endometrium has opened an active area of research on endometrial stem/progenitor cells in the subsequent 10 years. METHODS The published literature was searched using the PubMed database with the search terms ‘endometrial stem cells and menstru...

  4. Perceived Partner Responsiveness Predicts Diurnal Cortisol Profiles 10 Years Later

    Slatcher, Richard B.; Selcuk, Emre; Ong, Anthony D.

    2015-01-01

    Several decades of research have demonstrated that marital relationships have a powerful influence on physical health. However, surprisingly little is known about how marriage affects health—both in terms of psychological processes and biological ones. We investigated the associations between perceived partner responsiveness—the extent to which people feel understood, cared for and appreciated by their romantic partner—and diurnal cortisol over a 10-year period in a large sample of married an...

  5. Natural 10-year history of simple renal cysts

    Park, Hongzoo; Kim, Choung-Soo

    2015-01-01

    Purpose To carry out long-term follow-up of patients diagnosed with asymptomatic simple renal cysts (SRCs). Materials and Methods One hundred fifty-eight adult patients in whom SRCs were incidentally diagnosed by abdominal ultrasonography or abdominopelvic computed tomography between August 1994 and June 2004 were followed up for over 10 years. The retrospective analysis investigated sequential changes in the size, shape, and Bosniak classification of the renal cyst and analyzed risk factors ...

  6. Mild Traumatic Brain Injuries : A 10-year follow-up

    Elgmark Andersson, Elisabeth; Bedics, Beate Kärrdahl; Falkmer, Torbjörn

    2011-01-01

    Objective and design: Long-term consequences of mild traumatic brain injuries were investigated based on a 10-year follow-up of patients from a previously published randomized controlled study of mild traumatic brain injuries. One aim was to describe changes over time after mild traumatic brain injuries in terms of the extent of persisting post-concussion symptoms, life satisfaction, perceived health, activities of daily living, changes in life roles and sick leave. Another aim was to identif...

  7. Avian response to bottomland hardwood reforestation: the first 10 years

    Twedt, D.J.; Wilson, R.R.; Henne-Kerr, J.L.; Grosshuesch, D.A.

    2002-01-01

    Bttomland hardwood forests were planted on agricultural fields in Mississippi and Louisiana using either predominantly Quercus species (oaks) or Populus deltoides (eastern cottonwood). We assessed avian colonization of these reforested sites between 2 and 10 years after planting. Rapid vertical growth of cottonwoods (circa 2 - 3 m / yr) resulted in sites with forest structure that supported greater species richness of breeding birds, increased Shannon diversity indices, and supported greater territory densities than on sites planted with slower-growing oak species. Grassland birds (Spiza americana [Dickcissel], and Sturnella magna [Eastern Meadowlark]) were indicative of species breeding on oak-dominated reforestation # 10 years old. Agelaius phoeniceus (Red-winged Blackbird) and Colinus virginianus (Northern Bobwhite) characterized cottonwood reforestation # 4 years old, whereas 14 species of shrub-scrub birds (e.g., Passerina cyanea [Indigo Bunting]) and early-successional forest birds (e.g., Vireo gilvus [Warbling Vireo]) typified cottonwood reforestation 5 to 9 years after planting. Rates of daily nest survival did not differ between reforestation strategies. Nest parasitism increased markedly in older cottonwood stands, but was overwhelmed by predation as a cause of nest failure. Based on Partners in Flight prioritization scores and territory densities, the value of cottonwood reforestation for avian conservation was significantly greater than that of oak reforestation during their first 10 years. Because of benefits conferred on breeding birds, we recommend reforestation of bottomland hardwoods include a high proportion of fast-growing, early successional species such as cottonwood.

  8. Early productive vocabulary predicts academic achievement 10 years later

    Bleses, Dorthe; Makransky, Guido; Dale, Philip; Højen, Anders; Aktürk Ari, Burcak

    2016-01-01

    We use a longitudinal design to examine associations for 2,120 16-30 months old children between early expressive vocabulary and later reading and math outcomes in the 6th Grade based on a large and diverse sample of Danish children. Educational outcomes, in particular decoding and reading...... comprehension, can be predicted from an early vocabulary measure as early as 16 months with effect sizes (in proportion of variance accounted for) comparable to one year’s mean growth in reading scores. The findings confirm in a relatively large population based study that late talkers are at risk for later...

  9. IMIE computer codes: 10 years in the internal dosimetry

    Full text: The IMIE ('Individual Monitoring for Internal Exposure') computer codes are the family of interactive tools for interpretation of the bioassay data, individual dose assessments, tracking the history of exposure and documentation of the process of assessment. All members of the 'IMIE family' use the unified graphical interface, the common library of tabulated 'bioassay/dose response functions' and the Paradox database for storage of individual bioassay histories. During 10 years of the IMIE evolution the extensive experience in the IMIE application have been accumulated. Advances in the code development have been made thanks to IAEA and 3rd European Intercomparison Exercises, numerous users' requests and, especially, as a result of interaction in the framework of the IDEAS project aimed to the development of the International Guideline on Interpretation of Bioassay Data as well as to the organization of the 4th European Intercomparison Exercise. The main distinguished feature of the IMIE ideology is the automated numerical analysis of all requested by the user exposure scenarios with the succeeding interactive identification of events of intake(s) and assessment of associated doses. The visualization of data interpretation is based on the interaction with the user by means of interactive plots and tables. The IMIE exploits also the 'dose per unit measured bioassay value' (DPUM) concept, the useful tool for planning of bioassay programs as well as for interpretation of bioassay data. The numerical deconvolution algorithms and the massive library of tabulated 'bioassay/dose response functions' (time-dependent organ activity and excretion rates per unit deposited activity in one of lungs regions or per unit ingested/injected activity; associated committed equivalent doses to organs and the effective dose) are employed for processing of an arbitrary pattern of intake and complex exposure conditions. Nowadays distinguishing features of IMIE are: simultaneous

  10. 10 lessons from 10 years of the CDM

    Shishlov, Igor; Bellassen, Valentin

    2012-01-01

    The Clean Development Mechanism (CDM) is the first and by far the largest carbon offset instrument in the world. To date, it is the only market based on an environmental commodity which managed to attract several billions of euros of private capital on an annual basis. Being the first-of-a-kind climate change mitigation instrument, the CDM followed a "learning by doing" pattern undergoing numerous reforms throughout its more than 10-year history. Although the post-2012 fate of the mechanism r...

  11. ACUTE NON-ORGANIC PSYCHOSIS-OUTCOME AFTER 10 YEARS

    Gupta, L.N.; Bhardwaj, Pramod

    2000-01-01

    62 out of 68 acute psychosis patients who were initially recruited from the Bikaner Centre in 1982 for the Indian Council of Medical Research (ICMR) study on "phenomenology and natural history of acute psychosis" were assessed after completion of 10 years in 1992-93 on SCAAPS and PSE with the objective of studying the long term course and outcome of acute psychosis. The results show that 35 (56.45%) patients of acute brief episode of psychosis never had any psychotic illness during the course...

  12. Motor Speech Disorders: Where Will We Be in 10 Years?

    Duffy, Joseph R

    2016-08-01

    Research and practice in the area of motor speech disorders (MSDs) will change in the next 10 years, most likely in evolutionary rather revolutionary ways. We are likely to see an increase in the understanding of the underpinnings of MSDs and refinements in assessment and diagnosis. Management approaches probably will be refined, as will how outcomes are measured. The evidence base for treatment efficacy will grow. Technology and changes in the health care system will have strong and overarching, but not easily predicted, influences. This article provides a broad overview of these and related issues, with some cautious predictions. PMID:27232096

  13. Prevalence of Frailty Indicators and Association with Socioeconomic Status in Middle-Aged and Older Adults in a Swiss Region with Universal Health Insurance Coverage: A Population-Based Cross-Sectional Study

    Idris Guessous

    2014-01-01

    Full Text Available Frailty prevalence in older adults has been reported but is largely unknown in middle-aged adults. We determined the prevalence of frailty indicators among middle-aged and older adults from a general Swiss population characterized by universal health insurance coverage and assessed the determinants of frailty with a special focus on socioeconomic status. Participants aged 50 and more from the population-based 2006–2010 Bus Santé study were included (N = 2,930. Four frailty indicators (weakness, shrinking, exhaustion, and low activity were measured according to standard definitions. Multivariate logistic regressions were used to determine associations. Overall, 63.5%, 28.7%, and 7.8% participants presented no frailty indicators, one frailty indicator, and two or more frailty indicators, respectively. Among middle-aged participants (50–65 years, 75.1%, 22.2%, and 2.7% presented 0, 1, and 2 or more frailty indicators. The number of frailty indicators was positively associated with age, hypertension, and current smoking and negatively associated with male gender, body mass index, waist-to-hip ratio, and serum total cholesterol level. Lower income level but not education was associated with higher number of frailty indicators. Frailty indicators are frequently encountered in both older and middle-aged adults from the Swiss general population. Despite universal health insurance coverage, household income is independently associated with frailty.

  14. Early productive vocabulary predicts academic achievement 10 years later

    Bleses, Dorthe; Makransky, Guido; Dale, Philip;

    2016-01-01

    comprehension, can be predicted from an early vocabulary measure as early as 16 months with effect sizes (in proportion of variance accounted for) comparable to one year’s mean growth in reading scores. The findings confirm in a relatively large population based study that late talkers are at risk for later......We use a longitudinal design to examine associations for 2,120 16-30 months old children between early expressive vocabulary and later reading and math outcomes in the 6th Grade based on a large and diverse sample of Danish children. Educational outcomes, in particular decoding and reading...... educational attainment as the majority of children experiencing early language delay obtain scores below average in measures of reading in the 6th Grade. Low scores have the greatest predictive power indicating that children with early delays have elevated risk for later reading problems....

  15. Natural History of Irritable Bowel Syndrome in Women and Dysmenorrhea: A 10-Year Follow-Up Study

    Linda Bjork Olafsdottir; Hallgrimur Gudjonsson; Heidur Hrund Jonsdottir; Einar Björnsson; Bjarni Thjodleifsson

    2012-01-01

    Background. Studies have shown that women are more likely to have irritable bowel syndrome (IBS) and more women seek healthcare because of IBS than men. Aim. We wanted to examine the natural history of IBS and dysmenorrhea in women over a 10-year period and to assess the change in IBS after menopause. Method. A population-based postal study. A questionnaire was mailed to the same age- and gender-stratified random sample of the Icelandic population aged 18–75 in 1996 and again in 2006. Results...

  16. Clavicle nonunion in a 10-year-old boy.

    Pourtaheri, Neema; Strongwater, Allan M

    2012-03-01

    Posttraumatic clavicle nonunion is rare, particularly in children. Four cases of clavicle fracture nonunion in patients aged 10 years and younger have been reported. A variety of techniques have been used to treat pediatric clavicle nonunions. A 10-year-old boy presented to our institution after a fall, sustaining a right closed midshaft clavicle fracture. No other injuries occurred, and neurovascular examination of the right upper extremity was normal. The fracture was initially treated with a sling for >4 months, and the fracture progressed to a hypertrophic nonunion. Serial radiographs failed to demonstrate progression to union. The patient continued to have pain with activity 4 months after his injury. Clavicle pseudarthrosis was considered; however, radiographs did not have the characteristic appearance of this condition. This fracture nonunion was treated with internal fixation and united with no complication. The patient was back to full activities of daily living 6 months postoperatively. He reported no tenderness at the fracture site or along the hardware. The treating surgeon (A.M.S.) prefers to remove hardware in young children, but the family declined removal. Pediatric posttraumatic nonunion of the clavicle is rare but can be safely treated with plate fixation, with excellent results. PMID:22385461

  17. Adherence to oral anticoagulants in patients with atrial fibrillation—a population-based retrospective cohort study linking health information systems in the Valencia region, Spain: a study protocol

    Sanfélix-Gimeno, G; Rodríguez-Bernal, C L; Hurtado, I; Baixáuli-Pérez, C; Librero, J; Peiró, S

    2015-01-01

    Introduction Adherence to oral anticoagulation (OAC) treatment, vitamin K antagonists or new oral anticoagulants, is an essential element for effectiveness. Information on adherence to OAC in atrial fibrillation (AF) and the impact of adherence on clinical outcomes using real-world data barely exists. We aim to describe the patterns of adherence to OAC over time in patients with AF, estimate the associated factors and their impact on clinical events, and assess the same issues with conventional measures of primary and secondary adherence—proportion of days covered (PDC) and persistence—in routine clinical practice. Methods and analysis This is a population-based retrospective cohort study including all patients with AF treated with OAC from 2010 to date in Valencia, Spain; data will be obtained from diverse electronic records of the Valencia Health Agency. Primary outcome measure: adherence trajectories. Secondary outcomes: (1) primary non-adherence; (2) secondary adherence: (a) PDC, (b) persistence. Clinical outcomes: hospitalisation for haemorrhagic or thromboembolic events and death during follow-up. Analysis: (1) description of baseline characteristics, adherence patterns (trajectory models or latent class growth analysis models) and conventional adherence measures; (2) logistic or Cox multivariate regression models, to assess the associations between adherence measures and the covariates, and logistic multinomial regression models, to identify characteristics associated with each trajectory; (3) Cox proportional hazard models, to assess the relationship between adherence and clinical outcomes, with propensity score adjustment applied to further control for potential confounders; (4) to estimate the importance of different healthcare levels in the variations of adherence, logistic or Cox multilevel regression models. Ethics and dissemination This study has been approved by the corresponding Clinical Research Ethics Committee. We plan to disseminate the

  18. Representativeness in population-based studies

    Drivsholm, Thomas Bo; Eplov, Lene Falgaard; Davidsen, Michael;

    2006-01-01

    Decreasing rates of participation in population-based studies increasingly challenge the interpretation of study results, in both analytic and descriptive epidemiology. Consequently, estimates of possible differences between participants and non-participants are increasingly important for the...... interpretation of study results and generalization to the background population....

  19. Organism natural resistance in the liquidators 10 years after Chernobyl accident

    The study involved 95 liquidators (residents of Kyiv and Kyiv region) 10 years after Chernobyl accident clean-up. Leukocyte count was estimated using a generally accepted technique, the amount of large granule-containing lymphocytes (LGL) was determined in the blood smears, natural killer activity was evaluated with radiometric technique. Complex treatment with intravascular laser irradiation and Enterosgel enterosorbent administration increases LGL amount, which provides antitumor and anti-infection protection of the organism

  20. Dual Sensory Impairment in Older Adults Increases the Risk of Mortality: A Population-Based Study

    Gopinath, Bamini; Schneider, Julie; Catherine M McMahon; Burlutsky, George; Leeder, Stephen R; Mitchell, Paul

    2013-01-01

    Although concurrent vision and hearing loss are common in older adults, population-based data on their relationship with mortality is limited. This cohort study investigated the association between objectively measured dual sensory impairment (DSI) with mortality risk over 10 years. 2812 Blue Mountains Eye Study participants aged 55 years and older at baseline were included for analyses. Visual impairment was defined as visual acuity less than 20/40 (better eye), and hearing impairment as ave...

  1. Eating Behavior and Childhood Overweight Among Population-Based Elementary Schoolchildren in Japan

    Akatsuki Kokaze; Naoko Tajima; Hiromi Hoshino; Masayasu Hashimoto; Aya Morimoto; Naoki Shimada; Tadahiro Ohtsu; Hirotaka Ochiai; Takako Shirasawa; Rimei Nishimura

    2012-01-01

    This study investigated the relationship between eating behavior and childhood overweight among population-based elementary schoolchildren in Japan. Data was collected from fourth graders (9 or 10 years of age) from Ina Town, Saitama Prefecture, Japan from 1999 to 2009. Information about subjects’ sex, age, and lifestyle, including eating behaviors (eating until full and chewing thoroughly), was obtained using a self-administered questionnaire, and height and weight were measured directly. Ov...

  2. Omental infarction in an obese 10-year-old boy

    Katerina Kambouri

    2011-09-01

    Full Text Available Primary omental infarction (POI has a low incidence worldwide, with most cases occurring in adults. This condition is rarely considered in the differential diagnosis of acute abdominal pain in childhood. Herein, we present a case of omental infarction in an obese 10-year-old boy who presented with acute abdominal pain in the right lower abdomen. The ultrasound (US examination did not reveal the appendix but showed secondary signs suggesting acute appendicitis. The child was thus operated on under the preoperative diagnosis of acute appendicitis but the intraoperative finding was omental infarct. Since the omental infarct as etiology of acute abdominal pain is uncommon, we highlight some of the possible etiologies and emphasize the importance of accurate diagnosis and appropriate treatment of omental infarction.

  3. Cystic fibrosis school for 10-year-olds

    Bregnballe, Vibeke; Schiøtz, Peter Oluf

    2000-01-01

    children about the respiratory system in CF. They take physiotherapi together and go to the swimmingpool. The dietician and the nurse teach the children about the digestive system in CF and they cook together. The children learn about genetics, liver problems, infertility etc from the doctor and the nurse...... which they can make their own choices in order to improve their quality of life. In practical terms we make classes of 4-8 10-year-old children with CF. We give them 6 lessons of 3 hours. One lesson every second month. The lessons substitute a monthly visit. The psysiotherapist and the nurse teach the....... In the last lesson the psychologist and the nurse talk with the children about taking over the responsibility. The children enjoy being together and learn a lot from each other. It is our belief that if we help the patients to improve knowledge, to cope with the disease and to take over the...

  4. Parathyroid Carcinoma in a 10 Years Old Female Child.

    Rahman, M M; Karim, S S; Joarder, A I; Mubin, S; Abir, M M; Morshed, M S

    2015-07-01

    Parathyroid carcinoma (PC) is a rare cause of hypercalcaemia in children. Only 7 cases of PC have been reported so far in the world journal. The authors report the 8th case of parathyroid carcinoma in children less than 16 years of age. A 10 year old girl presented with difficulty in walking, dorsiflexion and ulnar deviation of both wrist joints and occasional pain in the central abdomen of about two years duration. Biochemical investigations revealed serum calcium 12.2 mg/dL (normal 9-11 mg/dL), serum alkaline phosphate 4992 U/L (normal 50-136 U/L), PTH (parathyroid hormone) 2217 pg/ml (normal 9-80 pg/ml). Parathyroid scintigraphy localized the lesion in the left parathyroid gland. X-ray showed bilateral coxa vera, genu valgus deformity and multiple stress fractures in both wrist joints. Histopathology confirmed PC with capsular and vascular invasion. PMID:26329966

  5. 10 year course of IQ in first-episode psychosis

    Barder, Helene Eidsmo; Sundet, Kjetil; Rund, Bjørn Rishovd;

    2015-01-01

    are largely uninvestigated, but may identify subgroups with different intellectual trajectories. Eighty-nine first-episode psychosis patients were investigated on IQ at baseline and at 10-years follow-up. Total time in psychosis was defined as two separate variables; Duration of psychosis before start...... of treatment (i.e. duration of untreated psychosis: DUP), and duration of psychosis after start of treatment (DAT). The sample was divided in three equal groups based on DUP and DAT, respectively. To investigate if diagnosis could separate IQ-trajectories beyond that of psychotic duration, two...... diagnostic categories were defined: core versus non-core SSDs. No significant change in IQ was found for the total sample. Intellectual course was not related to DUP or stringency of diagnostic category. However, a subgroup with long DAT demonstrated a significant intellectual decline, mainly associated with...

  6. 1992 Resource Program, 10 Year Plan : Draft II.

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration`s primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  7. 1992 Resource Program, 10 Year Plan : Draft II.

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration's primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  8. Class III treatment using facial mask: Stability after 10 years

    Adilson Luiz Ramos

    2014-10-01

    Full Text Available Early Class III malocclusion treatment may not have long-term stability due to mandibular growth. Although some features of this malocclusion point to a better prognosis, it is practically impossible for the orthodontist to foresee cases that require new intervention. Many patients need retreatment, whether compensatory or orthodontic-surgical. The present study reports the case of a Class III patient treated at the end of the mixed dentition with the use of a face mask followed by conventional fixed appliances. The case remains stable 10 years after treatment completion. It was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as a requirement for the title of certified by the BBO.

  9. The Troubling Trichotomy 10 Years Later: Where Are We Now?

    Barrocas, Albert

    2016-06-01

    A decade ago, "Nutrition Support and The Troubling Trichotomy: A Call To Action" was published in this journal, identifying existing conflicts among technological, ethical, and legal aspects of nutrition support therapy, particularly in terminal or end-of-life situations. Over the past 10 years, the American Society for Parenteral and Enteral Nutrition and others have responded to the action call. A "state of the trichotomy" reveals that while much has been achieved, differences in all 3 aspects will continue to exist due to their dynamic and ever-changing states. The technology arena has made it possible to increase the delivery of nutrition support in alternative settings with the use of telemedicine and social media. Critical/crucial conversations and earlier declarations of individual wishes for care and treatment while having decision-making capacity have been enhanced with the focus on patient-centered and family-centered care. The definition of death as brain death has been challenged in at least one instance. Conflicts between the state's interests and the individual's interests have added to recent legal controversies. Notwithstanding the progress made over the past 10 years, several challenges remain. The future challenges presented by the Troubling Trichotomy can be best confronted if we ACT-Accountability, Communication, and Teamwork. The focus of teamwork should move from multidisciplinary and interdisciplinary teams to transdisciplinary teams, reflecting the shift to function rather than form presented by the new healthcare environment. The transdisciplinary team will be able address the opportunities of the Troubling Trichotomy in the next decade by incorporating the 12 Cs, as detailed in the article. PMID:26941110

  10. Gnathic osteosarcomas: A 10-year multi-center demographic study

    T Azizi

    2009-01-01

    Full Text Available Background: Osteosarcomas (OS of the jaws are uncommon lesions representing 6-8% of skeletal OS. We assessed the characteristics, demographics, prevalence clinical and histopathological findings and distribution of gnathic OS relative to non-gnathic OS in four major treatment centers. Materials and Methods: This study assessed 13 gnathic OS patients of 98 OS patients from four major referral centers during 1996-2007. The age distribution, gender, involved site, clinical findings, signs, symptoms, grade and sub-types were assessed. Hematoxylin-eosin, Picrosirius red, Ponceau trichrome, Masson trichrome and osteoid staining methods were used. Results: Of the 98 OS lesions, 85 (86.8% involved the skeleton, the youngest patient was 6 and the oldest 60 years old; 13 lesions (13.2% involved the jaws (seven mandibular and six maxillary and the youngest and oldest patients were 15 and 50 years-old, respectively. Non-gnathic OS was more prevalent between the ages of 11 and 20 years (avg. 15 years and was common in the distal femur and proximal tibia, presenting most frequently with pain and swelling. OS of the jaws, however, presented more than 10 years later than non-gnathic OS, being more prevalent between the ages of 20 and 30 years (avg. 27 years. OS of the jaws most frequently involved the mandibular body and the posterior maxillary alveolar ridge, presenting frequently with pain, swelling and loosening of teeth. Two patients with gnathic OS died during the 10-year follow-up period (15.3%. Conclusion: Prevalence of OS of the jaws was about twice as high as that reported in other studies and presented later than non-gnathic cases. Pain and swelling were common signs and symptoms in this disease. The mixed sub-type was the most common sub-type of gnathic OS.

  11. Prediction of 10-year Survival in ITI Implant

    AR. Rokn 1, 2,1, 3

    2008-03-01

    Full Text Available Objective: Whilst many questions and doubts still remain, today the use of dental im-plants has gained an increasing popularity amongst patients as well as dentists. The aim of this study is to analyze the survival rate in using such implants over a 10 year period.Materials and Methods: In this study, 3050 ITI implants placed in 1000 patients with the mean age of 49.5 years (54.4% males and 44.6% females during 1050 stages were evalu-ated for the survival rate. The present study is a descriptive, time based analysis of all the files of patients that have been treated using dental implants over a period of 10 years. General information, number of implants in each jaw, type of implant surface, type of edentulous area, time span of Prosthodontic therapy and the endurance of the implants were gathered.Results: Incidence of failure was as low as 2% and the number of implant failures was 23 implants (0.7%. These failures were seen in 13 implants in the upper jaw of 12 patients and 10 implants in the lower jaw of nine patients. In other words, the comprehensive sur-vival rate was seen in 98% of the patients and 99.3% of the implants.Conclusion: The use of dental implants in treatment of missing teeth is favorable regard-less of the subject’s age, sex and type of the edentulous area and a very high survival rate seems feasible.

  12. Availability and cost of wood fuel in 10 years time

    The potential supply of wood fuel in Sweden is very large. Without reductions from ecological, technical and economic reasons the supply is around 125 TWh per year, depending among other things on the future cut of industrial wood. How much of this gross volume of wood fuel will be available on various time horizons, is however not so clear. The aim of this work has been to estimate technically and economically available quantities of wood fuel in a medium time horizon, around 10 years, and considering ecological considerations. This horizon means that today's best available techniques and methods are assumed to be applied widely, which means that today's lowest cost level will dominate in real terms within around 10 years. The applied methodology means that the potential supply of wood fuel of various types is distributed on different cost influencing factors like terrain class, wood fuel concentration and location in relation to nearest road and final user. All types of wood fuels are included, i.e. logging residues, direct fuel cuttings, industrial by-products and recycled wood. As a whole a large part of the total supply is available with today's best technique and with today's average price level of around 115 SEK per MWh (560 SEK per oven dry tonne). Around 60% or 75 TWh can be considered to be economically available in the medium term. In the long range perspective these figures will probably increase considerably, due primarily to the technical development, and provided that sufficient demand is there 44 refs, 8 figs, 12 tabs, 14 appendixes

  13. Subclinical Hypothyroidism Is Associated with Increased Risk for Cancer Mortality in Adult Taiwanese—A 10 Years Population-Based Cohort

    Fen-Yu Tseng; Wen-Yuan Lin; Chia-Ing Li; Tsai-Chung Li; Cheng-Chieh Lin; Kuo-Chin Huang

    2015-01-01

    Background The association between subclinical hypothyroidism (SCH) and cancer mortality is seldom discussed. Methods A total of 115,746 participants without thyroid disease history, aged 20 and above, were recruited from four nationwide health screening centers in Taiwan from 1998 to 1999. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0–19.96 mIU/L with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47–4.9 mIU/L. Cox propor...

  14. Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study.

    Bocca, Beatrice; Forte, Giovanni; Oggiano, Riccardo; Clemente, Simonetta; Asara, Yolande; Peruzzu, Angela; Farace, Cristiano; Pala, Salvatore; Fois, Alessandro Giuseppe; Pirina, Pietro; Madeddu, Roberto

    2015-12-15

    The association between exposure to toxic metals and amyotrophic lateral sclerosis (ALS) was explored in a population-based case-control study in the Sardinia island (Italy), a region characterized by elevated rates of ALS cases. In 34 patients with ALS (mean age, 62 ± 10 years) and 30 controls (mean age, 65 ± 11 years), Al, Cd, Hg, Mn and Pb were determined in blood, hair and urine by sector field inductively coupled mass spectrometry. Results indicated that, in blood, concentrations of Al (p=0.045) and Pb were higher (p=0.026) in ALS patients than in control subjects. In hair, a depletion of Al (p=0.006) and Mn (p=0.032) concentrations in ALS subjects respect to controls was found. In urine, no significant differences between cases and controls were observed. Thus, some metals seemed to be associated with ALS degeneration, but a definitive conclusion is still far considering the multiple risk factors (genetic mutations, environmental toxicants and stressors) involved in the disease. Finally, the interpretation that deregulated metal concentrations can be a consequence of the degenerative process, rather than a cause, is also valid. PMID:26671079

  15. The fate of titanium miniplates and screws used in maxillofacial surgery: a 10 year retrospective study.

    O'Connell, J

    2012-01-31

    The objective of this 10 year, retrospective study is to evaluate the indications for the removal of titanium miniplates following osteosynthesis in maxillofacial trauma and orthognathic surgery. All patients who had miniplates placed in a Regional Oral and Maxillofacial Department between January 1998 and October 2007 were included. The following variables were recorded: patient gender and age, number of plates inserted, indications for plate placement, location of plates, number and location of plates removed, indications for plate removal, time between insertion and removal, medical co-morbidities, and the follow-up period. During the 10 years of the study, 1247 titanium miniplates were placed in 535 patients. A total of 32 (3%) plates were removed from 30 patients. Superficial infection accounted for 41% of all plates removed. All complications were minor and most plates were removed within the first year of insertion. A low removal rate of 3% suggests that the routine removal of asymptomatic titanium miniplates is not indicated.

  16. Vehicle parameter identification using population based algorithms

    GÖKDAĞ, Hakan

    2015-01-01

    This work deals with parameter identification of a vehicle using population based algorithms such as Particle Swarm Optimization (PSO), Artificial Bee Colony Optimization (ABC) and Genetic Algorithm (GA). Full vehicle model with seven degree of freedom (DoF) is employed, and two objective functions based on reference and computed responses are proposed. Solving the optimization problem vehicle mass, moments of inertia and vehicle center of gravity parameters, which are necessary for later app...

  17. A 10-year retrospective study on odontogenic tumors in Iran

    Nasim Taghavi

    2013-01-01

    Full Text Available Objective: The aim of this study was to review cases of odontogenic tumors diagnosed in two pathology centers in Tehran, Iran, during a 10-year period. Study Design: Patients′ records were seen at two teaching pathology Centre′s of Shahid Beheshti University between the months of March 2000 to 2010 with histologic diagnosis of any type of odontogenic tumors. The records were analyzed for frequency, age, sex, site, as well as clinical, radiographic and histopathologic findings. Results: Of 30706 biopsies, 4767 (15.5% cases were diagnosed as oral and maxillofacial lesions. Among these, 720 cases were tumoral with 188 (26.1% cases of odontogenic tumors. Tumors with odontogenic epithelium origin formed 70.2% of total numbers of odontogenic tumors. Mixed odontogenic tumors and tumors of odontogenic ectomesenchyme comprised 12.2% and 17.5% of the cases respectively. Ameloblastoma, with a frequency of 62.2% was the most common tumor in this review which was followed by odontoma and odontogenic myxoma. Conclusion: Although there are few studies on odontogenic tumors in literature, the comparison of our results with existing data shows significant differences in the distribution of tumors and age of patients, which may be due to ethnic features and geographic distribution of patients. Future studies on other ethnic groups are essential for further clarification of the findings in this research.

  18. Competition, resources, and vegetation during 10 years in native grassland.

    Wilson, Scott D

    2007-12-01

    A 10-year experiment tested for variation in competition intensity over time in a natural grassland at the northern edge of the Great Plains. Growing-season precipitation varied fivefold during the study. All ecosystem-level variables varied significantly among years, and most covaried in expected ways. The covers of all common grasses possessing the C3 photosynthetic pathway varied significantly among years; in contrast, all common species with traits associated with drought tolerance (a C4 grass, a lichen, a spikemoss, and a subshrub) did not vary. Annual transplant experiments measured the competitive effects of neighbors on the growth of individuals of the native grass Bouteloua gracilis. A significant interaction between year and competition showed that competition intensity varied among years. The size of this effect, however, was small (eta2 = 0.074) relative to the size of the direct effect of competition (eta2 = 0.20) or the year in which the experiment was conducted (eta2 = 0.51). Further, competition intensity was not significantly related to any variable describing standing crop or resources, or species richness. Species richness was highest in years with high precipitation, standing crop, and individual growth, due to the recruitment of rare species that were absent from dry years. In summary, variation in competition intensity was statistically significant but had small effects relative to the direct effects of climate. PMID:18229830

  19. Pain in the lumbar, thoracic or cervical regions: do age and gender matter? A population-based study of 34,902 Danish twins 20-71 years of age

    Leboeuf-Yde, Charlotte; Nielsen, Jan; Kyvik, Kirsten O; Fejer, René; Hartvigsen, Jan

    2009-01-01

    , aged 20 to 71 years, representative of the general Danish population. Identical questions on pain were asked for the lumbar, thoracic and cervical regions. RESULTS: Low back pain was most common, followed by neck pain with thoracic pain being least common. Pain for at least 30 days in the past year was...

  20. Health-Related Quality of Life in Cervical Cancer Survivors: A Population-Based Survey

    Purpose: In a population-based sample of cervical cancer survivors, health-related quality of life (HRQoL) was assessed 2-10 years postdiagnosis. Methods and Materials: All patients given a diagnosis of cervical cancer in 1995-2003 in the Eindhoven region, The Netherlands, and alive after Jan 2006 were identified through the cancer registry. Generic HRQoL (36-Item Short-Form Health Survey, EQ-5D), cervical cancer-specific HRQoL (European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire cervical cancer module), and anxiety (6-item State Trait Anxiety Inventory) were assessed and compared with a reference population (n = 349). Data for tumor characteristics at diagnosis and disease progression were available. Results: A total of 291 women responded (69%), with a mean age of 53 ± 13 (SD) years (range, 31-88 years). Treatment had consisted of surgery (n = 195) or a combination of therapies (n = 75); one woman had not been treated. Of all women, 85% were clinically disease free, 2% had a recurrence/metastasis, and in 13%, this was unknown. After controlling for background characteristics (age, education, job and marital status, having children, and country of birth), generic HRQoL scale scores were similar to the reference population, except for worse mental health in survivors. The most frequent symptoms were crampy pain in the abdomen or belly (17%), urinary leakage (15%), menopausal symptoms (18%), and problems with sexual activity. Compared with the 6-10-year survivors, more sexual worry and worse body image were reported by the 2-5-year survivors. Compared with surgery only, especially primary radiotherapy was associated with an increased frequency of treatment-related side effects, also after controlling for age and disease stage at diagnosis and follow-up. Conclusions: Most cervical cancer survivors were coping well, although their mental health was worse than in the reference population. Even after 2-10 years, radiotherapy was

  1. Inter-Comparison of 10-year Precipitation Simulated by Several RCMs for Asia

    2006-01-01

    In phase Ⅱ of the Regional Climate Model Inter-comparison Project (RMIP) for Asia, the regional climate has been simulated for July 1988 through December 1998 by five regional climate models and one global variable resolution model. Comparison of the 10-year simulated precipitation with the observations was carried out. The results show that most models have the capacity to reproduce the basic spatial pattern of precipitation for Asia, and the main rainbelt can be reproduced by most models, but there are distinctions in the location and the intensity. Most models overestimate the precipitation over most continental regions. Interannual variability of the precipitation can also be basically simulated, while differences exist between various models and the observations. The biases in the stream field are important reasons behind the simulation errors of the Regional Climate Models (RCMs). The cumulus scheme and land surface process have large influences on the precipitation simulation. Generally, the Grell cumulus scheme produces more precipitation than the Kuo scheme.

  2. Fractures of the mandible and maxilla: A 10-year analysis

    Estie Kruger

    2016-02-01

    Full Text Available Background Previous analysis of jaw fracture hospitalisations in Western Australia (WA indicated disproportionately high rates of hospitalisations for Aboriginal people. This study was to follow-up on the earlier analysis to determine if inequalities in terms of jaw fracture hospitalisation rates between Aboriginal and non-Aboriginal people have changed. Aims This study, done over a 10-year period from 1999/2000 to 2008/2009, aimed to determine rates of hospitalisations for jaw fractures in WA, trends over the 10–year period, and direct costs associated with these hospital admissions. Methods Hospitalisation data were obtained from the Western Australian Hospital Morbidity Data System (HMDS. Episodes were selected on the basis of an ICD10-AM code being S02.4 (Fracture of the malar and maxillary bones and S02.6 (Fracture of the mandible. Self-reported Aboriginality were used to compare Aboriginal to non-Aboriginal populations. Estimated cost of care was determined for each episode using the national standard diagnostic-related group (DRG average price. Results Our findings indicate that inequalities between Aboriginal and non-Aboriginal people in terms of hospital admissions for jaw fractures exist in WA, and continued over a decade- long period. Higher fracture rates occurred amongst males, Aboriginal people, younger adult age-groups, those from low socioeconomic areas, and those from remote and very remote areas. The DRG cost per person for jaw fractures ranged between AUD $842 and $109,002, with a median cost of $4,965. Conclusion Hospital admission rates for the treatment of maxillary and mandibular fractures is very strongly divided along racial and socioeconomic lines in WA.

  3. EVANS SYNDROME IN A 10 YEAR OLD GIRL

    A. Ariputra

    2015-10-01

    Full Text Available Evans syndrome is a coexistence of simultaneous or sequential positive direct Coombs test in conjunctionwith  immune-mediated  thrombocytopenia with no known underlying etiology. The  clinical  course  ischronic and relapsing, and the therapy is generally progressive. Recurrences of thrombocytopenia, anemiaand neutropenia are common, as well as episodes of hemorrhage and serious infections. Noncrossreactingautoantibodies are directed against red cells, platelets, and neutrophils antigens. Evans syndrome isa rare condition, no predilection is known and its exact prevalent is unknown. We report a case of Evanssyndrome in 10 years old girl with severe anemia and thrombocytopenia. Patient came with clinicalsymptoms of severe anemia. The laboratory evaluation showed severe anemia, increased reticulocytecount, anisopoikilocytosis erythrocyte, increased unconjugated bilirubin, positive direct Coombs testand thrombocytopenia. Patient was then managed with high doses of corticosteroids and showed goodresponse from both clinical and laboratory evaluations. [MEDICINA 2015;46:61-66].Sindrom Evans adalah suatu penyakit yang ditandai dengan adanya hasil positif pada direct Coombstest dan trombositopenia yang diperantarai  imun secara simultan atau sekuensial tanpa penyebabyang  jelas. Perjalanan klinis umumnya bersifat kronis, sering mengalami relaps dan memerlukanterapi yang progresif. Kejadian trombositopenia, anemia, neutropenia, perdarahan dan episode infeksiberat berulang umum terjadi. Pada sindrom ini, terjadi reaksi autoantibodi spesifik terhadap antigensel darah merah, trombosit dan juga neutrofil. Sindrom Evans merupakan kasus yang jarang ditemukandan dengan predileksi serta prevalensi yang belum banyak diketahui. Kami melaporkan satu kasusSindrom Evans pada anak perempuan usia 10 tahun.  Pasien dengan gejala klinis anemia berat dan padapemeriksaan laboratorium menunjukkan suatu anemia berat, peningkatan hitung retikulosit, gambaraneritrosit

  4. The GLOBE Program 10 Years On: Challenges and Opportunities

    Blurton, C.

    2004-12-01

    ). This session will examine what was accomplished during GLOBE's first 10 years as a Federal program, what challenges the Program faces, and what plans are afoot for GLOBE's next ten years under UCAR's leadership.

  5. The impact of social factors on human immunodeficiency virus and hepatitis C virus co-infection in a minority region of Si-chuan, the People's Republic of China: a population-based survey and testing study.

    Caiting Dong

    Full Text Available BACKGROUND: While many human immunodeficiency virus (HIV studies have been performed in Liangshan, most were focused only on HIV infection and based on a sampling survey. In order to fully understand HIV and hepatitis C virus (HCV prevalence and related risk factors in this region, this study implemented in 2009, included a survey, physical examination, HIV and HCV test in two towns. METHODS: All residents in two towns of the Butuo county were provided a physical examination and blood tests for HIV and HCV, and then followed by an interview for questionnaire. RESULTS: In total, 10,104 residents (92.4% were enrolled and 9,179 blood samples were collected for HIV and HCV testing, 6,072 were from individuals >14 years old. The rates of HIV, HCV, and HIV/HCV co-infection were 11.4%, 14.0%, and 7.7%, respectively for >14-year-old residents. The 25-34 yr age group had the highest prevalence of HIV, HCV, and HIV/HCV co-infections, reaching 24.4%, 26.2% and 16.0%, respectively. Overall, males had a much higher prevalence of all infections than females (HIV: 16.3% vs. 6.8%, HCV: 24.6% vs. 3.9%, HIV/HCV co-infected: 14.7% vs. 1.1%, respectively; P = 0.000. Approximately half of intravenous drug users tested positive for HIV (48.7% and 68.4% tested positive for HCV. Logistic regression analysis showed that five factors were significantly associated with HIV and HCV infection: gender (odds ratio [OR]  = 5.8, education (OR = 2.29; occupation (student as reference; farmer: OR = 5.02, migrant worker: OR = 6.12; drug abuse (OR = 18.0; and multiple sexual partners (OR = 2.92. Knowledge of HIV was not associated with infection. CONCLUSION: HIV and HCV prevalence in the Liangshan region is very serious and drug use, multiple sexual partners, and low education levels were the three main risk factors. The government should focus on improving education and personal health awareness while enhancing drug control programs.

  6. Gaps in the prevention of perinatal transmission of hepatitis B virus between recommendations and routine practices in a highly endemic region: a provincial population-based study in China

    Hu Yali

    2012-09-01

    Full Text Available Abstract Background Hepatitis B virus (HBV infection is endemic in China; perinatal transmission is the main source of chronic HBV infection. Simultaneous administration of hepatitis B immune globulin (HBIG and hepatitis B vaccine is highly effective to prevent perinatal transmission of HBV; however, the effectiveness also depends on full adherence to the recommended protocols in daily practice. In the present investigation, we aimed to identify gaps in immunoprophylaxis of perinatal transmission of HBV between recommendations and routine practices in Jiangsu Province, China. Methods Totally 626 children from 6 cities and 8 rural areas across Jiangsu Province, China, born from February 2003 to December 2004, were enrolled; 298 were born to mothers with positive hepatitis B surface antigen (HBsAg and 328 were born to HBsAg-negative mothers. Immunoprophylactic measures against hepatitis B were retrospectively reviewed for about half of the children by checking medical records or vaccination cards and the vaccine status was validated for most of children. Results Of 298 children born to HBV carrier mothers, 11 (3.7% were HBsAg positive, while none of 328 children born to non-carrier mothers was HBsAg positive (P  Conclusions There are substantial gaps in the prevention of perinatal HBV infection between the recommendations and routine practices in China, which highlights the importance of full adherence to the recommendations to eliminate perinatal HBV infection in the endemic regions.

  7. Congenital anomalies in children with cerebral palsy: a population-based record linkage study

    Rankin, Judith; Cans, Christine; Garne, Ester;

    2010-01-01

    Our aim was to determine the proportion of children with cerebral palsy (CP) who have a congenital anomaly (CA) in three regions (Isère Region, French Alps; Funen County, Denmark; Northern Region, England) where population-based CP and CA registries exist, and to classify the children according to...

  8. Project Energize: intervention development and 10 years of progress in preventing childhood obesity.

    Rush, Elaine; Cairncross, Carolyn; Williams, Margaret Hinepo; Tseng, Marilyn; Coppinger, Tara; McLennan, Steph; Latimer, Kasha

    2016-01-01

    Prevention of childhood obesity is a global priority. The school setting offers access to large numbers of children and the ability to provide supportive environments for quality physical activity and nutrition. This article describes Project Energize, a through-school physical activity and nutrition programme that celebrated its 10-year anniversary in 2015 so that it might serve as a model for similar practices, initiatives and policies elsewhere. The programme was envisaged and financed by the Waikato District Health Board of New Zealand in 2004 and delivered by Sport Waikato to 124 primary schools as a randomised controlled trial from 2005 to 2006. The programme has since expanded to include all 242 primary schools in the Waikato region and 70 schools in other regions, including 53,000 children. Ongoing evaluation and development of Project Energize has shown it to be sustainable (ongoing for >10 years), both effective (lower obesity, higher physical fitness) and cost effective (one health related cost quality adjusted life year between $18,000 and $30,000) and efficient ($45/child/year) as a childhood 'health' programme. The programme's unique community-based approach is inclusive of all children, serving a population that is 42% Māori, the indigenous people of New Zealand. While the original nine healthy eating and seven quality physical activity goals have not changed, the delivery and assessment processes has been refined and the health service adapted over the 10 years of the programme existence, as well as adapted over time to other settings including early childhood education and schools in Cork in Ireland. Evaluation and research associated with the programme delivery and outcomes are ongoing. The dissemination of findings to politicians and collaboration with other service providers are both regarded as priorities. PMID:26809555

  9. Childhood hospitalisation for otitis media in Western Australia: A 10 - year retrospective analysis

    Nicholas Liu

    2016-05-01

    Full Text Available Background The aim of this study was to assess the prevalence of hospitalisation for otitis media across the different risk indicators for Western Australian children (less than 15 years old over a 10-year period. Method This retrospective population-based study usedthe de-identified detailed data of children under the age of 15 years, hospitalised for otitis media(OM, as determined by principal diagnosis (ICD-10AM and obtained from the Western Australian (WA Hospital Morbidity Dataset for 10 financial years from 1999–2000 to 2008–2009. Various risk indicators, including age, gender, Indigenous status, insurance status, hospital area, hospital type,and length of stay were also analysed. Results Out of 26,294 cases of in-hospital care, Indigenous children comprised 4.7per cent(n=1,226, while the non-Indigenous children comprised 95.3 per cent(n=25,068.The majority of the children, nearly 98.8 per cent were admitted for chronic OM. The children were grouped into three age groups, namely, 0–4 years, 5–9 years, and 10–14 years. Nearly two-thirds of all cases were in the 0–4-year age group.Significantly more non-Indigenous (51per cent than Indigenous children (2-percent had private health insurance. The hospitalisation rates were directly proportional between the number of Indigenous children living in the area and the increasing remoteness of the area along with greater socioeconomic disadvantage. There were 24 per cent more cases from very remote areas compared to highly accessible areas, and there were 60 per cent more cases from the most disadvantaged socioeconomic category, compared with the least disadvantaged category, for Indigenous children. Conclusion These data depict the variations in prevalence of otitis media hospitalisations within the community, as affected by various risk indicators.

  10. Gender-related affecting factors of prediabetes on its 10-year outcome

    Song, Xiaomin; Qiu, Miaoyan; Zhang, Xuan'e; Wang, Haiyan; Tong, Wenxin; Ju, Liping; Gu, Lei; Sun, Siming; Zhang, Hongli; Wang, Weiqing; Tian, Jingyan

    2016-01-01

    Objective To investigate the gender-related affecting factors of prediabetes on its 10-year outcome, in a longitudinal study. Methods and results This longitudinal population-based study was performed in the Ping Liang community, Yangpu district, Shanghai, between November 2002 and October 2014. There were 334 participants with prediabetes enrolled in the final analysis. While a certain proportion of the prediabetic population progress to diabetes, the majority remain at the same level or even revert to normal glucose regulation. No gender difference was observed in the change of glucose regulation. However, results from an adjusted logistic regression analysis in males showed that physical activity was significantly associated with both elevated odds of reverting to normal glucose regulation (active vs inactive, OR 3.00, 95% CI 1.09 to 8.30) and developing diabetes (OR 0.34, 95% CI 0.13 to 0.92). Age, baseline 2 h glucose, triglycerides and smoking status were also risk factors significantly associated with diabetes development; while for females, waist circumference played a key role in the outcome. Every unit elevation of waist circumference was associated with lower odds of reverting to normal glucose regulation (OR, 0.94; 95% CI 0.89 to 0.98) and higher odds of progressing to diabetes (OR, 1.05; 95% CI 1.01 to 1.10). Baseline hypertension and family history of diabetes carried higher risk for developing diabetes as well. Conclusions Physical activity in males and waist circumference in females are important factors predicting both progression to diabetes and regression to normal glucose regulation, indicating that more exercise for males and lower waist circumference for females are beneficial for prediabetes to achieve reversion. PMID:27239315

  11. Evolution of malaria in pregnancy control: Jhpiego's 10-year contribution.

    Roman, Elaine; Ngindu, Augustine; Orji, Bright; Zoungrana, Jérémie; Robbins, Sarah; Brieger, William

    2015-06-01

    Malaria continues to be a life-threatening illness throughout Sub-Saharan Africa, with pregnant women and children being particularly vulnerable and an estimated 10 000 women and 200 000 newborns dying each year as a result of malaria in pregnancy (MIP). Since 2004, WHO has supported a three-pronged MIP approach: (1) intermittent preventive treatment with sulfadoxine-pyrimethamine; (2) use of insecticide-treated bed nets; and (3) effective case management. The present article identifies benchmarks in Jhpiego's 10-plus years of MIP experience at the regional and national levels that have contributed to its global MIP leadership and aligned programs and policies with global approaches toward malaria elimination. As countries continue to develop and expand MIP programming, support will continue to be essential in the following eight MIP program areas: integration, policy, capacity development, community engagement, quality assurance, commodities, monitoring and evaluation, and financing. PMID:26115860

  12. A 10-Year Study of Dermatophytoses in Isfahan, Iran.

    Chadeganipour, Mostafa; Mohammadi, Rasoul; Shadzi, Shahla

    2016-03-01

    Dermatophyte infections are very common worldwide and their epidemiological characteristics vary according to the geographical region and have altered in the last decades. The aim of the present investigation was to determine the diversity of causative agents of dermatophytoses and describe the epidemiological condition of infection in Isfahan, Iran, between 2003 and 2012. Specimens were collected from hair, nail, and skin and were examined by conventional methods such as direct microscopy, culture on sabouraud dextrose agar with chloramphenicol and cycloheximide (Mycosel agar) and sabouraud glucose agar, Trichophyton agars, growth on rice grains, urease test, and hair perforation test. Of 13,469 clinically suspected cases, 11.5% were affected with dermatophytoses. Tinea capitis was the most frequent form of infection (52.7%), followed by tinea corporis (24%), tinea pedis (8.9%). Trichophyton verrucosum was the most prevalent causative agent (40.6%), followed by T. mentagrophytes var. interdigitale (17.6%), Epidermophyton floccosum (13%), T. violaceum (12%), T. rubrum (4.1%). Age range of patients was between 1 and 80 years. Housewives were the most patients in our study. The study emphasizes importance of epidemiological surveys of dermatophyte species for the better management of infection. PMID:25902908

  13. 10 years after Chernobyl, radiation exposure, health effects, safety aspects

    This report sums up the various conferences and symposia which were prompted by the tenth anniversary of the accident in the nuclear power plant of Chernobyl. It was shown that by the accident up to now 31 casualties among the emergency and rescue personal at the site. Offsite no increased number of casualties caused by the accident was observed up to now. In the countries with the highest impact Ukraine, Belarus and Russia, however, an increased number of infant thyroid cancer is observed which is substantially higher than after the nuclear detonations over Japanese cities. Contrary to often published media reports, however, up to now no increases in leukemia or other malignant deceases were observed, neither in the population of the concerned regions nor among the liquidators. The high 137Cs activity concentration in the environment close to the power plant result in exclusion zone even today. The deposition values in Kiev, however, amount to only 30 kBq/m2, in large areas of Ukraine they are below the average values in Austria of 22 kBq/m2. For these areas as well as those outside the former Soviet Union the average doses were less than 1 mSv in the first year, a value which is less than one third of natural annual radiation exposure. Since the reactor accident the activity concentration has significally decreased resulting in an exposure as consequence of the reactor accident of less than 0,8 % of the exposure in the first year. In Austria the exposure in 1996 amounts to less than 0,3 % of natural radiation exposure. (author)

  14. Mathematical development of a 10 years old child phantom for use in internal dosimetry

    The main objectives of this work are: 1) to develop a project of a mathematical phantom representing as far as possible a child of 10 years old and 2)to use this phantom as a base for the specific absorbed fractions (SAF) calculations in the internal organs and skeleton due to the radioisotopes most used in nuclear medicine. This phantom was similar in shape to the Fisher and Snyder one, but several changes were introduced to make the phantom more realistic. Those changes included the addition of a neck region, puting the arms outside the trunk region, changes in the trunk, head and genitalia regions shapes. Several modifications were also done in the skeleton. For instance, the head bones, rib cage, pelvis, vertebral column, scapula, clavicles and the arms and legs bones were made very close to the real anatomic shapes. Some internal organs as the brain, lungs, liver, small and large intestines were also changed as a consenquence of the above modifications. In all those cases, the changes were made not only in the shapes but also in the organs and bones position in such a way to be more representative of the 10 years old anatomic age. Estimates of the SAF obtained by the use of this phantom, resulted, as expected, significantly different from those obtained by the use of a simpler model. In other words, the ratio between the SAF in the organs of the phantom developed in this project and the SAF in the organs of the phantom similar to the adult (obtained by reducing each region of the adult phantom by the use of appropriate factor) vary from 0.37 to 5. Those differences and their meaning are also discussed. (author)

  15. Population-Based Placental Weight Ratio Distributions

    Erin M. Macdonald

    2014-01-01

    Full Text Available The placental weight ratio (PWR is a health indicator that reflects the balance between fetal and placental growth. The PWR is defined as the placental weight divided by the birth weight, and it changes across gestation. Its ranges are not well established. We aimed to establish PWR distributions by gestational age and to investigate whether the PWR distributions vary by fetal growth adequacy, small, average, and large for gestational age (SGA, AGA, and LGA. The data came from a hospital based retrospective cohort, using all births at two London, Ontario hospitals in the past 10 years. All women who delivered a live singleton infant between 22 and 42 weeks of gestation were included (n=41441. Nonparametric quantile regression was used to fit the curves. The results demonstrate decreasing PWR and dispersion, with increasing gestational age. A higher proportion of SGA infants have extreme PWRs than AGA and LGA, especially at lower gestational ages. On average, SGA infants had higher PWRs than AGA and LGA infants. The overall curves offer population standards for use in research studies. The curves stratified by fetal growth adequacy are the first of their kind, and they demonstrate that PWR differs for SGA and LGA infants.

  16. Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study

    Kristinsson, Sigurdur Y.; Pfeiffer, Ruth M.; Björkholm, Magnus; Goldin, Lynn R.; Schulman, Sam; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Wahlin, Anders; Turesson, Ingemar; Landgren, Ola

    2010-01-01

    Patients with multiple myeloma (MM) have an increased risk of venous thrombosis. Interestingly, excess risk of venous thromboembolism has been observed among patients with monoclonal gammopathy of undetermined significance (MGUS). Using population-based data from Sweden, we assessed the risks of venous and arterial thrombosis in 18 627 MM and 5326 MGUS patients diagnosed from 1958 to 2006, compared with 70 991 and 20 161 matched controls, respectively. At 1, 5, and 10 years after MM diagnosis...

  17. Climatological Analysis of the Exclusive Economic Zone of Mexico Based on 10 Years of Satellite Imagery

    Gonzalez Rodriguez, E.; Trasviña-Castro, A.; Aguirre Bahena, F.

    2013-05-01

    To visualize the variability of inorganic carbon in the waters of the Exclusive Economic Zone of Mexico we analysed over 10 years of monthly data 4-km resolution from the MODIS-AQUA satellite. This sensor provides various types of information and for this discussion we selected particulate organic carbon, sea surface temperature and euphotic zone depth. We constructed climatological maps for each month of the year to show the average, maximum, minimum and standard deviation of the three variables. The result of the average particulate organic carbon climatology indicates that the main areas of inorganic carbon production (> 200 mg m3) are the Gulf of California, the west coast of the peninsula of Baja California, the coast of Colima, the Gulf of Tehuantepec and in the Gulf of Mexico the coasts of Yucatan, Tabasco and Tamaulipas. The months presenting higher production occur between December and April. In comparison, lowest climatological mean sea surface temperature (below 14 oC) occurs on the west coast of the Baja California peninsula and it is observed associated with the highest mean particulate organic carbon (>250 mg m-3). Climatological mean sea surface temperature on the coast of Colima, Yucatan, Tabasco and Tamaulipas are about 25 °C and coincide with high values of particulate organic carbon (> 200 mg m-3). The climatological mean euphotic zone depth show lowest values (California, the coast of Colima and the Gulf of Tehuantepec. In the west coast of the peninsula of Baja California greater variability of particulate organic carbon occurs from June to December. In the oceanic domain beyond the continental shelf, particulate organic carbon values are very low (low temperatures and/or low depths of the euphotic zone. The oceanic region shows maximum values for both sea surface temperatures and depth of the euphotic zone as is to be expected in oligotrophic regions of the sea. Anomalies for all three variables will also shown to discuss the interannual

  18. Risk factors of maternal mortality in Sistan region: 10-year report

    Mohammad Sarani

    2014-12-01

    Conclusion: Based on our findings, some factors including multiparity, pregnancy his-tory more than 4 times, short interval between pregnancies lower than 2 years and ma-ternal age more than 35 years were some risk factors for maternal death. Maternal mortality in the postpartum period was more than pre-delivery period. Bleeding was the main cause of maternal mortality. Therefore monitoring of vital signs in the post-partum period and the proper management of bleeding are very important. It is sug-gested that risk assessment should be done for pregnant women in delivery ward for detecting high risk pregnant women. Suitable management for these women especially for patients with postpartum hemorrhage plays an important role to decrease the ma-ternal mortality.

