UK PubMed Central (United Kingdom)

SummaryBackgroundPatients undergoing dialysis have a substantially increased risk of cardiovascular mortality and morbidity. Although several trials have shown the...Full Text Available

UK PubMed Central (United Kingdom)

Antiplatelet resistance has been proposed as a possible mechanism to explain recurrent cardiovascular events in patients who have coronary artery disease and who are undergoing dual antiplatelet therapy....Full Text Available

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PMID:3716246

KoreaScience (Korea)

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Context. Cardiovascular medication overdoses can be difficult to treat. Various treatment modalities are currently recommended. Objective. To describe patient outcomes and adverse events of high-dose insulin therapy in consecutive overdose patients in cardiogenic shock after implementation of a high-dose insulin protocol (1-10 U/kg/h, while avoiding or tapering off vasopressors). Methods. This is an observational consecutive case series of patients identified from a registry. Data were collected by retrospective chart review of patients treated by our toxicology service with this protocol from February 2007 until March 2010. Results. Twelve patients were treated with high-dose insulin. The mean age was 36.5 years (SD 11.7). Seven patients had pre-existing vasopressor therapy, and all were ...

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Background. The `RISchio CArdiovascolare nei pazienti afferenti all' Area Vasta In Dialisi (RISCAVID) study is an observational and prospective trial including the whole chronic haemodialysis (HD) population in the northwest part of Tuscany (1.235 million people). The aim of the study was to elucidate the relevance of traditional and non-traditional risk factors of mortality and morbidity in HD patients as well as the impact of different HD modalities.Methods. A total of 757 HD patients (mean age 66 +- 14 years, mean dialytic age 70 +- 76 months, diabetes 19%) were prospectively followed up for 30 months and all-cause mortality, cardiovascular (CV) mortality and non-fatal CV events (acute myocardial infarction and stroke) were registered. At the time of the enrolment, demographic, clinical...

DEFF Research Database (Denmark)

Udgivelsesdato: 2007/6

UK PubMed Central (United Kingdom)

BackgroundMore optimistic perceptions of cardiovascular disease risk are associated with substantively lower rates of cardiovascular death among men. It remains unknown whether this...Full Text Available

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Cardiac Arrest; Coronary Disease; Cardiovascular Risk Factors

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Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundHealthcare professionals can play a crucial role in optimizing the health status of patients with cardiovascular risk factors (abdominal obesity, high blood pressure, low...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundExcessive television (TV) viewing might play an important role in the development of cardiovascular disease (CVD). The aim of this study was to examine the independent...Full Text Available

UK PubMed Central (United Kingdom)

Characteristics relevant to cardiovascular disease, including anthropometry, arterial blood pressure, serum cholesterol levels, chest radiography and electrocardiography, were investigated in a survey...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIn 1988, the SPILI project was established in order to evaluate the cardiovascular disease (CVD) risk profile of the inhabitants of Spili, in rural Crete, Greece. The first...Full Text Available

UK PubMed Central (United Kingdom)

Advanced glycation end products (AGEs) have been reported to contribute to aging and cardiovascular complications. In the present study, the immunoreactivity of AGEs in human serum samples of healthy...Full Text Available

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Healthy Volunteers; Markers of Cardiovascular Risk

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The effects of 0.2 and 0.5 mL/kg Innovar (a neuroleptic analgesic) on cardiovascular functions and reflexes in rabbits were measured. We recorded the effects of Innovar on arterial pressure, heart rate, respiration rate, ventricular contractility, arterial oxygen tension, as well as the drug's effects on the bradycardia and vasoconstrictor response to cigarette smoke stimulation of the nose (the so-called "nasopharyngeal reflex"). In animals given 0.2 mL/kg Innovar, all steady state cardiovascular variables had returned to pre-Innovar levels in 45 min, as had the efficacy of the nasopharyngeal reflex. In animals given 0.5 mL/kg Innovar, all steady state cardiovascular variables, except PaO2, were slightly but significantly depressed for up to 135 min after injection. The nasopharyngeal reflex returned to normal within 90 min. Because of the calmative and analgesic effects of Innovar, and its only moderate effects on ...

UK PubMed Central (United Kingdom)

BackgroundIncrease in the incidence of hyperuricemia associated with gout as well as hypertension, renal diseases and cardiovascular diseases has been a public health concern. We...Full Text Available

UK PubMed Central (United Kingdom)

INTRODUCTION:Postprandial lipemia is characterized by an increased concentration of circulating lipids after fat intake and is an independent risk factor for cardiovascular disease....Full Text Available

UK PubMed Central (United Kingdom)

Hyperglycemia frequently occurs with acute medical illness, especially among patients with cardiovascular disease, and has been linked to increased morbidity and mortality in critically ill patients....Full Text Available

UK PubMed Central (United Kingdom)

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

UK PubMed Central (United Kingdom)

Nowadays it is accepted that natural flavonoids present in fruits and plant-derived-foods are relevant, not only for technological reasons and organoleptic properties, but also because of their potential...Full Text Available

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BackgroundCardiovascular magnetic resonance (CMR) allows volumetric carotid plaque measurement that has advantage over 2-dimensional ultrasound (US) intima-media thickness (IMT)...Full Text Available

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Three analogs of lidocaine (benzyl carbamyl, benzyl nitrile and methyl nitrile) were synthesized and examined for cardiovascular and central activity. The benzyl carbamyl analog was more potent than lidocaine in lowering blood pressure but possessed only slight local anesthetic, antiarrhythmic and CNS-depressant activity. At 40 mg/kg the benzyl nitrile derivative was superior to lidocaine in protecting against chloroform-induced arrhythmias. The methyl nitrile analog was less active than the benzyl nitrile analog in most parameters examined. The benzyl nitrile derivative and lidocaine had similar potencies on blood pressure depression, local anesthetic activity and ability to protect against calcium chloride-induced arrhythmias. Unlike the benzyl carbamyl derivative both lidocaine and the benzyl nitrile compounds appear to depress the cardiovascular system via a common mechanism. PMID:515167

UK PubMed Central (United Kingdom)

A consecutive series of 101 pituitary tumours treated in the 10 year period 1968-78 has been examined, giant lesions being excluded. There were 48 female cases and 53 male, women predominating in the...Full Text Available

UK PubMed Central (United Kingdom)

Over the past 10 years, the Peruvian National Tuberculosis (TB) Program, the National Reference Laboratory (NRL), Socios en Salud, and US partners have worked to strengthen the national TB laboratory...Full Text Available

UK PubMed Central (United Kingdom)

Over the past 10 years, the original partnership of clinician and statistician for the running of clinical research projects, especially clinical trials, has come to be supplemented by the data manager...Full Text Available

UK PubMed Central (United Kingdom)

This study explored posttraumatic growth (PTG), positive change resulting from struggling with trauma, among 7- to 10-year-olds impacted by Hurricane Katrina. Analyses focused on child self-system...Full Text Available

UK PubMed Central (United Kingdom)

The earliest clinical evidence of diabetic nephropathy is microalbuminuria. Progression from microalbuminuria to overt nephropathy occurs in 20-40% within a 10-year period with approximately 20% of...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAntioxidant vitamins are often described as having “independent” associations with risk of cancer, cardiovascular disease (CVD) and mortality. We aimed...Full Text Available

UK PubMed Central (United Kingdom)

Five standard, non-invasive tests of cardiovascular, autonomic function were performed in each of four groups of 30 subjects: controls, group 1, diabetics without clinical evidence of neuropathy; group...Full Text Available

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AbstractBackgroundGender concordance between patients and their physicians is related to prevention screening and other quality indicators. Research suggests female...Full Text Available

UK PubMed Central (United Kingdom)

The noninvasive assessment of cardiac function is of first importance for the diagnosis of cardiovascular diseases. Among all medical scanners only a few enables radiologists to evaluate the local cardiac...Full Text Available

UK PubMed Central (United Kingdom)

Background. Detection of subjects with early chronic kidney disease (CKD) is important because some will progress up to stage 5 CKD, and most are at high risk of cardiovascular morbidity...Full Text Available

UK PubMed Central (United Kingdom)

Cardiovascular modelling has been a major research subject for the last decades. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of...Full Text Available

UK PubMed Central (United Kingdom)

BACKGROUND: Each component of metabolic syndrome (MS) conveys increased cardiovascular disease risk, but as a combination they become much more powerful. Vigorous early management of the syndrome may...Full Text Available

Medline Plus

... different personal wellness goals for you. HIV Health Management With a good medical team and a desire to reach wellness goals , people with HIV can have a virtually normal lifespan. Take the HIV Wellness Quiz Test your knowledge and find out where you need to learn ...

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This book provides differential diagnostic possibilities of specific scan abnormalities in one volume for easy reference. This book is organized by organ systems and covers the central nervous system, the endocrine, skeletal, pulmonary, gastrointestinal, genitourinary, and cardiovascular systems. The gamuts are designed to teach differential diagnosis and to assist in the actual interpretation of patient slides.

UK PubMed Central (United Kingdom)

OBJECTIVE: The risk of cardiovascular and renal diseases has been shown to be higher for systolic blood pressure than diastolic blood pressure. The aim of this study was to assess the differential control...Full Text Available

UK PubMed Central (United Kingdom)

Catheter ablation is a first line treatment for many cardiac arrhythmias and is generally performed under x-ray fluoroscopy guidance. However, current techniques for ablating complex arrhythmias such...Full Text Available

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The major emphasis of this past year's research effort toward characterizing the responses of the cardiovascular system of the military working dog has been to obtain renal hemodynamic information from dogs involved in various stages of obedience, scoutin...

