Volumetric Flow Measurement Using an Implantable CMUT Array.
Mengli Wang; Jingkuang Chen
2011-06-01
This paper describes volumetric-flow velocity measurement using an implantable capacitive micromachined ultrasonic transducer (CMUT) array. The array is comprised of multiple-concentric CMUT rings for ultrasound transmission and an outmost annular CMUT array for ultrasound reception. Microelectromechanical-system (MEMS) fabrication technology allows reception CMUT on this flowmeter to be implemented with a different membrane thickness and gap height than that of transmission CMUTs, optimizing the performance of these two different kinds of devices. The silicon substrate of this 2-mm-diameter CMUT ring array was bulk micromachined to approximately 80 to 100 μm thick, minimizing tissue disruption. The blood-flow velocity was detected using pulse ultrasound Doppler by comparing the demodulated echo ultrasound with the incident ultrasound. The demodulated ultrasound signal was sampled by a pulse delayed in time domain from the transmitted burst, which corresponds to detecting the signal at a specific distance. The flow tube/vessel diameter was detected through the time-flight delay difference from near and far wall reflections, which was measured from the ultrasound pulse echo. The angle between the ultrasound beam and the flow was found by using the cross-correlation from consecutive ultrasound echoes. Artificial blood flowing through three different polymer tubes was experimented with, while keeping the same volumetric flow rate. The discrepancy in flow measurement results between this CMUT meter and a calibrated laser Doppler flowmeter is less than 5%. PMID:23851472
A nonlinear lumped model for ultrasound systems using CMUT arrays.
Satir, Sarp; Degertekin, F Levent
2015-10-01
We present a nonlinear lumped model that predicts the electrical input-output behavior of an ultrasonic system using CMUTs with arbitrary array/membrane/electrode geometry in different transmit-receive configurations and drive signals. The receive-only operation, where the electrical output signal of the CMUT array in response to incident pressure field is calculated, is included by modifying the boundary elementbased vibroacoustic formulation for a CMUT array in rigid baffle. Along with the accurate large signal transmit model, this formulation covers pitch-catch and pulse-echo operation when transmit and receive signals can be separated in time. In cases when this separation is not valid, such as CMUTs used in continuous wave transmit-receive mode, pulse-echo mode with a nearby hard or soft wall or in a bounded space such as in a microfluidic channel, an efficient formulation based on the method of images is used. Some of these particular applications and the overall modeling approach have been validated through comparison with finite element analysis on specific examples including CMUTs with multiple electrodes. To further demonstrate the capability of the model for imaging applications, the two-way response of a partial dual-ring intravascular ultrasound array is simulated using a parallel computing cluster, where the output currents of individual array elements are calculated for given input pulse and compared with experimental results. With its versatility, the presented model can be a useful tool for rapid iterative CMUT-based system design and simulation for a broad range of ultrasonic applications. PMID:26470049
Row-Column Addressed 2-D CMUT Arrays with Integrated Apodization
Christiansen, Thomas Lehrmann; Rasmussen, Morten Fischer; Jensen, Jørgen Arendt;
2014-01-01
Experimental results from row-column addressed capacitive micromachined ultrasonic transducers (CMUTs) with integrated apodization are presented. The apodization is applied by varying the density of CMUT cells in the array with the objective of damping the edge waves originating from the element...... ends. Two row-column addressed 32+32 CMUT arrays are produced using a wafer-bonding technique, one with and one without integrated apodization. Hydrophone measurements of the emitted pressure field from the array with integrated apodization show a reduction in edge wave energy of 8.4 dB (85 %) compared...
2-D Row-Column CMUT Arrays with an Open-Grid Support Structure
Christiansen, Thomas Lehrmann; Dahl-Petersen, Christian; Jensen, Jørgen Arendt;
2013-01-01
Fabrication and characterization of 64 + 64 2-D row-column addressed CMUT arrays with 250 μm element pitch and 4.4 MHz center frequency in air incorporating a new design approach is presented. The arrays are comprised of two wafer bonded, structured silicon-on-insulator wafers featuring an opengrid...... support structure on top of the CMUT plates, omitting the need for through wafer vias. A 5 mask process is used to produce 2-D row-column addressed CMUT arrays with 74 nm vacuum gaps, single crystalline silicon plates with optional lithographically defined mass loads, 120 V pull-in voltage, and high...
Equivalent circuit-based analysis of CMUT cell dynamics in arrays.
Oguz, H K; Atalar, Abdullah; Köymen, Hayrettin
2013-05-01
Capacitive micromachined ultrasonic transducers (CMUTs) are usually composed of large arrays of closely packed cells. In this work, we use an equivalent circuit model to analyze CMUT arrays with multiple cells. We study the effects of mutual acoustic interactions through the immersion medium caused by the pressure field generated by each cell acting upon the others. To do this, all the cells in the array are coupled through a radiation impedance matrix at their acoustic terminals. An accurate approximation for the mutual radiation impedance is defined between two circular cells, which can be used in large arrays to reduce computational complexity. Hence, a performance analysis of CMUT arrays can be accurately done with a circuit simulator. By using the proposed model, one can very rapidly obtain the linear frequency and nonlinear transient responses of arrays with an arbitrary number of CMUT cells. We performed several finite element method (FEM) simulations for arrays with small numbers of cells and showed that the results are very similar to those obtained by the equivalent circuit model. PMID:23661137
Void-Free Direct Bonding of CMUT Arrays with Single Crystalline Plates and Pull- In Insulation
Christiansen, Thomas Lehrmann; Hansen, Ole; Dahl Johnsen, Mathias;
2013-01-01
alteration of the final structure and no additional fabrication steps compared to the double oxidation process. Two identical CMUT arrays with circular and square cavities having diameter/side lengths of 72 μm/65 μm and a 20 μm interdistance are fabricated with the two processes, demonstrating void-free...
A Low-noise front-end circuit for 2D cMUT arrays
Güler, Ülkühan; Guler, Ulkuhan; Bozkurt, Ayhan
2006-01-01
cMUT technology enables 2D array design with front-end electronic integration through flip-chip bonding or cMUT-on-CMOS process. The size of a 2D array element is constrained in both dimensions due to the aperture sampling criteria, and therefore should be less than or equal to the half of the wavelength in both dimensions. Considering large parasitic capacitances introduced by the interconnections, such small transducer elements necessitate integrated low noise frontends for achieving accept...
A 5 meter range non-planar CMUT array for Automotive Collision Avoidance
Hernandez Aguirre, Jonathan
A discretized hyperbolic paraboloid geometry capacitive micromachined ultrasonic transducer (CMUT) array has been designed and fabricated for automotive collision avoidance. The array is designed to operate at 40 kHz, beamwidth of 40° with a maximum sidelobe intensity of -10dB. An SOI based fabrication technology has been used for the 5x5 array with 5 sensing surfaces along each x and y axis and 7 elevation levels. An assembly and packaging technique has been developed to realize the non-planar geometry in a PGA-68 package. A highly accurate mathematical method has been presented for analytical characterization of capacitive micromachined ultrasonic transducers (CMUTs) built with square diaphragms. The method uses a new two-dimensional polynomial function to more accurately predict the deflection curve of a multilayer square diaphragm subject to both mechanical and electrostatic pressure and a new capacitance model that takes into account the contribution of the fringing field capacitances.
Underwater Imaging Using a 1 × 16 CMUT Linear Array
Rui Zhang; Wendong Zhang; Changde He; Yongmei Zhang; Jinlong Song; Chenyang Xue
2016-01-01
A 1 × 16 capacitive micro-machined ultrasonic transducer linear array was designed, fabricated, and tested for underwater imaging in the low frequency range. The linear array was fabricated using Si-SOI bonding techniques. Underwater transmission performance was tested in a water tank, and the array has a resonant frequency of 700 kHz, with pressure amplitude 182 dB ( μ Pa · m / V ) at 1 m. The −3 dB main beam width of the designed dense linear array is approximately 5 degrees. Synthetic aper...
Underwater Imaging Using a 1 × 16 CMUT Linear Array
Zhang, Rui; Zhang, Wendong; He, Changde; Zhang, Yongmei; Song, Jinlong; Xue, Chenyang
2016-01-01
A 1 × 16 capacitive micro-machined ultrasonic transducer linear array was designed, fabricated, and tested for underwater imaging in the low frequency range. The linear array was fabricated using Si-SOI bonding techniques. Underwater transmission performance was tested in a water tank, and the array has a resonant frequency of 700 kHz, with pressure amplitude 182 dB (μPa·m/V) at 1 m. The −3 dB main beam width of the designed dense linear array is approximately 5 degrees. Synthetic aperture focusing technique was applied to improve the resolution of reconstructed images, with promising results. Thus, the proposed array was shown to be suitable for underwater imaging applications. PMID:26938536
Underwater Imaging Using a 1 × 16 CMUT Linear Array.
Zhang, Rui; Zhang, Wendong; He, Changde; Zhang, Yongmei; Song, Jinlong; Xue, Chenyang
2016-01-01
A 1 × 16 capacitive micro-machined ultrasonic transducer linear array was designed, fabricated, and tested for underwater imaging in the low frequency range. The linear array was fabricated using Si-SOI bonding techniques. Underwater transmission performance was tested in a water tank, and the array has a resonant frequency of 700 kHz, with pressure amplitude 182 dB (μPa·m/V) at 1 m. The -3 dB main beam width of the designed dense linear array is approximately 5 degrees. Synthetic aperture focusing technique was applied to improve the resolution of reconstructed images, with promising results. Thus, the proposed array was shown to be suitable for underwater imaging applications. PMID:26938536
3-D Vector Flow Using a Row-Column Addressed CMUT Array
Holbek, Simon; Christiansen, Thomas Lehrmann; Engholm, Mathias;
2016-01-01
cells, and second, elements areaccessed by row and/or column indices. The 62+62 2-D row-column addressed prototype CMUT probe was usedfor vector flow estimation by transmitting focused ultrasound into a flow-rig with a fully developed parabolicflow. The beam-to-flow angle was 90◦. The received data was...... characteristic parabolic velocity profile was estimated with a peak velocity of 0.48m/s ± 0.02 m/s in reference to the expected 0.54 m/s. The results presented are the first 3-D vector flow estimates obtained with a row-column CMUT probe, which demonstrates that the CMUT technology is feasiblefor 3-D flow...
Thermal-mechanical-noise-based CMUT characterization and sensing.
Gurun, Gokce; Hochman, Michael; Hasler, Paul; Degertekin, F Levent
2012-06-01
When capacitive micromachined ultrasonic transducers (CMUTs) are monolithically integrated with custom-designed low-noise electronics, the output noise of the system can be dominated by the CMUT thermal-mechanical noise both in air and in immersion even for devices with low capacitance. Because the thermal-mechanical noise can be related to the electrical admittance of the CMUTs, this provides an effective means of device characterization. This approach yields a novel method to test the functionality and uniformity of CMUT arrays and the integrated electronics when a direct connection to CMUT array element terminals is not available. Because these measurements can be performed in air at the wafer level, the approach is suitable for batch manufacturing and testing. We demonstrate this method on the elements of an 800-μm-diameter CMUT-on-CMOS array designed for intravascular imaging in the 10 to 20 MHz range. Noise measurements in air show the expected resonance behavior and spring softening effects. Noise measurements in immersion for the same array provide useful information on both the acoustic cross talk and radiation properties of the CMUT array elements. The good agreement between a CMUT model based on finite difference and boundary element methods and the noise measurements validates the model and indicates that the output noise is indeed dominated by thermal-mechanical noise. The measurement method can be exploited to implement CMUT-based passive sensors to measure immersion medium properties, or other parameters affecting the electro-mechanics of the CMUT structure. PMID:22718877
CMUT With Substrate-Embedded Springs For Non-Flexural Plate Movement.
Nikoozadeh, Amin; Khuri-Yakub, Pierre T
2010-01-01
A conventional capacitive micromachined ultrasonic transducer (CMUT) is composed of many cells connected in parallel. Since the plate in each CMUT cell is anchored at its perimeter, the average displacement is several times smaller than the displacement of an equivalent ideal piston transducer. In addition, the post areas, where the plates are anchored to, are non-active and, thus, do not contribute to the transduction. We propose a CMUT structure that resembles an ideal capacitive piston transducer, where the movable top plate only undergoes translation rather than deflection. Our proposed CMUT structure is composed of a rigid plate connected to a substrate using relatively long and narrow posts, providing the spring constant for the movement of the plate. Rather than the flexure of the plate as in a conventional CMUT, this device operates based on the compression of the compliant posts. For a capacitive transducer, a thin electrostatic gap is provided under the top plate. We used finite element analysis (FEA) to design and verify the structure's functionality. The simulation results show a fractional bandwidth of over 100% in immersion for all the designs. They also confirm that the average displacement of the top plate is above 90% of its peak displacement. We fabricated the first prototype based on this idea, which only requires a simple 3-mask fabrication process. In addition to 128-element 1-D arrays, we fabricated a variety of 240 μm × 240 μm, single-element transducers with different post configurations. We successfully measured the electrical input impedance of the fabricated devices and confirmed their resonant behavior in air. Further, we measured the acoustic pressure using a calibrated hydrophone at a known distance. Using this measurement, we calculated a peak-to-peak pressure of 1.5 MPa at the face of the transducer. Our results show that it is possible to fabricate CMUTs that exhibit ideal piston-like plate movement. Because of the substrate
Developing 1D nanostructure arrays for future nanophotonics
Cooke DG
2006-01-01
Full Text Available AbstractThere is intense and growing interest in one-dimensional (1-D nanostructures from the perspective of their synthesis and unique properties, especially with respect to their excellent optical response and an ability to form heterostructures. This review discusses alternative approaches to preparation and organization of such structures, and their potential properties. In particular, molecular-scale printing is highlighted as a method for creating organized pre-cursor structure for locating nanowires, as well as vapor–liquid–solid (VLS templated growth using nano-channel alumina (NCA, and deposition of 1-D structures with glancing angle deposition (GLAD. As regards novel optical properties, we discuss as an example, finite size photonic crystal cavity structures formed from such nanostructure arrays possessing highQand small mode volume, and being ideal for developing future nanolasers.
From nonfinite to finite 1D arrays of origami tiles.
Wu, Tsai Chin; Rahman, Masudur; Norton, Michael L
2014-06-17
average solution structures for blocks is more readily achieved using computer models than using direct imaging methods. The development of scalable 1D-origami arrays composed of uniquely addressable components is a logical, if not necessary, step in the evolution of higher order fully addressable structures. Our research into the fabrication of arrays has led us to generate a listing of several important areas of future endeavor. Of high importance is the re-enforcement of the mechanical properties of the building blocks and the organization of multiple arrays on a surface of technological importance. While addressing this short list of barriers to progress will prove challenging, coherent development along each of these lines of inquiry will accelerate the appearance of commercial scale molecular manufacturing. PMID:24803094
Progress in Development of HIFU CMUTs for use under MR-guidance
High intensity focused ultrasound (HIFU) guided by magnetic resonance imaging (MRI) is a noninvasive treatment that potentially reduces patient morbidity, lowers costs, and increases treatment accessibility. Traditionally, piezoelectric transducers are used for HIFU, but capacitive micromachined ultrasonic transducers (CMUTs) have many advantages, including fabrication flexibility, low loss, and efficient transmission. We designed, fabricated, and tested HIFU CMUTs for use under MRI guidance and have demonstrated continuous wave (CW) focusing. In this paper, we demonstrate that CMUTs can be designed for therapeutic ultrasound. First, we demonstrate successful unfocused heating of a HIFU phantom to 18.6 deg. C, which was successfully monitored under MR guidance. Second, we demonstrated a focused CMUT array whose beam profile matched with simulation. In the future, we will expand the array and system for upper abdominal cancer therapy.
Cooperative eigenmodes and scattering in 1D atomic arrays
Bettles, R J; Adams, C S
2016-01-01
Using a classical coupled dipole model, we numerically investigate the cooperative behavior of a one dimensional array of atomic dipoles driven by a weak laser field. Changing the polarization and direction of the driving field allows us to separately address superradiant, subradiant, red shifted, and blue shifted eigenmodes, as well as observe strong Fano-like interferences between different modes. The cooperative eigenvectors can be characterized by the phase difference between nearest neighbor dipoles, ranging from all oscillating in phase to all oscillating out of phase with their nearest neighbors. Investigating the eigenvalue behavior as a function of atom number and lattice spacing, we find that certain eigenmodes of an infinite atomic chain have the same decay rate as a single atom between two mirrors.
Simulating Capacitive Micromachined Ultrasonic Transducers (CMUTs) using Field II
Bæk, David; Oralkan, Omer; Kupnik, Mario;
2010-01-01
Field II has been a recognized simulation tool for piezoceramic medical transducer arrays for more than a decade. The program has its strength in doing fast computations of the spatial impulse response (SIR) from array elements by dividing the elements into smaller mathematical elements (ME)s from...... which it calculates the SIR responses. The program features predefined models for classical transducer geometries, but currently none for the fast advancing CMUTs. This work addresses the assumptions required for modeling CMUTs with Field II. It is shown that rectangular array elements, populated with...... cells, can be well approximated by neglecting the cells. Further, it is demonstrated that scaling of the SIR translates into better computational efficiency....
Glucose sensor using periodic nanostructured hybrid 1D Au/ZnO arrays
Huh, Pil Ho, E-mail: pilho.huh@samsung.com [Samsung Electronics Co., Ltd. Nongseo-Dong, Giheung-Gu, Yongin-City, Gyeonggi-Do 446-711 (Korea, Republic of); Kim, Myunghwan [Samsung Electronics Co., Ltd. Nongseo-Dong, Giheung-Gu, Yongin-City, Gyeonggi-Do 446-711 (Korea, Republic of); Kim, Seong-Cheol, E-mail: sckim07@ynu.ac.kr [School of Textiles, Yeungnam University, Gyeungsan Gyeungbuk 712-749 (Korea, Republic of)
2012-07-01
Hybrid 1D nanostructured Au/ZnO arrays were created by heat treatment of a spin-coated zinc acetate-PVA-Au(III) layer on surface relief grating and functioned as an electrochemical and optical D(+)-glucose sensor due to electrochemical oxidation between hybrid nanostructures and D(+)-glucose. The morphology and chemical composition of 1D Au/ZnO hybrid arrays were characterized by means of AFM, SEM, EDAX, and XPS. Electrochemical and optical sensitivities by the addition of D(+)-glucoses on 1D Au/ZnO arrays were investigated using Cyclic voltammetry and UV-vis-NIR spectra in the medical concentration ranges of 0.5, 2.0, and 8.0 mM. - Highlights: Black-Right-Pointing-Pointer Zinc acetate-PVA-Au(III) composites were prepared by simply mixing zinc acetate-PVA and gold(III) chloride trihydrate. Black-Right-Pointing-Pointer Hybrid 1D nanostructured Au/ZnO arrays were easily fabricated using surface relief gratings without additional process steps. Black-Right-Pointing-Pointer Redox and optical sensor to detect D(+)-glucoses.
Glucose sensor using periodic nanostructured hybrid 1D Au/ZnO arrays
Hybrid 1D nanostructured Au/ZnO arrays were created by heat treatment of a spin-coated zinc acetate-PVA-Au(III) layer on surface relief grating and functioned as an electrochemical and optical D(+)-glucose sensor due to electrochemical oxidation between hybrid nanostructures and D(+)-glucose. The morphology and chemical composition of 1D Au/ZnO hybrid arrays were characterized by means of AFM, SEM, EDAX, and XPS. Electrochemical and optical sensitivities by the addition of D(+)-glucoses on 1D Au/ZnO arrays were investigated using Cyclic voltammetry and UV–vis-NIR spectra in the medical concentration ranges of 0.5, 2.0, and 8.0 mM. - Highlights: ► Zinc acetate-PVA-Au(III) composites were prepared by simply mixing zinc acetate-PVA and gold(III) chloride trihydrate. ► Hybrid 1D nanostructured Au/ZnO arrays were easily fabricated using surface relief gratings without additional process steps. ► Redox and optical sensor to detect D(+)-glucoses.
A hand-held row-column addressed CMUT probe with integrated electronics for volumetric imaging
Engholm, Mathias; Christiansen, Thomas Lehrmann; Beers, Christopher;
2015-01-01
A 3 MHz, λ / 2-pitch 62+62 channel row-column addressed 2-D CMUT array designed to be mounted in a probe handle and connected to a commercial BK Medical scanner for real-time volumetric imaging is presented. It is mounted and wire-bonded on a flexible PCB, which is connected to two rigid PCBs with...
Dimensional Scaling for Optimized CMUT Operations
Lei, Anders; Diederichsen, Søren Elmin; la Cour, Mette Funding;
2014-01-01
This work presents a dimensional scaling study using numerical simulations, where gap height and plate thickness of a CMUT cell is varied, while the lateral plate dimension is adjusted to maintain a constant transmit immersion center frequency of 5 MHz. Two cell configurations have been simulated...
Acoustic backscatter and effective scatterer size estimates using a 2D CMUT transducer
Liu, W.; Zagzebski, J A; Hall, T.J.; Madsen, E L; Varghese, T.; Kliewer, M.A.; Panda, S.; Lowery, C; Barnes, S.
2008-01-01
Compared to conventional piezoelectric transducers, new capacitive microfabricated ultrasonic transducer (CMUT) technology is expected to offer a broader bandwidth, higher resolution and advanced 3D/4D imaging inherent in a 2D array. For ultrasound scatterer size imaging, a broader frequency range provides more information on frequency-dependent backscatter, and therefore, generally more accurate size estimates. Elevational compounding, which can significantly reduce the large statistical flu...
Integrated Reconfigurable High-Voltage Transmitting Circuit for CMUTs
Llimos Muntal, Pere; Larsen, Dennis Øland; Jørgensen, Ivan Harald Holger; Bruun, Erik
2014-01-01
In this paper a full high-voltage transmitting cir- cuit aimed for capacitive micromachined ultrasonic transducers (CMUTs) used in ultrasound medical applications is designed and implemented in a 0.35 μm high-voltage CMOS process. The CMUT is single-ended driven. The design is taped-out and...
Mutual Radiation Impedance of Uncollapsed CMUT Cells with Different Radii
Ozgurluk, Alper; Atalar, Abdullah; Koymen, Hayrettin
2015-01-01
A polynomial approximation is proposed for the mutual acoustic impedance between uncollapsed capacitive micromachined ultrasonic transducer (CMUT) cells with different radii in an infinite rigid baffle. The resulting approximation is employed in simulating CMUTs with a circuit model. A very good agreement is obtained with the corresponding finite element simulation (FEM) result.
Localized self-heating in large arrays of 1D nanostructures
Monereo, O.; Illera, S.; Varea, A.; Schmidt, M.; Sauerwald, T.; Schütze, A.; Cirera, A.; Prades, J. D.
2016-02-01
One dimensional (1D) nanostructures offer a promising path towards highly efficient heating and temperature control in integrated microsystems. The so called self-heating effect can be used to modulate the response of solid state gas sensor devices. In this work, efficient self-heating was found to occur at random networks of nanostructured systems with similar power requirements to highly ordered systems (e.g. individual nanowires, where their thermal efficiency was attributed to the small dimensions of the objects). Infrared thermography and Raman spectroscopy were used to map the temperature profiles of films based on random arrangements of carbon nanofibers during self-heating. Both the techniques demonstrate consistently that heating concentrates in small regions, the here-called ``hot-spots''. On correlating dynamic temperature mapping with electrical measurements, we also observed that these minute hot-spots rule the resistance values observed macroscopically. A physical model of a random network of 1D resistors helped us to explain this observation. The model shows that, for a given random arrangement of 1D nanowires, current spreading through the network ends up defining a set of spots that dominate both the electrical resistance and power dissipation. Such highly localized heating explains the high power savings observed in larger nanostructured systems. This understanding opens a path to design highly efficient self-heating systems, based on random or pseudo-random distributions of 1D nanostructures.One dimensional (1D) nanostructures offer a promising path towards highly efficient heating and temperature control in integrated microsystems. The so called self-heating effect can be used to modulate the response of solid state gas sensor devices. In this work, efficient self-heating was found to occur at random networks of nanostructured systems with similar power requirements to highly ordered systems (e.g. individual nanowires, where their thermal
Exact electron states in 1D (quasi-) periodic arrays of delta-potentials
Kramer, Peter; Kramer, Tobias
1999-01-01
Exact one-electron eigenstates in finite parts of 1D periodic and Fibonacci chains of attractive and repulsive delta potentials are computed and analyzed. Bloch and bound state boundary conditions are related in terms of transfer matrices. Scenarios of positive and negative energy are distinguished. The dependence on the potential strength parameter is analyzed. The scattering matrix is computed. Implications for the interpretation of band germs in quasiperiodic chains are discussed.
Inclusion of Cu nano-cluster 1D arrays inside a C3-symmetric artificial oligopeptide via co-assembly
Gong, Ruiying; Li, Fei; Yang, Chunpeng; Wan, Xiaobo
2015-12-01
A peptide sequence N3-GVGV-OMe (G: glycine; V: valine) was attached to a benzene 1,3,5-tricarboxamide (BTA) derivative via ``click chemistry'' to afford a C3-symmetric artificial oligopeptide. The key feature of this oligopeptide is that the binding sites (triazole groups formed by click reaction) are located at the center, while the three oligopeptide arms with a strong tendency to assemble are located around it, which provides inner space to accommodate nanoparticles via self-assembly. The inclusion of Cu nanoclusters and the formation of one-dimensional (1D) arrays inside the nanofibers of the C3-symmetric artificial oligopeptide assembly were observed, which is quite different from the commonly observed nanoparticle growth on the surface of the pre-assembled oligopeptide nanofibers via the coordination sites located outside. Our finding provides an instructive concept for the design of other stable organic-inorganic hybrid 1D arrays with the inorganic nanoparticles inside.A peptide sequence N3-GVGV-OMe (G: glycine; V: valine) was attached to a benzene 1,3,5-tricarboxamide (BTA) derivative via ``click chemistry'' to afford a C3-symmetric artificial oligopeptide. The key feature of this oligopeptide is that the binding sites (triazole groups formed by click reaction) are located at the center, while the three oligopeptide arms with a strong tendency to assemble are located around it, which provides inner space to accommodate nanoparticles via self-assembly. The inclusion of Cu nanoclusters and the formation of one-dimensional (1D) arrays inside the nanofibers of the C3-symmetric artificial oligopeptide assembly were observed, which is quite different from the commonly observed nanoparticle growth on the surface of the pre-assembled oligopeptide nanofibers via the coordination sites located outside. Our finding provides an instructive concept for the design of other stable organic-inorganic hybrid 1D arrays with the inorganic nanoparticles inside. Electronic
Electromagnetic Wave Propagation in a Quasi-1D Rhombic Linear Optical Waveguide Array
Maimistov, Andrey I
2016-01-01
The quasi-one-dimensional rhombic array of the waveguides is considered. System of equations describing coupled waves in the waveguide in the linear limit is solved exactly. The electric field distribution was found both for the diffractionless (or dispersionless) flat band modes and for the dispersive modes.
Dimensional phase transition from an array of 1D Luttinger liquids to a 3D Bose-Einstein condensate.
Vogler, Andreas; Labouvie, Ralf; Barontini, Giovanni; Eggert, Sebastian; Guarrera, Vera; Ott, Herwig
2014-11-21
We study the thermodynamic properties of a 2D array of coupled one-dimensional Bose gases. The system is realized with ultracold bosonic atoms loaded in the potential tubes of a two-dimensional optical lattice. For negligible coupling strength, each tube is an independent weakly interacting 1D Bose gas featuring Tomonaga Luttinger liquid behavior. By decreasing the lattice depth, we increase the coupling strength between the 1D gases and allow for the phase transition into a 3D condensate. We extract the phase diagram for such a system and compare our results with theoretical predictions. Because of the high effective mass across the periodic potential and the increased 1D interaction strength, the phase transition is shifted to large positive values of the chemical potential. Our results are prototypical to a variety of low-dimensional systems, where the coupling between the subsystems is realized in a higher spatial dimension such as coupled spin chains in magnetic insulators. PMID:25479499
Capacitive micromachined ultrasonic transducer arrays as tunable acoustic metamaterials.