  19. Cow-related trauma: a 10-year review of injuries admitted to a single institution.

    Murphy, Colin G

    2012-02-01

    INTRODUCTION: Bovine-related injuries to farmers are common in rural communities. Many injuries are significant requiring hospital admission and surgery. We reviewed all cattle-related injuries admitted to a regional trauma centre over 10 years and detail the nature of the injuries. METHOD: A retrospective review was undertaken, using hospital inpatient coding system (HIPE) to identify patients admitted following cow-related trauma for the last 10 years. From retrieved charts mechanism of injury was identified, demographics recorded and Injury Severity Score (ISS) and Trauma Injury Severity Score (TRISS) calculated based on the injuries sustained. RESULTS: 47 patients were identified, with a median age of 53 years. 4 injuries occurred in children, and 12 in patients over 65 years old. Three-quarters of those injured were male. Kicking was the most common mechanism of injury (n=21), but charge\\/head-butt injuries and trampling injuries were associated with more serious injury scores. 72% of patients were admitted under Orthopaedics as their primary care team, 25% under General Surgeons, with one patient admitted medically. Mean ISS score was 6.9 (range 1-50). 41 operative interventions were performed on 30 patients during their admission. 6.3% of patients required admission to Intensive Care with a mean length of stay of 12.3 days (range 2-21 days). There was no mortality. CONCLUSION: Cow-related trauma is a common among farming communities and is a potentially serious mechanism of injury that appears to be under-reported in a hospital context. Bovine-related head-butt and trampling injuries should be considered akin to high-velocity trauma.

  20. Multicentric caries prevention program: Mechanical control of dental plaque through periodic professional oral prophylaxis. A 10 years follow up

    LIMA José Eduardo de Oliveira; Cardoso, Cristiane Almeida Baldini; Grazziotin, Gladis Benjamina; Honório, Heitor Marques; Mocelini, Ronize Fátima Pigosso; Santos e Silva, Luely Ribeiro de Carros; Nackachima, Elisa Kumiko; Lima, Daniela Carmesini de Oliveira

    2014-01-01

    AIM: To verify the incidence of dental caries in a multicentric prevention program applied in pediatric dentistry clinics from different regions of Brazil for 10 years, and compare with results obtained by previous studies. MATERIAL AND METHODS: 697 children of both genders, ranging from 30 months to 15 years, were included in a primary preventive strategy program for mechanical control of dental plaque through professional prophylaxis (sodium bicarbonate jet on a monthly schedule). Diagnosis...

  1. Population-based service mammography screening: the Icelandic experience

    Sigurdsson K

    2013-05-01

    Full Text Available Kristjan Sigurdsson,1,3 Elínborg Jóna Ólafsdóttir,21The Icelandic Cancer Detection Clinic, 2The Icelandic Cancer Registry, Icelandic Cancer Society, 3Faculty of Medicine, University of Iceland, Reykjavik, IcelandObjective: This study analyzes the efficacy of the Icelandic population-based service mammography screening.Material and methods: Women aged 40–69 were invited for screening at 2-year intervals starting in November 1987. The study evaluates: (A attendance and other screened performance parameters during 1998–2010; (B trends in age-standardized and age-specific incidence rates during 1969–2010 and mortality rates during 1969–2010; and (C distribution of risk factors and disease specific death rates according to mode of detection.Results: (A In the age group of 40–69, the average 2-year attendance was 62%, recall rate was 4.1%, needle biopsy rate was 1.3%, surgery rate was 0.6%, invasive cancer rate was 0.4%, and ductal carcinoma in situ (DCIS rate was 0.06%. (B The linear incidence trend after the start of screening decreased significantly in the age group 40–49, increased significantly in the age group 50–69, but decreased non-significantly in the age group 70–79. The decreased age-specific incidence in the 70–79 age group was, however, greater than the increased age-specific incidence at the ages 50–69. The mortality rate decreased 41% for all age groups and the linear mortality trend decreased significantly at ages 40–49, 50–69, and 70–79. In the age group 40–74 years, the age-specific mortality decreased by 6.9 cases per 2000 during a 10-year period. (C Screen-detected women had significantly smaller tumors, more favorable tumor grade, fewer axillary metastases and, after correction for other risk factors, the likelihood of dying from cancer decreased 54% (hazard ratio: 0.46; 95% confidence interval: 0.31–0.69 for these patients compared to cases of nonparticipators.Conclusion: The study results

  2. Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern

    Krumpaszky, H. G.; Lüdtke, R; Mickler, A.; Klauss, V.; Selbmann, H. K.

    1999-01-01

    Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap. Material and Methods: Population-based investigation on the incidence of legal blindness (visual acuity

  3. Prevalence and geographical distribution of Escherichia coli O157 in India: a 10-year survey.

    Sehgal, Rakesh; Kumar, Yashwant; Kumar, Sunil

    2008-04-01

    Escherichia coli colonizes the human gastrointestinal tract and produces a variety of diseases. Escherichia coli O157 is one of the most important pathogenic strains reported from food-borne illnesses leading to enterohemorrhagic colitis. The National Salmonella and Escherichia Centre is a national reference centre for Salmonella and Escherichia for India; it receives samples from research laboratories, hospitals and institutions for serological identification. The present study is an epidemiological survey of E. coli O157 in different regions of India. The data are based on samples received from humans, food items, animals and the environment. A total of 17 093 isolates cultured from samples were received during the 10-year period of which 5678 were from human sources. Thirty (0.5%) human samples were positive for E. coli O157. A significantly high percentage of E. coli O157 were isolated from meat (0.9%, 13/1376), milk and milk products (1.8%, 10/553), seafood (8.4%, 16/190) and water (1.6%, 8/486). The isolates were found to be distributed among domestic and wild animals, and the maximum number of isolates of E. coli O157 was detected in samples received from coastal belt areas. Escherichia coli O157 is widely distributed among humans and animals, food and environment in different geographical regions of India. PMID:18321544

  4. Changes in the Capacity of Visual Working Memory in 5- to 10-Year-Olds

    Riggs, Kevin J.; McTaggart, James; Simpson, Andrew; Freeman, Richard P. J.

    2006-01-01

    Using the Luck and Vogel change detection paradigm, we sought to investigate the capacity of visual working memory in 5-, 7-, and 10-year-olds. We found that performance on the task improved significantly with age and also obtained evidence that the capacity of visual working memory approximately doubles between 5 and 10 years of age, where it…

  5. Self-Esteem during University Studies Predicts Career Characteristics 10 Years Later

    Salmela-Aro, Katariina; Nurmi, Jari-Erik

    2007-01-01

    To examine how self-esteem measured during university studies would impact on the characteristics of the work career 10 years later, 297 university students completed the Rosenberg's self-esteem inventory four times while at university and various career-related questionnaires 10 years later. Latent Growth Curve Modeling showed that a high overall…

  6. Energy-water analysis of the 10-year WECC transmission planning study cases.

    Tidwell, Vincent Carroll; Passell, Howard David; Castillo, Cesar; Moreland, Barbara

    2011-11-01

    modules for calculating water withdrawal and consumption for current and planned electric power generation; projected water demand from competing use sectors; and, surface and groundwater availability. WECC's long range planning is organized according to two target planning horizons, a 10-year and a 20-year. This study supports WECC in the 10-year planning endeavor. In this case the water implications associated with four of WECC's alternative future study cases (described below) are calculated and reported. In future phases of planning we will work with WECC to craft study cases that aim to reduce the thermoelectric footprint of the interconnection and/or limit production in the most water stressed regions of the West.

  7. A population-based Habitable Zone perspective

    Zsom, Andras

    2015-01-01

    What can we tell about exoplanet habitability if currently only the stellar properties, planet radius, and the incoming stellar flux are known? A planet is in the Habitable Zone (HZ) if it harbors liquid water on its surface. The HZ is traditionally conceived as a sharp region around stars because it is calculated for one planet with specific properties. Such an approach is limiting because the planets' atmospheric and geophysical properties, which influence the presence of liquid water on the surface, are currently unknown but expected to be diverse. A statistical HZ description is outlined which does not favor one planet type. Instead the stellar and planet properties are treated as random variables and a continuous range of planet scenarios are considered. Various probability density functions are assigned to each random variable, and a combination of Monte Carlo sampling and climate modeling is used to generate synthetic exoplanet populations with known surface climates. Then, the properties of the liquid...

  8. A population-based study of glioblastoma multiforme

    Purpose: To describe (1) the use of surgery and radiotherapy (RT) in the treatment of patients with glioblastoma (GBM) in Ontario, (2) survival, and (3) proportion of survival time spent in the hospital after diagnosis. Methods and Materials: We performed a population-based cohort study of all Ontario Cancer Registry (OCR) cases of GBM diagnosed between 1982 and 1994. We linked OCR records, hospital files containing surgical procedure codes from the Canadian Institute for Health Information, and province-wide RT records. We studied the odds of treatment using multivariate logistic regression. We expressed the time spent in the hospital as the mean number of days per case, and as a proportion of the interval between diagnosis and death, or 24 months following diagnosis, whichever came first. We used the life-table method and Cox proportional hazards regression to describe survival. Results: The proportion of patients with GBM undergoing any surgery directed at the tumor varied with age (p<0.0001) and region of residence (p<0.0001). The proportion undergoing RT varied with age (p<0.0001), region of residence (p<0.0001), and year of diagnosis (p=0.01). RT dose ≥53.5 Gy varied with age (p<0.0001), region of residence (p<0.0001), and year of diagnosis (p=0.0002). Median survival was 11 months among patients receiving RT and 3 months among those not receiving RT. The percentage of survival time spent in the hospital was similar among those who received from 49.5 to <53.5 Gy, compared to ≥53.5 Gy. Overall survival and the adjusted relative risk of death varied with age and region of residence. Conclusion: We observed practice variation in the treatment of patients with GBM according to age, region of residence, and year of diagnosis. Survival did not increase during the study period. The variation in RT dose between those receiving from 49.5 to <53.5 Gy compared to ≥53.5 Gy was not paralleled by variation in survival between regions where one or the other of the

  9. Operations, Maintenance, and Replacement 10-Year Plan 1990-1999 : Environmental Strategy. Final Report.

    United States. Bonneville Power Administration.

    1990-09-01

    In operating and maintaining its regional power transmission system, Bonneville Power Administration (BPA) must address environmental concerns. Pollution sources and pathways for pollution migration, including potential contamination from hazardous or toxic materials, are present. BPA must develop and follow precautionary measures, respond to emergencies, minimize wastes, redress past problems, alert and train employees to problems and safety needs, constantly evaluate this effort and update the program for improvements and changes in regulations and technology. Part of BPA's mission is to conduct its operation, maintenance, and replacement programs in an environmentally sound manner. BPA recognizes its responsibility to be good stewards of the environment. BPA will meet its environmental obligations as set forth in environmental laws and regulations. BPA intends to make consistent and measurable progress toward meeting these responsibilities. The target for the 10-Year Plan is to achieve environmental compliance and meet the following goals: (1) protect human health and the environment; (2) avoid or limit liability (3) set up an effective internal management structure to maintain compliance; and (4) achieve cost-effective compliance. 6 figs.

  10. Assessment of 10-Year Global Record of Aerosol Products from the OMI Near-UV Algorithm

    Ahn, C.; Torres, O.; Jethva, H. T.

    2014-12-01

    Global observations of aerosol properties from space are critical for understanding climate change and air quality applications. The Ozone Monitoring Instrument (OMI) onboard the EOS-Aura satellite provides information on aerosol optical properties by making use of the large sensitivity to aerosol absorption and dark surface albedo in the UV spectral region. These unique features enable us to retrieve both aerosol extinction optical depth (AOD) and single scattering albedo (SSA) successfully from radiance measurements at 354 and 388 nm by the OMI near UV aerosol algorithm (OMAERUV). Recent improvements to algorithms in conjunction with the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) and Atmospheric Infrared Sounder (AIRS) carbon monoxide data also reduce uncertainties due to aerosol layer heights and types significantly in retrieved products. We present validation results of OMI AOD against space and time collocated Aerosol Robotic Network (AERONET) measured AOD values over multiple stations representing major aerosol episodes and regimes. We also compare the OMI SSA against the inversion made by AERONET as well as an independent network of ground-based radiometer called SKYNET in Japan, China, South-East Asia, India, and Europe. The outcome of the evaluation analysis indicates that in spite of the "row anomaly" problem, affecting the sensor since mid-2007, the long-term aerosol record shows remarkable sensor stability. The OMAERUV 10-year global aerosol record is publicly available at the NASA data service center web site (http://disc.sci.gsfc.nasa.gov/Aura/data-holdings/OMI/omaeruv_v003.shtml).

  11. Risk Assessment Tool for Estimating Your 10-Year Risk of Having a Heart Attack

    ... Education Programs Continuing Education Opportunities Health Observances Risk Assessment Tool for Estimating Your 10-year Risk of Having a Heart Attack The risk assessment tool below uses information from the Framingham Heart ...

  12. Natrelle Round Silicone Breast Implants: Core Study Results at 10 Years

    Spear, Scott L.; Murphy, Diane K.

    2014-01-01

    Background: Allergan’s Natrelle round silicone-filled breast implants were approved by the U.S. Food and Drug Administration in 2006 based on interim results from the Core Study; final 10-year study results are now available. Methods: Seven hundred fifteen subjects were implanted with smooth and Biocell textured Natrelle round silicone implants and attended clinic visits at 0 to 4 weeks, 6 months, 1 year, and annually through 10 years. Approximately one-third of subjects underwent magnetic re...

  13. Oral Hygiene Facilitators and Barriers in Greek 10 Years Old Schoolchildren

    Angelopoulou, Matina; Kavvadia, Katerina; Oulis, Constantine; Reppa, Christina

    2015-01-01

    ABSTRACT Aim: The aim of this study was to determine the oral hygiene facilitators and barriers for 10 years old Greek children, via a questionnaire and clinical examination. Materials and methods: This was a cross-sectional study of 266, 10 years old, children recruited from schools in 3 locations in Greece. Data were collected via questionnaires and clinical examination. Questionnaires referred to Children’s oral hygiene knowledge, behavior and attitude as well as parents’ oral hygiene beha...

  14. Relationship Between Somatotype and PHV in Iranian 7-10 Years Old Boys

    Amir Hossein Barati; Ali Pashabadi; Mohamadreza Mahmoudkhani; Majid Nayeri

    2013-01-01

    Introduction: An important variable in investigation of agility during puberty is the age of reaching peak high velocity, which like other agility indicators is under the effect of different factors such as physical condition and type. The purpose of present research was to examine relationship between somatotype and peak high velocity (PHV) among Iranian 7-10 years old boys. Methods: Participants were 313 7-10 year-old members of Basij talent identification centers in all Iran's provinces...

  15. Blindness and eye diseases in Tibet: findings from a randomised, population based survey

    Dunzhu, S; Wang, F S; Courtright, P; Liu, L; Tenzing, C; Noertjojo, K; WILKIE, A; Santangelo, M.; Bassett, K L

    2003-01-01

    Background: Public health officials of the Tibet Autonomous Region (TAR) of China requested a survey of blindness, eye diseases, and eye care service utilisation to assist the development of a 10 year blindness prevention and treatment plan. The objective of the survey was to determine the prevalence of blindness and visual impairment, as well as cataract surgical coverage and surgical outcome in the TAR.

  16. Cataract surgery in a population-based cohort of patients with type 1 diabetes

    Grauslund, Jakob; Green, Anders; Sjølie, Anne K

    2011-01-01

    ABSTRACT. Purpose: To estimate the long-term cumulative incidence of cataract surgery and associated risk factors in a 25-year follow-up of a population-based cohort of patients with type 1 diabetes. Methods: Based on insulin prescriptions, a population-based cohort of 727 patients with type 1...... surgery was evaluated during follow-up. Results: The 25-year crude cumulative incidence of cataract surgery was 20.8% (117 of 562 patients at risk), corresponding to a mortality-adjusted incidence of 29.4% [95% confidence interval (CI) 25.6-33.1%]. Median age and duration of diabetes at the time of...... surgery were 59.3 and 42 years, respectively. Cataract surgery in the cohort took place approximately 20 years earlier compared to non-diabetic persons. In a multivariate regression analysis, baseline age [hazard ratio (HR) 1.89 per 10 years, 95% CI 1.46-2.27] and maculopathy (HR 1.89, 95% CI 1...

  17. HEMIPELVECTOMY: ERASTO GAERTNER HOSPITAL'S EXPERIENCES WITH 32 CASES IN 10 YEARS

    Freitas, Rosyane Rena de; Crivellaro, André Luiz Soares; Mello, Glauco José Pauka; Neto, Múrio Armani; Filho, Geraldo de Freitas; Silva, Letícia Viani da

    2015-01-01

    Objective: To show the experience of the Erasto Gaertner Hospital with hemipelvectomy surgery over a 10-year period. Methods: This was a retrospective study on 32 patients who underwent hemipelvectomy at Erasto Gaertner Hospital between 1998 and 2008, assessing clinical and surgical characteristics. Results: Among the 32 patients, 15 were female and 17 were male. The mean age was 37.94 years. Eight cases showed involvement of the neurovascular bundle: three were located in the iliac and extended to the thigh, two were in the acetabulum and extended to the thigh and three were in the acetabulum and pubis. Twenty-three cases presented a neurovascular bundle free from neoplasia: 11 were restricted to the iliac, six were in the acetabular region, two were in the pubic ramus and four extended to the whole hemipelvis bone. One case involved the iliac-femoral vessels: one in the pubic ramus. Seven cases of chondrosarcoma and four cases of Ewing's sarcoma represented the majority. Eight cases underwent external hemipelvectomy and 24 underwent internal hemipelvectomy (11 were type I; four were type II; two were type II + III; three were type III and four were type IV). Of these 24 cases, 13 did not have any reconstruction, 10 had a fibular graft and one had an iliacfemoral vein and artery prosthesis. Twenty-six surgeries were curative and six were palliative. There were 14 deaths. Survival of two and five years was seen in 11 and 10 cases, respectively. For six cases, less than two years had passed since the operation. Three cases were lost during follow-up. Conclusion: This study shows the experiences of an oncology reference service specializing in highly complex surgical treatment. PMID:27022573

  18. Haiti's progress in achieving its 10-year plan to eliminate cholera: hidden sickness cannot be cured.

    Koski-Karell, Victoria; Farmer, Paul E; Isaac, Benito; Campa, Elizabeth M; Viaud, Loune; Namphy, Paul C; Ternier, Ralph; Ivers, Louise C

    2016-01-01

    Since the beginning of the cholera epidemic in Haiti 5 years ago, the prevalence of this deadly water-borne disease has fallen far below the initial rates registered during its explosive outset. However, cholera continues to cause extensive suffering and needless deaths across the country, particularly among the poor. The urgent need to eliminate transmission of cholera persists: compared to the same period in 2014, the first 4 months of 2015 saw three times the number of cholera cases. Drawing upon epidemiology, clinical work (and clinical knowledge), policy, ecology, and political economy, and informed by ethnographic data collected in a rural area of Haiti called Bocozel, this paper evaluates the progress of the nation's 10-year Plan for the Elimination of Cholera. Bocozel is a rice-producing region where most people live in extreme poverty. The irrigation network is decrepit, the land is prone to environmental shocks, fertilizer is not affordable, and the government's capacity to assist farmers is undermined by resource constraints. When peasants do have rice to sell, the price of domestically grown rice is twice that of US-imported rice. Canal water is not only used to irrigate thousands of acres of rice paddies and sustain livestock, but also to bathe, wash, and play, while water from wells, hand pumps, and the river is used for drinking, cooking, and bathing. Only one out of the three government-sponsored water treatment stations in the research area is still functional and utilized by those who can afford it. Latrines are scarce and often shared by up to 30 people; open defecation remains common. Structural vulnerabilities cut across all sectors - not just water, sanitation, health care, and education, but agriculture, environment, (global and local) commerce, transportation, and governance as well. These are among the hidden sicknesses that impede Haiti and its partners' capacity to eliminate cholera. PMID:27307774

  19. Incidence of Alzheimer′s disease in India: A 10 years follow-up study

    P S Mathuranath

    2012-01-01

    Full Text Available Objective: To determine overall and age-specific incidence rates of Alzheimer′s disease (AD in a southern Indian province, Kerala. Materials and Methods: A 10-year (2001-2011 prospective epidemiologic study of community residing subjects aged ≥55 years at enrollment. The catchment area included four urban and semi-urban regions of Trivandrum city in Kerala, India, was selected to provide a range of demographic and socioeconomic representation. Cognitive and functional ability screening were done at baseline and 24-month follow-up assessments. Consensus diagnostic procedures were done using the Diagnostic and Statistical Manual of Mental Disorders, 4 th edition (DSM-IV, and the National Institute of Neurological and Communicative Disorders and Stroke - Alzheimer′s Disease and Related Disorders Association (NINDS-ADRDA criteria for the diagnosis of dementia and AD. Results: Among the 1066 eligible participants who were cognitively normal at baseline, 104 developed dementia (98 with AD over a follow-up period of 8.1 years. The incidence rates per 1000 person-years for AD was 11.67 (95% CI: 10.9-12.4 for those aged ≥55 years and higher for those aged ≥65 years (15.54, 95% CI: 14.6-16.5. In those aged ≥65 years, the world age standardized incidence rate was 21.61 per 100,000, and standardized against the age distribution for the year 2000 U.S. Census, the age-adjusted incidence rate was 9.19 (95% CI: 9.03-9.35 per 1000 person-years. Incidence rate of AD increased significantly and proportionately with increasing age. Conclusion: These are the first AD incidence rates to be reported from southern India. The incidence rates appear to be much higher than that reported from rural north India, comparable with that reported from China, and marginally lower than that reported from the western world.

  20. The genetics of Alzheimer's disease in Brazil: 10 years of analysis in a unique population.

    Oliveira, J R M; Nishimura, A L; Lemos, R R; Zatz, M

    2009-01-01

    Alzheimer's Disease (AD) is the most common type of dementia among the elderly, with devastating consequences for the patient, their relatives, and caregivers. More than 300 genetic polymorphisms have been involved with AD, demonstrating that this condition is polygenic and with a complex pattern of inheritance. This paper aims to report and compare the results of AD genetics studies in case-control and familial analysis performed in Brazil since our first publication, 10 years ago. They include the following genes/markers: Apolipoprotein E (APOE), 5-hidroxytryptamine transporter length polymorphic region (5-HTTLPR), brain-derived neurotrophin factor (BDNF), monoamine oxidase A (MAO-A), and two simple-sequence tandem repeat polymorphisms (DXS1047 and D10S1423). Previously unpublished data of the interleukin-1alpha (IL-1alpha) and interleukin-1 beta (IL-1beta) genes are reported here briefly. Results from others Brazilian studies with AD patients are also reported at this short review. Four local families studied with various markers at the chromosome 21, 19, 14, and 1 are briefly reported for the first time. The importance of studying DNA samples from Brazil is highlighted because of the uniqueness of its population, which presents both intense ethnical miscegenation, mainly at the east coast, but also clusters with high inbreeding rates in rural areas at the countryside. We discuss the current stage of extending these studies using high-throughput methods of large-scale genotyping, such as single nucleotide polymorphism microarrays, associated with bioinformatics tools that allow the analysis of such extensive number of genetics variables, with different levels of penetrance. There is still a long way between the huge amount of data gathered so far and the actual application toward the full understanding of AD, but the final goal is to develop precise tools for diagnosis and prognosis, creating new strategies for better treatments based on genetic profile. PMID

  1. Aerosol climatology over South Africa based on 10 years of Multiangle Imaging Spectroradiometer (MISR) data

    Tesfaye, M.; Sivakumar, V.; Botai, J.; Mengistu Tsidu, G.

    2011-10-01

    In this paper, we present a detailed study of the spatial and seasonal aerosol climatology over South Africa (SA), based on Multiangle Imaging Spectroradiometer (MISR) data. We have used 10 years (2000-2009) of MISR monthly mean aerosol extinction (τext), absorption (τa) optical depths at 558 nm, Angstrom exponents in visible (VIS; 446-672 nm) and near-infrared (NIR; 672-866 nm) spectral bands, and the extracted spectral curvature. The study has shown that, in terms of aerosol load level spatial variation, SA can be classified into three parts: the upper, central, and lower, which illustrate high, medium, and low aerosol loadings, respectively. The results for the three parts of SA are presented in detail. The prevailing sources of aerosols are different in each part of SA. The lower part is dominated by the air mass transport from the surrounding marine environment and other SA or neighboring regions, while the central and upper parts are loaded through wind-ablated mineral dust and local anthropogenic activities. During the biomass burning seasons (July-September), the central part of SA is more affected than the rest of SA by the biomass-burning aerosols (based on τa, ˜20% higher than the rest of SA). In alignment with the observed higher values of τext, aerosol size distributions were found to be highly variable in the upper part of SA, which is due to the high population and the industrial/mining/agricultural activities in this area.

  2. Surprises in the Saturn System: 10 Years of Cassini Discoveries and More Excitement to Come

    Spilker, L. J.; Altobelli, N.; Edgington, S. G.

    2014-12-01

    Cassini's findings have revolutionized our understanding of Saturn, its complex rings, the amazing assortment of moons and the planet's dynamic magnetic environment. The robotic spacecraft arrived in 2004 after a 7-year flight from Earth, dropped a parachuted probe named Huygens to study the atmosphere and surface of Saturn's big moon Titan, and commenced making astonishing discoveries that continue today. Icy jets shoot from the tiny moon Enceladus; Titan's hydrocarbon lakes and seas are dominated by liquid ethane and methane, and complex pre-biotic chemicals form in the atmosphere and rain to the surface; 3-dimensional structures rise above Saturn's rings, and a giant Saturn storm circled the entire planet. Cassini's findings at Saturn have also fundamentally altered many of our concepts of how planets form around stars. The Solstice Mission continues to provide fundamental new science as Cassini observes seasonal and temporal changes, and addresses new questions that have arisen during the mission thus far. The mission's grand finale occurs in 2017, with 22 inclined orbits between the innermost D ring and the upper portions of Saturn's atmosphere, enabling unique gravity and magnetic field measurements of the planet, unprecedented determination of the ring mass, some of the highest resolution measurements of the rings and Saturn, and in situ observations in a completely new region around the planet. Highlights from 10 years of Cassini's ambitious inquiry at Saturn will be presented along with the remarkable science that will be collected in the next three years. Cassini-Huygens is a cooperative undertaking by NASA, the European Space Agency (ESA), and the Italian space agency (Agenzia Spaziale Italiana, ASI). This work was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA. Copyright 2014 California Institute of Technology. Government sponsorship is acknowledged.

  3. Evaluation of two population-based input functions for quantitative neurological FDG PET studies

    The conventional measurement of the regional cerebral metabolic rate of glucose (rCMRGlc) with fluorodexoyglucose (FDG) and positron emission tomography (PET) requires arterial or arterialised-venous (a-v) blood sampling at frequent intervals to obtain the plasma input function (IF). We evaluated the accuracy of rCMRGlc measurements using population-based IFs that were calibrated with two a-v blood samples. Population-based IFs were derived from: (1) the average of a-v IFs from 26 patients (Standard IF) and (2) a published model of FDG plasma concentration (Feng IF). Values for rCMRGlc calculated from the population-based IFs were compared with values obtained with IFs derived from frequent a-v blood sampling in 20 non-diabetic and six diabetic patients. Values for rCMRGlc calculated with the different IFs were highly correlated for both patient groups (r≥0.992) and root mean square residuals about the regression line were less than 0.24 mg/min/100 g. The Feng IF tended to underestimate high rCMRGlc. Both population-based IFs simplify the measurement of rCMRGlc with minimal loss in accuracy and require only two a-v blood samples for calibration. The reduced blood sampling requirements markedly reduce radiation exposure to the blood sampler. (orig.)

  4. Managing incidental findings in population based biobank research

    Berge Solberg

    2012-04-01

    Full Text Available With the introduction of whole genome sequencing in medical research, the debate on how to handle incidental findings is becoming omnipresent. Much of the literature on the topic so far, seems to defend the researcher’s duty to inform, the participant’s right to know combined with a thorough informed consent in order to protect and secure high ethical standards in research. In this paper, we argue that this ethical response to incidental findings and whole genome sequencing is appropriate in a clinical context, in what we call therapeutic research. However, we further argue, that it is rather inappropriate in basic research, like the research going on in public health oriented population based biobanks. Our argument is based on two premises: First, in population based biobank research the duties and rights involved are radically different from a clinical based setting. Second, to introduce the ethical framework from the clinical setting into population based basic research, is not only wrong, but it may lead to unethical consequences. A Norwegian population based biobank and the research-ethical debate in Norway on the regulation of whole genome sequencing is used as an illustrative case to demonstrate the pitfalls when approaching the debate on incidental findings in population based biobank research.

  5. Physical activity in leisure-time is not associated with 10-year changes in waist circumference

    Berentzen, T.; Petersen, L.; Schnohr, P.; Sørensen, Thorkild I.A.

    2008-01-01

    To examine whether physical activity (PA) is associated with changes in waist circumference (WC), and changes in WC given changes in body mass index (BMI). Longitudinal population-based study including 2026 men and 2782 women aged 21-81 years. Subjects were examined in 1991-1993 (baseline) and 2001...

  6. Overeating and Binge Eating in Emerging Adulthood: 10-Year Stability and Risk Factors

    Goldschmidt, Andrea B.; Wall, Melanie M.; Zhang, Jun; Loth, Katie A.; Neumark-Sztainer, Dianne

    2016-01-01

    Overeating (eating an unusually large amount of food) and binge eating (overeating with loss of control [LOC]) predict adverse health consequences in adolescence. We aimed to characterize the stability of and risk factors for these distinct but interrelated constructs during critical developmental transitions. We used a population-based sample (n…

  7. 1989-1998: 10 years of environmental radiological monitoring in provinces of Ciego de Avila, Camaguey and Las Tunas, Cuba

    A review of the results, obtained by the Radiological Environmental Monitoring Department of the Center for Attention of Nuclear Activity Camaguey in 10 years of radiological environmental monitoring in the central-eastern region of Cuba, is made. The Network included 11 points of monitoring in three provinces. Radiological parameters, such as: measurements of gross-beta activities in Fallout; gamma dose rate absorbed by air using two methods: real time measurements and thermoluminescent dosimeters, gross-beta activities in atmospheric aerosols, and Polonium-210 activity in foods, are calculated. The values of the above mentioned radiological parameters are given for each monitoring point, and a comparison with other regions of our country and of the world, is made. The results show that this region has been exposed only to global radioactive contaminants and background reference levels are indicated

  8. A population based case-control study of agricultural injuries in children.

    Stueland, D. T.; Lee, B.C.; Nordstrom, D L; Layde, P M; Wittman, L. M.

    1996-01-01

    OBJECTIVES: To identify preventable risk factors related to agricultural injuries occurring to children on family farms. SETTING: A geographically defined central region of Wisconsin, USA with nearly 1800 family dairy farms. METHODS: A two year, population based incidence study of occupational injuries among farm residents was conducted. For cases, trained staff abstracted information on the nature, severity, and treatment of the injury from the patient's medical record. Staff also administer...

  9. Risk factors for homicide victimization in post-genocide Rwanda : a population - based case- control study

    Rubanzana, Wilson; Ntaganira, Joseph; Freeman, Michael D; Hedt-Gauthier, Bethany L.

    2015-01-01

    Background: Homicide is one of the leading causes of mortality in the World. Homicide risk factors vary significantly between countries and regions. In Rwanda, data on homicide victimization is unreliable because no standardized surveillance system exists. This study was undertaken to identify the risk factors for homicide victimization in Rwanda with particular attention on the latent effects of the 1994 genocide. Methods: A population-based matched case-control study was conducted, with sub...

  10. Maternal sepsis: a Scottish population-based case–control study

    Acosta, CD; Bhattacharya, S; Tuffnell, D; Kurinczuk, JJ; Knight, M.

    2012-01-01

    Objective To describe the risk of maternal sepsis associated with obesity and other understudied risk factors such as operative vaginal delivery. Design Population-based, case–control study. Setting North NHS region of Scotland. Population All cases of pregnant, intrapartum and postpartum women with International Classification of Disease-9 codes for sepsis or severe sepsis recorded in the Aberdeen Maternal and Neonatal Databank (AMND) from 1986 to 2009. Four controls per case selected from t...

  11. Risk factors for homicide victimization in post-genocide Rwanda: a population -based case- control study

    Rubanzana, Wilson; Ntaganira, Joseph; Freeman, Michael D.; Hedt-Gauthier, Bethany L

    2015-01-01

    Background: Homicide is one of the leading causes of mortality in the World. Homicide risk factors vary significantly between countries and regions. In Rwanda, data on homicide victimization is unreliable because no standardized surveillance system exists. This study was undertaken to identify the risk factors for homicide victimization in Rwanda with particular attention on the latent effects of the 1994 genocide. Methods: A population-based matched case–control study was conducted, with sub...

  12. AMIE SMART-1: review of results and legacy 10 years after launch

    Josset, Jean-Luc; Souchon, Audrey; Josset, Marie; Foing, Bernard

    2014-05-01

    The Advanced Moon micro-Imager Experiment (AMIE) camera was launched in September 2003 onboard the ESA SMART-1 spacecraft. We review the technical characteristics, scientific objectives and results of the instrument, 10 years after its launch. The AMIE camera is an ultra-compact imaging system that includes a tele-objective with a 5.3° x 5.3° field of view and an imaging sensor of 1024 x 1024 pixels. It is dedicated to spectral imaging with three spectral filters (750, 915 and 960 nm filters), photometric measurements (filter free CCD area), and Laser-link experiment (laser filter at 847 nm). The AMIE camera was designed to acquire high-resolution images of the lunar surface, in white light and for specific spectral bands, under a number of different viewing conditions and geometries. Specifically, its main scientific objectives included: (i) imaging of high latitude regions in the southern hemisphere, in particular the South Pole Aitken basin and the permanently shadowed regions close to the South Pole; (ii) determination of the photometric properties of the lunar surface from observations at different phase angles (physical properties of the regolith); (iii) multi-band imaging for constraining the chemical and mineral composition of the surface; (iv) detection and characterisation of lunar non-mare volcanic units; (v) study of lithological variations from impact craters and implications for crustal heterogeneity. The study of AMIE images enhanced the knowledge of the lunar surface, in particular regarding photometric modelling and surface physical properties of localized lunar areas and geological units. References: http://scholar.google.nl/scholar?q=smart-1+amie We acknowledge ESA, member states, industry and institutes for their contribution, and the members of the AMIE Team: J.-L. Josset, P. Plancke, Y. Langevin, P. Cerroni, M. C. De Sanctis, P. Pinet, S. Chevrel, S. Beauvivre, B.A. Hofmann, M. Josset, D. Koschny, M. Almeida, K. Muinonen, J. Piironen, M. A

  13. Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study.

    Carma Karam

    Full Text Available Surveys measuring effectiveness of public awareness campaigns in reducing cardiovascular disease (CVD incidence have yielded equivocal findings. The aim of this study was to describe cardiovascular risk factors (CVRFs changes over the years in an untreated population-based study.Between 2007 and 2012, we conducted a screening campaign for CVRFs in men aged 40 to 65 yrs and women aged 50 to 70 yrs in the western suburbs of Paris. Data were complete for 20,324 participants of which 14,709 were untreated.The prevalence trend over six years was statistically significant for hypertension in men from 25.9% in 2007 to 21.1% in 2012 (p=0.002 and from 23% in 2007 to 12.7% in 2012 in women (p<0.0001. The prevalence trend of tobacco smoking decreased from 38.6% to 27.7% in men (p=0.0001 and from 22.6% to 16.8% in women (p=0.113. The Framingham 10-year risk for CVD decreased from 13.3 ± 8.2 % in 2007 to 11.7 ± 9.0 % in 2012 in men and from 8.0 ± 4.1 % to 5.9 ± 3.4 % in women. The 10-year risk of fatal CVD based on the European Systematic COronary Risk Evaluation (SCORE decreased in men and in women (p <0.0001.Over a 6-year period, several CVRFs have decreased in our screening campaign, leading to decrease in the 10-year risk for CVD and the 10-year risk of fatal CVD. Cardiologists should recognize the importance of community prevention programs and communication policies, particularly tobacco control and healthier diets to decrease the CVRFs in the general population.

  14. The 10-Year Local Recurrence and Partial Breast Radiotherapy for Early Breast Cancer Treated by Conservative Surgery

    Zhizhen Wang; Ruiying Li

    2006-01-01

    OBJECTIVE To study the local recurrence and the role of whole breast radiotherapy for early breast cancer treated by conservative surgery.METHODS From April 1990 to December 2000, 49 patients with early primary breast cancer were treated by conservative surgery in our hospital. The cases were comprised of Stage 0, 1; Stage Ⅰ, 31; and Stage Ⅱa,17. Forty cases underwent quadrantectomy plus axillary lymph node dissection, and the other 9 cases had lumpectomy alone. Irradiation, which was received by 39 patients, was administered by using low tangential half fields with 6 MV X-ray to decrease the pulmonary irradiative volume.The dose to the whole breast was 45 Gy/22~23f/4.5W, then a 15 Gy boost dose was delivered to the tumor bed by an electron beam. The other patients underwent an irradiated regional field according to postoperative pathology.RESULTS All patients were followed-up for 10 years or more. The 10year local recurrence rates, distant metastasis rates and survival rates were 6.1%, 4.1% and 98.0% respectively. All of the 3 patients who had a local recurrence had infiltrative carcinomas and negative lymph nodes.The 10-year local recurrence rate was higher (2.6% vs. 20.0%) with nonpostoperative whole breast radiotherapy, but the statistical difference was not marked because of the low number of cases. All of the recurrent lesions localized within 3 cm of the primary lesion.CONCLUSION Original recurrence of the tumor was the main type of local recurrence. Radiotherapy after conservative surgery is very essential.After conservative surgery it is feasible that irradiation can be delivered alone to the neighboring region of the tumor bed. Partial breast radiotherapy can substitute for whole breast radiotherapy.

  15. Antioxidants and breast cancer risk- a population-based case-control study in Canada

    Morrison Howard

    2011-08-01

    Full Text Available Abstract Background The effect of antioxidants on breast cancer is still controversial. Our objective was to assess the association between antioxidants and breast cancer risk in a large population-based case-control study. Methods The study population included 2,362 cases with pathologically confirmed incident breast cancer (866 premenopausal and 1,496 postmenopausal and 2,462 controls in Canada. Intakes of antioxidants from diet and from supplementation as well as other potential risk factors for breast cancer were collected by a self-reported questionnaire. Results Compared with subjects with no supplementation, 10 years or longer supplementation of zinc had multivariable-adjusted odds ratios (OR and 95% confidence intervals (CI of 0.46 (0.25-0.85 for premenopausal women, while supplementation of 10 years or longer of multiple vitamin, beta-carotene, vitamin C, vitamin E and zinc had multivariable-adjusted ORs (95% CIs of 0.74 (0.59, 0.92, 0.58 (0.36, 0.95, 0.79 (0.63-0.99, 0.75 (0.58, 0.97, and 0.47 (0.28-0.78, respectively, for postmenopausal women. No significant effect of antioxidants from dietary sources (including beta-carotene, alpha-carotene, lycopene, lutein and zeaxanthin, vitamin C, vitamin E, selenium and zinc or from supplementation less than 10 years was observed. Conclusions This study suggests that supplementation of zinc in premenopausal women, and supplementation of multiple vitamin, beta-carotene, vitamin C, vitamin E and zinc in postmenopausal women for 10 or more years may protect women from developing breast cancer. However, we were unable to determine the overall effect of total dose or intake from both diet and supplement.

  16. Nationwide and population-based prescription patterns in bipolar disorder

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2016-01-01

    OBJECTIVES: The aim of the present study was to describe prescription patterns and changes in these patterns over the last decade for patients diagnosed with bipolar disorder in mental healthcare, using population-based and nationwide data, and to relate the findings to recommendations from...... international guidelines. METHODS: A population-based, nationwide study was carried out. It included register-based longitudinal data on all patients with a first-ever contact with mental healthcare with a diagnosis of mania/bipolar disorder from the entire Danish population, and all prescription data for this...

  17. Performance of the RSG-Gas heat exchanger after 10 years of operation

    The calculation of heat exchanger heat transfer coefficient is one of scientific ways to analyze reliability of the heat exchanger. This coefficient is influenced by faulting factor as deposit consequence due to unqualified secondary cooling water. After 10 years of operation, the heat exchanger JE01 BC001/002 has never been visually inspected for corrosion detection. This research evaluated heat Exchanger after 10 years of operation using log mean temperature differential method to calculate its heat transfer coefficient decrease from 17.605 to 11.108 k. cal/( hoC m2)

  18. 30 September 2015: 10 years after the Danish Muhammad cartoons controversy

    Vinding, Niels Valdemar

    2015-01-01

    Today, 30 September 2015, we observe the 10 year anniversary of the publications of 12 editorial cartoons in Jyllands-Posten. The cartoons were originally commissioned as an attempt to contribute to the debate about legitimate criticism of Islam, freedom of speech and self-censorship. Today, the...... debate continues in Denmark and it focuses on three things; firstly, what is the state of freedom of expression today in Denmark especially when it comes to religion, and in relation, secondly, should editors re-run the cartoons on the occasion of the 10 year anniversary, and thirdly should teachers in...

  19. Survival rate in nasopharyngeal carcinoma improved by high caseload volume: a nationwide population-based study in Taiwan

    Chou Pesus

    2011-08-01

    Full Text Available Abstract Background Positive correlation between caseload and outcome has previously been validated for several procedures and cancer treatments. However, there is no information linking caseload and outcome of nasopharyngeal carcinoma (NPC treatment. We used nationwide population-based data to examine the association between physician case volume and survival rates of patients with NPC. Methods Between 1998 and 2000, a total of 1225 patients were identified from the Taiwan National Health Insurance Research Database. Survival analysis, the Cox proportional hazards model, and propensity score were used to assess the relationship between 10-year survival rates and physician caseloads. Results As the caseload of individual physicians increased, unadjusted 10-year survival rates increased (p p = 0.001 after adjusting for comorbidities, hospital, and treatment modality. When analyzed by propensity score, the adjusted 10-year survival rate differed significantly between patients treated by high-volume physicians and patients treated by low/medium-volume physicians (75% vs. 61%; p Conclusions Our data confirm a positive volume-outcome relationship for NPC. After adjusting for differences in the case mix, our analysis found treatment of NPC by high-volume physicians improved 10-year survival rate.

  20. Survival rate in nasopharyngeal carcinoma improved by high caseload volume: a nationwide population-based study in Taiwan

    Positive correlation between caseload and outcome has previously been validated for several procedures and cancer treatments. However, there is no information linking caseload and outcome of nasopharyngeal carcinoma (NPC) treatment. We used nationwide population-based data to examine the association between physician case volume and survival rates of patients with NPC. Between 1998 and 2000, a total of 1225 patients were identified from the Taiwan National Health Insurance Research Database. Survival analysis, the Cox proportional hazards model, and propensity score were used to assess the relationship between 10-year survival rates and physician caseloads. As the caseload of individual physicians increased, unadjusted 10-year survival rates increased (p < 0.001). Using a Cox proportional hazard model, patients with NPC treated by high-volume physicians (caseload ≥ 35) had better survival rates (p = 0.001) after adjusting for comorbidities, hospital, and treatment modality. When analyzed by propensity score, the adjusted 10-year survival rate differed significantly between patients treated by high-volume physicians and patients treated by low/medium-volume physicians (75% vs. 61%; p < 0.001). Our data confirm a positive volume-outcome relationship for NPC. After adjusting for differences in the case mix, our analysis found treatment of NPC by high-volume physicians improved 10-year survival rate

  1. Spironolactone use and renal toxicity: population based longitudinal analysis.

    Wei, L; Struthers, A D; Fahey, T; Watson, A D; MacDonald, T. M.

    2010-01-01

    Objective To determine the safety of spironolactone prescribing in the setting of the UK National Health Service. Design Population based longitudinal analysis using a record linkage database. Setting Tayside, Scotland. Population All patients who received one or more dispensed prescriptions for spironolactone between 1994 and 2007. Main outcome measures Rates of prescribing for spironolactone, hospital admissions for hyperkalaemia, and hyperkalaemia and renal function without...

  2. PRACTICAL APPLICATION OF POPULATION BASED ANT COLONY OPTIMIZATION ALGORITHM

    Valeeva, A.; Goncharova, Yu

    2013-01-01

    In this paper we consider the Split Delivery Vehicle Routing Problem, which has a wide practical application. The SDVRP is NP-hard problem. We propose a population based ant colony optimization algorithm for solving the SDVRP. Computational experiments for developed algorithm are reported.

  3. 24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured...

  4. Progress in Global Surveillance and Response Capacity 10 Years After Severe Acute Respiratory Syndrome

    2013-04-10

    Dr. Mike Miller reads an abridged version of the Emerging Infectious Diseases' synopsis, Progress in Global Surveillance and Response Capacity 10 Years after Severe Acute Respiratory Syndrome.  Created: 4/10/2013 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 4/11/2013.

  5. Clinical and Radiographic Evaluation of a Resin-Based Root Canal Sealer: 10-Year Recall Data

    Osvaldo Zmener

    2012-01-01

    Full Text Available Objectives. This retrospective clinical and radiographical study evaluated the 10-year outcome of one-visit endodontic treatment with gutta-percha and a methacrylate resin-based sealer. Methods. From an initial sample size of 180 patients, 89 patients with 175 root canals responded to a recall. Treatment outcome was based on predetermined clinical and radiographic criteria. Results. Root canals had been adequately filled to the working length in 80 teeth (89.88%, short in 6 instances (6.74%, while 3 (3.37% with extrusion immediate postoperatively, showed no sealer in periradicular tissues. The difference in the outcomes of treatments with respect to age, gender, preoperative pulp or periapical status, the size of periapical lesions and the type of permanent restorations were not statistically significantly different (>0.05. Overall, 7 (7.86% cases were considered clinically and radiographically a failure. A life table analysis showed a cumulative probability of success of 92.13% after 10 years with a 95% confidence interval of 83.0 to 94.0. Conclusions. The results of this retrospective clinical and radiographical study suggest that the tested methacrylate-resin based sealer used with gutta-percha performed similarly to other root canal sealers over a period 10 years. Clinical Implications. Considering the success rate after 10 years of this methacrylate resin-based sealer can be recommended as an alternative to other commonly used root canal sealers.

  6. Personnel Needs in School Psychology: A 10-Year Follow-Up Study on Predicted Personnel Shortages

    Castillo, Jose M.; Curtis, Michael J.; Tan, Sim Yin

    2014-01-01

    Concerns regarding whether a sufficient supply of school psychologists exists have been evident for decades. Studies have predicted that school psychology would face a critical personnel shortage that would peak in 2010, but continue into the foreseeable future. The current study is a 10-year follow-up investigation based on previously published…

  7. Adolescent Drug Trafficking Trends in the United Kingdom--A 10-Year Retrospective Analysis

    Vale, Ellen Louise Eva; Kennedy, Patrick John

    2004-01-01

    This paper reports data from HM Customs and Excise (HMCE) of recorded cases of adolescent drug trafficking through all sea and air points of entry into the UK over a 10-year period (May 1992-May 2002). We report the characteristics of 38 cases of mixed gender and nationality ranging in age between 13 and 18 years who have been apprehended by HMCE…

  8. 10 years' of asbestos-cement multiple-units pipes. An experience report

    Kanitz, H. (Stadtwerke Bielefeld G.m.b.H. (Germany, F.R.))

    1980-02-01

    A comprehensive review of 10 years' experience with application of asbestos-cement multiple-unit pipes (Wanit system) in the Bielefeld municipal works is presented. Attention is drawn to the cost and time saving when compared with laying in hooded channels, and a detailed description of the system and of its application and laying technique are given.

  9. 10 Year trend of levels of organochlorine pollutants in Antarctic seabirds

    Brink, van den N.W.

    2003-01-01

    Contaminants like PCBs and DDE have hardly been used Antarctica. Hence, this is an excellent place to monitor global background levels of these organochlorines. In this project concentrations in penguins and petrels will be compared to 10 years ago, which will show time trends of global background c

  10. Trends for the past 10 years and international comparisons of the structure of Korean radiation oncology

    Study aims include determination of nationwide structural characteristics of radiation oncology facilities, types of radiation therapy equipment, availability of human resources and trends and comparisons with previous surveys. An annual nationwide survey was conducted to collect the statistics of infrastructure since 1997. All requested questionnaires have been identical for 10 years. The questionnaires included status on basic radiation therapy facilities, human resources and radiation therapy equipment. Journal and statistical data reviews were performed to evaluate the structure of other countries. Radiation oncology facilities have steadily increased for 10 years and reached 60 sites in 2006. Also a steady increase of 1.5 times for linear accelerators, 5.8 times for computed tomography simulators and 3.0 times for radiation treatment planning systems was noted. Meanwhile, cobalt-60 teletherapy units and hyperthermia equipment had steadily deceased for 10 years. The number of human resources has steadily increased for the past 10 years, especially for radiation therapy technologists. However, radiation therapy equipment and human resources per population are relatively low compared with advanced countries. This study will assist preparation of the administrative planning policy of radiation oncology and should be useful to indicate the direction of future development and educational training programs in Korea and possibly in other countries. (author)

  11. Cervical involvement in SAPHO syndrome: imaging findings with a 10-year follow-up

    Tohme-Noun, C.; Krainik, A.; Menu, Y. [Department of Radiology, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France); Feydy, A. [Department of Radiology, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France); Department of Radiology, Hopital Beaujon, 100 avenue du General Leclerc, 92118, Clichy (France); Belmatoug, N.; Fantin, B. [Department of Internal Medicine, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France)

    2003-02-01

    Osteoarticular manifestations of SAPHO syndrome include vertebral lesions, typically in the thoracic segment. Chronic inflammatory changes are well depicted by MRI. We report the imaging findings with a 10-year follow-up in a case of SAPHO syndrome with marked cervical lesions. (orig.)

  12. A Model Job Rotation Plan: A 10-Year Follow-up.

    Robinson, Daniel C.; Delbridge-Parker, Linda

    1991-01-01

    Describes model job rotation plan in a college student affairs division in which a staff member (intern) rotates among departments as a staff development opportunity. A 10-year follow-up evaluation underscored the success of the program. Concludes job rotation is not just learning experience, but it is also sharing experience. (Author/ABL)

  13. Effect of meteorology and soil condition on metolachlor and atrazine volatilization over a 10 year period

    A 10-year study was conducted to focus on the impact of soil and climatic factors governing herbicide volatilization from an agricultural field. For the first 5 years, metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] and atrazine [6-chloro-N-ethyl-N’-(1-methyl...

  14. 10-year biochemical (prostate-specific antigen) control of prostate cancer with 125I brachytherapy

    Purpose: To report 10-year biochemical (prostate-specific antigen [PSA]) outcomes for patients treated with 125I brachytherapy as monotherapy for early-stage prostate cancer. Methods and Materials: One hundred and twenty-five consecutively treated patients, with clinical Stage T1-T2b prostate cancer were treated with 125I brachytherapy as monotherapy, and followed with PSA determinations. Kaplan-Meier estimates of PSA progression-free survival (PFS), on the basis of a two consecutive elevations of PSA, were calculated. Aggregate PSA response by time interval was assessed. Comparisons were made to an earlier-treated cohort. Results: The overall PSA PFS rate achieved at 10 years was 87% for low-risk patients (PSA125I achieves a high rate (87%) of biochemical and clinical control in patients with low-risk disease at 10 years. The decline of PSA following brachytherapy with low-dose-rate isotopes can be protracted. Absolute PSA and PFS curves merge, and are comparable at 10 years

  15. 77 FR 11651 - Hybrid III 10-Year-Old Child Test Dummy

    2012-02-27

    ... certification requirements for a new test dummy representative of a 10- year-old child (70 FR 40281, July 13... published July 13, 2005 (70 FR 40281). The agency is concurrently publishing in this issue of the Federal... we published an NPRM to adopt the HIII-10C into FMVSS No. 213.\\1\\ \\1\\ 70 FR 51720 (August 31,...

  16. Parental stress and perceived vulnerability at 5 and 10 years after pediatric SCT

    C.M.J. Vrijmoet-Wiersma; R.M. Egeler; H.M. Koopman; D. Bresters; A.L. Norberg; M.A. Grootenhuis

    2010-01-01

    With the aim of assessing parental stress after SCT, 73 parents of children and adolescents who underwent SCT 5 or 10 years ago responded to questionnaires on general distress (General Health Questionnaire (GHQ)), disease-related stress (Pediatric Inventory for Parents-short form (PIP-SF)) and perce

  17. Parent-Child Relations and Adolescent Self-Image Following Divorce: A 10-Year Study.

    Dunlop, Rosemary; Burns, Ailsa; Bermingham, Suzanne

    2001-01-01

    Explored links between self-image, family structure (divorced or intact), parent-child relations, and gender at 3 intervals over 10 years during adolescence to early adulthood. Results suggest a consistent relationship between high parental care, low overprotective control, and better self-image scores with a stronger effect among subjects from…

  18. Is the Party Over? Cannabis and Juvenile Psychiatric Disorder: The Past 10 Years

    Rey, Joseph M.; Martin, Andres; Krabman, Peter

    2004-01-01

    Objective: To critically review cannabis research during the past 10 years in relation to rates of use, behavioral problems, and mental disorders in young people. Method: Studies published in English between 1994 and 2004 were identified through systematic searches of literature databases. The material was selectively reviewed focusing on child…

  19. Impact of Adolescent Alcohol and Drug Use on Neuropsychological Functioning in Young Adulthood: 10-Year Outcomes

    Hanson, Karen L.; Medina, Krista Lisdahl; Padula, Claudia B.; Tapert, Susan F.; Brown, Sandra A.

    2011-01-01

    Because of ongoing neuromaturation, youth with chronic alcohol/substance use disorders (AUD/SUD) are at risk for cognitive decrements during young adulthood. We prospectively examined cognition over 10 years based on AUD/SUD history. Youth (N = 51) with no AUD/SUD history (n = 14), persisting AUD/SUD (n = 18), or remitted AUD/SUD (n = 19) were…

  20. Cervical involvement in SAPHO syndrome: imaging findings with a 10-year follow-up

    Osteoarticular manifestations of SAPHO syndrome include vertebral lesions, typically in the thoracic segment. Chronic inflammatory changes are well depicted by MRI. We report the imaging findings with a 10-year follow-up in a case of SAPHO syndrome with marked cervical lesions. (orig.)

  1. Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000)

    Wilkinson, J D; Shaw, S; Andersen, Klaus Ejner; Brandao, F M; Bruynzeel, D P; Bruze, M; Camarasa, J M G; Diepgen, T L; Ducombs, G; Frosch, P J; Goossens, A; Lachappelle, J-M; Lahti, A; Menné, T; Seidenari, S; Tosti, A; Wahlberg, J E

    2002-01-01

    A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also...

  2. Higher incidence of rheumatoid arthritis in patients with symptomatic osteoarthritis or osteoarthritis-related surgery: a nationwide, population-based, case–control study in Taiwan

    Lu, Ming-Chi; Liu, Keng-Chang; Lai, Ning-Sheng; Koo, Malcolm

    2015-01-01

    Objectives To investigate the risk of incident rheumatoid arthritis in patients with symptomatic osteoarthritis or osteoarthritis-related surgery using a nationwide health claims database. Design A nationwide, population-based, case–control study. Setting Taiwan's National Health Insurance Research Database. Participants A total of 1147 patients (aged 20–100 years) with rheumatoid arthritis and 5735 controls who were frequency-matched for sex, 10-year age interval and year of catastrophic ill...

  3. International travel and the risk of hospitalization with non-typhoidal Salmonella bacteremia. A Danish population-based cohort study, 1999-2008

    Mølbak Kåre; Ethelberg Steen; Holt Hanne M; Kristensen Brian; Koch Kristoffer; Schønheyder Henrik C

    2011-01-01

    Abstract Background Information is sparse regarding the association between international travel and hospitalization with non-typhoidal Salmonella bacteremia. The aim of this study was to determine the proportion, risk factors and outcomes of travel-related non-typhoidal Salmonella bacteremia. Methods We conducted a 10-year population-based cohort study of all patients hospitalized with non-typhoidal Salmonella bacteremia in three Danish counties (population 1.6 million). We used denominator ...