UK PubMed Central (United Kingdom)

Objective: Determine and compare the prevalence of known risk factors for cardiovascular disease among unselected individuals presenting with their first ever episode of...Full Text Available

UK PubMed Central (United Kingdom)

AMP-activated protein kinase (AMPK) was initially viewed as energy sensor and activated by increased intracellular concentrations of AMP following nutrient deprivation. Physiological or pathological...Full Text Available

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Menopause is characterized by the progressive reduction of estrogens resulting to cessation of menses. It is associated with an increase of cardiovascular risk factors such as hyperglycemia, hypertension, dyslipidemia and of abdominal and/or selective visceral fat mass deposition. Obesity, a modern day epidemic, is promoted by an obesogenic environment that interacts with the genetic background. The result is a positive energy balance materialized by the accumulation of the adipose tissue. This process is marked by great individual variation. Obesity is also associated with the presence of cardiovascular risk factors. In this review, the main pathophysiologic processes for the increase of obesity in menopause and the possible effects of pre-menopausal obesity regarding the cessation of ova...

International Nuclear Information System (INIS)

Continuum events represent an eminent source of background in any e+e- experiment. As these have a higher branching ratio than BB-bar events (at BaBar this ratio is estimated to about 3.5) or ?+?- events, efficient continuum background suppression is essential in many analyses. Using Artificial Neural Networks and the Nearest Neighbor Method we developed several selectors which, based only on the global event shape variables, efficiently tag BB-bar events and ?+?- events against the continuum background. These selectors could then be combined with the channel specific information in various types of analyses. The study was done using a parametric Monte Carlo.

CERN Multimedia

CMS collision events: first 900GeV collisions, 23rd Nov 2009

British Library Electronic Table of Contents (United Kingdom)

Aims We tested cardiovascular and visceromotor reflex (VMR) responses to urinary bladder distension (UBD) in urethane anesthetized rats to see if it can replicate the response pattern and the inhibition of bladder nociceptive transmission by analgesics seen in isoflurane anesthetized animals. Methods Female Sprague-Dawley rats under 3% isoflurane anesthesia were acutely instrumented with jugular venous, carotid arterial, and bladder cannulas for drug administration, blood pressure (BP) measurement, and bladder distension, respectively. Needle electrodes were placed directly into the abdominal musculature to measure myoelectrical activity subsequent to phasic UBD (30 sec in 3 min intervals). A cardiovascular response (pressor) and a VMR response (a contraction of abdominal and hind limb mus...

British Library Electronic Table of Contents (United Kingdom)

Aims.- To examine the relationships between depression, coronary artery disease, type 2 diabetes, metabolic syndrome and quality of life in Taiwanese adults from a cardiovascular department of a major hospital in Taiwan. Background.- Research suggests associations between depression, metabolic syndrome and quality of life. Despite this fact, few studies have investigated these relationships among Taiwanese. Design.- A cross-sectional descriptive correlational design was used to conduct this study. Methods.- A convenience sample of 140 adults participated in the study. Data were analysed with descriptive statistics, Pearson-s correlations, hierarchical regression and t-tests. Results.- Almost a half of the subjects (465%) had metabolic syndrome. The most common combination of metabolic synd...

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This report discusses whether the events that occur in the universe evolve deterministicly or randomly or both. (LSP).

UK PubMed Central (United Kingdom)

A total of 213 treated and 16 control monkeys comprising 12 experimental groups was evaluated for determination of the long-term (10 years) effects of various dosages of a variety of synthetic oral...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundUsing a transcriptional profiling approach, we recently identified myeloid-related protein-8/14 (MRP-8/14) to be expressed by platelets during acute MI....Full Text Available

UK PubMed Central (United Kingdom)

Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we...Full Text Available

UK PubMed Central (United Kingdom)

Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR)...Full Text Available

International Nuclear Information System (INIS)

Daya Bay Nuclear Power Plant is put into commercial operation in 1994 Until 1996, there are 368 human error events in operating and maintenance area, occupying 39% of total events. These events occurred mainly in the processes of maintenance, test equipment isolation and system on-line, in particular in refuelling and maintenance. The author analyses root causes for human errorievents, which are mainly operator omission or error procedure deficiency; procedure not followed; lack of training; communication failures; work management inadequacy. The protective measures and treatment principle for human error events are also discussed, and several examples applying them are given. Finally, it is put forward that key to prevent human error event lies in the coordination and management, person in charge of work, and good work habits of staffs.

Science.gov (United States)

Analysts working at the International Data Centre in support of treaty monitoring through the Comprehensive Nuclear-Test-Ban Treaty Organization spend a significant amount of time reviewing hypothesized seismic events produced by an automatic processing system. When reviewing these events to determine their legitimacy, analysts take a variety of approaches that rely heavily on training and past experience. One method used by analysts to gauge the validity of an event involves examining the set of stations involved in the detection of an event. In particular, leveraging past experience, an analyst can say that an event located in a certain part of the world is expected to be detected by Stations A, B, and C. Implicit in this statement is that such an event would usually not be detected by Stations X, Y, or Z. For some well understood parts of the world, the ...

UK PubMed Central (United Kingdom)

The sequential events and the inflammatory mediators that characterize disease onset and progression of ulcerative colitis (UC) are not well known. In this study, we evaluated the early pathologic events...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSubtle alternative splicing events involving tandem splice sites separated by a short (2-12 nucleotides) distance are frequent and evolutionarily widespread in eukaryotes,...Full Text Available

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Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction of adverse events at much earlier...Full Text Available

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PMID:11835026

Energy Technology Data Exchange (ETDEWEB)

The paper presents a review of the current state of knowledge on the likely impacts of extreme weather and climate events on coastal zones and small islands in the context of climate change. Possible response options, including prevention, preparedness and adaptation, are indicated.

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The probabilistic external events analysis performed for the Savannah River Site K-reactor PRA considered many different events which are generally perceived to be external'' to the reactor and its systems, such as fires, floods, seismic events, and transportation accidents (as well as many others). Events which have been shown to be significant contributors to risk include seismic events, tornados, a crane failure scenario, fires and dam failures. The total contribution to the core melt frequency from external initiators has been found to be 2.2 {times} 10{sup {minus}4} per year, from which seismic events are the major contributor (1.2 {times} 10{sup {minus}4} per year). Fire initiated events contribute 1.4 {times} 10{sup {minus}7} per year, tornados 5.8 {times} 10{sup {minus}7} per year, dam failures 1.5 {times} 10{sup ...

UK PubMed Central (United Kingdom)

BackgroundOur motor actions normally generate sensory events, but how do we know which events were self generated and which have external causes? Here we use temporal adaptation...Full Text Available

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Initial results obtained with a Monte Carlo computer program designed to link initial physical events in irradiated liquid water with subsequent chemical and biological events are presented. 10 refs., 4 figs., 3 tabs.

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Stroke; Transient Ischemic Attack

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Event-based biosurveillance is a scientific discipline in which diverse sources of data, many of which are available from the Internet, are characterized prospectively to provide information on infectious disease events. Biosurveillance complements traditional public health surveillance to provide both early warning of infectious disease events and situational awareness. The Global Health Security Action Group of the Global Health Security Initiative is developing a biosurveillance capability that integrates and leverages component systems from member nations. This work discusses these biosurveillance systems and identifies needed future studies.

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No abstract available.

International Nuclear Information System (INIS)

With the practice of 10 years safe operation, Daya Bay Nuclear Power Station has established and continuously improved the management system for radiation protection and optimization (ALARA) which contains 3 basic requirements: all workers are trained, all employees are engaged in totally, and work management is implemented for the whole process. At the same time, strong efforts have been made to build the 'infrastructure' as a platform for its effective operation. This article introduces the contents and characteristics of the system and basic experiences of its effective implementation. In order to implement the management system effectively, it is necessary for NPPs to strengthen the responsibility system for radiation protection and the leading role of the radiation protection personnel, especially the role of technical support and supervision during the work with high radiation risk, emphasize the organic combination and actively mutual ...

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Abstract Objective: This study aims to gain an overview of hot topics related to research focused on Chinese herbal drugs by authors inside China and outside of China in the past 10 years. Methods: PubMed/MEDLINE was utilized in order to investigate and select research that was published on ?Chinese herbal drugs?? from 1998 to 2007, by authors located both inside and outside of China (MeSH terms were downloaded and ranked). MeSH terms that frequently appeared were identified and co-word analysis was carried out for two groups: (1) authors located in China, and (2) authors based outside of China, respectively. The hot topics concerning research into Chinese herbal drugs were concluded after cluster analysis and related document analysis. Results: For authors in the China group versus those ...

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For over 50 years, the Bonneville Power Administration (BPA) has evolved to supply electric power to more than 170 customer utilities and direct service industries across 14,800 miles of high voltage transmission lines. BPA`s Office of Engineering provides the planning, development, and engineering for the required expansion, upgrade, and replacement of the transmission system. The purpose of this 10-Year Plan is to present strategies to maintain a reliable energy delivery system within changing public, business, technological, and environmental climates. The issues and trends discussed in this document and our strategies for addressing them provide the background for the Office of Engineering programs and projects. With a budget in the hundreds of millions annually and increasing public concern, we welcome the opportunity to communicate with our customers. In addition to the factors, trends and issues described in this document are two ...

International Nuclear Information System (INIS)

The authors describe the various human error encountered during Daya bay refueling overhaul, and the subsequent root cause evaluation and protective measure. Authors consider transparency is the key in reducing human error and event recurrence. Additional y, event transparency will enhance the effectiveness if experience feedback and reduce event consequence

International Nuclear Information System (INIS)

Within about 10 years, microelectronic devices will be made with more than a billion (10"9) electronic components per chip. To implement such a sophisticated technology it will be essential to have a fundamental understanding of the solid state interaction between the different materials in thin film semiconductor structures. This is the main purpose of this research program. Characterization and analysis is carried out mainly by Rutherford backscattering spectrometry and channelling using accelerated nuclear particles from the Van de Graaff accelerator, while radioactive isotopes provide information about interaction mechanisms. 6 figs., 1 ref.

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Geothermal heat pump systems are a promising new energy technology that has shown rapid increase in usage over the past 10 years in the United States. These systems offer substantial benefits to consumers and utilities in energy (kWh) and demand (kW) savings. The purpose of this study was to determine what existing monitored data were available mainly from electric utilities on heat pump performance, energy savings, and demand reduction for residential, school, and commercial building applications. Information was developed on the status of electric utility marketing programs, barriers to market entry, incentive programs, and benefits.