Lani, Shane W; Wasequr Rashid, M; Hasler, Jennifer; Sabra, Karim G; Levent Degertekin, F
2014-02-01
Capacitive Micromachined Ultrasonic Transducers (CMUTs) operating in immersion support dispersive evanescent waves due to the subwavelength periodic structure of electrostatically actuated membranes in the array. Evanescent wave characteristics also depend on the membrane resonance which is modified by the externally applied bias voltage, offering a mechanism to tune the CMUT array as an acoustic metamaterial. The dispersion and tunability characteristics are examined using a computationally efficient, mutual radiation impedance based approach to model a finite-size array and realistic parameters of variation. The simulations are verified, and tunability is demonstrated by experiments on a linear CMUT array operating in 2-12 MHz range. PMID:24753623
Capacitive micromachined ultrasonic transducer arrays as tunable acoustic metamaterials
Capacitive Micromachined Ultrasonic Transducers (CMUTs) operating in immersion support dispersive evanescent waves due to the subwavelength periodic structure of electrostatically actuated membranes in the array. Evanescent wave characteristics also depend on the membrane resonance which is modified by the externally applied bias voltage, offering a mechanism to tune the CMUT array as an acoustic metamaterial. The dispersion and tunability characteristics are examined using a computationally efficient, mutual radiation impedance based approach to model a finite-size array and realistic parameters of variation. The simulations are verified, and tunability is demonstrated by experiments on a linear CMUT array operating in 2-12 MHz range
Capacitive micromachined ultrasonic transducer arrays as tunable acoustic metamaterials
Lani, Shane W., E-mail: shane.w.lani@gmail.com, E-mail: karim.sabra@me.gatech.edu, E-mail: levent.degertekin@me.gatech.edu; Sabra, Karim G. [George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801Ferst Drive, Georgia 30332-0405 (United States); Wasequr Rashid, M.; Hasler, Jennifer [School of Electrical and Computer Engineering, Georgia Institute of Technology, Van Leer Electrical Engineering Building, 777 Atlantic Drive NW, Atlanta, Georgia 30332-0250 (United States); Levent Degertekin, F. [George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801Ferst Drive, Georgia 30332-0405 (United States); School of Electrical and Computer Engineering, Georgia Institute of Technology, Van Leer Electrical Engineering Building, 777 Atlantic Drive NW, Atlanta, Georgia 30332-0250 (United States)
2014-02-03
Capacitive Micromachined Ultrasonic Transducers (CMUTs) operating in immersion support dispersive evanescent waves due to the subwavelength periodic structure of electrostatically actuated membranes in the array. Evanescent wave characteristics also depend on the membrane resonance which is modified by the externally applied bias voltage, offering a mechanism to tune the CMUT array as an acoustic metamaterial. The dispersion and tunability characteristics are examined using a computationally efficient, mutual radiation impedance based approach to model a finite-size array and realistic parameters of variation. The simulations are verified, and tunability is demonstrated by experiments on a linear CMUT array operating in 2-12 MHz range.
Ordered 1-D and 2-D InAs/InP quantum dot arrays at telecom wavelength
Lateral one-dimensional (1-D) and two-dimensional (2-D) InAs/InP quantum dot (QD) arrangements are created by the concept of self-organized anisotropic strain engineering of InAs/InGaAsP superlattice (SL) templates on InP (100) and (311)B substrates by chemical-beam epitaxy (CBE). The SL templates comprise several-periods of an InAs QD layer plus a thin cap layer, post-growth annealing, and a separation layer. QDs order on top of the templates due to local strain recognition. Distinct preferential In adatom surface migration during annealing and substrate miscut lead to linear QD arrays along [001] for InP (100) substrates and a periodic square lattice aligned ±450 off [-233] for InP (311)B substrates. Optimization of the growth parameters balances In desorption and leads to well-separated and highly uniform QD arrays. Importantly, strong photoluminescence (PL) of defect-free InAs QD arrays is observed with the wavelength tuned into the 1.55-μim telecom region at room temperature through the insertion of GaAs interlayer beneath the QDs. Finally, the concept of self-organized anisotropic strain engineering for QD ordering is extended for formation of more complex architectures by combining it with step-engineering on shallow- and deep-patterned substrates. On the sidewall areas, the steps generated by the artificial patterns play the major role in determination of the In adatom surface migration during annealing, altering the QD arrays direction away from [001] on stripe-patterned InP (100) substrates. On the contrary, the sidewalls on patterned InP (311)B are faceted, not affecting the orientation of the 2-D InAs QD arrays.
Singulation for imaging ring arrays of capacitive micromachined ultrasonic transducers
Singulation of MEMS is a critical step in the transition from wafer-level to die-level devices. As is the case for capacitive micromachined ultrasound transducer (CMUT) ring arrays, an ideal singulation must protect the fragile membranes from the processing environment while maintaining a ring array geometry. The singulation process presented in this paper involves bonding a trench-patterned CMUT wafer onto a support wafer, deep reactive ion etching (DRIE) of the trenches, separating the CMUT wafer from the support wafer and de-tethering the CMUT device from the CMUT wafer. The CMUT arrays fabricated and singulated in this process were ring-shaped arrays, with inner and outer diameters of 5 mm and 10 mm, respectively. The fabricated CMUT ring arrays demonstrate the ability of this method to successfully and safely singulate the ring arrays and is applicable to any arbitrary 2D shaped MEMS device with uspended microstructures, taking advantage of the inherent planar attributes of DRIE. (technical note)
Doh, Il; Kim, Yong Tae; Ahn, Bong Young [Center for Medical Metrology, Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Kim, Kwang Youn [Meta biomed Co.,Ltd, Cheongju (Korea, Republic of)
2015-04-15
This paper describes the construction of a static 3D ultrasonography image by tracking the radiation beam position during the handy operation of a 1D array probe to enable point-of-care use. The theoretical model of the transformation from the translational and rotational information of the sensor mounted on the probe to the reference Cartesian coordinate system was given. The signal amplification and serial communication interface module was made using a commercially available sensor. A test phantom was also made using silicone putty in a donut shape. During the movement of the hand-held probe, B-mode movie and sensor signals were recorded. B-mode images were periodically selected from the movie, and the gray levels of the pixels for each image were converted to the gray levels of 3D voxels. 3D and 2D images of arbitrary cross-section of the B-mode type were also constructed from the voxel data, and agreed well with the shape of the test phantom.
Integrated differential high-voltage transmitting circuit for CMUTs
Llimos Muntal, Pere; Larsen, Dennis Øland; Farch, Kjartan;
2015-01-01
In this paper an integrated differential high-voltage transmitting circuit for capacitive micromachined ultrasonic transducers (CMUTs) used in portable ultrasound scanners is designed and implemented in a 0.35 μm high-voltage process. Measurements are performed on the integrated circuit in order...... to assess its performance. The circuit generates pulses at differential voltage levels of 60V, 80V and 100 V, a frequency up to 5MHz and a measured driving strength of 1.75 V/ns with the CMUT connected. The total on-chip area occupied by the transmitting circuit is 0.18 mm2 and the power consumption...
Integrated reconfigurable high-voltage transmitting circuit for CMUTs
Llimos Muntal, Pere; Larsen, Dennis Øland; Jørgensen, Ivan Harald Holger;
2015-01-01
In this paper a high-voltage transmitting circuit aimed for capacitive micromachined ultrasonic transducers (CMUTs) used in scanners for medical applications is designed and implemented in a 0.35 μm high-voltage CMOS process. The transmitting circuit is reconfigurable externally making it able...... to drive a wide variety of CMUTs. The transmitting circuit can generate several pulse shapes with voltages up to 100 V, maximum pulse range of 50 V, frequencies up to 5 MHz and different driving slew rates. Measurements are performed on the circuit in order to assess its functionality and power consumption...
Capacitive micromachined ultrasonic transducer arrays as tunable acoustic metamaterials
Lani, Shane W.; Wasequr Rashid, M.; Hasler, Jennifer; Sabra, Karim G.; Levent Degertekin, F.
2014-01-01
Capacitive Micromachined Ultrasonic Transducers (CMUTs) operating in immersion support dispersive evanescent waves due to the subwavelength periodic structure of electrostatically actuated membranes in the array. Evanescent wave characteristics also depend on the membrane resonance which is modified by the externally applied bias voltage, offering a mechanism to tune the CMUT array as an acoustic metamaterial. The dispersion and tunability characteristics are examined using a computationally ...
Investigation of PDMS as coating on CMUTs for Imaging
la Cour, Mette Funding; Stuart, Matthias Bo; Laursen, Mads Bjerregaard;
2014-01-01
A protective layer is necessary for Capacitive Mi- cromachined Ultrasonic Transducers (CMUTs) to be used for imaging purpose. The layer should both protect the device itself and the patient while maintaining the performance of the device. In this work Sylgard 170 PDMS is tested as coating material...
Modeling and Measurements of CMUTs with Square Anisotropic Plates
la Cour, Mette Funding; Christiansen, Thomas Lehrmann; Dahl-Petersen, Christian;
2013-01-01
The conventional method of modeling CMUTs use the isotropic plate equation to calculate the deflection, leading to deviations from FEM simulations including anisotropic effects of around 10% in center deflection. In this paper, the deflection is found for square plates using the full anisotropic ...
Abd Rahman Mohd Yusri
2011-01-01
Full Text Available Abstract A simple method for the synthesis of ZnO nanofilms composed of vertical array of quasi-1D ZnO nanostructures (quasi-NRs on the surface was demonstrated via a 1D crystal growth of the attached nanoseeds under a rapid hydrolysis process of zinc salts in the presence of ammonia at room temperature. In a typical procedure, by simply controlling the concentration of zinc acetate and ammonia in the reaction, a high density of vertically oriented nanorod-like morphology could be successfully obtained in a relatively short growth period (approximately 4 to 5 min and at a room-temperature process. The average diameter and the length of the nanostructures are approximately 30 and 110 nm, respectively. The as-prepared quasi-NRs products were pure ZnO phase in nature without the presence of any zinc complexes as confirmed by the XRD characterisation. Room-temperature optical absorption spectroscopy exhibits the presence of two separate excitonic characters inferring that the as-prepared ZnO quasi-NRs are high-crystallinity properties in nature. The mechanism of growth for the ZnO quasi-NRs will be proposed. Due to their simplicity, the method should become a potential alternative for a rapid and cost-effective preparation of high-quality ZnO quasi-NRs nanofilms for use in photovoltaic or photocatalytics applications. PACS: 81.07.Bc; 81.16.-c; 81.07.Gf.
Output pressure and harmonic characteristics of a CMUT as function of bias and excitation voltage
Lei, Anders; Diederichsen, Søren Elmin; Hansen, Sebastian Molbech; Stuart, Matthias Bo; Bouzari, Hamed; Jensen, Jørgen Arendt; Thomsen, Erik Vilain
The large bandwidth makes CMUT based transducers interesting for both conventional and harmonic imaging. The inherent nonlinear behavior of the CMUT, however, poses an issue for harmonic imaging as it is difficult to dissociate the harmonics generated in the tissue from the harmonic content of the...
Yang, Daquan; Wang, Chuan; Ji, Yuefeng
2016-07-25
We propose a novel multiplexed ultra-compact high-sensitivity one-dimensional (1D) photonic crystal (PC) nanobeam cavity sensor array on a monolithic silicon chip, referred to as Parallel Integrated 1D PC Nanobeam Cavity Sensor Array (PI-1DPC-NCSA). The performance of the device is investigated numerically with three-dimensional finite-difference time-domain (3D-FDTD) technique. The PI-1DPC-NCSA consists of multiple parallel-connected channels of integrated 1D PC nanobeam cavities/waveguides with gap separations. On each channel, by connecting two additional 1D PC nanobeam bandstop filters (1DPC-NBFs) to a 1D PC nanobeam cavity sensor (1DPC-NCS) in series, a transmission spectrum with a single targeted resonance is achieved for the purpose of multiplexed sensing applications. While the other spurious resonances are filtered out by the stop-band of 1DPC-NBF, multiple 1DPC-NCSs at different resonances can be connected in parallel without spectrum overlap. Furthermore, in order for all 1DPC-NCSs to be integrated into microarrays and to be interrogated simultaneously with a single input/output port, all channels are then connected in parallel by using a 1 × n taper-type equal power splitter and a n × 1 S-type power combiner in the input port and output port, respectively (n is the channel number). The concept model of PI-1DPC-NCSA is displayed with a 3-parallel-channel 1DPC-NCSs array containing series-connected 1DPC-NBFs. The bulk refractive index sensitivities as high as 112.6nm/RIU, 121.7nm/RIU, and 148.5nm/RIU are obtained (RIU = Refractive Index Unit). In particular, the footprint of the 3-parallel-channel PI-1DPC-NCSA is 4.5μm × 50μm (width × length), decreased by more than three orders of magnitude compared to 2D PC integrated sensor arrays. Thus, this is a promising platform for realizing ultra-compact lab-on-a-chip applications with high integration density and high parallel-multiplexing capabilities. PMID:27464080
Wang, Zhe
2010-10-01
We report superconducting resistive transition characteristics for array(s) of coupled 4-Angstrom single wall carbon nanotubes embedded in aluminophosphate-five zeolite. The transition was observed to initiate at 15 K with a slow resistance decrease switching to a sharp, order of magnitude drop between 7.5 and 6.0 K with strong (anisotropic) magnetic field dependence. Both the sharp resistance drop and its attendant nonlinear IV characteristics are consistent with the manifestations of a Berezinskii-Kosterlitz-Thouless transition that establishes quasi long range order in the plane transverse to the c-axis of the nanotubes, leading to an inhomogeneous system comprising 3D superconducting regions connected by weak links. Global coherence is established at below 5 K with the appearance of a well-defined supercurrent gap/low resistance region at 2 K. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Nguyen Van Toan
2016-04-01
Full Text Available This paper presents a process for the fabrication of vacuum-sealed capacitive micromachined ultrasonic transducer (CMUT arrays using glass reflow and anodic bonding techniques. Silicon through-wafer interconnects have been investigated by the glass reflow process. Then, the patterned silicon-glass reflow wafer is anodically bonded to an SOI (silicon-on-insulator wafer for the fabrication of CMUT devices. The CMUT 5 × 5 array has been successfully fabricated. The resonant frequency of the CMUT array with a one-cell radius of 100 µm and sensing gap of 3.2 µm (distance between top and bottom electrodes is observed at 2.84 MHz. The Q factor is approximately 1300 at pressure of 0.01 Pa.
Sato, M; Shi, W; Shige, S; Ishikawa, T; Soga, Y; Hubbard, B E; Ilic, B; Sievers, A J
2014-01-01
Both low frequency and high frequency impurity modes have been produced in a SiN micromechanical cantilever array by illumination with either an infrared or visible laser. When such laser-induced impurities are placed near a driven intrinsic localized mode (ILM) it is either repelled or attracted. By measuring the linear response spectrum for these two cases it was found that vibrational hopping of the ILM takes place when the natural frequency of the ILM and an even symmetry linear local mode are symmetrically located about the driven ILM frequency so that parametric excitation of these two linear modes is enhanced, amplifying the lateral motion of the ILM. Numerical simulations are consistent with these signature findings. It is also demonstrated that the correct sign of the observed interaction can be found with a harmonic lattice-impurity model but the magnitude of the effect is enhanced in a nonlinear lattice.
Modeling and Measuring the Effects of Mutual Impedance on Multi-Cell CMUT Configurations
Park, K. K.; Kupnik, M.; Lee, H. J.; Khuri-Yakub, B. T.; Wygant, I. O.
2010-01-01
This paper presents a numerical method for calculating the frequency response of a CMUT with a large number of cells. In a multi-cell configuration, commonly found in CMUTs, each cell is affected by the acoustic loading from neighboring cells. Thus, for an accurate model of a multi-cell CMUT element it is better to consider the mutual acoustic impedance instead of the acoustic impedance of a single cell only. We calculate the velocity of every cell (plate movement) simultaneously, with the mu...
Parametric nonlinear lumped element model for circular CMUTs in collapsed mode.
Aydoğdu, Elif; Ozgurluk, Alper; Atalar, Abdullah; Köymen, Hayrettin
2014-01-01
We present a parametric equivalent circuit model for a circular CMUT in collapsed mode. First, we calculate the collapsed membrane deflection, utilizing the exact electrical force distribution in the analytical formulation of membrane deflection. Then we develop a lumped element model of collapsed membrane operation. The radiation impedance for collapsed mode is also included in the model. The model is merged with the uncollapsed mode model to obtain a simulation tool that handles all CMUT behavior, in transmit or receive. Large- and small-signal operation of a single CMUT can be fully simulated for any excitation regime. The results are in good agreement with FEM simulations. PMID:24402904
Luo, Xi-Wang; Li, Chuan-Feng; Xu, Jin-Shi; Guo, Guang-Can; Zhou, Zheng-Wei
2015-01-01
Orbital angular momentum (OAM) of light is a fundamental optical degree of freedom that has recently motivated much exciting research in diverse fields ranging from optical communication to quantum information. We show for the first time that it is also a unique and valuable resource for quantum simulation, by demonstrating theoretically how \\emph{2d} topological physics can be simulated in a \\emph{1d} array of optical cavities using OAM-carrying photons. Remarkably, this newly discovered application of OAM states not only reduces required physical resources but also increases feasible scale of simulation. By showing how important topics such as edge-state transport and topological phase transition can be studied in a small simulator with just a few cavities ready for immediate experimental exploration, we demonstrate the prospect of photonic OAM for quantum simulation which can have a significant impact on the research of topological physics.
Electrostatic and Small-Signal Analysis of CMUTs With Circular and Square Anisotropic Plates
la Cour, Mette Funding; Christiansen, Thomas Lehrmann; Jensen, Jørgen Arendt;
2015-01-01
Traditionally, Capacitive Micromachined Ultrasonic Transducers (CMUTs) are modeled using the isotropic plate equation and this leads to deviations between analytical calcu- lations and Finite Element Modeling (FEM). In this paper, the deflection is calculated for both circular and square plates...
CMUTs with High-K Atomic Layer Deposition Dielectric Material Insulation Layer
Xu, Toby; Tekes, Coskun; Degertekin, F. Levent
2014-01-01
Use of high-κ dielectric, atomic layer deposition (ALD) materials as an insulation layer material for capacitive micromachined ultrasonic transducers (CMUTs) is investigated. The effect of insulation layer material and thickness on CMUT performance is evaluated using a simple parallel plate model. The model shows that both high dielectric constant and the electrical breakdown strength are important for the dielectric material, and significant performance improvement can be achieved, especiall...
Air damping effect on the air-based CMUT operation
Cha, Bu-Sang; Kanashima, Takeshi; Lee, Seung-Mok; Okuyama, Masanori
2015-08-01
The vibration amplitude, damping ratio and viscous damping force in capacitive micromachinedultrasonic transducers (CMUTs) with a perforated membrane have been calculated theoretically and compared with the experimental data on its vibration behavior. The electrical bias of the DC and the AC voltages and the operation frequency conditions influence the damping effect because leads to variations in the gap height and the vibration velocity of the membrane. We propose a new estimation method to determine the damping ratio by the decay rate of the vibration amplitudes of the perforated membrane plate are measured using a laser vibrometer at each frequency, and the damping ratios were calculated from those results. The influences of the vibration frequency and the electrostatic force on the damping effect under the various operation conditions have been studied.
CMUTs with high-K atomic layer deposition dielectric material insulation layer.
Xu, Toby; Tekes, Coskun; Degertekin, F
2014-12-01
Use of high-κ dielectric, atomic layer deposition (ALD) materials as an insulation layer material for capacitive micromachined ultrasonic transducers (CMUTs) is investigated. The effect of insulation layer material and thickness on CMUT performance is evaluated using a simple parallel plate model. The model shows that both high dielectric constant and the electrical breakdown strength are important for the dielectric material, and significant performance improvement can be achieved, especially as the vacuum gap thickness is reduced. In particular, ALD hafnium oxide (HfO2) is evaluated and used as an improvement over plasma-enhanced chemical vapor deposition (PECVD) silicon nitride (Six)Ny)) for CMUTs fabricated by a low-temperature, complementary metal oxide semiconductor transistor-compatible, sacrificial release method. Relevant properties of ALD HfO2) such as dielectric constant and breakdown strength are characterized to further guide CMUT design. Experiments are performed on parallel fabricated test CMUTs with 50-nm gap and 16.5-MHz center frequency to measure and compare pressure output and receive sensitivity for 200-nm PECVD Six)Ny) and 100-nm HfO2) insulation layers. Results for this particular design show a 6-dB improvement in receiver output with the collapse voltage reduced by one-half; while in transmit mode, half the input voltage is needed to achieve the same maximum output pressure. PMID:25474786
Feasibility of MR-temperature mapping of ultrasonic heating from a CMUT.
Wong, Serena H; Watkins, Ronald D; Kupnik, Mario; Pauly, Kim Butts; Khuri-Yakub, Butrus T
2008-04-01
In the last decade, high intensity focused ultrasound (HIFU) has gained popularity as a minimally invasive and noninvasive therapeutic tool for treatment of cancers, arrhythmias, and other medical conditions. HIFU therapy is often guided by magnetic resonance imaging (MRI), which provides anatomical images for therapeutic device placement, temperature maps for treatment guidance, and postoperative evaluation of the region of interest. While piezoelectric transducers are dominantly used for MR-guided HIFU, capacitive micromachined ultrasonic transducers (CMUTs) show competitive advantages, such as ease of fabrication, integration with electronics, improved efficiency, and reduction of self-heating. In this paper, we will show our first results of an unfocused CMUT transducer monitored by MR-temperature maps. This 2.51 mm by 2.32 mm, unfocused CMUT heated a HIFU phantom by 14 degrees C in 2.5 min. This temperature rise was successfully monitored by MR thermometry in a 3.0 T General Electric scanner. PMID:18467225
PECVD low stress silicon nitride analysis and optimization for the fabrication of CMUT devices
Two technological options to achieve a high deposition rate, low stress plasma-enhanced chemical vapor deposition (PECVD) silicon nitride to be used in capacitive micromachined ultrasonic transducers (CMUT) fabrication are investigated and presented. Both options are developed and implemented on standard production line PECVD equipment in the framework of a CMUT technology transfer from R and D to production. A tradeoff between deposition rate, residual stress and electrical properties is showed. The first option consists in a double layer of silicon nitride with a relatively high deposition rate of ∼100 nm min−1 and low compressive residual stress, which is suitable for the fabrication of the thick nitride layer used as a mechanical support of the CMUTs. The second option involves the use of a mixed frequency low-stress silicon nitride with outstanding electrical insulation capability, providing improved mechanical and electrical integrity of the CMUT active layers. The behavior of the nitride is analyzed as a function of deposition parameters and subsequent annealing. The nitride layer characterization is reported in terms of interfaces density influence on residual stress, refractive index, deposition rate, and thickness variation both as deposited and after thermal treatment. A sweet spot for stress stability is identified at an interfaces density of 0.1 nm−1, yielding 87 MPa residual stress after annealing. A complete CMUT device fabrication is reported using the optimized nitrides. The CMUT performance is tested, demonstrating full functionality in ultrasound imaging applications and an overall performance improvement with respect to previous devices fabricated with non-optimized silicon nitride. (paper)
Integrated Differential Three-Level High-Voltage Pulser Output Stage for CMUTs
Llimos Muntal, Pere; Larsen, Dennis Øland; Jørgensen, Ivan Harald Holger;
2015-01-01
A new integrated differential three-level highvoltage pulser output stage to drive capacitive micromachined ultrasonic transducers (CMUTs) is proposed in this paper. A topology comparison between the new differential output stage and the most commonly used single-ended topology is performed...... levels of 60, 80, 100V using 0.039mm2 of chip area. The power consumption is 0.951mW for a 30 pF CMUT load. The design presented is implemented in a 0.35 μm high-voltage process....
Pull-In Analysis of the Flat Circular CMUT Cell Featuring Sealed Cavity
Wen Zhang
2015-01-01
Full Text Available Capacitive micromachined ultrasonic transducers (CMUTs are one of the appealing MEMS devices. Most studies treat CMUTs as rigid plates vibrating in open air, ignoring the mechanical boundary conditions for simplification and resulting in cumulative errors in coupled fields. This paper presents a new analytical model for the pull-in characteristics of the flat circular CMUT cell featuring sealed cavity. Utilizing the plate theory coupled with Boyle’s law, the paper establishes a strong relation between the pressures inside the sealed cavity and the pull-in characteristics for the first time. Not only did we point out that the existence of the pressure inside the sealed cavity cannot be omitted, but we also quantified the direct effect of the pressure ratios on the pull-in phenomenon. The pull-in voltages increase while the pull-in ratios decrease with the pressure ratios of the pressure inside the sealed cavity to the ambient pressure. The proposed calculation process delivers a good approximation of the pull-in voltages and displacements, which are consistent with COMSOL simulation results. Particularly, the percentage error of our calculation process is 6.986% for the worst case. Therefore, our proposed analytical model accurately and efficiently predicts the pull-in characteristics and this paper offers new perspectives and reference value in designing and modeling the CMUTs.
Acoustical cross-talk in row–column addressed 2-D transducer arrays for ultrasound imaging
Christiansen, Thomas Lehrmann; Jensen, Jørgen Arendt; Thomsen, Erik Vilain
2015-01-01
The acoustical cross-talk in row–column addressed 2-D transducer arrays for volumetric ultrasound imaging is investigated. Experimental results from a 2.7 MHz, λ/2-pitch capacitive micromachined ultrasonic transducer (CMUT) array with 62 rows and 62 columns are presented and analyzed in the...
Wong, Serena H.; Wygant, Ira O.; Yeh, David T.; Zhuang, Xuefeng; Bayram, Baris; Kupnik, Mario; Oralkan, Omer; Ergun, A. Sanli; Yaralioglu, Goksen G.; Khuri-Yakub, Butrus T.
2006-05-01
In recent years, medical procedures have become increasingly non-invasive. These include endoscopic procedures and intracardiac interventions (e.g., pulmonary vein isolation for treatment of atrial fibrillation and plaque ablation for treatment of arteriosclerosis). However, current tools suffer from poor visualization and difficult coordination of multiple therapeutic and imaging devices. Dual-mode (imaging and therapeutic) ultrasound arrays provide a solution to these challenges. A dual-mode transducer can provide focused, noncontact ultrasound suitable for therapy and can be used to provide high quality real-time images for navigation and monitoring of the procedure. In the last decade, capacitive micromachined ultrasonic transducers (CMUTs), have become an attractive option for ultrasonic imaging systems due to their fabrication flexibility, improved bandwidth, and integration with electronics. The CMUT's potential in therapeutic applications has also been demonstrated by surface output pressures as high as 1MPa peak to peak and continuous wave (CW) operation. This paper reviews existing interventional CMUT arrays, demonstrates the feasibility of CMUTs for high intensity focused ultrasound (HIFU), and presents a design for the next-generation CMUTs for integrated imaging and HIFU endoscopic catheters.
Electrostatic and Small-Signal Analysis of CMUTs With Circular and Square Anisotropic Plates.