  4. Haiti's progress in achieving its 10-year plan to eliminate cholera: hidden sickness cannot be cured

    Koski-Karell V

    2016-05-01

    Full Text Available Victoria Koski-Karell,1,2 Paul E Farmer,2–4 Benito Isaac,5 Elizabeth M Campa,5 Loune Viaud,5 Paul C Namphy,6 Ralph Ternier,5 Louise C Ivers2–4 1Department of Anthropology, University of Michigan, and University of Michigan Medical School, Ann Arbor, MI, 2Partners In Health, 3Department of Global Health and Social Medicine, Harvard Medical School, 4Department of Medicine, Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA; 5Zanmi Lasante, Cange, 6Direction Nationale de l'Eau Potable et de l'Assainissement, Port-au-Prince, Haiti Abstract: Since the beginning of the cholera epidemic in Haiti 5 years ago, the prevalence of this deadly water-borne disease has fallen far below the initial rates registered during its explosive outset. However, cholera continues to cause extensive suffering and needless deaths across the country, particularly among the poor. The urgent need to eliminate transmission of cholera persists: compared to the same period in 2014, the first 4 months of 2015 saw three times the number of cholera cases. Drawing upon epidemiology, clinical work (and clinical knowledge, policy, ecology, and political economy, and informed by ethnographic data collected in a rural area of Haiti called Bocozel, this paper evaluates the progress of the nation's 10-year Plan for the Elimination of Cholera. Bocozel is a rice-producing region where most people live in extreme poverty. The irrigation network is decrepit, the land is prone to environmental shocks, fertilizer is not affordable, and the government's capacity to assist farmers is undermined by resource constraints. When peasants do have rice to sell, the price of domestically grown rice is twice that of US-imported rice. Canal water is not only used to irrigate thousands of acres of rice paddies and sustain livestock, but also to bathe, wash, and play, while water from wells, hand pumps, and the river is used for drinking, cooking, and bathing. Only one out of

  5. Population-based register of acute myocardial infarction: manual of operations

    Madsen, Mette; Gudnason, Vilmundur; Pajak, Andrzej;

    2007-01-01

    (including preventive strategies) and clinical decision making with correct cost-benefit assessments.A stepwise surveillance procedure based on standardized data collection, appropriate record linkage and validation methods was set up by the EUROCISS Project (EUROpean Cardiovascular Indicators Surveillance...... model for the implementation of a population-based register. It recommends to start from a minimum data set and then follow a stepwise procedure.Before implementing a population-based register, it is important to identify the target population under surveillance which should preferably cover a well......-defined geographical and administrative area or region representative of the whole country for which population data and vital statistics (mortality and hospital discharge records at minimum) are routinely collected and easily available each year. All cases among residents should be recorded even if the case occurs...

  6. Neonatal outcomes in obese mothers: a population-based analysis

    Minsart Anne-Frederique

    2013-02-01

    Full Text Available Abstract Background If it is well known that obesity increases morbidity for both mother and fetus and is associated with a variety of adverse reproductive outcomes, then few studies have assessed the relation between obesity and neonatal outcomes. This is the aim of the present study after taking into account type of labor and delivery, as well as social, medical and hospital characteristics in a population-based analysis. Methods This study used 2009 data from the Belgian birth register data pertaining to the regions of Brussels and Wallonia and included 38,675 consecutive births. Odds ratio and 95% confidence intervals for admission to neonatal intensive care unit, Apgar score, and perinatal mortality were calculated by logistic regression analyses adjusting for medical, social and hospital characteristics using obesity as the primary independent variable. The impact of analyzing all delivery sites together was tested using mixed-effect analyses. Results The adjusted odds ratio for neonatal intensive care unit admission was higher for obese mothers by 38% compared to non-obese mothers (95% confidence interval (CI: 1.22-1.56, and by 45% (CI: 1.21-1.73 and 34% (CI: 1.10-1.63 after spontaneous and induced labour respectively. The adjusted odds ratio was 1.18 (CI: 0.86-1.63 after caesarean section. The adjusted odds ratio for 1 minute Apgar score inferior to 7 was higher for obese mothers by 31% compared to non-obese mothers (CI: 1.15-1.49 and by 26% (CI: 1.04-1.52 and 38% (CI: 1.12-1.69 after spontaneous and induced labour respectively. The adjusted odds ratio was 1.50 (CI: 0.96-2.36 after caesarean section. The adjusted odds ratio for perinatal mortality was 1.36 (CI: 0.75-2.45 for obese mothers compared to non-obese mothers. Conclusions Neonatal admission to intensive care and low Apgar scores were more likely to occur in infants from obese mothers, both after spontaneous and induced labor.

  7. The Relationship between Emotional Intelligence and Marital Satisfaction: 10-Year Outcome of Partners from Three Different Economic Levels.

    Zohre Nasiri Zarch

    2014-12-01

    Full Text Available Emotional communication and economic factors play an important role in having a satisfying relationship and a more successful marriage. In this regard, we investigated the 10-year outcome of partners from three different economic levels regarding the relationship between emotional intelligence (EI and marital satisfaction.The research was designed as a descriptive-correlative survey and data were analyzed using Pearson correlation test and stepwise regression.Participants were 159 couples (N = 318 who were randomly selected through clustered sampling. The questionnaires included: Bar-on Emotional Intelligence (1997 and Enrich Marital satisfaction (1989.The findings revealed that the average values of emotional intelligence (m = 333.1 and marital satisfaction (m = 300.77 were high in the under-rich region (p<0.05. Moreover, there was no significant relationship between interpersonal and marital satisfaction within the under-rich region. On average, emotional intelligence accounted for 40.8% of marital satisfaction within those three regions (p<0.01.The results of the regression analysis showed that general mood is the most effective factor changing marital satisfaction in the three studied regions (R2= 0.34, rich (R2= 0.42 and semi-rich (R2= 0.52 regions (p<0.01. The most influential factor changing marital satisfaction in the under-rich (R2= 0.28 region was found to be stress management (p<0.01.

  8. A 10-Year Clinical Evaluation of Resin-Bonded Fixed Dental Prostheses on Non-Prepared Teeth.

    Piemjai, Morakot; Özcan, Mutlu; Garcia-Godoy, Franklin; Nakabayashi, Nobuo

    2016-06-01

    This study evaluated the conditions of the non-invasive resin-bonded fixed dental prostheses (FDP) and patient satisfaction up to 10 years of clinical function. A total of 23 patients who required fixed prostheses in the areas of mandibular anterior and premolar, and maxillary anterior region received resin-bonded restorations between 1999-2003. In 13 patients with 14 edentulous areas were restored with an adhesive pontic (natural tooth, acrylic and porcelain). Two indirect proximal veneers using resin composite were placed in each space in 10 patients having 13 edentulous spaces. All prostheses were bonded to the proximal surface of adjacent teeth using resin cement based on 4-META/MMA-TBB. No debonding of proximal veneers but 4 pontic debonding was observed which were rebonded and remained functional until final follow up. The abutments in pontic and proximal veneer groups were free of caries and hypersensitivity. Periodontal health was improved after treatment and was maintained for 10 years except for 4 abutments that still showed some bleeding on probing. Non-invasive resin-bonded FDPs are simple, pain-free, less costly treatment procedures that could provide acceptable clinical longevity with high patient satisfaction. PMID:27424337

  9. Rugby injuries to the cervical spine and spinal cord: a 10-year review.

    Scher, A T

    1998-01-01

    A 10-year review (1987-1996) of injuries sustained to the spine and spinal cord in rugby players with resultant paralysis has been undertaken. This article reviews that the incidence of serious rugby spine and spinal cord injuries in South Africa has increased over the 10-year period reviewed, despite stringent new rules instituted in an attempt to decrease the incidence of these injuries. The mechanisms of injury, as previously reported, remain the same as well as the phases of game responsible for injury of the tight scrum, tackle, rucks, and mauls. Two new observations are reported: the first is related to the occurrence of spinal cord concussion with transient paralysis, and the second is related to the increased incidence of osteoarthritis of the cervical spine in rugby players. PMID:9475983

  10. Prevalence of overweight and obesity in Danish preschool children over a 10-year period

    Larsen, Lone Marie; Hertel, Niels Thomas; Mølgaard, Christian;

    2012-01-01

    Aim:  To determine change in the prevalence of overweight and obesity in preschool children, over a 10-year period and to identify possible predictors of overweight in 5-year-old children. Methods:  Anthropometric data from birth and routine child health examinations at 3 and 5 years of age...... performed in general practice were collected in 5580 children from two Funen birth cohorts (1992 and 2001, respectively) representing 48% of the total population at similar age. The prevalence of overweight and obesity was classified using the IOTF definitions. Results:  In a Danish representative survey...... of preschool children, the average BMI and prevalence of overweight and obesity did not vary significantly during the 10-year period. No significant changes in mean birth weight were registered and mean BMI in the group of obese children did not increase. Overweight or obesity at 5 years was strongly...

  11. Physical aggression, compromised social support, and 10-year marital outcomes: Testing a relational spillover model.

    Sullivan, Kieran T; Pasch, Lauri A; Lawrence, Erika; Bradbury, Thomas N

    2015-12-01

    The purpose of the present study was to test a relational spillover model of physical aggression whereby physical aggression affects marital outcomes due to its effects on how spouses ask for and provide support to one another. Newlywed couples (n = 172) reported levels of physical aggression over the past year and engaged in interactions designed to elicit social support; marital adjustment, and stability were assessed periodically over the first 10 years of marriage. Multilevel modeling revealed that negative support behavior mediated the relationship between physical aggression and 10-year marital adjustment levels whereas positive support behavior mediated the relationship between physical aggression and divorce status. These findings emphasize the need to look beyond conflict when explaining how aggression affects relationships and when working with couples with a history of physical aggression who are seeking to improve their relationships. PMID:26168263

  12. 10 Years of Public Administration at Babes-Bolyai University, Cluj-Napoca

    The Editors

    2006-01-01

    Fall 2006: The Public Administration Department, Faculty of Political Sciences, Public Administration, and Communication celebrates 10 years of existence. The department will organize an international conference called “The contribution of higher education in the field of public administration to the reform of public administration”. Thus, from October 6th to October 11th the foreign partners who have contributed over the years to the development of the department will attend the conference.

  13. Immunofluorescence testing in the diagnosis of autoimmune blistering diseases: overview of 10-year experience*

    Arbache, Samia Trigo; Nogueira, Tarsila Gasparotto; Delgado, Lívia; Miyamoto, Denise; Aoki, Valéria

    2014-01-01

    BACKGROUND Immunofluorescence testing is an important tool for diagnosing blistering diseases. OBJECTIVE To characterize the immunofluorescence findings in patients diagnosed with autoimmune blistering skin diseases. METHODS We retrospectively analyzed immunofluorescence results encompassing a 10-year period. RESULTS 421 patients were included and divided into 2 groups: group 1- intraepidermal blistering diseases (n=277) and 2- subepidermal blistering diseases (n=144). For group 1, positive D...

  14. An Analysis of China's Stock Market in the First 10 Years

    Siwei Cheng

    2009-01-01

    The purpose of this paper is to provide a systematic analysis of the development of the Chinese stock market in the first 10 years. It can be a lesson to both researchers and investors on China's stock market. In this paper, the author first shares his own experience from involvement in policy making and regulation inspections in developing China's stock market. Then, based on observations at the market as well as academic research findings that he conducted with his colleagues, the author di...

  15. Changes in Pulmonary Function Up to 10 Years After Locoregional Breast Irradiation

    Erven, Katrien, E-mail: Katrien.erven@uzleuven.be [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium); Weltens, Caroline [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium); Nackaerts, Kristiaan [Department of Pulmonology, University Hospital Gasthuisberg, Leuven (Belgium); Fieuws, Steffen [I-BioStat, Catholic University Leuven and Hasselt University, Leuven (Belgium); Decramer, Marc [Department of Pulmonology, University Hospital Gasthuisberg, Leuven (Belgium); Lievens, Yolande [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium)

    2012-02-01

    Purpose: To evaluate the long-term impact of locoregional breast radiotherapy (RT) on pulmonary function tests (PFTs). Methods and Materials: This study included 75 women who underwent postoperative locoregional breast RT. PFTs were performed before RT and 3, 6, and 12 months and 8 to 10 years after RT. By use of univariate and multivariate analyses, the impact of treatment- and patient-related factors on late changes in PFTs was evaluated. Results: During the first year after RT, all PFTs significantly worsened at 3 to 6 months after RT (p < 0.05). At 12 months, forced vital capacity (FVC), vital capacity (VC), and forced expiratory volume in 1 second (FEV{sub 1}) recovered almost to baseline values, whereas total lung capacity (TLC) and diffusion capacity of carbon monoxide (DL{sub CO}) recovered only slightly and were still found to be decreased compared with baseline (p < 0.05). At 8 to 10 years after RT, mean reductions in FEV{sub 1} of 4% (p = 0.03) and in VC, DL{sub CO}, and TLC of 5%, 9%, and 11% (all p < 0.0001), respectively, were observed compared with pre-RT values. On multivariate analysis, tamoxifen use negatively affected TLC at 8 to 10 years after RT (p = 0.033), whereas right-sided irradiation was associated with a late reduction in FEV{sub 1} (p = 0.027). For FEV{sub 1} and DL{sub CO}, an early decrease was predictive for a late decrease (p = 0.003 and p = 0.0009, respectively). Conclusions: The time course of PFT changes after locoregional RT for breast cancer follows a biphasic pattern. An early reduction in PFTs at 3 to 6 months with a partial recovery at 12 months after RT is followed by a late, more important PFT reduction up to 8 to 10 years after RT. Tamoxifen use may have an impact on this late decline in PFTs.

  16. Deaths in the Cook County Jail: 10-Year Report, 1995–2004

    Kim, Seijeoung; Ting, Andrew; Puisis, Michael; Rodriguez, Sergio; Benson, Roger; Mennella, Connie; Davis, Faith

    2006-01-01

    The aims of this study were to describe causes of death during the 10-year period between 1995 and 2004 in a large urban jail in Chicago; to compare disease specific mortality rates between the jail population and the general population; to explore demographic and incarceration characteristics of the inmates who died in the jail by cause of death; and to examine gender difference in demographic characteristics, incarceration patterns, and causes of death. A total of 178 deaths occurring in th...

  17. REACTIVE AND PROACTIVE AGGRESSION IN ADOLESCENT MALES: Examining Differential Outcomes 10 Years Later in Early Adulthood

    Fite, Paula J.; Raine, Adrian; Stouthamer-Loeber, Magda; Loeber, Rolf; Pardini, Dustin A.

    2009-01-01

    There is limited knowledge about the unique relations between adolescent reactive and proactive aggression and later psychosocial adjustment in early adulthood. Accordingly, this study prospectively examined associations between adolescent (mean age = 16) reactive and proactive aggression and psychopathic features, antisocial behavior, negative emotionality, and substance use measured 10 years later in early adulthood (mean age = 26). Study questions were examined in a longitudinal sample of ...

  18. A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants

    Chang, Chin-Chun; Cheng, Chih-Jen; Sung, Chih-Chien; Chiueh, Tzong-Shi; Lee, Chien-Hsing; Chau, Tom; Lin, Shih-Hua

    2013-01-01

    Background A comprehensive analysis has not been performed on patients with thyrotoxic periodic paralysis (TPP) characterized by acute hypokalemia and paralysis in the setting of thyrotoxicosis. Purpose The aim of this study was to analyze the detailed symptomatology of thyrotoxicosis and precipitating factors for the attack in a large cohort of TPP patients. Patients and methods A prospective observational study enrolled patients with TPP consecutively over 10 years at an academic medical ce...

  19. Accomplishment of 10-year research in NUCEF and future development. Process safety and development research

    Researches on process safety of reprocessing, development of an advanced reprocessing and partitioning of high-level liquid waste(HLLW) have been conducted in NUCEF - BECKY (Back-end Fuel Cycle Key Elements Research Facility), which has α-γ concrete cells and many glove-boxes. This paper present 10 year accomplishment of the above researches and future activities to be conducted in the field of separation process development. (author)

  20. The Future of Federated Search, or What Will the World Look like in 10 Years

    Turner, Rich

    2009-01-01

    In this article, the author contends that in 10 years, federated search--or search of any kind for that matter--won't exist. He elaborates that the "function" of search will exist--but not in a context with which anyone is familiar today. So if "search" doesn't exist in 2018, how will people find the information that they need across vast volumes…

  1. Children of Treated Substance-abusing Mothers: A 10-year Prospective Study

    Hser, Y.; Evans, E.; Li, L.; Metchik, A.; Messina, N

    2013-01-01

    The study examined children of substance-abusing mothers approximately 10 years after mothers’ admission to drug abuse treatment, and identified maternal characteristics that may be risk factors for child behavior problems on the Child Behavior Checklist (CBCL). Data were obtained from 396 mothers who were included in a sample consecutively admitted to 44 treatment programs in 13 California counties during 2000–2002. Addiction Severity Index was administered at both intake and follow-up. Each...

  2. Pulmonary alveolar proteinosis in a 10-year-old girl masquerading as tuberculosis

    Baro, Abhamoni; Shah, Ira; Chandane, Parmarth; Khosla, Indu

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. Diagnosis is established by bronchoalveolar lavage (BAL), which has macroscopic ‘milky appearance’, and in the presence of typical computed tomography, findings are diagnostic of PAP but, however, the feature of periodic acid–Schiff-positive eosinophilic proteinaceous fluid raises the confidence of the diagnosis. We report late-onset PAP in a 10-year-old girl who had acid fast bacilli on an initial BAL examination, but was subs...

  3. Book Review --India Port Report: 10 Years of Reforms and Challenges Ahead

    Deepak Kumar

    2005-01-01

    India Port report by I-maritime, Mumbai presents a broader prospect of Indian port sector with a public policy prospective and has integrated focal points of different business entity like, shipping lines, port authority, port operators, logistics agencies and types of cargo transported by individual ports. This report has discussed the port history before and after the liberalized era and has broadly discussed the 10 years of the reforms and challenges ahead. The report says that the problem...

  4. Effect of Metronidazole on Halitosis of 2 to 10 Years Old Children

    Sayedi, Sayed Javad; Modaresi, Mohammad Reza; Saneian, Hosein

    2015-01-01

    Background: Regarding the fact that halitosis has social and personal aspects which can lead to social embarrassment and consequently low self-esteem and self-confidence in subjects suffering from the problem, especially children, its proper treatment is an important issue. Objectives: The aim of this study was to evaluate the effect of metronidazole as a nonspecific antimicrobial agent in the treatment of halitosis in children. Materials and Methods: In this study, 2-10 years old children wi...

  5. Retinopathy of Prematurity: An Evaluation in the Keelung Area of Taiwan over A 10- Year Period.

    Ko-Jen Yang; Chen-Hsin Tsai; Chi-Chun Lai; Chia-Shun Lu; Tun-Lu Chen

    2005-01-01

    Background: We report on the experience of retinopathy of prematurity (ROP) at ChangGang Memorial Hospital (CGMH), Keelung, Taiwan over a 10-year period.Methods: A retrospective review was made of data of all premature infants with a diagnosisof ROP at Keelung CGMH between 1994 and 2003. Data on certaincharacteristics including gender, gestational age (GA), birth body weight(BBW), stage of ROP, and treatment modalities were collected and analyzed.Results: Among the 458 infants screened for RO...

  6. Psychological Factors Predict Eating Disorder Onset and Maintenance at 10-year Follow-up

    Holland, Lauren A.; Bodell, Lindsay P.; Keel, Pamela K.

    2013-01-01

    The present study sought to identify psychological factors that predict onset and maintenance of eating disorders. Secondary analyses were conducted using data from an epidemiological study of health and eating behaviors in men and women (N=1320; 72% female) to examine the prospective and independent influence of the Eating Disorder Inventory (EDI) Perfectionism, Interpersonal Distrust, and Maturity Fears subscales in predicting the onset and maintenance of eating disorders at 10-year follow-...

  7. Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

    Otsuka, R; Tange, C; Nishita, Y; Kato, Y.; Imai, T.; Ando, F; Shimokata, H.

    2014-01-01

    Background/Objectives: To clarify the association of serum docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels with cognitive decline over 10 years. Subjects/Methods: This study was part of the National Institute for Longevity Sciences - Longitudinal Study of Aging, and was conducted with 232 male and 198 female Japanese community-dwelling subjects aged 60–79 years in the second wave (2000–2002). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) in bo...

  8. Prospective Predictors of Body Dissatisfaction in Young Adults: 10-year Longitudinal Findings

    Quick, Virginia; Eisenberg, Marla E.; Bucchianeri, Michaela M.; Neumark-Sztainer, Dianne

    2013-01-01

    This study identified longitudinal risk factors for body dissatisfaction (BD) over a 10-year period from adolescence to young adulthood. Participants (N = 2134; age at baseline: M =15.0, SD =1.6 years) provided two waves of survey data. A 6-step hierarchical linear regression analysis examined the predictive contribution of Time 1 BD, weight status, demographics, family and peer environmental factors, and psychological factors. Among females, Asian race/ethnicity, low sel...

  9. Laboratory investigation of monoclonal gammopathy during 10 years of screening in a general hospital.

    V. Malacrida; De Francesco, D.; Banfi, G; Porta, F A; Riches, P G

    1987-01-01

    Protein electrophoresis was carried out on 102,000 samples from the patients of a district general hospital over 10 years, and a monoclonal protein was detected in 730 cases; of these, 114 could be classified as B cell malignancies and 261 as monoclonal gammopathy of undefined significance (MGUS). The various clinical and laboratory features of monoclonal gammopathy were examined with respect to distinguishing the malignant conditions from MGUS at first presentation.

  10. 10 years with grey literature at Tomas Bata University in Zlín

    Budínský, Lukáš; Fabián, Ondřej

    2016-01-01

    The Library of Tomas Bata University in Zlín has been working on accessioning academic grey literature systematically for the last 10 years. During this time, one of the first information systems storing theses and dissertations changed from a closed, manually updated system into a fully automated and fully open repository with a number of integrations with both internal and external systems. New types of documents were added and several services were introduced for working with grey literatu...

  11. CT localisation of an aldosteronoma in a 10-year-old boy

    An adrenal adenoma is a rare cause of primary aldosteronism in children but very important to diagnose as the cure rate is 100% by surgery. The advent of high resolution CT scanners should facilitate very much the role of the radiologist and diminish the delay of diagnosis. We report the case of a 10-year-old boy with such an entity where the aldosteronoma was shown by CT pre-operatively. (orig.)

  12. Report on the first 10 years of the emerging markets corporate governance research network (EMCGN)

    Ararat, Melsa; Claessens, Stijn; Yurtoğlu, B. Burçin; Yurtoglu, B. Burcin

    2014-01-01

    This paper provides an account of the Emerging Markets Corporate Governance Research Network (EMCGN)and its first 10 years of activities. The Network was established under the auspices of the Global Corporate Governance Forum (now incorporated into IFC’s Corporate Governance Group). The paper describes the history of the EMCGN and its objective (to stimulate research focused on corporate governance in emergingmarkets as well as transition and developing countries); its structure, which is a j...

  13. Postoperative intussusception in 10-year-old presenting as decreased intestinal motility

    Arielle Spellun; Loren Berman; Stephen Murphy

    2016-01-01

    Postoperative intussusception is a rare surgical complication. It typically presents as bilious emesis with abdominal pain following a symptom-free period within two weeks of either intra or extra-abdominal surgery. We present the case of a 10-year-old boy who had undergone uncomplicated open appendectomy. He developed abdominal pain, bilious vomiting and tenesmus at one week post-operatively, and postoperative intussusception was suspected. At laparotomy, he was noted to have an ileal–ileal ...

  14. Service-Learning Center celebrates 10 years of university-community partnership

    Felker, Susan B.

    2005-01-01

    The Virginia Tech Service-Learning Center will celebrate 10 years of helping faculty and students put knowledge to work through community service with a banquet from 5:30 to 9 p.m. Wednesday, April 27, at the Donaldson Brown Hotel and Conference Center, Otey Street, on Virginia Tech's campus. Tickets are $35 per person with proceeds benefiting the Service-Learning Center.

  15. Preoperative Nomogram Predicting the 10-Year Probability of Prostate Cancer Recurrence After Radical Prostatectomy

    Stephenson, Andrew J.; Scardino, Peter T.; Eastham, James A.; Bianco, Fernando J.; Dotan, Zohar A.; Fearn, Paul A.; Michael W Kattan

    2006-01-01

    An existing preoperative nomogram predicts the probability of prostate cancer recurrence, defined by prostate-specific antigen (PSA), at 5 years after radical prostatectomy based on clinical stage, serum PSA, and biopsy Gleason grade. In an updated and enhanced nomogram, we have extended the predictions to 10 years, added the prognostic information of systematic biopsy results, and enabled the predictions to be adjusted for the year of surgery. Cox regression analysis was used to model the cl...

  16. Aggression and violence among Iranian adolescents and youth: A 10-year systematic review

    Saeid Sadeghi; Ziba Farajzadegan; Roya Kelishadi; Kamal Heidari

    2014-01-01

    Background: Although the overwhelming majority of Iranian adolescents are well-adjusted, a substantial group exhibits high levels of maladjustment and deficient functioning. Escalation of criminal violence among the youth population has become a major public policy issue and a serious public health problem. In reviewing a 10-year literature, this article aimed to describe and propose primary assumptions regarding the correlates of aggressive and violent behaviors in Iranian adolescents and yo...

  17. Stress Generation, Avoidance Coping, and Depressive Symptoms: A 10-Year Model

    Holahan, Charles J.; Moos, Rudolf H; Holahan, Carole K.; Brennan, Penny L.; Schutte, Kathleen K.

    2005-01-01

    This study examined (a) the role of avoidance coping in prospectively generating both chronic and acute life stressors and (b) the stress-generating role of avoidance coping as a prospective link to future depressive symptoms. Participants were 1,211 late-middle-aged individuals (500 women and 711 men) assessed 3 times over a 10-year period. As predicted, baseline avoidance coping was prospectively associated with both more chronic and more acute life stressors 4 years later. Furthermore, as ...

  18. Pediatric pulmonary hodgkin lymphoma: Analysis of 10 years data from a single center

    Urasinski, T; Kamienska, E; Gawlikowska-Sroka, A; Ociepa, T; Maloney, E.; Chosia, K; Walecka, A

    2010-01-01

    Several reports indicate that lungs are the extralymphatic site most commonly affected in patients with Hodgkin lymphoma; however, the data in children are rather limited. This retrospective study aimed to assess the frequency, clinical picture, and the impact on prognosis in children with pulmonary Hodgkin lymphoma, who were diagnosed and treated in a single center during a 10-year period. Pulmonary lesions related to HL: nodules and parenchymal infiltrates with cavitations were found in 3 o...

  19. National population-based biobanks for genetic research.

    Swede, Helen; Stone, Carol L; Norwood, Alyssa R

    2007-03-01

    Clinical practice guidelines derived from genetic research using population-based biobanks could dramatically change the nature of personal and public health medicine. Centralized population-based biobanks have been established or proposed in at least nine countries to date, and many lessons have been learned from these landmark developments. Scientific and governmental leaders in the United States are currently contemplating pending federal legislation regarding the establishment of centralized and networked biobanks. Public health practitioners and clinical care providers may be called on to serve pronounced planning roles at the state level. Possible responsibilities include: formulating legislation, gathering public comment, reviewing research proposals, and developing procedures for informed consent, participant withdrawal, and confidentiality protection. State health agencies may also need to create and/or administer banking facilities. Proper planning may ensure that individual rights are protected while research benefits are maximized. PMID:17413418

  20. A 10-year review of the dose history of radiation workers in the University of Surrey

    This thesis presents data on internally and externally received doses for radiation workers whose records are kept at the Safety Office of the University of Surrey for the period 1981-1990. The distribution of doses by range is presented and analysed. The patterns of the collective equivalent dose (CED) and the average individual equivalent dose (IED) over the 10-year period are presented. The annual CED is very low, so that even the total for the 10-year period is less than 1 man-Sv. Likewise, the annual average IED is extremely low, well below the average annual dose to the U.K. population from overall sources of ionising radiation. Some relevant aspects of the 1990 ICRP Recommendations are examined and the impact of these to the 'practices' and sources of ionising radiation in the University is given consideration. The results of the 10-year review provide more evidence of over designation of radiation workers in the University. A recommendation is made to reduce the number of workers who are routinely monitored and justification and options are presented. This study is viewed as a useful database which could be of particular importance in the procedure of optimisation of radiation protection in the University of Surrey and U.K. establishments for higher education as a whole. (author)

  1. One-Month to 10-Year Survival in the Copenhagen Stroke Study

    Andersen, Klaus Kaae; Olsen, Tom Skyhøj

    2011-01-01

    .0 years; 56% women; mean Scandinavian Stroke Scale [SSS], 38.0 ± 17.4). Evaluation included stroke severity (based on the SSS), computed tomography scan, and a cardiovascular risk profile. Using logistic regression models, we examined the relevance of the SSS on mortality at 1 month and 1, 5, and 10 years....... We analyzed the proportion of the variation explained by the models and bias of risk factors estimates with and without the SSS in the model. Mortality rate was 16.6% at 1 month, 31.5% at 1 year, 60.2% at 5 years, and 81.3% at 10 years. In models including the SSS, 22.4%, 20.9%, 32.8%, and 39.5% of...... the variance was explained for the endpoints of 1 month, 1 year, 5 years, and 10 years, respectively. When SSS was left out of the model, the corresponding values were 6.9%, 13.3%, 29.0%, and 35.1%. Factors significantly associated with survival were SSS at 1 month; SSS, age, diabetes, and stroke type...

  2. Parental stress and perceived vulnerability at 5 and 10 years after pediatric SCT.

    Vrijmoet-Wiersma, C M J; Egeler, R M; Koopman, H M; Bresters, D; Norberg, A L; Grootenhuis, M A

    2010-06-01

    With the aim of assessing parental stress after SCT, 73 parents of children and adolescents who underwent SCT 5 or 10 years ago responded to questionnaires on general distress (General Health Questionnaire (GHQ)), disease-related stress (Pediatric Inventory for Parents-short form (PIP-SF)) and perceptions of child vulnerability (Child Vulnerability Scale (CVS)). General distress scores were comparable with the reference groups, but 40% of the mothers at 5 years after SCT reported increased stress levels as compared with 26% in the community-based reference group. Disease-related stress was comparable with the reference group of parents of children who were just off cancer treatment, 5 years after SCT. At 10 years after SCT, scores were lower than the reference group. Perceived child vulnerability did diminish over time, but remained high in parents of SCT survivors, compared with parents of healthy children: 96% of the parents at 5 years after SCT and 76% of the parents at 10 years after SCT scored above the cutoff point. Perceived vulnerability was found to be a predictor for parental disease-related stress. To conclude, although most parents of SCT survivors are resilient, the majority of parents perceive their child to be much more vulnerable as compared with parents of healthy children. This perception is associated with disease-related stress and may induce overprotective parenting. PMID:19881554

  3. Structural model of in-group dynamic of 6-10 years old boys’ motor fitness

    Ivashchenko O.V.

    2015-10-01

    Full Text Available Purpose: to determine structural model of in-group dynamic of 6-10 years old boys’ motor fitness. Material: in the research 6 years old boys (n=48, 7 years old (n=45, 8 years old (n=60, 9 years’ age (n=47 and10 years’ age (n=40 participated. We carried out analysis of factorial model of schoolchildren’s motor fitness. Results: we received information for taking decisions in monitoring of physical education. This information is also necessary for working out of effective programs of children’s and adolescents’ physical training. We determined model of motor fitness and specified informative tests for pedagogic control in every age group. In factorial model of boys’ motor fitness the following factor is the most significant: for 6 years - complex development of motor skills; for 7 years - also complex development of motor skills; for 8 years - strength and coordination; for 9 years - complex development of motor skills; for 10 years - complex development of motor skills. Conclusions: In factorial model of 6-10 years old boys’ motor fitness the most significant are backbone and shoulder joints’ mobility, complex manifestation of motor skills, motor coordination. The most informative tests for assessment of different age boys’ motor fitness have been determined.

  4. The Impact of Hypofractionated Whole Breast Radiotherapy on Local Relapse in Patients With Grade 3 Early Breast Cancer: A Population-Based Cohort Study

    Herbert, Christopher, E-mail: cherbert@bccancer.bc.ca [Department of Radiation Oncology, BC Cancer Agency, Vancouver, British Columbia (Canada); Nichol, Alan [Department of Radiation Oncology, BC Cancer Agency, Vancouver, British Columbia (Canada); Olivotto, Ivo [Department of Radiation Oncology, BC Cancer Agency, Victoria, British Columbia (Canada); Weir, Lorna [Department of Radiation Oncology, BC Cancer Agency, Vancouver, British Columbia (Canada); Woods, Ryan; Speers, Caroline [Breast Cancer Outcomes Unit, BC Cancer Agency, Vancouver, British Columbia (Canada); Truong, Pauline [Department of Radiation Oncology, BC Cancer Agency, Victoria, British Columbia (Canada); Tyldesley, Scott [Department of Radiation Oncology, BC Cancer Agency, Vancouver, British Columbia (Canada)

    2012-04-01

    Purpose: To determine whether patients with Grade 3 early breast cancer have an inferior rate of local disease control at 10 years with hypofractionated radiotherapy compared with more conventionally fractionated schedules. Methods and Materials: Local relapse rates were compared between patients receiving hypofractionated radiotherapy or conventionally fractionated radiotherapy to the whole breast in a population-based cohort of women with early-stage (T1-T2, N0, M0) Grade 3 breast cancers diagnosed between 1990 and 2000 and referred to the British Columbia Cancer Agency. Cumulative rates of local relapse were estimated using a competing risk method, and factors significant on univariate analysis were included with fractionation group in a multivariate model. The primary end point was local control at 10 years. Results: A total of 1,335 patients with Grade 3 tumors were treated with adjuvant radiotherapy, 252 with conventional fractionation, and 1,083 with a hypofractionated schedule. The 10-year cumulative incidence of local relapse was 6.9% in the hypofractionated group and 6.2% in the conventionally fractionated group (p = 0.99). Conclusions: There is no evidence that hypofractionation is inferior to conventional fractionation for breast conserving therapy in patients with Grade 3 breast cancer in this large population-based series after 10 years of follow-up.

  5. The Impact of Hypofractionated Whole Breast Radiotherapy on Local Relapse in Patients With Grade 3 Early Breast Cancer: A Population-Based Cohort Study

    Purpose: To determine whether patients with Grade 3 early breast cancer have an inferior rate of local disease control at 10 years with hypofractionated radiotherapy compared with more conventionally fractionated schedules. Methods and Materials: Local relapse rates were compared between patients receiving hypofractionated radiotherapy or conventionally fractionated radiotherapy to the whole breast in a population-based cohort of women with early-stage (T1-T2, N0, M0) Grade 3 breast cancers diagnosed between 1990 and 2000 and referred to the British Columbia Cancer Agency. Cumulative rates of local relapse were estimated using a competing risk method, and factors significant on univariate analysis were included with fractionation group in a multivariate model. The primary end point was local control at 10 years. Results: A total of 1,335 patients with Grade 3 tumors were treated with adjuvant radiotherapy, 252 with conventional fractionation, and 1,083 with a hypofractionated schedule. The 10-year cumulative incidence of local relapse was 6.9% in the hypofractionated group and 6.2% in the conventionally fractionated group (p = 0.99). Conclusions: There is no evidence that hypofractionation is inferior to conventional fractionation for breast conserving therapy in patients with Grade 3 breast cancer in this large population-based series after 10 years of follow-up.

  6. Epilepsy in Children With ADHD: A Population-Based Study

    Davis, Shanlee M.; Katusic, Slavica K.; Barbaresi, William J.; Killian, Jill; Weaver, Amy L.; Ottman, Ruth; Wirrell, Elaine C.

    2010-01-01

    Prior studies suggest a higher incidence of symptoms of attention-deficit/hyperactivity disorder in children with epilepsy, but few have investigated epilepsy in children with attention-deficit/hyperactivity disorder. Our objective was to compare the incidence and characteristics of epilepsy among population-based, research identified cohorts of children with (N=358) and without attention-deficit/hyperactivity disorder (N=728), based on medical record review to age 20. Data abstracted include...

  7. Sleep and Multisystem Biological Risk: A Population-Based Study

    Carroll, Judith E.; Irwin, Michael R.; Merkin, Sharon Stein; Seeman, Teresa E

    2015-01-01

    Background Short sleep and poor sleep quality are associated with risk of cardiovascular disease, diabetes, cancer, and mortality. This study examines the contribution of sleep duration and sleep quality on a multisystem biological risk index that is known to be associated with morbidity and mortality. Methods Analyses include a population-based sample from the Midlife Development in the United States survey recruited to the Biomarker substudy. A total of 1,023 participants aged 54.5 years (S...

  8. Cardiovascular outcomes associated with use of clarithromycin: population based study

    Wong, AY; Root, A.; Douglas, IJ; Chui, CS; Chan, EW; Ghebremichael-Weldeselassie, Y.; Siu, CW; Smeeth, L; Wong, IC

    2016-01-01

    STUDY QUESTION:  What is the association between clarithromycin use and cardiovascular outcomes? METHODS:  In this population based study the authors compared cardiovascular outcomes in adults aged 18 or more receiving oral clarithromycin or amoxicillin during 2005-09 in Hong Kong. Based on age within five years, sex, and calendar year at use, each clarithromycin user was matched to one or two amoxicillin users. The cohort analysis included patients who received clarithromycin (n=108 988) or ...

  9. Cyberbullying among Finnish adolescents – a population-based study

    Lindfors Pirjo L; Kaltiala-Heino Riittakerttu; Rimpelä Arja H

    2012-01-01

    Abstract Background Cyberbullying, threatening or harassing another via the internet or mobile phones, does not cause physically harm and thus the consequences are less visible. Little research has been performed on the occurrence of cyberbullying among adolescents or the perception of its seriousness. Only a few population-based studies have been published, none of which included research on the witnessing of cyberbullying. Here, we examined exposure to cyberbullying during the last year, an...

  10. LGBT Demographics: Comparisons among population-based surveys

    Gates, Gary J.

    2014-01-01

    This report uses four large, national, population-based surveys to consider the ways in which LGBT populations are demographically similar to or distinct from their non-LGBT counterparts in the United States. Comparisons of demographic characteristics are made among the surveys and, when possible, among sexual orientation identities to consider differences between those who identify as lesbian or gay and those who identify as bisexual (none of the surveys allow for separate identification of ...

  11. Anxiety disorders in young people: a population-based study

    Thaíse Campos Mondin; Caroline Elizabeth Konradt; Taiane de Azevedo Cardoso; Luciana de Avila Quevedo; Karen Jansen; Luciano Dias de Mattos; Ricardo Tavares Pinheiro; Ricardo Azevedo da Silva

    2013-01-01

    Objective: To assess the prevalence of anxiety disorders and associated factors in young adults. Methods: Cross-sectional population-based study of individuals between the ages of 18 and 24 years randomly selected from 89 census-based sectors to ensure an adequate sample size. Household selection within the sectors was performed according to a systematic sampling process. Anxiety disorders were assessed using the Mini International Neuropsychiatric Interview (MINI). The final sample compris...

  12. Screening and cervical cancer cure: population based cohort study

    Andrae, B.; Andersson, T. M.-L.; Lambert, P C; Kemetli, L.; Silfverdal, L.; Strander, B.; Ryd, W; Dillner, J; Tornberg, S; Sparen, P

    2012-01-01

    Objective To determine whether detection of invasive cervical cancer by screening results in better prognosis or merely increases the lead time until death. Design Nationwide population based cohort study. Setting Sweden. Participants All 1230 women with cervical cancer diagnosed during 1999-2001 in Sweden prospectively followed up for an average of 8.5 years. Main outcome measures Cure proportions and five year relative survival ratios, stratified by screening history, mode of detection, age...

  13. Dual sensory impairment in older adults increases the risk of mortality: a population-based study.

    Bamini Gopinath

    Full Text Available Although concurrent vision and hearing loss are common in older adults, population-based data on their relationship with mortality is limited. This cohort study investigated the association between objectively measured dual sensory impairment (DSI with mortality risk over 10 years. 2812 Blue Mountains Eye Study participants aged 55 years and older at baseline were included for analyses. Visual impairment was defined as visual acuity less than 20/40 (better eye, and hearing impairment as average pure-tone air conduction threshold greater than 25 dB HL (500-4000 Hz, better ear. Ten-year all-cause mortality was confirmed using the Australian National Death Index. After ten years, 64% and 11% of participants with DSI and no sensory loss, respectively, had died. After multivariable adjustment, participants with DSI (presenting visual impairment and hearing impairment compared to those with no sensory impairment at baseline, had 62% increased risk of all-cause mortality, hazard ratio, HR, 1.62 (95% confidence intervals, CI, 1.16-2.26. This association was more marked in those with both moderate-severe hearing loss (>40 dB HL and presenting visual impairment, HR 1.84 (95% CI 1.19-2.86. Participants with either presenting visual impairment only or hearing impairment only, did not have an increased risk of mortality, HR 1.05 (95% CI 0.61-1.80 and HR 1.24 (95% CI 0.99-1.54, respectively. Concurrent best-corrected visual impairment and moderate-severe hearing loss was more strongly associated with mortality 10 years later, HR 2.19 (95% CI 1.20-4.03. Objectively measured DSI was an independent predictor of total mortality in older adults. DSI was associated with a risk of death greater than that of either vision loss only or hearing loss alone.

  14. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

    Gert Huppertz-Hauss

    2016-01-01

    Full Text Available Background. The treatment of chronic inflammatory bowel disease (IBD is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D and the Euro QoL (EQ-5D, two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36 was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution.

  15. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

    Aas, Eline; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2016-01-01

    Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36) was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution.

  16. Development of 5- and 10-year-old pediatric phantoms based on polygon mesh surfaces

    Purpose: The purpose of this study is the development of reference pediatric phantoms for 5- and 10-year-old children to be used for the calculation of organ and tissue equivalent doses in radiation protection. Methods: The study proposes a method for developing anatomically highly sophisticated pediatric phantoms without using medical images. The 5- and 10-year-old male and female phantoms presented here were developed using 3D modeling software applied to anatomical information taken from atlases and textbooks. The method uses polygon mesh surfaces to model body contours, the shape of organs as well as their positions, and orientations in the human body. Organ and tissue masses comply with the corresponding data given by the International Commission on Radiological Protection (ICRP) for the 5- and 10-year-old reference children. Bones were segmented into cortical bone, spongiosa, medullary marrow, and cartilage to allow for the use of micro computer tomographic (μCT) images of trabecular bone for skeletal dosimetry. Results: The four phantoms, a male and a female for each age, and their organs are presented in 3D images and their organ and tissue masses in tables which show the compliance of the ICRP reference values. Dosimetric data, calculated for the reference pediatric phantoms by Monte Carlo methods were compared with corresponding data from adult mesh phantoms and pediatric stylized phantoms. The comparisons show reasonable agreement if the anatomical differences between the phantoms are properly taken into account. Conclusions: Pediatric phantoms were developed without using medical images of patients or volunteers for the first time. The models are reference phantoms, suitable for regulatory dosimetry, however, the 3D modeling method can also be applied to medical images to develop patient-specific phantoms.

  17. Graft survival rate of renal transplantation during a period of 10 years in Iran

    Fatemeh Shahbazi

    2015-01-01

    Full Text Available Background: Kidney transplantation is a preferred treatment for many patients with end-stage renal disease (ESRD and is far more profitable than hemodialysis. Analyzing renal transplantation data can help to evaluate the effectiveness of transplantation interventions. The aim of this study was to determine the organ survival rate after kidney transplantation during a period of 10 years (March 2001-March 2011 among transplanted patients in Arak, Markazi Province, Iran. Materials and Methods: In this historical cohort study, all recipients of kidney transplantation from Arak, Markazi Province, Iran who had medical records in Valiasr Hospital and "charity for kidney patients" of Arak, Markazi Province, Iran during a period of 10 years from March 2001 to March 2011 were included. Data collected by using checklists were completed from patients′ hospital records. Kaplan-Meier method was used to determine the graft cumulative survival rate, log-rank test to compare survival curves in subgroups, and Cox regression model to define the hazard ratio and for ruling out the intervening factors. Statistical analysis was conducted by Statistical Package for the Social Sciences (SPSS 20 and Stata 11. Results: Mean duration of follow-up was 55.43 ± 42.02 months. By using the Kaplan-Meier method, the cumulative probability of graft survival at 1, 3, 5, 7, and 10 years was 99.1, 97.7, 94.3, 85.7, and 62.1%, respectively. The number of dialysis by controlling the effect of other variables had a significant association with the risk of graft failure [hazard ratios and 95% confidence interval (CI: 1.47 (1.02-2.13]. Conclusion: This study showed that the graft survival rate was satisfactory in this community and was similar to the results of single-center studies in the world. Dialysis time after transplantation was a significant predictor of survival in the recipients of kidney transplantation that should be considered.

  18. Development of 5- and 10-year-old pediatric phantoms based on polygon mesh surfaces

    Melo Lima, V. J. de; Cassola, V. F.; Kramer, R.; Oliveira Lira, C. A. B. de; Khoury, H. J.; Vieira, J. W. [Department of Anatomy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, CEP 50670-901, Recife, Pernambuco (Brazil); Department of Nuclear Energy, Federal University of Pernambuco, Avenida Professor Luiz Freire 1000, CEP 50740-540, Recife, Pernambuco (Brazil); Federal Institute of Education, Science and Technology of Pernambuco, Avenida Professor Luiz Freire 500, CEP 50740-540, Recife, Pernambuco, Brazil and Polytechnic School of Pernambuco, University of Pernambuco, Rua Benfica 455, CEP 50751-460, Recife, Pernambuco (Brazil)

    2011-08-15

    Purpose: The purpose of this study is the development of reference pediatric phantoms for 5- and 10-year-old children to be used for the calculation of organ and tissue equivalent doses in radiation protection. Methods: The study proposes a method for developing anatomically highly sophisticated pediatric phantoms without using medical images. The 5- and 10-year-old male and female phantoms presented here were developed using 3D modeling software applied to anatomical information taken from atlases and textbooks. The method uses polygon mesh surfaces to model body contours, the shape of organs as well as their positions, and orientations in the human body. Organ and tissue masses comply with the corresponding data given by the International Commission on Radiological Protection (ICRP) for the 5- and 10-year-old reference children. Bones were segmented into cortical bone, spongiosa, medullary marrow, and cartilage to allow for the use of micro computer tomographic ({mu}CT) images of trabecular bone for skeletal dosimetry. Results: The four phantoms, a male and a female for each age, and their organs are presented in 3D images and their organ and tissue masses in tables which show the compliance of the ICRP reference values. Dosimetric data, calculated for the reference pediatric phantoms by Monte Carlo methods were compared with corresponding data from adult mesh phantoms and pediatric stylized phantoms. The comparisons show reasonable agreement if the anatomical differences between the phantoms are properly taken into account. Conclusions: Pediatric phantoms were developed without using medical images of patients or volunteers for the first time. The models are reference phantoms, suitable for regulatory dosimetry, however, the 3D modeling method can also be applied to medical images to develop patient-specific phantoms.

  19. The 10 years of history on the Korea Institute of Nuclear Safety

    This book reports the 10 years of history of Korea Institute of Nuclear Safety which is divided into three part. The first part includes summary, beginning and launching of KINS and establishment and development of KINS. The second deals with inspection safety on nuclear power facilities, protection of radiation and surveillance for environment, safe criterion and development of safe regulation and providing assistance of safe regulation. The third part mentions direction of safe regulation on nuclear power, long term vision and innovation of management, future for KINS. It has appendixes such as a chronological table current condition of budget and human resources.

  20. Looking back, looking forward: 10 years of development to collect, preserve and access the Danish Web

    Laursen, Ditte; Møldrup-Dalum, Per

    Digital heritage archiving is an ongoing activity that requires commitment, involvement and cooperation between heritage institutions and policy makers as well as producers and users of information. In this presentation, we will address how a web archive is created over time as well as what or who...... drives the development of a web archive. Empirically, we will look back on the 10 years of development to collect, preserve and access the Danish web, in the Danish national web archive called Netarkivet. In particular, we will address how a web archive is created and re-created over time in relation to...

  1. [Multicenter retrospective analysis of the patients with sarcoidosis with a 10 year interval in observations].

    Vizel', I Iu; Shmelev, E I; Baranova, O P; Barlamov, P N; Borodina, G L; Denisova, O A; Dobin, V L; Kulbaisov, A M; Kupaev, V I; Listopadova, M V; Ovsiannikov, N V; Os'kin, D N; Petrov, D V; Solov'ev, K I; Shul'zhenko, L V; Vizel', A A

    2014-01-01

    Comparison of the state of 83 patients with histologically confirmed sarcoidosis observed with a 10 year interval revealed remission in 47% of the cases. The main factors having negative effect on prognosis of the disease included extrapulmonary symptoms, the use ofcorticosteroids (at all stages, especially at stage I and in Lofgren syndrome) and antituberculosis drugs, positive TB test. Risk factors of relapses were stage II sarcoidosis, the use of systemic corticosteroids in patients with Lofgren syndrome and antituberculosis drugs, initially low FEV1/FVLC ratio and the number of lymphocytes in peripheral blood. PMID:25799827

  2. Statistics of dose received by occupational personnel from neutron sources - 10 year study

    Personnel Monitoring Section, BARC conducts countrywide fast neutron personnel monitoring using CR-39 solid state nuclear track detector. About 1350 personnel working in a wide range of situations are being monitored presently for fast neutrons. Nearly 50% of the personnel monitored are working with isotopic neutron sources e.g. 241Am-Be (up to 740 GBq source strength) in industry and the remaining are connected with nuclear fuel cycle. This paper describes our experience with this personnel neutron monitor and presents the analysis of the neutron equivalent doses received by personnel working in industry during last 10 years and its contribution as compared to total equivalent dose. (author)

  3. Predictors and longitudinal course of cognitive functioning in schizophrenia spectrum disorders, 10years after baseline

    Bergh, Sara; Hjorthøj, Carsten; Sørensen, Holger J;

    2016-01-01

    illness is another matter of interest. METHODS: Participants from The Danish OPUS Trial, aged 18-45years, with a baseline ICD-10 schizophrenia spectrum diagnosis, were assessed on psychopathology, social and vocational functioning at baseline, and cognitive functioning 5 (N=298) and 10years (N=322) after......BACKGROUND: Identifying baseline predictors of the long-term course of cognitive functioning in schizophrenia spectrum disorders is important because of associations between cognitive functioning (CF) and functional outcome. Determining whether CF remains stable or change during the course of...

  4. Non-traumatic thoracic emergencies: CT diagnosis of acute pulmonary embolism: the first 10 years

    Ghaye, Benoit; Remy, Jacques; Remy-Jardin, Martine [Department of Radiology, Hospital Calmette, University Center of Lille, Blvd Jules Leclerq, 59037 Lille Cedex (France)

    2002-08-01

    Over the past 10 years, spiral CT angiography of the pulmonary arteries has reached a high accuracy in the evaluation of pulmonary embolism. Major advantages of CT compared with ventilation/perfusion lung scintigraphy and pulmonary angiography is direct visualization of clots in the pulmonary arteries, and to provide alternative findings or diagnosis. The recent introduction of multislice CT has improved the evaluation of peripheral pulmonary arteries, enabling high-resolution CT examinations over the entire thorax in a short breathhold. The examination techniques, imaging findings, pitfalls, and results of CT in the diagnosis of pulmonary embolism are reviewed in comparison with other diagnostic tests. (orig.)

  5. Pulmonary alveolar proteinosis in a 10-year-old girl masquerading as tuberculosis.

    Baro, Abhamoni; Shah, Ira; Chandane, Parmarth; Khosla, Indu

    2015-06-01

    Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. Diagnosis is established by bronchoalveolar lavage (BAL), which has macroscopic 'milky appearance', and in the presence of typical computed tomography, findings are diagnostic of PAP but, however, the feature of periodic acid-Schiff-positive eosinophilic proteinaceous fluid raises the confidence of the diagnosis. We report late-onset PAP in a 10-year-old girl who had acid fast bacilli on an initial BAL examination, but was subsequently diagnosed as PAP. PMID:26069841

  6. Detecting Substance Abuse in the Emergency Department: A 10-Year Comparative Study

    Espi Martinez, Fernando; Nieto Munuera, Joaquin; Noguera Velasco, Jose Antonio; Espi Forcen, Fernando

    2013-01-01

    Aims. We have retrospectively analyzed the variations in the clinical profile of patients with a positive consumption of alcohol and/or drugs of abuse that have been confirmed and treated in the Emergency Department of a Virgen de La Arrixaca University Hospital in Murcia (Spain) after a period of 10 years. Secondly, we have assessed if the use of urine toxicology screen tests had any influence on the improvement of the management and/or referral of these patients to specialized services from...

  7. Malignant Nonfunctioning Neuroendocrine Neoplasm of the Pancreas in a 10-Year-Old Child

    Ahmed Marwan

    2009-04-01

    Full Text Available Malignant neoplasms of the pancreas are extremely rare in children and only represent a small percentage of pediatric cancer-related deaths. The paucity of cases reported in the literature, in addition to the lack of understanding of biologic behavior, has led to a lack of consensus concerning optimal management strategy. Presentation differs compared to adult counterparts and generally prognosis is improved even when lymph node metastases occur. Here we review the literature and report the case of a 10-year-old autistic female with a malignant nonfunctioning pancreatic endocrine neoplasm of the head of the pancreas successfully extirpated via pancreaticoduodenectomy.

  8. Physical activity patterns during school recess : a study in children 6 to 10 years old

    Lopes, Vítor P.; Vasques, Catarina; Pereira, Beatriz; Maia, José A. R.; Malina, Robert M.

    2006-01-01

    The aims of this study were to characterize the spontaneous physical activity of children during school recess, and to estimate variation in physical activity associated with gender and age. A MTI actigraph (Model 7164) was used with a sample of 140 boys and 131 girls, 6 to 10 years of age. MTI counts were converted to METs using a regression equation developed for children. The number and average duration of periods of activity by intensity were calculated for each child during a 30 minute r...

  9. Prevalence of Generalised Joint Hypermobility, Artralgia and Motor Competence in 10-year old school children

    Remvig, Lars; Kümmel, Christina; Halkjær-Kristensen, Jens;

    2011-01-01

    prevalence of GJH and of benign joint hypermobility syndrome (BJHS) in 10-year-old children, (2) compare children with and without GJH and BJHS regarding motor competence, physical activity, and musculoskeletal pain and injuries. Subjects and methods: All fourth-grade children in a Copenhagen municipality......Objectives: Diverging results exist for children regarding the relation between generalized joint hypermobility (GJH) and musculoskeletal complaints, as well as relations between GJH and insufficient motor development, and/or reduced physical activity level. The main purposes were to (1) survey the...

  10. Prevalence of red-green color vision deficiency (cvd) among science students: a 10 years' survey

    Arun V. Panat , M.Sc. M.Phil.; Dilip A. Kulkarni M.S.(G.Surgeon)

    2016-01-01

    Red-green Color vision deficiency (CVD) has a high prevalence and is often a handicap in everyday life. The fact that most of the students do not know they have CVD due to non testing of color vision. All Science faculty students of the ASC Rahuri College in the age range of 17-19 were screened for Red-green CVD by using Ishihara test plates from 2001 to 2010. Thus total 654 males and 292 female students were screened during 10 years. The collected data were analyzed for frequency estimation ...

  11. Development of 5 and 10 years old infant phantoms based on polygonal meshes

    This paper focuses the development of reference infant phantoms of 5 and 10 years old to be used in calculation of equivalent doses in the area of radiological protection. The method uses tools developed for the modelling of 3D objects. The forms and positions are available in the literature. The mass values of each organ and tissue were adjusted according to the reference data published by the International Commission Radiological Protection. The results are presented in image of organs and tissues, and in tables. Dosimetric calculations show concordance with adult and infant phantoms, considering the differences among phantoms

  12. The ASN considers the Fessenheim-1 reactor able to operate 10 years more

    On July 4., 2011 the Authority of Nuclear Safety (ASN) allowed the unit 1 of the Fessenheim plant to operate 10 years more under 2 major conditions. First the reinforcement of the foundation mat in order to improve the reactor resistance to corium and secondly the installation of an emergency system for the evacuation of the residual heat in case of the loss of the heat sink. The ASN stresses that this decision does not take into account the conclusions (expected at the end of 2011) of the complementary safety assessment (ECS) that was launched following the Fukushima accident. (A.C.)

  13. Population-based study of acquired cerebellar ataxia in Al-Kharga district, New Valley, Egypt

    Farghaly WMA; El-Tallawy HN; Shehata GA; Rageh TA; Abdel Hakeem N; Abo-Elfetoh NM

    2011-01-01

    Wafaa MA Farghaly1, Hamdy N El-Tallawy1, Ghaydaa A Shehata1, Tarek A Rageh1, Nabil Abdel Hakeem2, Noha M Abo-Elfetoh11Department of Neurology and Psychiatry, Assiut University, Assiut, Egypt; 2Al Azhar University, Assiut Branch, EgyptBackground: The aim of this research was to determine the prevalence and etiology of acquired ataxia in Al-Kharga district, New Valley, Egypt.Methods: A population-based study of acquired ataxia was conducted in a defined geographical region with a total populati...