International Nuclear Information System (INIS)

Purpose: To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. Patients and Methods: Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins. Results: Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients #<=# 14 years at diagnosis had overall survival rates of 66% and 61% at 5 and 10 years compared to older patients with corresponding ...

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Abstract Anesthetics affect outcomes from central nervous system (CNS) injuries differently. This is the first study to show how two commonly used anesthetics affect continuously recorded hemodynamic parameters and locomotor recovery during a 2-week period after two levels of contusion spinal cord injury (SCI) in rats. We hypothesized that the level of cardiovascular depression and recovery of locomotor function would be dependent upon the anesthetic used during SCI. Thirty-two adult female rats were subjected to a sham, 25-mm or 50-mm SCI at T3-4 under pentobarbital or isoflurane anesthesia. Mean arterial pressure (MAP) and heart rate (HR) were telemetrically recorded before, during, and after SCI. Locomotor function recovered best in the 25-mm-injured isoflurane-anesthetized animals. There was no significant difference in locomotor recovery between the 25-mm-injured pentobarbital-anesthetized animals and the 50-mm-injured isoflurane-anesthetized animals. White ...

International Nuclear Information System (INIS)

The placental transfer of a single intravenous injection of 14C-hexoprenaline was studied in eight pregnant New Zealand white rabbits. Maternal and fetal blood was sampled intermittently for 60 minutes after the injection. An initial rapid decrease in the levels of 14C-hexoprenaline in maternal blood was followed by a second slower phase, whereas fetal levels remained insignificant. The conclusion, therefore, is that the rapid improvement in fetal heart rate after the administration of a single maternal intravenous injection of hexoprenaline in the treatment of fetal distress is due to the action on the uterus and/or on maternal cardiovascular function, and not to direct stimulation of the fetus.

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Abstract This article summarizes the results of a Nutrient Biomarker Study in the Women's Health Initiative, and its application to studies of the association between energy and protein consumption and the risk of major cancers and cardiovascular diseases. The presentation emphasizes measurement error modeling and related data analysis methods, since addressing measurement issues appears to be central to these topics and to progress in nutritional epidemiology more generally. The manner in which body mass index is modeled in disease association analysis is particularly challenging, since it could serve as a mediator or as a confounder of the association, and at the same time contributes valuably to energy and protein consumption assessment. A hazard ratio parameter estimation procedure tha...

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Regular physical activity (PA) decreases the risk of several chronic diseases including some cancers, type II diabetes, obesity, and cardiovascular disease; however, the majority of US adults are not meeting the recommended levels to experience these benefits. To address this public health concern, the underlying mechanisms for behavior change need to be understood, translated and disseminated into appropriately tailored interventions. The Transtheoretical Model (TTM) provides a framework for both the conceptualization and the measurement of behavior change, as well as facilitating promotion strategies that are individualized and easily adapted. The purpose of this manuscript is to present the constructs of the TTM as they relate to PA behavior change. We begin with a brief synopsis of rec...

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Summary Analyses of event runoff coefficients provide essential insight on catchment response, particularly if a range of catchments and a range of events are compared by a single indicator. In this study we examine the effect of climate, geology, land use, flood types and initial soil moisture conditions on the distribution functions of the event runoff coefficients for a set of 14 mountainous catchments located in the eastern Italian Alps, ranging in size from 7.3 to 608.4km2. Runoff coefficients were computed from hourly precipitation, runoff data and estimates of snowmelt. A total of 535 events were analysed over the period 1989-2004. We classified each basin using a "permeability index" which was inferred from a geologic map and ranged from "low" to "high permeability". A continuous s...

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This project investigated new techniques for improving seismic event locations derived from regional and local networks. The technqiues include a new approach to empirical travel-time calibration that simultaneously fits data from multiple stations and events, using a generalization of the kriging method, and predicts travel-time corrections for arbitrary event-station paths. We combined this calibration approach with grid-search event location to produce a prototype new multiple-event location method that allows the use of spatially well-distributed events and takes into account correlations between the travel-time corrections from proximate event-station paths. Preliminary tests with a high quality data set from Nevada Test Site explosions indicated that our new calibration/location method offers improvement over the conventional ...

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ArgoNeuT, a Liquid Argon Time Projection Chamber (LAr-TPC), has recently collected thousands of neutrino and anti-neutrino events between 0.1 and 10 GeV in the NuMI beamline at Fermilab (FNAL). Among other issues, the experiment will measure the cross section of the neutrino and anti-neutrino Charged Current Quasi-Elastic (CCQE) interaction on Ar target and analyze the vertex activity associated with such events. Outcomes from the reconstruction of the events provide the main subject of this paper.

International Nuclear Information System (INIS)

A LiF crystal analyzer has been used to measure phonon creation events when a low energy He beam scatters from a Cu(001) surface at low temperature (16 "0K). As only phonon creation events were observed, the inelastic scattering was subspecular. Atom parallel momentum gain and loss events were observed and both bulk and surface modes contributed to the inelastic scattering. An elastic component of scattering was observed over a wide angular range.

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I'e:aEre looking for'events that meet'the following criteria;. Sponsored bv a reputable'organization"-that-is,' willing to provide basic de_tails ...

UK PubMed Central (United Kingdom)

BackgroundThe evolution of eukaryotic cells is widely agreed to have proceeded through a series of endosymbiotic events between larger cells and proteobacteria or cyanobacteria,...Full Text Available

UK PubMed Central (United Kingdom)

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

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We examine the short-term price behaviour of three, size-conditioned Indian stock market indices, in response to informational shocks. A standard mean-adjusted returns model as well as the GJR-GARCH specification point towards underreaction to negative events in the medium and small capitalization indices. Also, the pre-event coefficients are generally negative and statistically significant, regardless of the sign of the shock, thus ruling out information leaks. We uncover a stable abnormal volatility pattern which increases monotonically a few days before the shock before suddenly decreasing in magnitude on the event day and beyond. We suggest uncertainty avoidance as a potential explanation of these features. The results are fairly robust across alternative event selection procedures, ti...

UK PubMed Central (United Kingdom)

BackgroundAlternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human...Full Text Available

CERN Document Server

We have searched for neutron-antineutron oscillations using the 5.56 fiducial kiloton-year exposure of the Soudan 2 iron tracking calorimeter. We require candidate n-nbar occurrences to have .GE. 4 prongs (tracks and showers) and to have kinematics compatible with nbar-N annihilation within a nucleus. We observe five candidate events, with an estimated background from atmospheric neutrino and cosmic ray induced events of 4.5 \\pm 1.2 events. Previous experiments with smaller exposures observed no candidates, with estimated background rates similar to this experiment. We set a lifetime lower limit for oscillation time in iron: T_A(Fe) > 7.2x10^{31} years. The corresponding lower limit for oscillation of free neutrons is \\tau_{n-nbar} > 1.3x10^8 seconds.

CERN Document Server

RFID technology is gaining adoption on an increasing scale for tracking and monitoring purposes. Wide deployments of RFID devices will soon generate an unprecedented volume of data. Emerging applications require the RFID data to be filtered and correlated for complex pattern detection and transformed to events that provide meaningful, actionable information to end applications. In this work, we design and develop SASE, a com-plex event processing system that performs such data-information transformation over real-time streams. We design a complex event language for specifying application logic for such transformation, devise new query processing techniques to effi-ciently implement the language, and develop a comprehensive system that collects, cleans, and processes RFID data for deliv-ery of relevant, timely information as well as storing necessary data for future querying. We demonstrate an initial prototype of SASE ...

Science.gov (United States)

A position-sensitive event-counting electronic readout system for microchannel plates (MCPs) is described that offers the advantages of high spatial resolution and fast time resolution. The technique relies upon a four-quadrant electron-collecting anode located behind the output face of the microchannel plate, so that the electron cloud from each detected event is partly intercepted by each of the four quadrants. The relative amounts of charge collected by each quadrant depend on event position, permitting each event to be localized with two ratio circuits. A prototype quadrant anode system for ion, electron, and extreme ultraviolet imaging is described. The spatial resolution achieved, approx. =10 ..mu.., allows individual MCP channels to be distinguished. (AIP)

International Nuclear Information System (INIS)

The moderate earthquake of magnitude 5.2 was occurred at the offshore Uljin on the 29 May 2004. The magnitude of the event is the largest one which is equal to that of the Sokrisan earthquake on the 16 September 1978 since the beginning of the instrumental recording by the Korean Metrological Administration (KMA) in 1978. The magnitude of the event was large enough to be felt in a wide area of the southern Korea. It did not affect the safety of the Uljin nuclear power plant (NPP) site which is about 80 km away from the epicenter. In this article, we estimate source parameters of the event and evaluate preliminary seismic safety of the Uljin NPP site regarding the event as an empirical Green's function (EGF)

International Nuclear Information System (INIS)

Level 1 and 2 probabilistic safety assessments (PSAs) for both internal and external events are being performed to meet one of the conditions for a construction permit for Wolsong units 2, 3, and 4 in Korea. These units are CANDU-6 Pressurized Heavy Water Reactors (PHWRs), and the study is the first comprehensive level 1 and 2 PSAs for CANDU type plants in the world. The detailed PSA includes and extensive fault tree, event tree analysis, human reliability analysis, and common cause failure analysis. Event trees have been developed for 35 internal initiating event groups. The preliminary results show that the total core damage frequency for Wolsong units 2, 3, and 4 each is similar to that for a typical PWR plant. (author).

UK PubMed Central (United Kingdom)

AIMSTo develop a population pharmacokinetic–pharmacodynamic model to describe the occurrence and severity of bleeding or bruising as a function of enoxaparin exposure.METHODSData...Full Text Available

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Nov 12, 2010 ... The adaptive, nonparametric matched filter algorithm suggested by Kay ... For the point design of a 4 sigma single event SNR the combined NR ...

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UUV coordination. Event Estimation. Threat assessment. (environment, intel). Adaptive Predictive. Controller. Mobile robot tasking. Static sensor operation ...