Funding la Cour, Mette; Christiansen, Thomas Lehrmann; Jensen, Jørgen Arendt; Thomsen, Erik Vilain
2015-08-01
Traditionally, capacitive micromachined ultrasonic transducers (CMUTs) are modeled using the isotropic plate equation, and this leads to deviations between analytical calculations and finite element modeling (FEM). In this paper, the deflection is calculated for both circular and square plates using the full anisotropic plate equation. It is shown that the anisotropic calculations match excellently with FEM, whereas an isotropic approach causes up to 10% deviations in deflection. For circular plates, an exact solution can be found. For square plates using the Galerkin method, and utilizing the symmetry of the silicon crystal, a compact and accurate expression for the deflection can be obtained. The deviation from FEM in center deflection is multilayer plates is also applied to the CMUT. The deflection of a square plate was measured on fabricated CMUTs using a white light interferometer. Fitting the plate parameter for the anisotropic calculated deflection to the measurement, a deviation of 0.07% is seen. Electrostatic and small-signal dynamic analysis are performed using energy considerations including anisotropy. The stable position, effective spring constant, pullin distance, and pull-in voltage are found for both circular and square anisotropic plates, and the pressure dependence is included by comparison with the corresponding analysis for a parallel plate. Measurements on fabricated devices with both circular and square plates subjected to increasing bias voltage are performed, and it is observed that the models including anisotropic effects are within the uncertainty interval of the measurements. Finally, a lumped element small-signal model for both circular and square anisotropic plates is derived to describe the dynamics of the CMUT. PMID:26492637
Progresses in cMUT device fabrication using low temperature processes
Bahette, E.; Michaud, J. F.; Certon, D.; Gross, D.; Alquier, D.
2014-04-01
In this paper, we present an original fabrication process of capacitive micromachined ultrasonic transducers (cMUTs) using a low temperature method for high frequency medical imaging applications. The process, which is limited to 400 °C, is based on surface micromachining. The material choices are adapted in order to respect the thermal specifications allowing monolithic integration. Thus, we have found alternative methods to replace the usual high temperature steps in cMUT elaboration. In this way, a nickel silicide layer, presenting good physical and electrical characteristics, is used as a bottom electrode. The membrane, silicon nitride, is deposited using a 200 °C PECVD process. Then, a metallic layer is chosen as a sacrificial layer, in order to achieve the cavity. For that, nickel has been chosen due to its low roughness and its high etching selectivity during the excavation. After their fabrication, the transducers have been tested to verify their functionality and, thus, to validate this low temperature process. Device physical properties have been determined by electrical and optical measurement in air. We evaluated resonance frequency, collapse voltage and electromechanical coupling coefficient in accordance with the simulation. Eventually, low charging effects and low initial deflections can predict good long-term use and ageing of the cMUTs.
We witnessed an initial hyped period and enthusiasm on carbon nano tubes in the 1990s later went through a significant expansion into nano tubes of other materials (metal di chalcogenides, boron nitride, etc.) as well as various nano wires and nano rods. While much of the hype might have gone, the research on one-dimensional (1D) nano materials has matured as one of the most active research areas within the nano science and nano technology community, flourishing with ample, exciting, and new research opportunities. Just like any other research frontier, researchers working in the 1D nano materials field are constantly striving to develop new fundamental science as well as potential applications. It remains a common belief that versatility and tunability of 1D nano materials would challenge many new rising tasks coming from our resource and energy demanding modern society. The traditional semiconductor industry has produced so many devices and systems from transistors, sensors, lasers, and LEDs to more sophisticated solar panels, which are now part of our daily lives. By down sizing the core components or parts to 1D form, one might wonder how fundamentally the dimensionality and morphology would impact the device performance, this is, as always, requiring us to fully understand the structure-property relationship in 1D nano materials. It may be equally crucial in connecting discovery-driven fundamental science to market-driven technology industry concerning potentially relevant findings derived from these novel materials. The importance of a platform that allows active researchers in this field to present their new development in a timely and efficient manner is therefore self-evident. Following the success of two early special issues devoted to 1D nano materials, this is the third one in a row organized by the same group of guest editors, attesting that such a platform has been well received by the readers
One-Dimensional (1-D) Nanoscale Heterostructures
Guozhen SHEN; Di CHEN; Yoshio BANDO; Dmitri GOLBERG
2008-01-01
One-dimensional (1-D) nanostructures have been attracted much attention as a result of their exceptional properties, which are different from bulk materials. Among 1-D nanostructures, 1-D heterostructures with modulated compositions and interfaces have recently become of particular interest with respect to potential applications in nanoscale building blocks of future optoelectronic devices and systems. Many kinds of methods have been developed for the synthesis of 1-D nanoscale heterostructures. This article reviews the most recent development, with an emphasize on our own recent efforts, on 1-D nanoscale heterostructures, especially those synthesized from the vapor deposition methods, in which all the reactive precursors are mixed together in the reaction chamber. Three types of 1-D nanoscale heterostructures, defined from their morphologies characteristics, are discussed in detail, which include 1-D co-axial core-shell heterostructures, 1-D segmented heterostructures and hierarchical heterostructures. This article begins with a brief survey of various methods that have been developed for synthesizing 1-D nanoscale heterostructures and then mainly focuses on the synthesis, structures and properties of the above three types of nanoscale heterostructures. Finally, this review concludes with personal views towards the topic of 1-D nanoscale heterostructures.
1-D ELECTRO-OPTIC BEAM STEERING DEVICE
Wang, Wei-Chih; Tsui, Chi Leung
2011-01-01
In this paper, we present the design and fabrication of a 1D beam steering device based on planar electro-optic thermal-plastic prisms and a collimator lens array. With the elimination of moving parts, the proposed device is able to overcome the mechanical limitations of present scanning devices, such as fatigue and low operating frequency, while maintaining a small system footprint (~0.5mm×0.5mm). From experimental data, our prototype device is able to achieve a maximum deflection angle of 5...
Akhbari, Sina; Sammoura, Firas; Lin, Liwei
2016-03-01
Equivalent circuit models of large arrays of curved (spherical shape) and flat piezoelectric micromachined ultrasonic transducers (pMUTs) have been developed for complex pMUT arrays design and analysis. The exact solutions for circuit parameters in the electromechanical domain, such as mechanical admittance, input electrical impedance, and electromechanical transformer ratio, were analytically derived. By utilizing the array solution methods previously established for the thickness-mode piezoelectric devices and capacitive micromachined ultrasonic transducers (cMUTs), the single pMUT circuit model can be extended to models for array structures. The array model includes both the self- and mutual-acoustic radiation impedances of individual transducers in the acoustic medium. Volumetric displacement, induced piezoelectric current, and pressure field can be derived with respect to the input voltage matrix, material, and geometrical properties of each individual transducer and the array structure. As such, the analytical models presented here can be used as a guideline for analyses and design evaluations of large arrays of curved and flat pMUTs efficiently and can be further generalized to evaluate other pMUT architectures in the form of single devices or arrays. PMID:26863658
Social exploration of 1D games
Valente, Andrea; Marchetti, Emanuela
2013-01-01
In this paper the apparently meaningless concept of a 1 dimensional computer game is explored, via netnography. A small number of games was designed and implemented, in close contact with online communities of players and developers, providing evidence that 1 dimension is enough to produce intere...... interesting gameplay, to allow for level design and even to leave room for artistic considerations on 1D rendering. General techniques to re-design classic 2D games into 1D are also emerging from this exploration....
Epitaxial 1D electron transport layers for high-performance perovskite solar cells.
Han, Gill Sang; Chung, Hyun Suk; Kim, Dong Hoe; Kim, Byeong Jo; Lee, Jin-Wook; Park, Nam-Gyu; Cho, In Sun; Lee, Jung-Kun; Lee, Sangwook; Jung, Hyun Suk
2015-10-01
We demonstrate high-performance perovskite solar cells with excellent electron transport properties using a one-dimensional (1D) electron transport layer (ETL). The 1D array-based ETL is comprised of 1D SnO2 nanowires (NWs) array grown on a F:SnO2 transparent conducting oxide substrate and rutile TiO2 nanoshells epitaxially grown on the surface of the 1D SnO2 NWs. The optimized devices show more than 95% internal quantum yield at 750 nm, and a power conversion efficiency (PCE) of 14.2%. The high quantum yield is attributed to dramatically enhanced electron transport in the epitaxial TiO2 layer, compared to that in conventional nanoparticle-based mesoporous TiO2 (mp-TiO2) layers. In addition, the open space in the 1D array-based ETL increases the prevalence of uniform TiO2/perovskite junctions, leading to reproducible device performance with a high fill factor. This work offers a method to achieve reproducible, high-efficiency perovskite solar cells with high-speed electron transport. PMID:26324759
YORP torques with 1D thermal model
Breiter, Slawomir; Czekaj, Maria
2010-01-01
A numerical model of the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect for objects defined in terms of a triangular mesh is described. The algorithm requires that each surface triangle can be handled independently, which implies the use of a 1D thermal model. Insolation of each triangle is determined by an optimized ray-triangle intersection search. Surface temperature is modeled with a spectral approach; imposing a quasi-periodic solution we replace heat conduction equation by the Helmholtz equation. Nonlinear boundary conditions are handled by an iterative, FFT based solver. The results resolve the question of the YORP effect in rotation rate independence on conductivity within the nonlinear 1D thermal model regardless of the accuracy issues and homogeneity assumptions. A seasonal YORP effect in attitude is revealed for objects moving on elliptic orbits when a nonlinear thermal model is used.
1D ferrimagnetism in homometallic chains
Coronado Miralles, Eugenio; Gómez García, Carlos José; Borrás Almenar, Juan José
1990-01-01
The magnetic properties of the cobalt zigzag chain Co(bpy)(NCS)2 (bpy=2,2′‐bipyridine) are discussed on the basis of an Ising‐chain model that takes into account alternating Landé factors. It is emphasized, for the first time, that a homometallic chain containing only one type of site can give rise to a 1D ferrimagneticlike behavior. ,
ZnO 1-D nanostructures: Low temperature synthesis and characterizations
Apurba Dev; S Chaudhuri; B N Dev
2008-06-01
ZnO is one of the most important semiconductors having a wide variety of applications in photonic, field emission and sensing devices. In addition, it exhibits a wide variety of morphologies in the nano regime that can be grown by tuning the growth habit of the ZnO crystal. Among various nanostructures, oriented 1-D nanoforms are particularly important for applications such as UV laser, sensors, UV LED, field emission displays, piezoelectric nanogenerator etc. We have developed a soft chemical approach to fabricate well-aligned arrays of various 1-D nanoforms like nanonails, nanowires and nanorods. The microstructural and photoluminescence properties of all the structures were investigated and tuned by varying the synthesis parameters. Field emission study from the aligned nanorod arrays exhibited high current density and a low turn-on field. These arrays also exhibited very strong UV emission and week defect emission. These structures can be utilized to fabricate efficient UV LEDs.
1-D EQUILIBRIUM DISCRETE DIFFUSION MONTE CARLO
T. EVANS; ET AL
2000-08-01
We present a new hybrid Monte Carlo method for 1-D equilibrium diffusion problems in which the radiation field coexists with matter in local thermodynamic equilibrium. This method, the Equilibrium Discrete Diffusion Monte Carlo (EqDDMC) method, combines Monte Carlo particles with spatially discrete diffusion solutions. We verify the EqDDMC method with computational results from three slab problems. The EqDDMC method represents an incremental step toward applying this hybrid methodology to non-equilibrium diffusion, where it could be simultaneously coupled to Monte Carlo transport.
Diagnostics from a 1-D atmospheric column
Flatley, J.M.; Mace, G. [Pennsylvania State Univ., University Park, PA (United States)
1996-04-01
Various diagnostics were computed from an array of radiosondes during an intensive field operation arranged by the Atmospheric Radiation Measurement Program. The network data was centered around the site at Lamont, Oklahoma. The apparent heat source and apparent moisture sink were computed and compared to the kinematic vertical velocity for both real data and the mesoscale analysis and prediction system. Three different case studies of various weathe regimes were examined.
Williams, James P.; Martin, Keith D.; Thomas, Justin R.; Caro, Samuel
2010-01-01
The International Space Station (ISS) Solar Array Management (SAM) software toolset provides the capabilities necessary to operate a spacecraft with complex solar array constraints. It monitors spacecraft telemetry and provides interpretations of solar array constraint data in an intuitive manner. The toolset provides extensive situational awareness to ensure mission success by analyzing power generation needs, array motion constraints, and structural loading situations. The software suite consists of several components including samCS (constraint set selector), samShadyTimers (array shadowing timers), samWin (visualization GUI), samLock (array motion constraint computation), and samJet (attitude control system configuration selector). It provides high availability and uptime for extended and continuous mission support. It is able to support two-degrees-of-freedom (DOF) array positioning and supports up to ten simultaneous constraints with intuitive 1D and 2D decision support visualizations of constraint data. Display synchronization is enabled across a networked control center and multiple methods for constraint data interpolation are supported. Use of this software toolset increases flight safety, reduces mission support effort, optimizes solar array operation for achieving mission goals, and has run for weeks at a time without issues. The SAM toolset is currently used in ISS real-time mission operations.
One-Dimensional (1D) ZnS Nanomaterials and Nanostructures
Xiaosheng FANG; Lide ZHANG
2006-01-01
One-dimensional (1D) nanomaterials and nanostructures have received much attention due to their potential interest for understanding fundamental physical concepts and for applications in constructing nanoscale electric and optoelectronic devices. Zinc sulfide (ZnS) is an important semiconductor compound of Ⅱ-Ⅵ group,and the synthesis of 1D ZnS nanomaterials and nanostructures has been of growing interest owing to their promising application in nanoscale optoelectronic devices. This paper reviews the recent progress on 1D ZnS nanomaterials and nanostructures, including nanowires, nanowire arrays, nanorods, nanobelts or nanoribbons,nanocables, and hierarchical nanostructures etc. This article begins with a survey of various methods that have been developed for generating 1D nanomaterials and nanostructures, and then mainly focuses on structures,synthesis, characterization, formation mechanisms and optical property tuning, and luminescence mechanisms of 1D ZnS nanomaterials and nanostructures. Finally, this review concludes with personal views towards future research on 1D ZnS nanomaterials and nanostructures.
Analysis list: Nr1d2 [Chip-atlas[Archive
Full Text Available Nr1d2 Liver + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d2.1.tsv... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d2.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d2....10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Nr1d2.Liver.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Liver.gml ...
Metastable states and information propagation in a 1D array of locally-coupled bistable cells
Anantram, M. P.; Roychowdhury, Vwani P.
1998-01-01
We study the effect of metastable states on the relaxation process (and hence information propagation) in locally coupled and boundary-driven structures. We first give a general argument to show that metastable states are inevitable even in the simplest of structures, a wire. At finite temperatures, the relaxation mechanism is a thermally assisted random walk. The time required to reach the ground state and its life time are determined by the coupling parameters. These time scales are studied...
Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos
Popovic, Marta; Zaja, Roko [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia); Fent, Karl [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz (Switzerland); Swiss Federal Institute of Technology (ETH Zürich), Department of Environmental System Sciences, Institute of Biogeochemistry and Pollution Dynamics, CH-8092 Zürich (Switzerland); Smital, Tvrtko, E-mail: smital@irb.hr [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia)
2014-10-01
Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos
Finite element analysis of underwater capacitor micromachined ultrasonic transducers.
Roh, Yongrae; Khuri-Yakub, Butrus T
2002-03-01
A simple electro-mechanical equivalent circuit model is used to predict the behavior of capacitive micromachined ultrasonic transducers (cMUT). Most often, cMUTs are made in silicon and glass plates that are in the 0.5 mm to 1 mm range in thickness. The equivalent circuit model of the cMUT lacks important features such as coupling to the substrate and the ability to predict cross-talk between elements of an array of transducers. To overcome these deficiencies, a flnite element model of the cMUT is constructed using the commercial code ANSYS. Calculation results of the complex load impedance seen by single capacitor cells are presented, then followed by a calculation of the plane wave real load impedance seen by a parallel combination of many cells that are used to make a transducer. Cross-talk between 1-D array elements is found to be due to two main sources: coupling through a Stoneley wave propagating at the transducer-water interface and coupling through Lamb waves propagating in the substrate. To reduce the cross-talk level, the effect of structural variations of the substrate are investigated, which includes a change of its thickness and etched trenches or polymer walls between array elements. PMID:12322877
The Gain Properties of 1-D Active Photonic Crystal
无
2003-01-01
The terminology 'ID frequency'(w ID) is proposed after analyzing the 1D active photonic crystal based on the transfer matrix method. The relationship between wID and the structure parameters of the photonic crystal is investigated.
Popovic, Marta; Zaja, Roko; Fent, Karl; Smital, Tvrtko
2014-10-01
Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. PMID:25088042
TBC1D24 genotype–phenotype correlation
Balestrini, Simona; Milh, Mathieu; Castiglioni, Claudia; Lüthy, Kevin; Finelli, Mattea J.; Verstreken, Patrik; Cardon, Aaron; Stražišar, Barbara Gnidovec; Holder, J. Lloyd; Lesca, Gaetan; Mancardi, Maria M.; Poulat, Anne L.; Repetto, Gabriela M.; Banka, Siddharth; Bilo, Leonilda; Birkeland, Laura E.; Bosch, Friedrich; Brockmann, Knut; Cross, J. Helen; Doummar, Diane; Félix, Temis M.; Giuliano, Fabienne; Hori, Mutsuki; Hüning, Irina; Kayserili, Hulia; Kini, Usha; Lees, Melissa M.; Meenakshi, Girish; Mewasingh, Leena; Pagnamenta, Alistair T.; Peluso, Silvio; Mey, Antje; Rice, Gregory M.; Rosenfeld, Jill A.; Taylor, Jenny C.; Troester, Matthew M.; Stanley, Christine M.; Ville, Dorothee; Walkiewicz, Magdalena; Falace, Antonio; Fassio, Anna; Lemke, Johannes R.; Biskup, Saskia; Tardif, Jessica; Ajeawung, Norbert F.; Tolun, Aslihan; Corbett, Mark; Gecz, Jozef; Afawi, Zaid; Howell, Katherine B.; Oliver, Karen L.; Berkovic, Samuel F.; Scheffer, Ingrid E.; de Falco, Fabrizio A.; Oliver, Peter L.; Striano, Pasquale; Zara, Federico
2016-01-01
Objective: To evaluate the phenotypic spectrum associated with mutations in TBC1D24. Methods: We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported and 37 published patients. TBC1D24 mutations, identified through various sequencing methods, can be found online (http://lovd.nl/TBC1D24). Results: Forty-eight patients were included (28 men, 20 women, average age 21 years) from 30 independent families. Eighteen patients (38%) had myoclonic epilepsies. The other patients carried diagnoses of focal (25%), multifocal (2%), generalized (4%), and unclassified epilepsy (6%), and early-onset epileptic encephalopathy (25%). Most patients had drug-resistant epilepsy. We detail EEG, neuroimaging, developmental, and cognitive features, treatment responsiveness, and physical examination. In silico evaluation revealed 7 different highly conserved motifs, with the most common pathogenic mutation located in the first. Neuronal outgrowth assays showed that some TBC1D24 mutations, associated with the most severe TBC1D24-associated disorders, are not necessarily the most disruptive to this gene function. Conclusions: TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes. PMID:27281533
Supported plasma-made 1D heterostructures: perspectives and applications
Borras, Ana; Macias-Montero, Manuel; Romero-Gomez, Pablo; Gonzalez-Elipe, Agustin R
2011-01-01
Abstract Plasma related methods have been widely used in the fabrication of carbon nanotubes and nanofibres and semiconducting inorganic nanowires. A natural progression of the research in the field of 1D nanostructures is the synthesis of multicomponent nanowires and nanofibres. In this article we review the state of the art of the fabrication by plasma methods of 1D heterostructures including applications and perspectives. Furthermore, recent developments on the use of metal seeds (Ag, A...
1D photonic crystal sensor integrated in a microfluidic system
Nunes, Pedro; Mortensen, Asger; Kutter, Jörg Peter; Mogensen, Klaus Bo
2009-01-01
A refractive index sensor was designed as a 1D resonator incorporated in a microfluidic channel, where aqueous solutions were injected. A sensitivity of 480 nm/RIU and a minimum difference of Deltan = 0.002 were determined.......A refractive index sensor was designed as a 1D resonator incorporated in a microfluidic channel, where aqueous solutions were injected. A sensitivity of 480 nm/RIU and a minimum difference of Deltan = 0.002 were determined....
Unveiling the Role of CNTs on the Phase Formation of 1D Ferroelectrics
Mahajan, Amit
2015-05-21
Carbon nanotubes (CNTs) have the potential to act as templates or bottom electrodes for three dimension (3D) capacitor arrays, which utilise one dimension (1D) ferroelectric nanostructures to increase memory size and density. However, growing a ferroelectric on the surface of CNTs is non-trivial. Here, we demonstrate that multi-walled (MW) CNTs decrease the time and temperature for formation of lead zirconium titanate Pb(Zr1-xTix)O3 (PZT) by ~100 ºC commensurate with a decrease in activation energy from 68±15 kJ/mol to 27±2 kJ/mol. As a consequence, monophasic PZT was obtained at 575 ºC for MWCNTs/PZT whereas for pure PZT traces of pyrochlore were still present at 650 ºC, where PZT phase formed due to homogeneous nucleation. The piezoelectric nature of MWCNT/PZT synthesised at 500 ºC for 1 h was proved. Although further work is required to prove the concept of 3D capacitor arrays, our result suggests that it is feasible to utilise MWCNTs as templates/electrodes for the formation of 1D PZT nano ferroelectrics.
Tuning the 1D-self-assembly of dicyano-functionalized helicene building-blocks
Full text: Effective control of chirality in supramolecular systems is an important challenge towards the assembly of well-defined nano-architectures from the bottom-up. The chirality transfer from single molecules onto 3D- and 2D-crystals is well known, however chirality in case of the 1D-objects (wires) is largely unexplored. Here we present a study based on Scanning Tunnelling Microscopy (STM) and X-Ray Photoelectron Spectroscopy (XPS) measurements and Density Functional Theory (DFT) calculations to understand the formation of 1D conglomerates from enantiopure dicyano functionalized heptahelicene molecules of both chiralities at different, well defined single-crystal surfaces. We show that the main bonding motif can be switched by temperature, substrate or adatom stimuli. We discuss the key driving forces for the formation of well-ordered long-range arrays and the chirality transfer on the single molecule scale as well as onto the 1D conglomerate as a whole. In comparison of experiment and theory, we deepen the insight into the chirality transfer in competition between molecule-molecule and surface-molecule interactions. (author)
L(d1, d2,..., dt)-Number λ(Cn; d1, d2,...,dt) of Cycles
GAO Zhen Bin; ZHANG Xiao Dong
2009-01-01
An L(d1,d2,...,dt)-labeling of a graph G is a function f from its vertex set V(G) to the set {0, 1,..., k} for some positive integer k such that {f(x) - f(y)| ≥ di, if the distance between vertices x and y in G is equal to i for i = 1,2,...,t. The L(d1,d2,...,dt)-number λ(G;d1,d2,... ,dt) of G is the smallest integer number k such that G has an L(d1,d2,... ,dt)labeling with max{f(x)|x ∈ V(G)} = k. In this paper, we obtain the exact values for λ(Cn; 2, 2,1) and λ(Cn; 3, 2, 1), and present lower and upper bounds for λ(Cn; 2,..., 2,1,..., 1)
Resonant indirect exchange in 1D semiconductor nanostructures
We consider resonant indirect exchange interaction between magnetic centers in 1D nanostructures. The magnetic centers are assumed to be coupled to the 1D conducting channel by the quantum tunneling which can be of resonant character. The indirect exchange between the centers is mediated by the free carriers of the channel. The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. The former case is attributed to conventional semiconductor (InGaAs based to be concrete) nanowires or nanowhiskers, while the latter case is associated with carbon nanotubes with magnetic adatoms. We demonstrate that whenever the energy of a bound state at the magnetic center lies within the continuum energy spectra of the delocalized carriers in the channel the indirect exchange is strongly enhanced due to effective tunnel hybridization of the bound states with the continuum. - Highlights: • A resonant indirect exchange interaction between magnetic centers mediated by a 1D conducting channel is considered. • It is shown that the indirect exchange is strongly enhanced due to resonant tunnel coupling of a magnetic bound state with the delocalized states. • The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. • Pecularities of the indirect exchange mediated by a carbon nanotube has been investigated
Resonant indirect exchange in 1D semiconductor nanostructures
Rozhansky, I.V., E-mail: rozhansky@gmail.com [Ioffe Institute, Russian Academy of Sciences, St.Petersburg 194021 (Russian Federation); Lappeenranta University of Technology, P.O. Box 20, FI-53851 Lappeenranta (Finland); St. Petersburg State Polytechnic University, St. Petersburg 195251 (Russian Federation); Krainov, I.V.; Averkiev, N.S. [Ioffe Institute, Russian Academy of Sciences, St.Petersburg 194021 (Russian Federation); Lähderanta, E. [Lappeenranta University of Technology, P.O. Box 20, FI-53851 Lappeenranta (Finland)
2015-06-01
We consider resonant indirect exchange interaction between magnetic centers in 1D nanostructures. The magnetic centers are assumed to be coupled to the 1D conducting channel by the quantum tunneling which can be of resonant character. The indirect exchange between the centers is mediated by the free carriers of the channel. The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. The former case is attributed to conventional semiconductor (InGaAs based to be concrete) nanowires or nanowhiskers, while the latter case is associated with carbon nanotubes with magnetic adatoms. We demonstrate that whenever the energy of a bound state at the magnetic center lies within the continuum energy spectra of the delocalized carriers in the channel the indirect exchange is strongly enhanced due to effective tunnel hybridization of the bound states with the continuum. - Highlights: • A resonant indirect exchange interaction between magnetic centers mediated by a 1D conducting channel is considered. • It is shown that the indirect exchange is strongly enhanced due to resonant tunnel coupling of a magnetic bound state with the delocalized states. • The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. • Pecularities of the indirect exchange mediated by a carbon nanotube has been investigated.
Iris Feature Extraction Method Based on 1D Gabor Filter
XU Guang-zhu; MA Yi-de; ZHANG Zai-feng
2008-01-01
The normalized iris image was divided into eight sub-bands, and every column of each sub-band was averaged by rows to generate eight 1D iris signals. Then the even symmetry item of 1D Gabor filter was used to describe local characteristic blocks in 1D iris signals, and the results were quantified by their polarities to generate iris codes. In order to estimate the performance of the presented method, an iris recognition platform was produced and the Hamming distance between two iris codes was computed to measure the dissimilarity of them. The experimental results in CASIA v1 0 and Bath iris image databases show that the proposed iris feature extraction algorithm has a promising potential in iris recognition.