  14. A Population-Based Clinical Trial of Irinotecan and Carboplatin

    Derick Lau

    2009-01-01

    Full Text Available Purpose. Phase I trials of anticancer drugs are commonly conducted using the method of modified Fibonacci. We have developed a population-based design for phase I trials of combining anticancer drugs such as irinotecan and carboplatin. Patients and Methods. Intrapatient dose escalation of irinotecan and carboplatin was performed according to a predetermined schema to reach individual dose-limiting toxicity (DLT in 50 patients with solid tumors refractory to previous chemotherapy. The individual toxicity-limiting dose levels were analyzed for normal distribution using the method of Ryan-Joiner and subsequently used to determine a population-based maximum tolerated dose (pMTD. For comparison, a simulation study was performed using the method of modified Fibonacci. Results. The most common dose-limiting toxicities (DLTs included neutropenia (58%, thrombocytopenia (16%, and diarrhea (8%. The frequency of individual toxicity-limiting dose levels of 50 patients approximated a normal distribution. The dose levels associated with individual limiting toxicities ranged from level 1 (irinotecan 100 mg/m2 and carboplatin AUC = 4 mg/mL x min to level 8 (irinotecan 350 mg/m2 and carboplatin AUC = 6. The pMTD was determined to be dose level 3 (150 mg/m2 for irinotecan and AUC = 5 for carboplatin. In contrast, the MTD was determined to be dose level 4 (200 mg/m2 for irinotecan and AUC 5 for carboplatin by modified-Fibonacci simulation. Conclusions. The population-based design of phase I trial allows optimization of dose intensity and derivation of a pMTD. The pMTD has been applied in phase II trial of irinotecan and carboplatin in patients with small-cell lung cancer.

  15. Post-Test Analysis of a 10-Year Sodium Heat Pipe Life Test

    Rosenfeld, John H.; Locci, Ivan E.; Sanzi, James L.; Hull, David R.; Geng, Steven M.

    2011-01-01

    High-temperature heat pipes are being evaluated for use in energy conversion applications such as fuel cells, gas turbine re-combustors, Stirling cycle heat sources; and with the resurgence of space nuclear power both as reactor heat removal elements and as radiator elements. Long operating life and reliable performance are critical requirements for these applications. Accordingly, long-term materials compatibility is being evaluated through the use of high-temperature life test heat pipes. Thermacore, Inc., has carried out a sodium heat pipe 10-year life test to establish long-term operating reliability. Sodium heat pipes have demonstrated favorable materials compatibility and heat transport characteristics at high operating temperatures in air over long time periods. A representative one-tenth segment Stirling Space Power Converter heat pipe with an Inconel 718 envelope and a stainless steel screen wick has operated for over 87,000 hr (10 years) at nearly 700 C. These life test results have demonstrated the potential for high-temperature heat pipes to serve as reliable energy conversion system components for power applications that require long operating lifetime with high reliability. Detailed design specifications, operating history, and post-test analysis of the heat pipe and sodium working fluid are described. Lessons learned and future life test plans are also discussed.

  16. Performance of concrete after 10 years of exposure in the Arctic marine environment

    Zhang, M.H. [National University of Singapore (Singapore); Bilodeau, A.; Malhotra, V.M. [Natural Resources Canada, Ottawa, ON (Canada)

    2001-07-01

    A study was conducted to test the service life of concrete that has been exposed to an Arctic marine environment for 10 years. A total of 12 concrete panels were installed at a site at Nanisivik, Baffin Island, Northwest Territories, Canada. Six of the panels were made with normal-weight aggregate concrete, the others with concrete mixed with expanded shale lightweight aggregate. Steel fibres were also in the cement and the portland cement was replaced with fly ash, slag, silica fume or a combination of fly ash and silica fume. The panels were then visually inspected and cores were also taken to determine the chloride content at various depths from the exposure surface. It was shown that after 10 years of exposure, the panel made of normal weight aggregate did not show much loss of mass from ice abrasion. However, panels made with lightweight aggregate showed mass loss, particularly on the surfaces exposed to the tidal zone. Less damage and cracking was observed in the steel fibre-reinforced panels. Mixtures with fly ash, slag or silica fume showed better resistance to chloride penetration. The use of normal weight limestone aggregate or expanded shale lightweight aggregate did not make a difference in the resistance of the concrete to chloride-ion penetration for non-fibre-reinforced portland cement concrete, but a difference was noted for fibre-reinforced portland cement concrete. Those made with lightweight aggregate materials exhibited a lower chloride-ion content. 7 refs., 10 tabs., 19 figs.

  17. Change in physical mobility over 10 years in post-polio syndrome.

    Bickerstaffe, A; Beelen, A; Nollet, F

    2015-03-01

    Post-polio syndrome is characterised by progressive muscle weakness and other symptoms which can limit physical mobility. We assessed the rate of decline in mobility over 10 years in relation to strength decline; and investigated potential predictors for the rate of decline of walking capacity, a measure of mobility, in 48 patients with post-polio syndrome and proven quadriceps dysfunction at baseline. Average walking capacity and self-reported physical mobility declined over 10 years, by 6 and 14%, respectively. Concomitantly people lost an average of 15% of isometric quadriceps strength. Significantly more people used walking aids offering greater support at follow-up. Notably, there was much individual variation, with 18% of participants losing a substantial amount of walking capacity (27% decline) and concomitant self-reported physical mobility (38% decline). Loss of quadriceps strength only explained a small proportion of the variance of the decline in walking capacity (R = 11%) and the rate of decline could not be predicted from baseline values for strength, walking capacity, self-reported physical mobility or basic demographics. The individual variability, yet lack of predictive factors, underscores the need for personally tailored care based on actual functional decline in patients with post-polio syndrome. PMID:25613808

  18. A 10-year performance trajectory of top nutrition journals′ impact factors

    Narges Jani

    2012-01-01

    Full Text Available Background and Aim: This study was performed to evaluate the impact factors (IFs and total citations of ISI-indexed nutrition journals in a 10-year period from 1999 to 2008 in order to assess the quality of nutrition journals. Materials and Methods: For this retrospective study, the IF and total citation data from 1998 to 2008 were collected through Journal Citation Reports of Thomson Scientific Corporation Web of Knowledge. We selected five highly cited journals in the "nutrition and dietetics" category for our analysis. These journals include Annual Reviews in Nutrition (ANNU REV NUTR, American Journal of Clinical Nutrition (AJCN, Progress in Lipid Research (PROG LIPID RES, Journal of Nutrition (J NUTR, and International Journal of Obesity (INT J OBESITY Results: All five selected journals were ranked as one of the top ten "nutrition and dietetics" journals between 1999 and 2008 in ISI database. Most of selected journals′ IF had an upward trend during the 10-year period with fluctuation in some cases. AJCN consistently received the greatest number of total citations during the study period, although its IF was not the highest among the five journals studied. Conclusion: The IF illustrated changes in relative rankings of five highly cited journals included in the "nutrition and dietetics" category of the Web of Knowledge. Rank according to the absolute number of citations received, however, did not correlate with rank according to IF.

  19. Taiwan’s biodiversity research achievements over the past 10 years (2001–2011

    Kwang-Tsao Shao

    2012-09-01

    Full Text Available Since the 1990s, Taiwan’s academic community has been promoting the conservation, education, and research of biodiversity. The Administration authority passed the “Biodiversity Promotion Plan” in 2001 and the Research Agency established an independent Biodiversity discipline in 2002. Subsequently, several universities and the Academia Sinica either founded or reorganized biodiversity research institutes or centers to actively carry out related research. The Research Agency sponsors basic scientific studies, whereas the Agriculture Agency focuses on direct applications, including conservation, management, and utilization of natural resources. This article reviews Taiwan’s research achievements over the past 10 years by summarizing the contents in the “DIVERSITAS” chapter in the book of “Taiwan Global Change Research” (published in 2009. The excerpt covers taxonomy, long-term ecological studies, ecosystem modeling, climate change, phylogeography, genetic resources, habitat restoration, and database construction. We report the trends in publication year, discipline, habitat type, and study organism of all SCI (Science Citation Index papers published from Taiwan in the past 10 years to gauge the capacity and progress of biodiversity research in Taiwan. Lastly, we report the problems and prospects of Taiwan’s future biodiversity research.

  20. Tracking of a dietary pattern and its components over 10-years in the severely obese.

    David J Johns

    Full Text Available Understanding how dietary intake changes over time is important for studies of diet and disease and may inform interventions to improve dietary intakes. We investigated how a dietary pattern (DP tracked over 10-years in the Swedish Obese Subjects (SOS study control group. Dietary intake was assessed at multiple time-points in 2037 severely obese individuals (BMI 41 ± 4 kg/m(2. Reduced rank regression was used to derive a dietary pattern using dietary energy density (kJ/g, saturated fat (% and fibre density (mg/kJ as response variables and score respondents at each follow-up. Tracking coefficients for the DP, its key foods and macronutrient response variables and corrected for time-dependent and time-independent covariates were calculated using generalised estimating equations to take into account all available data. The DP tracking coefficient was moderate for women (0.40; 95% CI: 0.38-0.42 and men (0.38; 95% CI: 0.35-0.41. Of the eleven foods key to this DP, fruit and vegetable intakes had the strongest tracking coefficient for both sexes. Fast food and candy had the lowest tracking coefficients for women and men respectively. Scores for an energy dense, high saturated fat, low fibre density DP appear moderately stable over a 10-year period in this severely obese population. Furthermore, some food groups appear more amenable to change while others, often the most healthful, appear more stable and may require intervention before adulthood.

  1. Relationship Between Somatotype and PHV in Iranian 7-10 Years Old Boys

    Amir Hossein Barati

    2013-02-01

    Full Text Available Introduction: An important variable in investigation of agility during puberty is the age of reaching peak high velocity, which like other agility indicators is under the effect of different factors such as physical condition and type. The purpose of present research was to examine relationship between somatotype and peak high velocity (PHV among Iranian 7-10 years old boys. Methods: Participants were 313 7-10 year-old members of Basij talent identification centers in all Iran's provinces. Somatotype data were calculated using Heath-Cartr instruction and PHV was measured using Mirwald formula and were analyzed using Pearson correlation and multiple regressions. Results: Results of pearson correlation showed that PHV had a positive correlation with ectomorphy and negative correlation with endomrphy and mesomorphy. Total correlation between PHV and somatotype was 0.50 which explained 25% of PHV variance. Results of regression analysis showed ectomrphy and endomorphy were significant predictors of PHV but msomrphy was not a significant predictor of PHV. Conclusion: Endomorphy had a smaller part in predicting the PHV age, but mesomorphy was not a strong predictor, Moreover, ectomorphy following endomrophy had a strong predicting power. Studies in this area suggest that those who have greater ectomorphic characteristics are less agile and the physiologic requisites for their puberty develop later in their bodies. Therefore poor sport performance of ectomorphic children may result from their distance to PHV age so coaches and instructors should consider this measurement and somatotype.

  2. Changes in Pulmonary Function Up to 10 Years After Locoregional Breast Irradiation

    Purpose: To evaluate the long-term impact of locoregional breast radiotherapy (RT) on pulmonary function tests (PFTs). Methods and Materials: This study included 75 women who underwent postoperative locoregional breast RT. PFTs were performed before RT and 3, 6, and 12 months and 8 to 10 years after RT. By use of univariate and multivariate analyses, the impact of treatment- and patient-related factors on late changes in PFTs was evaluated. Results: During the first year after RT, all PFTs significantly worsened at 3 to 6 months after RT (p 1) recovered almost to baseline values, whereas total lung capacity (TLC) and diffusion capacity of carbon monoxide (DLCO) recovered only slightly and were still found to be decreased compared with baseline (p 1 of 4% (p = 0.03) and in VC, DLCO, and TLC of 5%, 9%, and 11% (all p 1 (p = 0.027). For FEV1 and DLCO, an early decrease was predictive for a late decrease (p = 0.003 and p = 0.0009, respectively). Conclusions: The time course of PFT changes after locoregional RT for breast cancer follows a biphasic pattern. An early reduction in PFTs at 3 to 6 months with a partial recovery at 12 months after RT is followed by a late, more important PFT reduction up to 8 to 10 years after RT. Tamoxifen use may have an impact on this late decline in PFTs.

  3. [Food avoidance emotional disorder in 3 to 10-year-old children: a clinical reality].

    Goëb, J-L; Azcona, B; Troussier, F; Malka, J; Giniès, J-L; Duverger, P

    2005-09-01

    We underline the clinical importance of a specific eating disorder in 3 to 10 years old children, when the majority of the works about the prepubertal eating disorders focus either on the period just preceding adolescence (often between 10 and 13 years), or on the second half of the first year of the baby. Within the eating disorders described in the literature, we compare the clinical presentation of most of these 3 to 10 years old children with the food avoidance emotional disorder described during adolescence. These problems of eating behaviour (various selective eating with or without provoked vomiting) are ignored for a long time in these young children because of quite a satisfactory growth, but these children are often seen in emergency rooms because of a brutally complete eating refusal. Therapeutic consultations allow these children to express their fears about diseases, poisoning and death, for themselves or for their close relations, in particular the mother, without endangering their body. The early recognition and care of these difficulties of conciliation between the body and the thoughts impose a narrow collaboration between paediatric and psychiatric staffs. PMID:15979861

  4. Trends and predictors of asthma costs: results from a 10-year longitudinal study.

    Tan, Ngiap Chuan; Nguyen, Hai V; Lye, Weng Kit; Sankari, Usha; Nadkarni, Nivedita V

    2016-03-01

    Research on asthma costs often focuses on estimating average asthma costs. Trends in asthma costs and patterns of medication use, especially for those who have been followed up and under treatment, have received much less attention. This study's objective was to document asthma costs over time for asthma patients who are enrolled in an asthma care programme in Singapore and to identify its predictors, using a 10-year longitudinal dataset.The study population comprised different cohorts of 939 asthma patients entering the programme at different times during 2004-2013. Average asthma costs were estimated and the trends over time examined graphically, within and across patient cohorts. Regression analyses were conducted to examine cost predictors, with a focus on the relationship between risk factors at programme enrolment and subsequent asthma costs.The results indicate that 10-year average annual asthma cost was GBP 341 per patient. The main drivers of costs were asthma medications and consultation fees. Use of combined inhaled corticosteroid/long-acting β-agonist medications increased over time, but this was accompanied by declines in controller drug use, doctor visits and total asthma drug costs. Obesity, smoking and asthma severity were the main predictors of subsequent asthma costs, especially for females. PMID:26647437

  5. Highlights from 10 Years of NASA/KNMI/FMI Collaboration on UV Remote Sensing from Space

    Bhartia, Pawan K.

    2010-01-01

    The first joint meeting between NASA, KNMI and FMI scientists was held on 13 & 14 June, 2000, almost exactly 10 years ago. NASA had recently selected 14 US scientists to work on instrument calibration, science algorithms, and validation activities related to the Ozone Monitoring Instrument (OMI) that we being built by collaboration between the Netherlands and Finland for flight on NASA's EOS Aura satellite. The progress on this project had been remarkable for a space based instrument. Only two years before this meeting my colleague Ernest Hilsenrath and I had visited Netherlands at the invitation of Fokker Space to persuade KNMI management to collaborate with NASA on this mission. And only 4 years after the first science meeting was held OMI was lunched on the Aura spacecraft. Next month will be the 6 th anniversary of this launch and very successful operation of OMI. All this was possible because of the leadership from Dr. Hennie Kelder and KNMI management who in 1998 saw the opportunity for Netherlands in the mission and stepped up to the challenge by creating a young and talented team of scientists at KNMI under the leadership of Dr. Pieterenel Levelt. This vision has now put Netherlands as the leading country in the world in monitoring air quality from space. Recent selection of TROPOMI by ESA attests to the success of this vision. I will present some selected highlights of our very successful collaboration on this project over the past 10 years.

  6. 10 Years of Height Resolved, Cloud-Track, Vector Winds from MISR

    Garay, M. J.; Mueller, K. J.; Moroney, C. M.; Jovanovic, V.; Wu, D. L.; Diner, D. J.

    2009-12-01

    By utilizing multiple camera views and fast image matching algorithms to identify common features and determine feature motion, the MISR instrument on NASA’s Terra satellite has now collected nearly 10 years of height-resolved, cloud-track, vector winds using a single, globally consistent algorithm. The MISR cloud-track winds are reported globally on mesoscale domains of 70.4 km × 70.4 km and referenced to stereoscopically derived heights above the earth ellipsoid, which have a nominal vertical resolution of approximately 500 m. Importantly, from the standpoint of climate research, the stereo height assignment and wind retrieval are largely insensitive to instrument calibration changes because the pattern matcher relies only on relative brightness values, rather than the absolute magnitude of the brightness. We will describe comparisons with other wind datasets, including geostationary cloud drift winds, scatterometer surface winds, and reanalysis model winds, that demonstrate the quality of the MISR winds. We will also show the coverage and resolution advantages that MISR provides relative to these other datasets. Additionally, because the global winds are driven primarily by the global (im)balance of heating, monitoring variations in the winds over 10 years promises to yield important insights into the processes related to the hydrologic cycle and transport of heat and water vapor, such as the Madden-Julian Oscillation (MJO) and the El Niño Southern Oscillation (ENSO).

  7. Comparison of methodologies for TMY generation using 10 years data for Damascus, Syria

    The generation of a typical meteorological year (TMY) is of great importance for calculations concerning many applications in the field of thermal engineering. The need of an accurate TMY for simulations has been well recognized over the years. Various methods for deriving TMYs have been developed, but their final results can be significantly different. In this paper, the major methodologies reported in the literature were applied to 10 year hourly measurements of weather data from Damascus, Syria. The TMYs obtained were evaluated according to their impact on the typical Syrian building's thermal system in order to decide which method should be recommended for generating typical meteorological years and for predicting the performance of thermal systems in buildings. Based on simulation results for seasonally, monthly and daily building thermal loads, three widely used statistical estimators, namely, root mean square difference RMSD, total standard error SEE and chi square χ 2 were calculated to assess the performance of each TMY. The findings showed that the TMY giving the closest performance to the average performance of the building's thermal system as predicted using the 10 year weather data is the one generated by using the modified Sandia method. This method gives sufficiently accurate results compared with the other methods reported in the literature

  8. Eating Behavior and Childhood Overweight Among Population-Based Elementary Schoolchildren in Japan

    Akatsuki Kokaze

    2012-04-01

    Full Text Available This study investigated the relationship between eating behavior and childhood overweight among population-based elementary schoolchildren in Japan. Data was collected from fourth graders (9 or 10 years of age from Ina Town, Saitama Prefecture, Japan from 1999 to 2009. Information about subjects’ sex, age, and lifestyle, including eating behaviors (eating until full and chewing thoroughly, was obtained using a self-administered questionnaire, and height and weight were measured directly. Overweight was determined according to the definition established by the International Obesity Task Force. Data from 4027 subjects (2079 boys and 1948 girls were analyzed. Chewing thoroughly was associated with a significantly decreased odds ratio (OR for being overweight, whereas eating until full significantly increased the OR for being overweight (OR: 1.50, 95% confidence interval: 1.16–1.94 among boys. However, eating until full was not associated with a significantly increased OR for being overweight among the group that reported chewing thoroughly, whereas it was associated with a significantly increased OR for being overweight (2.02, 1.38–2.94 among boys who did not chew thoroughly. In conclusion, eating until full or not chewing thoroughly was associated with being overweight among elementary schoolchildren. Results of this study suggest that chewing thoroughly may be an avenue to explore childhood overweight prevention efforts.

  9. Incidence of zoonotic Salmonella species bacteraemia: a multi-national population-based study

    Laupland, Kevin; Schønheyder, Henrik Carl; Lyytikäinen, Outi;

    2009-01-01

    Objectives: Although zoonotic (non-typhoidal) Salmonella species are important causes of invasive infections worldwide, few studies have investigated their epidemiology at the population level. The objective of this study was to define the incidence of zoonotic Salmonella species bacteraemia...... in a large multi-national population and to evaluate temporal and regional differences. Methods: Population-based laboratory surveillance for all zoonotic Salmonella species bacteraemias was conducted in five regions (Finland, Canberra, Australia, North Jutland Region, Denmark, and Calgary and Sherbrooke......, Canada; combined population 7.5 million residents annually) during 2000-2007. Results: A total of 480 zoonotic Salmonella species bacteraemias were identified for an overall annual incidence of 8.1 per million population. The incidence was lowest in the spring and highest in the summer, and progressively...

  10. Prognostic factors in glioblastoma multiforme. 10 years experience of a single institution

    Background: To analyze prognostic factors in patients with a glioblastoma multiforme treated in an academic institute over the last 10 years. Patients and method: From 1988 to 1998, 198 patients with pathologically confirmed glioblastoma multiforme were analyzed. Five radiation schedules were used mainly based on pretreatment selection criteria: 1. 60 Gy in 30 fractions followed by an interstitial iridium-192 (Ir-192) boost for selected patients with a good performance and a small circumscribed tumor, 2. 66 Gy in 33 fractions for good performance patients, 3. 40 Gy in eight fractions or 4. 28 Gy in four fractions for poor prognostic patients and 5. no irradiation. Results: Median survival was 16 months, 7 months, 5.6 months, 6.6 months and 1.8 months for the groups treated with Ir-192, 66 Gy, 40 Gy, 28 Gy and the group without treatment, respectively. No significant improvement in survival was encountered over the last 10 years. At multivariate analysis patients treated with a hypofractionated scheme showed a similar survival probability and duration of palliative effect compared to the conventionally fractionated group. The poor prognostic groups receiving radiotherapy had a highly significant better survival compared to the no-treatment group. Patients treated with an Ir-192 boost had a better median survival compared to a historical group matched on selection criteria but without boost treatment (16 vs 9.7 months, n.s.). However, survival at 2 years was similar. Analysis on pretreatment characteristics at multivariate analysis revealed age, neurological performance, addition of radiotherapy, total resection, tumor size post surgery and deterioration before start of radiotherapy (borderline) as significant prognostic factors for survival. Conclusion: Despite technical developments in surgery and radiotherapy over the last 10 years, survival of patients with a glioblastoma multiforme has not improved in our institution. The analysis of prognostic factors

  11. Etude Climat no. 37 '10 lessons from 10 years of the CDM'

    Among the publications of CDC Climat Research, 'Climate Reports' offer in-depth analyses on a given subject. This issue addresses the following points: The Clean Development Mechanism (CDM) is the first and by far the largest carbon offset instrument in the world. To date, it is the only market based on an environmental commodity which managed to attract several billions of euros of private capital on an annual basis. Being the first-of-a-kind climate change mitigation instrument, the CDM followed a 'learning by doing' pattern undergoing numerous reforms throughout its more than 10-year history. Although the post-2012 fate of the mechanism remains uncertain, one should not 'throw out the baby with the bath water' as the lessons from the CDM experience may be useful not only for the CDM reform but also for new market instruments

  12. From Exotic to Mainstream: A 10-year Odyssey from Internet Speed to Boundary Spanning with Scrum

    Baskerville, Richard; Pries-Heje, Jan; Madsen, Sabine

    Based on four empirical studies conducted over a 10-year time period from 1999 to 2008 we investigate how local software processes interact with global changes in the software development context. In 1999 companies were developing software at high speed in a desperate rush to be first-to-market. In 2001 a new high speed/quick results development process had become established practice. In 2003 changes in the market created the need for a more balanced view on speed and quality, and in 2008 companies were successfully combining agile and plan driven approaches to achieve the benefits of both. The studies reveal a twostage pattern in which dramatic changes in the market causes disruption of established practices, experimentation, and process adaptations followed by consolidation of lessons learnt into a new (and once again mature) software development process. Limitations, implications, and areas for future research are discussed.

  13. Emergency Peripartum Hysterectomies at a District General Hospital in United Kingdom: 10-Year Review of Practice

    J. Chester

    2016-01-01

    Full Text Available Peripartum haemorrhage is an obstetric emergency which requires effective and timely management. A retrospective analysis was conducted at a single centre district hospital, over a 10-year period to describe factors that would lead to a peripartum hysterectomy. We sought to establish intraoperative and postoperative risks and review outcomes and complications associated with the procedure. A total of 29 cases (incidence 0.8 per 1000 were reviewed over 2001–2011. The mean parity was 1.8 and the mean maternal age was 33 years. Uterine atony was the most common indication for hysterectomy (12/29 followed by placenta praevia and accreta (4/29 and 5/29 cases, resp.. The commonest postoperative complications were sepsis and paralytic ileus. EPH most commonly occurs due to uterine atony but remains difficult to predict. Hospitals should continue to have robust systems and the necessary resources available to perform EPH where clinically indicated.

  14. A review of Internet pornography use research: methodology and content from the past 10 years.

    Short, Mary B; Black, Lora; Smith, Angela H; Wetterneck, Chad T; Wells, Daryl E

    2012-01-01

    Internet pornography (IP) use has increased over the past 10 years. The effects of IP use are widespread and are both negative (e.g., relationship and interpersonal distress) and positive (e.g., increases in sexual knowledge and attitudes toward sex). Given the possible negative effects of IP use, understanding the definition of IP, the types of IP used, and reasons for IP use is important. The present study reviews the methodology and content of available literature regarding IP use in nondeviant adult populations. The study seeks to determine how the studies defined IP, utilized validated measures of pornography use, examined variables related to IP, and addressed form and function of IP use. Overall, studies were inconsistent in their definitions of IP, measurement, and their assessment of the form and function of IP use. Discussion regarding how methodological differences between studies may impact the results and the ability to generalize findings is provided, and suggestions for future studies are offered. PMID:22032795

  15. Comorbid personality disorder predicts suicide after major depression: a 10-year follow-up

    Hansen, P E B; Wang, A G; Stage, K B;

    2003-01-01

    followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. RESULTS: The suicide rate for non-melancholic depressed patients was......OBJECTIVE: To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. METHOD: A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were...... significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15-10.10)]. CONCLUSION: The study indicates that the non-melancholic aspect of depression, and especially comorbid personality...

  16. Features of the psycho-physiological status of boys in 9-10 years.

    Romanenko V.A.

    2012-08-01

    Full Text Available The problems of diagnosis of psycho-physiological status of boys in the prepubertal stage of their biological development is considered. The study involved 94 boys aged 9-10 years. They were assessed by parameters of physical development, the functional state of the nervous, cardio-respiratory, muscular and sensory systems and motor fitness, energy and properties of psychodynamics. It is shown that the failure of the approach to assess children's physical health on the grounds of their physical development. Children of this age are characterized by a lag in terms of static lung volume, and vice versa - ahead of age norms in the development of pulmonary ventilation function and resistance to hypoxia. Central hemodynamic parameters vary within age norms. From the observed dominance of neurodynamic mechanisms of excitation and response of advanced type. The established features of the psycho-physiological status, can be used as prognostic indicators in guiding children to sports activities.

  17. Tibial nerve intraneural ganglion cyst in a 10-year-old boy

    Squires, Judy H. [University of Cincinnati College of Medicine, Department of Radiology, Cincinnati, OH (United States); Emery, Kathleen H.; Johnson, Neil [Cincinnati Children' s Hospital Medical Center, Division of Radiology, Cincinnati, OH (United States); Sorger, Joel [Cincinnati Children' s Hospital Medical Center, Division of Orthopedics, Cincinnati, OH (United States)

    2014-04-15

    Intraneural ganglion cysts are uncommon cystic lesions of peripheral nerves that are typically encountered in adults. In the lower extremity, the peroneal nerve is most frequently affected with involvement of the tibial nerve much less common. This article describes a tibial intraneural ganglion cyst in a 10-year-old boy. Although extremely rare, intraneural ganglion cysts of the tibial nerve should be considered when a nonenhancing cystic structure with intra-articular extension is identified along the course of the nerve. This report also details the unsuccessful attempt at percutaneous treatment with US-guided cyst aspiration and steroid injection, an option recently reported as a viable alternative to open surgical resection. (orig.)

  18. Heterogeneity in 10-Year Course Trajectories of Moderate to Severe Major Depressive Disorder

    Musliner, Katherine L; Munk-Olsen, Trine; Laursen, Thomas M; Eaton, William W; Zandi, Peter P; Mortensen, Preben B

    2016-01-01

    moderate to severe MDD. Objective: To characterize patterns and correlates of 10-year course trajectories of MDD in the DPCRR. Design, Setting, and Participants: A cohort containing 11 640 individuals born in Denmark in 1955 or later with their first recorded MDD diagnosis in the DPCRR between 1995 and......) aged 18 to 48 years (mean [SD], 31.4 [7.3]) at their first recorded MDD diagnosis. Four trajectory classes were identified: brief contact (77.0%) (characterized by probability of contact after 2 years); prolonged initial contact (12.8%) (characterized by high decreasing probability of contact during...... the first 5 years); later reentry (7.1%) (characterized by moderate probability of contact during the second 5 years); and persistent contact (3.1%) (characterized by high or moderate probability of contact throughout). Female sex (odds ratio [OR] range, 1.82-2.22), inpatient treatment (OR range, 1...

  19. Comorbid personality disorder predicts suicide after major depression: a 10-year follow-up

    Hansen, P E B; Wang, A G; Stage, K B; Kragh-Sorensen, P

    2003-01-01

    OBJECTIVE: To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. METHOD: A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were...... followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. RESULTS: The suicide rate for non-melancholic depressed patients was...... significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15-10.10)]. CONCLUSION: The study indicates that the non-melancholic aspect of depression, and especially comorbid personality...

  20. Vogt-Koyanagi-Harada Syndrome in a 10 Years Old Child.

    Aalia R Sufi

    2011-07-01

    Full Text Available The Vogt-Koyanagi-Harada (VKH syndrome is a rare systemic disorder of uveitis, dysacousia, vitiligo, premature graying of the hair, eyebrows and eyelashes, and meningoencephalitis. Although frequently unrecognised,VKH may affect children. We report a case of a 10 year old girl who presented with headache and dimness of vision and was diagnosed as papillitis on the basis of bilateral disc edema. However over the course of time developed skin changes (poliosis, vitiligo over lower back and depigmented patches in inferior fundus suggesting diagnosis of VKH disease. Thus the diagnosis is difficult in the absence of extraocular manifestations. In such cases the diagnosis is based on clinical evolution of the disease.

  1. Intercostal myositis ossificans misdiagnosed as osteosarcoma in a 10-year-old child

    Koob, Meriam; Durckel, Jean; Dosch, Jean-Claude; Dietemann, Jean-Louis [Hopital de Hautepierre, Service de Radiologie II, Hopitaux Universitaires, Strasbourg Cedex (France); Entz-Werle, Natacha [Hopitaux Universitaires, Hopital de Hautepierre, Service d' Onco-hematologie pediatrique, Strasbourg Cedex (France)

    2010-12-15

    Myositis ossificans (MO) is a rare benign cause of heterotopic bone formation within soft tissue. It most commonly affects adolescents and young adults, typically in the limbs and following trauma. Very few cases have been reported in children. We report here a case of nontraumatic MO occurring in a 10-year-old girl with an uncommon location in the 5th right intercostal space; it was initially misdiagnosed and treated as osteosarcoma. Imaging findings including plain radiographs, CT, MRI, bone scintigraphy and PET-CT are described. This case highlights the central role played by imaging in diagnosis, thus avoiding biopsy that can erroneously suggest osteosarcoma as the diagnosis, as occurred in this case. (orig.)

  2. Overview of humanistic progress in sickle cell anemia during the past 10 years.

    Nash, K B

    1983-01-01

    Humanistic progress in sickle cell anemia over the past 10 years is described, with a focus on individual, institutional, and societal progress. Accessibility, acceptability, and accountability are examined for humanistic progress in medical care, counseling, education, support services, and public education. Specific dimensions of humanistic progress are noted, including career development, work with schools and employers, establishment of tutorial programs, retraining of health care providers, utilization of the team concept, and increasing awareness of this disease. Constraints, such as funding patterns and the political climate, will be considered as part of the challenge for the next decade. A frame of reference is suggested for meeting the challenges ahead for further humanistic progress. PMID:6670715

  3. Spinal dysraphism. A study of patients over the age of 10 years.

    Yamane, T; Shinoto, A; Kamegaya, M; Shinada, Y

    1991-11-01

    Thirty patients over the age of 10 years, exhibiting cutaneous manifestations on the back suspected to be due to spinal dysraphism, and neurologic deficits, were studied to analyze neurologic appearance. Neurologic deficits appeared by age 5 in 26 patients. No patient complained of low-back pain or sciatica. Paralytic deformities of the lower extremities were divided into four grades for evaluation: A = no deformity, with only urinary disturbance (four cases); B = toe-limited deformity (two cases); C = toe and foot-limited deformity (six cases); D = toe, foot, ankle, and lower limb deformity (18 cases). Patients with slight neurologic disturbance, either Grade A or without urinary disturbance, were seen among the patients who had undergone a release operation by age 2, although neurologic appearance in patients in severe grades was not related to the age at release operation. Also, the release operation was thought to be effective in preventing low-back pain or sciatica. PMID:1750003

  4. Acute Cholangitis following Intraductal Migration of Surgical Clips 10 Years after Laparoscopic Cholecystectomy

    Natalie E. Cookson

    2015-01-01

    Full Text Available Background. Laparoscopic cholecystectomy represents the gold standard approach for treatment of symptomatic gallstones. Surgery-associated complications include bleeding, bile duct injury, and retained stones. Migration of surgical clips after cholecystectomy is a rare complication and may result in gallstone formation “clip cholelithiasis”. Case Report. We report a case of a 55-year-old female patient who presented with right upper quadrant pain and severe sepsis having undergone an uncomplicated laparoscopic cholecystectomy 10 years earlier. Computed tomography (CT imaging revealed hyperdense material in the common bile duct (CBD compatible with retained calculus. Endoscopic retrograde cholangiopancreatography (ERCP revealed appearances in keeping with a migrated surgical clip within the CBD. Balloon trawl successfully extracted this, alleviating the patient’s jaundice and sepsis. Conclusion. Intraductal clip migration is a rarely encountered complication after laparoscopic cholecystectomy which may lead to choledocholithiasis. Appropriate management requires timely identification and ERCP.

  5. Abscess mimicking lung metastasis in a 10-year-old boy – case report

    Malignant pulmonary tumours in children are very rare; the majority are metastases. Nonspecific radiographic findings of these abnormalities are challenging and may delay the final diagnosis and treatment. A 10-year-old boy was admitted to our hospital because of the clinical and radiographic symptoms and signs of pneumonia with abscess formation in the left lower lobe. After initial improvement on antibiotic therapy, a significant deterioration of the patient’s condition was observed, together with progression in radiographic examinations. The patient was treated surgically and transferred to the Haematology and Oncology Department with a final diagnosis of pulmonary metastasis of clear cell sarcoma. Radiographic findings of metastatic diseases may mimic non-neoplastic pulmonary conditions. A lack of specific clinical symptoms and a confusing radiographic pattern in our patient with clear cell sarcoma lung metastasis caused serious diagnostic difficulties

  6. Korean regulatory practices in clearance of solid materials-experience for the last 10 years

    Cheong, Jae Hak [KINS, Daejeon (Korea, Republic of)

    2005-11-15

    The Korean nuclear industry has more than 10 years experience of releasing slightly contaminated radioactive wastes, which have been generated during operation of nuclear facilities and use of radioisotopes, from regulatory control. Domestic legislations and regulations adopted the concept of clearance in 1994, based upon internationally endorsed dose criteria for clearance. A single concentration limit was set forth for short-lived beta/gamma emitting radionuclides. For waste streams containing other radionuclides, the feasibility of release has been determined on a case-by-case basis. Korea Institute of Nuclear Safety (KINS) derived draft clearance levels for other major radionuclides and proposed draft guidance for clearance in 2002. Since then, the case-by-case regulatory reviews have been performed based on the draft guidance. This paper introduces Korean legislations, regulations, regulatory review process, the characteristics of cleared waste, and safety research for implementing the concept of clearance.

  7. Invasive pulmonary aspergillosis 10 years post bone marrow transplantation: a case report

    Rashid Rifat

    2009-01-01

    Full Text Available Abstract Introduction Invasive pulmonary aspergillosis is a leading cause of mortality and morbidity in bone marrow transplant recipients. Establishing the diagnosis remains a challenge for clinicians working in acute care setting. However, prompt diagnosis and treatment can lead to favourable outcomes Case presentation We report a case of invasive aspergillosis occurring in a 39-year-old Caucasian female 10 years after an allogeneic haematopoietic bone marrow transplant, and 5 years after stopping all immunosuppression. Possible risk factors include bronchiolitis obliterans and exposure to building dust (for example, handling her husband's dusty overalls. There are no similar case reports in the literature at this time. Conclusion High clinical suspicion, especially in the setting of failure to respond to broad-spectrum antibiotics, should alert clinicians to the possibility of invasive pulmonary aspergillosis, which, in this case, responded to antifungal therapy.

  8. Physical therapy management of osteitis pubis in a 10-year-old cricket fast bowler.

    Sudarshan, A

    2013-08-01

    This case report describes a 10-year-old boy who presented with radiating pain (Visual Analog Scale score of 7.2 cm) down his left groin and was eventually diagnosed to have osteitis pubis. History revealed that he was exceeding the workload guidelines of bowling for a fast bowler. Examination findings were left sacro-iliac joint dysfunction, reduced left internal rotation of the hip, tightness of bilateral hip flexors and poor motor control of the lumbo-pelvic muscles. Physical therapy was aimed at correcting the sacro-iliac joint dysfunction, increasing the hip range of motion and muscle length along with exercises aimed at improving the lumbopelvic stability. The patient had complete resolution of pain by the ninth week and returned to fast bowling without any discomfort. PMID:23270404

  9. A 10-year follow up of reproductive function in women treated for childhood cancer

    Nielsen, Stine Nygaard; Andersen, A N; Schmidt, Kirsten Louise Tryde; Rechnitzer, C; Schmiegelow, K.; Bentzen, J G; Larsen, E C

    2013-01-01

    Previously, this study group found that female childhood cancer survivors could be at risk of early cessation of fertility. The aim of the present study was to evaluate reproductive function in the same group of survivors 10 years after the initial study. Of the original cohort of 100, 71 were re......-examined. Thirty-six survivors reported regular menstrual cycles. When they were compared with 210 controls, they differed significantly in antral follicle count (AFC) (median 15 versus 18, P=0.047) but not in anti-Müllerian hormone (AMH) (median 13.0 versus 17.8pmol/l). Survivors cured with minimal gonadotoxic...... treatment had significantly higher AMH and AFC compared with survivors cured with either potentially gonadotoxic treatment or treatment including alkylating chemotherapy and ovarian irradiation (20.0, 5.8 and...

  10. A case of pyogenic liver abscess in a 10-year-old girl

    Jung Lim Byun

    2010-05-01

    Full Text Available Pyogenic liver abscesses are rare in children. In pediatric patients, altered host defences seem to play an important role. However, pyogenic liver abscess also occurs in healthy children. We experienced a case of pyogenic liver abscess in a healthy immunocompetent 10-year-old-girl. The patient presented two distinct abscesses: one subphrenic and the other intrahepatic. The intrahepatic abscess resolved with percutaneous drainage and 3 weeks of parenteral antibiotic therapy but the subphrenic abscess which could not be drained needed prolonged parenteral antibiotic therapy in addition to oral antibiotic therapy. We performed follow-up serial CT scan of the abscess cavity to decide on the duration of antibiotic therapy. Here we present this case with a brief review of the literature.

  11. Tibial nerve intraneural ganglion cyst in a 10-year-old boy

    Intraneural ganglion cysts are uncommon cystic lesions of peripheral nerves that are typically encountered in adults. In the lower extremity, the peroneal nerve is most frequently affected with involvement of the tibial nerve much less common. This article describes a tibial intraneural ganglion cyst in a 10-year-old boy. Although extremely rare, intraneural ganglion cysts of the tibial nerve should be considered when a nonenhancing cystic structure with intra-articular extension is identified along the course of the nerve. This report also details the unsuccessful attempt at percutaneous treatment with US-guided cyst aspiration and steroid injection, an option recently reported as a viable alternative to open surgical resection. (orig.)

  12. The Program of the Second 10-Year Periodic In-Service Inspection in HANARO

    HANARO, an open-tank-in-pool type research reactor of 30 MWth power in South Korea, has been operating normally since its initial criticality in February, 1995. For the last ten years, HANARO has carried out the first 10- year periodic in-service inspections (ISI, as below) in accordance with Subsection IWD in ASME SEC. XI to verify the mechanical and structural integrities of an examined part. In 2004, HANARO updated the ISI program for the second straight year in accordance with the applicable code last edited in 1998. This paper describes the second ISI program, including the first ultrasonic volumetric test results of each primary pump flywheel bore and keyway according to the second ISI program

  13. Intercostal myositis ossificans misdiagnosed as osteosarcoma in a 10-year-old child

    Myositis ossificans (MO) is a rare benign cause of heterotopic bone formation within soft tissue. It most commonly affects adolescents and young adults, typically in the limbs and following trauma. Very few cases have been reported in children. We report here a case of nontraumatic MO occurring in a 10-year-old girl with an uncommon location in the 5th right intercostal space; it was initially misdiagnosed and treated as osteosarcoma. Imaging findings including plain radiographs, CT, MRI, bone scintigraphy and PET-CT are described. This case highlights the central role played by imaging in diagnosis, thus avoiding biopsy that can erroneously suggest osteosarcoma as the diagnosis, as occurred in this case. (orig.)

  14. Prevalence of intestinal parasitic infections in Jenin Governorate, Palestine:a 10-year retrospective study

    Sami Bdir; Ghaleb Adwan

    2010-01-01

    Objective:To assess the prevalence of intestinal parasites among Jenin Governorate (Northern Palestine) population.Methods:A retrospective laboratory analysis of stool specimens was carried out for intestinal parasite examination in Jenin Governmental Hospital, Jenin Governorate, Northern Palestine. The records were collected from the clinical microbiology laboratory of the Jenin Governmental Hospital between January2000and December2009. Results: Our retrospective study showed that the prevalence of intestinal parasite infection during10 years ranged from32.0-41.5%. There are at least7 different parasitesencountered. The most common pathogenic parasites identified were:Entamoeba histolytica(8.2-18.2%),Enterobius vermicularis(15.6-28.9%). The other parasites present wereGiardia lamblia, Ascaris lumbricoides, Strongyloides stercoralis,Taenia species andAncylostoma duodenale (Hookworms).Conclusions:Intestinal parasitic infection is an important public health problem in Jenin governorate, Palestine. It is necessary to develop effective prevention and control strategies including health education and environmental sanitation improvement.

  15. Pseudoangiomatous stromal hyperplasia of the breast in a 10-year-old girl.

    Baker, Michael; Chen, Hui; Latchaw, Laurie; Memoli, Vincent; Ornvold, Kim

    2011-08-01

    Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion, characterized by a dense proliferation of stromal mesenchymal cells of myofibroblastic origin forming empty, slitlike channels. The development of PASH is subject to hormonal influence and is most commonly seen in premenopausal women. In adolescent patients, PASH is rarely reported. Here we report a case of PASH presenting in a 10-year-old girl. After the presentation and inconclusive radiographic findings, incisional biopsy revealed a soft nodule with histopathologic features characteristic of PASH. Immunoperoxidase studies showed positive immunoreactivity for CD34 and bcl-2 and negative immunoreactivity for CD31 and desmin, supporting the diagnosis of PASH. Because of the benign nature of the lesion, excisional biopsy was deferred to minimize damage to the patient's developing breast. To our knowledge, this case represents the youngest female patient with unequivocal PASH in reported literature. PMID:21843705

  16. [Analysis on characteristics of red tide in Fujian coastal waters during the last 10 years].

    Li, Xue-Ding

    2012-07-01

    There were 161 red tide events collected during the last 10 years from 2001 to 2010 in Fujian coastal waters. Comprehensive analysis was performed using statistical methods and the results indicated the following characteristics of the temporal and spatial distribution of red tide in Fujian coastal waters: (1) Outbreaks of red tide often occurred between April and September, and the peak period was in May and June. Most red tide events lasted for 2 to 4 days, and the affected area was below 50 square kilometers. The first outbreak of red tide tended to occur earlier in recent years, and the lasting time became longer. (2) There were 20 species of organisms causing the red tides in Fujian coastal waters, among which 10 species were Bacillariophyta, 9 species were Dinophyta and 1 species was Protozoa. Prorocentrum donghaiense was the most frequent cause of red tides, followed by Noctiluca scintillans, Skeletonema costatum and Chaetoceros sp.. The species caused red tides obeyed the succession law and there were always new species involved. (2) In terms of spatial distribution, outbreaks of red tides mainly occurred in the coastal waters of Ningde, Fuzhou and Xiamen. The species causing red tides were Prorocentrum donghaiense and Noctiluca in the coastal waters in the north of Pingtan, Fujian Province, Skeletonema costatum and Chaetoceros in the coastal waters in the south of Pingtan, Fujian Province. The comprehensive analysis of the characteristics of red tides during the last 10 years is expected to provide scientific and reasonable basis for the prevention, reduction and forecast of red tides in Fujian coastal waters. PMID:23002593

  17. Over 10 years follow-up of Coats' disease in adulthood

    Otani T

    2011-12-01

    Full Text Available Tatsuro Otani1, Kanako Yasuda1, Naoko Aizawa2, Fumiaki Sakai3, Toru Nakazawa2, Masahiko Shimura11Department of Ophthalmology, NTT East Japan Tohoku Hospital, 2Department of Ophthalmology, Tohoku University School of Medicine, 3Heisei Ophthalmic Associates P.O., Sendai, Miyagi, JapanAbstract: Coats' disease diagnosed in adulthood is rare; therefore, the treatment options and longer clinical course are not well established. We report on two cases of adult onset Coats' disease, which have been observed for more than 10 years after conventional treatment. In the first case, a 76-year-old man with 9 years of diabetic retinopathy noticed a visual field defect in his left eye. Yellowish subretinal exudation with serous retinal detachment in his superior peripheral retina, and telangiectatic vessels with fluorescein leakage, numerous microaneurysms, and areas of capillary nonperfusion observed in a fluorescein angiography indicated adult Coats' disease, and retinal photocoagulation was applied. Within 1 year, subretinal exudation was regressed and visual acuity was improved from 20/50 to 20/20, and was maintained for the next 11 years. In the second case, a 71-year-old man presented with decreased vision in his right eye. The fundus of his right eye showed multiple telangiectasic vessels and subretinal exudates extended to the fovea, which is diagnosed as adult Coats’ disease. Despite retinal photocoagulation, an increase of exudation and an enlargement of retinal detachment was observed within 1 month, and subsequently, additional treatment of cryotherapy was performed. Two months after these therapies, the exudation was regressed without retinal detachment, and visual acuity was improved to 20/200 which was maintained for the next 10 years. Even with adult Coats’ disease, conventional therapies of retinal photocoagulation and cryotherapy are effective and are the initial choice for improving or maintaining visual function.Keywords: adult onset

  18. Patient-reported outcomes as predictors of 10-year survival in women after acute myocardial infarction

    Segadal Leidulf

    2010-11-01

    Full Text Available Abstract Background Patient-reported outcomes are increasingly seen as complementary to biomedical measures. However, their prognostic importance has yet to be established, particularly in female long-term myocardial infarction (MI survivors. We aimed to determine whether 10-year survival in older women after MI relates to patient-reported outcomes, and to compare their survival with that of the general female population. Methods We included all women aged 60-80 years suffering MI during 1992-1997, and treated at one university hospital in Norway. In 1998, 145 (60% of those alive completed a questionnaire package including socio-demographics, the Sense of Coherence Scale (SOC-29, the World Health Organization Quality of Life Instrument Abbreviated (WHOQOL-BREF and an item on positive effects of illness. Clinical information was based on self-reports and hospital medical records data. We obtained complete data on vital status. Results The all-cause mortality rate during the 1998-2008 follow-up of all patients was 41%. In adjusted analysis, the conventional predictors s-creatinine (HR 1.26 per 10% increase and left ventricular ejection fraction below 30% (HR 27.38, as well as patient-reported outcomes like living alone (HR 6.24, dissatisfaction with self-rated health (HR 6.26, impaired psychological quality of life (HR 0.60 per 10 points difference, and experience of positive effects of illness (HR 6.30, predicted all-cause death. Major adverse cardiac and cerebral events were also significantly associated with both conventional predictors and patient-reported outcomes. Sense of coherence did not predict adverse events. Finally, 10-year survival was not significantly different from that of the general female population. Conclusion Patient-reported outcomes have long-term prognostic importance, and should be taken into account when planning aftercare of low-risk older female MI patients.

  19. Injuries in a Professional Ballet Dance Company: A 10-year Retrospective Study.

    Ramkumar, Prem N; Farber, Joseph; Arnouk, Johnny; Varner, Kevin E; Mcculloch, Patrick C

    2016-03-01

    Ballet dancers are high-performance athletes who are particularly susceptible to a wide variety of musculoskeletal injuries. However, they are relatively understudied, and data on their injury rates are lacking. This retrospective study features the largest aggregate data on professional ballet dancers to date and aims to identify the most common diagnoses and areas of injury in this unique population to better direct preventative and clinical practices. The study encompassed a 10-year period from January 2000 to December 2010 of dancers from a single company. Data regarding the dancers' age, gender, location of injury, and diagnosis were collected from workers' compensation claims, company records, and medical records maintained by the treating doctors. These were analyzed to determine metrics on injury incidence, frequency, and diagnosis. Over the 10-year span, 574 injuries occurred. There were approximately 52 dancers per year for a total of 153 who danced at least one complete season during the study period. The average age was 27, and 53% were female. Given turnover with retirement and replacements, the total number of dancer-years was 520, indicating an injury incidence per annum of 1.10 (574 injuries per 520 dancer-years). The most common locations of injury were foot and ankle and the lumbar spine, with the three most common diagnoses making up greater than a third (37%) of the total. As the current largest study in professional ballet, the findings set the benchmark metrics for musculoskeletal injury to the foot, ankle, and lumbar spine sites. Future studies should aim to identify injury risk factors and modalities for prevention of these injuries. PMID:27025450

  20. Epidemiological, Clinical and Paraclinical Study of Hydatid Cysts in Three Educational Medical Centers in 10 Years

    Simindokht Shoaee

    2016-01-01

    Full Text Available Background: Echinococcosis or hydatidosis, caused by the larval stage of Echinococcus granulosus (E. granulosus, is an important public health problem in many areas of the world  and  Iran is a country of endemic situation for hydatidosis In the present study, we evaluated epidemiological, complications and clinical characteristics of hydatidosis at three University Medical Centers in Tehran over a 10-year period.Materials and Methods: This is a descriptive cross-sectional study performed in patients with hydatid cysts. Information about age, gender, number of cysts, organ involvement, morbidity and mortality and relapse were collected from medical records of hydatid patients. Paraclinic information such as CT Scan, MRI, ultrasound, complete blood count, pathological diagnosis and complication of disease were collected.Results: Overall, 81 patients, 35 (43.2% male and 46 (56.8% female, who were diagnosed as having hydatid cyst by clinical and radiological findings, with pathologic documentation were studied in three university medical center registries over a 10-year period (2003- 2012 in Tehran. Fourteen patients (17% of cases had complications resulting from this disease. Patients' age ranged from 5 to 86 years, and the peak prevalence of the disease was between 20 and 40 (34% of cases.Conclusion: Iran  is a country of endemic situation for hydatidosis. Prevalence rate of hydatidosis in Iran was reported to be 0.61-2 in 100000 populations. The highest  rate of infection and complications were in patients of 20-40 years age. Clinical examination revealed that abdominal pain was the most common complaint and was present in 51.7% of the cases. Other most common complain were cough, abdominal mass, dyspnea, icterus, chest pain, dyspepsia, back pain and seizure; and it was result of occupying effect of cysts in organs. This is similar with previous studies in Iran

  1. Lamont-Doherty's Secondary School Field Research Program: 10 years of field research-based education.

    Newton, R.; Vincent, S.; Gribbin, S.; Peteet, D. M.; Sambrotto, R.; Bostick, B. C.; Corbett, E.; Nguyen, K.; Bjornton, J.; Lee, D.; Dubossi, D.; Reyes, N.

    2014-12-01

    This fall marks the 10th year in which we have run a research-project-based educational program for high school students and science teachers at the Lamont-Doherty Earth Observatory. This summer's cohort included 31 teenagers, 7 science teachers, and 16 college students, most of whom are returning to the program to help run the research projects. Nearly all of our students attend non-competitive-entry public schools in NYC or the neighborhoods around the Observatory. Over 80% are from under-served minority populations. Most receive Title I/III assistance. About 60% are young women. During the past 10 years, nearly all of our participants have gone on to 4-year colleges. About half are declaring science and engineering majors. Our students receive scholarship support at rates several times higher than their graduating peers, including 5 Gates Millennium scholars over the past 5 years. Our science is centered on studies of a nearby tidal wetland, where we have expanded from fish collections in year one to include everything from sediment core analysis to soil chemistry to nutrient cycles to the local food web. In this presentation we will look back over 10 years of experience and focus on what lessons can be learned about (1) how to engage teams of young investigators in authentic scientific research; (2) what cultural/organizational structures encourage them to make use of place- and project-based learning and (3) what the participants themselves report as the most useful aspects of our programming. The presentation will include video clips from the students' field experiences and from reflective interviews with "graduates".

  2. Prematures with and without Regressed Retinopathy of Prematurity: Comparison of Long-Term (6-10 Years) Ophthalmological Morbidity.

    Cats, Bernard P.; Tan, Karel E. W. P.

    Reporting long-term ophthalmologic sequelae among ex-prematures at 6 to 10 years of age, this study compares 42 ex-premature infants who had had regressed forms of retinopathy of prematurity (ROP) during the neonatal period with 42 matched non-ROP ex-premature controls at 6 to 10 years of age. Subjects were subdivided into four groups: (1) ROP…

  3. Predictors of Childhood Anxiety: A Population-Based Cohort Study.

    Dawn Kingston

    Full Text Available Few studies have explored predictors of early childhood anxiety.To determine the prenatal, postnatal, and early life predictors of childhood anxiety by age 5.Population-based, provincial administrative data (N = 19,316 from Manitoba, Canada were used to determine the association between demographic, obstetrical, psychosocial, medical, behavioral, and infant factors on childhood anxiety.Risk factors for childhood anxiety by age 5 included maternal psychological distress from birth to 12 months and 13 months to 5 years post-delivery and an infant 5-minute Apgar score of ≤7. Factors associated with decreased risk included maternal age < 20 years, multiparity, and preterm birth.Identifying predictors of childhood anxiety is a key step to early detection and prevention. Maternal psychological distress is an early, modifiable risk factor. Future research should aim to disentangle early life influences on childhood anxiety occurring in the prenatal, postnatal, and early childhood periods.