International Nuclear Information System (INIS)

This document contains a summarization of the results and insights from the Level 1 accident sequence analyses of internally initiated events, internally initiated fire and flood events, seismically initiated events, and the Level 2/3 risk analysis of internally initiated events (excluding fire and flood) for Surry, Unit 1. The analysis was confined to mid-loop operation, which can occur during three plant operational states (identified as POSs R6 and R10 during a refueling outage, and POS D6 during drained maintenance). The report summarizes the Level 1 information contained in Volumes 2--5 and the Level 2/3 information contained in Volume 6 of NUREG/CR-6144.

UK PubMed Central (United Kingdom)

BackgroundThe permeabilization of mitochondrial membranes is a decisive event in apoptosis or necrosis culminating in cell death. One fundamental mechanism by which...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Paget Schroetter syndrome, or effort thrombosis of the axillosubclavian venous system, is distinct from other forms of upper limb deep vein thrombosis. It occurs in younger patients and often is secondary to competitive sport, music, or strenuous occupation. If untreated, there is a higher incidence of disabling venous hypertension than was previously appreciated. Anticoagulation alone or in combination with thrombolysis leads to a high rate of rethrombosis. We have established a multidisciplinary protocol over 15?years, based on careful patient selection and a combination of lysis, decompressive surgery, and postoperative percutaneous venoplasty. During the past 10?years, a total of 232 decompression procedures have been performed. This article reviews the literature and presents the Exet...

British Library Electronic Table of Contents (United Kingdom)

Background:- Discrepancies exist in optometric education, practice and regulation across the Asia-Pacific region and the competence of optometric practitioners in adopting new lens technologies may vary widely. Over the past 10-years, a continuing professional development program, Varilux Academy Asia-Pacific (VAAP), was implemented and conducted in countries across the Asia-Pacific region to improve practitioners' understanding of optometric fitting principles, with special emphasis on progressive addition lenses (PAL). The aim was to demonstrate the effectiveness of VAAP and to compare the competence of practitioners across the Asia-Pacific region in new lens fitting technologies. Methods:- From 2002 to 2008, all VAAP participants from 12 countries across Asia-Pacific were invited to com...

Energy Technology Data Exchange (ETDEWEB)

The Superphenix 750-MW (thermal), once-throughtype steam generators are the result of over 10 years of intensive research and development. Detailed design and manufacture of the components lasted from 1977 to 1982. The main difficulties encountered during the construction of these prototype units concerned: demonstration of satisfactory high-temperature properties of Alloy 800 tubes; proven resistance of tube welds to thermal fatigue and of structures and shells to sodium/ water reaction effects; prevention of the tube bundle to flow-induced vibration; necessity of manual welding of shells to prevent hot cracking hazards related to the boron content of the steel; and welding of heat exchange tubes. None of these difficulties, however, invalidated initial major design choices, but provided a wealth of technical and technological experience and knowledge for the steam generators of the future. Plans for the future include revision of the ...

International Nuclear Information System (INIS)

Twenty-four long-term survivors of Ewing's sarcoma were identified as being at risk for a second primary tumor. Among this group of patients followed from 3 to 22 y, 4 new bone tumors were observed, whereas 1.2 x 10"-"3 were expected. All new tumors arose in heavily irradiated areas. The risk associated with radiation after 3 years was 7.2 cases/million person-years per rad. The cumulative cancer risk over 10 years for irradiated patients was 35% (SE, 15.1%). Intensive chemotherapy (cyclophosphamide and vincristine administered in five or more courses) seemed to exert an enhancing effect, increasing the rate of development of new tumors.

Energy Technology Data Exchange (ETDEWEB)

Adding capacity to coal-fired plants in small increments of an overall integrated program may be the solution to the 10-year lead time required for the construction of a new plant. A preliminary study evaluates the technical and economic feasibility of a modular natural gas and coal-fired combined-cycle power plant which can be installed in three distinct phases. The plant sizes are suitable for large industrial and utility applications. The Modular Block Power Plant (MBPP) concept offers the advantages of phase construction, lower capital cost, lower cost electricity, lower air emissions, lower water requirements, and reduced solid waste discharge. Other advantages include part load availability, reduced coal inventory requirements, and easier plant siting. 11 figures, 4 tables.

Energy Technology Data Exchange (ETDEWEB)

This paper discusses organizational models of planning technology development in coal mining. The following 4 planning systems are analyzed: all-union national system coordinated by the Ministry of Coal Mining of the USSR, all-union associations of coal mine associations (in the Ukrainian SSR the plan is developed by the Ministry of Coal Industry of the Republic), associations of coal mines, coal mines or groups of coal mines. Methods for developing programs for technology development at 4 levels are reviewed. The following planning periods are used: 10 years or more (from 1980 to 1990), a 5 year period and a 1 year period. System for technology development in the Soviet coal industry from 1981 to 1985 is evaluated: research and development programs (20 comprehensive state programs, 36 branch programs). (In Russian)

British Library Electronic Table of Contents (United Kingdom)

Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...

British Library Electronic Table of Contents (United Kingdom)

Objective: Analyse the difference in school careers and secondary school qualification levels between unilateral hearing aid users and bilateral hearing aid users. Study design: Retrospective questionnaire study. Setting: Postal-based questionnaire. Participants: Names of adults known to have been fitted with unilateral or bilateral hearing aids during childhood were retrieved. This resulted in 292 names. Participants were selected using the following criteria: availability of the medical record, presence of bilateral hearing loss, completed secondary school education, normal IQ and a minimum aided word-recognition score of 70% at 10 years of age. The questionnaire was sent to 50 potential participants of whom 40 responded, resulting in two groups comprising 19 unilateral and 21 bilateral ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Remediation of ground water containing anionic contaminants presents a great challenge. Because of its low cost, surfactant-modified zeolite (SMZ) has been studied for >10 years for potential uses as permeable barrier materials to remove anionic contaminants from water. In this study, zeolite aggregates with particle size of 3.4 to 4.8 mm were modified by hexadecyltrimethylammonium (HDTMA) bromide, a cationic surfactant, to a surfactant loading level of 80 mmol/kg and a concurrent counterion bromide loading level of 34 mmol/kg. While no retardation of chromate transport was observed for unmodified columns, a retardation factor of 60 was found for chromate transport through the SMZ columns. Slow but persistent desorption of HDTMA occurred throughout the chromate transport experimen...

Energy Technology Data Exchange (ETDEWEB)

The assessment and control of fetal exposure to radiation in the workplace is an issue that is complicated by both biological and political/social ramifications. As a result of the dramatic increase in the number of women employed as radiation workers during the past 10 years, many facilities using radioactive materials have instituted fetal protection programs with special requirements for female radiation workers. It is necessary, however, to ensure that any fetal protection program be developed in such a way as to be nondiscriminatory. A study has been initiated whose purpose is to balance the political/social and the biological ramifications associated with occupational protection of the developing embryo/fetus. Several considerations are involved in properly balancing these factors. These considerations include appropriate methods of declaring the pregnancy, training workers, controlling the dose to the embryo/fetus, measuring and ...

CERN Document Server

This survey paper categorises, compares, and summarises from almost all published technical and review articles in automated fraud detection within the last 10 years. It defines the professional fraudster, formalises the main types and subtypes of known fraud, and presents the nature of data evidence collected within affected industries. Within the business context of mining the data to achieve higher cost savings, this research presents methods and techniques together with their problems. Compared to all related reviews on fraud detection, this survey covers much more technical articles and is the only one, to the best of our knowledge, which proposes alternative data and solutions from related domains.

British Library Electronic Table of Contents (United Kingdom)

C-type natriuretic peptide (CNP) is a member of the small family of natriuretic peptides that also includes atrial natriuretic peptide (ANP) and brain, or B-type natriuretic peptide (BNP). Unlike them, it performs its major functions in an autocrine or paracrine manner. Those functions, mediated through binding to the membrane guanylyl cyclase natriuretic peptide receptor B (NPR-B), or by signaling through the non-enzyme natriuretic peptide receptor C (NPR-C), include the regulation of endochondral ossification, reproduction, nervous system development, and the maintenance of cardiovascular health. To date, the regulation of CNP gene expression has not received the attention that has been paid to regulation of the ANP and BNP genes. CNP expression in vitro is regulated by TGF-b and recepto...

British Library Electronic Table of Contents (United Kingdom)

Hypertension is one of the most important modifiable risk factors for cardiovascular and cerebrovascular diseases. We investigated the potential antihypertensive effect of the purple passion fruit peel (PFP) extract, a mixture of bioflavonoids, phenolic acids, and anthocyanins, in spontaneously hypertensive rats and human. A high-performance liquid chromatography analysis was performed to identify the active ingredients of the PFP extract. In a rat liver toxicity assay, no hepatotoxicity was observed after 9 hours incubation in the presence of PFP extract (20 ?g/mL). The PFP extract also revealed hepatoprotection against chloroform (1 mmol/L)-induced liver injury. In the experimental model, 24 spontaneously hypertensive rats were divided into 3 treatment groups for a period of 8weeks: cont...

British Library Electronic Table of Contents (United Kingdom)

Bariatric surgical procedures have become important therapeutic options for treatment of morbid obesity in both adults and adolescents co-morbidities of obesity such as glucose intolerance, type 2 diabetes (T2DM), metabolic syndrome, steatohepatitis, hyperlipidemia and cardiovascular disease. These co-morbidities of obesity have significant impacts on the overall quality of life of the individual and our society at large. Roux-en-Y gastric bypass (RYGB) and the relatively newer procedures of gastric banding (GB) and vertical sleeve gastrectomy (VSG) have proven to be efficacious in achieving rapid weight loss and reversing the comorbidities of obesity. Unfortunately, bariatric procedures are not without risks including micronutrient deficiency, failure to maintain lost weight, and mortalit...

Energy Technology Data Exchange (ETDEWEB)

Certain fluorocarbons, such as difluorodichloromethane (FC 12), depress the cardiovascular system by diminution of all the transmembrane ionic conductances in cardiac tissues. Does FC 12 also inhibit active transport and thus enzymatic activity and cellular energy. We measured phosphocreatine (PC), adenosine triphosphate (ATP) and cyclic adenosine monophosphate (AMPc) in rat hearts. Rats were randomly divided into 4 groups; 2 control groups: one breathing a mixture of oxygen (21%) and nitrogen (79%) (group C) and the other breathing the same mixture but simultaneously perfused with 1 microgram/kg/min. epinephrine (groupe E-C); 2 trial groups T and E-T where nitrogen was replaced by FC 12. The maximal FC 12 concentration of 720 micrograms/ml in arterial blood produced no significant difference in the concentrations of these three metabolites compared with controls.