Nonreciprocity of edge modes in 1D magnonic crystal
Lisenkov, I., E-mail: ivan.lisenkov@phystech.edu [Kotelnikov Institute of Radio-engineering and Electronics of RAS, 11-7 Mokhovaya st., Moscow 125009 (Russian Federation); Department of Physics, Oakland University, 2200 N. Squirrel Rd., Rochester, MI 48309 (United States); Moscow Institute of Physics and Technology, 9 Instituskij per., Dolgoprudny, 141700, Moscow Region (Russian Federation); Kalyabin, D., E-mail: dmitry.kalyabin@phystech.edu [Kotelnikov Institute of Radio-engineering and Electronics of RAS, 11-7 Mokhovaya st., Moscow 125009 (Russian Federation); Moscow Institute of Physics and Technology, 9 Instituskij per., Dolgoprudny, 141700, Moscow Region (Russian Federation); Osokin, S. [Kotelnikov Institute of Radio-engineering and Electronics of RAS, 11-7 Mokhovaya st., Moscow 125009 (Russian Federation); Moscow Institute of Physics and Technology, 9 Instituskij per., Dolgoprudny, 141700, Moscow Region (Russian Federation); Klos, J.W.; Krawczyk, M. [Adam Mickiewicz University in Poznan, Umultowska 85, Poznan 61-614 (Poland); Nikitov, S., E-mail: nikitov@cplire.ru [Kotelnikov Institute of Radio-engineering and Electronics of RAS, 11-7 Mokhovaya st., Moscow 125009 (Russian Federation); Moscow Institute of Physics and Technology, 9 Instituskij per., Dolgoprudny, 141700, Moscow Region (Russian Federation); Saratov State University, 112 Bol' shaya Kazach' ya, Saratov 410012 (Russian Federation)
2015-03-15
Spin waves propagation in 1D magnonic crystals is investigated theoretically. Mathematical model based on plane wave expansion method is applied to different types of magnonic crystals, namely bi-component magnonic crystal with symmetric/asymmetric boundaries and ferromagnetic film with periodically corrugated top surface. It is shown that edge modes in magnonic crystals may exhibit nonreciprocal behaviour at much lower frequencies than in homogeneous films. - Highlights: • Magnetostatic surface spin waves in 1D magnonic crystals were studied theoretically. • Mathematical model is based on plane wave method. • Mathematical model was applied to different types of magnonic crystals. • Stop band formation and nonreciprocity were obtained.
Nonreciprocity of edge modes in 1D magnonic crystal
Spin waves propagation in 1D magnonic crystals is investigated theoretically. Mathematical model based on plane wave expansion method is applied to different types of magnonic crystals, namely bi-component magnonic crystal with symmetric/asymmetric boundaries and ferromagnetic film with periodically corrugated top surface. It is shown that edge modes in magnonic crystals may exhibit nonreciprocal behaviour at much lower frequencies than in homogeneous films. - Highlights: • Magnetostatic surface spin waves in 1D magnonic crystals were studied theoretically. • Mathematical model is based on plane wave method. • Mathematical model was applied to different types of magnonic crystals. • Stop band formation and nonreciprocity were obtained
1D antiferromagnetism in spin‐alternating bimetallic chains
Coronado Miralles, Eugenio; Sapiña Navarro, Fernando; Drillon, M.; De Jongh, L.J.
1990-01-01
The magnetic and thermal properties of the ordered bimetallic chain CoNi(EDTA)⋅6H2O in the very low‐temperature range are reported. The magnetic behavior does not exhibit the characteristic features of 1D ferrimagnets, but a continuous decrease of χmT towards zero at absolute zero. This 1D antiferromagnetic behavior results from an accidental compensation between the moments located at the two sublattices. This behavior, as well as the specific‐heat results, are modeled on the basis of an Isi...
GIS-BASED 1-D DIFFUSIVE WAVE OVERLAND FLOW MODEL
KALYANAPU, ALFRED [Los Alamos National Laboratory; MCPHERSON, TIMOTHY N. [Los Alamos National Laboratory; BURIAN, STEVEN J. [NON LANL
2007-01-17
This paper presents a GIS-based 1-d distributed overland flow model and summarizes an application to simulate a flood event. The model estimates infiltration using the Green-Ampt approach and routes excess rainfall using the 1-d diffusive wave approximation. The model was designed to use readily available topographic, soils, and land use/land cover data and rainfall predictions from a meteorological model. An assessment of model performance was performed for a small catchment and a large watershed, both in urban environments. Simulated runoff hydrographs were compared to observations for a selected set of validation events. Results confirmed the model provides reasonable predictions in a short period of time.
Quantum electrodynamics with 1D arti cial atoms
Javadi, Alisa
A 1D atom, a single quantum emitter coupled to a single optical mode, exhibits rich quantum electrodynamic (QED) e_ects and is thought to be the key ingredient for many applications in quantuminformation processing. Single quantum dots (QD) in photonic-crystal waveguides (PCW) constitute a robust...... photons as expected from the theory. The value of g(2)(0) is around 1.08. The results con_rm the observation of an on-chip giant optical nonlinearity and the 1D atom behavior. Another direction in this thesis has been to investigate the e_ect of Anderson localization on the electrodynamics of QDs in PCWs...
Array tomography: imaging stained arrays.
Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J
2010-11-01
Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time-consuming and require some practice to perfect. In this protocol, tissue arrays are imaged using conventional wide-field fluorescence microscopy. Images can be captured manually or, with the appropriate software and hardware, the process can be automated. PMID:21041399
Array tomography: production of arrays.
Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J
2010-11-01
Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time consuming and require some practice to perfect. This protocol describes the sectioning of embedded tissues and the mounting of the serial arrays. The procedures require some familiarity with the techniques used for ultramicrotome sectioning for electron microscopy. PMID:21041397
NEW FEATURES OF HYDRUS-1D, VERSION 3.0
This paper briefly summarizes new features in version 3.0 of HYDRUS-1D, released in May 2005, as compared to version 2.1. The new features are a) new approaches to simulate preferential and nonequilibrium water flow and solute transport, b) a new hysteresis module that avoids the effects of pumpin...
Optical properties of LEDs with patterned 1D photonic crystal
Hronec, P.; Kuzma, A.; Å kriniarová, J.; Kováč, J.; Benčurová, A.; Haščík, Å.; Nemec, P.
2015-08-01
In this paper we focus on the application of the one-dimensional photonic crystal (1D PhC) structures on the top of Al0.295Ga0.705As/GaAs multi-quantum well light emitting diode (MQW LED). 1D PhC structures with periods of 600 nm, 700 nm, 800 nm, and 900 nm were fabricated by the E-Beam Direct Write (EBDW) Lithography. Effect of 1D PhC period on the light extraction enhancement was studied. 1D PhC LED radiation profiles were obtained from Near Surface Light Emission Images (NSLEI). Measurements showed the strongest light extraction enhancement using 800 nm period of PhC. Investigation of PhC LED radiation profiles showed strong light decoupling when light reaches PhC structure. Achieved LEE was from 22.6% for 600 nm PhC LED to 47.0% for 800 nm PhC LED. LED with PhC structure at its surface was simulated by FDTD simulation method under excitation of appropriate launch field.
Nonlinear ac conductivity of interacting 1d electron systems
Rosenow, Bernd; Nattermann, Thomas
2004-01-01
We consider low energy charge transport in one-dimensional (1d) electron systems with short range interactions under the influence of a random potential. Combining RG and instanton methods, we calculate the nonlinear ac conductivity and discuss the crossover between the nonanalytic field dependence of the electric current at zero frequency and the linear ac conductivity at small electric fields and finite frequency.
A 1D wavelet filtering for ultrasound images despeckling
Dahdouh, Sonia; Dubois, Mathieu; Frenoux, Emmanuelle; Osorio, Angel
2010-03-01
Ultrasound images appearance is characterized by speckle, shadows, signal dropout and low contrast which make them really difficult to process and leads to a very poor signal to noise ratio. Therefore, for main imaging applications, a denoising step is necessary to apply successfully medical imaging algorithms on such images. However, due to speckle statistics, denoising and enhancing edges on these images without inducing additional blurring is a real challenging problem on which usual filters often fail. To deal with such problems, a large number of papers are working on B-mode images considering that the noise is purely multiplicative. Making such an assertion could be misleading, because of internal pre-processing such as log compression which are done in the ultrasound device. To address those questions, we designed a novel filtering method based on 1D Radiofrequency signal. Indeed, since B-mode images are initially composed of 1D signals and since the log compression made by ultrasound devices modifies noise statistics, we decided to filter directly the 1D Radiofrequency signal envelope before log compression and image reconstitution, in order to conserve as much information as possible. A bi-orthogonal wavelet transform is applied to the log transform of each signal and an adaptive 1D split and merge like algorithm is used to denoise wavelet coefficients. Experiments were carried out on synthetic data sets simulated with Field II simulator and results show that our filter outperforms classical speckle filtering methods like Lee, non-linear means or SRAD filters.
Scattering approach to classical quasi-1D transport
Kogan, Eugene
1996-01-01
General dynamical transport of classical particles in disordered quasi-1D samples is viewed in the framework of scattering approach. Simple equation for the transfer-matrix is obtained within this unified picture. In the case of diffusive transport the solution of this equation exactly coincides with the solution of diffusion equation.
Simulation of Organic Solar Cells Using AMPS-1D Program
Samah G. Babiker
2012-03-01
Full Text Available The analysis of microelectronic and photonic structure in one dimension program [AMPS-1D] program has been successfully used to study inorganic solar cells. In this work the program has been used to optimize the performance of the organic solar cells. The cells considered consist of poly(2-methoxy-5-(3,7- dimethyloctyloxy-1,4-phenylenevinylene [MDMO-PPV
Quantitative 1D saturation profiles on chalk by NMR
Olsen, Dan; Topp, Simon; Stensgaard, Anders;
1996-01-01
Quantitative one-dimensional saturation profiles showing the distribution of water and oil in chalk core samples are calculated from NMR measurements utilizing a 1D CSI spectroscopy pulse sequence. Saturation profiles may be acquired under conditions of fluid flow through the sample. Results reveal...
Large Time existence For 1D Green-Naghdi equations
Israwi, Samer
2009-01-01
We consider here the $1D $ Green-Naghdi equations that are commonly used in coastal oceanography to describe the propagation of large amplitude surface waves. We show that the solution of the Green-Naghdi equations can be constructed by a standard Picard iterative scheme so that there is no loss of regularity of the solution with respect to the initial condition.
Full Text Available 1D6R 大豆 Soybean Glycine max (L.) Merrill Bowman-Birk Type Proteinase Inhibitor Precursor Glyci ... Warkentin, G.Wenzl, P.Flecker Crystal Structure Of Cancer ... Chemopreventive Bowman-Birk Inhibitor In Ternary C ...
Bessel Series in the Space H1(D)%H1(D)空间的Bessel级数
木乐华
2001-01-01
An identity concerning the partial sums of Bessel series and power series for H1(D) functions is given.Based on it,many of precise extimates about the deviation of the partial sums of Bessel series can be obtained.%本文给出关于H1(D)空间中函数的Bessel级数的部分和用幂级数的部分和表示的一个恒等式.基于它，可以得到Bessel级数部分和偏差的诸多精确估计.
3-D Imaging Using Row-Column-Addressed Arrays With Integrated Apodization
Christiansen, Thomas Lehrmann; Rasmussen, Morten Fischer; Bagge, Jan Peter;
2015-01-01
This paper demonstrates the fabrication, characterization, and experimental imaging results of a 62+62 element λ/2-pitch row-column-addressed capacitive micromachined ultrasonic transducer (CMUT) array with integrated apodization. A new fabrication process was used to manufacture a 26.3 mm by 26......Pa, and the sensitivity was 0.299 ± 0.090 V/Pa. The nearest neighbor crosstalk level was -23.9 ± 3.7 dB, while the transmit-to-receive-elements crosstalk level was -40.2 ± 3.5 dB. Imaging of a 0.3-mm-diameter steel wire using synthetic transmit focusing with 62 single-element emissions demonstrated axial and lateral...... FWHMs of 0.71 mm and 1.79 mm (f-number: 1.4), respectively, compared with simulated axial and lateral FWHMs of 0.69 mm and 1.76 mm. The dominant ghost echo was reduced by 15.8 dB in measurements using the integrated apodization compared with the disabled configuration. The effect was reproduced...
1D3V PIC simulation of propagation of relativistic electron beam in an inhomogeneous plasma
Shukla, Chandrashekhar; Patel, Kartik
2015-01-01
A recent experimental observation has shown efficient transport of Mega Ampere of electron currents through aligned carbon nanotube arrays [Phys. Rev Letts. 108, 235005 (2012)]. The result was subsequently interpreted on the basis of suppression of the filamentation instability in an inhomogeneous plasma [Phys. Plasmas 21, 012108 (2014)]. This inhomogeneity forms as a result of the ionization of the carbon nanotubes. In the present work a full 1D3V Particle-in-Cell (PIC) simulations have been carried out for the propagation of relativistic electron beams (REB) through an inhomogeneous background plasma. The suppression of the filamentation instability, responsible for beam divergence, is shown. The simulation also confirms that in the nonlinear regime too the REB propagation is better when it propagates through a plasma whose density is inhomogeneous transverse to the beam. The role of inhomogeneity scale length, its amplitude and the transverse beam temperature etc., in the suppression of the instability is ...
D1-D5-P microstates at the cap
Giusto, Stefano; Mathur, Samir D; Turton, David
2012-01-01
The geometries describing D1-D5-P bound states in string theory have three regions: flat asymptotics, an anti-de Sitter throat, and a 'cap' region at the bottom of the throat. We identify the CFT description of a known class of supersymmetric D1-D5-P microstate geometries which describe degrees of freedom in the cap region. The class includes both regular solutions and solutions with conical defects, and generalizes configurations with known CFT descriptions: a parameter related to spectral flow in the CFT is generalized from integer to fractional values. We provide strong evidence for this identification by comparing the massless scalar excitation spectrum between gravity and CFT and finding exact agreement.
On the 1D Coulomb Klein-Gordon equation
For a single particle of mass m experiencing the potential -α/vertical bar x vertical bar, the 1D Klein-Gordon equation is mathematically underdefined even when α 2 the ground-state energy E decreases through zero, and soon after that mR reaches a finite critical value below which E becomes complex, signalling a breakdown of the single-particle theory. At this critical point of the curve E(mR) the Klein-Gordon norm changes sign: the curve has a lower branch describing a bound antiparticle state, with positive energy -E, which exists for mR between the critical and some higher value where E reaches -m. Though apparently unanticipated in this context, similar scenarios are in fact familiar for strong short-range potentials (1D or 3D), and also for strong 3D Coulomb potentials with α of order unity
Fuzzball solutions and D1-D5 microstates
Skenderis, K; Skenderis, Kostas; Taylor, Marika
2006-01-01
We revisit the relation between fuzzball solutions and D1-D5 microstates. A consequence of the fact that the RR ground states (in the usual basis) are eigenstates of the R-charge is that only neutral operators can have non-vanishing expectation values on these states. We compute the holographic 1-point functions of the fuzzball solutions and find that charged chiral primaries have non-zero expectation values, except when the curve characterizing the solution is circular. The non-zero vevs reflect the fact that a generic curve breaks R-symmetry completely. This implies that fuzzball solutions (excepting circular ones) can only correspond to superpositions of RR states. We construct new solutions by appropriately superimposing fuzzball solutions that have vanishing vevs for all charged chiral primary operators and can therefore correspond to D1-D5 microstates.
Dentin dysplasia type 1d: A rare case
Sujit Ranjan Sahoo; Sonia Aggarwal
2014-01-01
Dentin dysplasia is a rare hereditary disturbance of dentin formation characterized by a defective dentin development with clinically normal-appearing crowns, severe hypermobility of teeth and spontaneous dental abscesses or cysts. Radiographic analysis shows obliteration of all pulp chambers by pulp stones, short, blunted and malformed or absent roots, peri-apical radiolucencies of noncarious teeth. We present a case of dentin dysplasia type 1d in a 19-year-old boy along with the clinical, r...
Waves in a 1D electrorheological dusty plasma lattice
Rosenberg, M.
2015-08-01
The behavior of waves in a one-dimensional (1D) dusty plasma lattice where the dust interacts via Yukawa and electric dipole interactions is discussed theoretically. This study is motivated by recent reports on electrorheological dusty plasmas (e.g. Ivlev et al. 2008 Phys. Rev. Lett. 100, 095003) where the dipole interaction arises due to an external uniaxial AC electric field that distorts the Debye sphere surrounding each grain. Application to possible dusty plasma experimental parameters is discussed.
Blind Detection of Severely Blurred 1D Barcode
Dridi, Noura; Delignon, Yves; Sawaya, Wadih; Septier, François
2010-01-01
In this paper, we present a joint blind channel estimation and symbol detection for decoding a blurred and noisy 1D barcode captured image. From an information transmission point of view, we show that the channel impulse response, the noise power and the symbols can be efficiently estimated by taking into account the signal structure such as the cyclostationary property of the hidden Markov process to estimate. Based on the Expectation-Maximisation method, we show that the new algorithm offer...
A study of slow light in 1D photonic crystals
Yudistira, D.; Hoekstra, H.J.W.M.; Hammer, M; Marpaung, D.A.I.
2005-01-01
Slow light (SL) states corresponding to wavelength regions near the bandgap edge of grating structure are known to show strong field enhancement. Such states may be excited efficiently by well-optimised adiabatic transitions in such structures, e.g., by slowly turning on the modulation depth. To study adiabatic excitations, a detailed research in 1D is performed to obtain insight into the relation between the device parameters and properties like enhancement and modal reflection. The results ...
Theory of slow light excitation in 1D photonic crystals
Yudistira, D.; Marpaung, D.A.I.; Handoyo, H.P.; Hoekstra, H.J.W.M.; Hammer, M; Tjia, M.O.; Iskandar, A.A.
2004-01-01
Slow light (SL) states corresponding to wavelength regions near the bandgap edge of grated structures are known to show strong eld enhancement. Such states may be excited efciently by well-optimised adiabatic transitions in grating structures, e.g., by slowly turning on the modulation depth. To study adiabatic excitations, a detailed investigation in 1D is performed to obtain insight into the relation between the device parameters and properties like eld enhancement and modal reection. The re...
Coupling of Nod1D and HOTCHANNEL: static case
In this work the joining of the programs Nod1D and HOTCHANNEL, developed in the National Polytechnic Institute (IPN) and in the Electrical Research Institute (IIE) respectively is described. The first one allows to study the neutronic of a nuclear reactor and the second one allows to carry out the analysis of hot channel of a Boiling Water Reactor (BWR). Nod1 D is a program that it solves by nodal methods type finite element those diffusion equations in multigroup, and it is the static part of Nod Kin that it solves the diffusion equation in their time dependent part. For another side HOTCHANNEL is based on a mathematical model constituted by four conservation equations (two of mass conservation, one of motion quantity and one of energy), which are solved applying one discretization in implicit finite differences. Both programs have been verified in independent form using diverse test problems. In this work the modifications that were necessary to carry out to both for obtaining a coupled program that it provides the axial distribution of the neutron flux, the power, the burnup and the void fraction, among others parameters as much as neutronic as thermal hydraulics are described. Those are also mentioned limitations, advantages and disadvantages of the final product to which has been designated Nod1 D-HotChn. Diverse results for the Cycle 1 of the Laguna Verde Unit 1 reactor of the Nucleo electric central comparing them with those obtained directly with the CoreMasterPresto code are provided. (Author)
Supported plasma-made 1D heterostructures: perspectives and applications
Borras, Ana; Macias-Montero, Manuel; Romero-Gomez, Pablo; Gonzalez-Elipe, Agustin R.
2011-05-01
Plasma-related methods have been widely used in the fabrication of carbon nanotubes and nanofibres (NFs) and semiconducting inorganic nanowires (NWs). A natural progression of the research in the field of 1D nanostructures is the synthesis of multicomponent NWs and NFs. In this paper we review the state of the art of the fabrication by plasma methods of 1D heterostructures including applications and perspectives. Furthermore, recent developments on the use of metal seeds (Ag, Au, Pt) to obtain metal@oxide nanostructures are also extensively described. Results are shown for various metal substrates, either metal foils or supported nanoparticles/thin films of the metal where the effects of the size, surface coverage, percolation degree and thickness of the metal seeds have been systematically evaluated. The possibilities of the process are illustrated by the preparation of nanostructured films and supported NFs of different metal@oxides (Ag, Au and SiO2, TiO2, ZnO). Particularly, in the case of silver, the application of an oxygen plasma treatment prior to the deposition of the oxide was critical for efficiently controlling the growth of the 1D heterostructures. A phenomenological model is proposed to account for the thin-film nanostructuring and fibre formation by considering basic phenomena such as stress relaxation, inhomogeneities in the plasma sheath electrical field and the local disturbance of the oxide growth.
Supported plasma-made 1D heterostructures: perspectives and applications
Plasma-related methods have been widely used in the fabrication of carbon nanotubes and nanofibres (NFs) and semiconducting inorganic nanowires (NWs). A natural progression of the research in the field of 1D nanostructures is the synthesis of multicomponent NWs and NFs. In this paper we review the state of the art of the fabrication by plasma methods of 1D heterostructures including applications and perspectives. Furthermore, recent developments on the use of metal seeds (Ag, Au, Pt) to obtain metal-oxide nanostructures are also extensively described. Results are shown for various metal substrates, either metal foils or supported nanoparticles/thin films of the metal where the effects of the size, surface coverage, percolation degree and thickness of the metal seeds have been systematically evaluated. The possibilities of the process are illustrated by the preparation of nanostructured films and supported NFs of different metal-oxides (Ag, Au and SiO2, TiO2, ZnO). Particularly, in the case of silver, the application of an oxygen plasma treatment prior to the deposition of the oxide was critical for efficiently controlling the growth of the 1D heterostructures. A phenomenological model is proposed to account for the thin-film nanostructuring and fibre formation by considering basic phenomena such as stress relaxation, inhomogeneities in the plasma sheath electrical field and the local disturbance of the oxide growth.
MARG1D: One dimensional outer region matching data code
A code MARG1D has been developed which computes outer region matching data of the one dimensional Newcomb equation. Matching data play an important role in the resistive (and non ideal) Magneto-hydrodynamic (MHD) stability analysis in a tokamak plasma. The MARG1D code computes matching data by using the boundary value method or by the eigenvalue method. Variational principles are derived for the problems to be solved and a finite element method is applied. Except for the case of marginal stability, the eigenvalue method is equivalent to the boundary value method. However, the eigenvalue method has the several advantages: it is a new method of ideal MHD stability analysis for which the marginally stable state can be identified, and it guarantees numerical stability in computing matching data close to marginal stability. We perform detailed numerical experiments for a model equation with analytical solutions and for the Newcomb equation in the m=1 mode theory. Numerical experiments show that MARG1D code gives the matching data with numerical stability and high accuracy. (author)
Domain walls and instantons in N=1, d=4 supergravity
Huebscher, M; Ortin, T
2009-01-01
We study the supersymmetric sources of (multi-) domain-wall and (multi-) instanton solutions of generic N=1, d=4 supergravities, that is: the worldvolume effective actions for said supersymmetric topological defects. The domain-wall solutions naturally couple to the two 3-forms recently found as part of the N=1, d=4 tensor hierarchy (i.e. they have two charges in general) and their tension is the absolute value of the superpotential section L. The introduction of sources (we study sources with finite and vanishing thickness) is equivalent to the introduction of local coupling constants and results in dramatic changes of the solutions. Our results call for a democratic reformulation of N=1,d=4 supergravity in which coupling constants are, off-shell, scalar fields. The effective actions for the instantons are always proportional to the coordinate orthogonal to the twist-free embedding of the null-geodesic (in the Wick-rotated scalar manifold) describing the instanton. We show their supersymmetry and find the as...
Development of 1D Liner Compression Code for IDL
Shimazu, Akihisa; Slough, John; Pancotti, Anthony
2015-11-01
A 1D liner compression code is developed to model liner implosion dynamics in the Inductively Driven Liner Experiment (IDL) where FRC plasmoid is compressed via inductively-driven metal liners. The driver circuit, magnetic field, joule heating, and liner dynamics calculations are performed at each time step in sequence to couple these effects in the code. To obtain more realistic magnetic field results for a given drive coil geometry, 2D and 3D effects are incorporated into the 1D field calculation through use of correction factor table lookup approach. Commercial low-frequency electromagnetic fields solver, ANSYS Maxwell 3D, is used to solve the magnetic field profile for static liner condition at various liner radius in order to derive correction factors for the 1D field calculation in the code. The liner dynamics results from the code is verified to be in good agreement with the results from commercial explicit dynamics solver, ANSYS Explicit Dynamics, and previous liner experiment. The developed code is used to optimize the capacitor bank and driver coil design for better energy transfer and coupling. FRC gain calculations are also performed using the liner compression data from the code for the conceptual design of the reactor sized system for fusion energy gains.
Examining Prebiotic Chemistry Using O(^1D) Insertion Reactions
Hays, Brian M.; Laas, Jacob C.; Weaver, Susanna L. Widicus
2013-06-01
Aminomethanol, methanediol, and methoxymethanol are all prebiotic molecules expected to form via photo-driven grain surface chemistry in the interstellar medium (ISM). These molecules are expected to be precursors for larger, biologically-relevant molecules in the ISM such as sugars and amino acids. These three molecules have not yet been detected in the ISM because of the lack of available rotational spectra. A high resolution (sub)millimeter spectrometer coupled to a molecular source is being used to study these molecules using O(^1D) insertion reactions. The O(^1D) chemistry is initiated using an excimer laser, and the products of the insertion reactions are adiabatically cooled using a supersonic expansion. Experimental parameters are being optimized by examination of methanol formed from O(^1D) insertion into methane. Theoretical studies of the structure and reaction energies for aminomethanol, methanediol, and methoxymethanol have been conducted to guide the laboratory studies once the methanol experiment has been optimized. The results of the calculations and initial experimental results will be presented.
Coupling of Nod1D and HOTCHANNEL: static case; Acoplamiento de Nod1D y HOTCHANNEL: caso estatico
Gomez T, A.M. [IPN-ESFM, 07738 Mexico D.F. (Mexico); Ovando C, R. [IIE-Gcia. de Energia Nuclear, Cuernavaca, Morelos (Mexico)]. e-mail: rovando@iie.org.mx
2003-07-01
In this work the joining of the programs Nod1D and HOTCHANNEL, developed in the National Polytechnic Institute (IPN) and in the Electrical Research Institute (IIE) respectively is described. The first one allows to study the neutronic of a nuclear reactor and the second one allows to carry out the analysis of hot channel of a Boiling Water Reactor (BWR). Nod1 D is a program that it solves by nodal methods type finite element those diffusion equations in multigroup, and it is the static part of Nod Kin that it solves the diffusion equation in their time dependent part. For another side HOTCHANNEL is based on a mathematical model constituted by four conservation equations (two of mass conservation, one of motion quantity and one of energy), which are solved applying one discretization in implicit finite differences. Both programs have been verified in independent form using diverse test problems. In this work the modifications that were necessary to carry out to both for obtaining a coupled program that it provides the axial distribution of the neutron flux, the power, the burnup and the void fraction, among others parameters as much as neutronic as thermal hydraulics are described. Those are also mentioned limitations, advantages and disadvantages of the final product to which has been designated Nod1 D-HotChn. Diverse results for the Cycle 1 of the Laguna Verde Unit 1 reactor of the Nucleo electric central comparing them with those obtained directly with the CoreMasterPresto code are provided. (Author)
Extended-Range Ultrarefractive 1D Photonic Crystal Prisms
Ting, David Z.