  4. A population-based study of birth defects in Malaysia.

    Thong, M K; Ho, J J; Khatijah, N N

    2005-01-01

    Birth defects are one of the leading causes of paediatric disability and mortality in developed and developing countries. Data on birth defects from population-based studies originating from developing countries are lacking. One of the objectives of this study was to determine the epidemiology of major birth defects in births during the perinatal period in Kinta district, Perak, Malaysia over a 14-month period, using a population-based birth defect register. There were 253 babies with major birth defects in 17,720 births, giving an incidence of 14.3/1000 births, a birth prevalence of 1 in 70. There were 80 babies with multiple birth defects and 173 with isolated birth defects. The exact syndromic diagnosis of the babies with multiple birth defects could not be identified in 18 (22.5%) babies. The main organ systems involved in the isolated birth defects were cardiovascular (13.8%), cleft lip and palate (11.9%), clubfeet (9.1%), central nervous system (CNS) (including neural tube defects) (7.9%), musculoskeletal (5.5%) and gastrointestinal systems (4.7%), and hydrops fetalis (4.3%). The babies with major birth defects were associated with lower birth weights, premature deliveries, higher Caesarean section rates, prolonged hospitalization and increased specialist care. Among the cohort of babies with major birth defects, the mortality rate was 25.2% during the perinatal period. Mothers with affected babies were associated with advanced maternal age, birth defects themselves or their relatives but not in their other offspring, and significantly higher rates of previous abortions. The consanguinity rate of 2.4% was twice that of the control population. It is concluded that a birth defects register is needed to monitor these developments and future interventional trials are needed to reduce birth defects in Malaysia. PMID:16096215

  5. Study of maternal mortality trends: 10 years retrospective and comparative analysis at a tertiary teaching hospital of Gwalior Chambal region

    Jyoti Bindal

    2016-03-01

    Conclusions: Delay in seeking emergency obstetric care and not having regular antenatal checkups by pregnant females are the major contributors for maternal mortality. Dedicated obstetric intensive care units at referral centers for prompt and comprehensive care may help in reducing the maternal morbidity and mortality. [Int J Reprod Contracept Obstet Gynecol 2016; 5(3.000: 730-733

  6. Bowel, Urinary, and Sexual Problems Among Long-Term Prostate Cancer Survivors: A Population-Based Study

    Purpose: To obtain insight into the long-term (5- to 10-year) effects of prostate cancer and treatment on bowel, urinary, and sexual function, we performed a population-based study. Prostate-specific function was compared with an age-matched normative population without prostate cancer. Methods and Materials: Through the population-based Eindhoven Cancer Registry, we selected all men diagnosed with prostate cancer between 1994 and 1998 in the southern Netherlands. In total, 964 patients, alive in November 2004, received questionnaire; 780 (81%) responded. Results: Urinary problems were most common after a prostatectomy; bowel problems were most common after radiotherapy. Compared with an age-matched normative population both urinary and bowel functioning and bother were significantly worse among survivors. Urinary incontinence was reported by 23-48% of survivors compared with 4% of the normative population. Bowel leakage occurred in 5-14% of patients compared with 2% of norms. Erection problems occurred in 40-74% of patients compared with 18% of norms. Conclusions: These results form an important contribution to the limited information available on prostate-specific problems in the growing group of long-term prostate cancer survivors. Bowel, urinary, and sexual problems occur more often among long-term survivors compared with a reference group and cannot be explained merely by age. Because these problems persist for many years, urologists should provide patients with adequate information before treatment. After treatment, there should be an appropriate focus on these problems

  7. The radiological spectrum of invasive aspergillosis in children: a 10-year review

    Thomas, Karen E. [Department of Diagnostic Radiology, Great Ormond Street Hospital for Children, Great Ormond Street, London (United Kingdom); Department of Diagnostic Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8 (Canada); Owens, Catherine M. [Department of Diagnostic Radiology, Great Ormond Street Hospital for Children, Great Ormond Street, London (United Kingdom); Veys, Paul A.; Novelli, Vas; Costoli, Vera [Host Defence Unit, Great Ormond Street Hospital for Children, London (United Kingdom)

    2003-07-01

    Invasive aspergillosis is an uncommon but life-threatening event in the immunocompromised child. Attempts at fungal isolation are often unrewarding and a high index of radiological suspicion is essential in the early diagnosis of infected children. To document the radiological spectrum of disease in invasive aspergillosis in the paediatric population. A retrospective review of the imaging performed in 27 consecutive patients (age 7 months to 18 years) with documented invasive Aspergillosis encountered over a 10-year period at a single institution. Radiographic findings of pulmonary disease (20 patients) included segmental and multilobar consolidation, perihilar infiltrates, multiple small nodules, peripheral nodular masses and pleural effusions. No cavitating lesions were seen on CXR. Small cavitating nodules were present on CT in two of eight children. Chest wall disease was particularly associated with underlying chronic granulomatous disease. Disseminated disease manifested as osteomyelitis (n=5), cerebral (n=3), oesophageal (n=1), hepatic (n=2), renal (n=2) and cutaneous (n=5) involvement. Imaging findings are discussed. Twelve patients (44%) subsequently died from Aspergillus-related complications. Invasive aspergillosis presents with a wide variety of radiographic findings involving multiple organ systems. Respiratory findings are varied but often non-specific, and a high index of suspicion is necessary in immunocompromised patients. In contrast to adult disease, the incidence of cavitation of pulmonary lesions appears low. (orig.)

  8. The radiological spectrum of invasive aspergillosis in children: a 10-year review

    Invasive aspergillosis is an uncommon but life-threatening event in the immunocompromised child. Attempts at fungal isolation are often unrewarding and a high index of radiological suspicion is essential in the early diagnosis of infected children. To document the radiological spectrum of disease in invasive aspergillosis in the paediatric population. A retrospective review of the imaging performed in 27 consecutive patients (age 7 months to 18 years) with documented invasive Aspergillosis encountered over a 10-year period at a single institution. Radiographic findings of pulmonary disease (20 patients) included segmental and multilobar consolidation, perihilar infiltrates, multiple small nodules, peripheral nodular masses and pleural effusions. No cavitating lesions were seen on CXR. Small cavitating nodules were present on CT in two of eight children. Chest wall disease was particularly associated with underlying chronic granulomatous disease. Disseminated disease manifested as osteomyelitis (n=5), cerebral (n=3), oesophageal (n=1), hepatic (n=2), renal (n=2) and cutaneous (n=5) involvement. Imaging findings are discussed. Twelve patients (44%) subsequently died from Aspergillus-related complications. Invasive aspergillosis presents with a wide variety of radiographic findings involving multiple organ systems. Respiratory findings are varied but often non-specific, and a high index of suspicion is necessary in immunocompromised patients. In contrast to adult disease, the incidence of cavitation of pulmonary lesions appears low. (orig.)

  9. A 10-year review of four academic nurse-managed centers: challenges and survival strategies.

    King, Eunice S

    2008-01-01

    Since 1985, there has been rapid growth in nurse-managed health centers (NMHCs). Many were established by academic schools of nursing, and several have closed. The Independence Foundation undertook this study to identify the challenges and survival strategies employed by four academic nurse-managed center grantees during a 10-year period. Data from Foundation records, interviews with directors and staff from the centers and the National Nursing Centers Consortium, a focus group with center founders, and field notes were analyzed for themes related to the centers' challenges and survival strategies. Although the centers faced many challenges from the sociopolitical environment, the community, and their parent organizations, the most difficult challenge was achieving financial sustainability, which was attainable only by obtaining cost-based reimbursement. Because of existing health policies, that was possible only through organizational restructuring and affiliation with an existing federally qualified health center. The future of nursing centers depends upon favorable health policies, data documenting centers' effectiveness, and adequate preparation of the next generation of nursing center directors and practitioners. PMID:18206838

  10. The Effect of Executive Function on Science Achievement Among Normally Developing 10-Year Olds

    Lederman, Sheri G.

    Executive function (EF) is an umbrella term used to identify a set of discrete but interrelated cognitive abilities that enable individuals to engage in goal-directed, future-oriented action in response to a novel context. Developmental studies indicate that EF is predictive of reading and math achievement in middle childhood. The purpose of this study was to identify the association between EF and science achievement among normally developing 10 year olds. A sample of fifth grade students from a Northeastern suburban community participated in tests of EF, science, and intelligence. Consistent with adult models of EF, principal components analysis identified a three-factor model of EF organization in middle childhood, including cognitive flexibility, working memory, and inhibition. Multiple regression analyses revealed that executive function processes of cognitive flexibility, working memory, and inhibition were all predictive of science performance. Post hoc analyses revealed that high-performing science students differed significantly from low-performing students in both cognitive flexibility and working memory. These findings suggest that complex academic demands specific to science achievement rely on the emergence and maturation of EF components.

  11. Pleomorphic Adenoma of the Palate in a 10-year-old Child: A Case Report

    SH Tabatabaei

    2016-03-01

    Full Text Available Salivary gland tumors  are  uncommon  within  children and  when  they do arise,  they  mainly  affect  the  major  salivary glands. Minor salivary gland  tumors  are  rare  in  children, which are  responsible for less than 10% of all the cases. Pleomorphic adenoma is the most common tumor of  the salivary glands in the all ages. A 10-year-old boy referred to the dentistry clinic with a swelling in the palate of adjacent unerupted right maxillary second molar. In sampling by curettage, clinical pathologist reported ameloblastoma. The patient was referred to the dental school of Shahid Sadoughi University of Medical Sciences for consultation. Second  microscopic analysis showed a benign pleomorphic adenoma that was confirmed by special staining periodic acid-Schiff (PAS, immunohistochemistry cytokeratin(CK, and S100 staining. Pleomorphic adenoma of minor salivary gland of children should be considered as a differential diagnosis of intraoral swelling in the palate.

  12. Dynamics of comprehensive physical fitness in artistic gymnasts aged 7-10 years

    Boraczyńska Sandra

    2014-12-01

    Full Text Available Purpose: The aim of the study was to evaluate the somatic development and comprehensive physical fitness of artistic gymnasts aged 7-10 years. Materials and methods: Gymnasts (n = 307, split up into four age groups performed eight Eurofit tests. The results were evaluated in points according to the development standards prepared in scale T for the Polish girls population. Results : The gymnasts obtained the highest growth rate in balance test - FLB (13 points, arm and shoulder muscular endurance test - BAH (7 points and speed of the upper limb movement test - PLT (4 points out of eight physical fitness tests. Conclusions. High and very high level of performance in the six Eurofit tests and increased total number of points in the subsequent age groups of artistic gymnasts proved high effectiveness of training in shaping the key components of a comprehensive physical fitness in artistic gymnastics - balance, strength, endurance, speed and flexibility. Relatively little progress in isometric hand strength (HGR and standing broad jump (SBJ suggests a significant influence of genetic factors on the level of these abilities. The results provide an objective information useful in optimizing control system of training effects in comprehensive physical fitness and optimization of artistic gymnasts training at the comprehensive stage of sports training.

  13. Factors affecting diatom dynamics in the alpine lakes of Colbricon (Northern Italy: a 10-year survey

    Andrea SQUARTINI

    2010-08-01

    Full Text Available Planktonic diatom fluctuations, their diversity and relationships with environmental variables were analyzed for ten consecutive years in Colbricon Superiore and Inferiore, two small high-mountain lakes located in the Paneveggio-Pale di S. Martino Natural Park (Trento, Italy offering the rare opportunity to study two lakes differing only by area and volume and being in this respect in a ratio of 2:1 and 3:1 respectively. The lakes were monitored and sampled monthly, during ten ice-free periods, from 1998 to 2007, to correlate water chemical and physical characteristics with the recorded diversity and abundance of planktonic diatoms. 55 taxa of Bacillariophyceae were found, among which Cyclotella spp., Tabellaria flocculosa and Fragilaria spp. were dominant. Both chemical data and diatom community composition are consistent with well buffered mesotrophic lakes. We found statistical evidence that the development of diatoms was strongly related to the variation of water temperature. Furthermore, several different signatures of the diatom-enviroment relationships arose between the two lakes as e.g., a negative correlation between diatom development and water transparency was occurring in the larger lake only. As a result, the average diatom density recorded over the 10 years period were 1.17 fold higher than in the lower lake which corresponds to a 1.65 fold higher biomass. A size-dependent tighter response of the phytoplankton to chemical parameters appears to operate in the smaller waterbody compared to the larger one.

  14. Medullary hemopoiesis: studying during 10 years period after Chernobyl atomic power station accident

    Results of the study of bone marrow haemopoiesis study in 1077 female white rats nursed in R.E.Kavetsky Institute and kept during their lifespan in Chernobyl and Kyiv animal facilities for 10 years since 1986, are presented. The most expressed lesions in haemopoietic system were revealed in the first group of animals (1986-1989 years): a decrease in total bone marrow cellularity and mitotic activity, leukopenia with lympho-and granulocytopeniya, absolute eosinophylia. During the next years general tendency to a decrease of myeloid tissue potention was detected, but no significant variations in bone marrow cellularity and peripheral blood indices were revealed. At the same time, specific cells valuable for prognosis appeared in blood at that point. These are large lymphocytes with lobular or 'shriveled leaf' nucleus, simultaneously influencing the selection of the direction of haemopoietic stem cell differentiation and antitumor resistance of the body. Informative prognostic sign of the bone marrow injury rate based on the distribution percent of animals with different leukocyte number was established

  15. Spatiotemporal Trends Analysis of Pyrethroid Sediment Concentrations Spanning 10 Years in a Residential Creek in California.

    Hall, Lenwood W; Anderson, Ronald D; Killen, William D

    2016-02-01

    The objective of this study was to assess temporal and spatial trends for eight pyrethroids monitored in sediment spanning 10 years from 2006 to 2015 in a residential stream in California (Pleasant Grove Creek). The timeframe for this study included sampling 3 years during a somewhat normal non-drought period (2006-2008) and 3 years during a severe drought period (2013-2015). Regression analysis of pyrethroid concentrations in Pleasant Grove Creek for 2006, 2007, 2008, 2012, 2013, 2014, and 2015 using ½ the detection limit for nondetected concentrations showed statistically significant declining trends for cyfluthrin, cypermethrin, deltamethrin, permethrin, and total pyrethoids. Additional trends analysis of the Pleasant Grove Creek pyrethroid data using only measured concentrations, without nondetected values, showed similar statistically significant declining trends for cyfluthrin, cypermethrin, deltamethrin, esfenvalerate, fenpropathrin, permethrin, and total pyrethroids. Spatial trends analysis for the specific creek sites showed that six of the eight pyrethroids had a greater number of sites with statistically significant declining concentrations. Possible reasons for reduced pyrethroid concentrations in the stream bed in Pleasant Grove Creek during this 10-year period are label changes in 2012 that reduced residential use and lack of precipitation during the later severe drought years of 2013-2015. PMID:26643307

  16. VARIABILITY OF LUMINOUS STARS IN THE LARGE MAGELLANIC CLOUD USING 10 YEARS OF ASAS DATA

    Motivated by the detection of a recent outburst of the massive luminous blue variable LMC-R71, which reached an absolute magnitude MV = -9.3 mag, we undertook a systematic study of the optical variability of 1268 massive stars in the Large Magellanic Cloud, using a recent catalog by Bonanos et al. as the input. The ASAS All Star Catalog provided well-sampled light curves of these bright stars spanning 10 years. Combining the two catalogs resulted in 599 matches, on which we performed a variability search. We identified 117 variable stars, 38 of which were not known before, despite their brightness and large amplitude of variation. We found 13 periodic stars that we classify as eclipsing binary (EB) stars, 8 of which are newly discovered bright massive EBs composed of OB-type stars. The remaining 104 variables are either semi- or non-periodic, the majority (85) being red supergiants (RSGs). Most (26) of the newly discovered variables in this category are also RSGs with only three B and four O stars.

  17. Does gymnastics practice improve vertical jump reliability from the age of 8 to 10 years?

    Marina, Michel; Torrado, Priscila

    2013-01-01

    The objective of this study was to confirm whether gymnastics practice from a young age can induce greater vertical jump reliability. Fifty young female gymnasts (8.84 ± 0.62 years) and 42 females in the control group (8.58 ± 0.92 years) performed the following jump tests on a contact mat: squat jump, countermovement jump, countermovement jump with arm swing and drop jump from heights of 40 and 60 cm. The two testing sessions had three trials each and were separated by one week. A 2 (groups) × 2 (sessions) × 3 (trials) repeated measures analysis of variance (ANOVA) and a test-retest correlation analysis were used to study the reliability. There was no systematic source of error in either group for non-plyometric jumps such as squat jump, countermovement jump, and countermovement jump with arm swing. A significant group per trial interaction revealed a learning effect in gymnasts' drop jumps from 40 cm height. Additionally, the test-retest correlation analysis and the higher minimum detectable error suggest that the quick drop jump technique was not fully consolidated in either group. At an introductory level of gymnastics and between the ages of 8-10 years, the condition of being a gymnast did not lead to conclusively higher reliability, aside from better overall vertical jump performance. PMID:23414426

  18. Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years.

    Wang, Xiao Yun; Jakowski, Joseph; Tawfik, Ossama W; Thomas, Patricia A; Fan, Fang

    2009-06-01

    Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma. In our effort to characterize the clinicopathologic features of breast angiosarcoma, we reviewed all breast angiosarcoma cases in the University of Kansas Medical Center and Ohio State University Medical Center archives from 1997 to 2007. Clinical histories and follow-up data for identified patients were reviewed. The tumors were graded histologically according to Rosen's method. Only 11 angiosarcomas were identified among more than 5000 malignant breast neoplasms (0.1%-0.2% incidence) for the last 10 years. Eight cases (6 high grade, 1 intermediate grade, 1 low grade) were identified as postradiation angiosarcoma (postradiation time interval, 4-12 years), and 3 cases were identified as primary angiosarcomas (1 high grade, 2 low grade). Follow-up (median, 36 months) revealed that 3 cases of postradiation angiosarcoma recurred as skin and/or chest wall lesions and 1 case of primary angiosarcoma developed liver metastases (all high-grade). In conclusion, breast angiosarcoma remains a rare disease. Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome. There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas. PMID:19433291

  19. Accomplishment of 10-year research in NUCEF and future development. Actinides science research

    The research relevant to nuclear fuel cycle technologies has been made in NUCEF. One of the main topics in 10-year research in NUCEF is that a new experimental facility for high temperature chemistry of transuranium elements (TRU), called TRU-HITEC, has been installed in NUCEF and is under operation. TRU-HITEC consists of three alpha/gamma cells shielded by steel and polyethylene and a glove box, where experimental apparatuses are equipped and a high purity argon gas atmosphere is maintained. In TRU-HITEC, Am-241, Am-243, Cm-244, Np-237, Pu, U and spent fuel can be handled. The research activities at TRU-HITEC are the measurements of chemical and electrochemical behavior of minor actinides (MA) in molten salts for the pyrochemical processes, and the fabrication and property measurements of MA-bearing fuel. Besides the research at TRU-HITEC, the non-destructive and destructive analyses of spent LWR fuels to obtain basic data for the burnup credit, the chemical analyses of irradiated actinide samples for evaluation of the capture and fission cross sections, and the research on the rock-like oxide (ROX) fuel for Pu-burning in LWRs were successfully made. (author)

  20. TVA's first 10 years of nuclear plant design and construction experience

    TVA has been actively involved in the design and construction of large nuclear power plants for nearly 12 years. During this time, the three-unit Browns Ferry plant has been completed and is in commercial operation; six more plants with 14 units are in various stages of construction or authorization. This total capacity of 21,574 megawatts in nuclear power is the largest commitment by a single power system and represents an ultimate investment of $12 billion by 1986. The experience of TVA's design and construction program in terms of schedule and capital costs in three separate phases is reviewed. Phase one recapitulates the status of the nuclear power industry in 1966 and sets forth the assumptions used for estimating capital costs and projecting project schedules for the first TVA units. Phase Two describes what happened to the program in the early 1970s in terms of expansion of scope (particularly for safety features), the dramatic increase in regulatory requirements, vendor problems, stretchout of project schedules and unprecedented inflation. Phase Three addresses the assumptions used today in estimating schedules and plant costs for the next 10-year period

  1. A tentative 10-year sediment budget of the lower River Ebro (NE Iberian Peninsula)

    Tena, A.; Batalla, R. J.; Vericat, D.; López-Tarazón, J. A.

    2009-04-01

    Dams in the Ebro basin alter flow regime and sediment transport of most rivers in the catchment. This fact, together with changes in land use, results in a sustained decrease of the sediment load since the beginning of the 20th century, with special impact on the sediment load of the lower reaches of the river. The aim of this work is to develop a long-term suspended sediment budget for the river reach downstream the largest complex of dams in the basin (Mequinenza-Ribarroja-Flix, impounding around 1.7 km3 of water). As a first step we have estimated the river's sediment load over a 10-year period based on turbidity and water discharge records continuously measured by the Ebro Water Authorities. Turbidity measurements have been calibrated by means of five-hundred manual water samples collected during all flow conditions (i.e. floods and low flows) between 2002 and 2008. Water samples have been collected 28 km downstream from the lowermost Flix Dam, at the Mora d'Ebre Monitoring Section (hereafter MEMS). Discharge at MEMS is estimated by routing the flow hydrographs from the Asc

  2. Sustained stimulation of soil respiration after 10 years of experimental warming

    A number of forest and grassland studies indicated that stimulation of the soil respiration by soil warming ceases after a couple of years (Luo et al 2001 Nature 413 622-5). Here we present results from a long-term soil warming lysimeter experiment in southern Germany showing sustained stimulation of soil respiration after 10 years. Moreover, both warmed and control treatments exhibited a similar temperature response of soil respiration, indicating that adaptation in terms of temperature sensitivity was absent. Carbon dioxide concentration measurements within the profiles are supporting these findings. The increased soil respiration occurred although vegetation productivity in the warmed treatment was not higher than in the control plots. These findings strongly contrast with current soil carbon modeling concepts, where carbon pools decay according to first-order kinetics, and thus a depletion of labile soil carbon pools leads to an apparent down-regulation of microbial respiration (Knorr et al 2005 Nature 433 298-301). Consequently, the potential for positive climate carbon cycle feedback may be larger than represented in current models of soil carbon turnover.

  3. In situ Tournemire argillite / iron metal interactions: results after 10 years

    Within the framework of a long lived radioactive waste storage concept in deep geological layer developed by Andra, IRSN leads an in situ study on the Experimental Station of Tournemire, in association with EDF to determine the interactions steel/argillite in a natural context. After 10 years of interaction, two drillings overcoring performed to characterize the processing of the Tournemire argillite in contact with carbon and stainless steels and to compare reactive phenomena highlighted and those induced by simulations tools combining chemistry and transport. Argillite/carbon steel samples show a significant corrosion of steel disk. Iron released, in the form of rings and cracks in the rock, disrupts the argillite in contact resulting in mineralogical and structural changes. Iron oxides precipitation and a calcite and smectitic leaf of mixed-layers I/S dissolution are identified. A succession of areas: metal/metal corroded/argillite disturbed/argillite is highlighted and porosity variations are observed on the interfaces between two areas. Geochemical simulations show that major changes are initiated speedily during establishment of the system and the oxygen trapped in the closed system is consumed by the corrosion of steel but mostly it diffuses into the surrounding material through concentration gradient. Argillite/stainless steel samples have a very low pitting corrosion of steel disk. This does not seem to affect the mineralogy of the argillite in contact. (author)

  4. Hip arthroscopy in the warrior athlete: 2 to 10 year outcomes.

    Byrd, J W Thomas; Jones, Kay S; Schmitz, LtCol Matthew R; Doner, Geoffrey P

    2016-04-01

    Hip disorders are increasingly recognized among athletic populations. The rigors of military service expose individuals to the same risks as those participating in competitive sports, compounded by potential exposure to violent macrotrauma. This is a retrospective review of prospectively collected data among 62 active duty military personnel (64 hips) with 2-10-year follow-up. Follow-up averaged 47 months (range 24-120 months). The average age was 30 years (range 17-53 years) with 45 males and 17 females; 37 right and 27 left hips. Duration of symptoms prior to arthroscopy averaged 28 months (range 6-168 months). The average improvement was 22 points (pre-op 63; post-op 85) using the 100-point modified Harris hip score and was statistically significant (P ulnar nerve neurapraxia and superficial sensory dysesthesias of the foot, both of which resolved within a few days. This is a heterogeneous cohort of pathology, but illustrates that hip disorders may exist among active duty military personnel and may benefit from arthroscopic intervention. A sense of awareness is important for accurate diagnosis and timely treatment. PMID:27026823

  5. Using Intelligent Techniques in Construction Project Cost Estimation: 10-Year Survey

    Abdelrahman Osman Elfaki

    2014-01-01

    Full Text Available Cost estimation is the most important preliminary process in any construction project. Therefore, construction cost estimation has the lion’s share of the research effort in construction management. In this paper, we have analysed and studied proposals for construction cost estimation for the last 10 years. To implement this survey, we have proposed and applied a methodology that consists of two parts. The first part concerns data collection, for which we have chosen special journals as sources for the surveyed proposals. The second part concerns the analysis of the proposals. To analyse each proposal, the following four questions have been set. Which intelligent technique is used? How have data been collected? How are the results validated? And which construction cost estimation factors have been used? From the results of this survey, two main contributions have been produced. The first contribution is the defining of the research gap in this area, which has not been fully covered by previous proposals of construction cost estimation. The second contribution of this survey is the proposal and highlighting of future directions for forthcoming proposals, aimed ultimately at finding the optimal construction cost estimation. Moreover, we consider the second part of our methodology as one of our contributions in this paper. This methodology has been proposed as a standard benchmark for construction cost estimation proposals.

  6. Discharge against medical advice from Neonatal Intensive Care Unit: 10 years experience at a University Hospital

    Hatim K Al-Turkistani

    2013-01-01

    Full Text Available Background: Discharging patients against medical advice is a problem of every age-group. However, because of their physiological vulnerability, the risk for the neonatal population is greater when discharged against medical advice (DAMA. This article is a study of the prevalence of the problem, the possible causes and/or risk factors. Materials and Methods: A retrospective review of 10 years of medical records of neonates discharged against medical advice from a Neonatal Intensive Care Unit (NICU at a university hospital. Results: The overall prevalence of DAMA was 1.6%. Most of the 51 infants who were taken out of hospital against medical advice (AMA were term (72.5% with a mean gestational age of 37.78 ± 2.5 weeks, of normal birth weight, with a mean of 2736 ± 661 g, Saudis (96%, those delivered vaginally (69%, and those that were provisionally diagnosed with transient tachypnea of newborn (TTN and/or query sepsis (49%. There was no difference between males and females (M/F = 1.2. There was an association between DAMA and the timing of DAMA (27.5% of DAMA at weekends and 67% of DAMA from May to October. Conclusion: DAMA of neonates is particularly critical. The causes and risk factors are many and difficult to predict. In addition to several other factors, its prevalence is influenced negatively by some socio-cultural beliefs.

  7. Keratin Durability Has Implications for the Fossil Record: Results from a 10 Year Feather Degradation Experiment.

    Alison E Moyer

    Full Text Available Keratinous 'soft tissue' structures (i.e. epidermally derived and originally non-biomineralized, include feathers, skin, claws, beaks, and hair. Despite their relatively common occurrence in the fossil record (second only to bone and teeth, few studies have addressed natural degradation processes that must occur in all organic material, including those keratinous structures that are incorporated into the rock record as fossils. Because feathers have high preservation potential and strong phylogenetic signal, in the current study we examine feathers subjected to different burial environments for a duration of ~10 years, using transmission electron microscopy (TEM and in situ immunofluorescence (IF. We use morphology and persistence of specific immunoreactivity as indicators of preservation at the molecular and microstructural levels. We show that feather keratin is durable, demonstrates structural and microstructural integrity, and retains epitopes suitable for specific antibody recognition in even the harshest conditions. These data support the hypothesis that keratin antibody reactivity can be used to identify the nature and composition of epidermal structures in the rock record, and to address evolutionary questions by distinguishing between alpha- (widely distributed and beta- (limited to sauropsids keratin.

  8. Antimetropia in a 10-year-old boy with unilateral tilted disc syndrome

    Makino S

    2014-05-01

    Full Text Available Shinji MakinoDepartment of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, JapanAbstract: Antimetropia is a condition in which one eye is myopic, while the fellow eye is hyperopic. This report describes a case of antimetropia associated with unilateral tilted disc syndrome. A 10-year-old boy presented with the complaint of diminished vision for distant objects in his right eye for several months. His uncorrected distance visual acuity was 0.15 in the right eye and 1.0 in the left eye. Best corrected visual acuity was 1.0, with -6.00 D/-2.00 D 170° in the right eye and +1.50 D in the left eye. The cover test revealed right esotropia and hypertropia. Bifoveal fixation was achieved using a 14 prism diopter (PD base at 220° in the right eye. Fundus examination revealed a tilted disc with inferior staphyloma in the right eye, but no abnormal findings were observed in the left eye. In addition, the patient occasionally experienced diplopia under casual viewing conditions. A cycloplegic refraction revealed -6.00 D/-2.00 D 170° in the right eye and +1.50 D/-2.00 D 5° in the left eye. Thus, prism glasses were prescribed. While wearing the prism glasses, the patient has shown no diplopia and maintains good binocular function.Keywords: amblyopia, strabismus, anisometropia, staphyloma

  9. Some certainties among the many questions of the last 10 years about the primate genome

    In 2000 the first draft of the human genome, what became known as our book of life, was presented. It generated high expectations for its potential applications to the benefit of the biological sciences. What happened 10 years later? We know how many genes we have in our genome and analyzed the function of some of them. Nowadays, we know the sequences of 3 mammalians genomes: M. musculus, P. troglodytes y S. scrofa and the genomes or borradores from other eucaryotes (other animals, plants, fungi and protists) and procaryotes (Archea and Bacterias). However, the study of the genome is not merely a description of the sequences that compose it. The answers provided will have very different approaches from evolution and conservation of biodiversity to gene therapy and malignant transformation, where the study of individual and population particularities requires sources of information both past and present on these genomes under survey. Thus, advances in science are always provisional and therefore liable to be continued, completed and even reinterpreted as we advance in knowledge, new questions arise.

  10. Prevalence of red-green color vision deficiency (cvd among science students: a 10 years' survey

    Arun V. Panat , M.Sc. M.Phil.

    2016-02-01

    Full Text Available Red-green Color vision deficiency (CVD has a high prevalence and is often a handicap in everyday life. The fact that most of the students do not know they have CVD due to non testing of color vision. All Science faculty students of the ASC Rahuri College in the age range of 17-19 were screened for Red-green CVD by using Ishihara test plates from 2001 to 2010. Thus total 654 males and 292 female students were screened during 10 years. The collected data were analyzed for frequency estimation among males and females and then estimating mating types by using the Hardy-Weinberg Principle. Frequency of color blindness in males was 0.303 and that in females 0.288. Predicted mating types show a higher contribution of carrier females, and homozygous color blinds than expected. Estimated normal mating type is only 35.35%. Prevalence of Red-green CVD was found considerably high among science students and specifically among females which is unusual. Mating types involving carrier females, colorblind females, and colorblind males together show a very high contribution than normal ones.

  11. Conference Experience for Undergraduates in the Division of Nuclear Physics - 10 Years Running

    Rogers, Warren

    2008-04-01

    The Conference Experience for Undergraduates (CEU), held annually in the APS Division of Nuclear Physics since 1998, has become a valuable addition to the fall DNP meetings. Since its inception 10 years ago, approximately 730 undergraduate students from over 60 colleges and universities from around the country (and a few from abroad) have participated. The goal of the program is to provide students who have conducted undergraduate research in nuclear science a ``capstone'' conference experience, with the goal toward strengthening retention of talented students in the field. In addition to the main conference, the CEU includes extra activities for the students, including the main research poster session, two undergraduate nuclear physics seminars, and a graduate school information session. CEU application materials are considered by an independent review committee, and travel and lodging grants are awarded based on project merit. Financial support is provided by the NSF, DOE, and DNP. At the recent 10^th anniversary CEU, a mini-symposium was organized as part of the DNP conference, at which former CEU students (now graduate students, post-docs, and professors) had opportunity to talk about their research and the influence that undergraduate research and conference participation had on their career paths. Survey and anecdotal data indicating benefits of CEU participation, as well as initial results from career path tracking will be presented.

  12. PLANT POISONING IN THAILAND: A 10-YEAR ANALYSIS FROM RAMATHIBODI POISON CENTER.

    Sriapha, Charuwan; Tongpoo, Achara; Wongvisavakorn, Sunun; Rittilert, Panee; Trakulsrichai, Satariya; Srisuma, Sahaphume; Wananukul, Winai

    2015-11-01

    Plant poisoning is not uncommon in Thailand. The objective of this study was to determine the incidence, type, clinical manifestations, severity and outcomes of plant poisoned patients in Thailand over a 10-year period. We retrospectively reviewed data from the Ramathibodi Poison Center Toxic Exposure Surveillance System for 2001-2010. A total of 2,901 poisonous plant exposure cases were identified, comprising 3.1% of the 92,392 poison cases recorded during the study period. This was the fifth most common type of poisoning recorded. Children aged poisonous plants were recorded as the causative agents among 99.1%of the cases. Gastrointestinal symptoms were reported in 72.0% of cases with Jatropha curcas (physic nut) comprising 54.1% of these. Most patients had only minor signs and symptoms. The mortality rate among the total plant poisoning cases was 0.9%, with 26 deaths. Thirteen deaths occurred in children aged plant poisoning in Thailand; mostly unintentional. Most cases were minor and the mortality rate was low. Jatropha curcas was the most common cause of poisoning and Manihot esculenta was the most common cause of death. Public education is important to minimize these poisonings. PMID:26867365

  13. Successful removal and reimplant of vagal nerve stimulator device after 10 years

    Marco Giulioni

    2012-01-01

    Full Text Available The number of implanted vagal nerve stimulators is growing and the need for removal or revision of the devices will become even more frequent. A significant concern about Vagus Nerve Stimulation (VNS therapy is the presence of the spiral stimulating electrodes, wrapped around the nerve, once treatment is considered ineffective or is no longer desired. Our purpose is to demonstrate the feasibility of complete removal and replacement of the vagal nerve stimulator electrodes using microsurgical technique even after a long period, without damaging the nerve. We attempted removal and replacement of spiral stimulating electrodes from a patient who received a 10-year long VNS therapy for drug-resistant epilepsy. Our results indicate that the spiral electrodes may be safely removed from the vagus nerve, even after several years. The reversibility of lead implantation may enhance the attractiveness of VNS therapy. Furthermore, with a correct microsurgical technique, it is possible to respect the normal anatomy and functionality of vagal nerve and to reimplant a new VNS system with all its components, maintaining the same therapeutic efficacy after many years.

  14. Mortality in perforated duodenal ulcer depends upon pre-operative risk: a retrospective 10-year study.

    Larkin, J O

    2012-01-31

    INTRODUCTION: Most patients presenting with acutely perforated duodenal ulcer undergo operation, but conservative treatment may be indicated when an ulcer has spontaneously sealed with minimal\\/localised peritoneal irritation or when the patient\\'s premorbid performance status is poor. We retrospectively reviewed our experience with operative and conservative management of perforated duodenal ulcers over a 10-year period and analysed outcome according to American Society of Anesthesiologists (ASA) score. METHODS: The records of all patients presenting with perforated duodenal ulcer to the Department of Surgery, Mayo General Hospital, between January 1998 and December 2007 were reviewed. Age, gender, co-morbidity, ASA-score, clinical presentation, mode of management, operative procedures, morbidity and mortality were considered. RESULTS: Of 76 patients included, 48 (44 operative, 4 conservative) were ASA I-III, with no mortality irrespective of treatment. Amongst 28 patients with ASA-score IV\\/V, mortality was 54.5% (6\\/11) following operative management and 52.9% (9\\/17) with conservative management. CONCLUSION: In patients with a perforated duodenal ulcer and ASA-score I-III, postoperative outcome is uniformly favourable. We recommend these patients have repair with peritoneal lavage performed, routinely followed postoperatively by empirical triple therapy. Given that mortality is equivalent between ASA IV\\/V patients whether managed operatively or conservatively, we suggest that both management options are equally justifiable.

  15. Retinopathy of Prematurity: An Evaluation in the Keelung Area of Taiwan over A 10- Year Period.

    Ko-Jen Yang

    2005-01-01

    Full Text Available Background: We report on the experience of retinopathy of prematurity (ROP at ChangGang Memorial Hospital (CGMH, Keelung, Taiwan over a 10-year period.Methods: A retrospective review was made of data of all premature infants with a diagnosisof ROP at Keelung CGMH between 1994 and 2003. Data on certaincharacteristics including gender, gestational age (GA, birth body weight(BBW, stage of ROP, and treatment modalities were collected and analyzed.Results: Among the 458 infants screened for ROP, 148 eyes of 74 premature infantswere diagnosed as having ROP. Threshold ROP occurred in 24 eyes of 12infants. The average BBW and GA were significantly lower in the thresholdthan in the non-threshold ROP group (p < 0.05. According to medicalrecords of the 24 eyes of the 12 patients receiving transscleral cryotherapy,anatomical success was attained in 13 (81.3% of 16 eyes.Conclusions: This review found low GA and BBW to be major risk factors for ROP. Thisreview shows that transscleral cryotherapy for treating threshold ROPachieved anatomical success in about 80% of eyes. However, myopia,amblyopia, and strabismus remain major sequelae. Laser therapy is nowbelieved to be less damaging to ocular structures and just as effective ascryotherapy in treating ROP.

  16. Desenvolvimento de Questionário de Frequência Alimentar para adultos em amostra de base populacional de Cuiabá, Região Centro-Oeste do Brasil Development of a Food Frequency Questionnaire for adults in a population-based sample in Cuiabá, Mid-Western Region of Brazil

    Márcia Gonçalves Ferreira

    2010-09-01

    Full Text Available OBJETIVO: Descrever a construção de um Questionário de Frequência Alimentar (QFA para utilização em estudos que visem à obtenção de dados sobre o consumo alimentar de adultos de Cuiabá, MT. MÉTODOS: Um inquérito recordatório de 24 horas (R24h foi aplicado em uma subamostra de 104 indivíduos, de ambos os sexos, selecionados aleatoriamente a partir de uma amostra probabilística de estudo de base populacional. Considerando-se frequência de citação e contribuição para o consumo de energia e nutrientes dos alimentos citados nos R24h foram selecionados 81 itens alimentares e as respectivas porções de referência, que foram aquelas mais frequentemente relatadas nos R24h. A lista do QFA foi gerada com oito categorias de resposta para a frequência de consumo. RESULTADOS: Os itens alimentares citados por mais de 50% da amostra foram o açúcar, café, feijão, arroz, carne, pão e refrigerante, sendo que os quatro últimos também foram os que mais contribuíram para o consumo energético. Não se observaram diferenças entre homens e mulheres nos alimentos que mais contribuíram para a ingestão de macro e micronutrientes. CONCLUSÃO: O QFA foi desenvolvido com a inclusão dos itens alimentares de maior relevância para a dieta da população adulta de Cuiabá, Mato Grosso. Comprovadas sua validade e reprodutibilidade, este instrumento será útil em investigações epidemiológicas e clínicas sobre o possível papel da dieta no desenvolvimento de enfermidades nessa população.OBJECTIVE: To describe the design of a Food Frequency Questionnaire (FFQ to be used in studies on food intake of adults from Cuiabá, Mato Grosso State, Brazil. METHODS: A 24-hour dietary recall (24hR was applied to a sub-sample of 104 men and women, randomly selected from a random population-based study sample. Based on the frequency of report and on the contribution to the intake of energy and nutrients in the 24hR, 81 food items and respective reference

  17. Personnel training experience in the radioactive waste management: 10 years of Moscow SIA 'RADON' international education training centre

    Available in abstract form only. Full text of publication follows: The education service for specialists dealing with radioactive waste was established in Russia (former USSR) in 1983 and was based on the capabilities of two organisations: the Moscow Scientific and Industrial Association 'Radon' (SIA 'Radon') and the Chemical Department of Lomonosov's Moscow State University. These two organizations are able to offer training programs in the science fundamentals, applied research and in practical operational areas of the all pre-disposal activities of the radioactive waste management. Since 1997 this system was upgraded to the international level and now acts as International Education Training Centre (IETC) at SIA 'Radon' under the guidance of the IAEA. During 10 years more than 300 specialists from 26 European and Asian countries enhanced their knowledge and skills in radioactive waste management. The IAEA supported specialized regional training courses and workshops, fellowships, on-the-job training, and scientific visits are additional means to assure development of personnel capabilities. Efficiency of training was carefully analysed using the structural adaptation of educational process as well as factors, which have influence on education quality. Social-psychological aspects were also taken into account in assessing the overall efficiency. The analysis of the effect of individual factors and the efficiency of education activity were carried out based on attestation results and questioning attendees. A number of analytical methods were utilised such as Ishikawa's diagram method and Pareto's principle for improving of training programs and activities. (authors)

  18. High Nasopharyngeal Carriage of Non-Vaccine Serotypes in Western Australian Aboriginal People Following 10 Years of Pneumococcal Conjugate Vaccination

    Bowman, Jacinta; Jones, Jade; Stemberger, Natalie A.; Richmond, Peter C.; Leach, Amanda J.; Lehmann, Deborah

    2013-01-01

    Background Invasive pneumococcal disease (IPD) continues to occur at high rates among Australian Aboriginal people. The seven-valent pneumococcal conjugate vaccine (7vPCV) was given in a 2-4-6-month schedule from 2001, with a 23-valent pneumococcal polysaccharide vaccine (23vPPV) booster at 18 months, and replaced with 13vPCV in July 2011. Since carriage surveillance can supplement IPD surveillance, we have monitored pneumococcal carriage in western Australia (WA) since 2008 to assess the impact of the 10-year 7vPCV program. Methods We collected 1,500 nasopharyngeal specimens from Aboriginal people living in varied regions of WA from August 2008 until June 2011. Specimens were cultured on selective media. Pneumococcal isolates were serotyped by the quellung reaction. Results Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were carried by 71.9%, 63.2% and 63.3% respectively of children Aboriginal Australian children, 7vPCV serotypes account for a small proportion of carried pneumococci. A large proportion of circulating serotypes are not covered by any currently licensed vaccine. PMID:24349245

  19. Changes in Active Commuting to School in Czech Adolescents in Different Types of Built Environment across a 10-Year Period.

    Dygrýn, Jan; Mitáš, Josef; Gába, Aleš; Rubín, Lukáš; Frömel, Karel

    2015-10-01

    Active commuting (AC) to school represents a great opportunity to incorporate walking or cycling into adolescents' everyday routine. The objective of the study was to describe changes in AC in Czech adolescents across a 10-year period in different built environments. Data from the 2001 and 2011 Czech Census of Population and Housing were used to examine the mode of transportation taken to school in 6236 adolescents. Changes in AC over time were analyzed for low and high walkable areas separately in two Czech regional cities, Olomouc and Hradec Králové. Between 2001 and 2011, the proportion of adolescents actively commuting to school decreased by 47%, from an absolute rate of 49.1% to 26%. The proportion of active commuters fell in low walkable areas by 61% and in high walkable areas by 39%. The results indicated that adolescents in 2011 were 2.7 times less (OR = 0.365, p actively commute than in 2001. The AC behavior in Czech adolescents has a negative tendency to replicate travel-to-school patterns in adolescents previously described in more developed countries. The findings might serve as a recommendation for municipal policy. PMID:26501304

  20. Changes in Active Commuting to School in Czech Adolescents in Different Types of Built Environment across a 10-Year Period

    Jan Dygrýn

    2015-10-01

    Full Text Available Active commuting (AC to school represents a great opportunity to incorporate walking or cycling into adolescents’ everyday routine. The objective of the study was to describe changes in AC in Czech adolescents across a 10-year period in different built environments. Data from the 2001 and 2011 Czech Census of Population and Housing were used to examine the mode of transportation taken to school in 6236 adolescents. Changes in AC over time were analyzed for low and high walkable areas separately in two Czech regional cities, Olomouc and Hradec Králové. Between 2001 and 2011, the proportion of adolescents actively commuting to school decreased by 47%, from an absolute rate of 49.1% to 26%. The proportion of active commuters fell in low walkable areas by 61% and in high walkable areas by 39%. The results indicated that adolescents in 2011 were 2.7 times less (OR = 0.365, p < 0.001 likely to actively commute than in 2001. The AC behavior in Czech adolescents has a negative tendency to replicate travel-to-school patterns in adolescents previously described in more developed countries. The findings might serve as a recommendation for municipal policy.

  1. Preventable trauma deaths: from panel review to population based-studies

    Vesconi Sergio

    2006-04-01

    Full Text Available Abstract Preventable trauma deaths are defined as deaths which could be avoided if optimal care has been delivered. Studies on preventable trauma deaths have been accomplished initially with panel reviews of pre-hospital and hospital charts. However, several investigators questioned the reliability and validity of this method because of low reproducibility of implicit judgments when they are made by different experts. Nevertheless, number of studies were published all around the world and ultimately gained some credibility, particularly in regions where comparisons were made before and after trauma system implementation with a resultant fall in mortality. During the last decade of century the method of comparing observed survival with probability of survival calculated from large trauma registries has obtained popularity. Preventable trauma deaths were identified as deaths occurred notwithstanding a high calculated probability of survival. In recent years, preventable trauma deaths studies have been replaced by population-based studies, which use databases representative of overall population, therefore with high epidemiologic value. These databases contain readily available information which carry out the advantage of objectivity and large numbers. Nowadays, population-based researches provide the strongest evidence regarding the effectiveness of trauma systems and trauma centers on patient outcomes.

  2. Prevalence and Predictors of Self-Reported Sexual Abuse in Severely Obese Patients in a Population-Based Bariatric Program

    Gabert, Danielle L.; Majumdar, Sumit R; Sharma, Arya M; Rueda-Clausen, Christian F; Klarenbach, Scott W.; Birch, Daniel W; Shahzeer Karmali; Linda McCargar; Konrad Fassbender; Padwal, Raj S

    2013-01-01

    Background. Sexual abuse may be associated with poorer weight loss outcomes following bariatric treatment. Identifying predictors of abuse would enable focused screening and may increase weight management success. Methods. We analyzed data from 500 consecutively recruited obese subjects from a population-based, regional bariatric program. The prevalence of self-reported sexual abuse was ascertained using a single interview question. Health status was measured using a visual analogue scale (VA...

  3. Population-based study of acquired cerebellar ataxia in Al-Kharga district, New Valley, Egypt

    Farghaly WMA

    2011-04-01

    Full Text Available Wafaa MA Farghaly1, Hamdy N El-Tallawy1, Ghaydaa A Shehata1, Tarek A Rageh1, Nabil Abdel Hakeem2, Noha M Abo-Elfetoh11Department of Neurology and Psychiatry, Assiut University, Assiut, Egypt; 2Al Azhar University, Assiut Branch, EgyptBackground: The aim of this research was to determine the prevalence and etiology of acquired ataxia in Al-Kharga district, New Valley, Egypt.Methods: A population-based study of acquired ataxia was conducted in a defined geographical region with a total population of 62,583. A door-to-door survey was used to identify cases of acquired cerebellar ataxia. Patients with acquired cerebellar ataxia at any age and of both genders were included. Cases of known inherited cerebellar ataxia, acquired neurological disorders with ataxia as a minor feature, or pure acquired sensory ataxia, were excluded.Results: We identified 17 cases of acquired ataxia, of which eight were vascular, six were an ataxic cerebral palsy subtype, and three involved postencephalitic ataxia. The crude prevalence rate for acquired ataxia was 27.16/100,000 (95% confidence interval [CI]: 14.3–40.1. The mean age of the patients at interview was 31.8 (range 4–72 years, with a male to female ratio of 2.1:1. The most frequent presenting complaint was disturbance of gait (90.7%. The majority (92% were ambulatory, but only 9.3% were independently self-caring.Conclusion: This population-based study provides an insight into acquired cerebellar ataxia within a defined region, and may inform decisions about the rational use of health care resources for patients with acquired cerebellar ataxia. The most common causes of acquired cerebellar ataxia in this region were cerebrovascular injury and cerebral palsy.Keywords: acquired cerebellar ataxia, prevalence, subtypes, Egypt

  4. Consequences of Chernobyl accident for Poland: Retrospective assessment after 10 years

    The regional contamination in Poland after Chernobyl accident has been presented. On this base the biological and medical consequences have been discussed. The neonatal mortality as well as cancer frequency for selected regional population in Poland have been analysed during the last decade. 10 figs, 20 tabs

  5. Vacuum-assisted breast biopsy under ultrasonographic guidance: analysis of a 10 year experience

    Lee, Seung Hyun; KIm, Eun Kyung; Kim, Min Jung; Moon, Hee Jung; Yoon, Jung Hyun [Dept. of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2014-12-15

    To determine the indications and the diagnostic accuracy of vacuum-assisted breast biopsy (Vb) under ultrasonographic (US) guidance based on a 10-year period of clinical use. This was a retrospective analysis of 2,920 breast lesions in 2,477 consecutive patients who underwent US-guided Vb between February 2002 and December 2011. The proportions of each indication for Vb were analyzed as well as the trend of its use over divided time periods. Histopathological diagnosis and the malignancy rate of the lesions with Vb were analyzed. A comparison of the pathological diagnosis of Vb and the gold standard diagnosis revealed the false negative rate, the underestimation rate, and the agreement rate. Palpable lesions (44.4%), low-suspicion lesions (15.7%), high-risk lesions (12.4%), and calcifications (10.3%) were the most common indications for US-guided Vb. The malignancy rate of lesions submitted to Vb was 5.4%. The false negative rate was only 0.1%, while the underestimation rate of high-risk lesions and ductal carcinoma in situ was 3.1% and 13.8%, respectively, with a 98.7% agreement rate. Among 1,512 therapeutic Vb cases, 84.9% showed no residual or recurrent lesions on long term follow-up US for more than a year. Complications occurred in 1% of the patients without need for surgical intervention. US-guided Vb is an accurate and safe method that can help decision-making in the diagnostic process and can be an alternative for excision al surgery in some therapeutic circumstances.

  6. Recommendations for Serogroup B Meningococcal Vaccine for Persons 10 Years and Older.

    2016-09-01

    This policy statement provides recommendations for the prevention of serogroup B meningococcal disease through the use of 2 newly licensed serogroup B meningococcal vaccines: MenB-FHbp (Trumenba; Wyeth Pharmaceuticals, a subsidiary of Pfizer, Philadelphia, PA) and MenB-4C (Bexsero; Novartis Vaccines, Siena, Italy). Both vaccines are approved for use in persons 10 through 25 years of age. MenB-FHbp is licensed as a 2- or 3-dose series, and MenB-4C is licensed as a 2-dose series for all groups. Either vaccine is recommended for routine use in persons 10 years and older who are at increased risk of serogroup B meningococcal disease (category A recommendation). Persons at increased risk of meningococcal serogroup B disease include the following: (1) persons with persistent complement component diseases, including inherited or chronic deficiencies in C3, C5-C9, properdin, factor D, or factor H or persons receiving eculizumab (Soliris; Alexion Pharmaceuticals, Cheshire, CT), a monoclonal antibody that acts as a terminal complement inhibitor by binding C5 and inhibiting cleavage of C5 to C5A; (2) persons with anatomic or functional asplenia, including sickle cell disease; and (3) healthy persons at increased risk because of a serogroup B meningococcal disease outbreak. Both serogroup B meningococcal vaccines have been shown to be safe and immunogenic and are licensed by the US Food and Drug Administration for individuals between the ages of 10 and 25 years. On the basis of epidemiologic and antibody persistence data, the American Academy of Pediatrics agrees with the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention that either vaccine may be administered to healthy adolescents and young adults 16 through 23 years of age (preferred ages are 16 through 18 years) to provide short-term protection against most strains of serogroup B meningococcal disease (category B recommendation). PMID:27573083

  7. Course of depression in a 10-year prospective study: Evidence for qualitatively distinct subgroups.

    Klein, Daniel N; Kotov, Roman

    2016-04-01

    The course of depressive disorders can vary considerable, with some individuals exhibiting a chronic course and poor outcomes, while others have a more episodic course and better outcomes. However, it is unclear whether degree of chronicity is continuous or reflects qualitatively distinct subgroups. Using data from a 5-wave, 10-year, naturalistic study of 127 depressed outpatients, we examined whether depression chronicity lies on a continuum or manifests natural boundaries. Spline regression was used to test 7 continuous and discontinuous models of the relationship between depression during the first follow-up interval and multiple outcomes at subsequent follow-ups. In order to further validate the findings, we also created empirically derived subgroups based on the results of the spline regression analyses and compared them on baseline clinical characteristics and long-term outcomes. There was a clear and consistent discontinuity indicating that for higher levels of chronicity during the first 30-month period, depression was linearly related to outcome; in contrast, for lower levels of chronicity, depression in the initial interval was unrelated to subsequent outcomes. The findings were strikingly consistent across the 4 follow-up evaluations using multiple outcomes and goodness-of-fit indices. In addition, the chronic group-as defined by the first follow-up period-exhibited more baseline chronic depression, anxiety and personality disorders, family history of dysthymia, and childhood adversity, and was more likely to attempt suicide and be hospitalized during follow-up, than the nonchronic group. Results suggest that there are qualitatively distinct classes of patients with more and less chronic depressions, and support the utility of longitudinal course as a means of parsing depression into more homogeneous subgroups. (PsycINFO Database Record PMID:26845258

  8. Retroperitoneal Fibrosis: A Retrospective Clinical Data Analysis of 30 Patients in a 10-year Period

    Hai-Jiang Zhou

    2015-01-01

    Full Text Available Background: Retroperitoneal fibrosis (RPF is an uncommon disease that is characterized by development of fibrosclerotic tissues involving retroperitoneal structures. This study aimed to investigate the clinical features of 30 patients with RPF in a single center in Beijing in a 10-year period. Methods: We retrospectively analyzed clinical data on demographic characteristics, clinical manifestations, laboratory findings, radiological findings, modalities of treatments, outcomes and prognosis of 30 patients with RPF. Patients were treated in Beijing Chao-Yang Hospital between January 2003 and December 2013. Results: The mean age of patients with RPF was 56.7 ± 14.4 years. Twenty-three patients were men and seven patients were women. Acute phase reactants were elevated in most patients. Rheumatic factor was positive in 4/25 (16.0% patients, and antinuclear antibody was positive in 6/22 (27.3% patients. Elevation of IgG4 was observed in 9/22 (40.9% patients. The most common type was I + III (n = 13, followed by I + II + III (n = 12. Five patients undertook an 18 F-fluoro-deoxy-D-glucose positron emission tomography examination and increased uptake was detected in four patients. Eight patients received combination therapy with glucocorticoids and tamoxifen. Surgical intervention treatments included intraureteral double-J stent implantation (n = 26, percutaneous nephrostomy (n = 2, open ureterolysis and intraperitonealization of the ureters (n = 5 and laparoscopic ureterolysis and intraperitonealization of the ureters (n = 5. Three patients underwent hemodialysis because of renal failure. Conclusions: Clinical characteristics of RPF patients in our study are similar to those previously reported. Steroids and immunosuppressive therapy combined with ureterolysis could be a viable choice of treatment for RPF. More prospective, multi-center studies with a longer follow-up are warranted.

  9. Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study

    Antic Tjana

    2011-01-01

    Full Text Available Abstract Background Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma. Methods Allergic rhinitis subjects with no asthma (n = 371 were followed-up for 10 years and routinely examined for asthma diagnosis. In those who developed asthma (n = 152, clinical severity and levels of asthma control were determined. Among these subjects, 74 (48.7% were current smokers, 17 (11.2% former smokers, and 61 (40.1% never smokers. Results When comparing current or past smokers to never smokers they had a higher risk of severe asthma in the univariate analysis, which became non-significant in the multivariate analysis. On the other hand, the categories of pack-years were significantly related to severe asthma in a dose response relationship in both the univariate and multivariate analysis: compared to 0 pack years, those who smoked 1-10 pack-years had an OR(95% CI of 1.47(0.46-4.68, those who smoked 11-20 pack-years had an OR of 2.85(1.09-7.46 and those who smoked more than 20 pack-years had an OR of 5.59(1.44-21.67 to develop more severe asthma. Smokers with asthma were also more likely to have uncontrolled disease. A significant dose-response relationship was observed for pack-years and uncontrolled asthma. Compared to 0 pack years, those who smoked 1-10 pack-years had an OR of 5.51(1.73-17.54 and those who smoked more than 10 pack-years had an OR of 13.38(4.57-39.19 to have uncontrolled asthma. Conclusions The current findings support the hypothesis that cigarette smoking is an important predictor of asthma severity and poor asthma control.

  10. Orbital exenteration: The 10-year Massachusetts Eye and Ear Infirmary experience.

    Nagendran, Sonali T; Lee, N Grace; Fay, Aaron; Lefebvre, Daniel R; Sutula, Francis C; Freitag, Suzanne K

    2016-08-01

    The authors report their experience with orbital exenteration surgery at one academic institution over a 10-year period and review the literature. This retrospective cohort study monitored outcomes of all patients who underwent orbital exenteration surgery at Massachusetts Eye and Ear Infirmary between January 2003 and January 2013. Patients with no follow-up data or survival data were excluded from the study. The main outcome measures were surgical complications, disease status of surgical margins, need for adjuvant treatment, local recurrence, metastases and survival. 23 patients with malignancy and 2 with mucormycosis met inclusion criteria for the study. Surgical procedures included non-lid sparing total exenteration (44%), lid-sparing total exenteration (32%), non-lid sparing partial exenteration (8%) and lid-sparing partial exenteration (16%). 44% underwent additional extra-orbital procedures. Survival rates were 72% at 1 year, 48% at 3 years, and 37% at 5 years. Of patients with malignancies, 48% had clear margins after exenteration. There was no statistically significant difference in survival between patients with negative surgical margins compared to positive margins (p = 0.12). Mortality was highest in patients with melanoma (85.7%) and lowest in patients with non-squamous cell lid malignancies (0%). Our study suggests that the type of disease has a much greater impact on the survival of patients undergoing exenteration surgery than the type of exenteration surgery or the disease status of surgical margins. Patients with non-squamous cell lid malignancies and localized orbital disease have the best prognosis for tumor eradication from this radical and highly disfiguring surgery. PMID:27322708

  11. Future prospect 2012-2025 - How will our business change for the next 10 years -

    Tanaka, Sakae

    2013-04-01

    The purpose of this lecture is to discuss about the "Future". How our business will change in the next 10 years? I believe the key is 3 mega-trends "Sustainability", "Cloud Computing" and "Life Innovation". With the development of social environment, the required business will change, too. The future would be invisible if you shut yourself up in your single industry. It is important to see various business fields horizontally, and recognize various key changes stereoscopically such as demographics, economy, technology, sense of value and lifestyle, when you develop mid-and-long term strategy. "Cloud" is silent, but the revolution of personal computing. It will bring the drastic changes in every industry. It will make "voice" and "moving image" possible to use as the interface to access your computer. Cloud computing will also make the client device more diversified and spread the application range widely. 15 years ago, the term "IT" was equivalent to "personal computer". Recently, it rather means to use smartphone and tablet device. In the next several years, TV and car-navigation system will be connected to broadband and it will become a part of personal computing. The meaning of personal computing is changing essentially year by year. In near future, the universe of computing will expand to the energy, medical and health-care, and agriculture etc. It passed only 20 years since we use "Computer" in a full scale operation. Recently, computer has start understanding our few words and talking in babble like a baby. The history of computing has just started.