International Nuclear Information System (INIS)

The aim of this article is to report our experience in the diagnosis of two cases of iliac artery endofibrosis or arteriopathy, a rare entity occurring in high-performance athletes, presenting with intermittent claudication (right-sided in both) after maximal exercise. External iliac artery endofibrosis or arteriopathy is a likely diagnosis in competitive athletes free of cardiovascular risk factors who present with leg claudication. Arteriography and a papaverine-assisted mean pressure gradient across the iliac arteries of more than 10 mmHg is a useful diagnostic approach. Moreover, balloon angioplasty of the iliac artery in that patient, in whom a pressure gradient was detected, resulted in symptomatic relief for 2 months followed by mild symptom recurrence. Thus, although balloon angioplasty is feasible and safe, it might not be adequate to treat this entity and, thus, its value remains undefined.

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground Few published data are available on the benefits of aspirin use in patients with unstable angina (UA). Hypothesis Aspirin use carries a mortality benefit in a population-based cohort of patients presenting with UA. Methods All residents of Olmsted County, Minnesota presenting to local emergency departments with acute chest pain from January 1985 through December 1992 having symptoms consistent with UA were identified through medical records. A total of 1628 patients were identified with UA and were stratified by aspirin use in-hospital and at discharge. Cardiovascular mortality and nonfatal myocardial infarction and stroke were assessed over a median of 7.5 years follow-up and all-cause mortality data over a median of 16.7 years. The mean age of patients with UA was 65 y...

British Library Electronic Table of Contents (United Kingdom)

Abstract Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our society today. The aim of the integrated genome research network -Genetics of Alcohol Addiction--which is a German inter-/trans-disciplinary life science consortium consisting of molecular biologists,...

International Nuclear Information System (INIS)

Single-event burnout (SEB) sensitivity was tested for power MOSFET devices, JTMCS081 and JTMCS062, which were made in Institute of Microelectronics, Chinese Academy of Sciences, using californium-252 simulation source. SEB voltage threshold was found for devices under test (DUT). It is helpful for engineers to choose devices used in satellites. (authors)

International Nuclear Information System (INIS)

Events detected in a shielded plastic scintillation counter occurring in the 26 microsec preceding the arrival of an extensive air shower at ground level with local electron density or = 20 m to the -2 power and the 240 microsec after its arrival have been studied. No significant excess of events (tachyons) arriving in the early time domain have been observed in a sample of 11,585 air shower triggers.

Energy Technology Data Exchange (ETDEWEB)

The purpose of this report is to provide a brief overview and bibliography of those techniques that may have application for the evaluation of a site to determine if a high energy release event is nuclear in nature. This effort is motivated by recognition of the changing world political climate and the perception that low yield and non-proliferation issues will grow in importance as countries become increasingly involved as signators to treaties that are intended to limit the development and testing of nuclear weapons. Along with an increasing interest in such issues is the awareness of the need to implement improved capabilities for treaty monitoring programs that must deal with assessing suspicious occurrences of high energy release events. In preparing this report, it is recognized that monitoring can take two main forms. The first involves the resolution of unidentified events detected by seismic and satellite National ...

Energy Technology Data Exchange (ETDEWEB)

An experiment to synthesize element 110 by the {sup 59}Co+{sup 209}Bi reaction has bee performed at the SuperHILAC at the Lawrence Berkeley Laboratory. One event with many of the expected characteristics of a successful of {sup 267}110 was observed. This event corresponds to a production cross section of about one picobarn.

International Nuclear Information System (INIS)

The human causal factors for all human error licensing operational events on Daya Bay nuclear power station since 1993 to 2003 are categorized, the trend of these causal factors is analyzed. The emphasis is placed on analyzing the deficiencies on complying with and executing regulations and procedures. The results provide directional reference for nuclear power station to improve human performance. (author)

Energy Technology Data Exchange (ETDEWEB)

During the past 10 years, five infants with Kasabach-Merritt syndrome (K-M) receiving radiation therapy were reported. We investigated whether radiation therapy for K-M was useful and what the unfavorable factors of K-M were. During the past 10 years, we have treated five infants with K-M. The syndrome occurred at ages ranging from birth to 4 months. The incidence of female to male ratio was 3:2. Among 5 cases, the site of hemangioma was as follows; shoulder, anterior chest wall, lower abdominal wall, face and neck and inguinal site. All 5 cases received medication to control the coagulopathy including prednisone and blood transfusion at first. Because the platelet count and the bleeding tendency did not improve in any case, these cases received radiation therapy. Total dose ranged from 5 to 10 Gy and fraction-size ranged from 0.5 to 1.75 Gy. Irradiation session was 2 or 3 times per week. In 5 cases, 4 ...

International Nuclear Information System (INIS)

On the basis of soil losses records during 10 years, three levels of water erosion were established for two soil (Typical Hapludox and Oxic Dystropept) located on high and medium terraces of alluvial flat plain of piedmont in the Eastern Plains in La Libertad Research Center of CORPOICA. Eighteen 3 x 10 m"2 run-off plots were fitted out on a nonrandom arrangement of nine plots by landscape and three soil use and management treatments: zero grazing Brachiaria decumbens pasture for six years, up land rice, soybean and maize rotations for six years and bare soil for 10 years. Soil losses under these treatments allowed to define three degrees of erosion: slight (N_3 moderate (N_2) and severe (N_3) respectively. From each plot soil samples were taken at two depths for physical analyses. infiltration and resistance to cone penetration were measured in the field. Without exception water erosion produced a ...

International Nuclear Information System (INIS)

Background and purpose: Local treatment for non-metastatic Ewing's sarcoma family tumors (ESFTs) is controversial. Results achieved in a single institution in patients with ESFT of the humerus are presented. Materials and methods: Patients treated between 1983 and 2000 for ESFT of the humerus were included. The impact of local treatment (surgery, radiotherapy or both) on outcome was assessed. Results: 55 patients: 34 males (62%); 21 females (38%); mean age: 17.9 (range: 3-40). Local treatment: surgery in 27 patients (49%), radiotherapy in 17 (31%) and surgery followed by radiotherapy in 11 (20%). After a mean follow-up of 15 years (range: 7-25 years), 27 patients (49%) remained continuously disease free, 27 (49%) relapsed and one died of chemotherapy toxicity. The local recurrence rate was 13% overall: 18% (3/17) after radiotherapy, 7% (2/27) after surgery and 19% (2/11) after surgery followed by adjuvant radiotherapy (p = ns). On the contrary, the ...

Energy Technology Data Exchange (ETDEWEB)

The staff of the Spent Fuel Project Office at the U.S. Nuclear Regulatory Commission undertook the investigation and thermal analysis of the Baltimore tunnel fire event. This event occurred in the Howard Street tunnel, in Baltimore, Maryland, on July 18, 2001. The staff was tasked with assessing the consequences of this event on the transportation of spent nuclear fuel. This paper describes the staff's coordination with the following government and laboratory organizations: the National Transportation Safety Board (NTSB), to determine the details of the train derailment and fire; the National Institute of Standards and Technology (NIST), to quantify the thermal conditions within the tunnel; the Center for Nuclear Waste Regulatory Analysis (CNWRA), to validate the NIST evaluations, and the Pacific Northwest National Laboratory (PNNL), to assist in the thermal analysis. The results of the staff's review and ...

Science.gov (United States)

Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP). Natriuretic peptides play an important role in the regulation of cardiovascular homeostasis maintaining blood pressure and extracellular fluid volume. The classical endocrine effects of natriuretic peptides to modulate fluid and electrolyte balance and vascular smooth muscle tone are complemented by autocrine and paracrine actions that include regulation of coronary blood flow and, therefore, myocardial perfusion; modulation of proliferative responses during myocardial and vascular remodeling; and cytoprotective anti-ischemic effects. The actions of natriuretic peptides are mediated by the specific binding of these peptides to three cell surface receptors: type A natriuretic peptide receptor (NPR-A), type B natriuretic peptide receptor (NPR-B), and type C natriuretic ...

International Nuclear Information System (INIS)

The IAEA Assessment of Safety Significant Events Team (ASSET) report presents the results of an ASSET team's assessment of their investigation of the effectiveness of the plant for prevention of incidents since 1990 at Zaporozhe nuclear power plant. The results, conclusions and suggestions presented herein reflect the views of the ASSET experts. They are provided for consideration by the responsible authorities in Ukraine. The ASSET team's views presented in this report are based on visits to the plant, on review of documentation made available by the operating organization and on discussions with utility personnel. The report is intended to enhance operational safety at Zaporozhe by proposing improvements to the policy for the prevention of incidents at the plant. The report includes, as a usual practice, the official response of the operating organization as well as of the regulatory body to the ASSET recommendations. Figs.

Energy Technology Data Exchange (ETDEWEB)

Real-time neutron radiography (RTNR) is now proving to be a valuable research tool in the study of hydrogenous fluid flow. One of the most significant advantages of neutron radiography is the ability to image hydrogenous substances (such as lubricants, coolants, and fuels) inside metallic materials such as aluminum and titanium engines. By using RTNR, one can then study dynamic events such as the movement of liquids inside these solids. The Phoenix Memorial Laboratory (PML) at the University of Michigan has recently developed and installed a facility dedicated to RTNR. The work at PML has shown that RTNR of dynamic events can provide information enabling the researcher to follow dynamic events that were previously impossible or impractical. This paper will show the variety of uses of RTNR presently being pursued at PML.