2007-01-01
A proposal has been made to exploit the special wavelength-dispersive characteristics of devices of the type described in One-Dimensional Photonic Crystal Superprisms (NPO-30232) NASA Tech Briefs, Vol. 29, No. 4 (April 2005), page 10a. A photonic crystal is an optical component that has a periodic structure comprising two dielectric materials with high dielectric contrast (e.g., a semiconductor and air), with geometrical feature sizes comparable to or smaller than light wavelengths of interest. Experimental superprisms have been realized as photonic crystals having three-dimensional (3D) structures comprising regions of amorphous Si alternating with regions of SiO2, fabricated in a complex process that included sputtering. A photonic crystal of the type to be exploited according to the present proposal is said to be one-dimensional (1D) because its contrasting dielectric materials would be stacked in parallel planar layers; in other words, there would be spatial periodicity in one dimension only. The processes of designing and fabricating 1D photonic crystal superprisms would be simpler and, hence, would cost less than do those for 3D photonic crystal superprisms. As in 3D structures, 1D photonic crystals may be used in applications such as wavelength-division multiplexing. In the extended-range configuration, it is also suitable for spectrometry applications. As an engineered structure or artificially engineered material, a photonic crystal can exhibit optical properties not commonly found in natural substances. Prior research had revealed several classes of photonic crystal structures for which the propagation of electromagnetic radiation is forbidden in certain frequency ranges, denoted photonic bandgaps. It had also been found that in narrow frequency bands just outside the photonic bandgaps, the angular wavelength dispersion of electromagnetic waves propagating in photonic crystal superprisms is much stronger than is the angular wavelength dispersion obtained
BGK electron solitary waves: 1D and 3D
L.-J. Chen
2002-01-01
Full Text Available This paper presents new results for 1D BGK electron solitary wave (phase-space electron hole solutions and, based on the new results, extends the solutions to include the 3D electrical interaction (E ~ 1/r 2 of charged particles. Our approach for extending to 3D is to solve the nonlinear 3D Poisson and 1D Vlasov equations based on a key feature of 1D electron hole (EH solutions; the positive core of an EH is screened by electrons trapped inside the potential energy trough. This feature has not been considered in previous studies. We illustrate this key feature using an analytical model and argue that the feature is independent of any specific model. We then construct azimuthally symmetric EH solutions under conditions where electrons are highly field-aligned and ions form a uniform background along the magnetic field. Our results indicate that, for a single humped electric potential, the parallel cut of the perpendicular component of the electric field (E⊥ is unipolar and that of the parallel component (E|| bipolar, reproducing the multi-dimensional features of the solitary waves observed by the FAST satellite. Our analytical solutions presented in this article capture the 3D electric interaction and the observed features of (E|| and E⊥. The solutions predict a dependence of the parallel width-amplitude relation on the perpendicular size of EHs. This dependence can be used in conjunction with experimental data to yield an estimate of the typical perpendicular size of observed EHs; this provides important information on the perpendicular span of the source region as well as on how much electrostatic energy is transported by the solitary waves.
1D-transport properties of single superconducting lead nanowires
Michotte, S.; Mátéfi-Tempfli, Stefan; Piraux, L.
2003-01-01
nanowire is small enough to ensure a 1D superconducting regime in a wide temperature range below T. The non-zero resistance in the superconducting state and its variation caused by fluctuations of the superconducting order parameter were measured versus temperature, magnetic field, and applied DC current......We report on the transport properties of single superconducting lead nanowires grown by an electrodeposition technique, embedded in a nanoporous track-etched polymer membrane. The nanowires are granular, have uniform diameter of ̃40 nm and a very large aspect ratio (̃500). The diameter of the...
Breakdown of 1D water wires inside Charged Carbon Nanotubes
Pant, Shashank
2016-01-01
Using Molecular Dynamics approach we investigated the structure, dynamics of water confined inside pristine and charged 6,6 carbon nanotubes (CNTs). This study reports the breakdown of 1D water wires and the emergence of triangular faced water on incorporating charges in 6,6 CNTs. Incorporation of charges results in high potential barriers to the flipping of water molecules due to the formation of a large number of hydrogen bonds. The PMF analyses show the presence of ~2 kcal/mol barrier for the movement of water inside pristine CNT and almost negligible barrier in charged CNTs.
Restrained Dark $U(1)_d$ at Low Energies
Correia, F C
2016-01-01
We investigate a spontaneously broken $U(1)_d$ gauge symmetry with a muon-specific dark Higgs. Our first goal is to verify how the presence of a new dark Higgs, $\\phi$, and a dark gauge boson, $V$, can simultaneously face the anomalies from the muon magnetic moment and the proton charge radius. Secondly, by assuming that $V$ must decay to an electron-positron pair, we explore the corresponding parameter space determined with the low energy constraints coming from $ K \\to \\mu X$, electron $(g-2)_e$, $K \\to \\mu \
Phthalocyanine based 1D nanowires for device applications
Saini, Rajan; Mahajan, Aman; Bedi, R. K.
2012-06-01
1D nanowires (NWs) of Cu (II) 1,4,8,11,15,18,22,25-octabutoxy-29H,31H-Phthalocyanine (CuPc(OBu)8) molecule have been grown on different substrates by cost effective solution processing technique. The density of NWs is found to be strongly dependent on the concentration of solution. The possible formation mechanism of these structures is π-π interaction between phthalocyanine molecules. The improved conductivity of these NWs as compared to spin coated film indicates their potential for molecular device applications.
Coherent thermal conductance of 1-D photonic crystals
We present an exact calculation of coherent thermal conductance in 1-D multilayer photonic crystals using the S-matrix method. In particular, we study the thermal conductance in a bilayer structure of Si/vacuum or Al2O3/vacuum slabs by means of the exact radiative heat flux expression. Based on the results obtained for the Al2O3/vacuum structure we show by comparison with previous works that the material losses and (localized) surface modes supported by the inner layers play a fundamental role and cannot be omitted in the definition of thermal conductance. Our results could have significant implications in the conception of efficient thermal barriers.
Coherent thermal conductance of 1-D photonic crystals
Tschikin, Maria; Ben-Abdallah, Philippe; Biehs, Svend-Age
2012-10-01
We present an exact calculation of coherent thermal conductance in 1-D multilayer photonic crystals using the S-matrix method. In particular, we study the thermal conductance in a bilayer structure of Si/vacuum or Al2O3/vacuum slabs by means of the exact radiative heat flux expression. Based on the results obtained for the Al2O3/vacuum structure we show by comparison with previous works that the material losses and (localized) surface modes supported by the inner layers play a fundamental role and cannot be omitted in the definition of thermal conductance. Our results could have significant implications in the conception of efficient thermal barriers.
Spatial coherence of polaritons in a 1D channel
Savenko, I. G., E-mail: savenko.j@mail.ru [Russian Academy of Sciences, Academic University, Research and Education Center of Nanotechnologies (Russian Federation); Iorsh, I. V. [National Research University of Information Technologies, Mechanics and Optics (Russian Federation); Kaliteevski, M. A. [Russian Academy of Sciences, Academic University, Research and Education Center of Nanotechnologies (Russian Federation); Shelykh, I. A. [University of Iceland, Science Institute (Iceland)
2013-01-15
We analyze time evolution of spatial coherence of a polariton ensemble in a quantum wire (1D channel) under constant uniform resonant pumping. Using the theoretical approach based on the Lindblad equation for a one-particle density matrix, which takes into account the polariton-phonon and excitonexciton interactions, we study the behavior of the first-order coherence function g{sup 1} for various pump intensities and temperatures in the range of 1-20 K. Bistability and hysteresis in the dependence of the first-order coherence function on the pump intensity is demonstrated.
A Godunov method for Lagrangian hydrodynamics in 1D
Crowley, W.P.
1987-01-15
For transient problems involving strong shocks, the artificial viscosity method has been the standard in numerical hydrodynamics for many years. An alternative approach was suggested by Godunov and it is gaining acceptance. We consider a Godunov method for 1D Lagrangian calculations and show that in the case of a strong shock moving through a nonuniform mesh the Godunov solution is superior to the artificial viscosity solution. For uniform mesh shock problems in spherical geometry the two methods give comparable results. 4 refs., 9 figs.
A 1D analysis of two high order MOC methods
The work presented here provides two different methods for evaluating angular fluxes along long characteristics. One is based off a projection of the 1D transport equation onto a complete set of Legendre polynomials, while the other uses the 1D integral transport equation to evaluate the angular flux values at specific points along each track passing through a cell. The Moment Long Characteristic (M-LC) method is shown to provide 2(P+1) spatial convergence and significant gains in accuracy with the addition of only a few spatial degrees of freedom. The M-LC method, though, is shown to be ill-conditioned at very high order and for optically thin geometries. The Point Long Characteristic (P-LC) method, while less accurate, significantly improves stability to problems with optically thin cells. The P-LC method is also more flexible, allowing for extra angular flux evaluations along a given track to give a more accurate representation of the shape along each track. This is at the expense of increasing the degrees of freedom of the system, though, and requires an increase in memory storage. This work concludes that both may be used simultaneously within the same geometry to provide the best mix of accuracy and stability possible. (authors)
1-D DCT Using Latency Efficient Floating Point Algorithms
Viswanath Gowd A, Yedukondala Rao V, T. Shanmuganantham
2013-04-01
Full Text Available This paper presents the design of one-dimensional discrete cosine transform (DCT architecture for digital signal processing (DSP applications. DCT is a basic transformation for coding method which converts spatial domain to frequency domain of image. In 1-D DCT operation addition, subtraction, multiplication operations are required. These operations must be accurate, less latency. Floating point operations have dynamic range of representation, more accurate and perform millions of calculations per second. So the floating point operations are used for the above operations. In this floating point adder/subtractor is the most complex operation in a floating-point arithmetic and consists of many variable latency- and area dependent sub-operations. In floating-point addition implementations, latency is the primary performance bottleneck. So different types of floating point adder/subtractor algorithms such as LOD, LOP, Two-path are used to decrease the latency. The trade off is observed in 1-D DCT by changing different types of adders in place of summer. All architectures are designed and implemented using VHDL using Xillinx 13.1software.
Hamming Distance and Data Compression of 1-D CA
Raied Salman
2013-05-01
Full Text Available In this paper an application of von Neumann correct ion technique to the output string of some chaotic rules of 1-D Cellular Automata that are uns uitable for cryptographic pseudo random number generation due to their non uniform distribu tion of the binary elements is presented. The one dimensional (1-D Cellular Automata (CA Ru le space will be classified by the time run of Hamming Distance (HD. This has the advantage of determining the rules that have short cycle lengths and therefore deemed to be unsuitable for cryptographic pseudo random number generation. The data collected from evolution of ch aotic rules that have long cycles are subjected to the original von Neumann density corre ction scheme as well as a new generalized scheme presented in this paper and tested for stati stical testing fitness using Diehard battery of tests. Results show that significant improvement in the statistical tests are obtained when the output of a balanced chaotic rule are mutually excl usive ORed with the output of unbalanced chaotic rule that have undergone von Neumann densit y correction.
The Cosmological Mass Function with 1D Gravity
Monaco, P; Monaco, Pierluigi; Murante, Giuseppe
1999-01-01
The cosmological mass function problem is analyzed in full detail in the case of 1D gravity, with analytical, semi-analytical and numerical techniques. The extended Press & Schechter theory is improved by detailing the relation between smoothing radius and mass of the objects. This is done by introducing in the formalism the concept of a growth curve for the objects. The predictions of the extended Press & Schechter theory are compared to large N-body simulations of flat expanding 1D universes with scale-free power spectra of primordial perturbations. The collapsed objects in the simulations are located with a clump-finding algorithm designed to find regions that have undergone orbit crossing or that are in the multi-stream regime (these are different as an effect of the finite size of the multi-stream regions). It is found that the semi-analytical mass function theory, which has no free parameters, is able to recover the properties of collapsed objects both statistically and object by object. In part...
Modeling atrazine transport in soil columns with HYDRUS-1D
John Leju CELESTINO LADU
2011-09-01
Full Text Available Both physical and chemical processes affect the fate and transport of herbicides. It is useful to simulate these processes with computer programs to predict solute movement. Simulations were run with HYDRUS-1D to identify the sorption and degradation parameters of atrazine through calibration from the breakthrough curves (BTCs. Data from undisturbed and disturbed soil column experiments were compared and analyzed using the dual-porosity model. The study results show that the values of dispersivity are slightly lower in disturbed columns, suggesting that the more heterogeneous the structure is, the higher the dispersivity. Sorption parameters also show slight variability, which is attributed to the differences in soil properties, experimental conditions and methods, or other ecological factors. For both of the columns, the degradation rates were similar. Potassium bromide was used as a conservative non-reactive tracer to characterize the water movement in columns. Atrazine BTCs exhibited significant tailing and asymmetry, indicating non-equilibrium sorption during solute transport. The dual-porosity model was verified to best fit the BTCs of the column experiments. Greater or lesser concentration of atrazine spreading to the bottom of the columns indicated risk of groundwater contamination. Overall, HYDRUS-1D successfully simulated the atrazine transport in soil columns.
Study of 1D Strange Charmed Meson Family Using HQET
Pallavi Gupta
2016-01-01
Full Text Available Recently LHCb predicted spin 1 and spin 3 states Ds1⁎(2860 and Ds3⁎(2860 which are studied through their strong decays and are assigned to fit the 13D1 and 13D3 states in the charm spectroscopy. In this paper, using the heavy quark effective theory, we state that assigning Ds1⁎(2860 as the mixing of 13D1-23S1 states is rather a better justification to its observed experimental values than a pure state. We study its decay modes variation with hadronic coupling constant gxh and the mixing angle θ. We appoint spin 3 state Ds3⁎(2860 as the missing 1D 3-JP state and also study its decay channel behavior with coupling constant gyh. To appreciate the above results, we check the variation of decay modes for their spin partners states, that is, 1D2 and 1D2′, with their masses and strong coupling constant, that is, gxh and gyh. Our calculation using HQET approach gives mixing angle of the 13D1-23S1 state for Ds1⁎(2860 to lie in the range (-1.6 radians ≤θ≤-1.2 radians. Our calculation for coupling constant values gives gxh to lie within value range of 0.17–0.20 and gyh to be 0.40. We expect from experiments to observe this mixing angle to verify our results.
COLUMN, 1-D Migration for Various Physical Chemical Processes
1 - Description of problem or function: COLUMN2 is designed for studies of the effects various physicochemical processes on migration in one dimension. It solves the transport equation and can take into account dispersion, sorption, ion exchange, first and second order homogeneous chemical reactions. Spatial variations of input pulses and retention factors are possible. 2 - Method of solution: The Method of solution is based on a finite difference discretion followed by the application of the method of characteristics and two separate grid systems. 3 - Restrictions on the complexity of the problem: For computational reasons the number of components has been limited to 5 and the maximum number of second order reactions is 10. However, a re-dimensioning of all relevant arrays will allow for any number of components and reactions desired. Arrays should never be dimensioned larger than needed in order to save computation time. Five components and 10 second order reactions may seem a small number. However, larger simulations are often divided into smaller sub-problems for clarification purposes. The maximum number of grid points, default value 801, may be enlarged to re-dimensioning all relevant arrays
CHEN Chao; YANG Yu-lin; LI Wei-sheng; LIU Yun-ling; YI Zhuo; GUO Yang-hong; PANG Wen-qin
2005-01-01
The transformation of titanium phosphate from 1-D chiral- chain(JTP-A) to 2-D layer(TP-J1) has been carefully investigated. Through a hydrolysis-condensation self-assembly pathway, the crystals of TP-J1 can be obtained from the JTP-A phase under hydrothermal conditions. An intermediate material with zigzag chain during the transformation was observed by XRD characterization. A hypothesis of the transformation mechanism is also described in this article. It is noteworthy that ethylenediamine plays an important role in the transformation.
Simplified 1D modelling of the HGA test
Document available in extended abstract form only. The HGA test is located in the Mont Terri Rock Laboratory (Switzerland). It consists of a horizontal borehole of 1.00 m of diameter and 13.00 m of length excavated in the ultra-low permeable Opalinus clay. During the tunnel drilling, the Opalinus clay near the tunnel wall was damaged, giving rise to an EDZ (Excavation Damaged Zone) around the tunnel. A steel liner was placed along the 6.00 m close to the tunnel mouth in order to guarantee the stability. The last 4.00 m at the tunnel end were backfilled with gravel. Along the remaining 3.00 m, an inflatable rubber packer of 1.00 m in diameter, was installed and inflated, thereby compressing the EDZ that was created during the tunnel excavation. The test section was filled with de-aired water and care was taken in order to eliminate the air from this tunnel section. Subsequently, a series of water and gas injection tests were carried out with varying mega-packer pressure, whereby water or gas was injected into the test section and, due to the very low permeability of the intact Opalinus clay, forced to flow back along the EDZ. In order to model the water and gas flow through the EDZ, we have followed a two-track approach. On the one hand, a 2D axisymmetric numerical model using code-bright has been made. On the other hand, a 1D analytical-numerical model has been developed and implemented in an Excel spreadsheet, whereby the field equations defined on a 1D geometrical domain are numerically solved using the finite element method. The 1D model has been used in order to calibrate the 2D axisymmetric model. Both the Opalinus clay and the EDZ will be considered to be porous media, with an incompressible solid phase (clay), an incompressible liquid phase (water and air) and a gas phase (water and air). The properties of the liquid phase will be assumed to be independent of the concentration of dissolved air and the gas phase will be assumed to be a mixture of dry air and
Slug modeling with 1D two-fluid model
Simulations of condensation-induced water hammer with one-dimensional two-fluid model requires explicit modeling of slug formation, slug propagation, and in some cases slug decay. Stratified flow correlations that are more or less well known in 1D two-fluid models, are crucial for accurate description of the initial phase of the slug formation and slug propagation. Slug formation means transition to other flow regime that requires different set of correlations. To use such two-fluid model for condensation induced water hammer simulations, a single slug must be explicitly recognized and captured. In the present work two cases of condensation-induced water hammer simulations performed with WAHA code, are described and discussed: injection of cold liquid into horizontal pipe filled with steam and injection of hot steam into horizontal pipe partially filled with cold liquid. (author)
1D PIC simulation of relativistic Buneman instability
Buneman instability in the relativistic regime has been studied using a 1D electrostatic particle-in-cell code. In the non-relativistic case, Hirose et al. (Plasma Phys. 20, 481(1978)) has shown that breakdown of linear growth (saturation) occurs when |E|2/16πW0 ∼ ζomax, where W0 is the initial beam kinetic energy density and ζomax is maximum growth rate of the instability. In the weakly relativistic case, it has been confirmed using PIC simulation that scaling of saturation of Buneman instability follows a similar behavior as the non-relativistic case, whereas in the strongly relativistic case our simulation results show significant deviation from Hirose's results. In the strongly relativistic case, growth rate reduces due to relativistic corrections; so saturation occurs at a lower value compared to the non-relativistic/weakly relativistic case. (author)
Assessment of the 2D/1D implementation in MPACT
The 2D/1D method is used in the MPACT code to obtain 3D solutions of the Boltzmann transport equation for practical reactor geometries. The OECD C5G7 transport benchmark problem is used first to assess the accuracy of the method with a fixed set of cross-sections. The VERA Core Physics Progression Problems are then used to compare the accuracy of the transport solver using a 56-group library based on ENDFB-VII.0. Single assembly PWR designs are simulated, and the eigenvalue and pin powers are compared to continuous-energy Monte Carlo results. A 3x3 assembly cluster with a control rod inserted into the center assembly is then compared to Monte Carlo to assess the ability of MPACT to predict a control rod worth curve. Finally, MPACT is used to simulate the initial critical states of a full 3D initial core of a PWR at zero power conditions. (author)
1-D Molecular Chains of Thiophene on Ge(100)
Jeon, Seok Min; Jung, Soon Jung; Kim, Hyeong-Do; Lim, Do Kyung; Lee, Hangil; Kim, Sehun
2007-01-01
The adsorption geometry of thiophene on Ge(100) have been studied by high-resolution core-level photoemission spectroscopy (HRPES) using synchrotron radiation and scanning tunneling microscopy (STM). From the analysis of the Ge 3d, S 2p, and C 1s core-level photoemission spectra, we found three different adsorption geometries, which were assigned to a dative bonding feature, a [4+2] cycloaddition reaction product, and a desulfurization reaction product. Furthermore, we investigated that the ratio of the components induced by three adsorption geometries changed depending on the molecular coverage and the annealing temperature. At low coverage, the kinetically favorable dative bonding features favorably form 1-D molecular chains. Increasing the molecular coverage, the energetically more stable [4+2] cycloaddition reaction products are additionally created.
Fleury, Leesa M.; Moore, Guy D.
2016-05-01
If the axion exists and if the initial axion field value is uncorrelated at causally disconnected points, then it should be possible to predict the efficiency of cosmological axion production, relating the axionic dark matter density to the axion mass. The main obstacle to making this prediction is correctly treating the axion string cores. We develop a new algorithm for treating the axionic string cores correctly in 2+1 dimensions. When the axionic string cores are given their full physical string tension, axion production is about twice as efficient as in previous simulations. We argue that the string network in 2+1 dimensions should behave very differently than in 3+1 dimensions, so this result cannot be simply carried over to the physical case. We outline how to extend our method to 3+1D axion string dynamics.
Fleury, Leesa M
2016-01-01
If the axion exists and if the initial axion field value is uncorrelated at causally disconnected points, then it should be possible to predict the efficiency of cosmological axion production, relating the axionic dark matter density to the axion mass. The main obstacle to making this prediction is correctly treating the axion string cores. We develop a new algorithm for treating the axionic string cores correctly in 2+1 dimensions. When the axionic string cores are given their full physical string tension, axion production is about twice as efficient as in previous simulations. We argue that the string network in 2+1 dimensions should behave very differently than in 3+1 dimensions, so this result cannot be simply carried over to the physical case. We outline how to extend our method to 3+1D axion string dynamics.
Microlens Masses from 1-D Parallaxes and Heliocentric Proper Motions
Gould, Andrew
2014-01-01
One-dimensional (1-D) microlens parallaxes can be combined with heliocentric lens-source relative proper motion measurements to derive the lens mass and distance, as suggested by Ghosh et al. (2004). Here I present the first mathematical anlysis of this procedure, which I show can be represented as a quadratic equation. Hence, it is formally subject to a two-fold degeneracy. I show that this degeneracy can be broken in many cases using the relatively crude 2-D parallax information that is often available for microlensing events. I also develop an explicit formula for the region of parameter space where it is more difficult to break this degeneracy. Although no mass/distance measurements have yet been made using this technique, it is likely to become quite common over the next decade.
A 1-D morphodynamic model of postglacial valley incision
Tunnicliffe, Jon F.; Church, Michael
2015-11-01
Chilliwack River is typical of many Cordilleran valley river systems that have undergone dramatic Holocene degradation of valley fills that built up over the course of Pleistocene glaciation. Downstream controls on base level, mainly blockage of valleys by glaciers, led to aggradation of significant glaciofluvial and glaciolacustrine valley fills and fan deposits, subsequently incised by fluvial action. Models of such large-scale, long-term degradation present a number of important challenges since the evolution of model parameters, such as the rate of bedload transport and grain size characteristics, are governed by the nature of the deposit. Sediment sampling in the Chilliwack Valley reveals a complex sequence of very coarse to fine textural modes. We present a 1-D numerical morphodynamic model for the river-floodplain system tailored to conditions in the valley. The model is adapted to dynamically adjust channel width to optimize sediment transporting capacity and to integrate relict valley fill material as the channel incises through valley deposits. Sensitivity to model parameters is studied using four principal criteria: profile concavity, rate of downstream grain size fining, bed surface sand content, and the timescale to equilibrium. Model results indicate that rates of abrasion and coarsening of the grain size distributions exert the strongest controls on all of the interrelated model performance criteria. While there are a number of difficulties in satisfying all model criteria simultaneously, results indicate that 1-D models of valley bottom sedimentary systems can provide a suitable framework for integrating results from sediment budget studies and chronologies of sediment evacuation established from dating.
Accurate Insertion Loss Measurements of the Juno Patch Array Antennas
Chamberlain, Neil; Chen, Jacqueline; Hodges, Richard; Demas, John
2010-01-01
This paper describes two independent methods for estimating the insertion loss of patch array antennas that were developed for the Juno Microwave Radiometer instrument. One method is based principally on pattern measurements while the other method is based solely on network analyzer measurements. The methods are accurate to within 0.1 dB for the measured antennas and show good agreement (to within 0.1dB) of separate radiometric measurements.
Feng, Gang; Freund, L. B.
2010-06-01
Cubic layered heterostructures are indispensable features of many electronic devices; however, the lattice mismatch tends to induce defects, e.g. dislocations. Glissile 60° misfit dislocations (MDs) generally form in the early stage of strain relaxation. During annealing, each relaxing 60° dislocation compensated-pair (60DCP) (with canceling screw and interface-perpendicular edge components) may coalesce into a 90° (pure edge) dislocation, which is a possible mechanism for the reduction of threading dislocations (TDs) through annealing. In this paper, we calculate the formation energies of periodic one-dimensional (1D) and two-dimensional (2D) arrays on the basis of linear elasticity. Each 1D 60DCP array always has lower energy than its homogeneous counterpart. The situation of each 2D array (containing two mutually orthogonal 1D arrays) depends on the period difference δ between the two individual 1D arrays and the film thickness. If δ=0, each 2D 60DCP array has higher energy than its homogeneous counterpart, whereas the 2D 60DCP array is energetically more favorable for a larger δ and/or a thicker film. The analysis suggests a semiconductor-processing strategy to obtain 90° dislocation-dominant arrays and to reduce TDs. Furthermore, based on the criterion of zero energy change by inserting the last dislocation to complete an array, we calculate the equilibrium array period for various configurations, implying possible strain over-relaxation (>100%-relaxed condition) for a sufficiently thick film.
3D/1D Analysis of ICRF Antennas
Maggiora, Riccardo; Lancellotti, Vito; Vecchi, Giuseppe
2003-10-01
An innovative tool has been realized for the 3D/1D simulation of Ion Cyclotron Radio Frequency (ICRF), i.e. accounting for antennas in a realistic 3D geometry and with an accurate 1D plasma model. The approach to the problem is based on an integral-equation formulation for the self-consistent evaluation of the current distribution on the conductors. The environment has been subdivided in two coupled region: the plasma region and the vacuum region. The two problems are linked by means of a magnetic current (electric field) distribution on the aperture between the two regions. In the vacuum region all the calculations are executed in the spatial domain while in the plasma region an extraction in the spectral domain of some integrals is employed that permits to significantly reduce the integration support and to obtain a high numerical efficiency leading to the practical possibility of using a large number of sub-domain (rectangular or triangular) basis functions on each solid conductor of the system. The plasma enters the formalism of the plasma region via a surface impedance matrix; for this reason any plasma model can be used; at present the FELICE code has been adopted, that affords density and temperature profiles, and FLR effects. The source term directly models the TEM mode of the coax feeding the antenna and the current in the coax is determined self-consistently, giving the input impedance/admittance of the antenna itself. Calculation of field distributions (both magnetic and electric), useful for sheath considerations, is included. This tool has been implemented in a suite, called TOPICA, that is modular and applicable to ICRF antenna structures of arbitrary shape. This new simulation tool can assist during the detailed design phase and for this reason can be considered a "Virtual Prototyping Laboratory" (VPL). The TOPICA suite has been tested against assessed codes and against measurements and data of mock-ups and existing antennas. The VPL is being used in
Nonclassical Particle Transport in 1-D Random Periodic Media
Vasques, Richard; Slaybaugh, Rachel N
2016-01-01
We investigate the accuracy of the recently proposed nonclassical transport equation. This equation contains an extra independent variable compared to the classical transport equation (the path-length $s$), and models particle transport taking place in homogenized random media in which a particle's distance-to-collision is not exponentially distributed. To solve the nonclassical equation one needs to know the $s$-dependent ensemble-averaged total cross section, $\\Sigma_t(\\mu,s)$, or its corresponding path-length distribution function, $p(\\mu,s)$. We consider a 1-D spatially periodic system consisting of alternating solid and void layers, randomly placed in the $x$-axis. We obtain an analytical expression for $p(\\mu,s)$ and use this result to compute the corresponding $\\Sigma_t(\\mu,s)$. Then, we proceed to numerically solve the nonclassical equation for different test problems in rod geometry; that is, particles can move only in the directions $\\mu=\\pm 1$. To assess the accuracy of these solutions, we produce ...