  12. Onset Pattern and Long-Term Prognosis in Schizophrenia: 10-Year Longitudinal Follow-Up Study.

    Nobuhisa Kanahara

    Full Text Available Although the duration of untreated psychosis (DUP plays an important role in the short-term prognosis of patients with schizophrenia, their long-term prognosis generally is not determined by DUP alone. It is important to explore how other clinical factors in the early stage are related to DUP and consequent disease courses.A total of 664 patients with untreated psychosis were surveyed for this study. At the first examination, we divided them into the severe positive symptoms cases (SC or the less severe cases (NonSC and compared the prognosis among the two groups after a 10-year follow-up. In all, 113 patients in the SC group and 43 patients in the NonSC group were follow-up completers.Whereas DUP was not different between the two groups, patients with nonacute onset in both groups had significantly longer DUP than those in patients with acute onset. For all clinical measures, there was no difference in prognosis between the two groups or among the four groups classified by mode of onset (MoO and initial severity of positive symptoms. However, the degree of improvement of global assessment of functioning (GAF was significantly smaller in the NonSC-nonacute group than in the SC-acute and SC-nonacute groups.These results suggest that neither DUP nor MoO alone necessarily affects the initial severity of positive symptoms. Moreover, it is possible that patients with low impetus of positive symptoms onset within long DUP experience profound pathologic processes. Therefore, the current study results indicated that long DUP and nonacute onset were related to poor long-term prognosis, regardless of initial positive symptoms.

  13. Pattern of salivary gland tumors in Manipur, India: A 10 year study

    Rajesh Singh Laishram

    2013-01-01

    Full Text Available Background: Salivary gland lesions, especially the neoplastic lesions constitute a highly heterogeneous histopathologic group. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe. Objectives: To document the pattern of various salivary gland tumors in Manipur, a state in North Eastern India. Materials and Methods: This is a 10 years (2002-2011 retrospective study of all salivary gland specimens received at our referral teaching hospital in Manipur, India. All the histopathology slides of salivary gland specimens during the study period were reviewed and clinical details were obtained from the archives. Restaining of slides and fresh sections of tissue blocks were performed whenever required. Data thus collected were analyzed. Results: A total of 104 cases of salivary gland lesions were studied during the study period. Age ranged from 5 years to 78 years with an overall slight female preponderance (M:F = 1:1.08. Parotid (56.65% was the commonest gland involved followed by submandibular gland (31.73%.Neoplastic lesions comprised of 78 (75% cases and non-neoplastic lesions constituted 25% (26 cases. Among the neoplastic lesions, benign lesions (53.85% predominated over malignant lesions (21.15%. Pleomorphic adenoma was the commonest benign neoplastic lesion and mucoepidermoid carcinoma was the commonest malignant tumor. Chronic sialadenitis was the predominant lesion in the non-neoplastic group. Conclusion: The principal site for salivary gland tumors was the parotid gland and pleomorphic adenoma outnumbered all the other tumors. Females are more affected in the malignant group.

  14. The impact of a 10-year audit cycle on blood usage in a district general hospital.

    James, R M; Brown, S; Parapia, L A; Williams, A T

    2001-10-01

    As clinical governance moves from concept to practice, it is emerging as a realistic strategy to promote and improve quality within the National Health Service, as well as satisfying the demand for external accountability. In the context of blood transfusion, the area of responsibility encompasses product liability, as well as efficient use of blood as a resource and transfusion as an appropriate clinical response. Clinical governance may be a modern catch phrase, but the principles it enshrines have long been established within blood transfusion, and in other aspects of haematology. Here, an audit cycle comprising four audits over a 10-year period to monitor the use of cross-matched blood in a large district general hospital is described. Initially, blood use was considered by hospital site, and by the surgical procedure for which it was requested. Later, the scope of the audit was expanded to consider usage by individual consultant. A standard of efficient use of cross-matched blood was taken to be a cross-match to transfusion ratio of committee, who have a key role in co-ordinating and assessing the practice of transfusion within a hospital. In this hospital, audit has been one of the main tools for improving practice, in particular by enabling the implementation and continuous revision of a maximum blood order schedule. Further, as the process of audit has developed, problem areas have been highlighted, and strategies to improve usage have been brought in with encouraging results. The audit is now being expanded again to include a greater focus on usage of cross-matched blood in the nonsurgical setting. PMID:11696230

  15. Estrogen receptor testing and 10-year mortality from breast cancer: A model for determining testing strategy

    Christopher Naugler

    2012-01-01

    Full Text Available Background: The use of adjuvant tamoxifen therapy in the treatment of estrogen receptor (ER expressing breast carcinomas represents a major advance in personalized cancer treatment. Because there is no benefit (and indeed there is increased morbidity and mortality associated with the use of tamoxifen therapy in ER-negative breast cancer, its use is restricted to women with ER expressing cancers. However, correctly classifying cancers as ER positive or negative has been challenging given the high reported false negative test rates for ER expression in surgical specimens. In this paper I model practice recommendations using published information from clinical trials to address the question of whether there is a false negative test rate above which it is more efficacious to forgo ER testing and instead treat all patients with tamoxifen regardless of ER test results. Methods: I used data from randomized clinical trials to model two different hypothetical treatment strategies: (1 the current strategy of treating only ER positive women with tamoxifen and (2 an alternative strategy where all women are treated with tamoxifen regardless of ER test results. The variables used in the model are literature-derived survival rates of the different combinations of ER positivity and treatment with tamoxifen, varying true ER positivity rates and varying false negative ER testing rates. The outcome variable was hypothetical 10-year survival. Results: The model predicted that there will be a range of true ER rates and false negative test rates above which it would be more efficacious to treat all women with breast cancer with tamoxifen and forgo ER testing. This situation occurred with high true positive ER rates and false negative ER test rates in the range of 20-30%. Conclusions: It is hoped that this model will provide an example of the potential importance of diagnostic error on clinical outcomes and furthermore will give an example of how the effect of that

  16. 10 years after rio-concepts on the contribution of chemistry to a sustainable development.

    Eissen, Marco; Metzger, Jürgen O; Schmidt, Eberhard; Schneidewind, Uwe

    2002-02-01

    The principles of the United Nations Conference on Environment and Development (UNCED), held in June 1992 in Rio de Janeiro, and Agenda 21, the comprehensive plan of action for the 21st century, adopted 10 years ago by more than 170 governments, address the pressing problems of today and also aim at preparing the world for the challenges of this century. The conservation and management of resources for development are the main focus of interest, to which the sciences will have to make a considerable contribution. Natural, economic, and social sciences will have to be integrated in order to achieve this aim. In their future programs, the associations of the chemical industries in Europe, Japan, and the USA have explicitly accepted their obligation to foster a sustainable development. In this review we investigate innovations in chemistry exemplarily for such a development with regard to their ecological, economical, and social dimensions from an integrated and interdisciplinary perspective. Since base chemicals are produced in large quantities and important product lines are synthesized from them, their resource-saving production is especially important for a sustainable development. This concept has been shown, amongst others, by the example of the syntheses of propylene oxide and adipic acid. In the long run, renewable resources that are catalytically processed could replace fossil raw materials. Separation methods existing today must be improved considerably to lower material and energy consumption. Chemistry might become the pioneer of an innovative energy technique. The design of chemical products should make possible a sustainable processing and recycling and should prevent their bio-accumulation. Methods and criteria to assess their contribution to a sustainable development are necessary. The time taken to introduce the new more sustainable processes and products has to be diminished by linking their development with operational innovation management and with

  17. Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours

    Aim: To determine the relative incidence of benign and malignant paediatric parotid gland tumours and whether particular presenting symptoms or imaging characteristics were more likely to predict malignancy. Materials and methods: Hospital records were reviewed for all patients <18 years with histopathology-proven parotid neoplasms over the 10 year period from 2003–2013. Infantile haemangiomas and patients with neurofibromatosis type I were excluded. The presenting clinical symptoms for each patient were recorded. All available CT and MRI examinations for these patients were evaluated for tumour imaging characteristics. Results: Seventeen patients (nine boys, eight girls; age range 2–17 years) were identified with neoplastic parotid masses; 11 tumours were malignant (65%) and six were benign (35%). The malignant tumours consisted of three acinic cell carcinomas, two mucoepidermoid carcinomas, one alveolar rhabdomyosarcoma, one poorly differentiated carcinoma, one low-grade adenocarcinoma, and three metastases (two melanoma, one orbital medulloepithelioma). The benign tumours consisted of five pleomorphic adenomas and one schwannoma. Presenting clinical symptoms were similar between benign and malignant tumours. Twelve MRI and six CT examinations were available for review with five patients undergoing both techniques. MRI features commonly identified with malignant tumours included: hypointense T2 signal, restricted diffusion, ill-defined borders, and focal necrosis. Only four of the six tumours imaged at CT were visualized, and of those, the margins were indeterminate in three patients. Conclusion: Paediatric parotid masses are more likely to be malignant than benign. Presenting clinical symptoms and CT are not helpful for distinguishing benign and malignant disease. MRI features such as T2 hypointensity, restricted diffusion, ill-defined borders, and focal necrosis, although not specific, should raise concern for malignancy. - Highlights: • Pediatric parotid

  18. Birth size and physical activity in a cohort of Indian children aged 6-10 years.

    Kehoe, S H; Krishnaveni, G V; Veena, S R; Hill, J C; Osmond, C; Kiran; Coakley, P; Karat, S C; Fall, C H D

    2012-08-01

    There is evidence of a reduction in children's physical activity in India in the last decade. Our objective was to assess whether size and body composition at birth are associated with physical activity in school-aged children. Children from a prospective observational cohort study born in Mysore, South India between 1997 and 1998 (n = 663) had neonatal anthropometric measurements made within 72 h of delivery [weight, mid-upper arm circumference (MUAC), chest, abdomen and head circumference, crown-heel, crown-buttock and leg length, triceps and subscapular skinfolds]. At 6-10 years, children (n = 449) were asked to wear AM7164 or GT1M Actigraph accelerometers for 7 days. Body composition was measured within 6 months of activity monitoring. Arm muscle area at birth and time of activity monitoring was calculated from MUAC and skinfold measurements. Activity outcome measures were: mean accelerometer counts per minute (cpm); counts per day and proportion of time spent in moderate and vigorous activity. The mean (S.D.) number of days with ≥500 min of recorded accelerometer data was 7.0 (1.1). Linear regression models showed no significant associations between any of the neonatal anthropometric measures and the activity variables. Body fat percentage at 7.5 years was negatively associated with all activity variables (B = -4.69, CI: -7.31, -2.07 for mean cpm). In conclusion, this study showed no associations between body size and skinfold thickness at birth and objectively measured physical activity in childhood. PMID:24098836

  19. 10 years with Planet Earth essence in the primary school children drawings

    D'Addezio, Giuliana

    2016-04-01

    "10 years with Planet Earth" is the title of the 2016 INGV calendar for primary schools representing the review of a project conceived as support and complement of 15 years long INGV dissemination activities with schools. We realized 10 calendars together with and for primary schools, every year with a subject related to a World in constant evolution. Earthquakes, volcanic eruptions, tsunami waves, magnetic storms and other phenomena are manifestations of the complexity and dynamicity, which began more than four billion years ago and never halted. Since the Earth originated to the first presence of water, life and oxygen, the Cambrian explosion of species, the domain of dinosaurs, the great extinctions and glaciations, the surface of our planet experiences continents collisions, mountains and oceans formation and life forms emerging and disappearing. Every year we have launched a competition asking children to send drawings on themes chosen to stimulate learning about Earth Sciences and Planet Earth dynamics. We intended to raise awareness on issues as water resources availability, protection against natural disasters and control of environmental degradation. For each competition, we chose the most significant drawings to be included in the yearly calendar about the Earth. The authors of drawings were awarded by scientists, journalists, artists and science communicators and even by a minister. Besides the competitions, these drawings depict their own impressions and reflections, providing an opportunity to illustrate the children's point of view. From drawings and texts arise a great consideration and respect for the Planet, raising hopes that similar initiatives can contribute to increase the knowledge of the Earth and of the fragile human ecosystem in the hearts and minds of future active citizens. The project was made possible thanks to the teachers and to the wonderful students of more than 200 schools that sent about 10,000 drawings that have intrigued

  20. Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar, Tehran

    Fatemeh Safari

    2012-01-01

    Full Text Available Background: Precocious puberty, as early physical development and low final height might lead to psychosocial problems.Objective: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children.Materials and Methods: In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar, Institute of Endocrinology and Metabolism (Hemmat Campus, were examined in a 10 years period of time. Results: Mean age of girls and boys was 7.43±1.4 years and 5.8±2.1 years respectively. Most of the patients fell within the age category of 7-7.9 years old (40.9% for girls and 50% for boys. Patients, concerning etiology of precocious puberty were classified in three categories: 42.6% of patients had central precocious puberty (CPP, including idiopathic CPP (87.5% and neurogenic CPP (12.5%. 23.3% of patients had peripheral precocious puberty (PPP, including congenital adrenal hyperplasia (CAH (42.8%, ovarian cysts (28.4%, McCune-Albright syndrome (14.2% and adrenal carcinoma (14.2%. 34.1% of girls and 25% of boys had normal variant puberty including premature thelarche (57%, premature adrenarche (38% as well as premature menarche (4.7%l. Conclusion: The most common etiology of precocious puberty in girls was idiopathic central precocious puberty and premature thelarche, while in boys they were neurogenic central precocious puberty and CAH. Therefore precocious puberty in girls is usually benign. In boys, CNS anomalies should first be considered in the differential diagnosis of CPP. Therefore brain Magnetic Resonance Imaging (MRI is mandatory in all cases.

  1. A Single-Center 10-Year Experience with Pasireotide in Cushing's Disease: Patients' Characteristics and Outcome.

    Trementino, L; Michetti, G; Angeletti, A; Marcelli, G; Concettoni, C; Cardinaletti, C; Polenta, B; Boscaro, M; Arnaldi, G

    2016-05-01

    Pasireotide is the first pituitary-directed drug approved for treating patients with Cushing's disease (CD). Our 10-year experience with pasireotide in CD is reported here. Twenty patients with de novo, persistent, or recurrent CD after pituitary surgery were treated with pasireotide from December 2003 to December 2014. Twelve patients were treated with pasireotide in randomized trials and 8 patients with pasireotide sc (Signifor(®); Novartis AG, Basel, Switzerland) in clinical practice. The mean treatment duration was 20.5 months (median 9 months; range, 3-72 months). Urinary free cortisol (UFC) levels mean percentage change (± SD) at last follow-up was-40.4% (± 35.1; range, 2-92%; median reduction 33.3%) with a normalization rate of 50% (10/20). Ten patients achieved sustained normalized late night salivary cortisol (LNSC) levels during treatment. LNSC normalization was associated with UFC normalization in 7/10 patients. Serum cortisol and plasma ACTH significantly decreased from baseline to last follow-up. Body weight decrease and blood pressure improvement during pasireotide treatment were independent from UFC response. Glucose profile worsening was observed in all patients except one. The frequency of diabetes mellitus increased from 40% (8/20) at baseline to 85% (17/20) at last follow-up requiring initiation of medical treatment only in 44% of patients. Pasireotide treatment was associated with sustained biochemical and clinical benefit in about 60% of CD patients. Glucose profile alteration is a frequent complication of pasireotide treatment; however, it seems to be easy to manage with diet and lifestyle intervention in almost half of the patients. PMID:27127913

  2. The development of market power in the Polish power generation sector: A 10-year perspective

    The paper examines how and to which extent consolidation in the Polish power generation sector has affected the potential for market power over the last 10 years. Although this sector has been undergoing liberalisation (privatisation, introduction of TPA regulations and competition etc.), the consolidation efforts shown by Polish governments have resulted in a significant increase in concentration of both installed capacity and production. The methodology applied in this study includes typical ex-post structural and behavioural measures employed to estimate potential for market power, namely: concentration ratios (for the largest and the three largest suppliers), the Herfindahl–Hirschman Index, entropy, Supply Margin Assessment, the Residual Supply Index and the Lerner Index. Furthermore, an analysis based on the Gini coefficient was employed to obtain an insight into inequalities. The results of this study show that governmental decisions led to a significant increase in the potential to exercise market power held by key power generation companies. Of key importance was the 2007 consolidation, resulting in an increase in the HHI to 1374 (in terms of installed capacity) and 1945 (in terms of electricity production). This consolidation resulted in the creation of the first Pivotal Supplier in the Polish power generation sector in 2008. - Highlights: ► Market power analysis based on structural and behavioural indices was carried out for the Polish power sector. ► Governmental policy resulted in significant increase in concentration of both installed capacity and generation. ► Increase in the Lerner Index of brown coal-based generation and decrease of the hard coal-based one were observed.

  3. Dietary calcium intake and risk of obesity in school girls aged 8-10 years

    Mehnoosh Samadi

    2012-01-01

    Full Text Available Background: Some studies have demonstrated the role of calcium in reducing body mass index (BMI or fat mass. Though, BMI does not provide very valid information about changes in body fat mass, Fat Mass Index (FMI relates body fat mass to height and allows comparing body fat mass of individuals at different heights. This study investigated the possible association between dietary calcium intake (CI and other nutritional factors and weight status of girls aged 8-10 years. Materials and Methods: In this case-control study, 110 girls aged 8-10 with FMI at or above 7.2 kg/m 2 as cases and 307 girls with FMI less than 7.2 kg/m 2 as controls were recruited through multistage cluster random sampling. FMI at or above 7.2 kg/m 2 was considered as the cutoff point for obesity. Body fat mass was assessed by a stand on bio impedance analyzer. In order to assess CI, participants were asked to complete a validated food frequency questionnaire. Results: Mean and standard deviation of CI in the case group was significantly lower than the control group 649 ± 103 and 951 ± 152 mg/d, respectively ( P < 0.01. After Adjustment for total energy intake, the percentage of energy from fat, carbohydrate and protein in quartiles of physical activity, inverse association between CI and obesity was significant and in the highest quartile of physical activity the association was weaker. By further adjustment for the effect of fruits and vegetable intake inverse association between CI and obesity became weaker but yet was significant. Conclusion: The inverse relationship between CI and FMI remained significant even after controlling for confounding factors. FMI may be more accurate, compared to BMI, in showing the association between CI and obesity.

  4. Male Breast Cancer: 10-Year Experience at Mansoura University Hospital in Egypt

    Male breast cancer (MBC) is a rare disease representing less than 1% of all malignancies. The objective of the study is to report clinicopathological characteristics, treatment patterns, and outcomes of MBC in Mansoura University Hospital, Egypt. This retrospective study focused on male breast cancer patients during 10 years (2000-2009). The studied variables were data regarding general characteristics of patients, treatment modalities and survival. The series included 37 patients (0.8% of all breast cancer). The median age was 57.7 years (range: 26-86 years). The main clinical complaint was a mass beneath the areola in 94.5% of the cases. Most patients had a locally advanced disease. 94.5% of tumors were invasive duct carcinomas. The treatment was essentially surgery in 91.8%, followed by adjuvant radiotherapy (in 89.2%), hormonal therapy (in 56.7%) and chemotherapy (in 91.8%). Follow-up period ranged from 6-115 months. Local recurrence occurred in 4 cases and metastasis in 11 cases. The 2-year and 5-year overall survival (OS) rates were 81.6% and 60.5%, respectively. The 2-year and 5-year disease-free survival (DFS) rates were 68.4%, and 52.6%, respectively. OS was not significantly affected by any of the studied parameters. Factors influencing DFS were: T stage (P=0.05), positive lymph nodes (P=0.043), metastasis (P=0.004), and chemotherapy (P=0.046). MBC is a rare disease and often diagnosed at a locally advanced stage. The management of male and female breast carcinoma is identical. Future research for better understanding of this disease is needed to improve the management and prognosis of male breast cancer patients

  5. Variability and Stability in Daily Moderate-to-Vigorous Physical Activity among 10 Year Old Children

    Sara Pereira

    2015-08-01

    Full Text Available Day-to-day variability and stability of children’s physical activity levels across days of the week are not well understood. Our aims were to examine the day-to-day variability of moderate-to-vigorous physical activity (MVPA, to determine factors influencing the day-to-day variability of MVPA and to estimate stability of MVPA in children. The sample comprises 686 Portuguese children (10 years of age. MVPA was assessed with an accelerometer, and BMI was computed from measured height and weight. Daily changes in MVPA and their correlates (gender, BMI, and maturity were modeled with a multilevel approach, and tracking was calculated using Foulkes & Davies γ. A total of 51.3% of boys and 26.2% of girls achieved 60 min/day of MVPA on average. Daily MVPA was lower during the weekend (23.6% of boys and 13.6% of girls comply with the recommended 60 min/day of MVPA compared to weekdays (60.8% and 35.4%, boys and girls, respectively. Normal weight children were more active than obese children and no effect was found for biological maturation. Tracking is low in both boys (γ = 0.59 ± 0.01 and girls (γ = 0.56 ± 0.01. Children’s MVPA levels during a week are highly unstable. In summary, boys are more active than girls, maturation does not affect their MVPA, and obese children are less likely to meet 60 min/day of MVPA. These results highlight the importance of providing opportunities for increasing children’s daily MVPA on all days of week, especially on the weekend.

  6. Reactivation of intestinal CMV in a renal transplant patient after 10 years from the transplant

    Maria Landi

    2013-04-01

    Full Text Available Introduction.We analyzed the clinical case of a 51 years old man, kidney transplanted on December 2002. On April 2011, he had acute rectal bleeding, renal chronic rejection (creatinine 2.9 mg/dl, Hgb 8.7 g/dl, positive anti-CMV antibodies (IgG. A colonoscopy showed diverticulosis of the rectum associated with deepithelialisation. The patient was treated with maintenance immunosuppressive post-transplant therapy. On June 2011, the colonoscopy showed a stenosing lesion of the sigmoid colon, and blood sampling and intestinal biopsy were performed to search Cytomegalovirus (CMV DNA by PCR. Methods. The presence of CMV-DNA was sought by automatic extractor QIACUBE, using QIAamp DNA BLOOD Mini Kit (Qiagen for whole blood and QIAamp DNA Mini Kit (Qiagen for biopsy.The extracted DNA was then amplified by Real Time PCR using Q-CMV RealTime Complete Kit (Nanogen, on instrument Applied Biosystems 7300. Results. At disease onset the viral load in whole blood was 208000 Geq/ml, and biopsy was positive. Antiviral therapy with Ganciclovir led to the negativity of the viral load and remission of symptoms. Conclusions. The clinical case described presented a reactivation of CMV infection in the intestine after more than 10 years from kidney transplantation, while the highest incidence of CMV reactivation usually occurs during the first year. In our opinion, the reactivation can be traced to long-term immunosuppressive therapy (maintenance posttransplant therapy in combination with a state of inflammation of the intestinal mucosa. In fact, patients with IBD treated with steroid drugs, in particular the group of refractory to therapy and thus have a recovery of the inflammatory process, are exposed to reactivation of CMV with intestinal localization.

  7. Healthcare-associated Pneumonia: Clinical Features and Retrospective Analysis Over 10 Years

    Fei Qi; Guo-Xin Zhang; Dan-Yang She; Zhi-Xin Liang; Ren-Tao Wang; Zhen Yang; Liang-An Chen

    2015-01-01

    Background:Healthcare-associated pneumonia (HCAP) is associated with drug-resistant pathogens and high mortality,and there is no clear evidence that this is due to inappropriate antibiotic therapy.This study was to elucidate the clinical features,pathogens,therapy,and outcomes of HCAP,and to clarify the risk factors for drug-resistant pathogens and prognosis.Methods:Retrospective observational study among hospitalized patients with HCAP over 10 years.The primary outcome was 30-day all-cause hospital mortality after admission.Demographics (age,gender,clinical features,and comorbidities),dates of admission,discharge and/or death,hospitalization costs,microbiological results,chest imaging studies,and CURB-65 were analyzed.Antibiotics,admission to Intensive Care Unit (ICU),mechanical ventilation,and pneumonia prognosis were recorded.Patients were dichotomized based on CURB-65 (low-vs.high-risk).Results:Among 612 patients (mean age of 70.7 years),88.4% had at least one comorbidity.Commonly detected pathogens were Acinetobacter baumannii,Pseudomonas aeruginosa,and coagulase-negative staphylococci.Initial monotherapy with β-lactam antibiotics was the most common initial therapy (50%).Mean age,length of stay,hospitalization expenses,ICU admission,mechanical ventilation use,malignancies,and detection rate for P.aeruginosa,and Staphylococcus aureus were higher in the high-risk group compared with the low-risk group.CURB-65 ≥3,malignancies,and mechanical ventilation were associated with an increased mortality.Logistic regression analysis showed that cerebrovascular diseases and being bedridden were independent risk factors for HCAR.Conclusion:Initial treatment of HCAP with broad-spectrum antibiotics could be an appropriate approach.CURB-65 ≥3,malignancies,and mechanical ventilation may result in an increased mortality.

  8. Ciguatera fish poisoning in Hong Kong--a 10-year perspective on the class of ciguatoxins.

    Wong, Chun-Kwan; Hung, Patricia; Lo, Janice Y C

    2014-08-01

    The present study used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate retrospectively ciguatoxin (CTX)-positive samples as determined by mouse bioassay (MBA) in the past 10 years in Hong Kong. The results showed that Pacific CTXs (P-CTX-1, -2 and -3) were the most commonly observed toxins found in the samples, indicating Pacific Ocean areas as the most important origin of ciguatera fish poisoning. Clinical diagnosis from ciguatera patients also revealed the predominance of neurological illnesses in most cases, supporting intoxication of Pacific origin. This study demonstrated the ability of laboratory analysis to identify and quantify Pacific CTXs in suspected fish samples, so as to support the clinical diagnosis of ciguatera. Comparative analysis (Student's t-test and Spearman's rank correlation analysis) on the two CTX detection methods showed approximate linearity for overall P-CTXs (P-CTX-1, -2 and -3)/P-CTX-1 alone as derived by LC-MS/MS and total toxicity levels (P-CTX-1 equivalent) as determined by MBA. The LC-MS/MS method coupled with the rapid extraction method could allow the detection of trace amount of CTXs at levels below the clinically relevant limit, 0.1 ppb P-CTX-1 in fish flesh. For practical application, the adoption of a two-tiered approach for testing, chemical analysis by LC-MS/MS for toxic fish screening, coupled with biological assay by MBA for final toxicity confirmation, was proposed for first-line screening of CTX in potentially contaminated fish samples in the market, with an aim to minimizing the use of laboratory mice and at the same time providing reasonably effective means for routine analysis. PMID:24878373

  9. The 10-year Trend of Periprocedural Complication Following Carotid Artery Stenting; Single Center Experience

    Hong, Jeong-Ho [Keimyung University Dongsan Medical Center, Department of Neurology (Korea, Republic of); Kang, Jihoon; Yeo, Min-Ju; Kim, Beom Joon; Jang, Min Uk; Bae, Hee-Joon [Seoul National University College of Medicine, Department of Neurology, Stroke Center, Seoul National University Bundang Hospital (Korea, Republic of); Kwon, O-Ki; Hwang, Gyo Jun; Oh, Chang Wan [Seoul National University Bundang Hospital, Department of Neurosurgery (Korea, Republic of); Jung, Cheolkyu [Seoul National University Bundang Hospital, Department of Radiology (Korea, Republic of); Lee, Ji Sung [Soonchunhyang University Medical Center, Biostatistical Consulting Unit (Korea, Republic of); Han, Moon-Ku, E-mail: mkhan@snu.ac.kr [Seoul National University College of Medicine, Department of Neurology, Stroke Center, Seoul National University Bundang Hospital (Korea, Republic of)

    2015-04-15

    PurposeCarotid endarterectomy and stenting are used to treat carotid stenosis, with the volume of carotid artery procedures increasing over the past decade. We investigated the 10-year trend of periprocedural complications with an increasing procedure volume of carotid stenting at a single tertiary hospital.MethodsWe collected 416 consecutive cases (384 patients) of carotid artery stenting performed for either symptomatic (231 cases, 55.5 %) or asymptomatic (185 cases, 44.5 %) internal carotid artery stenosis at a single center. Periprocedural complication was defined as any stroke, myocardial infarction, or death. Procedure-related outcome included any dissection, hemodynamic event, or periprocedural complication.ResultsThe mean age was 68.8 years (82.8 % males; range of 20–89 years); 23.9 % were older than 75 years. Before the procedure, 99.3 and 56.0 % of patients received antiplatelet and lipid-lowering medication, respectively. The overall periprocedural complication rate was 3.6 % (1.6 and 5.2 % in the asymptomatic and symptomatic group, respectively). The composite outcome of any stroke or death was 3.4 %. Periprocedural complication and procedure-related outcome showed a decremental trend with increasing procedure volume, and this trend remained after adjusting for confounders.ConclusionsOur study suggests that carotid stenting at an experienced center might reduce the periprocedural complications. Our periprocedural complication rate of carotid artery stenting may be comparable to, or somewhat lower than, that reported in other clinical trials.

  10. Microbial profile of the vitreous aspirates in culture proven exogenous endophthalmitis: A 10-year retrospective study

    H Bhattacharjee

    2016-01-01

    Full Text Available Purpose: To describe the microbiological profile and clinical outcome in the eyes with culture-proven exogenous endophthalmitis. Methods: A retrospective analysis of 495 eyes diagnosed as exogenous endophthalmitis was performed over a period of 10 years. In all, aseptically collected aqueous and vitreous aspirates were cultured for bacteria and fungus using standard microbiological techniques. Gram-stain and KOH preparation of the specimens were also performed. The antibiotic susceptibility testing for bacterial isolates was performed by Kirby-Bauer disk diffusion method. The treatment was modified according to the antibiotic sensitivity profile. The final clinical ocular condition was divided into improved, stable or deteriorated. Results: Of 148 culture-proven endophthalmitis eyes, 137 (92.57% were referred from elsewhere, and 11 (7.43% belonged to our institute. Aetiologically, 76 (51.35% eyes were post-cataract surgery, 61 (41.22% were post-traumatic, 5 (3.38% eyes post-intravitreal anti-vascular endothelial growth factor injection, 5 associated with corneal diseases and 1 bleb-related endophthalmitis. In 31 (20.95% eyes, primary intravitreal antibiotics were given outside. The cultures revealed monomicrobial growth in 92.57% (n = 137 and polymicrobial growth in 7.43% (n = 11. Among the bacteria (n = 121, 81.76%, Pseudomonas species dominated overall (n = 32, 27.11% and post-operative (n = 26, 38.23% endophthalmitis group. Staphylococcus epidermidis (n = 14, 28% was prominent in post-traumatic endophthalmitis group. Ninety-two percent (n = 108 isolates of bacteria were sensitive to vancomycin. In 78 (52.7% eyes, the clinical ocular condition improved or remained stable while deteriorated in 51 (34.46%. Conclusion: A bacterial predominance was observed among causative organisms of exogenous endophthalmitis with Pseudomonas species being the most common. The appropriate surgical intervention improved or stabilised the visual acuity in nearly

  11. Provider communication on perinatal depression: a population-based study.

    Farr, Sherry L; Ko, Jean Y; Burley, Kim; Gupta, Seema

    2016-02-01

    Women's lack of knowledge on symptoms of perinatal depression and treatment resources is a barrier to receiving care. We sought to estimate the prevalence and predictors of discussing depression with a prenatal care provider. We used the 2011 population-based data from 24 sites participating in the Pregnancy Risk Assessment Monitoring System (n = 32,827 women with recent live births) to examine associations between maternal characteristics and report that a prenatal care provider discussed with her what to do if feeling depressed during or after pregnancy. Overall, 71.9 % of women reported discussing perinatal depression with their prenatal care provider (range 60.7 % in New York City to 85.6 % in Maine). Women were more likely to report a discussion on perinatal depression with their provider if they they were 18-29 years of age than over 35 years of age compared to older (adjusted prevalence ratio [aPR] 18 to 19 y = 1.08, 20 to 24 y = 1.10, 25 to 29 y = 1.09), unmarried (aPR = 1.07) compared to married, had 12 years, and had no previous live births (aPR = 1.03) compared to ≥ 1 live births. Research is needed on effective ways to educate women about perinatal depression and whether increased knowledge on perinatal depression results in higher rates of treatment and shorter duration of symptoms. PMID:25578631

  12. Smoking, Antioxidant Supplementation and Dietary Intakes among Older Adults with Age-Related Macular Degeneration over 10 Years

    Gopinath, Bamini; Flood, Victoria M; Kifley, Annette; Liew, Gerald; Mitchell, Paul

    2015-01-01

    We aimed to compare the micronutrient usage and other lifestyle behaviors over 10 years among those with and without age-related macular degeneration (AMD). 1612 participants aged 49+ years at baseline were re-examined over 10 years, west of Sydney, Australia. AMD was assessed from retinal photographs. Dietary data were collected using a semi-quantitative food frequency questionnaire. Smoking status was self-reported. 56 participants had any AMD at baseline, of these 25% quit smoking at 5 yea...

  13. Panic attacks 10 years after heart transplantation successfully treated with low-dose citalopram: a case report

    Ye, Chenyu; ZHUANG, Yamin; Ji, Jianlin; Chen, Hao

    2015-01-01

    Summary Panic attacks are common among patients who have undergone heart transplantation, but there are no clinical guidelines for the treatment of panic attacks in this group of patients. This report describes a 22-year-old woman who experienced panic attacks 10 years after heart transplant surgery. The attacks started after she discovered that the average post-transplantation survival is 10 years. Treated with citalopram 10 mg/d, her symptoms improved significantly after 2 weeks and had com...

  14. Looking Back, Looking Forward in Stakeholder Engagement. 10-year Anniversary Colloquium of the FSC, 15 September, OECD Conference Centre, Paris

    The OECD Nuclear Energy Agency (NEA) and its Radioactive Waste Management Committee (RWMC) proudly celebrate the 10. anniversary of the Forum on Stakeholder Confidence with a one-day open Colloquium in Paris. The Colloquium takes stock of FSC achievements, conducts a multi-stakeholder discussion of important themes in the governance of radioactive waste management, and gathers guidance on new directions to be taken by the FSC in coming years. The Colloquium welcomes some 80 participants: local and national opinion leaders and stakeholder representatives, government policy and regulatory officials, R and D specialists, implementers and industry representatives from 16 countries, and journalists. This report brings together the presentations (slides) given at this colloquium: 1 - Update since September 2009, The 10-year Anniversary Colloquium; Review of the RWMC and its working parties; Review of countries' input and RWMC project vision (C. Pescatore); 2 - State-of-the-art Report on Marker Systems for Radioactive Waste Repositories (M. Buser); 3 - Consideration of Social Scientific Aspects in a Safety Case for a Geological Repository in Germany, Results of a Research Project (B. Kallenbach-Herbert); 4 - Interplay Among Stakeholders for the Definition of the Detailed Geological Survey Zone in the Meuse/Haute-Marne (Andra); 5 - Regulatory Guidance on Retrievability (D. Brazier); 6 - Sogin engagement process 2010, Focus on involvement of economic operators as a part of the local community (Sogin); 7 - The role of the Government in territorial development of Meuse/Haute-Marne (Andra); 8 - Cooperating with regional elected authorities, some cases in Spain (M. Molina); 9 - Regional development and economic growth (C. Blom); 10 - Seeking transparency, Collective Action... (C. Pescatore); 11 - Introduction and overview of country responses to the transparency questionnaire (E. Simic); 12 - EC initiatives/support towards enhanced transparency and citizens participation

  15. Decreases in human immunodeficiency virus infection rates in Kombolcha, Ethiopia: a 10-year data review

    Shiferaw, Melashu

    2016-01-01

    Melashu Balew Shiferaw,1 Gebremedhin Berhe Gebregergs,2 Mulusew Alemneh Sinishaw,3 Yohannes Amede Yesuf,4 1Laboratory Capacity Building Core Process, Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, Ethiopia; 2Department of Epidemiology, College of Health Sciences, School of Public Health, Mekelle University, Mekelle, Ethiopia; 3Department of Clinical Chemistry, Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, Ethiopia; 4Department of Laboratory, Africa Service...

  16. Epidemiology of Haemophilus influenzae bacteremia: A multi-national population-based assessment

    Laupland, Kevin B; Schønheyder, Henrik C; Østergaard, Christian;

    2011-01-01

    OBJECTIVES: Haemophilus influenzae is an important cause of invasive infection but contemporary data in non-selected populations is limited. METHODS: Population-based surveillance for Haemophilus influenzae bacteremia was conducted in seven regions in Australia, Canada, and Denmark during 2000......-2008. RESULTS: The overall annual incidence rate was 1.31 per 100,000 population and type specific rates were 0.08 for H. influenzae serotype b (Hib), 0.22 for H. influenzae serotypes a, c-f (Hiac-f), and 0.98 per 100,000 for non-typeable H. influenzae (NTHi). Very young and old patients were at highest risk......%. Factors independently associated with death at 30-days in logistic regression analysis included male gender, hospital-onset disease, older age, and lower respiratory tract, central nervous system, or unknown focus of infection. CONCLUSIONS: Haemophilus influenzae is an important cause of morbidity and...

  17. Influence of steel corrosion on Tournemire argillite after 10 years under natural underground context

    Document available in extended abstract form only. Carbon steels are possible materials for high-level radioactive waste canisters used in long term geological disposal in argillaceous environments. The French Institute of Radioprotection and Nuclear Safety (IRSN) conducts, in collaboration with EDF, an experimental program on steel/argillite interactions under natural conditions in its Underground Research Facility in Tournemire (Aveyron, France). Previous studies had investigated the corrosion rate of carbon steel (Foct et al., 2004; Foct, 2006) and modifications of the argillite (Gaudin et al., 2009) after 2 and 6 years of contact. The present study investigates re-compacted argillite/carbon steel interactions far from mechanical disturbances without water flow, after 10 years. A detailed study by X-ray microtomography (Stock, 2009) and autoradiography (Hellmuth et al., 1994) allowed us to characterize the spatial dispersion of Fe and its influence on the evolution of argillite porosity. A significant corrosion of the carbon steel sample and the development of a reddish Fe-rich front within the argillite resulting from an iron diffusion is observed. The formation of iron oxy-hydroxides (goethite, magnetite and hematite) is identified in the altered argillite. Other mineralogical changes are highlighted such as dissolution of calcite, gypsum precipitation and modification of I/S mixed-layers. The Fe distribution within the argillite at the contact appears heterogeneous. Reddish Fe-enriched haloes of maximum 4 mm within the argillite are observed macroscopically (Figure 1a) and by X-ray microtomography. Moreover, autoradiography measurements were performed and changes in porosity are observed from carbon steel to argillite (Figure 1c). The correlation with the microtomography image (Figure 1b) shows that these variations can be associated to iron diffusion areas. On the other hand, a porosity profile shows four distinct areas differing by their mean porosity: (1

  18. Electro interstitial scan system: assessment of 10 years of research and development

    Maarek A

    2012-03-01

    children; and (4 estimation of the morphology of the interstitial fluid (selective serotonin reuptake inhibitor treatment response.Conclusion: After 10 years of development, the analysis of current scientific knowledge and results of clinical investigations have allowed a better understanding of EIS electrical measurements.Keywords: EIS, electro interstitial scan, electrochemical redox reactions, postsympathetic cholinergic electrical stimulation, ADHD, SSRI treatment responses, prostate cancer, diabetes

  19. Scientific literature addressing detection of monosialoganglioside A 10-year bibliometric analysis

    Yanli Xu; Miaojing Li; Zhijun Liu; Aiping Xi; Chaoxian Zhao; Jianzhong Zhang

    2012-01-01

    first with 30 articles, followed by University of Medicine and Dentistry of New Jersey (28 articles), Cornell University (24 articles) and Johns Hopkins University (24 articles). In 442 articles published by Japanese, Nagoya University ranked the first with 40 articles, followed by Kinki University (36 articles), and Dokkyo University (31 articles). Though the total number of publications by Japanese is smaller than Americans, the top three institutions published more publications than American institutions. There is a markedly increase in the number of publications on the subject detection of monosialoganglioside in 2004, which the peak in the past 10 years. The valley bottom of the subject appeared in 2005. In total, the research is increased with time prolonged. Journal of Neurochemistry, Journal of Biological Chemistry and Journal of Neuroimmunology were core subject journals in monosialoganglioside studies. CONCLUSION: This study highlights the topics in detection of monosialoganglioside research that are being published around the world.

  20. The International Space Station and the Space Debris Environment: 10 Years On

    Johnson, Nicholas; Klinkrad, Heiner

    2009-01-01

    For just over a decade the International Space Station (ISS), the most heavily protected vehicle in Earth orbit, has weathered the space debris environment well. Numerous hypervelocity impact features on the surface of ISS caused by small orbital debris and meteoroids have been observed. In addition to typical impacts seen on the large solar arrays, craters have been discovered on windows, hand rails, thermal blankets, radiators, and even a visiting logistics module. None of these impacts have resulted in any degradation of the operation or mission of the ISS. Validating the rate of small particle impacts on the ISS as predicted by space debris environment models is extremely complex. First, the ISS has been an evolving structure, from its original 20 metric tons to nearly 300 metric tons (excluding logistics vehicles) ten years later. Hence, the anticipated space debris impact rate has grown with the increasing size of ISS. Secondly, a comprehensive visual or photographic examination of the complete exterior of ISS has never been accomplished. In fact, most impact features have been discovered serendipitously. Further complications include the estimation of the size of an impacting particle without knowing its mass, velocity, and angle of impact and the effect of shadowing by some ISS components. Inadvertently and deliberately, the ISS has also been the source of space debris. The U.S. Space Surveillance Network officially cataloged 65 debris from ISS from November 1998 to November 2008: from lost cameras, sockets, and tool bags to intentionally discarded equipment and an old space suit. Fortunately, the majority of these objects fall back to Earth quickly with an average orbital lifetime of less than two months and a maximum orbital lifetime of a little more than 15 months. The cumulative total number of debris object-years is almost exactly 10, the equivalent of one piece of debris remaining in orbit for 10 years. An unknown number of debris too small to be

  1. A successful population-based smoking cessation program

    Hovan-Somborac Jaroslava

    2003-01-01

    Full Text Available Introduction Our country is in the third place in Europe concerning tobacco smoking. Although strict law regulations regarding indoor smoking have been brought, the law banning all tobacco advertising, and the behaviour of our population are inadequate. Our objective was to persuade smokers for the 'Quit and Win' campaign and to establish the number of smokers in health personnel employed in health facilities. Material and methods This population-based smoking cessation campaign was coordinated by Federal Institute of Public Health, through a network of Public Health Institutes within the country with the support of national and local media. Results and discussion Quit and Win campaign was organized for the third time. The campaign was realized with the financial support and sponsorship at community level throughout the country. The Federal Ministry provided a national health award. The national and local media accompanied the campaign. The campaign included 3.178 smokers and 2.575 supporters, that is 0.1% of the population over 18 years of age. This is in accordance with participants in some other countries, who had a better support. More than 60% of health care facility employees are smokers. Conclusions Our tradition, habits in the society and overall situation encourage smoking habits to spread in general population. Our campaign has proved that people should be motivated to quit smoking, but they need to be informed. Actions taken in general population and based on a positive smoking cessation program in which smokers are willing to stop smoking have given unexpectedly good results.

  2. Young adults' trajectories of Ecstasy use: a population based study.

    Smirnov, Andrew; Najman, Jake M; Hayatbakhsh, Reza; Plotnikova, Maria; Wells, Helene; Legosz, Margot; Kemp, Robert

    2013-11-01

    Young adults' Ecstasy use trajectories have important implications for individual and population-level consequences of Ecstasy use, but little relevant research has been conducted. This study prospectively examines Ecstasy trajectories in a population-based sample. Data are from the Natural History Study of Drug Use, a retrospective/prospective cohort study conducted in Australia. Population screening identified a probability sample of Ecstasy users aged 19-23 years. Complete data for 30 months of follow-up, comprising 4 time intervals, were available for 297 participants (88.4% of sample). Trajectories were derived using cluster analysis based on recent Ecstasy use at each interval. Trajectory predictors were examined using a generalized ordered logit model and included Ecstasy dependence (World Mental Health Composite International Diagnostic Instrument), psychological distress (Hospital Anxiety Depression Scale), aggression (Young Adult Self Report) and contextual factors (e.g. attendance at electronic/dance music events). Three Ecstasy trajectories were identified (low, intermediate and high use). At its peak, the high-use trajectory involved 1-2 days Ecstasy use per week. Decreasing frequency of use was observed for intermediate and high-use trajectories from 12 months, independently of market factors. Intermediate and high-use trajectory membership was predicted by past Ecstasy consumption (>70 pills) and attendance at electronic/dance music events. High-use trajectory members were unlikely to have used Ecstasy for more than 3 years and tended to report consistently positive subjective effects at baseline. Given the social context and temporal course of Ecstasy use, Ecstasy trajectories might be better understood in terms of instrumental rather than addictive drug use patterns. PMID:23899430

  3. Recurrent Wheezing in Infants: A Population-Based Study.

    Belhassen, Manon; De Blic, Jacques; Laforest, Laurent; Laigle, Valérie; Chanut-Vogel, Céline; Lamezec, Liliane; Brouard, Jacques; Fauroux, Brigitte; de Pouvourville, Gérard; Ginoux, Marine; Van Ganse, Eric

    2016-04-01

    Recurrent wheezing (RW) has a significant impact on infants, caregivers, and society, but morbidity and related medical resource utilization (MRU) have not been thoroughly explored. The burden of RW needs to be documented with population-based data. The objective was to assess the characteristics, medical management, and MRU of RW infants identified from national claims data.Infants aged from 6 to 24 months, receiving ≥2 dispensations of respiratory drugs within 3 months, and presenting a marker of poor control (index date), were selected. During the 6 months after index date, MRU was described in the cohort and among 3 subgroups with more severe RW, defined as ≥4 dispensations of respiratory drugs, ≥3 dispensations of oral corticosteroids (OCS), or ≥1 hospitalization for respiratory symptoms.A total of 115,489 infants had RW, corresponding to 8.2% of subjects in this age group. During follow-up, 68.7% of infants received inhaled corticosteroids, but only 1.8 U (unit) were dispensed over 6 months, suggesting discontinuous use. Control was mostly inadequate: 61.7% of subjects received OCS, 80.2% antibiotics, and 71.2% short-acting beta-agonists, and medical/paramedical visits were numerous, particularly for physiotherapy. Severe RW concerned 39.0% of the cohort; 32.8% and 11.7% of infants had repeated use of respiratory drugs and OCS, respectively, and 5.5% were hospitalized for respiratory symptoms.In this real-life nation-wide study, RW was common and infants had poor control and high MRU. Interventions are needed to support adequate use of controller therapy, and to improve medical care. PMID:27082618

  4. Incidence of anogenital warts in Germany: a population-based cohort study

    Mikolajczyk Rafael T

    2010-12-01

    Full Text Available Abstract Background Human papilloma virus (HPV types 6 and 11 account for 90 percent of anogenital warts (AGW. Assessment of a potential reduction of the incidence of AGW following introduction of HPV vaccines requires population-based incidence rates. The aim of this study was to estimate incidence rates of AGW in Germany, stratified by age, sex, and region. Additionally, the medical practitioner (gynaecologist, dermatologist, urologist etc. who made the initial diagnosis of AGW was assessed. Methods Retrospective cohort study in a population aged 10 to 79 years in a population-based healthcare insurance database. The database included more than 14 million insurance members from all over Germany during the years 2004-2006. A case of AGW was considered incident if a disease-free period of twelve months preceded the diagnosis. To assess regional variation, analyses were performed by federal state. Results The estimated incidence rate was 169.5/100,000 person-years for the German population aged 10 to 79 years. Most cases occurred in the 15 to 40 years age group. The incidence rate was higher and showed a peak at younger ages in females than in males. The highest incidence rates for both sexes were observed in the city-states Berlin, Hamburg and Bremen. In females, initial diagnosis of AGW was most frequently made by a gynaecologist (71.7%, whereas in males, AGW were most frequently diagnosed by a dermatologist (44.8% or urologist (25.1%. Conclusions Incidence of AGW in Germany is comparable with findings for other countries. As expected, most cases occurred in the younger age groups. The frequency of diagnoses of AGW differs between sexes and women and men receive treatment by doctors of different specialties.

  5. Haiti’s progress in achieving its 10-year plan to eliminate cholera: hidden sickness cannot be cured

    Koski-Karell, Victoria; Farmer, Paul E; Isaac, Benito; Campa, Elizabeth M; Viaud, Loune; Namphy, Paul C; Ternier, Ralph; Ivers, Louise C

    2016-01-01

    Since the beginning of the cholera epidemic in Haiti 5 years ago, the prevalence of this deadly water-borne disease has fallen far below the initial rates registered during its explosive outset. However, cholera continues to cause extensive suffering and needless deaths across the country, particularly among the poor. The urgent need to eliminate transmission of cholera persists: compared to the same period in 2014, the first 4 months of 2015 saw three times the number of cholera cases. Drawing upon epidemiology, clinical work (and clinical knowledge), policy, ecology, and political economy, and informed by ethnographic data collected in a rural area of Haiti called Bocozel, this paper evaluates the progress of the nation’s 10-year Plan for the Elimination of Cholera. Bocozel is a rice-producing region where most people live in extreme poverty. The irrigation network is decrepit, the land is prone to environmental shocks, fertilizer is not affordable, and the government’s capacity to assist farmers is undermined by resource constraints. When peasants do have rice to sell, the price of domestically grown rice is twice that of US-imported rice. Canal water is not only used to irrigate thousands of acres of rice paddies and sustain livestock, but also to bathe, wash, and play, while water from wells, hand pumps, and the river is used for drinking, cooking, and bathing. Only one out of the three government-sponsored water treatment stations in the research area is still functional and utilized by those who can afford it. Latrines are scarce and often shared by up to 30 people; open defecation remains common. Structural vulnerabilities cut across all sectors – not just water, sanitation, health care, and education, but agriculture, environment, (global and local) commerce, transportation, and governance as well. These are among the hidden sicknesses that impede Haiti and its partners’ capacity to eliminate cholera. PMID:27307774

  6. Leisure and social participation in patients 4–10 years after aneurysmal subarachnoid haemorrhage

    Buunk, Anne M.; Groen, Rob J. M.; Veenstra, Wencke S.; Spikman, Jacoba M.

    2015-01-01

    Objective: To investigate the long-term resumption of leisure and social activities in patients with aneurysmal subarachnoid haemorrhage (aSAH) and to determine the role of executive dysfunction and aneurysms in anterior brain regions in particular. Method: Leisure and social functioning of 200 pati

  7. Diagnostic accuracy of frozen section in Central nervous system lesions, a 10-year study.

    Maliheh KHODDAMI*

    2015-01-01

    Full Text Available How to Cite This Article: Khoddami M, Akbarzadeh A, Mordai A, Bidari Zerehpoush F, Alipour H, Samadzadeh S, Alipour B.Diagnostic Accuracy of Frozen Section of Central Nervous System Lesions: A 10-Year Study. Iran J Child Neurol. 2015 Winter;9(1:25-30. AbstractObjectiveDefinitive diagnosis of the central nervous system (CNS lesions is unknown prior to histopathological examination. To determine the method and the endpoint for surgery, intraoperative evaluation of the lesion helps the surgeon.In this study, the diagnostic accuracy and pitfalls of using frozen section (FS ofCNS lesions is determined.Materials & MethodsIn this retrospective study, we analyzed the results of FS and permanent diagnoses of all CNS lesions by reviewing reports from 3 general hospitals between March 2001 and March 2011.Results273 cases were reviewed and patients with an age range from 3 to 77 years of age were considered. 166 (60.4% had complete concordance between FS and permanent section diagnosis, 83 (30.2% had partial concordance, and 24 cases (9.5% were discordant. Considering the concordant and partially concordant cases, the accuracy rate was 99.5%, sensitivity was 91.4%, specificity was 99.7%, and positive and negative predictive values were 88.4% and 99.8%, respectively.ConclusionOur results show high sensitivity and specificity of FS diagnosis in the evaluation of CNS lesions. A Kappa agreement score of 0.88 shows high concordance for FS results with permanent section. Pathologist’s misinterpretation, small biopsy samples (not representative of the entire tumor, suboptimal slides, and inadequate information about tumor location and radiologic findings appear to be the major causes for these discrepancies indicated from our study. ReferencesTaxy JB, Anthony G. Biopsy interpretation: the frozen section. 1st ed. China: Lippincott Williams & Wilkins; 2010. P.301-3.Somerset HL, Kleinschmidt-DeMasters BK. Approach to the intraoperative consultation for

  8. Clinicopathological Characteristics of Mucinous Breast Cancer: A Retrospective Analysis of a 10-Year Study

    Chen, Bo; Chen, Zhanhong; Wang, Xiaojia

    2016-01-01

    Background Mucinous breast carcinoma (MC) is a special type of breast cancer that presents with a large amount of extracellular mucin. MC comprises approximately 4% of all invasive breast cancers. This type of tumor has a better prognosis and higher incidence in peri- and post-menopausal patients. Pathologically, there are two main subtypes of MC: pure and mixed. In this study, we describe 10 years of experience with MC at the Zhejiang Cancer Hospital in China, specifically, clinical data, histological findings and immunohistochemical features. Methods We identified MC patients who were diagnosed as operable and completed clinical treatment from January 2001 to January 2011. The clinicopathological data included the age at diagnosis, tumor size, TNM stage, presence and number of lymph node (LN) metastases, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) status and p53 expression. If the tumor was defined as mixed mucinous carcinoma (MMC), IHC was performed on a non-mucinous part, such as invasive ductal and lobular cancer. We evaluated the clinical characteristics of all MC patients using chi-square, one-way ANOVA and LSD tests. We also studied the correlations between all of the clinical parameters and LN metastasis in a binary logistic regression analysis. We used ten consecutive years of data that were collected at Zhejiang Cancer Hospital. Results We identified 48 cases of pure mucinous carcinoma (PMC) and 77 cases of MMC. The 48 PMC cases consisted of 38 PMC-A and 10 PMC-B subtypes. The MMCs were divided into two groups, those with partial mixed mucinous breast carcinoma (pMMC, 58 cases) and those with main mixed mucinous breast carcinoma (mMMC, 19 cases). pMMC was defined by tumors with less than 50% mucinous components, while mMMC was defined by tumors where the mucinous component accounted for 50% to 90% of the tumor. No significant differences in the clinicopathological characteristics were noted

  9. ESA SMART-1 mission: review of results and legacy 10 years after launch

    Foing, Bernard

    2014-05-01

    We review ESA's SMART-1 highlights and legacy 10 years after launch. The SMART-1 mission to the Moon achieved record firsts such as: 1) first Small Mission for Advanced Research and Technology; with spacecraft built and integrated in 2.5 years and launched 3.5 years after mission approval; 2) first mission leaving the Earth orbit using solar power alone with demonstration for future deep space missions such as BepiColombo; 3) most fuel effective mission (60 litres of Xenon) and longest travel (13 month) to the Moon!; 4) first ESA mission reaching the Moon and first European views of lunar poles; 5) first European demonstration of a wide range of new technologies: Li-Ion modular battery, deep-space communications in X- and Ka-bands, and autonomous positioning for navigation; 6) first lunar demonstration of an infrared spectrometer and of a Swept Charge Detector Lunar X-ray fluorescence spectrometer ; 7) first ESA mission with opportunity for lunar science, elemental geochemistry, surface mineralogy mapping, surface geology and precursor studies for exploration; 8) first controlled impact landing on the Moon with real time observations campaign; 9) first mission supporting goals of the ILEWG/COSPAR International Lunar Exploration Working Group in technical and scientific exchange, international collaboration, public and youth engagement; 10) first mission preparing the ground for ESA collaboration in Chandrayaan-1, Chang'E1-2-3 and near-future landers, sample return and human lunar missions. The SMART-1 technology legacy is applicable to geostationary satellites and deep space missions using solar electric propulsion. The SMART-1 archive observations have been used to support scientific research and prepare subsequent lunar missions and exploration. Most recent SMART-1 results are relevant to topics on: 1) the study of properties of the lunar dust, 2) impact craters and ejecta, 3) the study of illumination, 4) observations and science from the Moon, 5) support to

  10. Clinicopathological Characteristics of Mucinous Breast Cancer: A Retrospective Analysis of a 10-Year Study.

    Lei Lei

    Full Text Available Mucinous breast carcinoma (MC is a special type of breast cancer that presents with a large amount of extracellular mucin. MC comprises approximately 4% of all invasive breast cancers. This type of tumor has a better prognosis and higher incidence in peri- and post-menopausal patients. Pathologically, there are two main subtypes of MC: pure and mixed. In this study, we describe 10 years of experience with MC at the Zhejiang Cancer Hospital in China, specifically, clinical data, histological findings and immunohistochemical features.We identified MC patients who were diagnosed as operable and completed clinical treatment from January 2001 to January 2011. The clinicopathological data included the age at diagnosis, tumor size, TNM stage, presence and number of lymph node (LN metastases, estrogen receptor (ER, progesterone receptor (PR and human epidermal growth factor receptor-2 (HER2 status and p53 expression. If the tumor was defined as mixed mucinous carcinoma (MMC, IHC was performed on a non-mucinous part, such as invasive ductal and lobular cancer. We evaluated the clinical characteristics of all MC patients using chi-square, one-way ANOVA and LSD tests. We also studied the correlations between all of the clinical parameters and LN metastasis in a binary logistic regression analysis. We used ten consecutive years of data that were collected at Zhejiang Cancer Hospital.We identified 48 cases of pure mucinous carcinoma (PMC and 77 cases of MMC. The 48 PMC cases consisted of 38 PMC-A and 10 PMC-B subtypes. The MMCs were divided into two groups, those with partial mixed mucinous breast carcinoma (pMMC, 58 cases and those with main mixed mucinous breast carcinoma (mMMC, 19 cases. pMMC was defined by tumors with less than 50% mucinous components, while mMMC was defined by tumors where the mucinous component accounted for 50% to 90% of the tumor. No significant differences in the clinicopathological characteristics were noted between the patients

  11. Cyberbullying among Finnish adolescents – a population-based study

    Lindfors Pirjo L

    2012-11-01

    Full Text Available Abstract Background Cyberbullying, threatening or harassing another via the internet or mobile phones, does not cause physically harm and thus the consequences are less visible. Little research has been performed on the occurrence of cyberbullying among adolescents or the perception of its seriousness. Only a few population-based studies have been published, none of which included research on the witnessing of cyberbullying. Here, we examined exposure to cyberbullying during the last year, and its frequency and perceived seriousness among 12 to 18-year-old adolescents in Finland. We studied four dimensions of cyberbullying: being a victim, bully, or both victim and bully of cyberbullying, and witnessing the cyberbullying of friends. Methods Self-administered questionnaires, including four questions on cyberbullying, were mailed to a representative sample of 12-, 14-, 16-, and 18-year-old Finns in 2009 (the Adolescent Health and Lifestyle Survey. The respondents could answer via the internet or paper questionnaire. Results The number of respondents was 5516 and the response rate was 56%. Girls more often than boys reported experiencing at least one dimension of cyberbullying during the last year. The proportion was highest among 14-year-olds and lowest among 18-year-olds of both sexes. Among girls, the most commonly encountered dimension was witnessing the cyberbullying of friends (16%; and being a victim was slightly more common than being a bully (11% vs. 9%. Among boys, an equal proportion, approximately 10%, had been a victim, a bully, or had witnessed cyberbullying. The proportion of bully-victims was 4%. Serious and disruptive cyberbullying was experienced by 2% of respondents and weekly cyberbullying by 1%; only 0.5% of respondents had been bullied weekly and considered bullying serious and disruptive. Conclusions Adolescents are commonly exposed to cyberbullying, but it is rarely frequent or considered serious or disruptive. Cyberbullying

  12. Sandy desertification trend in western Northeast China Plain in the past 10 years

    2001-01-01

    The west sandy land of the Northeast China Plain is located in the eastern huge sandy belt of mid-latitude in Eurasia and the eastern fringe of desertified land with best bio-climatic conditions in China. With rapid economic development, the deterioration of eco-environment has occurred and the desertification becomes very obvious. The first part of this paper studies the regional differences of landscape patterns and explores the regional differences of desertification. The second part aims to reveal the dynamics of desertification in the 1990s by using NOAA/AVHRR data and thematic data in GIS database. This work lays a scientific basis for the rehabilitation and development of the sandy lands.