CERN Document Server

The ATLAS High Level Trigger (HLT) is a distributed real-time software system that performs the final online selection of events produced during proton-proton collisions at the Large Hadron Collider (LHC). It is designed as a two-stage trigger and event filter running on a farm of commodity PC hardware. Currently the system consists of about 850 processing nodes and will be extended incrementally following the expected increase in luminosity of the LHC to about 2000 nodes. The event selection within the HLT applications is carried out by specialized reconstruction algorithms. The selection can be controlled via properties that are stored in a central database and are retrieved at the startup of the HLT processes, which then usually run continuously for many hours. To be able to respond to changes in the LHC beam conditions, it is essential that the algorithms can be re-configured without disrupting data taking while ...

British Library Electronic Table of Contents (United Kingdom)

The Real-Time Specification for Java (RTSJ) is silent on multiprocessor issues. It attempts not to preclude multiprocessor implementations but provides no direct support. Many areas of the RTSJ leave an implementation considerable freedom on how it provides the defined functionality. One such area is the asynchronous event handling (AEH) model. Events are fired and associated handlers are scheduled for execution in response; handlers have defined scheduling parameters and deadlines. The primary goal of the AEH model is to support a lightweight real-time concurrency model. Hence handlers, in general, do not have dedicated threads. Rather, the implementation is responsible for ensuring that all handlers meet their deadlines. Typically real-time threads are assigned to execute handlers by the...

British Library Electronic Table of Contents (United Kingdom)

ARIES-AT is a 1000MWe conceptual fusion power plant design with a very low projected cost of electricity. The design contains many innovative features to improve both the physics and engineering performance of the system. From the safety and environmental perspective, there is greater depth to the overall analysis than in past ARIES studies. For ARIES-AT, the overall spectrum of off-normal events to be examined has been broadened. They include conventional loss of coolant and loss of flow events, an ex-vessel loss of coolant, and in-vessel off-normal events that mobilize in-vessel inventories (e.g., tritium and tokamak dust) and bypass primary confinement such as a loss of vacuum and an in-vessel loss of coolant with bypass. This broader examination of accidents improves the robustness of ...

UK PubMed Central (United Kingdom)

Growing evidence suggests the Wnt family of secreted glycoproteins and their associated signaling pathways, linked to development, are recapitulated during wound repair and regeneration events. However,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This paper is concerned with the validation of the 3D deterministic neutral-particle transport theory code EVENT for shielding applications. The code is based on the finite element-spherical harmonics (FE-P{sub N}) method which has been extensively developed over the last decade. A general multi-group, anisotropic scattering formalism enables the code to address realistic steady state and time dependent, multi-dimensional coupled neutron/gamma radiation transport problems involving high scattering and deep penetration alike. The powerful geometrical flexibility and competitive computational effort makes the code an attractive tool for shielding applications. In recognition of this, EVENT is currently in the process of being adopted by the UK nuclear industry. The theory behind EVENT is described and its numerical implementation is outlined. Numerical results obtained by the code are compared with predictions of the Monte ...

UK PubMed Central (United Kingdom)

To study the topographical organization of mu and beta band event-related desynchronization (ERD) associated with voluntary hand and foot movements, we used magnetoencephalographic (MEG) recordings...Full Text Available

UK PubMed Central (United Kingdom)

Pooling and synthesizing signals across different senses often enhances responses to the event from which they are derived. Here we examine whether multisensory response enhancements are attributable...Full Text Available

Science.gov (United States)

... Figure 5. Distribution of standard deviation computed from N events Page 18. ... t- OJ o o o to to to o (S99J69P) QI0V 01 3AllV"I3a Hinwizv Page 20. ...

Science.gov (United States)

In addition I have had many years been cooking for Scouts fund-raising events and a hundred and one sausage sizzles so I can find my way around a cooktop. ...

UK PubMed Central (United Kingdom)

[1] Independent data from the Gulf of Mexico are used to develop and test the hypothesis that the same sequence of physical and ecological events each year allows the toxic dinoflagellate Karenia...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveTo test whether a disclosure intervention improves subjective health and reduces medical consumption and sick leave in somatising patients in general practice.DesignNon-blind...Full Text Available

UK PubMed Central (United Kingdom)

Petal senescence, one type of programmed cell death (PCD) in plants, is a genetically controlled sequence of events comprising its final developmental stage. We characterized the pollination-induced...Full Text Available

UK PubMed Central (United Kingdom)

Background:Falls have been identified as a potential adverse event associated with the administration of psychotropic medications to older patients.Objective:The...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe exploitation of information extraction (IE), a technology aiming to provide instances of structured representations from free-form text, has been rapidly growing within...Full Text Available

Science.gov (United States)

Federated Search (openSearch) (C. Lynnes); Infusion Process (S. Olding) Metrics Planning & Reporting (R. Ramapriyan); Service & Event Casting (B. Wilson) ...

Science.gov (United States)

at 4:30 P.M. November 30, 2006 - NTSB Sends Investigators to Metro Accident in Alexandria, Virginia November 27, 2006 - (SB-06-67) John Clark Assumes New Scientific Post at...

Energy Technology Data Exchange (ETDEWEB)

This document is a biography of the renowned nuclear chemist, Glenn T. Seaborg. It covers his career over the presidential terms of Franklin Roosevelt through George Bush. It contains many personnel accounts of historic events. Photographs of Seaborg and the various Presidents are presented.

Wastenet

...PROJECTS We are funded by industry, public bodies, charities and research councils and we are proud of the research projects undertaken by our world-class research groups . Research News To read more about our latest research to hit the media go to our News & Events page ...

UK PubMed Central (United Kingdom)

The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation and fusion. Despite recent advances in the field of palate development, the process...Full Text Available

UK PubMed Central (United Kingdom)

Circuit modification associated with learning and memory involves multiple events, including the addition and remotion of newborn cells trough adulthood. Adult neurogenesis and gliogenesis were mainly...Full Text Available

UK PubMed Central (United Kingdom)

Path analysis was used to determine the interrelationships between postpartum administration of gonadotrophin releasing hormone and cloprostenol and the occurrence of reproductive disease and reproductive...Full Text Available

Medline Plus

... Mission Research Local Events Advocacy Professional Resources Privacy policy Welcome Back! Use your existing or March for ... or email address Password Forgot username/password Privacy policy Welcome Back! Enter your e-mail address to ...

Science.gov (United States)

Jul 16, 2011 ... The standard filtering applies to all the existing distribution methods/media. ... needed to allow your data point(s) to be added to the MOA lightcurve. .... name="t1" value="0.00" unit="sigma" ucd="stat.snr" />

UK PubMed Central (United Kingdom)

AimsTo determine the effect of exercise training on clinical events and health-related quality of life (HRQoL) of patients with systolic heart failure.Methods...Full Text Available

UK PubMed Central (United Kingdom)

Linking biological samples found at a crime scene with the actual crime event represents the most important aspect of forensic investigation, together with the identification of the sample donor. While...Full Text Available

Science.gov (United States)

Recommended ERLs for whole body, thyroid, lung and other single organs are presented in tabular form, and related to the relevant counter measures such as evacuation, sheltering, distribution of stable iodine tablets, etc. Application of ERLs to local env...

UK PubMed Central (United Kingdom)

Soybean (Glycine max) is a paleopolyploid whose genome has gone through at least two rounds of polyploidy and subsequent diploidization events. Several studies have investigated the...Full Text Available

UK PubMed Central (United Kingdom)

Metazoan life cycles can be complex in different ways. A number of diverse phenotypes and reproductive events can sequentially occur along the cycle, and at certain stages a variety of developmental...Full Text Available

UK PubMed Central (United Kingdom)

Realization that dental caries is a reversible, dynamic biochemical event at a micron level has changed the way the profession recognizes the caries disease and the caries lesion. The diagnosis of dental...Full Text Available

UK PubMed Central (United Kingdom)

Sentinel species such as bottlenose dolphins (Tursiops truncatus) can be impacted by large-scale mortality events due to exposure to marine algal toxins. In the Sarasota Bay region...Full Text Available

UK PubMed Central (United Kingdom)

There are many methods to screen for abnormal amounts of proteinuria to identify patients at risk for progression of renal disease, but which method best predicts renal risk is unknown. Here, we analyzed...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundEmbolic events (EE) in infective endocarditis (IE) are caused by fragmentation of vegetations or valvular tissue. Vegetation length is considered to be the most potent...Full Text Available

UK PubMed Central (United Kingdom)

RNA is involved in a variety of chromatin modification events, ranging from large-scale structural rearrangements to subtle local affects. Here, we extend the evidence for RNA–chromatin interactions...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The commissioning of four CANDU-600 reactors is discussed, with mention of some design features. The four are Point Lepreau, Gentilly-2, Wolsung and Cordoba reactors. The commissioning of Pickering-5 is also mentioned, and so are some events affecting other CANDU reactors.

International Nuclear Information System (INIS)

In order to evaluate the integrated performance of RELAP5/MOD3/CANDU"+ for CANDU operational transient analysis, we assesed the code to the D_2O leakage event occurred at Wolsung-I, 600 MW(e) CANDU reactor, on Oct. 20, '94. D_2O leakage event was initiated by stuck opening of liquid relief valve No.4 in primary coolant pressure and level control system. Assessment calculation was performed for the plant transients up to 1000 seconds after the initiating event. Calculation results are compared with those measured in primary heat transport system, pressure and inventory control system and boiler secondary system. Comparison with the plant trip log shows that the RELAP5/CANDU"+ is able to simulate the plant transients properly, from which we can conclude that the RELAP5/CANDU"+ is validated for application to CANDU operational transient analysis. CANDU specific models used in the assessment are fuel bundle heat transfer model, ...

UK PubMed Central (United Kingdom)

Platelet Factor VIII-related antigen (VIIIR:Ag) represents a significant proportion of the total circulating VIIIR:Ag pool. However, its participation in the events of primary hemostasis has not been...Full Text Available

UK PubMed Central (United Kingdom)

The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium tuberculosis,...Full Text Available

UK PubMed Central (United Kingdom)

Two related questions critical to understanding the predictive processes that come online during sentence comprehension are 1) what information is included in the representation created through...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In future experiments the readout electronics for pixel detectors is required to be resistant to a very high radiation level. In this paper we report on irradiation tests performed on several preFPIX2 prototype pixel readout chips for the BTeV experiment exposed to a 200 MeV proton beam. The prototype chips have been implemented in commercial 0.25 {micro}m CMOS processes following radiation tolerant design rules. The results show that this ASIC design tolerates a large total radiation dose, and that radiation induced Single Event Effects occur at a manageable level.