The molecular spin filter constructed from 1D organic chain
We proposed a molecular spin filter, which is constructed from the 1D metallic organic chain (Fen+1(C6H4)n). The spin-polarized transport properties of the molecular spin filter are explored by combining density functional theory with nonequilibrium Green's function formalism. Theoretical results reveal that Fen+1(C6H4)n molecular chain exhibits robust spin filtering effect, and only the spin-down electrons can transmit through the molecular chain. At the given bias voltage window [−1 eV,1 eV], the calculated spin filter efficiency is close to 100% in the case of n≥3. We find that the effect of spin polarization origin from both Fen+1 and (C6H4)n. In addition, negative difference resistance behavior appears in Fen+1(C6H4)n molecular chain. The results can help us understand the spin transport properties of organic molecular chain. - Highlights: • Theoretical results reveal that Fen+1(C6H4)n molecular chain exhibits robust spin filtering effect. • The effect of spin polarization origin from both of Fen+1 and (C6H4)n. • Negative difference resistance behavior appears in Fen+1(C6H4)n molecular chain
Graphs on uniform points in [0,1]d
Appel, Martin J. B.; Russo, Ralph P.; Yang, King J.
1995-06-01
Statistical problems in pattern or structure recognition for a random multidimensional point set may be addressed by variations on the random graph model of Erdos and Renyui. The imposition of graph structure with a variable edge criterion on a large random point set allows a search for signature quantities or behavior under the given distributional hypothesis. The work is motivated by the question of how to make statistical inferences from sensed mine field data. This article describes recent results obtained in the following special cases. On independent random points U1,...,Un distributed uniformly on [0,1]d, a random graph Gn(x) is constructed in which two distinct such points are joined by an edge if the l(infinity )-distance between them is at most some prescribed value 0 graph are described. Almost-sure asymptotic rates of convergence/divergence are obtained for various quantities, including the maximum and minimum vertex degree of the random graph, its clique number, chromatic number, and independence number, as the number n of points becomes large and the edge distance x is allowed to vary with n. The connectivity distance cn, the smallest x such that Gn(x) is connected, and the largest nearest neighbor link dn, the smallest x such that Gn(x) has no vertices of degree zero, are asymptotic in ratio, as n becomes large, for d >= 2.
1D dynamic beam modulation: methods to counteract inertia effects
Dynamic modulation can be affected by inaccuracies when the required acceleration is larger than the highest allowed by the mechanical characteristics of the whole apparatus. In this study, inertia effects have been investigated with regard to the single absorber 1D modulation, analysing primarily how the acceleration performed by the modulating system affects the realization of 'single absorber' fluence profiles and the type of correction which could be devised. The observed percentage deviations from desired modulation at the lowest fluence coordinate of single minimum fluence profiles, when no correction is applied, were almost negligible for 'easy' modulations of the incident fluence (i.e. slow gradients); deviations became increasingly relevant as the moving absorber executed steeper gradients (a 17.6% higher dose being delivered in the minimum position when a 0.2 modulation is required). By applying the proposed corrections, the single absorber performances were improved to a satisfactory level, with a maximum deviation from desired modulation in the minima within 1.6%. (author)
Havlickova, E.; Fundamenski, W.; Subba, F.; Coster, D; Wischmeier, M; Fishpool, G.
2013-01-01
A 1D code modelling SOL transport parallel to the magnetic field (SOLF1D) is benchmarked with 2D simulations of MAST-U SOL performed via the SOLPS code for two different collisionalities. Based on this comparison, SOLF1D is then used to model the effects of divertor leg stretching in 1D, in support of the planned Super-X divertor on MAST. The aim is to separate magnetic flux expansion from volumetric power losses due to recycling neutrals by stretching the divertor leg either vertically or ra...
Havlickova, E; Subba, F; Coster, D; Wischmeier, M; Fishpool, G
2013-01-01
A 1D code modelling SOL transport parallel to the magnetic field (SOLF1D) is benchmarked with 2D simulations of MAST-U SOL performed via the SOLPS code for two different collisionalities. Based on this comparison, SOLF1D is then used to model the effects of divertor leg stretching in 1D, in support of the planned Super-X divertor on MAST. The aim is to separate magnetic flux expansion from volumetric power losses due to recycling neutrals by stretching the divertor leg either vertically or radially.
PRITAM PATIL; GANESH GAIKWAD; D R PATIL; JITENDRA NAIK
2016-06-01
1-D ZnO nanorods and PPy/1-D ZnO nanocomposites were prepared by the surfactant-assisted precipitation and in situ polymerization method, respectively. The synthesized nanorods and nanocomposites were characterized by UV–Vis spectrophotometer, Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD) and field emission scanning electron microscope (FE-SEM), which gave the evidence of 1-D ZnO nanorods, polymerization of pyrrole monomer and strong interaction between PPy and 1-D ZnO nanorods, respectively. Photocatalytic activity of 1-D ZnO nanorods was conducted by $3^3$ level full-factorial design to evaluate the effect of three independent process variables viz., dye concentration (crystal violet), catalyst concentration (1-D ZnO nanorods) and the reaction time on the preferred response: photodegradation efficiency (%). The PPy/1-D ZnO nanocompositeswere used for the sensing of NH$_3$, LPG, CO$_2$ and H$_2$S gases, respectively, at room temperature. It was observed that PPy/1-D ZnO nanocomposites with different 1-D ZnO nanorod weight ratios (15 and 25%) had better selectivity and sensitivity towards NH3 at room temperature.
Variable-range hopping in 2D quasi-1D electronic systems
A semi-phenomenological theory of variable-range hopping (VRH) is developed for two-dimensional (2D) quasi-one-dimensional (quasi-1D) systems such as arrays of quantum wires in the Wigner crystal regime. The theory follows the phenomenology of Efros, Mott and Shklovskii allied with microscopic arguments. We first derive the Coulomb gap in the single-particle density of states, g(ε), where ε is the energy of the charge excitation. We then derive the main exponential dependence of the electron conductivity in the linear (L), i.e. σ(T) ∼ exp [-(TL/T)γL], and current in the non-linear (NL), i.e. j(E) ∼ [-(ENL/E)γNL], response regimes (E is the applied electric field). Due to the strong anisotropy of the system and its peculiar dielectric properties we show that unusual, with respect to known results, Coulomb gaps open followed by unusual VRH laws, i.e. with respect to the disorder-dependence of TL and ENL and the values of γL and γNL. (author)
A new general 1-D vadose zone flow solution method
Ogden, Fred L.; Lai, Wencong; Steinke, Robert C.; Zhu, Jianting; Talbot, Cary A.; Wilson, John L.
2015-06-01
We have developed an alternative to the one-dimensional partial differential equation (PDE) attributed to Richards (1931) that describes unsaturated porous media flow in homogeneous soil layers. Our solution is a set of three ordinary differential equations (ODEs) derived from unsaturated flux and mass conservation principles. We used a hodograph transformation, the Method of Lines, and a finite water-content discretization to produce ODEs that accurately simulate infiltration, falling slugs, and groundwater table dynamic effects on vadose zone fluxes. This formulation, which we refer to as "finite water-content", simulates sharp fronts and is guaranteed to conserve mass using a finite-volume solution. Our ODE solution method is explicitly integrable, does not require iterations and therefore has no convergence limits and is computationally efficient. The method accepts boundary fluxes including arbitrary precipitation, bare soil evaporation, and evapotranspiration. The method can simulate heterogeneous soils using layers. Results are presented in terms of fluxes and water content profiles. Comparing our method against analytical solutions, laboratory data, and the Hydrus-1D solver, we find that predictive performance of our finite water-content ODE method is comparable to or in some cases exceeds that of the solution of Richards' equation, with or without a shallow water table. The presented ODE method is transformative in that it offers accuracy comparable to the Richards (1931) PDE numerical solution, without the numerical complexity, in a form that is robust, continuous, and suitable for use in large watershed and land-atmosphere simulation models, including regional-scale models of coupled climate and hydrology.
Evidence against dopamine D1/D2 receptor heteromers
Frederick, Aliya L.; Yano, Hideaki; Trifilieff, Pierre; Vishwasrao, Harshad D.; Biezonski, Dominik; Mészáros, József; Sibley, David R.; Kellendonk, Christoph; Sonntag, Kai C.; Graham, Devon L.; Colbran, Roger J.; Stanwood, Gregg D.; Javitch, Jonathan A.
2014-01-01
Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation because their purported potential to manifest signaling and pharmacological properties that differ from the component receptors makes them highly attractive for the development of more selective pharmacological treatments. In particular, dopamine D1 and D2 receptors have been proposed to form hetero-oligomers that couple to Gαq proteins, and SKF83959 has been proposed to act as a biased agonist that selectively engages these receptor complexes to activate Gαq and thus phospholipase C. D1/D2 heteromers have been proposed as relevant to the pathophysiology and treatment of depression and schizophrenia. We used in vitro bioluminescence resonance energy transfer (BRET), ex vivo analyses of receptor localization and proximity in brain slices, and behavioral assays in mice to characterize signaling from these putative dimers/oligomers. We were unable to detect Gαq or Gα11 protein coupling to homomers or heteromers of D1 or D2 receptors using a variety of biosensors. SKF83959-induced locomotor and grooming behaviors were eliminated in D1 receptor knockout mice, verifying a key role for D1-like receptor activation. In contrast, SKF83959-induced motor responses were intact in D2 receptor and Gαq knockout mice, as well as in knock-in mice expressing a mutant Ala286-CaMKIIα, that cannot autophosphorylate to become active. Moreover, we found that in the shell of the nucleus accumbens, even in neurons in which D1 and D2 receptor promoters are both active, the receptor proteins are segregated and do not form complexes. These data are not compatible with SKF83959 signaling through Gαq or through a D1–D2 heteromer and challenge the existence of such a signaling complex in the adult animals that we used for our studies. PMID:25560761
Fast Optimal Load Balancing Algorithms for 1D Partitioning
Pinar, Ali; Aykanat, Cevdet
2002-12-09
One-dimensional decomposition of nonuniform workload arrays for optimal load balancing is investigated. The problem has been studied in the literature as ''chains-on-chains partitioning'' problem. Despite extensive research efforts, heuristics are still used in parallel computing community with the ''hope'' of good decompositions and the ''myth'' of exact algorithms being hard to implement and not runtime efficient. The main objective of this paper is to show that using exact algorithms instead of heuristics yields significant load balance improvements with negligible increase in preprocessing time. We provide detailed pseudocodes of our algorithms so that our results can be easily reproduced. We start with a review of literature on chains-on-chains partitioning problem. We propose improvements on these algorithms as well as efficient implementation tips. We also introduce novel algorithms, which are asymptotically and runtime efficient. We experimented with data sets from two different applications: Sparse matrix computations and Direct volume rendering. Experiments showed that the proposed algorithms are 100 times faster than a single sparse-matrix vector multiplication for 64-way decompositions on average. Experiments also verify that load balance can be significantly improved by using exact algorithms instead of heuristics. These two findings show that exact algorithms with efficient implementations discussed in this paper can effectively replace heuristics.
SWAN-PPL, Fusion Reactor 1-D Particle Transport Optimization
1 - Description of problem or function: Given the material density profiles which describe a one-dimensional reference system with a neutron source, SWAN will calculate, and optionally implement, density changes so as to optimize a single functional parameter of the system. 2 - Method of solution: The one-dimensional discrete-ordinate transport code ANISN is used to calculate flux and adjoint distributions for specified sources. The code SWIF calculates first-order estimates of the effect of material density changes on a goal functional, and from these evaluates effectiveness functions for the substitution of one material for another. Density distribution changes are then calculated which would optimize the goal functional, optionally subject to a constraint of holding another functional constant (to first order). 3 - Restrictions on the complexity of the problem: SWAN is not designed to analyze critical systems; it assumes that there is a fixed source, as in shielding or fusion reactor applications. Otherwise it is compatible with ANISN. All arrays are variably-dimensioned, so that there are no restrictions on individual dimensions
PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms.
Wu, Bo; Guo, Bo-Min; Kang, Jie; Deng, Xian-Zhao; Fan, You-Ben; Zhang, Xiao-Ping; Ai, Kai-Xing
2016-03-01
Protein phosphatase, Mg(2+)/Mn(2+) dependent, 1D (PPM1D) is emerging as an oncogene by virtue of its negative control on several tumor suppressor pathways. However, the clinical significance of PPM1D in pancreatic cancer (PC) has not been defined. In this study, we determined PPM1D expression in human PC tissues and cell lines and their irrespective noncancerous controls. We subsequently investigated the functional role of PPM1D in the migration, invasion, and apoptosis of MIA PaCa-2 and PANC-1 PC cells in vitro and explored the signaling pathways involved. Furthermore, we examined the role of PPM1D in PC tumorigenesis in vivo. Our results showed that PPM1D is overexpressed in human PC tissues and cell lines and significantly correlated with tumor growth and metastasis. PPM1D promotes PC cell migration and invasion via potentiation of the Wnt/β-catenin pathway through downregulation of apoptosis-stimulating of p53 protein 2 (ASPP2). In contrast to PPM1D, our results showed that ASPP2 is downregulated in PC tissues. Additionally, PPM1D suppresses PC cell apoptosis via inhibition of the p38 MAPK/p53 pathway through both dephosphorylation of p38 MAPK and downregulation of ASPP2. Furthermore, PPM1D promotes PC tumor growth in vivo. Our results demonstrated that PPM1D is an oncogene in PC. PMID:26714478
Treebak, Jonas Thue; Pehmøller, Christian; Kristensen, Jonas Møller;
2014-01-01
We investigated the phosphorylation signatures of two Rab GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired experimental design. Eight healthy male volunteers...... TBC1D4 in response to physiological stimuli in human skeletal muscle and support the idea that Akt and AMPK are upstream kinases. TBC1D1 phosphorylation signatures were comparable between in vitro contracted mouse skeletal muscle and exercised human muscle, and we show that AMPK was regulating...... phosphorylation of these sites in mouse muscle. Contraction and exercise elicited a different phosphorylation pattern of TBC1D4 in mouse compared with human muscle, and although different circumstances in our experimental setup may contribute to this difference, the observation exemplifies that transferring...
Yashchuk, Valeriy V.; McKinney, Wayne R.; Takacs, Peter Z.
2008-05-19
We suggest and describe the use of a binary pseudo-random grating as a standard test surface for calibration of the modulation transfer function of microscopes. Results from calibration of a MicromapTM-570 interferometric microscope are presented.
TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
Toyoda, Taro; Yu, Haiyan; Fujii, Nobuharu; Hirshman, Michael F.; An, Ding Jeff; Goodyear, Laurie Joy; Taylor, Eric B.
2010-01-01
OBJECTIVE: TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study was to determine whether TBC1D1 regulates glucose transport in skeletal muscle. RESEARCH DESIGN AND M...
Grid Cell Responses in 1D Environments Assessed as Slices through a 2D Lattice.
Yoon, KiJung; Lewallen, Sam; Kinkhabwala, Amina A; Tank, David W; Fiete, Ila R
2016-03-01
Grid cells, defined by their striking periodic spatial responses in open 2D arenas, appear to respond differently on 1D tracks: the multiple response fields are not periodically arranged, peak amplitudes vary across fields, and the mean spacing between fields is larger than in 2D environments. We ask whether such 1D responses are consistent with the system's 2D dynamics. Combining analytical and numerical methods, we show that the 1D responses of grid cells with stable 1D fields are consistent with a linear slice through a 2D triangular lattice. Further, the 1D responses of comodular cells are well described by parallel slices, and the offsets in the starting points of the 1D slices can predict the measured 2D relative spatial phase between the cells. From these results, we conclude that the 2D dynamics of these cells is preserved in 1D, suggesting a common computation during both types of navigation behavior. PMID:26898777
1D non-uniform dose delivery by a single dynamic absorber
A new technique for 1D non-uniform dose delivery has been recently proposed, using a single computer-controlled dynamic absorber, which is driven within the beam during irradiation. Analytical-iterative and convolution algorithms have been developed in order to optimize the movement of the absorber in creating wished beam modulations. The technique has been demonstrated to be suitable for many applications in the fields of dynamic wedging, tissue-deficit compensation and, in some cases, conformal therapy by non-uniform dose delivery. A first non-focused prototype has been shown to be able to reproduce a number of modulated beams with an acceptable accuracy (Phys.Med. Biol. 40: 221-240, 1995). A new focused prototype has been carried out at our Institute and it is under investigation: preliminary tests (by diodes array and film dosimetry) confirm the wide possibilities of clinical application. The apparatus, which can be inserted in the tray holder of our Clinac Varian 6/100, is connected through a mechanical transmission system to a computer where absorber's speed profiles (corresponding to wished fluence profiles) are stored. The operator can recall the wished profile and move the absorber in the due way, when the irradiation starts. The single-absorber dynamic modulation technique cannot modulate the beam fluence in any way one wishes, due to the physical constraint that the absorber can stay in the irradiation field for a time not larger than the total irradiation time: however it can create a large number of dynamically modulated beams clinically interesting. For this reason it should be considered as a valid 'low-cost' technique for dynamic beam modulation (also on Linacs which do not have complex computer-controlled options for non-uniform dose delivery such as dynamic collimators and multi leaves)
Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.
Kountz, Timothy S; Lee, Kyung-Soon; Aggarwal-Howarth, Stacey; Curran, Elizabeth; Park, Ji-Min; Harris, Dorathy-Ann; Stewart, Aaron; Hendrickson, Joseph; Camp, Nathan D; Wolf-Yadlin, Alejandro; Wang, Edith H; Scott, John D; Hague, Chris
2016-08-26
The α1D-adrenergic receptor (ADRA1D) is a key regulator of cardiovascular, prostate, and central nervous system functions. This clinically relevant G protein-coupled receptor has proven difficult to study, as it must form an obligate modular homodimer containing the PDZ proteins scribble and syntrophin or become retained in the endoplasmic reticulum as non-functional protein. We previously determined that targeted removal of the N-terminal (NT) 79 amino acids facilitates ADRA1D plasma membrane expression and agonist-stimulated functional responses. However, whether such an event occurs in physiological contexts was unknown. Herein, we report the ADRA1D is subjected to innate NT processing in cultured human cells. SNAP near-infrared imaging and tandem-affinity purification revealed the ADRA1D is expressed as both full-length and NT truncated forms in multiple human cell lines. Serial truncation mapping identified the cleavage site as Leu(90)/Val(91) in the 95-amino acid ADRA1D NT domain, suggesting human cells express a Δ1-91 ADRA1D species. Tandem-affinity purification MS/MS and co-immunoprecipitation analysis indicate NT processing of ADRA1D is not required to form scribble-syntrophin macromolecular complexes. Yet, label-free dynamic mass redistribution signaling assays demonstrate that Δ1-91 ADRA1D agonist responses were greater than WT ADRA1D. Mutagenesis of the cleavage site nullified the processing event, resulting in ADRA1D agonist responses less than the WT receptor. Thus, we propose that processing of the ADRA1D NT domain is a physiological mechanism employed by cells to generate a functional ADRA1D isoform with optimal pharmacodynamic properties. PMID:27382054
Off-chip beam steering with a one-dimensional optical phased array on silicon-on-insulator
Van Acoleyen, Karel; Bogaerts, Wim; Jágerská, Jana; Le Thomas, Nicolas; Houdré, Romuald; Baets, Roel
2009-01-01
Optical phased arrays are versatile components enabling rapid and precise beam steering. An integrated approach is followed in which a 1D optical phased array is fabricated on silicon-on-insulator. The optical phased array consists of 16 parallel grating couplers spaced 2 mu m apart. Steering in one direction is done thermo-optically by means of a titanium electrode on top of the structure using the phased array principle, while steering in the other direction is accomplished by wavelength tu...
关于图的L(d1,d2)-标号问题%The L(d1, d2)-Labeling Problem on Graphs
邵振东; 刘家壮
2006-01-01
The L(2, 1)-labeling is formulated from the frequency assignment problem. We study the L(d1, d2)- labeling which is a generalization of the L(2, 1)-labeling. Vertex 2-coloring, 2-chromatic number and other related concepts are firstly defined, and the upper bound for 2-chromatic number is given; a very general relationship between λd1 ,d2 (G) and minimum degree δ(G) and maximum degree △(G) is then derived; finally, the upper bounds of L(d1, d2)-labelings of general and planar graphs are given.%图的L(2,1)-标号问题是由频率分配问题归结而来,本文研究作为L(2,1)-标号问题的推广的L(d1,d2)-标号问题.首先定义了顶点2-着色,2-色数及其它有关概念,给出了2-色数的上界.然后得出了λd1,d2(G)与δ(G)和△(G)的一般关系.最后得出了一般图与平面图的λd1,d2(G)的上界.
A Proposal for Realizing an Array of Bose-Einstein Condensates
印建平; 高伟建; 胡建军
2002-01-01
We propose one-dimensional (1D) and two-dimensional (2D) arrays of magnetic surface microtraps for coldalkali atoms using some arrays of current-carrying wires and we calculate the spatial distributions of magneticfields from the 1D and 2D arrays of current-carrying wires. The field gradients and curvatures from a singlemagnetic microtrap are analysed, and some interesting and periodic magnetic-well microstructures are found.The result shows that a magnetic-field gradient greater than 2.4 × 105 G/cm and a field curvature greater than4.05 × 108 G/cm2 can be generated in our array of magnetic microtraps, which can be used to realize the 1Dand 2D arrays of Bose-Einstein condensations (or 1D and 2D arrays of Bose clusters) by rf-induced evaporativecooling, and then to form 1D and 2D atomic magnetic lattices, even to prepare 1D and 2D photonic crystals.
Exercise increases TBC1D1 phosphorylation in human skeletal muscle
Jessen, Niels; An, Ding; Lihn, Aina S.; Nygren, Jonas; Hirshman, Michael F.; Thorell, Anders; Goodyear, Laurie J.
2011-01-01
Exercise and weight loss are cornerstones in the treatment and prevention of type 2 diabetes, and both interventions function to increase insulin sensitivity and glucose uptake into skeletal muscle. Studies in rodents demonstrate that the underlying mechanism for glucose uptake in muscle involves site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 (TBC1D4) and TBC1D1. Multiple kinases, including Akt and AMPK, phosphorylate TBC1D1 and AS160 on distinct residues, regulatin...
1D engine simulation of a turbocharged SI engine with CFD computation on components
Renberg, Ulrica
2008-01-01
Techniques that can increase the SI- engine efficiency while keeping the emissions very low is to reduce the engine displacement volume combined with a charging system. Advanced systems are needed for an effective boosting of the engine and today 1D engine simulation tools are often used for their optimization. This thesis concerns 1D engine simulation of a turbocharged SI engine and the introduction of CFD computations on components as a way to assess inaccuracies in the 1D model. 1D engine ...
Faltermann, Susanne; Prétôt, René; Pernthaler, Jakob; Fent, Karl
2016-02-01
Microcystin-LR (MC-LR) and nodularin are hepatotoxins produced by several cyanobacterial species. Their toxicity is based on active cellular uptake and subsequent inhibition of protein phosphatases PP1/2A, leading to hyperphosphorylation and cell death. To date, uptake of MC-LR and nodularin in fish is poorly understood. Here, we investigated the role of the organic anion transporting polypeptide Oatp1d1 in zebrafish (drOatp1d1, Slco1d1) in cellular uptake in zebrafish. We stably transfected CHO and HEK293 cell lines expressing drOatp1d1. In both transfectants, uptake of MC-LR and nodularin was demonstrated by competitive inhibition of uptake with fluorescent substrate lucifer yellow. Direct uptake of MC-LR was demonstrated by immunostaining, and indirectly by the high cytotoxicity in stable transfectants. By means of a synthesized fluorescent labeled MC-LR derivative, direct uptake was further confirmed in HEK293 cells expressing drOatp1d1. Additionally, uptake and toxicity was investigated in the permanent zebrafish liver cell line ZFL. These cells had only a low relative abundance of drOatp1d1, drOatp2b1 and drOatp1f transcripts, which correlated with the lack of MC-LR induced cytotoxicity and transcriptional changes of genes indicative of endoplasmic reticulum stress, a known effect of this toxin. Our study demonstrates that drOatp1d1 functions as an uptake transporter for both MC-LR and nodularin in zebrafish. PMID:26769064
Ozaki, N.; Lappalainen, J.; Linnoila, M. [National Institute on Alcohol Abuse and Alcoholism, Rockville, MD (United States)] [and others
1995-04-24
Serotonin (5-HT){sub ID} receptors are 5-HT release-regulating autoreceptors in the human brain. Abnormalities in brain 5-HT function have been hypothesized in the pathophysiology of various psychiatric disorders, including obsessive-compulsive disorder, autism, mood disorders, eating disorders, impulsive violent behavior, and alcoholism. Thus, mutations occurring in 5-HT autoreceptors may cause or increase the vulnerability to any of these conditions. 5-HT{sub 1D{alpha}} and 5-HT{sub 1D{Beta}} subtypes have been previously localized to chromosomes 1p36.3-p34.3 and 6q13, respectively, using rodent-human hybrids and in situ localization. In this communication, we report the detection of a 5-HT{sub 1D{alpha}} receptor gene polymorphism by single strand conformation polymorphism (SSCP) analysis of the coding sequence. The polymorphism was used for fine scale linkage mapping of 5-HT{sub 1D{alpha}} on chromosome 1. This polymorphism should also be useful for linkage studies in populations and in families. Our analysis also demonstrates that functionally significant coding sequence variants of the 5-HT{sub 1D{alpha}} are probably not abundant either among alcoholics or in the general population. 14 refs., 1 fig., 1 tab.
Mandre, Shreyas
2016-01-01
Wind and hydrokinetic turbine array performance suffers because the wakes of upstream turbines diminish flow to downstream turbines. Here we analyze systematic deflection of the wakes to direct unimpeded flow onto the downstream turbines and increase the area power density. We examine the case of an abstract 1D turbine-deflector array aligned parallel to a 2D free stream flow, in which case the array presents negligible frontal area to the flow without deflection. Using the framework of inviscid fluid dynamics, the flow manipulation is decomposed into flow deflection due to bound vorticity in the array, and energy extraction resulting from free vorticity shed by the array. While this general framework is agnostic to the technological details, it captures the geometry of a vertical fence of turbines and deflectors along the centerline of a river, minimizing the array footprint. We find a localized array can direct significant kinetic energy through itself, while having a minimal impact on array efficiency; the...
Identification of RAPD Marker for Chromosome 1D of Common Wheat
Imtiaz Ahmad Khan
2010-04-01
Full Text Available Development of genetically compensating nullisomic-tetrasomic and ditelosomic lines of commonwheat (Triticum aestivum L. have been widely used to construct high density genetic maps of homoeologouswheat chromosomes. During present research, easier, cheaper and quicker procedure of Polymerase ChainReaction (PCR was used to map Randomly Amplified Polymorphic DNA primers on chromosome 1D ofcommon wheat. Genomic DNA was isolated from two genetic stocks of wheat cultivar Chinese Spring viz;NT-1D1B and NT-2A2B. PCR were conducted using RAPD primers GLC-07 and GLC-11. RAPD primerGLC-11 amplified a polymorphic allele of approximately 500 bp, which was present in NT-2A2B (used aspositive control but was absent in NT-1D1B indicating that the locus is present on chromosome 1D of commonwheat. Hence this marker (GLC-11 can reliably be used to keep track of chromosome 1D of hexaploid wheat.
Wee, W H; Pendry, J B [Condensed Matter Theory Group Department of Physics Imperial College London London SW7 2AZ (United Kingdom)], E-mail: w.wee07@imperial.ac.uk
2010-03-15
For a long time phase arrays have been used in a variety of wave transmission applications because of their simplicity and versatility. Conventionally there is a trade-off between the compactness of a phase array and its directivity. In this paper we demonstrate how by embedding a normal phase array within a superlens (made of negative refractive index material) we can overcome this constraint and create compact phase arrays with a virtual extent much larger than the physical size of the array. In this paper we also briefly discuss the apparent unphysical field divergences in superlenses and how to resolve this issue.