  13. Genetic diversity of bovine viral diarrhoea viruses (BVDV) in Denmark during a 10-year eradication period

    Uttenthal, Åse; Stadejek, T.; Nylin, B.

    2005-01-01

    A 243 base-pair fragment of the 5'- untranslated region (5'-UTR) of bovine viral diarrhoea virus (BVDV) was RT-PCR amplified from tissue samples (after one passage) or from plasma collected from Danish cattle in 1962 (1), 1993 (7), or in 2002-03 (28) when BVD was almost extinct as a result of a 6...... subtype, the samples collected in 2002-2003 belonged to Id (22 samples), 1b (5 samples) and le (I sample) subtypes. In five herds, materials from two animals were obtained for PCR analysis. In four of five herds the sequences of the two viruses were identical, but in one herd the obtained sequences...

  14. Performance and Clique Analysis of the Iranian Universities and Research Institutions Informetrics: 10 Years Study

    Mohammadamin Erfanmanesh

    2016-03-01

    Full Text Available Objective: The current research aims to investigate the co-authorship network of Iranian universities and research institutions in informetrics research during 2002-2012 using social network analysis. Methodology: Using scientometric approach and social network analysis measures, this paper studies co-authorship network of Iranian universities and research institutions in informetrics research. The research population includes 779 articles published in both English and Persian and indexed in 4th edition of scientometrics bibliography during 2002-2012. First, the co-authorship matrix of institutions was drawn by using excel software second, the UCINET and VOSviewer software were utilized for data analysis. Findings: Results revealed that institutions like Tehran University, Tehran University of Medical Sciences, Islamic Azad University, Tarbiat Modares University, Shahed University, Shahid Chamran University of Aheaz, Regional Information Center for Science and Technology, and National Research Institute for Science Policy play the most important and central roles in the informetrics collaboration network based on productivity, centrality, and collaboration measures. The highest number of co-authored papers in this network have been written by the following pairs of institutions: “Tarbiat Modares University- Shahed University”, “Payame Noor University- Regional Information Center for Science and Technology”, and “Shahed University- National Research Institute for Science Policy” respectively. Conclusion: Results of the clique analysis showed that this network is made of 12 cliques with at least 5 institutions. Tehran University and Islamic Azad University were in the highest number of subgroups of the network with 7 cliques.

  15. How much does PSA matter after 10 years? Outcomes in 10-year clinical NED survivors after definitive radiotherapy for T1-3N0M0 prostate cancer

    Objective: Institutional policy in the 1970's and 80's dictated that patients with potentially curable prostate cancer undergo PLND prior to definitive XRT. Our group has reported 80% 15-year actuarial cause-specific survival for the 147 patients so treated. Analysis was made of PSA values and clinical outcomes of patients who were clinically without evidence of disease (NED) 10 years after a negative staging pelvic lymphadenectomy and definitive radiation therapy (XRT) for prostate cancer. Materials and Methods: One hundred patients underwent staging pelvic lymphadenectomy between 11/1/74 and 1/1/86, of which 98 had pathologically negative lymph nodes (N0). These patients subsequently underwent definitive radiotherapy; a median dose of 66.6 Gy (range 63-70.2 Gy) was delivered. Forty-two N0 patients with sufficient follow-up were alive and clinically NED 10 years post-operatively. None of these patients had ever received hormonal therapy. Distribution by disease stage at diagnosis was: Stage A2: 12 pts; Stage B: 19 pts; Stage B2/ C: 6 pts; Stage C: 5 pts. Median follow-up was 12 years 4 months, with a minimum follow-up of 10 years. Results: Of the 42 NED survivors at 10 years, 5 pts died subsequently without PSA data, remaining clinically NED (median 13y 3m post-operatively); 37 patients were alive and without evidence of disease off all therapy at 10 years post-operatively. Most recent PSA data reveal: Bone scans were performed on the 8 patients with elevated PSA. These revealed a single patient with diffuse but asymptomatic bone metastases. Ultrasound-guided sextant biopsies were performed on one 78-year-old patient with elevated PSA 19 years post-operatively, revealing an asymptomatic local recurrence. Conclusions: Radiation therapy delivered to a surgically staged population of prostate cancer patients contributes to normalization of PSA in 78% ((29(37))) of patients with ≥10 year follow-up. Most of these patients will have PSA levels ≤ 1.5 ng/ml. More

  16. Rosetta begins its 10-year journey to the origins of the Solar System

    2004-03-01

    Rosetta’s mission began at 08h17 CET (07h17 GMT) on 2 March when a European Ariane 5 launch vehicle liftered off from the Guiana Space Centre, Europe’s spaceport in Kourou, French Guiana. The launcher successfully placed its upper stage and payload into an eccentric coast orbit (200 x 4000 km). About two hours later, at 10h14 CET (09h14 GMT) the upper stage ignited its own engine to reach an escape velocity in order to leave the Earth’s gravity field and enter heliocentric orbit. The Rosetta probe was released about 18 minutes later. “After the recent success of Mars Express, Europe is now heading to deep space with another fantastic mission. We will have to be patient, as the rendezvous with the comet will not take place until ten years from now, but I think it’s worth the wait” said ESA’s Director General Jean-Jacques Dordain witnessing the launch from Kourou. ESA’s Operations Centre (ESOC) in Darmstadt, Germany, has established contact with the probe as it flies away from Earth at a relative speed of about 3.4 km/s. ESOC will be in charge of Rosetta operations and orbit determination throughout the mission. During the next eight months, the spacecraft’s onboard systems will be checked and its science payload will be commissioned. A 10-year odyssey Rosetta will be reactivated for planetary flybys, which will be used to modify its trajectory through gravity assist manoeuvres. During the trip, the probe could also observe one or more asteroids, observation of asteroids being one of the mission's secondary objectives. The first planetary encounter will be in March 2005, as Rosetta flies by the Earth for the first time. The gravity assist will boost Rosetta into an orbit that will take it to Mars two years later. During its close encounter with Mars in February 2007, Rosetta will approach to a distance of about 200 km and conduct science observations. This Martian flyby will be followed by another Earth flyby in November the same year. Both

  17. National population based HIV prevalence surveys in sub‐Saharan Africa: results and implications for HIV and AIDS estimates

    García‐Calleja, J M; Gouws, E; Ghys, P D

    2006-01-01

    Background Sentinel surveillance among pregnant women attending antenatal clinics (ANCs) has been the main source of information on HIV trends in sub‐Saharan Africa. These data have also been used to generate national HIV and AIDS estimates. New technologies and resources have allowed many countries to conduct national population based surveys that include HIV prevalence measurement, as an additional source of information on the AIDS epidemic. Methods The authors reviewed the reports of 20 national population based surveys from 19 countries carried out in sub‐Saharan Africa since 2001. They examined the sampling methodology, HIV testing and response rates, and female:male and urban:rural prevalence ratios. They also constructed adjusted prevalence scenarios assuming different relative risks for survey non‐responders. Results The national population based surveys vary considerably in quality, as reflected in the household response rate (ranging from 75.4% to 99.7%), women's testing rate (ranging from 68.2% to 97.3%), and men's testing rate (ranging from 62.2% to 95.4%), while for some surveys detailed response information is lacking. While 95% confidence intervals around the female:male and urban:rural prevalence ratios in individual countries are large, the median female:male ratio of the combined set of surveys results is 1.5 and the median urban:rural ratio 1.7. A scenario assuming that non‐responders have twice the HIV prevalence of those who fully participated in the survey suggests that individual non‐response could result in an adjusted HIV prevalence 1.03 to 1.34 times higher than the observed prevalence. Conclusions Population based surveys can provide useful information on HIV prevalence levels and distribution. This information is being used to improve national HIV and AIDS estimates. Further refinements in data collection, analysis, and reporting, combined with high participation rates, can further improve HIV and AIDS estimates at national and

  18. 10-year record of atmospheric composition in the high Himalayas: source, transport and impact

    Bonasoni, Paolo; Laj, Paolo; Marinoni, Angela; Cristofanelli, Paolo; Maione, Michela; Putero, Davide; Calzolari, Francescopiero; Decesari, Stefano; Facchini, Maria Cristina; Fuzzi, Sandro; Gobbi, Gianpaolo; Sellegri, Karine; Verza, Gianpietro; Vuillermoz, Elisa; Arduini, Jgor

    2016-04-01

    South Asia represents a global "hot-spot" for air-quality and climate impacts. Since the end of the 20th Century, field experiments and satellite observations identified a thick layer of atmospheric pollutants extending from the Indian Ocean up to the atmosphere of the Himalayas. Since large amount of short-lived climate pollutants (SLCPs) - like atmospheric aerosol (in particular, the light-absorbing aerosol) and ozone - characterize this region, severe implications were recognized for population health, ecosystem integrity as well as regional climate impacts, especially for what concerns hydrological cycle, monsoon regimes and cryosphere. Since 2006, the Nepal Climate Observatory - Pyramid (NCO-P, 27.95N, 86.82 E, 5079 m a.s.l.), a global station of the WMO/GAW programme has been active in the eastern Nepal Himalaya, not far from the Mt. Everest. NCO-P is located away from large direct anthropogenic pollution sources. The closest major urban area is Kathmandu (200 km south-west from the measurement site). As being located along the Khumbu valley, the observations are representative of synoptic-scale and mountain thermal circulation, providing direct information about the vertical transport of pollutants/climate-altering compounds to the Himalayas and to the free troposphere. In the framework of international programmes (GAW/WMO, UNEP-ABC, AERONET) the following continuous measurement programmes have been carried out at NCO-P: surface ozone, aerosol size distribution (from 10 nm to 25 micron), total particle number, aerosol scattering and absorption coefficients, equivalent BC, PM1-PM10, AOD by sun-photometry, global solar radiation (SW and LW), meteorology. Long-term sampling programmes for the off-line determination of halogenated gases and aerosol chemistry have been also activated. The atmospheric observation records at NCO-P, now representing the longest time series available for the high Himalayas, provided the first direct evidences about the systematic

  19. 78 FR 46521 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second 10-Year...

    2013-08-01

    ... for the Colorado Springs area for the carbon monoxide (CO) National Ambient Air Quality Standard... Subjects in 40 CFR Part 52 Environmental protection, Air pollution control, Carbon monoxide, Incorporation...; Second 10-Year Carbon Monoxide Maintenance Plan for Colorado Springs AGENCY: Environmental...

  20. 78 FR 56164 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second 10-Year...

    2013-09-12

    ... for the Fort Collins area for the carbon monoxide (CO) National Ambient Air Quality Standard (NAAQS... CFR Part 52 Environmental protection, Air pollution control, Carbon monoxide, Incorporation by...; Second 10-Year Carbon Monoxide Maintenance Plan for Fort Collins AGENCY: Environmental Protection...

  1. Treatment and violent behavior in persons with first episode psychosis during a 10-year prospective follow-up study

    Langeveld, Johannes; Bjørkly, Stål; Auestad, Bjørn;

    2014-01-01

    found to be predictive of violent behavior during the year preceding the 10-year follow-up. CONCLUSION: After treatment initiation, the overall prevalence of violence in psychotic patients drops gradually to rates close to those of the general population. However, persistent illicit drug abuse is a...

  2. Race, socioeconomic status, and obesity in 9- to 10 year-old girls : The NHLBI Growth and Health Study

    Kimm, SYS; Obarzanek, E; Barton, BA; Aston, CE; Similo, SL; Morrison, JA; Sabry, ZI; Schreiber, GB; McMahon, RP

    1996-01-01

    The purpose of this investigation was to determine whether measures of socioeconomic status (SES) are inversely associated with obesity in 9- to 10-year-old black and white girls and their parents. Subjects were participants in the Growth and Health Study (NGHS) of the National Heart, Lung, and Bloo

  3. Severe episodic viral wheeze in preschool children : High risk of asthma at age 5-10 years

    Kappelle, Lucie; Brand, Paul L. P.

    2012-01-01

    In population studies, most children with episodic viral wheeze (EVW) become symptom free by 6 years. We studied the outcome of children with severe EVW, treated and followed up in hospital. We followed up 78 children <4 years, managed by paediatricians for severe EVW, to the age of 5-10 years. We r

  4. Shift work and mental health sickness absence : a 10-year observational cohort study among male production workers

    Norder-Kuper, Giny; Roelen, Corne A. M.; Bultmann, Ute; van der Klink, Jac J. L.

    2015-01-01

    Objectives Epidemiological studies investigating mental-health-related sickness absence (SA) among shift workers are lacking. This 10-year observational study investigated the risk of mental health SA among shift compared with day workers. Methods The data of 5826 male production workers were used f

  5. Development of a mathematical phantom representing a 10-year-old child for use in internal dosimetry calculations

    With the increased growth of nuclear energy generating facilities, estimates of absorbed radiation dose to human population groups (e.g., children) are required. In addition, children are being exposed to many nuclear medicine procedures and accurate dose estimates are needed. The main purpose of this research is to design a mathematical phantom representing as closely as possible a 10-year old child

  6. Comparing 9 to 10 Years Old Children's Performance in Tennis and Physical Fitness Activities

    Olcucu, Burcin

    2013-01-01

    The aim of the study is to determine the degree of performance-related physical coordination of elementary education children (male and female) that play tennis according to their age and gender and to investigate the relationship between their motor ability tests and performances. A total of 210 children tennis players (9 to 10 years; 105 males…

  7. Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report

    De la Pena, Jennifer; Wapnir, Irene

    2008-01-01

    A 50 year old woman with a 10-year history of systemic lupus erythematosus (SLE) and intermittent low-dose cyclophosphamide therapy developed a palpable mass at the periphery of her left breast. Ultrasound guided core biopsy revealed a spindle cell neoplasm characterized on final pathology as a low grade leiomyosarcoma.

  8. Squamous cell carcinoma and suspect peripheral nerve sheath tumor in a 10-year-old Paint horse

    Reid, Natalie

    2009-01-01

    A round mass 4 cm in diameter was present on the proximal rostro-lateral border of the right pinna of a 10-year-old, gelded, Paint horse. A preliminary histopathological diagnosis of a potential squamous cell carcinoma and peripheral nerve sheath tumor was made, and the lesion was resected at the base of the lateral edge of the ear.

  9. The Dynamics of Free Recall and Their Relation to Rehearsal between 8 and 10 Years of Age

    Lehmann, Martin; Hasselhorn, Marcus

    2010-01-01

    The present study longitudinally examined changes in recall in children between the ages of 8 and 10 years. Given the increasingly sophisticated use of memory strategies during this developmental period, correspondences between study and recall dynamics were of particular interest. Seventy-six children performed free-recall tasks on 5 occasions…

  10. Population-based treatment and outcomes of Stage I uterine serous carcinoma

    Putten, L.J.M. van der; Hoskins, P.; Tinker, A.; Lim, P.; Aquino-Parsons, C.; Kwon, J.S.

    2014-01-01

    OBJECTIVE: Uterine serous carcinoma (USC) is a rare type of endometrial cancer that often recurs in patients with Stage I disease. Our objective was to evaluate treatment and outcomes in Stage I USC in the context of a population-based study. METHODS: This was a population-based retrospective cohort

  11. Universal Screening for Emotional and Behavioral Problems: Fitting a Population-Based Model

    Schanding, G. Thomas, Jr.; Nowell, Kerri P.

    2013-01-01

    Schools have begun to adopt a population-based method to conceptualizing assessment and intervention of students; however, little empirical evidence has been gathered to support this shift in service delivery. The present study examined the fit of a population-based model in identifying students' behavioral and emotional functioning using a…

  12. Event detection using population-based health care databases in randomized clinical trials

    Thuesen, Leif; Jensen, Lisette Okkels; Tilsted, Hans Henrik; Mæng, Michael; Terkelsen, Christian; Thayssen, Per; Ravkilde, Jan; Christiansen, Evald Høj; Bøtker, Hans Erik; Madsen, Morten; Lassen, Jens F

    2013-01-01

    To describe a new research tool, designed to reflect routine clinical practice and relying on population-based health care databases to detect clinical events in randomized clinical trials.......To describe a new research tool, designed to reflect routine clinical practice and relying on population-based health care databases to detect clinical events in randomized clinical trials....

  13. Study of spatial distribution of sandy desertification in North China in recent 10 years

    WANG Tao; WU Wei; XUE Xian; SUN Qingwei; CHEN Guangting

    2004-01-01

    Sandy desertification is a land degradation characterized by wind erosion, mainly resulted from the excessive human activities in arid, semiarid and part of sub-humid regions in North China. It is one of main kinds of desertification/land degradation as well as water-soil erosion and salinization in China. Rapid and continuous spread of sandy desertification during last 50 years has created a major environmental and socio-economic problem in North China. Remote sensing monitored results in 2000 showed that the sandy desertified land area has been 38.57×104 km2. The area of potential to slightly sandy desertified land is 13.93×104 km2, moderately land 9.977×104 km2, severely land 7.909×104 km2 and very severely land 6.756×104km2. Sandy desertification mainly occurs in the semi-arid mixed farming-grazing zone and its northern rangeland zone, semi-arid dryland rainfed cropping zone and arid oasis-desert margin zone. The average annually developmental rate of sandy desertified land increased from 2,100tion in North China is "overall deterioration, while local rehabilitation". Already achieved rehabilitation results and monitoring assessment show that about 60% of desertified land in North China can be restored under the conditions of rational land-use ways and intensity.

  14. Middle and Lower Face Soft Tissue Reconstruction: A 10-Year Retrospective Study.

    Wusiman, Patiguli; Tuerxun, Julaiti; Ling, Wang; Tuerdi, Maimaitituerxun; Maimaiti, Abudukelimujiang; Tao, Yao Zhi; Saimait, Adilijiang; Mijiti, Ainiwaer; Moming, Adili

    2016-09-01

    Retrospectively analyze the reconstruction methods and surgical outcomes of patients with middle and lower face soft tissue defects treated at our hospital over the past 10 years. 200 patients with middle and lower face soft tissue defects were surgically reconstructed at our hospital. Medical charts were retrospectively reviewed and analyzed to abstract the pertinent information. The lesion was mainly at the eyelid, lips, chin and nasal-cheek region. There were 41 (63.08 %) men and 24 (36.92 %) women. In our study, male to female ratio = 1.7:1. We used direct closure for night patients, local flap for 141 patients, free flap for 38 patients, combined flap for 12 patients involving extensive mid face and lower face defects. Most patients had their tumor resected and reconstructed in single stage procedure mostly with local advancement flap, and no flap failure was presented post-operatively. Middle and lower face soft tissue defects can be successfully treated with local flap in a single stage approach and step-by-step approach. PMID:27508131

  15. Participation Trends of Underrepresented Students from 10-years of an Ocean Science REU Program

    Donohue, K. A.; Pockalny, R. A.

    2011-12-01

    The Summer Undergraduate Research Fellowships in Oceanography (SURFO) program at the Graduate School of Oceanography/University of Rhode Island is a NSF-funded Research Experience for Undergraduates (REU) site program with a programmatic research niche focused on quantitative aspects of Oceanography. Each summer-cohort includes 9-12 participants (rising seniors and juniors) who are paired with a primary research advisor and a graduate-student mentor. The primary components of the 10-week program include a 3-week introductory phase and a 7-week core-research phase. A review of SURFO application material from 2000 to present reveals demographic and temporal trends that may be helpful for targeted recruitment of underrepresented students. The demographic trends include a regional geographical bias with a significant proportion of applicants (45%) and participants (40%) attending college in neighboring states. Overall, the percentage of applicants and participants in the SURFO program is slightly greater than nationwide graduation rates for female students, minority students, and first-generation students. The temporal trends identify several factors that may be related to program increases in minority student applications and participation, including: the site director's participation in an NSF panel review of REU proposals, a partnership with a university with a significant minority population, ease of access to application materials, and active participation in minority-serving talent development programs (e.g., MSPHD). Correlations are not observed for new, updated websites or modest changes in site program personnel.

  16. Histological review of skin cancers in African Albinos: a 10-year retrospective review

    Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers. This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011. A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC. Squamous cell carcinoma is more common than basal cell carcinoma in African albinos

  17. The subtropical cloud regime transition: A 10-year view from AIRS, MODIS and ERA-Interim

    Schreier, M. M.; Kahn, B. H.; Yue, Q.; Suselj, K.

    2012-12-01

    We describe a synergistic approach using multiple satellite observations to describe the statistical behavior of cloud and thermodynamic fields within the subtropical cloud regime transition. Cloud parameters obtained from the MODerate resolution Imaging Spectroradiometer (MODIS) are combined with atmospheric thermodynamic profile retrievals from the Atmospheric Infrared Sounder (AIRS) to quantify changes in the statistical moments over a decade of observations. The analysis is done across the transition of stratocumulus to trade cumulus in several areas around the globe. We analyze differences in the statistical behavior of cloud parameters, lower tropospheric stability, variations in temperature (T) and water vapor (q) profiles, and high-spectral-resolution infrared radiances, and demonstrate differences and similarities among the different cloud types. The statistics are compared to European Center for Medium Range Weather Forecasting Interim Re-analysis (ERA-Interim) data in the same region and time period for the same cloud types. This type of a statistical comparison of provides additional important constraints that are useful for the assessment of satellite retrievals and evaluating atmospheric variability in climate models.

  18. A 10 year retrospective study of surgical outcomes of adult intracranial pilocytic astrocytoma.

    Ye, Joshua Mingsheng; Ye, Mingwei Joel; Kranz, Sevastjan; Lo, Patrick

    2014-12-01

    Pilocytic astrocytomas (PA) are benign neoplasms commonly located in the cerebellum with a peak incidence in the first two decades of life. PA occurrence in adults is rare and very little information is available in the literature about tumour characteristics in this population. This study retrospectively identified 20 adults with PA. The characteristics of the tumour, treatment modalities and patient outcomes are discussed, as well as identifying factors that may be associated with worse prognosis. The mean age at diagnosis was 27 years. The majority of PA were located in the posterior fossa. Other tumour locations included the cerebral hemispheres, brainstem, tectal plate and optochiasmatic region (optic chiasm, hypothalamus and third ventricle). All patients in this study underwent surgery, two received adjuvant chemotherapy and one received adjuvant radiotherapy. Tumour recurrence occurred in six patients and two eventually died from the disease. When achieved, complete tumour resection was found to be curative. Tumour location affects extent of surgical resection; tumours in inaccessible locations were associated with higher rates of recurrence. Overall survival and progression free survival rates were 87% and 60% respectively. The degree of surgical resection and tumour location were found to affect prognosis. Unfavourable outcomes were observed in these adults with PA compared to those expected for a younger population, suggesting a possible association between age and outcome. PMID:25065843

  19. Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer.

    Yagishita, Shigehiro; Horinouchi, Hidehito; Yorozu, Takashi; Kitazono, Satoru; Mizugaki, Hidenori; Kanda, Shintaro; Fujiwara, Yutaka; Nokihara, Hiroshi; Yamamoto, Noboru; Mori, Taisuke; Tsuta, Koji; Sumi, Minako; Tamura, Tomohide

    2014-02-01

    A 53-year-old female patient was admitted with pain and a progressively enlarging mass in the right upper chest. Chest computed tomography revealed a mass lesion in the region of the right upper ribs. Ten years prior to this admission, the patient had undergone right lobectomy for lung adenocarcinoma. One year after the surgery, follow-up computed tomography had revealed tumor recurrence in the mediastinal and supraclavicular lymph nodes, and the patient had been treated by chemoradiotherapy. Thereafter, regular follow-up had revealed no evidence of recurrence of the non-small-cell lung cancer. Histopathological findings revealed proliferation of spindle-shaped malignant tumor cells in a background of osteoid, consistent with the diagnosis of osteosarcoma. The location of the tumor was consistent with the radiation field. Based on the clinicopathological findings, the patient was diagnosed as having secondary osteosarcoma occurring as a result of the chemoradiotherapy administered previously for the recurrent non-small-cell lung cancer. Unfortunately, the patient died of rapid progression of the osteosarcoma within a week of admission to the hospital. The autopsy revealed contiguous invasion by the tumor of the heart, with massive thrombus formation. The peripheral pulmonary arteries were diffusely occluded by metastatic tumors. Our case serves to highlight the risk of development of secondary sarcoma as a life-threatening late complication after chemoradiotherapy for locally advanced non-small-cell lung cancer, even after complete cure of the primary tumor. PMID:24338556

  20. High nasopharyngeal carriage of non-vaccine serotypes in Western Australian aboriginal people following 10 years of pneumococcal conjugate vaccination.

    Deirdre A Collins

    Full Text Available BACKGROUND: Invasive pneumococcal disease (IPD continues to occur at high rates among Australian Aboriginal people. The seven-valent pneumococcal conjugate vaccine (7vPCV was given in a 2-4-6-month schedule from 2001, with a 23-valent pneumococcal polysaccharide vaccine (23vPPV booster at 18 months, and replaced with 13vPCV in July 2011. Since carriage surveillance can supplement IPD surveillance, we have monitored pneumococcal carriage in western Australia (WA since 2008 to assess the impact of the 10-year 7vPCV program. METHODS: We collected 1,500 nasopharyngeal specimens from Aboriginal people living in varied regions of WA from August 2008 until June 2011. Specimens were cultured on selective media. Pneumococcal isolates were serotyped by the quellung reaction. RESULTS: Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were carried by 71.9%, 63.2% and 63.3% respectively of children <5 years of age, and 34.6%, 22.4% and 27.2% of people ≥5 years. Of 43 pneumococcal serotypes identified, the most common were 19A, 16F and 6C in children <5 years, and 15B, 34 and 22F in older people. 7vPCV serotypes accounted for 14.5% of all serotypeable isolates, 13vPCV for 32.4% and 23vPPV for 49.9%, with little variation across all age groups. Serotypes 1 and 12F were rarely identified, despite causing recent IPD outbreaks in WA. Complete penicillin resistance (MIC ≥2µg/ml was found in 1.6% of serotype 19A (5.2%, 19F (4.9% and 16F (3.2% isolates and reduced penicillin susceptibility (MIC ≥0.125µg/ml in 24.9% of isolates, particularly 19F (92.7%, 19A (41.3%, 16F (29.0%. Multi-resistance to cotrimoxazole, tetracycline and erythromycin was found in 83.0% of 23F isolates. Among non-serotypeable isolates 76.0% had reduced susceptibility and 4.0% showed complete resistance to penicillin. CONCLUSIONS: Ten years after introduction of 7vPCV for Aboriginal Australian children, 7vPCV serotypes account for a small proportion of carried

  1. 10-year epidemiological profile changes for cervical and endometrial cancer patients treated by radiotherapy in the Pernambuco state, Brazil

    . The most affected age group was 51-70 years old for both profiles. Taking into account the results, after 10 years, the profile of cervical and endometrial cancer has changed expressively in the female population of Pernambuco state. It was observed that, in 2008-2009, patients have arrived at the radiotherapy service with uterus cancer in the advanced stages, although the Brazilian Ministry of Health have expanded its health policy for cervical cancer prevention by the Pap smear screening. Therefore, new strategies become necessary to prevent and control the cervical and endometrial cancer in the Pernambuco State. (author)

  2. Estimating SO2 emissions from a large point source using 10 year OMI SO2 observations: Afsin Elbistan Power Plant

    Kaynak Tezel, Burcak; Firatli, Ertug

    2016-04-01

    SO2 pollution has still been a problem for parts of Turkey, especially regions with large scale coal power plants. In this study, 10 year Ozone Monitoring Instrument (OMI) SO2 observations are used for estimating SO2 emissions from large point sources in Turkey. We aim to estimate SO2 emissions from coal power plants where no online monitoring is available and improve the emissions given in current emission inventories with these top-down estimates. High-resolution yearly averaged maps are created on a domain over large point sources by oversampling SO2 columns for each grid for the years 2005-2014. This method reduced the noise and resulted in a better signal from large point sources and it was used for coal power plants in U.S and India, previously. The SO2 signal over selected power plants are observed with this method, and the spatiotemporal changes of SO2 signal are analyzed. With the assumption that OMI SO2 observations are correlating with emissions, long-term OMI SO2 observation averages can be used to estimate emission levels of significant point sources. Two-dimensional Gaussian function is used for explaining the relationships between OMI SO2 observations and emissions. Afsin Elbistan Power Plant, which is the largest capacity coal power plant in Turkey, is investigated in detail as a case study. The satellite scans within 50 km of the power plant are selected and averaged over a 2 x 2 km2 gridded domain by smoothing method for 2005-2014. The yearly averages of OMI SO2 are calculated to investigate the magnitude and the impact area of the SO2 emissions of the power plant. A significant increase in OMI SO2 observations over Afsin Elbistan from 2005 to 2009 was observed (over 2 times) possibly due to the capacity increase from 1715 to 2795 MW in 2006. Comparison between the yearly gross electricity production of the plant and OMI SO2 observations indicated consistency until 2009, but OMI SO2 observations indicated a rapid increase while gross electricity

  3. 10-year epidemiological profile changes for cervical and endometrial cancer patients treated by radiotherapy in the Pernambuco state, Brazil

    Cantinha, Rebeca S.; Santos, Mariana L.O.; Franca, Elvis J., E-mail: ejfranca@yahoo.com.br, E-mail: marianasantos_ufpe@hotmail.com, E-mail: rebecanuclear@gmail.com [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Pessoa, Juanna G.; Melo, Ana M.M.A.; Amancio, Francisco F., E-mail: amdemelo@hotmail.com, E-mail: amanciobike@gmail.com, E-mail: juannapessoa@gmail.com, E-mail: marianasantos_ufpe@hotmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Biofisica e Radiobiologia; Oliveira Neto, Aristides M.; Melo, Jonathan A., E-mail: aristidesoliveira466@hotmail.com, E-mail: jonathan@truenet.com.br [Centro de Radioterapia de Pernambuco (CERAPE), Santo Amaro, PE (Brazil)

    2014-07-01

    . The most affected age group was 51-70 years old for both profiles. Taking into account the results, after 10 years, the profile of cervical and endometrial cancer has changed expressively in the female population of Pernambuco state. It was observed that, in 2008-2009, patients have arrived at the radiotherapy service with uterus cancer in the advanced stages, although the Brazilian Ministry of Health have expanded its health policy for cervical cancer prevention by the Pap smear screening. Therefore, new strategies become necessary to prevent and control the cervical and endometrial cancer in the Pernambuco State. (author)

  4. Population based screening for prostate cancer : tumor characteristics

    Cruijsen, Ingrid W

    2008-01-01

    markdownabstract__Abstract__ The European Randomized study of Screening for Prostate Cancer is a multi-centre randomized controlled trial to examine whether screening for prostate cancer has an effect on prostate cancer mortality. The total study cohort consists of 268.000 men in eight different European Countries. In the Netherlands the study is being conducted in the region of Rotterdam by the study group of the Erasmus Medical Centre Rotterdam. Between 1993 and 2000 a total of 42,376 men (...

  5. Rising Dust Aerosol Pollution at Ilorin in the Sub-sahel Inferred from 10-year Aeronet Data: Possible Links to Persisting Drought Conditions

    Okey K. Nwofor

    2010-10-01

    Full Text Available AERONET Aerosol Optical Depth (AOD and A ngstrom Exponent (α data of Ilorin in the sub- Sahel region of Nigeria (8º32'N; 4º34'E for the first 10 years of measurements (April 1998-April 2008 are analyzed with the aim of deducing recent trends in dust aerosol loading in the area. The data indicates averagely increasing trends in AOD for both the dry and wet seasons. Analysis of the α data for two halves (1998-2002/03 and 2003-2007/08 of the progressive 10-year data span (1998-2008 reveals a slight increase (of ~ 8% in the probability density of the dominant mode of the sm aller α (α<1 fraction (associated w ith dust aerosols in the second part (2003-2007/08 compared to its value in the first part (1998-2002/03. The α peak also shifted to a lower value during the second half of the series suggesting increased coarseness of particles possibly due to presence of more dust aerosols. Considering that Sahara dust and biomass burning aerosols are both usually not significant in the wet season, the observed growing AOD trends in both seasons and then the α variability pattern suggest possible intensification of local dust pollutions at the site within the 10 year period considered. These possibilities are linked to the persistent long-term drought and resulting aridity of the area. Given a scenario where aerosol loading might inhibit rainfall, as some studies suggest, a reciprocal (positive feedback action of the form; dust loading ↔ drought is probably intensifying in the area.

  6. Study on occupational radiation exposure of workers in Europe. ESOREX 2005 - evaluation of 10 years period

    ESOREX project has been presented several times already in international forum (e.g. IRPA11, Madrid, Eurados Conference IM2005, 2nd European IRPA Congress, Paris 2006, IRPA Regional Congress in Brasov, Romania 2007). The Survey consists of two parts. Each project contains always a qualitative information survey (Part I) and a quantitative data survey (Part II). Part I surveys the structure of national systems applied to monitor and register individual occupational radiation exposures in each country involved in the project. The surveys of part II provide data for a comparable overview over the exposure of radiation workers in the European countries. It was the aim of ESOREX 2005 to cover a ten-years time series of the calendar years 1995 to 2004. A special web site has been in preparation and currently awaits EC approval to publish all collected data and results. Some general information are already available on the address www.esorex.eu. Based on the data and information collected in ESOREX for 1996 - 2004 (2005) we can give a first valuable assessment of dose trends for radiation workers in different work sectors in Europe for last ten years. The first evaluation of the results shows that the number of workers increased from app. 1,030 millions up to 1,100 millions and the collective dose decreased from 564 manSv to 407 manSv. This situation leads of course also to the decreasing of the average doses for workers from 0,55mSv to 0,37mSv resp. from 1,54 mSv to 1,21 mSv for those with doses higher that 0 mSv (resp. MDL). The form of the available data from the different European countries is not still standardized. However many countries during this survey developed their own system of the national central register and what could be seen as positive they used also ESOREX platform for the sharing of the information about the systems and structures of the registers operated in other countries. This is good beginning for the establishment of the sustainable platform

  7. The first decade: 2004 - 2014. 10 years of renewable energy progress

    The evolution of renewable energy over the past decade has surpassed all expectations. Global installed capacity and production from all renewable technologies have increased substantially, and supporting policies have continued to spread to more countries in all regions of the world. Developments in the early 2000's showed upward trends in global renewable energy investment, capacity, and integration across all sectors, yet most mainstream projections did not predict the extraordinary expansion of renewables that was to unfold over the decade ahead. Several factors set the foundation for this rapid growth. The various energy crises-beginning in the 1970's - and the subsequent economic downturns underscored the role of energy for both national and economic security. At the same time, a handful of pioneering countries-such as Germany, Denmark, Spain, and the United States-created critical markets for renewables, which drove early technological advances and economies of scale, setting the stage and helping to fuel the past decade of explosive market expansion. Growing emphasis on mitigating climate change and adapting to its impacts has further contributed to the momentum. Renewable energy's contribution to the global heat, power and transport sectors has increased steadily. While growth in renewable's share of total energy use has been moderated by increases in both population and world energy demand-most notably in developing and emerging economies-renewable energy markets and technology developments have accelerated quickly, even when compared to other rapidly developing technologies such as mobile phones. Although the last decade has seen tremendous advances in the electricity sector, the renewable heating and cooling sector has lagged behind. This is despite the marked growth since 2004 in the use of geothermal, solar thermal, and biomass heating technologies for water and space heating, process heat, and cooling. Given that the share of

  8. The effect of radiological hip dysplasia and breed on survival in a prospective cohort study of four large dog breeds followed over a 10 year period.

    Krontveit, Randi I; Trangerud, Cathrine; Nødtvedt, Ane; Dohoo, Ian; Moe, Lars; Sævik, Bente K

    2012-07-01

    The aim of the study was to measure the effect of radiological hip and elbow dysplasia status and breed on overall survival in a cohort of four large dog breeds in Norway. Privately owned dogs of the Newfoundland (NF), Labrador Retriever (LR), Leonberger (LEO), and Irish Wolfhound (IW) breeds were followed prospectively from birth to 10 years of age. The age of death/euthanasia was registered. A total of 501 dogs from 103 litters were enrolled. Kaplan-Meier survival curves were used to describe breed differences in survival times. The effects of radiological hip and elbow dysplasia status as well as breed were assessed using a Cox proportional hazards model. The variables 'sex' and 'living region' were explored as potential confounders. Among LRs, 60.2% of the dogs were still alive at 10 years of age, and the corresponding figures for NFs, LEOs, and IWs were 28.8%, 16.11%, and 6.4%, respectively. Radiological hip dysplasia status and breed were found to influence overall survival. Two different time-varying effects were observed in that with the IW the hazard of death increased linearly through time, while the effect of severe radiological hip dysplasia decreased logarithmically with time. Location influenced the death hazard and dogs living in suburban areas or cities had longer mean time to death and a lower hazard compared to dogs living in the countryside. Radiological elbow dysplasia status was not found to have an effect on overall survival. PMID:22093911

  9. Caries prevalence and enamel defects in 5- and 10-year-old children with cleft lip and/or palate

    Sundell, Anna Lena; Nilsson, Anna-Karin; Ullbro, Christer;

    2016-01-01

    OBJECTIVE: To determine the prevalence of dental caries and enamel defects in 5- and 10-year-old Swedish children with cleft lip and/or palate (CL(P)) in comparison to non-cleft controls. MATERIALS AND METHODS: The study group consisted of 139 children with CL(P) (80 subjects aged 5 years and 59...... prevalence of enamel defects was found in CL(P) children of both age groups and anterior permanent teeth were most commonly affected. CONCLUSIONS: Preschool children with cleft lip and/or palate seem to have more caries in the primary dentition than age-matched non-cleft controls. Enamel defects were more...... aged 10 years) and 313 age-matched non-cleft controls. All children were examined by one of two calibrated examiners. Caries was scored according to the International Caries Detection and Assessment System (ICDAS-II) and enamel defects as presence and frequency of hypoplasia and hypomineralization...

  10. Absorbed radiation dose in plants of natural complexes in Belarus over the past 10 years following the Chernobyl accident

    An absorbed radiation dose in plant of the natural complexes in Belarus for 10 years following the Chernobyl accident was calculated. The data on dynamics of the exposure dose rate in the area for 10 years were used for calculating the absorbed dose due to external irradiation and the data on the specific activity of the plants due to incorporation of cesium 137 and strontium 90 were taken into consideration when calculating the absorbed dose due to internal irradiation. Maximal absorbed doses in plants (to 40 Gy) were fixed in the zone with the high density of contamination. It resulted in visible somatic damages of separated plant organs. The highest contribution to formation of absorbed doses of ionizing radiation in plants in the contaminated zones belongs to internal irradiation of plant organisms due to incorporated radionuclides, in particular cesium 137

  11. A Randomized 10-year Prospective Follow-up of Class II Nanohybrid and Conventional Hybrid Resin Composite Restorations

    van Dijken, Jan Wv; Pallesen, Ulla

    2014-01-01

    Purpose: To evaluate the 10-year durability of a nanohybrid resin composite in Class II restorations in a randomized controlled intraindividual comparison with its conventional hybrid resin composite predecessor. Materials and Methods: Each of 52 participants received at least two Class II...... restorations that were as similar as possible. The cavities were chosen at random to be restored with a nanohybrid resin composite (Excite/Tetric EvoCeram (TEC); n = 61) and a conventional hybrid (Excite/Tetric Ceram (TC); n = 61). The restorations were evaluated with slightly modified USPHS criteria at...... baseline and then annually for 10 years. The overall performance of the experimental restorations was tested after intra-individual comparison and their ranking was tested using Friedman's two-way ANOVA. The level of significance was set at 5%. Results: Four patient drop-outs with 8 restorations (4TEC, 4TC...

  12. CRESESB: 10 years of activities aimed at the future; CRESESB - 10 anos de atividades visando o futuro

    Galdino, Marco Antonio; Souza, Hamilton Moss de; Silva, Patricia de Castro da; Dutra, Ricardo Marques [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil). Dept. de Tecnologias Especiais], Emails: marcoag@cepel.br, moss@cepel.br, patricia@cepel.br, dutra@cepel.br

    2007-07-01

    The Centro de Referencia para as Energias Solar e Eolica Sergio de Salvo Brito - CRESESB was created in late 1994 through a agreement between CEPEL and the Ministry of Mines and Energy, at the recommendation of the 'Declaration of Belo Horizonte'. In 10 years of activities, CRESESB / CEPEL has developed several studies, the most important: support for various government programs of the MME and the MCT, Internet dissemination of information, assembling and running courses in solar energy and wind power, edition of publications, maintenance of a specialized library and visits to 'Casa Solar Eficiente' (Efficient Solar House). Other activities also include: attendance at meetings, participation in working groups, reporting, feasibility studies, installation and support of numerous events, etc.. The aim of this paper is to present the scientific community of solar and wind power a historical record of 10 years of activities developed by CRESESB, an assessment of achievements and planned targets for the future.

  13. Panic attacks 10 years after heart transplantation successfully treated with low-dose citalopram: a case report.

    Ye, Chenyu; Zhuang, Yamin; Ji, Jianlin; Chen, Hao

    2015-12-25

    Panic attacks are common among patients who have undergone heart transplantation, but there are no clinical guidelines for the treatment of panic attacks in this group of patients. This report describes a 22-year-old woman who experienced panic attacks 10 years after heart transplant surgery. The attacks started after she discovered that the average post-transplantation survival is 10 years. Treated with citalopram 10 mg/d, her symptoms improved significantly after 2 weeks and had completely resolved after 8 weeks. A positive physician-patient relationship with the doctors who regularly followed her medical condition was crucial to encouraging her to adhere to the treatment with citalopram. She continued taking the citalopram for 7 months without any adverse effects. When followed up 3 months after stopping the citalopram, she had had no recurrence of the panic attacks. PMID:27199531

  14. Deep Brain Stimulation of the Ventroposteromedial (VPM) Thalamus 10 Years after VPM Thalamotomy to Treat a Recurrent Facial Pain.

    Yamgoue, Yves; Pralong, Etienne; Levivier, Marc; Bloch, Jocelyne

    2016-01-01

    We report the successful treatment of recurrent facial pain by deep brain stimulation (DBS) of the ventroposteromedial thalamic nucleus (VPM-DBS), 10 years after VPM thalamotomy. A 62-year-old woman who suffered from an atypical right-sided trigeminal neuralgia of the V1 and V2 branches was successfully treated a decade ago with a radiofrequency VPM thermocoagulation. Ten years later, the same burning right-sided trigeminal pain progressively recurred and was resistant to medical treatments. A DBS procedure was proposed to the patient aiming to stimulate the vicinity of the preexisting stereotactic lesion. Intraoperatively, the pain relief was immediate at low stimulation intensities. Eleven months later, the patient remains pain free. This case report suggests that DBS targeting an area of the VPM close to the previous stereotactic lesion is possible as a salvage therapy, and can successfully achieve relief of facial pain 10 years after VPM thalamotomy. PMID:27096946

  15. Prevalence of cardiovascular risks factors and 10 year predictions of coronary heart disease in seafarers of Pertamina shipping (Indonesia)

    Purnawarma, Irwin GNI; Jensen, Olaf Chresten; Canals, ML;

    2011-01-01

    Background Cardiovascular disease is (CVD) is becoming a major health problem in the world and they have to be taken into account in shipping companies. Employees and Company management should be aware of the dangers and implications, CVD can bring. Objectives To obtain the prevalence of...... cardiovascular risk factors and to evaluate the 10 year prediction of Coronary Heart Disease in both seafarers and onshore workers at Pertamina Shipping. Methods This is a cross sectional study using data of periodical Medical Fitness Examinations in 2009 among 348 active male seafarers and onshore workers......, between ages of 40 - 55 years old working at Pertamina Shipping. A 10 year coronary risk is also evaluated and comparison of the risk is made between the two groups using Fisher's exact values. Results Assessment cardiovascular risk factors of 348 male seafarers and onshore worker were done. The dominant...

  16. Effect of 10 years of in vitro aging on the flexural properties of fiber-reinforced resin composites.

    Vallittu, Pekka K

    2007-01-01

    This study determined the effect of 10 years of water immersion on the properties of fiber-reinforced resin composites (FRC). E-glass and silica fibers were used to reinforce heat-cured and autopolymerized acrylic resin polymers. Control specimens were unreinforced. Test specimens stored in water for up to 10 years were tested by the 3-point test. The flexural strength and elasticity of the specimens decreased during water immersion (P E-glass FRC were 24% and 21%, respectively; for silica FRC, reductions were 47% and 46%, respectively; and for controls, reductions were 24% and 11%, respectively. E-glass FRC showed a smaller reduction in strength than silica FRC. PMID:17319361

  17. Allergy and risk of childhood acute lymphoblastic leukemia: a population-based and record-based study.

    Chang, Jeffrey S; Tsai, Yi-Wen; Tsai, Chia-Rung; Wiemels, Joseph L

    2012-12-01

    A deficit of normal immune stimulation in early childhood is a suspected risk factor for both childhood acute lymphoblastic leukemia (ALL) and allergies. The present study utilized a population-based case-control design using medical claims data from the National Health Insurance Research Database of Taiwan to evaluate the association between allergy and childhood leukemia. Eight hundred forty-six childhood ALL patients who were newly diagnosed during 2000 to 2008 and were older than 1 but less than 10 years of age were individually matched with 3,374 controls based on sex, birth date, and time of diagnosis (reference date for the controls). Conditional logistic regression was performed to assess the association between childhood ALL and allergies. An increased risk of ALL was observed with having an allergy less than 1 year before the case's ALL diagnosis (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.5, 2.0), more than 1 year before the case's diagnosis (OR = 1.3, 95% CI: 1.1, 1.5), and before the age of 1 year (OR = 1.4, 95% CI: 1.1, 1.7). These results suggest that the pathogenesis of childhood ALL and allergy share a common biologic mechanism. PMID:23171876

  18. A population-based cohort study of late mortality in adult autologous hematopoietic stem cell transplant recipients in Australia.

    Ashton, Lesley J; Le Marsney, Renate E; Dodds, Anthony J; Nivison-Smith, Ian; Wilcox, Leonie; O'Brien, Tracey A; Vajdic, Claire M

    2014-07-01

    We assessed overall and cause-specific mortality and risk factors for late mortality in a nation-wide population-based cohort of 4547 adult cancer patients who survived 2 or more years after receiving an autologous hematopoietic stem cell transplantation (HSCT) in Australia between 1992 and 2005. Deaths after HSCT were identified from the Australasian Bone Marrow Transplant Recipient Registry and through data linkage with the National Death Index. Overall, the survival probability was 56% at 10 years from HSCT, ranging from 34% for patients with multiple myeloma to 90% for patients with testicular cancer. Mortality rates moved closer to rates observed in the age- and sex-matched Australian general population over time but remained significantly increased 11 or more years from HSCT (standardized mortality ratio, 5.9). Although the proportion of deaths from nonrelapse causes increased over time, relapse remained the most frequent cause of death for all diagnoses, 10 or more years after autologous HSCT. Our findings show that prevention of disease recurrence remains 1 of the greatest challenges for autologous HSCT recipients, while the increasing rates of nonrelapse deaths due to the emergence of second cancers, circulatory diseases, and respiratory diseases highlight the long-term health issues faced by adult survivors of autologous HSCT. PMID:24631736

  19. A Rare Case of Femoral Neuropathy Associated with Ilio-Psoas Bursitis After 10 Years of Total Hip Arthroplasty

    Singh, Vivek; Shon, Won Yong; Lakhotia, Devendra; Kim, Jong Hoon; Kim, Tae Wan

    2015-01-01

    We describe a case of femoral nerve palsy caused due to non-infective large iliopsoas bursitis after 10 years of cementless ceramic-on-metal THA. Bursectomy and exploration of femoral nerve were done to relieve the compressive symptoms of femoral nerve. Patient neurological symptoms were recovered within six months. Iliopsoas bursitis after THA can lead to anterior hip pain, lump in inguinal area or abdomen, limb swelling due to venous compression or more rarely neurovascular compressive symp...

  20. Aging parents’ caregiving and rehabilitating a brain-injured son: an autoethnography of a 10-year journey

    Hassan, Syed Tajuddin Syed; Jamaludin, Husna

    2014-01-01

    This autoethnography withdraws from information accumulated through a 10-year period of daily-weekly-monthly descriptive observation-recording (triangulated- parents & house-helper) of caregiving and rehabilitating of our brain injured son (survivor/care-receiver). We present it as an interactive voice of verbal conversation, thoughts, insights, and interpretations. It is delivered as a series of articulation intra-pulsated with our interrogation of societal-cultural-religious perspectives, n...

  1. Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes

    Ksenija Limani; Fouad Aoun; Serge Holz; Marianne Paesmans; Alexandre Peltier; Roland van Velthoven

    2014-01-01

    Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4%) and 50 (46.3%) patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year act...

  2. Factors Associated with Overweight and Obesity among Kuwaiti Elementary Male School Children Aged 6–10 Years

    Abdulwahab Naser Al-Isa; Jennifer Campbell; Ediriweera Desapriya

    2010-01-01

    Background. Childhood obesity is becoming a global epidemic which may result in increased morbidity and mortality during young adulthood. Objectives. To identify factors associated with overweight and that of obesity among Kuwaiti elementary male school children aged 6–10 years. Methods. Weights and heights of 662 students at a randomly selected school were collected to obtain body mass index (BMI). Results. The prevalence of overweight and obesity among the students were 20.2% and 16.8%, res...

  3. Validity and Reliability of the TGMD-2 in 7-10-Year-Old Flemish Children with Intellectual Disability

    Simons, Johan; Daly, Daniel; Theodorou, Fani; Caron, Cindy; Simons, Joke; Andoniadou, Elena

    2008-01-01

    The purpose of this study was to assess validity and reliability of the TGMD-2 on Flemish children with intellectual disability. The total sample consisted of 99 children aged 7-10 years of which 67 were boys and 32 were girls. A factor analysis supported a two factor model of the TGMD-2. A low significant age effect was also found for the object…

  4. Physical efficiency of girls of 9-10 years in the process of physical training aimed at developing endurance

    Samokih I.I.

    2012-01-01

    Essence of specific of evaluation of physical capacity opens up in physical education of girls. In researches 45 girls took part in age 9-10 years. In a pedagogical experiment registered the indexes of physical development, physical preparedness, physical capacity. Expedience of the use of the offered method is grounded in physical education in schools. It is shown that in the process of double employments by a physical culture with priority implementation of exercises on endurance the level ...

  5. Metastatic Primary Signet Ring Cell Carcinoma of Rectum: A Case Report of 10-Year-old Male Child

    Singh, Kumkum; Singh, Amit; Bhutra, Shyam; Pachori, Geeta; Jangir, Mahesh Kumar

    2014-01-01

    Signet ring cell carcinomas of the colon and rectum are well documented in the adult population, but the incidence is very low in the paediatric population. Signet ring cell carcinoma has more malignant potential, mostly present as advanced stage and carries very poor prognosis. We are describing a 10-year-old male patient who presented with acute intestinal obstruction; radiology revealed large bowel obstruction and was diagnosed metastatic primary signet ring cell carcinoma of rectum on bio...

  6. Characteristics of the functional parameters of children of different somatotype during the period between 8 and 10 years

    Слюсарчук, Виктор Васильевич

    2011-01-01

    Studied the expression and change in functional parameters of the same girls and boys of different somatotypes between 8 and 10 years. In ascertaining experiment was attended by 80 girls and boys who at baseline was 8 years old. Found that girls and boys the same age but different somatotypes. They are similar trends: a high level of features to ensure aerobic metabolic reactions, higher aerobic and anaerobic capacity lower, below the required functionality to most of the studied systems. The...

  7. Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms

    Erickson, Kirk I.; Suever, Barbara L.; B. Magnus Francis; Kramer, Arthur F.

    2008-01-01

    Genetic variability in the dopaminergic and neurotrophic systems could contribute to age-related impairments in executive control and memory function. In this study we examined whether genetic polymorphisms for catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) were related to the trajectory of cognitive decline occurring over a 10-year period in older adults. A single-nucleotide polymorphism (SNP) in the COMT (Val158/108Met) gene affects the concentration of d...

  8. Chronic ulcerative gastroduodenitis as a first gastrointestinal manifestation of Hermansky-Pudlak syndrome in a 10-year-old child

    Lee, Anselm Chi-wai; Poon, Kin-Hung; Lo, Wing-Hong; Wong, Lap-Gate

    2008-01-01

    A 10-year-old Chinese boy who had a history of congenital thrombocytopathy presented with severe iron deficiency anemia secondary to chronic gastric inflammation and duodenal ulcerations. Subtle oculocutaneous albinism led to the finding of diminished dense bodies in the platelets under electron microscopy, hence the diagnosis of Hermansky-Pudlak syndrome (HPS). Biopsies from the stomach and duodenum revealed a lymphocytic infiltration in the submucosa, but H pylori infection was absent. The ...

  9. Associations between eating frequency, adiposity, diet, and activity in healthy weight and centrally obese children 9-10 years

    Jennings, A.; CASSIDY, A; van Sluijs, EMF; Griffin, SJ; Welch, AA

    2012-01-01

    The rising prevalence of childhood obesity is a key public health issue worldwide. Increased eating frequency (EF) is one aspect of diet that has been beneficially associated with obesity, although the mechanisms are unclear. The aims of the current study were to determine whether increased EF was associated with improved adiposity in children, and if this was due to differences in dietary and activity behaviours. Cross-sectional data from 1700 9-10-year-olds were analysed to examine associat...