International Nuclear Information System (INIS)

Field Programmable Gate Arrays (FPGAs) are being used in space applications because of attractive attributes: good density, moderate speed, low cost, and quick turn-around time. However, these devices are susceptible to Single Event Upsets (SEUs). An approach using triple modular redundancy (TMR) and feedback was developed for flip-flop hardening in these devices. Test data showed excellent results for this circuit topology. Total dose and Single Event Effect (SEE) testing have been performed on recently released technologies. Failures are analyzed and test methodology is discussed.

Science.gov (United States)

We disclose the behavior of quantum and classical correlations among all the different spatial-temporal regions of a space-time with an event horizon, comparing fermionic with bosonic fields. We show the emergence of conservation laws for entanglement and classical correlations, pointing out the crucial role that statistics plays in the information exchange (and more specifically, the entanglement tradeoff) across horizons. The results obtained here could shed new light on the problem of information behavior in noninertial frames and in the presence of horizons, giving better insight into the black-hole information paradox.

International Nuclear Information System (INIS)

The ability of the Packard 2000 CA/LL liquid scintillation counter to reduce background count rates relies on pulse shape/duration analysis in which short duration organic scintillation events are discriminated from longer duration non-quenchable background events. A consequence of this is a loss in the counting efficiency. The results of this investigation indicate that much of the lost efficiency can be regained by sharpening the true #beta#"- pulse widths via the use of different scintillant combinations and by certain counter modifications. (author).

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We study heavy physics effects on the Higgs production in {gamma}{gamma} fusion using the effective Lagrangian approach. We find that the effects coming from new physics may enhance the standard model predictions for the number of events expected in the final states {bar {ital b}}{ital b}, {ital WW}, and {ital ZZ} up to one order of magnitude, whereas the corresponding number of events for the final state {bar {ital t}}{ital t} may be enhanced up to two orders of magnitude. {copyright} {ital 1996 American Institute of Physics.}

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We present methods to measure the beam polarizations and the luminosity of [gamma][gamma] colliders at TeV energy scale. The beam polarizations of a [gamma][gamma] collider can easily be monitored by comparing the numbers of events of the processes [gamma][gamma] [yields] l[sup +]l[sup -] and [gamma][gamma] [yields] W[sup +] W[sup -], where l means e or [mu]. The luminosity of a [gamma][gamma] collider is also measurable by the event rate of W boson pair productions and the light lepton pair productions. (orig.)

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We describe a position-sensitive event-counting microchannel plate detector with a quadrant anode readout system that combines the advantages of several centroid-finding readout techniques. The relative amount of charge collected by each quadrant of the anode mounted behind the output side of the microchannel plate is used to localize each event. The position-sensitive area is about 80% of the active microchannel plate surface. By changing a single voltage a remote-controlled image magnification can be achieved. Due to a correction function that minimizes image distortions the imaging characteristics of this low-cost readout system are similar to those of expensive resistive anodes.

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This document contains the accident sequence analysis of internally initiated events for Grand Gulf, Unit 1 as it operates in the Low Power and Shutdown Plant Operational State 5 during a refueling outage. The report documents the methodology used during the analysis, describes the results from the application of the methodology, and compares the results with the results from two full power analyses performed on Grand Gulf.

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This report considers the effect of pipe-whip restraints and snubbers on the normal operation of piping systems in nuclear power plants. Also considered are the effect of these postulated event devices on reliability, economics, and the exposure of plant personnel to radiation. Field data were gathered from three nuclear power plants that had applied for Operating Licenses. Criteria, design philosophies, and data were obtained from the respective nuclear steam system suppliers, architects-engineers and utilities.

Science.gov (United States)

We describe a position-sensitive event-counting microchannel plate detector with a quadrant anode readout system that combines the advantages of several centroid-finding readout techniques. The relative amount of charge collected by each quadrant of the anode mounted behind the output side of the microchannel plate is used to localize each event. The position-sensitive area is about 80% of the active microchannel plate surface. By changing a single voltage a remote-controlled image magnification can be achieved. Due to a correction function that minimizes image distortions the imaging characteristics of this low-cost readout system are similar to those of expensive resistive anodes.

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The natural gas industry has proposed an increase in the DOE gas R&D budget from about $100 million to about $250 million per year for each of the next 10 years. The proposal includes four programs: natural gas supplies, fuel cells, natural gas vehicles and stationary combustion systems. This paper is a qualitative assessment of the gas industry proposal and recommends a natural gas R&D strategy for the DOE. The methodology is a conceptual framework based on an analysis of market failures and the energy policy objectives of the DOE`s (1991) National Energy Strategy. This framework would assist the DOE in constructing an R&D portfolio that achieves energy policy objectives. The natural gas supply program is recommended to the extent that it contributes to energy price stability. Stationary combustion programs are supported on grounds of economic efficiency and environmental quality. The fuel cell program is supported on grounds of ...

International Nuclear Information System (INIS)

Assessment on the back end fuel cycle, in PEACER (Proliferation-resistant Environmental-friendly Accident-tolerant Continuable and Economical Reactor) that was designated as a new transmutation concept, was performed. Recovery system of uranium and TRU for PEACER is based on pyroprocessing. In the assessment of Long-Lived Fission Products (LLFP) wastes, initially "9"0Sr and "1"3"7Cs are dominant contributor nuclides until 30 years and especially "9"0Sr and "1"3"7Cs have the highest activity and decay heat than other LLFP. In this study, recovery of "9"0Sr and "1"3"7Cs is recommended for reducing of wastes loading. The acceptable decontamination factor is investigated by the toxicity of PEACER spent fuel. The acceptable decontamination factor is about 1.02E+05 for the actinides from PEACER spent fuel after 10 years cooling, 4.26E+05 after 100 years cooling, 1.97E+04 after 300 years cooling, 9.52E+03 after 1000 years cooling.

International Nuclear Information System (INIS)

The outcome was retrospectively examined and prognostic factors were discussed for arterial chemo-infusion therapy (ACT) through an implanted reservoir system and radiation therapy (RT) in patients with unresectable intrahepatic cholangiocarcinoma (CCC). ACT plus RT were conducted to 25 patients (mean age 61.7 y, M/F 12/13, stage III-IVB) during 10 years from 1996 to 2005 with various regimens of cisplatin (CDDP), 5- fluorouracil (FU), epirubicin (FARM), mitomycin C (MMC) plus 39-50 Gy of radiation in a fractionated manner partly involving internal RT (2 cases, 15 Gy) and RT for metastatic bone (1, 25 Gy). The survival rates at 1, 2 and 3 years after ACT+RT were respectively 52.5, 43.7 and 28.1%; total efficacy (PR) was 36% (9/25) at 6 months; and significantly good prognostic factors were found to be female and absence of metastasis remote and/or lymphatic around artery. Authors concluded that ACT+RT was a meaningful treatment for highly ...

Science.gov (United States)

All Streptococcus pneumoniae strains isolated from paediatric clinical samples at Heraklion University General Hospital in the 10-year period 2000-2009 were tested for serotype and susceptibility to antimicrobials. Among a total of 258 strains, 159 were isolated in the 5-year period 2000-2004, before the introduction of the heptavalent pneumococcal conjugate vaccine (PCV7), and 99 in the post-PCV7 5-year period 2005-2009. The prevalence of PCV7-included serotypes decreased in the post-PCV7 period (p?=?0.0002), but an increase was observed for serotypes 7F (p?=?0.002) and 19A (p?=?0.004). Pan-susceptibility rates and susceptibility to cotrimoxazole increased in the post-PCV7 period (p?=?0.01 and p?=?0.008, respectively), but serotype 19A emerged as a contributor to multi-resistance (p?=?0.007). PCV7 was followed by decreased S. pneumoniae resistance and prevalence of vaccine-related serotypes but increased prevalence of serotypes 7F and 19A. ...

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Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively. Though the initial result of the bulbocavernosus graft was obviously better, in many of the local repair procedures, subclinical radiation damage progressed, resulting in recurrence of rectovaginal fistula (5), rectovesical fistula (4), pararectal abscess (2) etc. After a mean follow up of around 10 years, the success rate of fistula repair decreased to 5/9 and 13/14 and only 2/9 and 6/14 finally remained without a colostomy. A local repair operation should be restricted to carefully selected cases. The musculus gracilis is proposed as a better vascular graft. If the general condition of the patient does not allow more aggressive reconstructive ...

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Reducing conditions are periodically present in hydric soils and are essential for chemical processes that support wetland functions and values. Indicators of these conditions, i.e., redoximorphic features, can be useful in determining the presence of a hydric soil. However, young wetlands, i.e., those recently formed, may not possess reducing conditions and/or may not exhibit redoximorphic features. Few studies have addressed the time needed for hydric soil development. In this study, we present data on redoximorphic features, including chroma and oxidized rhizospheres, gathered from two sets of wetlands in southwestern Virginia, including (1) constructed wetlands that are 3 years old and (2) accidental wetlands that are 10 to 30 years old. Under conditions described for these sites, there is strong evidence that discernable redoximorphic features form in accidental wetlands within 10 years, but not within 3 years in constructed wetlands. ...

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This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study carried out on the Norwegian electricity market 10 years after its liberalisation. The similarity of the Norwegian market to the Swiss electricity market is discussed. Similarly to the proposed situation in Switzerland, the liberalisation in Norway foresaw no privatisation of public utilities and a model for the regulation of grid access was introduced. The report describes and comments on the various phases in which the liberalisation occurred and examines the various instruments used, e.g. to ensure that individual grid operators did not make undue profits from their monopoly. The methods used for the monitoring of grid operators' costs are described and the mechanisms involved in the definition of prices for grid services are examined, including measures taken when profits were too high or too low. The report is concluded with a discussion of ...