For a long time phase arrays have been used in a variety of wave transmission applications because of their simplicity and versatility. Conventionally there is a trade-off between the compactness of a phase array and its directivity. In this paper we demonstrate how by embedding a normal phase array within a superlens (made of negative refractive index material) we can overcome this constraint and create compact phase arrays with a virtual extent much larger than the physical size of the array. In this paper we also briefly discuss the apparent unphysical field divergences in superlenses and how to resolve this issue.
A fully relativistic Dirac-Fock method with Breit and QED corrections has been employed to study energy levels and oscillator strengths for the ns(n-1)d 1D-ns21S transitions of the alkaline earth atoms. In calculation, the authors consider significant Breit and QED corrections, the results are in good agreements with recent experimental data and other theoretical values. The results show that it is feasible to obtain the highly Rybderg states of the alkaline earth atoms, especially the autoionization states, by use of quadrupole transitions as an intermediate resonance
Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids
Sandusky, Peter [Eckerd College, Department of Chemistry (United States); Appiah-Amponsah, Emmanuel; Raftery, Daniel, E-mail: raftery@purdue.edu [Purdue University, Department of Chemistry (United States)
2011-04-15
One dimensional selective TOCSY experiments have been shown to be advantageous in providing improved data inputs for principle component analysis (PCA) (Sandusky and Raftery 2005a, b). Better subpopulation cluster resolution in the observed scores plots results from the ability to isolate metabolite signals of interest via the TOCSY based filtering approach. This report reexamines the quantitative aspects of this approach, first by optimizing the 1D TOCSY experiment as it relates to the measurement of biofluid constituent concentrations, and second by comparing the integration of 1D TOCSY read peaks to the bucket integration of 1D proton NMR spectra in terms of precision and accuracy. This comparison indicates that, because of the extensive peak overlap that occurs in the 1D proton NMR spectra of biofluid samples, bucket integrals are often far less accurate as measures of individual constituent concentrations than 1D TOCSY read peaks. Even spectral fitting approaches have proven difficult in the analysis of significantly overlapped spectral regions. Measurements of endogenous taurine made over a sample population of human urine demonstrates that, due to background signals from other constituents, bucket integrals of 1D proton spectra routinely overestimate the taurine concentrations and distort its variation over the sample population. As a result, PCA calculations performed using data matrices incorporating 1D TOCSY determined taurine concentrations produce better scores plot subpopulation cluster resolution.
rasdaman Array Database: current status
Merticariu, George; Toader, Alexandru
2015-04-01
rasdaman (Raster Data Manager) is a Free Open Source Array Database Management System which provides functionality for storing and processing massive amounts of raster data in the form of multidimensional arrays. The user can access, process and delete the data using SQL. The key features of rasdaman are: flexibility (datasets of any dimensionality can be processed with the help of SQL queries), scalability (rasdaman's distributed architecture enables it to seamlessly run on cloud infrastructures while offering an increase in performance with the increase of computation resources), performance (real-time access, processing, mixing and filtering of arrays of any dimensionality) and reliability (legacy communication protocol replaced with a new one based on cutting edge technology - Google Protocol Buffers and ZeroMQ). Among the data with which the system works, we can count 1D time series, 2D remote sensing imagery, 3D image time series, 3D geophysical data, and 4D atmospheric and climate data. Most of these representations cannot be stored only in the form of raw arrays, as the location information of the contents is also important for having a correct geoposition on Earth. This is defined by ISO 19123 as coverage data. rasdaman provides coverage data support through the Petascope service. Extensions were added on top of rasdaman in order to provide support for the Geoscience community. The following OGC standards are currently supported: Web Map Service (WMS), Web Coverage Service (WCS), and Web Coverage Processing Service (WCPS). The Web Map Service is an extension which provides zoom and pan navigation over images provided by a map server. Starting with version 9.1, rasdaman supports WMS version 1.3. The Web Coverage Service provides capabilities for downloading multi-dimensional coverage data. Support is also provided for several extensions of this service: Subsetting Extension, Scaling Extension, and, starting with version 9.1, Transaction Extension, which
CD1d and invariant NKT cells at the human maternal–fetal interface
Boyson, Jonathan E.; Rybalov, Basya; Koopman, Louise A.; Exley, Mark; Balk, Steven P.; Racke, Frederick K.; Schatz, Frederick; Masch, Rachel; Wilson, S. Brian; Strominger, Jack L.
2002-01-01
Invariant CD1d-restricted natural killer T (iNKT) cells comprise a small, but significant, immunoregulatory T cell subset. Here, the presence of these cells and their CD1d ligand at the human maternal–fetal interface was investigated. Immunohistochemical staining of human decidua revealed the expression of CD1d on both villous and extravillous trophoblasts, the fetal cells that invade the maternal decidua. Decidual iNKT cells comprised 0.48% of the decidual CD3+ T cell population, a frequency...
Charge Transport in 1-D Nanostructured CdS Dye Sensitized Solar Cell
Charge transport in eosin yellow sensitized CdS 1-D nanostructures is studied. Direct conduction pathway for electron transport in nanowires enhances Voc in CdS nanowires compared to nanorods and nanoparticles. J-V characterization of nanowires results in improved efficiency of 0.184% due to fewer interparticle connections. Increase in Jsc is observed by coating CdS 1-D nanostructures on TiO2 substrate which reduces rate of recombination and photocorrosive nature of CdS photoanodes. Enhancement in efficiency up to 0.501% is achieved for CdS 1-D nanostructures DSSCs on TiO2 substrate.
Non-uniform black strings and the critical dimension in the $1/D$ expansion
Suzuki, Ryotaku; Tanabe, Kentaro
2015-01-01
Non-uniform black strings (NUBS) are studied by the large $D$ effective theory approach. By solving the near-horizon geometry in the $1/D$ expansion, we obtain the effective equation for the deformed horizon up to the next-to-next-to-leading order (NNLO) in $1/D$. We also solve the far-zone geometry by the Newtonian approximation. Matching the near and far zones, the thermodynamic variables are computed in the $1/D$ expansion. As the result, the large $D$ analysis gives a critical dimension $...
Development of a 1D neutron transport code employing the method of characteristics
To investigate the 2D/1D fusion core analysis method, a 1D neutron transport problem solver, PEACH-ID, is developed. It is a code of method of characteristics (MOC), both the usual fiat-source step characteristics (SC) scheme and linear source (LS) approximation scheme are adopted for tracking calculation along the neutron flying trajectory. Exponential function interpolation table and fission source extrapolation are adopted as two major methods to accelerate the computational process. Numerical results demonstrate that PEACH-1D is accurate and efficient, and the proposed LS scheme is able to handle quite larger mesh division and deserves much more application in the MOC codes. (authors)
Optical analogue of relativistic Dirac solitons in binary waveguide arrays
We study analytically and numerically an optical analogue of Dirac solitons in binary waveguide arrays in the presence of Kerr nonlinearity. Pseudo-relativistic soliton solutions of the coupled-mode equations describing dynamics in the array are analytically derived. We demonstrate that with the found soliton solutions, the coupled mode equations can be converted into the nonlinear relativistic 1D Dirac equation. This paves the way for using binary waveguide arrays as a classical simulator of quantum nonlinear effects arising from the Dirac equation, something that is thought to be impossible to achieve in conventional (i.e. linear) quantum field theory. -- Highlights: •An optical analogue of Dirac solitons in nonlinear binary waveguide arrays is suggested. •Analytical solutions to pseudo-relativistic solitons are presented. •A correspondence of optical coupled-mode equations with the nonlinear relativistic Dirac equation is established
Carbon nanotube nanoelectrode arrays
Ren, Zhifeng; Lin, Yuehe; Yantasee, Wassana; Liu, Guodong; Lu, Fang; Tu, Yi
2008-11-18
The present invention relates to microelectode arrays (MEAs), and more particularly to carbon nanotube nanoelectrode arrays (CNT-NEAs) for chemical and biological sensing, and methods of use. A nanoelectrode array includes a carbon nanotube material comprising an array of substantially linear carbon nanotubes each having a proximal end and a distal end, the proximal end of the carbon nanotubes are attached to a catalyst substrate material so as to form the array with a pre-determined site density, wherein the carbon nanotubes are aligned with respect to one another within the array; an electrically insulating layer on the surface of the carbon nanotube material, whereby the distal end of the carbon nanotubes extend beyond the electrically insulating layer; a second adhesive electrically insulating layer on the surface of the electrically insulating layer, whereby the distal end of the carbon nanotubes extend beyond the second adhesive electrically insulating layer; and a metal wire attached to the catalyst substrate material.
Kong, Chen; Lange, Jeffrey J.; Samovski, Dmitri [Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110 (United States); Su, Xiong [Department of Internal Medicine, Center for Human Nutrition Washington University School of Medicine, St. Louis, MO 63110 (United States); Liu, Jialiu [Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110 (United States); Sundaresan, Sinju [Department of Internal Medicine, Center for Human Nutrition Washington University School of Medicine, St. Louis, MO 63110 (United States); Stahl, Philip D., E-mail: pstahl@wustl.edu [Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110 (United States)
2013-05-03
Highlights: •Hominoid-specific oncogene TBC1D3 is targeted to plasma membrane by palmitoylation. •TBC1D3 is palmitoylated on two cysteine residues: 318 and 325. •TBC1D3 palmitoylation governs growth factors-induced TBC1D3 degradation. •Post-translational modifications may regulate oncogenic properties of TBC1D3. -- Abstract: Expression of the hominoid-specific oncoprotein TBC1D3 promotes enhanced cell growth and proliferation by increased activation of signal transduction through several growth factors. Recently we documented the role of CUL7 E3 ligase in growth factors-induced ubiquitination and degradation of TBC1D3. Here we expanded our study to discover additional molecular mechanisms that control TBC1D3 protein turnover. We report that TBC1D3 is palmitoylated on two cysteine residues: 318 and 325. The expression of double palmitoylation mutant TBC1D3:C318/325S resulted in protein mislocalization and enhanced growth factors-induced TBC1D3 degradation. Moreover, ubiquitination of TBC1D3 via CUL7 E3 ligase complex was increased by mutating the palmitoylation sites, suggesting that depalmitoylation of TBC1D3 makes the protein more available for ubiquitination and degradation. The results reported here provide novel insights into the molecular mechanisms that govern TBC1D3 protein degradation. Dysregulation of these mechanisms in vivo could potentially result in aberrant TBC1D3 expression and promote oncogenesis.
Non-uniform black strings and the critical dimension in the $1/D$ expansion
Suzuki, Ryotaku
2015-01-01
Non-uniform black strings (NUBS) are studied by the large $D$ effective theory approach. By solving the near-horizon geometry in the $1/D$ expansion, we obtain the effective equation for the deformed horizon up to the next-to-next-to-leading order (NNLO) in $1/D$. We also solve the far-zone geometry by the Newtonian approximation. Matching the near and far zones, the thermodynamic variables are computed in the $1/D$ expansion. As the result, the large $D$ analysis gives a critical dimension $D_*\\simeq13.5$ at which the translation-symmetry-breaking phase transition changes between first and second order. This value of $D_*$ agrees perfectly, within the precision of the $1/D$ expansion, with the result previously obtained by E. Sorkin through the numerical resolution. We also compare our NNLO results for the thermodynamics of NUBS to earlier numerical calculations, and find good agreement within the expected precision.
Non-uniform black strings and the critical dimension in the 1/D expansion
Suzuki, Ryotaku; Tanabe, Kentaro
2015-10-01
Non-uniform black strings (NUBS) are studied by the large D effective theory approach. By solving the near-horizon geometry in the 1 /D expansion, we obtain the effective equation for the deformed horizon up to the next-to-next-to-leading order (NNLO) in 1 /D. We also solve the far-zone geometry by the Newtonian approximation. Matching the near and far zones, the thermodynamic variables are computed in the 1 /D expansion. As the result, the large D analysis gives a critical dimension D * ≃ 13 .5 at which the translation-symmetry-breaking phase transition changes between first and second order. This value of D * agrees perfectly, within the precision of the 1 /D expansion, with the result previously obtained by E. Sorkin through the numerical resolution. We also compare our NNLO results for the thermodynamics of NUBS to earlier numerical calculations, and find good agreement within the expected precision.
Grinberg, L; Cheever, E; Anor, T; Madsen, J R; Karniadakis, G E
2011-01-01
We compare results from numerical simulations of pulsatile blood flow in two patient-specific intracranial arterial networks using one-dimensional (1D) and three-dimensional (3D) models. Specifically, we focus on the pressure and flowrate distribution at different segments of the network computed by the two models. Results obtained with 1D and 3D models with rigid walls show good agreement in massflow distribution at tens of arterial junctions and also in pressure drop along the arteries. The 3D simulations with the rigid walls predict higher amplitude of the flowrate and pressure temporal oscillations than the 1D simulations with compliant walls at various segments even for small time-variations in the arterial cross-sectional areas. Sensitivity of the flow and pressure with respect to variation in the elasticity parameters is investigated with the 1D model. PMID:20661645
Arrays of microscopic magnetic traps for cold atoms and their applications in atom optics
印建平; 高伟建; 胡建军
2002-01-01
A single microscopic magnetic trap for neutral atoms using planar current-carrying wires was proposed and studiedtheoretically by Weinstein et al. In this paper, we propose three structures of composite current-carrying wires to provide1D, 2D and 3D arrays of microscopic magnetic traps for cold alkali atoms. The spatial distributions of magnetic fieldsgenerated by these structures are calculated and the field gradient and curvature in each single microtrap are analysed.Our study shows that arrays of microscopic magnetic traps can be used to provide 1D, 2D or 3D atomic magneticlattices, and even to realize 1D, 2D and 3D arrays of magneto-optical traps, and so on.
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
Hayashi, Ryo; Tanoue, Kan; Durell, Stewart R; Chatterjee, Deb K; Jenkins, Lisa M Miller; Appella, Daniel H; Appella, Ettore
2011-05-31
PPM1D (PP2Cδ or Wip1) was identified as a wild-type p53-induced Ser/Thr phosphatase that accumulates after DNA damage and classified into the PP2C family. It dephosphorylates and inactivates several proteins critical for cellular stress responses, including p38 MAPK, p53, and ATM. Furthermore, PPM1D is amplified and/or overexpressed in a number of human cancers. Thus, inhibition of its activity could constitute an important new strategy for therapeutic intervention to halt the progression of several different cancers. Previously, we reported the development of a cyclic thioether peptide with low micromolar inhibitory activity toward PPM1D. Here, we describe important improvements in the inhibitory activity of this class of cyclic peptides and also present a binding model based upon the results. We found that specific interaction of an aromatic ring at the X1 position and negative charge at the X5 and X6 positions significantly increased the inhibitory activity of the cyclic peptide, with the optimized molecule having a K(i) of 110 nM. To the best of our knowledge, this represents the highest inhibitory activity reported for an inhibitor of PPM1D. We further developed an inhibitor selective for PPM1D over PPM1A with a K(i) of 2.9 μM. Optimization of the cyclic peptide and mutagenesis experiments suggest that a highly basic loop unique to PPM1D is related to substrate specificity. We propose a new model for the catalytic site of PPM1D and inhibition by the cyclic peptides that will be useful both for the subsequent design of PPM1D inhibitors and for identification of new substrates. PMID:21528848
Momentum Conservation Implies Anomalous Energy Transport in 1D Classical Lattices
Under quite general conditions, we prove that for classical many-body lattice Hamiltonians in one dimension (1D) total momentum conservation implies anomalous conductivity in the sense of the divergence of the Kubo expression for the coefficient of thermal conductivity, κ . Our results provide rigorous confirmation and explanation of many of the existing ''surprising'' numerical studies of anomalous conductivity in 1D classical lattices, including the celebrated Fermi-Pasta-Ulam problem. (c) 2000 The American Physical Society
Momentum conservation implies anomalous energy transport in 1d classical lattices
Prosen, T; Prosen, Tomaz; Campbell, David K.
2000-01-01
Under quite general conditions, we prove that for classical many-body lattice Hamiltonians in one dimension (1D) total momentum conservation implies anomalous conductivity in the sense of the divergence of the Kubo expression for the coefficient of thermal conductivity, $\\kappa$. Our results provide rigorous confirmation and explanation of many of the existing ``surprising'' numerical studies of anomalous conductivity in 1D classical lattices, including the celebrated Fermi-Pasta-Ulam problem.
User's manual of the REFLA-1D/MODE4 reflood thermo-hydrodynamic analysis code
REFLA-1D/MODE4 code has been developed by incorporating local power effect model and fuel temperature profile effect model into REFLA-1D/MODE3 code. This code can calculate the temperature transient of local rod by considering radial power profile effect in core and simulate the thermal characteristics of the nuclear fuel rod. This manual describes the outline of incorporated models, modification of the code with incorporating models and provides application information required to utilize the code. (author)
1D model for the dynamics and expansion of elongated Bose-Einstein condensates
Massignan, Pietro; Modugno, Michele
2002-01-01
We present a 1D effective model for the evolution of a cigar-shaped Bose-Einstein condensate in time dependent potentials whose radial component is harmonic. We apply this model to investigate the dynamics and expansion of condensates in 1D optical lattices, by comparing our predictions with recent experimental data and theoretical results. We also discuss negative-mass effects which could be probed during the expansion of a condensate moving in an optical lattice.
Kayserili Karabey, Hülya; Schmidts, Miriam; Hou, Yuqing; Cortes, Claudio R.; Mans, Dorus A.; Huber, Celine; Boldt, Karsten; Patel, Mitali; van Reeuwijk, Jeroen; Plaza, Jean-Marc; van Beersum, Sylvia E. C.; Yap, Zhi Min; Letteboer, Stef J. F.; Taylor, S. Paige; Herridge, Warren; Johnson, Colin A.; Scambler, Peter J.; Ueffing, Marius; Krakow, Deborah; King, Stephen M.; Beales, Philip L.; Al-Gazali, Lihadh; Wicking, Carol; Cormier-Daire, Valerie; Roepman, Ronald; Mitchison, Hannah M.; Witman, George B.
2015-01-01
The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. W...
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Olszak, Torsten; Neves, Joana F; Dowds, C Marie; Baker, Kristi; Glickman, Jonathan; Davidson, Nicholas O; Lin, Chyuan-Sheng; Jobin, Christian; Brand, Stephan; Sotlar, Karl; Wada, Koichiro; Katayama, Kazufumi; Nakajima, Atsushi; Mizuguchi, Hiroyuki; Kawasaki, Kunito; Nagata, Kazuhiro; Müller, Werner; Snapper, Scott B; Schreiber, Stefan; Kaser, Arthur; Zeissig, Sebastian; Blumberg, Richard S
2014-05-22
The mechanisms by which mucosal homeostasis is maintained are of central importance to inflammatory bowel disease. Critical to these processes is the intestinal epithelial cell (IEC), which regulates immune responses at the interface between the commensal microbiota and the host. CD1d presents self and microbial lipid antigens to natural killer T (NKT) cells, which are involved in the pathogenesis of colitis in animal models and human inflammatory bowel disease. As CD1d crosslinking on model IECs results in the production of the important regulatory cytokine interleukin (IL)-10 (ref. 9), decreased epithelial CD1d expression--as observed in inflammatory bowel disease--may contribute substantially to intestinal inflammation. Here we show in mice that whereas bone-marrow-derived CD1d signals contribute to NKT-cell-mediated intestinal inflammation, engagement of epithelial CD1d elicits protective effects through the activation of STAT3 and STAT3-dependent transcription of IL-10, heat shock protein 110 (HSP110; also known as HSP105), and CD1d itself. All of these epithelial elements are critically involved in controlling CD1d-mediated intestinal inflammation. This is demonstrated by severe NKT-cell-mediated colitis upon IEC-specific deletion of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well as deletion of HSP110 in the radioresistant compartment. Our studies thus uncover a novel pathway of IEC-dependent regulation of mucosal homeostasis and highlight a critical role of IL-10 in the intestinal epithelium, with broad implications for diseases such as inflammatory bowel disease. PMID:24717441
Protective mucosal immunity mediated by epithelial CD1d and IL-10
Olszak, Torsten; Neves, Joana F.; Dowds, C. Marie; Baker, Kristi; Glickman, Jonathan; Davidson, Nicholas O; Lin, Chyuan-Sheng; Jobin, Christian; Brand, Stephan; Sotlar, Karl; Wada, Koichiro; Katayama, Kazufumi; Nakajima, Atsushi; Mizuguchi, Hiroyuki; Kawasaki, Kunito
2014-01-01
The mechanisms by which mucosal homeostasis is maintained are of central importance to inflammatory bowel disease. Critical to these processes is the intestinal epithelial cell (IEC), which regulates immune responses at the interface between the commensal microbiota and the host1,2. CD1d presents self and microbial lipid antigens to natural killer T (NKT) cells, which are involved in the pathogenesis of colitis in animal models and human inflammatory bowel disease3–8. As CD1d crosslinking on ...
Simple model of the density of states in 1D photonic crystal
Rudziński, Adam; Tyszka-Zawadzka, Anna; Szczepański, Paweł
2010-01-01
In this paper, we present a simple, yet versatile, analytical model of one-dimensional photonic crystal (1D PC). In our theoretical model, we take into account direction of propagation and therefore do not neglect anisotropic nature of photonic crystals. We derive analytical expressions for mode spectrum and density of states in 1D photonic crystal. With those formulas, we obtain mode spectrum characteristics, which depict formation of photonic band gap and reveal properties of photonic cryst...
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Dynamics of reactions O((1)D)+C(6)H(6) and C(6)D(6).
Chen, Hui-Fen; Liang, Chi-Wei; Lin, Jim J; Lee, Yuan-Pern; Ogilvie, J F; Xu, Z F; Lin, M C
2008-11-01
The reaction between O((1)D) and C(6)H(6) (or C(6)D(6)) was investigated with crossed-molecular-beam reactive scattering and time-resolved Fourier-transform infrared spectroscopy. From the crossed-molecular-beam experiments, four product channels were identified. The major channel is the formation of three fragments CO+C(5)H(5)+H; the channels for formation of C(5)H(6)+CO and C(6)H(5)O+H from O((1)D)+C(6)H(6) and OD+C(6)D(5) from O((1)D)+C(6)D(6) are minor. The angular distributions for the formation of CO and H indicate a mechanism involving a long-lived collision complex. Rotationally resolved infrared emission spectra of CO (1ratio of [CO]/[OH]=2.1+/-0.4 for O((1)D)+C(6)H(6) and [CO]/[OD]>2.9 for O((1)D)+C(6)D(6) is consistent with the expectation for an abstraction reaction. The mechanism of the reaction may be understood from considering the energetics of the intermediate species and transition states calculated at the G2M(CC5) level of theory for the O((1)D)+C(6)H(6) reaction. The experimentally observed branching ratios and deuterium isotope effect are consistent with those predicted from calculations. PMID:19045343
Microplasma array serving as photonic crystals and plasmon chains
An array of microplasmas with sizes ranging from a millimeter to a micrometer, has potential for novel and promising electromagnetic-wave media, especially when the wave frequency is below the electron plasma frequency. Photonic crystals or band-gap materials composed of microplasmas have unique properties arising from their loss term, and they can become band-pass filters instead of the band-stop filters usually observed in photonic crystals of dielectrics. Such behavior is well understood using the dispersion relation in a three-dimensional space of frequency and complex wavenumber with real and imaginary parts. Another functional array is a simple one-dimensional (1D) array; it can conduct microwaves for a wide frequency range below the electron plasma frequency. The propagating modes are similar to the coupling of localized surface plasmon polaritons observed along a metallic nanoparticle chain in the photon range; however a 1D microplasma array features differ from those of a metallic sphere array, leading to a dynamic wide-band waveguide. (author)
Shot noise in frustrated single-electron arrays
Kaplan, Daniel M.; Sverdlov, Victor A.; Likharev, Konstantin K.
2003-01-01
We have carried out numerical simulations of shot noise in 2D arrays of single-electron islands with random background charges. The results show that in contrast with the 1D arrays, at low currents the current noise is strongly colored, and its spectral density levels off at very low frequencies. The Fano factor may be much larger than unity, due to the remnants of single-electron/hole avalanches. However, even very small thermal fluctuations reduce the Fano factor below 1 for almost any bias.
Riedl, C; Akopov, Z; Amarian, M; Ammosov, V V; Andrus, A; Aschenauer, E C; Augustyniak, W; Avakian, R; Avetisian, A; Avetissian, E; Bailey, P; Baturin, V; Baumgarten, C; Beckmann, M; Belostotskii, S; Bernreuther, S; Bianchi, N; Blok, H P; Böttcher, Helmut B; Borisov, A; Bouwhuis, M; Brack, J; Brüll, A; Bryzgalov, V V; Capitani, G P; Chiang, H C; Ciullo, G; Contalbrigo, M; Dalpiaz, P F; De Leo, R; De Nardo, L; De Sanctis, E; Devitsin, E G; Di Nezza, P; Düren, M; Ehrenfried, M; Elalaoui-Moulay, A; Elbakian, G M; Ellinghaus, F; Elschenbroich, U; Ely, J; Fabbri, R; Fantoni, A; Feshchenko, A; Felawka, L; Fox, B; Franz, J; Frullani, S; Gärber, Y; Gapienko, G; Gapienko, V; Garibaldi, F; Garrow, K; Garutti, E; Gaskell, D; Gavrilov, G E; Karibian, V; Graw, G; Grebenyuk, O; Greeniaus, L G; Hafidi, K; Hartig, M; Hasch, D; Heesbeen, D; Henoch, M; Hertenberger, R; Hesselink, W H A; Hillenbrand, A; Hoek, M; Holler, Y; Hommez, B; Iarygin, G; Ivanilov, A; Izotov, A; Jackson, H E; Jgoun, A; Kaiser, R; Kinney, E; Kiselev, A; Königsmann, K C; Kopytin, M; Korotkov, V A; Kozlov, V; Krauss, B; Krivokhizhin, V G; Lagamba, L; Lapikas, L; Laziev, A; Lenisa, P; Liebing, P; Lindemann, T; Lipka, K; Lorenzon, W; Lü, J; Maiheu, B; Makins, N C R; Marianski, B; Marukyan, H O; Masoli, F; Mexner, V; Meyners, N; Miklukho, O; Miller, C A; Miyachi, Y; Muccifora, V; Nagaitsev, A; Nappi, E; Naryshkin, Yu; Nass, A; Negodaev, M A; Nowak, Wolf-Dieter; Oganessyan, K; Ohsuga, H; Orlandi, G; Pickert, N; Potashov, S Yu; Potterveld, D H; Raithel, M; Reggiani, D; Reimer, P E; Reischl, A; Reolon, A R; Rith, K; Airapetian, A; Rosner, G; Rostomyan, A; Rubacek, L; Ryckbosch, D; Salomatin, Yu I; Sanjiev, I; Savin, I; Scarlett, C; Schäfer, A; Schill, C; Schnell, G; Schüler, K P; Schwind, A; Seele, J; Seidl, R; Seitz, B; Shanidze, R G; Shearer, C; Shibata, T A; Shutov, V B; Simani, M C; Sinram, K; Stancari, M D; Statera, M; Steffens, E; Steijger, J J M; Stewart, J; Stösslein, U; Tait, P; Tanaka, H; Taroian, S P; Tchuiko, B; Terkulov, A R; Tkabladze, A V; Trzcinski, A; Tytgat, M; Vandenbroucke, A; Van der Nat, P B; van der Steenhoven, G; Vetterli, Martin C; Vikhrov, V; Vincter, M G; Visser, J; Vogel, C; Vogt, M; Volmer, J; Weiskopf, C; Wendland, J; Wilbert, J; Ybeles-Smit, G V; Yen, S; Zihlmann, B; Zohrabyan, H G; Zupranski, P; Riedl, Caroline
2005-01-01
Final HERMES results on the proton, deuteron and neutron structure function g1 are presented in the kinematic range 0.0021
Bi, Zhen; BenTov, Yoni; Xu, Cenke
2016-01-01
Motivated by recent studies of symmetry protected topological (SPT) phases, we explore the possible gapless quantum disordered phases in the $(2+1)d$ nonlinear sigma model defined on the Grassmannian manifold $\\frac{U(N)}{U(n)\\times U(N - n)}$ with a Wess-Zumino-Witten (WZW) term at level $k$, which is the effective low energy field theory of the boundary of certain $(3+1)d$ SPT states. With $k = 0$, this model has a well-controlled large-$N$ limit, $i.e.$ its renormalization group equations can be computed exactly with large-$N$. However, with the WZW term, the large-$N$ and large-$k$ limit alone is not sufficient for a reliable study of the nature of the quantum disordered phase. We demonstrate that at least for $n = 1$, through a combined large-$N$, large-$k$ and $3-\\epsilon$ generalization, a stable fixed point in the quantum disordered phase can be reliably located, which corresponds to a $(2+1)d$ strongly interacting conformal field theory. Extension of our method to $n > 1$ will also be discussed.