  10. Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms

    Kirk I Erickson

    2008-09-01

    Full Text Available Genetic variability in the dopaminergic and neurotrophic systems could contribute to age-related impairments in executive control and memory function. In this study we examined whether genetic polymorphisms for catechol-O-methyltransferase (COMT and brain-derived neurotrophic factor (BDNF were related to the trajectory of cognitive decline occurring over a 10-year period in older adults. A single-nucleotide polymorphism (SNP in the COMT (Val158/108Met gene affects the concentration of dopamine in the prefrontal cortex. In addition, a Val/Met substitution in the pro-domain for BDNF (Val66Met affects the regulated secretion and trafficking of BDNF with Met carriers showing reduced secretion and poorer cognitive function. We found that impairments over the 10-year span on a task-switching paradigm did not vary as a function of the COMT polymorphism. However, for the BDNF polymorphism the Met carriers performed worse than Val homozygotes at the first testing session but only the Val homozygotes demonstrated a significant reduction in performance over the 10-year span. Our results argue that the COMT polymorphism does not affect the trajectory of age-related executive control decline, whereas the Val/Val polymorphism for BDNF may promote faster rates of cognitive decay in old age. These results are discussed in relation to the role of BDNF in senescence and the transforming impact of the Met allele on cognitive function in old age.

  11. Longitudinal study of growth of children with unilateral cleft lip and palate: 2 to 10 years of age.

    Marques, Ilza Lazarini; Nackashi, John; Borgo, Hilton Coimbra; Martinelli, Angela Patrícia Menezes Cardoso; de Souza, Luiz; Dutka, Jeniffer de Cássia Rillo; Williams, William N; Pegoraro-Krook, Maria Inês

    2015-03-01

    Objective : To study the growth of children with complete unilateral cleft lip and palate (UCLP) from 2 to 10 years of age and to assess whether growth varied from that of children without UCLP (typical children). Design : Physical growth was one of the outcome measures of a National Institutes of Health-sponsored longitudinal, prospective clinical trial conducted by the University of Florida and the University of São Paulo. Setting : Hospital of Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Bauru, Brazil. Main Outcome Measures : Height and weight were prospectively measured for 360 healthy children with UCLP who were nonsyndromic, belonged to median socioeconomic status, and received health care at HRAC-USP. To compare growth of children with UCLP to that of typical children, growth curves for UCLP were developed and compared with World Health Organization curves for 2006 and 2007, which were used as reference for typical children. Third-degree polynomials were used to explain the relationship of length and weight with age. Confidence limits of 95% were used for the mean curve using the statistic Z ~ N (0,1). Results : Children with UCLP from 2 to 10 years old presented height and weight growth curves similar to those of typical children for both genders. Conclusion : Children with UCLP from 2 to 10 years old presented physical growth similar to that of typical children. PMID:24810484

  12. Outcomes Following Iodine-125 Monotherapy for Localized Prostate Cancer: The Results of Leeds 10-Year Single-Center Brachytherapy Experience

    Purpose: This study reports the 10-year experience of permanent brachytherapy monotherapy at a single UK center. Methods and Materials: Between March 1995 and September 2004, 1,298 patients underwent trans-rectal ultrasound (TRUS) planned transperineal brachytherapy delivering 145 Gy using I-125. No patient received supplemental external beam; 44.2% received neoadjuvant hormones. In 688, CT postimplant dosimetry was available. Outcome data were analyzed in terms of overall survival (OS), disease specific survival (DSS), and PSA relapse-free survival (PSA-RFS). Results: The mean age was 62.9 (range, 34-83) years. Median follow-up was 4.9 years (range, 2.03-11.7 years). OS and DSS were 85% and 95%, respectively, at 10 years. Twenty-one patients died from prostate cancer (1.6%) and 34 (2.5%) from unrelated causes. Seventy-four (5.7%) developed evidence of clinical failure. Overall PSA-RFS was 79.9% and 72.1% at 10 years (American Society for Therapeutic Radiology and Oncology [ASTRO] and Nadir+2 definitions, respectively). Higher presenting PSA or Gleason score and use of neoadjuvant hormones were associated with an increased risk of biochemical failure (p 90 ≥140 Gy and in 78% of patients with D90 90 with biochemical control.

  13. Comparison of clinical features in surgical treatment of lung cancer over two 10-year periods in Shinshu University Hospital

    Lung cancer is one of the most common fatal cancers. We retrospectively evaluated 949 resected cases of lung cancer from January 1985 to December 2004 by comparative analysis of the first (1985-1994) and second 10-year period (1995-2004) with reference to patient age, gender, chief complaint, histological type, tumor differentiation, tumor size, operative method, pathological stage, and survival rate. Surgical treatment for patients older than 75 years of age doubled in the second 10-year period. CT health screenings indicating lung cancer increased. The percentage of well-differentiated adenocarcinoma increased in both males and females. Cases of tumors less than 20 mm, especially those less than 10 mm, increased in the second 10-year period. The ratio of pneumonectomy decreased, and limited resection including partial resection and segmentectomy increased. The number of cases in pathological stage IA increased. The 5-year survival rates in stages IA, IIIA, IV, and overall in the second period were statistically higher than in the first period. An age of 70 years of more, being male, first medical contact other than CT health screening, carotid endarterectomy (CEA) elevation, histological type other than well-differentiated adenocarcinoma, tumor size, lymph node metastasis, and pneumonectomy were all considered factors impacting survival in resected cases of lung cancer. (author)

  14. A population-based cohort study of chest x-ray screening in smokers: lung cancer detection findings and follow-up

    Case-control studies of mass screening for lung cancer (LC) by chest x-rays (CXR) performed in the 1990s in scarcely defined Japanese target populations indicated significant mortality reductions, but these results are yet to be confirmed in western countries. To ascertain whether CXR screening decreases LC mortality at community level, we studied a clearly defined population-based cohort of smokers invited to screening. We present here the LC detection results and the 10-year survival rates. The cohort of all smokers of > 10 pack-years resident in 50 communities of Varese, screening-eligible (n = 5,815), in July 1997 was invited to nonrandomized CXR screening. Self-selected participants (21% of cohort) underwent screening in addition to usual care; nonparticipants received usual care. The cohort was followed-up until December 2010. Kaplan-Meier LC-specific survival was estimated in participants, in nonparticipants, in the whole cohort, and in an uninvited, unscreened population (control group). Over the initial 9.5 years of study, 67 LCs were diagnosed in screening participants (51% were screen-detected) and 178 in nonparticipants. The rates of stage I LC, resectability and 5-year survival were nearly twice as high in participants (32% stage I; 48% resected; 30.5% 5-year survival) as in nonparticipants (17% stage I; 27% resected; 13.5% 5-year survival). There were no bronchioloalveolar carcinomas among screen-detected cancers, and median volume doubling time of incidence screen-detected LCs was 80 days (range, 44-318), suggesting that screening overdiagnosis was minimal. The 10-year LC-specific survival was greater in screening participants than in nonparticipants (log-rank, p = 0.005), and greater in the whole cohort invited to screening than in the control group (log-rank, p = 0.001). This favourable long-term effect was independently related to CXR screening exposure. In the setting of CXR screening offered to a population-based cohort of smokers, screening

  15. 10 years of Ws

    Ten years ago, on 25 January 1983, the discovery of the W particle at CERN's proton-antiproton collider was announced to the world. The W, the electrically charged carrier of the weak nuclear force, had been predicted 24 years earlier in the classic formulations of modern weak interaction theory by Feynman and Gell- Mann and by Marshak and Sudarshan, and went on to play an important role in the subsequent electroweak unification of electromagnetism and the weak nuclear force. Following the discovery of the neutral current at CERN in 1973, it became clear that the W was an extremely heavy particle, some 80 times heavier than the proton, too heavy to be detected by any accelerator in operation at the time. Pushed by Carlo Rubbia, the CERN proton-antiproton collider was built to find the W and its electrically neutral companion, the Z. Collider operations at CERN in 1982 had been compressed into a two month run, from October to December. The teams at the big UA1 and UA2 experiments eagerly sifting through their 1982 data noticed the first signs of Ws. The initial candidate W events were announced in CERN seminars by Carlo Rubbia, for UA1, on 20 January 1983*, and the following day by Luigi Di Leila for UA2. As well as new science, these two seminars also set a trend for packing the CERN auditorium to overflowing

  16. ENLIGHT 10 year Anniversary

    Alvarez, Paul

    2012-01-01

    Ten years ago, in February 2002, the European Network for Light Ion Hadron Therapy (ENLIGHT) had its inaugural meeting at CERN. As a pioneering multidisciplinary network celebrates its 10th anniversary, some of the founders recall how it all started. Picture 1 : Participants at the 10th anniversary meeting of ENLIGHT at CNAO, Pavia, in September 2012.

  17. The natural history of local regional breast cancer recurrence: prognosis and implications for systemic therapy

    Purpose: The purpose of this study is to determine the natural history and long term outcome of breast cancer patients sustaining local regional failure as their first site of relapse in an effort to design a prospective study evaluating systemic therapy at the time of local regional relapse. Materials and Methods: Between January 1970 and December 1992, over 4000 patients with a diagnosis of breast cancer were treated at our facilities with mastectomy or conservative surgery with radiation therapy (CS+RT). A total of 195 patients sustained a local regional relapse, without evidence of distant metastasis, as the first site of failure and serve as the population base for this study. The 195 patients with local-regional recurrence of disease were distributed as follows: 59 patients relapsed in the ipsilateral breast following CS+RT within 5 years of original diagnosis (EARLYBR); 45 patients relapsed in the ipsilateral breast >5 years from original diagnosis (LATEBR); 52 patients relapsed in the chest wall following mastectomy (CWREC); and 23 patients failed in the regional lymphatics following mastectomy or CS+RT (REGREC). Patients with EARLYBR or LATEBR were generally treated with salvage mastectomy and patients with CWREC or REGREC were treated with definitive irradiation to the chest wall and/or regional nodes. Systemic therapy at the time of locoregional relapse was highly individualized, ranging from observation to tamoxifen to high dose chemotherapy with transplantation. Patient charts were reviewed with all clinical, pathologic, treatment, and outcome parameters entered onto a computerized database. Survival curves were calculated using the life table method with differences between survival curves compared by the Mantle-Haensel statistic. Survival, disease-free survival and distant metastasis rates were calculated from the date of original diagnosis, as well as from the date of local regional relapse. Local regional recurrence-free time was calculated from

  18. Numerical transcoding proficiency in 10-year-old schoolchildren is associated with grey-matter interindividual differences: A voxel-based morphometry study

    Amélie eLubin

    2013-04-01

    Full Text Available Are individual differences in numerical performance sustained by variations in grey matter volume in schoolchildren? To our knowledge, this challenging question for neuroeducation has not yet been investigated in typical development. We used the Voxel-Based Morphometry method to search for possible structural brain differences between two groups of 10-year-old schoolchildren (N=22 whose performance differed only in numerical transcoding between analog and symbolic systems. The results indicated that children with low numerical proficiency have less grey matter volume in the parietal (particularly in the left intraparietal sulcus and the bilateral angular gyri and occipito-temporal areas. All the identified regions have previously been shown to be functionally involved in transcoding between analog and symbolic numerical systems. Our data contribute to a better understanding of the intertwined relationships between mathematics learning and brain structure in healthy schoolchildren.

  19. Numerical Transcoding Proficiency in 10-Year-Old Schoolchildren is Associated with Gray Matter Inter-Individual Differences: A Voxel-Based Morphometry Study.

    Lubin, Amélie; Rossi, Sandrine; Simon, Grégory; Lanoë, Céline; Leroux, Gaëlle; Poirel, Nicolas; Pineau, Arlette; Houdé, Olivier

    2013-01-01

    Are individual differences in numerical performance sustained by variations in gray matter volume in schoolchildren? To our knowledge, this challenging question for neuroeducation has not yet been investigated in typical development. We used the Voxel-Based Morphometry method to search for possible structural brain differences between two groups of 10-year-old schoolchildren (N = 22) whose performance differed only in numerical transcoding between analog and symbolic systems. The results indicated that children with low numerical proficiency have less gray matter volume in the parietal (particularly in the left intraparietal sulcus and the bilateral angular gyri) and occipito-temporal areas. All the identified regions have previously been shown to be functionally involved in transcoding between analog and symbolic numerical systems. Our data contribute to a better understanding of the intertwined relationships between mathematics learning and brain structure in healthy schoolchildren. PMID:23630510

  20. Survival trends in metastatic bladder cancer in the United States: A population based study

    Binay Kumar Shah

    2015-01-01

    Conclusions: This population-based study shows that decreases in 6-month and 12-month relative survival rates among patients with MBC in 2001-2010 compared to 1991-2000, specifically, more pronounced among CC men and Oth men.

  1. Determinants of successful implementation of population-based cancer screening programmes

    Lynge, Elsebeth; Törnberg, Sven; von Karsa, Lawrence; Segnan, Nereo; van Delden, Johannes J M

    2012-01-01

    To facilitate the future implementation of population-based cancer screening programmes in European countries, we summarised the experience gained from existing programmes across Europe. We listed points that citizens, advocacy groups, politicians, health planners, and health professionals should...

  2. Dynamic statistics on radiology-related examinations of the department of dental radiology at the Kyushu Dental College Hospital during the past 10 years

    We have reported dynamic statistics on radiology-related examinations and patients in our department every 10 years in order to clarify the role and characteristics of the Department of Dental Radiology at the Kyushu Dental College Hospital. In the last 10 years, the latest models of X-ray CT and magnetic resonance imaging (MRI) equipment have been used, as they were installed when the newly built Kyushu Dental College hospital was opened in September 1999. Therefore, we can now treat more types of disease in the soft tissues of the oral and maxillofacial regions than before. In the present study, we examined the precise numbers of radiology-related examinations and patients, and analyzed the purpose of radiology-related examinations in each modality. Plain radiography, X-ray CT scanning, MRI and ultrasonography were performed at our department from April 1, 1995 to March 31, 2007, and were analyzed for examination number and purpose. The results were as follows. The number of patients visiting our hospital and our department increased markedly when the newly built hospital was opened 10 years ago. The annual number of imaging examinations during the same period also increased substantially. However, the annual number of patients has remained relatively constant since the initial increase. There is an apparent relationship between the number of outpatients and the number of imaging examinations. Because our department began to offer MRI examinations in September 1999, the frequency of these examinations has increased annually for the purpose of soft tissue-related diseases in the oral and maxillofacial regions. X-ray CT examination was mainly used for the detection of diseases occurring in the maxilla and mandible, or of calcification-related diseases such as sialolithiasis. On the other hand, the purpose of MRI examination was the precise detection of diseases occurring in the soft tissues, such as salivary glands. The results suggest that the dentists in our

  3. Heritability of neck pain: a population-based study of 33,794 Danish twins

    Fejer, R; Hartvigsen, J; Kyvik, K O

    2006-01-01

    OBJECTIVES: To determine the heritability of neck pain in a large population-based study of twins. METHODS: Data on lifetime prevalence of neck pain from a population-based cross-sectional survey of Danish twins were used. To assess twin similarity, the probandwise concordance rates, zygosity...... gradually less important with increasing age, and environmental factors dominate almost completely in the older age groups....

  4. Longitudinal population-based studies of affective disorders: Where to from here?

    Beard John R; Galea Sandro; Vlahov David

    2008-01-01

    Abstract Background Longitudinal, population-based, research is important if we are to better characterize the lifetime patterns and determinants of affective disorders. While studies of this type are becoming increasingly prevalent, there has been little discussion about the limitations of the methods commonly used. Methods Discussion paper including a brief review of key prospective population-based studies as the basis for a critical appraisal of current approaches. Results We identified a...

  5. The protocols for the 10/66 dementia research group population-based research programme

    Salas Aquiles; de Rodriguez Juan; McKeigue Paul; Jacob KS; Krishnamoorthy ES; Huang Yueqin; Guerra Mariella; Gavrilova Svetlana I; Dewey Michael; Arizaga Raul; Albanese Emiliano; Acosta Daisy; Ferri Cleusa P; Prince Martin; Sosa Ana

    2007-01-01

    Abstract Background Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with dementia that live in developing countries and the less than one tenth of population-based research carried out in those settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress this imbalance. Meth...

  6. Perceived weight discrimination in England: a population-based study of adults aged >50 years.

    Jackson, S.E.; STEPTOE, A; Beeken, R. J.; Croker, H.; Wardle, J.

    2014-01-01

    Background:Despite a wealth of experimental studies on weight bias, little is known about weight discrimination at the population level. This study examined the prevalence and socio-demographic correlates of perceived weight discrimination in a large population-based sample of older adults.Methods:Data were from 5307 adults in the English Longitudinal Study of Ageing; a population-based cohort of men and women aged ⩾50 years. Weight discrimination was reported for five domains (less respect/c...

  7. Education status determines 10-year (2002-2012) survival from cardiovascular disease in Athens metropolitan area: the ATTICA study, Greece.

    Panagiotakos, Demosthenes; Georgousopoulou, Ekavi; Notara, Venetia; Pitaraki, Evangelia; Kokkou, Eleni; Chrysohoou, Christina; Skoumas, Yannis; Metaxa, Vassiliki; Pitsavos, Christos; Stefanadis, Christodoulos

    2016-05-01

    Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, and educational level seems to be an important determinant of the disease occurrence. The aim of this work was to investigate the association between education status and 10-year incidence of CVD, controlling for various socio-demographic lifestyle and clinical factors. From May 2001 to December 2002, 1514 men and 1528 women (>18 years) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. Education status was measured in years of schooling. The 10-year incidence of CVD was 15.7% [95% confidence intervals (CI) 14.1%-17.4%], 19.7% in men and 11.7% in women (Pgender 12 years of schooling). People in the low education group had higher prevalence of hypertension, diabetes and dyslipidaemias, were more likely to be smokers and sedentary, had less healthy dietary habits, as compared with those in the high education group. When controlling for participants' medical history, smoking, dietary and lifestyle habits, low education was no longer significantly associated with CVD, illustrating the mediating effect of clinical and behavioural factors in the link between education and disease. It was of interest that low education status interacted with alcohol drinking, enhancing the adverse effect of low education on CVD risk (relative risk 1.44, 95% CI 0.94%-2.20%), after various adjustments made. In this study, it was concluded that low educational level was associated with increased CVD risk. This was mainly explained by the intermediate association of low education with unhealthy choices that consequently worsen clinical status. PMID:25754715

  8. Long Term Clinical Prognostic Factors in Relapsing-Remitting Multiple Sclerosis: Insights from a 10-Year Observational Study.

    Gabriel Bsteh

    Full Text Available Multiple sclerosis (MS has a highly heterogenic course making prediction of long term outcome very difficult.The objective was to evaluate current and identify additional clinical factors that are linked to long term outcome of relapsing-remitting MS assessed by disability status 10 years after disease onset.This observational study included 793 patients with relapsing-remitting MS. Clinical factors hypothesized to influence long term outcome measured by EDSS scores 10 years after disease onset were analysed by Kaplan-Meier-estimates. Multinomial logistic regression models regarding mild (EDSS ≤2.5, moderate (EDSS 3.0-5.5 or severe (EDSS ≥6.0 disability were calculated to correct for confounders.Secondary progression was the strongest predictor of severe disability (Hazard ratio [HR] 503.8, 95% confidence interval [CI] 160.0-1580.1; p<0.001. Complete remission of neurological symptoms at onset reduced the risk of moderate disability (HR 0.42; CI 0.23-0.77; p = 0.005, while depression (HR 3.59; CI 1.14-11.24; p = 0.028 and cognitive dysfunction (HR 4.64; CI 1.11-19.50; p = 0.036 10 years after disease onset were associated with severe disability. Oligoclonal bands and pregnancy were not correlated with disability.We were able to identify clinically apparent chronic depression and cognitive dysfunction to be associated with adverse long term outcome in MS and to confirm that pregnancy has no negative impact. Additionally, we emphasize the positive predictive value of complete remission of initial symptoms.

  9. Seal, replacement or monitoring amalgam restorations with occlusal marginal defects? Results of a 10-year clinical trial.

    Moncada, G; Fernández, E; Mena, K; Martin, J; Vildósola, P; De Oliveira Junior, O B; Estay, J; Mjör, I A; Gordan, V V

    2015-11-01

    The aim of this prospective and blind clinical trial was to assess the effectiveness of sealing localized marginal defects of amalgam restoration that were initially scheduled to be replaced. A cohort of twenty six patients with 60 amalgam restorations (n=44Class I and n=16Class II), that presented marginal defects deviating from ideal (Bravo) according to USPHS criteria, were assigned to either sealing or replacement groups: A: sealing n=20, Replacement n=20, and no treatment (n=20). Two blind examiners evaluated the restorations at baseline (K=0.74) and after ten years (K=0.84) according with USPHS criteria, in four parameters: marginal adaptation (MA), secondary caries (SC), marginal staining (MS) and teeth sensitivity (TS). Multiple comparison of restorations degradation/upgrade was analyzed by Friedman test and the comparisons within groups were performed by Wilcoxon test. After 10 years, 44 restorations were assessed (73.3%), Group A: n=14 and Group B: n=16; and Group C: n=14 sealing and replacement amalgam restorations presented similar level of quality in MA (p=0.76), SC (p=0.25) and TS (p=0.52), while in MS (p=0.007) presented better performance in replacement group after 10-years. Most of the occlusal amalgam restorations with marginal gaps showed similar long term outcomes than the restorations were sealed, replaced, or not treated over a 10-year period. Most of the restorations of the three groups were clinically acceptable, under the studied parameters. All restorations had the tendency to present downgrade/deterioration over time. PMID:26231302

  10. Role of collateral circulation in the course of coronary heat disease (10-year clinical and angiographic follow-up)

    Results of the 10-year prospective follow-up of 59 ischemia patients with stenocardia are presented. Coronarography was made in all the patients whose coronary arteries and collateral blood flow were assessed. The experimental group comprised 37 patients with ischemia and collateral circulatory insufficiency. The control group included 22 patients with effective collateral circulation. The experimental group showed a worse prognosis than did the control one. Myocardial infarction developed in 54 and 27 % of cases, ischemia mortality was 29.7 and 9 % in the experimental and control groups, respectively. Effective collateral circulation is prerequisite of successful surgical myocardial revascularization

  11. [Renal adenocarcinoma in a two and a half year old child: Diagnosis, therapeutic management and 10-year followup].

    Pires, Christophe; Irani, Jacques; Ouaki, Frédéric; Dahmani, Laurent; Doré, Bertrand

    2002-09-01

    Renal cell carcinoma is a rare tumour in children and is difficult to diagnose, often leading to inappropriate primary treatment with chemotherapy in Europe. The incidence of renal cell carcinoma is much lower than that of Wilms tumour. These two types can be associated, in which case Wilms tumour is the predominant tumour. However, pure renal cell carcinoma remains an exceptional tumour in children and appears to present an identical natural history and follow-up as in adults. The authors report the case of a two and a half year old child treated by surgery alone with a follow-up of 10 years without recurrence. PMID:12463133

  12. Pet ownership, dog types and attachment to pets in 9–10 year old children in Liverpool, UK

    Westgarth, Carri; Boddy, Lynne M; Stratton, Gareth; German, Alexander J.; Gaskell, Rosalind M.; Coyne, Karen P; Bundred, Peter; McCune, Sandra; Dawson, Susan

    2013-01-01

    Background Little is known about ethnic, cultural and socioeconomic differences in childhood ownership and attitudes to pets. The objective of this study was to describe the factors associated with living with different pet types, as well as factors that may influence the intensity of relationship or ‘attachment’ that children have to their pet. Data were collected using a survey of 1021 9–10 year old primary school children in a deprived area of the city of Liverpool, UK. Results Dogs were t...

  13. Multimodality imaging of a subtotally obstructive right ventricular myxoma in an asymptomatic 10-year-old girl

    Gesa Wiegand

    2014-01-01

    Full Text Available A 10-year-old girl presented with a supraventricular tachycardia. A heart murmur was detected during a clinical examination; therefore, echocardiography was performed. This revealed a giant right ventricular myxoma that subtotally obstructed the right ventricular outflow tract. A myxoma in the right ventricle is uncommon in children. This rare intracardiac tumor was examined using multimodality imaging, and the patient underwent surgical resection. The pathologic features confirmed our suspicion and revealed an encapsulated tumor with myxomatoid stroma containing focal hemorrhages.

  14. Physical efficiency of girls of 9-10 years in the process of physical training aimed at developing endurance

    Samokih I.I.

    2012-01-01

    Full Text Available Essence of specific of evaluation of physical capacity opens up in physical education of girls. In researches 45 girls took part in age 9-10 years. In a pedagogical experiment registered the indexes of physical development, physical preparedness, physical capacity. Expedience of the use of the offered method is grounded in physical education in schools. It is shown that in the process of double employments by a physical culture with priority implementation of exercises on endurance the level of physical capacity of schoolgirls rises considerably. Directions of prognostication of the state of physical health of schoolboys and correction of process of physical education are recommended at school.

  15. Whole clavicle sequestration from chronic osteomyelitis in a 10 year old boy: A case report and review of the literature

    Agu Thaddeus Chika; Ojiaku Mathew Emeka

    2016-01-01

    Chronic osteomyelitis is a childhood disease and so it is not uncommon to diagnose it in a 10 year old boy who is suffering from pains and discharging sinuses from the left shoulder girdle. What is not common is the involvement of the clavicle in this infective process and even more uncommon is for the whole length of the clavicle to sequester. This case report describes a rare case of chronic osteomyelitis of the left clavicle in which the entire length was removed as a sequestrum during sur...

  16. 10-year Incidence of Diabetes and Associated Risk Factors in Greece: the ATTICA study (2002-2012)

    Koloverou, Efi; Panagiotakos, Demosthenes B.; Pitsavos, Christos; Chrysohoou, Christina; Georgousopoulou, Ekavi N.; Pitaraki, Evangelia; Metaxa, Vassiliki; Stefanadis, Christodoulos

    2014-01-01

    BACKGROUND: The incidence of diabetes in the general population is increasing world-wide. The increase is attributed to the consumption of saturated fatty acids, obesity, lack of physical activity, genetic predisposition, and other factors, but knowledge about the reasons, biological mechanisms, and late complications is insufficient. It is therefore important to clarify the reasons more exactly through long-term clinical trials to stop the rise of diabetes and its complications. AIM: To evaluate the 10-year incidence of type 2 diabetes in apparently healthy Greek adults. METHODS: In 2001-2002, a random sample of 1514 men (18-87 years old) and 1528 women (18-89 years old) was selected to participate in the ATTICA study. During 2011-2012, the 10-year follow-up was performed. Patients diagnosed with diabetes at baseline (n = 210) and those lost at the 10-year follow-up (n = 1347) were excluded, yielding a final sample of 1485 participants. RESULTS: During the period of investigation, diabetes was diagnosed in 191 cases corresponding to a 12.9% incidence (95%CI: 10.4-15.4), with 13.4% (95%CI: 10.8-16) in men and 12.4% (95%CI: 10.1-14.7) in women. A relative increase was observed in the second half of the 10-year follow-up when age became significant. Multiple logistic regression analysis revealed that age (OR = 1.14, 95%CI: 1.09-1.19), abnormal waist-to-height ratio (OR = 3.27, 95%CI: 1.07-10.0), fasting blood glucose (OR per 1 mg/dl = 0.05, 95%CI: 1.02-1.08), energy intake (OR per 500 kcal = 1.02, 95%CI: 1.01-1.35), and family history of diabetes (OR = 2.8, 95%CI: 1.30-6.03) were the most significant baseline predictors for diabetes, after adjusting for potential confounders. Waist-to-height ratio showed the best explanatory power of all anthropometric variables. Physical activity exerts an effect on risk factors. Being active was found to eliminate the aggravating effect of diabetes family history and fasting blood glucose. CONCLUSIONS: The findings confirm the

  17. Ophthalmic experience over 10 years in an observational nationwide Danish cohort of Fabry patients with access to enzyme replacement

    Fledelius, Hans C.; Sandfeld, Lisbeth; Rasmussen, Åse Krogh;

    2015-01-01

    PURPOSE: Enzyme replacement therapy (ERT) was offered from year 2001 to patients with Fabry disease. The ophthalmic experience was analysed, as part of a general 10-year status. METHODS: A retrospective observational series comprising 39 patients (25 females, 14 males) closely followed by the...... endocrinologists, and with regular ophthalmic control. Time of inclusion was when the option of ERT was started, at age 11-60 years. Eye data (standard eye examination, including retinal imaging) were incomplete in five, due to death or non-attendance, and five patients had refused treatment. RESULTS: Vision was...

  18. Risk of Parkinson Disease in Diabetes Mellitus: An Updated Meta-Analysis of Population-Based Cohort Studies

    Yue, Xuejing; Li, Hehua; Yan, Haiqing; Zhang, Ping; Chang, Li; Li, Tong

    2016-01-01

    Abstract Previous meta-analysis has identified the associations between diabetes mellitus (DM) and the risk of Parkinson disease (PD). However, the results are still debatable. The purpose of this study is to perform an updated meta-analysis to investigate the up-to-date pooling evidence based on published population-based cohort studies and assess the association between DM and the risk of PD. Electronic database including Pubmed and Embase were searched to identify cohort studies published before October, 2015. Studies were selected if they reported the risk estimates for PD associated with DM. We pooled the adjusted effect estimates using random-effects meta-analysis. Funnel plot, Begg, or Egger test as well as Duval and Tweedie trim-and-fill approach were applied to assess publication bias. A total of 7 population-based cohort studies, representing 1,761,632 individuals were included in the meta-analysis. The pooled adjusted relative risk (RR) of PD associated with DM was 1.38 (95% CI 1.18–1.62, P < 0.001). An effect was consistent in female (RR 1.50 95% CI 1.07–2.11, P = 0.019) and in male (RR 1.40, 95% CI 1.17–1.67). The association was similar when stratified by study quality, research region, study design, sample size, published year, diabetes duration, and baseline age. The trim-and-fill approach confirmed the robutness of the result (RR 1.31, 95% CI 1.09–1.57, P = 0.015). Our findings based on population-based cohort studies indicate that diabetes is associated with increased PD risk by about 38%. More large-scale prospective studies are warranted to further clarify this association and its mechanism. PMID:27149468

  19. Prevalence of hepatitis A antibodies in Eastern Bolivia: a population-based study.

    C, Masuet-Aumatell; J M, Ramon-Torrell; A, Casanova-Rituerto; M, Banqué-Navarro; M, Dávalos-Gamboa; S L, Montaño-Rodríguez

    2013-10-01

    The seroprevalence of hepatitis A virus (HAV) is changing from high to intermediate endemicity in several Latin American countries, but the pattern in the Andean Latin American countries is unknown. A seroepidemiological survey (n = 436) of HAV in schoolchildren living in the Cochabamba region of Bolivia was conducted in 2010. A questionnaire was completed by parents to obtain demographic, socio-economic, and housing data, and blood samples were collected. The overall prevalence of HAV IgG was 95.4% (95% CI 93.5-97.4). The prevalence was higher in children aged 5-10 years (97%) and pre-adolescents aged 10-13 years (97.9%). The prevalence was also higher in subjects whose parents had a low level of education (99.4-99.5%), who lived in rural areas (98.7%), lived in municipalities with low urban development (99.1-100%), had water delivered at home from a tanker (99.4%), and spoke Quechua at home (99.5%). The descriptive and bivariate analysis suggested that no change in HAV epidemiology has occurred in Cochabamba. PMID:23861034

  20. Reproducibility and Relative Validity of a Short Food Frequency Questionnaire in 9–10 Year-Old Children

    Pouya Saeedi

    2016-05-01

    Full Text Available The aim of this study was to assess the reproducibility and validity of a non-quantitative 28-item food frequency questionnaire (FFQ. Children aged 9–10 years (n = 50 from three schools in Dunedin, New Zealand, completed the FFQ twice and a four-day estimated food diary (4DEFD over a two-week period. Intraclass correlation coefficients (ICC and Spearman’s correlation coefficients (SCC were used to determine reproducibility and validity of the FFQ, respectively. Weekly intakes were estimated for each food item and aggregated into 23 food items/groups. More than half of the food items/groups (52.2% had an ICC ≥0.5. The median SCC between FFQ administrations was 0.66 (ranging from 0.40 for processed meat to 0.82 for sweets and non-dairy drinks. Cross-classification analysis between the first FFQ and 4DEFD for ranking participants into thirds showed that breakfast cereals had the highest agreement (54.0% and pasta the lowest (34.0%. In validity analyses, 70% of food items/groups had a SCC ≥0.3. Results indicate that the FFQ is a useful tool for ranking children according to food items/groups intake. The low respondent burden and relative simplicity of the FFQ makes it suitable for use in large cohort studies of 9–10 year-old children in New Zealand.

  1. Arterial reconstruction of the brachiocephalic trunk and the subclavian arteries. 10 years' experience with a follow-up study

    Schroeder, T; Hansen, Hans Jørgen Buchardt

    1980-01-01

    During a 10-year period, 60 patients were operated on for occlusive lesions in the brachiocephalic trunk and/or the subclavian arteries proximal to the vertebral artery. Angiography showed 68 occlusive lesions, of which 64 were treated surgically. Of these, 47 exhibited subclavian steal. Sixty-th...... three per cent worsened. Twice as many patients could work after the operation as before. The cumulative survival rate was found to be somewhat lower than that of a normal population.......During a 10-year period, 60 patients were operated on for occlusive lesions in the brachiocephalic trunk and/or the subclavian arteries proximal to the vertebral artery. Angiography showed 68 occlusive lesions, of which 64 were treated surgically. Of these, 47 exhibited subclavian steal. Sixty......-three reconstructive procedures were performed together with two arterial ligations (four patients were operated on bilaterally and one patient was operated on twice on the same side). There were 30 transthoracic procedures, essentially endarterectomies, and 35 supraclavicular procedures, mostly carotid...

  2. ARABELLE 1550 MWe units: 10 years of feedback experience in the EDF N4 nuclear power plants

    The purpose of this paper is to describe the feedback experience of the main turbo-machines of the ARABELLE technology after 10 years of operation in the EDF N4 Nuclear Power Plants. The main specificity of nuclear steam cycle is the low thermodynamic condition of the steam. Erosion due to steam condensation is one of the main maintenance issues for the steam turbine. After 10 years of operation, the inspection conducted on the low pressure (LP) modules revealed a satisfactory general condition with some non-uniform erosion on LP diaphragms. The article will highlight the repair solutions and the design evolutions to eliminate such local erosion on the new ARABELLE turbines (i.e. Flamanville 3). As for all the largest turbogenerators, armature windings of N4 generators are cooled by circulation of pure water in copper hollow conductors. The sensibility to copper corrosion of the stator bars hollow conductors has led Alstom to introduce stainless steel cooling tubes in the new products and for rewinding. The next more powerful turbo-machines in the N4 Turbine Island are the main turbine driven feedwater pumps. On the pump side, operating experience including impeller mechanical behaviour, erosion and gear coupling issues will be described with the corrections implemented. (authors)

  3. Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes

    Ksenija Limani

    2014-01-01

    Full Text Available Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU for patients with localized prostate cancer (PCa. Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4% and 50 (46.3% patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year actuarial biochemical recurrence free survival rates were 57% and 40%, respectively. The 10-year overall survival rate, cancer specific survival rate, and metastasis free survival rate were 72%, 90%, and 70%, respectively. Preoperative high risk category, Gleason score, preoperative PSA, and postoperative nadir PSA were independent predictors of oncological failure. 24.5% of patients had self-resolving LUTS, 18.2% had urinary tract infection, and 18.2% had acute urinary retention. A grade 3b complication occurred in 27 patients. Pad-free continence rate was 87.9% and the erectile dysfunction rate was 30.8%. Conclusion. Single session HIFU can be alternative therapy for patients with low risk PCa. Patients with intermediate risk should be informed about the need of multiple sessions of HIFU and/or adjuvant treatments and HIFU performed very poorly in high risk patients.

  4. Reproducibility and Relative Validity of a Short Food Frequency Questionnaire in 9–10 Year-Old Children

    Saeedi, Pouya; Skeaff, Sheila A.; Wong, Jyh Eiin; Skidmore, Paula M. L.

    2016-01-01

    The aim of this study was to assess the reproducibility and validity of a non-quantitative 28-item food frequency questionnaire (FFQ). Children aged 9–10 years (n = 50) from three schools in Dunedin, New Zealand, completed the FFQ twice and a four-day estimated food diary (4DEFD) over a two-week period. Intraclass correlation coefficients (ICC) and Spearman’s correlation coefficients (SCC) were used to determine reproducibility and validity of the FFQ, respectively. Weekly intakes were estimated for each food item and aggregated into 23 food items/groups. More than half of the food items/groups (52.2%) had an ICC ≥0.5. The median SCC between FFQ administrations was 0.66 (ranging from 0.40 for processed meat to 0.82 for sweets and non-dairy drinks). Cross-classification analysis between the first FFQ and 4DEFD for ranking participants into thirds showed that breakfast cereals had the highest agreement (54.0%) and pasta the lowest (34.0%). In validity analyses, 70% of food items/groups had a SCC ≥0.3. Results indicate that the FFQ is a useful tool for ranking children according to food items/groups intake. The low respondent burden and relative simplicity of the FFQ makes it suitable for use in large cohort studies of 9–10 year-old children in New Zealand. PMID:27164137

  5. JSPS-CAS Core University Program seminar on summary of 10-year collaborations in plasma and nuclear fusion research area

    The JSPS-CAS Core University Program (CUP) seminar on “Summary of 10-year Collaborations in Plasma and Nuclear Fusion Research Area” was held from March 9 to March 11, 2011 in the Okinawa Prefectural Art Museum, Naha city, Okinawa, Japan. The collaboration program on plasma and nuclear fusion started from 2001 under the auspices of Japanese Society of Promotion of Science (JSPS) and Chinese Academy of Sciences (CAS). This year is the last year of the CUP. This seminar was organized in the framework of the CUP. In the seminar, 29 oral talks were presented, having 14 Chinese and 30 Japanese participants. These presentations covered key topics related to the collaboration categories: (1) improvement of core plasma properties, (2) basic research on fusion reactor technologies, and (3) theory and numerical simulation. This seminar aims at summarizing the results obtained through the collaborations for 10 years, and discussing future prospects of China-Japan collaboration in plasma and nuclear fusion research areas. (author)

  6. Evaluation of Single-Bundle versus Double-Bundle PCL Reconstructions with More Than 10-Year Follow-Up

    Masataka Deie

    2015-01-01

    Full Text Available Background. Posterior cruciate ligament (PCL injuries are not rare in acute knee injuries, and several recent anatomical studies of the PCL and reconstructive surgical techniques have generated improved patient results. Now, we have evaluated PCL reconstructions performed by either the single-bundle or double-bundle technique in a patient group followed up retrospectively for more than 10 years. Methods. PCL reconstructions were conducted using the single-bundle (27 cases or double-bundle (13 cases method from 1999 to 2002. The mean age at surgery was 34 years in the single-bundle group and 32 years in the double-bundle group. The mean follow-up period was 12.5 years. Patients were evaluated by Lysholm scoring, the gravity sag view, and knee arthrometry. Results. The Lysholm score after surgery was 89.1±5.6 points for the single-bundle group and 91.9±4.5 points for the double-bundle group. There was no significant difference between the methods in the side-to-side differences by gravity sag view or knee arthrometer evaluation, although several cases in both groups showed a side-to-side difference exceeding 5 mm by the latter evaluation method. Conclusions. We found no significant difference between single- and double-bundle PCL reconstructions during more than 10 years of follow-up.

  7. The CERN Accelerator Logging Service- 10 Years in Operation: A Look at the Past, Present and Future

    Roderick, C; Kruk, G

    2014-01-01

    During the 10 years since it's first operational use, the scope and scale of the CERN Accelerator Logging Service (LS) has evolved significantly: from an LHC specific service expected to store 1TB / year; to a CERN-wide service spanning the complete accelerator complex (including related sub-systems and experiments) currently storing more than 50 TB / year on-line for some 1 million signals. Despite the massive increase over initial expectations the LS remains reliable, and highly usable - this can be attested to by the 5 million daily / average number of data extraction requests, from close to 1000 users. Although a highly successful service, demands on the LS are expected to increase significantly as CERN prepares LHC for running at top energy, which is likely to result in at least doubling current data volumes. Furthermore, focus is now shifting firmly towards a need to perform complex analysis on logged data, which in-turn presents new challenges. This paper reflects on 10 years as an operational service,...

  8. A proposed approach in defining population-based rates of major injury from a trauma registry dataset: Delineation of hospital catchment areas (I

    Lyons Ronan A

    2008-04-01

    Full Text Available Abstract Background Determining population-based rates for major injury poses methodological challenges. We used hospital discharge data over a 10-year period (1996–2005 from a national trauma registry, the Trauma Audit and Research Network (TARN Manchester, to construct valid numerators and denominators so that we can calculate population-based rates of major injury in the future. Methods We examined data from all hospitals reporting to TARN for continuity of numerator reporting; rates of completeness for patient postcodes, and clear denominator populations. We defined local market areas (>70% of patients originating from the same postcode district as the hospital. For relevant hospitals we assessed data quality: consistency of reporting, completeness of patient postcodes and for one selected hospital, North Staffordshire Royal Infirmary (NSRI, the capture rate of numerator data reporting. We used an established method based on patient flow to delineate market areas from hospitals discharges. We then assessed the potential competitors, and characterized these denominator areas. Finally we performed a denominator sensitivity analysis using a patient origin matrix based on Hospital Episodes Statistics (HES to validate our approach. Results Sixteen hospitals met the data quality and patient flow criteria for numerator and denominator data, representing 12 hospital catchment areas across England. Data quality issues included fluctuations numbers of reported cases and poor completion of postcodes for some years. We found an overall numerator capture rate of 83.5% for the NSRI. In total we used 40,543 admissions to delineate hospital catchment areas. An average of 3.5 potential hospital competitors and 15.2 postcode districts per area were obtained. The patient origin matrix for NSRI confirmed the accuracy of the denominator/hospital catchment area from the patient flow analysis. Conclusion Large national trauma registries, including TARN, hold

  9. Genital human papillomavirus infection among women in Bangladesh: findings from a population-based survey.

    Quamrun Nahar

    Full Text Available BACKGROUND: There has been no population-based study on human papillomavirus (HPV prevalence or its genotypes in Bangladesh; a country eligible for GAVI funding for HPV vaccine. METHODS: We used baseline survey data of a prospective cohort study that was conducted in one urban and one rural area of Bangladesh. A total of 997 urban and 905 rural married women, aged 13 to 64 years, were enrolled in the baseline during July-December, 2011. Information was collected on socio-demographic characteristics and potential risk factors for HPV infection followed by gynecological examination and collection of endocervical samples using the cervical cytobrush (Digene cervical sampler. HPV DNA testing was done by Polymerase Chain Reaction (PCR using a consensus primer set. RESULTS: Prevalence of any HPV infection was 7.7% with no significant difference between urban and rural women. Most common high-risk genotypes were HPV16, HPV66, HPV18, HPV45, HPV31 and HPV53. Urban women working as housemaids or garment workers were at higher risk of any HPV infection (OR = 2.15, 95% CI: 1.13-4.11 compared to housewives. Rural women whose husband lived overseas were almost two times more likely to have any HPV infection (OR = 1.93; 95% CI 1.05-3.55 compared to women whose husbands lived with them. CONCLUSION: The prevalence of HPV infection among Bangladeshi women is similar to other regions of Asia. However, type-specific patterns are different. The study findings will inform the formulation of HPV vaccination policies in Bangladesh, monitoring the impact of vaccination programmes, and the identification of target populations for screening.

  10. Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study

    Zhou Liya; Lin Sanren; Ding Shigang; Huang Xuebiao; Jin Zhu; Cui Rongli; Meng Lingmei

    2014-01-01

    Background Helicobacter pylori (Hp) is a common and potentially curable cause of gastric mucosa lesion.This study investigated the relationship of Hp infection with histological changes in gastric mucosa and gastric cancer in Hp-positive patients compared with Hp-eradication patients followed up for ten years.Methods From an initial group of 1 006 adults,552 Hp-positive subjects were randomly assigned to a treatment group (T;n=276) or a placebo group (P; n=276).In the randomized,double-blind,placebo-controlled,parallel trial,T group subjects received oral doses of omeprazole,amoxicillin and clarithromycin for 1 week; those in the P group received a placebo.One month after treatment ended,a 13C urea breath test was performed,and Hp was undetectable in 88.89% of the T group.All subjects were followed at 1,5,8,and 10 years after treatment,with endoscopy and biopsies for histological examination.Results Gastric mucosa inflammation was significantly milder in the T group than that in the P group one year after Hp eradication and this persisted for 10 years.Glandular atrophy and intestinal metaplasia (IM) had deteriorated in both groups during ten years.However,the increased score of glandular atrophy at both the gastric antrum and corpus,and IM only at the gastric antrum,in the P group was more obvious than that in the T group.During the 10 years,9 patients were diagnosed with gastric cancer (2 in the T group; 7 in the P group; P=0.176).When mucosal atrophy was absent at the gastric antrum and corpus when entering the study,the incidence of gastric cancer in the P group (n=6) was much higher than that in the T group (n=0,P=0.013).Conclusions Hp eradication may significantly diminish and help halt progression of gastric mucosal inflammation and delay the development of IM and atrophy gastritis.Hp eradication is helpful for reducing the risk for gastric cancer,especially in the early stage of Hp infection.

  11. Who is maintaining weight in a middle-aged population in Sweden? A longitudinal analysis over 10 years

    Wall Stig

    2007-06-01

    Full Text Available Abstract Background Obesity has primarily been addressed with interventions to promote weight loss and these have been largely unsuccessful. Primary prevention of obesity through support of weight maintenance may be a preferable strategy although to date this has not been the main focus of public health interventions. The aim of this study is to characterize who is not gaining weight during a 10 year period in Sweden. Methods Cross-sectional and longitudinal studies were conducted in adults aged 30, 40, 50 and 60 years during the Västerbotten Intervention Programme in Sweden. Height, weight, demographics and selected cardiovascular risk factors were collected on each participant. Prevalences of obesity were calculated for the 40, 50 and 60 year olds from the cross-sectional studies between 1990 and 2004. In the longitudinal study, 10-year non-gain (lost weight or maintained body weight within 3% of baseline weight or weight gain (≥ 3% was calculated for individuals aged 30, 40, or 50 years at baseline. A multivariate logistic regression model was built to predict weight non-gain. Results There were 82,927 adults included in the cross-sectional studies which had an average annual participation rate of 63%. Prevalence of obesity [body mass index (BMI in kg/m2 ≥ 30] increased from 9.4% in 1990 to 17.5% in 2004, and 60 year olds had the highest prevalence of obesity. 14,867 adults with a BMI of 18.5–29.9 at baseline participated in the longitudinal surveys which had a participation rate of 74%. 5242 adults (35.3% were categorized as non-gainers. Older age, being female, classified as overweight by baseline BMI, later survey year, baseline diagnosis of diabetes, and lack of snuff use increased the chances of not gaining weight. Conclusion Educational efforts should be broadened to include those adults who are usually considered to be at low risk for weight gain – younger individuals, those of normal body weight, and those without health

  12. 10-years of Atlantic Overturning observations: variability revealed on sub-annual, seasonal, annual and multi-annual timescales

    McCarthy, Gerard; Johns, William; Meinen, Chris; Baringer, Molly; Rayner, Darren; Moat, Ben; Smeed, David

    2015-04-01

    The RAPID/MOCHA/WBTS project has been measuring the Atlantic Overturning circulation (AMOC) at 26.5 N in the North Atlantic since 2004. The joint UK-US project has recently reached the 10 year milestone. Here we present some of the key results from the first 10 years of the program. The first year's measurements revealed a sub-annual variability that encompassed all previous ship-based, hydrographic estimates of the AMOC, thus showing that a perceived decline could be encompassed in short-term variability. Seasonal variability in the AMOC was larger than expected with a 6 Sv range, with the largest single component derived from wind-stress curl induced density fluctuations at the eastern boundary. Interannual variability, far larger than that present in state of the art climate models, was seen in 2009/10. A 30% reduction lasted 18 months and cooled the subtropical North Atlantic significantly. The existence of continuous heat transport measurements enabled us to show that the main cause of the cooling was a reduction in ocean heat convergence rather than air-sea fluxes. The winter of 2010/11 revealed a second consecutive winter of low AMOC: a double dip. Whether ocean re-emergence or the change in AMOC circulation was the cause of the SST tripole pattern pattern that emerged in the winter of 2010/11 is a topic of ongoing research. Nonetheless, this SST pattern was shown to be sufficient to push the atmosphere into a second consecutive negative wintertime North Atlantic Oscillation (NAO) and increased predictability of this negative NAO. Most recently a multi-year decline in the AMOC has been observed. This 0.5 Sv/year decline is much larger than the long-term decline predicted due to anthropogenic climate change. The decline first reported on the 8.5-year timeseries has continued in the 10-year timeseries. The magnitude of the decline is so large as to suggest it may be decadal variability. A decline in the AMOC is consistent with a declining phase of the Atlantic

  13. Monitoring the Affordability of Healthy Eating: A Case Study of 10 Years of the Illawarra Healthy Food Basket

    Peter Williams

    2010-11-01

    Full Text Available Healthy food baskets have been used around the world for a variety of purposes, including: examining the difference in cost between healthy and unhealthy food; mapping the availability of healthy foods in different locations; calculating the minimum cost of an adequate diet for social policy planning; developing educational material on low cost eating and examining trends on food costs over time. In Australia, the Illawarra Healthy Food Basket was developed in 2000 to monitor trends in the affordability of healthy food compared to average weekly wages and social welfare benefits for the unemployed. It consists of 57 items selected to meet the nutritional requirements of a reference family of five. Bi-annual costing from 2000–2009 has shown that the basket costs have increased by 38.4% in the 10-year period, but that affordability has remained relatively constant at around 30% of average household incomes.

  14. More than 10 years survival with sequential therapy in a patient with advanced renal cell carcinoma: a case report

    Although radical nephrectomy alone is widely accepted as the standard of care in localized treatment for renal cell carcinoma (RCC), it is not sufficient for the treatment of metastatic RCC (mRCC), which invariably leads to an unfavorable outcome despite the use of multiple therapies. Currently, sequential targeted agents are recommended for the management of mRCC, but the optimal drug sequence is still debated. This case was a 57-year-old man with clear-cell mRCC who received multiple therapies following his first operation in 2003 and has survived for over 10 years with a satisfactory quality of life. The treatments given included several surgeries, immunotherapy, and sequentially administered sorafenib, sunitinib, and everolimus regimens. In the course of mRCC treatment, well-planned surgeries, effective sequential targeted therapies and close follow-up are all of great importance for optimal management and a satisfactory outcome

  15. Looking back on 10 years of the ATLAS Metadata Interface. Reflections on architecture, code design and development methods

    The 'ATLAS Metadata Interface' framework (AMI) has been developed in the context of ATLAS, one of the largest scientific collaborations. AMI can be considered to be a mature application, since its basic architecture has been maintained for over 10 years. In this paper we describe briefly the architecture and the main uses of the framework within the experiment (TagCollector for release management and Dataset Discovery). These two applications, which share almost 2000 registered users, are superficially quite different, however much of the code is shared and they have been developed and maintained over a decade almost completely by the same team of 3 people. We discuss how the architectural principles established at the beginning of the project have allowed us to continue both to integrate the new technologies and to respond to the new metadata use cases which inevitably appear over such a time period.

  16. Dental health behaviors and periodontal disease indicators in Danish youths. A 10-year epidemiological follow-up

    Lissau, I; Holst, D; Friis-Hasché, E

    1990-01-01

    pockets (0-3 mm), shallow pockets (4-5 mm), and deep pockets (6+ mm). The indicators were measured on 4 surfaces on 6 index teeth (16, 11, 26, 36, 31, 46) in 1984-85. The highest value for each tooth of bleeding (0/1), calculus (0/1) and pockets (0/1/2) was used for calculation of the bleeding index, the...... calculus index and the pocket index. The participation rate in 1984-85 was 86%, and the study population involved 368 males and 388 females. Information concerning dental health behavior was obtained both in childhood (1974) when the individuals were 9-10 years of age, and in adulthood (1984-85) when the......The purpose of the present study was to analyse the epidemiologic relationship between dental health behaviors and periodontal disease. Indicators of periodontal disease in terms of bleeding and calculus were measured dichotomously (absence/presence). Periodontal pockets were as follows: normal...

  17. Self-assessed job satisfaction and ischaemic heart disease mortality: a 10-year follow-up of urban bus drivers

    Netterstrøm, B; Suadicani, P

    1993-01-01

    Several studies have shown that bus driving is a high-risk occupation for ischaemic heart disease (IHD). In order to study contributing factors in the job, all male full-time bus drivers in the three major cities in Denmark were followed for 10 years. It was hypothesized that bus drivers who...... reported job strain and job dissatisfaction would have an excess risk of subsequent death due to IHD. Of 2465 bus drivers, 2045 (83%) responded to a questionnaire distributed in 1978 on psychosocial well-being and work conditions. The men had their mortality recorded during the years 1978-1988. Information...... on causes of death was obtained from the Danish Register of Causes of Death. Some 212 respondents died during the follow-up period, 59 from IHD. Relative risk (RR) for death due to IHD and all other causes of death was calculated. As expected, we found a significantly increased risk of IHD in bus...

  18. Liver transplantation for chronic graft-versus-host disease: case report with 10-year follow-up.

    Orlando, Giuseppe; Ferrant, Augustin; Schots, Rik; Goffette, Pierre; Mathijs, Jules; Lemaire, Julien; Danse, Etienne; Talpe, Stéphanie; Latinne, Dominique; Lerut, Jan

    2005-01-01

    Graft-versus-host disease (GVHD) is a frequent complication of bone marrow transplantation (BMT). Chronic GVHD (cGVHD) may lead to irreversible liver failure. We report a case of successful liver transplantation (LT) for end-stage liver failure because of cGVHD that had developed 22 months after BMT in a 24-year-old male. Re-transplantation was necessary 6 months later because of intrahepatic ischaemic type biliary tract lesions. He is now in excellent condition 10 years after the first transplant. This experience and the review of literature indicate that LT can cure GVHD-related chronic liver failure. Recurrent GVHD in the allograft has not yet been reported. PMID:15612994

  19. Two-Stage Procedure for Infected Aortic Graft Pseudoaneurysm: 10-Year Follow Up after Omental Prosthesis Wrapping.

    von Aspern, Konstantin; Etz, Christian D; Mohr, Friedrich W; Battellini, Roberto R

    2015-08-01

    Prosthetic graft infections with mediastinitis following aortic surgery are rare, yet represent grave complications yielding high morbidity and mortality. We present the case of a 57-year-old female patient with past history of emergent surgery for iatrogenic Type A dissection treated by supracoronary ascending aortic replacement. Four months after the initial surgery, a sternal fistula had formed and due to severe bleeding emergent reoperation was required. Imaging and pathology on admission revealed an infected pseudoaneurysm at the distal aortic prosthesis and mediastinitis with methicillin-resistant Staphylococcus aureus. Rescue surgery was performed by means of a two-stage approach, with extensive debridement, graft replacement and continuous antiseptic lavage in a first step and an omental wrapping of the new prosthesis in a second stage 24 hours later. During 10 years of follow-up, no recurrent infection occurred. The operative approach and general considerations for management of infected pseudoaneurysms are discussed. PMID:27069945

  20. More than 10 years survival with sequential therapy in a patient with advanced renal cell carcinoma: a case report

    Yuan, J.L.; Wang, F.L.; Yi, X.M.; Qin, W.J.; Wu, G.J. [Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi' an, Shaanxi (China); Huan, Y. [Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi' an, Shaanxi (China); Yang, L.J.; Zhang, G.; Yu, L.; Zhang, Y.T.; Qin, R.L.; Tian, C.J. [Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi' an, Shaanxi (China)

    2014-10-31

    Although radical nephrectomy alone is widely accepted as the standard of care in localized treatment for renal cell carcinoma (RCC), it is not sufficient for the treatment of metastatic RCC (mRCC), which invariably leads to an unfavorable outcome despite the use of multiple therapies. Currently, sequential targeted agents are recommended for the management of mRCC, but the optimal drug sequence is still debated. This case was a 57-year-old man with clear-cell mRCC who received multiple therapies following his first operation in 2003 and has survived for over 10 years with a satisfactory quality of life. The treatments given included several surgeries, immunotherapy, and sequentially administered sorafenib, sunitinib, and everolimus regimens. In the course of mRCC treatment, well-planned surgeries, effective sequential targeted therapies and close follow-up are all of great importance for optimal management and a satisfactory outcome.