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Certain innovative coke-oven repair techniques are reviewed that represent an engineered approach to a successful rehabilitation of all types of coke-oven batteries. These techniques have been developed during the last 10 years and experience gained on a number of repair projects has shown that these techniques operate as a cohesive and comprehensive method of end flue and through-wall repairs to gain additional years of operating life to coke-oven batteries. Extended operations approaching 10 to 15 additional years of service at lower costs than a pad-up rebuild and, while meeting the environmental emission regulations, are attainable using the techniques of: Proper tie-in joint preparation; Improved bricking up methodology; Preheating refractory during bricking up; Installation of spring-loaded bracing system; and installation of flexible coke-oven doors. Repair methods that do not incorporate the above techniques are subject to premature ...

International Nuclear Information System (INIS)

For the purpose of risk estimates from radiation carcinogenesis including leukemogenesis and radiation genetic effects, the biological significant dose is not the tissue kerma in air but the absorbed dose in organ or tissue with respect to carcinogenic and leukemogenic effects or genetic effects. In order to estimate organ or tissue dose from the tissue kerma in air, a ratio of the organ or tissue dose to the tissue kerma in air for survivors in Hiroshima and Nagasaki was calculated with the aid of the Snyder's mathematical phantoms constructed so as to simulate the body shape of survivors aged 5, 10 years old and adult at the time of atomic bomb detonations. The ratios were corrected for the angular distribution of atomic bomb radiations, assuming an anisotropic angular distribution for the survivors exposed to the atomic bombs in open air and the isotropic distribution for the survivors incide a Japanese house or other structures. The ...

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Experience at SRS, ORNL, BNL, and Georgia Institute of Technology involving irradiated aluminum clad fuel and target elements, as well as studies of non-irradiated aluminum indicate that some types of aluminum assemblies can be kept in a continually well-deionized water atmosphere for up to 25 years without problems. SRS experience ranges from 2.75 years for the L-1.1 charge kept in deionized D{sub 2}O{sup 1} to greater than 10 years for assemblies stored in the Receiving Basin for Off-site Fuel (RBOF){sup 2}. Experience at Georgia Institute of Technology reactor in Atlanta yielded the longest value of 25 years without problems. The common denominators in all of the reports is that the water is continually deionized to approximately 2 M{Omega} (2 {times} 10{sup 6}ohms) resistivity and the containers for the water are stainless steel or other non-porous material. This resistivity value is equivalent to a value of 0.5 micromhos or microSiemens ...

International Nuclear Information System (INIS)

Purpose: To describe CT appearances in patients with unilateral cleft lip and palate (CLP) 20 years after bone graft surgery. Material and Methods: Eighteen consecutive patients with unilateral CLP were examined. All patients had been treated with primary closure, both in infancy and early childhood, supplemented with bone grafting at the age of around 10 years. The CT examination of the upper jaw included a dental CT program. The CT appearances of the cleft side were compared with those of the untreated non-cleft side. Results: Abnormal CT appearances included skew nasal aperture (n=17), nasal septal deviation (n=17), low floor of nasal aperture (n=15) at or towards the cleft side, and deviation of anterior nasal spine towards the non-cleft side (n=18). The posterior part of the bone cleft was visible in all patients, and the dental arch was V-shaped in 8. Conclusion: Although adherence to the present treatment protocol is considered to give ...

International Nuclear Information System (INIS)

Daya Bay NPP has been operating safely and stably over 10 years since 1994, and its' seismic analysis of nuclear island was in accordance with the approaches in RCC-G standard for the model M310, in which the Simplified Impedance Matrix Method (SIMM) was employed for the consideration of SSI. Thanks to the rapid progress being made in upgrading the evaluation technology and the capability of data processing systems, methods and software tools for the SSI analysis have experienced significant development all over the world. Focused on the model of reactor building of the Daya Bay NPP, in his paper the more sophisticated 3D half-space continuum impedance method based on the Green functions is used to analyze the functions of the soil, and then the seismic responses of the coupled SSI system are calculated and compared with the corresponding design values. It demonstrates that the design method provides a set of conservatively safe results. The ...

Science.gov (United States)

Up to the present, the generic values of the Common cause failure (CCF) event parameters have been used in most PSA projects for the Korean NPPs. However, the CCF analysis should be performed with plant specific information to meet Category II of the ASME PRA Standard. Therefore, we estimated the Alpha factor parameters of the emergency diesel generator (EDG) for Ulchin Unit 3 by using the International Common-Cause Failure data Exchange (ICDE) database. The ICDE database provides the member countries with only the information needed for an estimation of the CCF parameters. The Ulchin Unit A3, pressurized water reactor, has two onsite EDGs and one alternate AC (AAC) diesel generator. The onsite EDGs of Unit 3 and 4 and the AAC are manufactured by the same company, but they are designed differently. The estimation procedure of the Alpha factor used in this study follows the approach of the NUREG/CR-5485. Since we did not find any qualitative difference between the ...

Science.gov (United States)

The presence of endothelin (ET)-like immunoreactivity and the cardiovascular effects of mammalian ET-1 in fish have been reported. To identify ET-related peptides in fish, we screened the cDNA library of the salmon (Oncorhynchus keta) stomach by means of rapid amplification of cDNA ends, and we cloned cDNAs encoding an ET-related peptide. The salmon ET-related sequence of 21 amino acids is identical to the trout ET-1 peptide recently purified from kidney specimens of Oncorhynchus mykiss. The deduced amino acid sequence of salmon pre-proET-1 (PPET-1) comprises 244 amino acids, including a putative signal sequence and mature ET-1, as well as big ET-1 and ET-1-like sequences. This precursor, the first reported PPET-1 sequence for Salmoniformes, Teleostei, has low homology with the sequences of human, mouse, frog (Xenopus laevis), and zebrafish (Danio rerio) PPET-1 (26%, 29%, 24%, and 39%, respectively). PMID:16740985

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This study sought to quantitate lidocaine's interaction with alpha-1-acid glycoprotein (AAG), human serum albumin (HSA), and AAG in the presence of HSA, and to determine the extent of displacement of lidocaine from its binding site(s) by selected cardiovascular drugs (dipyridamole, disopyramide and quinidine). Since the limited experimental work reported in this area has involved the use of a single lidocaine concentration, this study involved the evaluation of a range of lidocaine concentrations. Lidocaine interaction with plasma proteins (AAG and HSA) was studied at 37/sup 0/C using an isothermal equilibrium dialysis system and /sup 14/C-lidocaine HCl. A dialysis membrane (M.W. cutoff 12,000 to 14,000) separated the two chambers of each dialysis cell. The extent of /sup 14/C-lidocaine dialysis was studied with respect to both drug and protein concentrations. Aliquots of each chamber of each of the cells were subjected to liquid scintillation counting ...

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The relationship between the QRS transition zone of the standard 12-lead ECG and interventricular septum was studied. The position and the angle to the horizontal line of the interventricular septum were evaluated with computed tomography (CT) and compared to the QRS transition zone. The subjects were 36 patients with no cardiovascular diseases. The patients were divided into 3 groups according to the position of QRS transition zone: V{sub 1}-V{sub 2} (8 cases), V{sub 3}-V{sub 4} (21 cases), and V{sub 5}-V{sub 6} (7 cases). The interventricular septum on CT was directed to the anterior chest wall between V{sub 3} and V{sub 4} in all 3 groups. The mean value of the interventricular septal angle did not differ from group to group, 52.1deg for V{sub 1}-V{sub 2} group, 49.8deg for V{sub 3}-V{sub 4} group, and 48.2deg for V{sub 5}-V{sub 6}. It was concluded that the direction of the interventricular septum was not one of the major determinants of the QRS transition zone ...

International Nuclear Information System (INIS)

The contribution of platelets and clotting factors in thrombosis on cardiovascular prostheses had been quantified with several tracers. Thrombus formation in vivo could be measured semiquantitatively in animal models and patients with indium-111, Technetium-99m labeled platelets, iodine-123, iodine-131 labeled fibrinogen, and In-111 and Tc-99m labeled antibody to the fibrinogen-receptor on the platelet- membrane, or fibrin. The early studies demonstrated that certain platelet-inhibitors, e.g. sulfinpyrazone, aspirin or aspirin- persantine increased platelet survival time with mechanical valves implanted in the baboon model and patients. Thrombus localization by imaging is possible for large thrombus on thrombogenic surface of prosthesis in the acute phase. The majority of thrombus was found in the sewing ring (Dacron) in the acute phase in both the mechanical and tissue valves. The amount of retained thrombus in both mechanical and tissue valves in our one-day ...

Science.gov (United States)

A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are ...

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Electrographic R-R interval variation was examined in a total of 915 A-bomb survivors exposed at {<=}2,000 m from the hypocenter (the {<=} 2,000 m group) and a total of 1,162 A-bomb survivors exposed at >3,000 m or entered the city after the A-bombing (the >3,000 m group). Coefficient of variation (CV) for R-R interval variation on ECG tended to be decreased with advancing age in the >3,000 m group, irrespective of sex. Especially for men in this group, CV values were significantly lower for the age group of 45 to 54 years than the groups of 65 to 74 years and 75 to 84 years. Similar tendency was observed for CV values at deep breath. Decreased CV values tended to be associated with a decrease in glucose tolerance in both men and women of the >3,000 m group. In comparing the aforementioned CV values with those in the {<=}2,000 m group, there was no significant difference between the groups. R-R interval variation on ECG was found independent of exposure condition, ...

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This report is a survey of the English language literature of radiation biology between 1947 and 1987, for the purpose of compiling a literature base on the effects of radiation on animals, which have yielded results that can expand our knowledge about similar radiation effects on human beings. Articles were sought that reported exposure of adult mammals to external sources of ionizing radiation, having endpoints that included effects on the brain, the spinal cord, and behavior of the gastrointestinal, endocrine, and cardiovascular systems and the hematopoietic and immune systems. Effects of interest were those that occurred within the first 12 months after exposure. The survey does not include articles reporting chronic or long term delayed effects of radiation unless they provided insight into mechanisms of morphological and/or functional derangement. Information presented in the report is divided into subtopics (i.e., Brain-Morphological Changes). The brief ...

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