Andersen, Gary L.; DeSantis, Todd D.
2014-07-08
The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.
Okandan, Murat (Edgewood, NM); Wessendorf, Kurt O. (Albuquerque, NM)
2007-12-11
An electrode array is disclosed which has applications for neural stimulation and sensing. The electrode array, in certain embodiments, can include a plurality of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. In other embodiments of the electrode array, the electrodes can be fixed to the substrate. The electrode array can be formed from a combination of bulk and surface micromachining, and can include electrode tips having an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis.
Microfabricated ion trap array
Blain, Matthew G.; Fleming, James G.
2006-12-26
A microfabricated ion trap array, comprising a plurality of ion traps having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale ion traps to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The reduced electrode voltage enables integration of the microfabricated ion trap array with on-chip circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of the microfabricated ion trap array can be realized in truly field portable, handheld microanalysis systems.
Botez, Dan; Scifres, Don R.
1994-08-01
This book provides a comprehensive overview of the fundamental principles and applications of semiconductor diode laser arrays. All of the major types of arrays are discussed in detail, including coherent, incoherent, edge- and surface-emitting, horizontal- and vertical-cavity, individually addressed, lattice- matched and strained-layer systems. The initial chapters cover such topics as lasers, amplifiers, external-cavity control, theoretical modeling, and operational dynamics. Spatially incoherent arrays are then described in detail, and the uses of vertical-cavity surface emitter and edge-emitting arrays in parallel optical-signal processing and multi-channel optical recording are discussed. Researchers and graduate students in solid state physics and electrical engineering studying the properties and applications of such arrays will find this book invaluable.
Benchmarks and models for 1-D radiation transport in stochastic participating media
Miller, D S
2000-08-21
Benchmark calculations for radiation transport coupled to a material temperature equation in a 1-D slab and 1-D spherical geometry binary random media are presented. The mixing statistics are taken to be homogeneous Markov statistics in the 1-D slab but only approximately Markov statistics in the 1-D sphere. The material chunk sizes are described by Poisson distribution functions. The material opacities are first taken to be constant and then allowed to vary as a strong function of material temperature. Benchmark values and variances for time evolution of the ensemble average of material temperature energy density and radiation transmission are computed via a Monte Carlo type method. These benchmarks are used as a basis for comparison with three other approximate methods of solution. One of these approximate methods is simple atomic mix. The second approximate model is an adaptation of what is commonly called the Levermore-Pomraning model and which is referred to here as the standard model. It is shown that recasting the temperature coupling as a type of effective scattering can be useful in formulating the third approximate model, an adaptation of a model due to Su and Pomraning which attempts to account for the effects of scattering in a stochastic context. This last adaptation shows consistent improvement over both the atomic mix and standard models when used in the 1-D slab geometry but shows limited improvement in the 1-D spherical geometry. Benchmark values are also computed for radiation transmission from the 1-D sphere without material heating present. This is to evaluate the performance of the standard model on this geometry--something which has never been done before. All of the various tests demonstrate the importance of stochastic structure on the solution. Also demonstrated are the range of usefulness and limitations of a simple atomic mix formulation.
A Mathematical Model of T1D Acceleration and Delay by Viral Infection.
Moore, James R; Adler, Fred
2016-03-01
Type 1 diabetes (T1D) is often triggered by a viral infection, but the T1D prevalence is rising among populations that have a lower exposure to viral infection. In an animal model of T1D, the NOD mouse, viral infection at different ages may either accelerate or delay disease depending on the age of infection and the type of virus. Viral infection may affect the progression of T1D via multiple mechanisms: triggering inflammation, bystander activation of self-reactive T-cells, inducing a competitive immune response, or inducing a regulatory immune response. In this paper, we create mathematical models of the interaction of viral infection with T1D progression, incorporating each of these four mechanisms. Our goal is to understand how each viral mechanism interacts with the age of infection. The model predicts that each viral mechanism has a unique pattern of interaction with disease progression. Viral inflammation always accelerates disease, but the effect decreases with age of infection. Bystander activation has little effect at younger ages and actually decreases incidence at later ages while accelerating disease in mice that do get the disease. A competitive immune response to infection can decrease incidence at young ages and increase it at older ages, with the effect decreasing over time. Finally, an induced Treg response decreases incidence at any age of infection, but the effect decreases with age. Some of these patterns resemble those seen experimentally. PMID:27030351
Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection.
Travis S Hughes
Full Text Available Fluorine (19F NMR has emerged as a useful tool for characterization of slow dynamics in 19F-labeled proteins. One-dimensional (1D 19F NMR spectra of proteins can be broad, irregular and complex, due to exchange of probe nuclei between distinct electrostatic environments; and therefore cannot be deconvoluted and analyzed in an objective way using currently available software. We have developed a Python-based deconvolution program, decon1d, which uses Bayesian information criteria (BIC to objectively determine which model (number of peaks would most likely produce the experimentally obtained data. The method also allows for fitting of intermediate exchange spectra, which is not supported by current software in the absence of a specific kinetic model. In current methods, determination of the deconvolution model best supported by the data is done manually through comparison of residual error values, which can be time consuming and requires model selection by the user. In contrast, the BIC method used by decond1d provides a quantitative method for model comparison that penalizes for model complexity helping to prevent over-fitting of the data and allows identification of the most parsimonious model. The decon1d program is freely available as a downloadable Python script at the project website (https://github.com/hughests/decon1d/.
Possible Dimensional Crossover to 1D of ^3He Fluid in Nanochannels Observed in Susceptibilities
Matsushita, Taku; Kurebayashi, Katsuya; Shibatsuji, Ryosuke; Hieda, Mitsunori; Wada, Nobuo
2016-05-01
Dimensional crossover to the one-dimensional (1D) state from higher dimensions has been studied for dilute ^3He fluid adsorbed in 2.4 nm ^4He-preplated nanochannels, by susceptibility measurements down to 70 mK using 4.29 MHz nuclear magnetic resonance. In nanochannels, since energy states of ^3He motion perpendicular to the channel axis are discrete, a genuine 1D ^3He fluid is expected when the Fermi energy is less than the first excitation Δ _{01} for azimuthal motion. The susceptibilities χ above 0.3 K show the Curie-law susceptibilities independent of the ^3He density, which are characteristic of nondegenerate fluid in higher dimensions. With decreasing the temperature, a significant reduction of χ T was observed from about 0.3 K for all ^3He densities. It is considered to be due to the dimensional crossover below Δ _{01}˜ 0.5 K to the 1D ^3He state in the semi-degenerate regime above the Fermi temperature. In the 1D state at lower temperatures, T-independent χ were observed for ^3He of 0.019 layers below 0.1 K. It suggests that the 1D ^3He fluid enters the quantum degenerate regime.
Introduction to adaptive arrays
Monzingo, Bob; Haupt, Randy
2011-01-01
This second edition is an extensive modernization of the bestselling introduction to the subject of adaptive array sensor systems. With the number of applications of adaptive array sensor systems growing each year, this look at the principles and fundamental techniques that are critical to these systems is more important than ever before. Introduction to Adaptive Arrays, 2nd Edition is organized as a tutorial, taking the reader by the hand and leading them through the maze of jargon that often surrounds this highly technical subject. It is easy to read and easy to follow as fundamental concept
Solution to 1-D consolidation of non-homogeneous soft clay
XIE Kang-he; WEN Jie-bang; XIA Jian-zhong
2005-01-01
In this work, semi-analytical methods were used to solve the problem of 1-D consolidation of non-homogeneous soft clay with spatially varying coefficients of permeability and compressibility. The semi-analytical solution was programmed and then verified by comparison with the obtained analytical solution of a special case. Based on the results of some computations and comparisons with the 1-D homogeneous consolidation (by Terzaghi) and the 1-D non-linear consolidation theory (by Davis et al.)of soft clay, some diagrams were prepared and the relevant consolidation behavior of non-homogeneous soils is discussed. It was shown that the result obtained differs greatly from Terzaghi's theory and that of the non-linear consolidation theory when the coefficients of permeability and compressibility vary greatly.
Transparent Conducting Electrodes based on 1D and 2D Ag Nanogratings for Organic Photovoltaics
Zeng, Beibei; Bartoli, Filbert J
2014-01-01
The optical and electrical properties of optically-thin one-dimensional (1D) Ag nanogratings and two-dimensional (2D) Ag nanogrids are studied, and their use as transparent electrodes in organic photovoltaics are explored. A large broadband and polarization-insensitive optical absorption enhancement in the organic light-harvesting layers is theoretically and numerically demonstrated using either single-layer 2D Ag nanogrids or two perpendicular 1D Ag nanogratings, and is attributed to the excitation of surface plasmon resonances and plasmonic cavity modes. Total photon absorption enhancements of 150% and 200% are achieved for the optimized single-layer 2D Ag nanogrids and double (top and bottom) perpendicular 1D Ag nanogratings, respectively.
Periodic Properties of 1D FE Discrete Models in High Frequency Dynamics
A. Żak
2016-01-01
Full Text Available Finite element discrete models of various engineering 1D structures may be considered as structures of certain periodic characteristics. The source of this periodicity comes from the discontinuity of stress/strain field between the elements. This behaviour remains unnoticeable, when low frequency dynamics of these structures is investigated. At high frequency regimes, however, its influence may be strong enough to dominate calculated structural responses distorting or even falsifying them completely. In this paper, certain computational aspects of structural periodicity of 1D FE discrete models are discussed by the authors. In this discussion, the authors focus their attention on an exemplary problem of 1D rod modelled according to the elementary theory.
PC-1D installation manual and user's guide
Basore, P.A.
1991-05-01
PC-1D is a software package for personal computers that uses finite-element analysis to solve the fully-coupled two-carrier semiconductor transport equations in one dimension. This program is particularly useful for analyzing the performance of optoelectronic devices such as solar cells, but can be applied to any bipolar device whose carrier flows are primarily one-dimensional. This User's Guide provides the information necessary to install PC-1D, define a problem for solution, solve the problem, and examine the results. Example problems are presented which illustrate these steps. The physical models and numerical methods utilized are presented in detail. This document supports version 3.1 of PC-1D, which incorporates faster numerical algorithms with better convergence properties than previous versions of the program. 51 refs., 17 figs., 5 tabs.
REAL-TIME FLOOD FORECASTING METHOD WITH 1-D UNSTEADY FLOW MODEL
MU Jin-bin; ZHANG Xiao-feng
2007-01-01
A real-time forecasting method coupled with the 1-D unsteady flow model with the recursive least-square method was developed. The 1-D unsteady flow model was modified by using the time-variant parameter and revising it dynamically through introducing a variable weighted forgetting factor, such that the output of the model could be adjusted for the real time forecasting of floods. The application of the new real time forecasting model in the reach from Yichang to Luoshan of the Yangtze River was demonstrated. Computational result shows that the forecasting accuracy of the new model is much higher than that of the original 1-D unsteady flow model. The method developed is effective for flood forecasting, and can be used for practical operation in the flood forecasting.
A comparison of 1D and 2D LSTM architectures for the recognition of handwritten Arabic
Yousefi, Mohammad Reza; Soheili, Mohammad Reza; Breuel, Thomas M.; Stricker, Didier
2015-01-01
In this paper, we present an Arabic handwriting recognition method based on recurrent neural network. We use the Long Short Term Memory (LSTM) architecture, that have proven successful in different printed and handwritten OCR tasks. Applications of LSTM for handwriting recognition employ the two-dimensional architecture to deal with the variations in both vertical and horizontal axis. However, we show that using a simple pre-processing step that normalizes the position and baseline of letters, we can make use of 1D LSTM, which is faster in learning and convergence, and yet achieve superior performance. In a series of experiments on IFN/ENIT database for Arabic handwriting recognition, we demonstrate that our proposed pipeline can outperform 2D LSTM networks. Furthermore, we provide comparisons with 1D LSTM networks trained with manually crafted features to show that the automatically learned features in a globally trained 1D LSTM network with our normalization step can even outperform such systems.
DEVELOPMENT OF COUPLED 1D-2D MATHEMATICAL MODELS FOR TIDAL RIVERS
XU Zu-xin; YIN Hai-long
2004-01-01
Some coupled 1D-2D hydrodynamic and water quality models depicting tidal water bodies with complex topography were presented. For the coupled models, finite element method was used to solve the governing equations so as to study tidal rivers with complex topography. Since the 1D and 2D models were coupled, the principle of model coupling was proposed to account appropriately for the factors of water level, flow and pollutant flux and the related dynamical behavior was simulated. Specifically the models were used to probe quantitative pollution contribution of receiving water from neighboring Jiangsu and Zhejiang Provinces to the pollution in the Huangpu River passing through Shanghai City. Numerical examples indicated that the developed coupled 1D-2D models are applicable in tidal river network region of Shanghai.
Spin Excitations and Phonon Anomaly in Quasi-1D Spiral Magneti CuBr2
Li, Yuan; Wang, Chong; Yu, Daiwei; Wang, Lichen; Wang, Fa; Iida, Kazuki; Kamazawa, Kazuya; Wakimoto, Shuichi
CuBr2 can be considered as a model quasi-one-dimensional (quasi-1D) spin-1/2 magnet, in which the frustrating ferromagnetic nearest-neighbor and antiferromagnetic next-nearest-neighbor exchange interactions give rise to a cycloidal magnetic order below TN = 73 K. The removal of inversion symmetry by the magnetic order also makes the material a type-II multiferroic system with a remarkably simple crystal structure. Using time-of-flight inelastic neutron scattering spectroscopy, we have determined the spin-wave as well as phonon spectra throughout the entire Brillouin zone. The spin-wave spectrum exhibits pronounced anisotropy and magnon damping, consistent with the material's quasi-1D nature and the non-colinear spin structure. The phonon spectrum exhibits dramatic discontinuities in the dispersion across the quasi-1D magnetic wave vector, indicative of strong magnetoelastic coupling and possibly of a spin-orbital texture that comes along with the spin correlations.
Modelling turbulent vertical mixing sensitivity using a 1-D version of NEMO
G. Reffray
2014-08-01
Full Text Available Through two numerical experiments, a 1-D vertical model called NEMO1D was used to investigate physical and numerical turbulent-mixing behaviour. The results show that all the turbulent closures tested (k + l from Blanke and Delecluse, 1993 and two equation models: Generic Lengh Scale closures from Umlauf and Burchard, 2003 are able to correctly reproduce the classical test of Kato and Phillips (1969 under favourable numerical conditions while some solutions may diverge depending on the degradation of the spatial and time discretization. The performances of turbulence models were then compared with data measured over a one-year period (mid-2010 to mid-2011 at the PAPA station, located in the North Pacific Ocean. The modelled temperature and salinity were in good agreement with the observations, with a maximum temperature error between −2 and 2 °C during the stratified period (June to October. However the results also depend on the numerical conditions. The vertical RMSE varied, for different turbulent closures, from 0.1 to 0.3 °C during the stratified period and from 0.03 to 0.15 °C during the homogeneous period. This 1-D configuration at the PAPA station (called PAPA1D is now available in NEMO as a reference configuration including the input files and atmospheric forcing set described in this paper. Thus, all the results described can be recovered by downloading and launching PAPA1D. The configuration is described on the NEMO site (http://www.nemo-ocean.eu/Using-NEMO/Configurations/C1D_PAPA. This package is a good starting point for further investigation of vertical processes.
Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.
Alfonzo-Méndez, Marco A; Castillo-Badillo, Jean A; Romero-Ávila, M Teresa; Rivera, Richard; Chun, Jerold; García-Sáinz, J Adolfo
2016-08-01
Human α1D-adrenoceptors are G protein-coupled receptors that mediate adrenaline/noradrenaline actions. There is a growing interest in identifying regulatory domains in these receptors and determining how they function. In this work, we show that the absence of the human α1D-adrenoceptor carboxyl tail results in altered ERK (extracellular signal-regulated kinase) and p38 phosphorylation states. Amino terminus-truncated and both amino and carboxyl termini-truncated α1D-adrenoceptors were transfected into Rat-1, HEK293, and B103 cells, and changes in the phosphorylation state of extracellular signal-regulated kinase was assessed using biochemical and biophysical approaches. The phosphorylation state of other protein kinases (p38, MEK1, and Raf-1) was also studied. Noradrenaline-induced ERK phosphorylation in Rat-1 fibroblasts expressing amino termini-truncated α1D-adrenoceptors. However, in cells expressing receptors with both amino and carboxyl termini truncations, noradrenaline-induced activation was abrogated. Interestingly, ERK phosphorylation that normally occurs through activation of endogenous G protein-coupled receptors, EGF receptors, and protein kinase C, was also decreased, suggesting that downstream steps in the mitogen-activated protein kinase pathway were affected. A similar effect was observed in B103 cells but not in HEK 293 cells. Phosphorylation of Raf-1 and MEK1 was also diminished in Rat-1 fibroblasts expressing amino- and carboxyl-truncated α1D-adrenoceptors. Our data indicate that expression of carboxyl terminus-truncated α1D-adrenoceptors alters ERK and p38 phosphorylation state. PMID:27146292
Column Testing and 1D Reactive Transport Modeling to Evaluate Uranium Plume Persistence Processes
Johnson, Raymond H. [Navarro Research and Engineering, Inc.; Morrison, Stan [Navarro Research and Engineering, Inc.; Morris, Sarah [Navarro Research and Engineering, Inc.; Tigar, Aaron [Navarro Research and Engineering, Inc.; Dam, William [U.S. Department of Energy, Office of Legacy Management; Dayvault, Jalena [U.S. Department of Energy, Office of Legacy Management
2016-04-26
Motivation for Study: Natural flushing of contaminants at various U.S. Department of Energy Office of Legacy Management sites is not proceeding as quickly as predicted (plume persistence) Objectives: Help determine natural flushing rates using column tests. Use 1D reactive transport modeling to better understand the major processes that are creating plume persistence Approach: Core samples from under a former mill tailings area Tailings have been removed. Column leaching using lab-prepared water similar to nearby Gunnison River water. 1D reactive transport modeling to evaluate processes
Refractive index sensor based on a 1D photonic crystal in a microfluidic channel
Rodrigues de Sousa Nunes, Pedro André; Mortensen, Asger; Kutter, Jörg Peter;
2010-01-01
A refractive index sensor has been fabricated in silicon oxynitride by standard UV lithography and dry etching processes. The refractive index sensor consists of a 1D photonic crystal (PhC) embedded in a microfluidic channel addressed by fiber-terminated planar waveguides. Experimental demonstrat......A refractive index sensor has been fabricated in silicon oxynitride by standard UV lithography and dry etching processes. The refractive index sensor consists of a 1D photonic crystal (PhC) embedded in a microfluidic channel addressed by fiber-terminated planar waveguides. Experimental...
Characterization of 5-HT1D receptor binding sites in post-mortem human brain cortex.
Martial, J; de Montigny, C; Cecyre, D; Quirion, R
1991-01-01
The present study provides further evidence for the presence of serotonin1D (5-HT1D) receptors in post-mortem human brain. Receptor binding parameters in temporal cortex homogenates were assessed using [3H]5-HT in the presence of 100 nM 8-OH-DPAT, 1 microM propranolol and 1 microM mesulergine to prevent labelling of the 5-HT1A, 5-HT1B and 5-HT1C sites, respectively. Under these conditions, [3H]5-HT apparently bound to a class of high affinity (Kd = 5.0 +/- 1.0 nM) low capacity (Bmax = 96 +/- ...
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Hasbi Ahmed
2011-06-01
Full Text Available Abstract Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.
AM1/d parameters for Magnesium in Metalloenzymes. Journal of Chemical Theory and Computation
Imhof, Petra [University of Heidelberg; Noe, F [University of Heidelberg; Fischer, S. [University of Heidelberg; Smith, Jeremy C [ORNL
2006-06-01
AM1/d parameters are derived for magnesium, optimized for modeling reactions in metalloenzymes. The parameters are optimized with a Monte Carlo procedure so as to reproduce the geometries and energies of a training set calculated with density functional theory. The training set consists of compounds with magnesium coordinated to the oxygen atom of typical biological ligands. Optimization of AM1 parameters without extension to d functions leaves serious errors. The new AM1/d parameters provide a clear improvement in accuracy compared to the standard semiempirical methods AM1 and MNDO/d and will be particularly useful for modeling reactions in large biological systems at low computational cost.
Flexible retinal electrode array
Okandan, Murat (Albuquerque, NM); Wessendorf, Kurt O. (Albuquerque, NM); Christenson, Todd R. (Albuquerque, NM)
2006-10-24
An electrode array which has applications for neural stimulation and sensing. The electrode array can include a large number of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. The electrode array can be formed from a combination of bulk and surface micromachining, with electrode tips that can include an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis where the electrodes can be tailored to provide a uniform gentle contact pressure with optional sensing of this contact pressure at one or more of the electrodes.
Expandable LED array interconnect
Yuan, Thomas Cheng-Hsin; Keller, Bernd
2011-03-01
A light emitting device that can function as an array element in an expandable array of such devices. The light emitting device comprises a substrate that has a top surface and a plurality of edges. Input and output terminals are mounted to the top surface of the substrate. Both terminals comprise a plurality of contact pads disposed proximate to the edges of the substrate, allowing for easy access to both terminals from multiple edges of the substrate. A lighting element is mounted to the top surface of the substrate. The lighting element is connected between the input and output terminals. The contact pads provide multiple access points to the terminals which allow for greater flexibility in design when the devices are used as array elements in an expandable array.
Protein Functionalized Nanodiamond Arrays
Liu YL
2010-01-01
Full Text Available Abstract Various nanoscale elements are currently being explored for bio-applications, such as in bio-images, bio-detection, and bio-sensors. Among them, nanodiamonds possess remarkable features such as low bio-cytotoxicity, good optical property in fluorescent and Raman spectra, and good photostability for bio-applications. In this work, we devise techniques to position functionalized nanodiamonds on self-assembled monolayer (SAMs arrays adsorbed on silicon and ITO substrates surface using electron beam lithography techniques. The nanodiamond arrays were functionalized with lysozyme to target a certain biomolecule or protein specifically. The optical properties of the nanodiamond-protein complex arrays were characterized by a high throughput confocal microscope. The synthesized nanodiamond-lysozyme complex arrays were found to still retain their functionality in interacting with E. coli.
Permutations of cubical arrays
The structure constants of an algebra determine a cube called the cubical array associated with the algebra. The permuted indices of the cubical array associated with a finite semifield generate new division algebras. We do not not require that the algebra be finite and ask 'Is it possible to choose a basis for the algebra such any permutation of the indices of the structure constants leaves the algebra unchanged?' What are the associated algebras? Author shows that the property 'weakly quadratic' is invariant under all permutations of the indices of the corresponding cubical array and presents two algebras for which the cubical array is invariant under all permutations of the indices.
Highlights: • The Ni nanowires with different diameters have been fabricated in the AAO templates. • The high-temperature magnetic properties of 1D nanowire arrays are reported. • The templates can suppress growth of nanowires during high-temperature measurements. • The Curie temperature follows a finite-size scaling theory with λ = 0.926 and ξ0 = 17.35 Å. - Abstract: Ordered Ni nanowire arrays were successfully fabricated by electrochemical deposition method based on the anodized aluminum oxide (AAO) templates. It was found that the diameter of nanowire can be well controlled by the pore size of AAO template. The nanowire arrays with 50 nm in diameter were characterized by X-ray diffraction, electron microscopy, and physical properties measurement system. The results indicate that the polycrystalline Ni nanowire arrays exhibit obvious magnetic anisotropy, and the easy magnetization direction is oriented along the nanowire axial direction. By measuring the temperature dependence of magnetization, the Curie temperatures of nanowires with different sizes were obtained. The Curie temperature of one-dimensionality (1D) nanowire arrays is found to decrease with decreasing diameter and follow a finite-size scaling theory with λ = 0.926 and ξ0 = 17.35 Å. The fitting exponent of 1D nanowire arrays is close to the nanoparticles (zero-dimensionality, 0D) result and two-dimensionality (2D) nano-films result
Henzinger, Thomas A.; Hottelier, Thibaud; Kovács, Laura; Rybalchenko, Andrey
2010-01-01
This paper presents Aligators, a tool for the generation of universally quantified array invariants. Aligators leverages recurrence solving and algebraic techniques to carry out inductive reasoning over array content. The Aligatorsâ€™ loop extraction module allows treatment of multi-path loops by exploiting their commutativity and serializability properties. Our experience in applying Aligators on a collection of loops from open source software projects indicates the applicability of recurren...
Capdevila Cascante, Santiago; Jofre Roca, Lluís; Romeu Robert, Jordi; Bolomey, J.Ch
2010-01-01
In this paper the use of RFID tags for the measurement of physical parameters in a distributed set of points is presented. Experimental results for two different scenarios are presented; the first uses a 2D RFID array to measure the field distribution of a radiating aperture, while the second detects the change in the close environment of an array of RFID tags to determine the water level of a container.
Microphone arrays fundamentals
Embrechts, Jean-Jacques
2011-01-01
Microphone arrays are essentially directional sensors. They are therefore mainly used for locating, identifying, isolating, measuring and recording individual sound sources. The main principles governing the directivity of microphone arrays are reviewed: phase differences between signals create constructive and destructive interferences, depending on the direction of the sound source. Moreover, signal processing is applied to provide “beamforming”, i.e. beam shaping and steering. Contrary to ...
D1D5 systems and AdS/CFT correspondences with 16 supercharges
Gava, E; Morales, J F; Narain, Kumar S; Gava, Edi; Hammou, Amine B.; Morales, Jose F.; Narain, Kumar S.
2002-01-01
We study the spectra of BPS excitations of D1D5 bound states in a class of free orbifolds/orientifolds of type IIB theory and its dual descriptions in terms of chiral primaries of the corresponding $AdS_3$ supergravities.
Fresnel Lenses fabricated by femtosecond laser micromachining on Polymer 1D Photonic Crystal
Guduru Surya S.K.
2013-11-01
Full Text Available We report the fabrication of micro Fresnel lenses by femtosecond laser surface ablation on polymer 1D photonic crystals. This device is designed to focus the transmitted wavelength of the photonic crystal and filter the wavelengths corresponding to the photonic band gap region. Integration of such devices in a wavelength selective light harvesting and filtering microchip can be achieved.